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Research, Validations and Clinical Studies about Virtual Reality. Ivan Alsina-Jurnetn, José Gutiérrez Maldonado (2010). Influence of personality and individual abilities on the sense of presence experienced in anxiety triggering virtual environments. Journal of Human-Computer Studies, 68, 788-801. B. O. Rothbaum, L. Hodges, S. Smith, J. H. Lee, L. Price (2000). A Controlled Study of Virtual Reality Exposure Therapy for the Fear of Flying. Journal of Consulting and Clinical Psychology, 68 (6), 1020-1026 Juana Bretón-López, Miquel Tortella-Feliu, Antonio Riera del Amo, Rosa Baños, Jordi Llabrés, Joan M. Gelabert, and Cristina Botella (2015). Patients preferences regarding three computer-based exposure treatments for fear of flying. Behavioral Psychology, 23 (2), 265-285. S. Bouchard, P. Renaud, G. Robillard, J. St-Jaques (2002). Applications of Virtual Reality in Clinical Psychology: Illustrations with the treatment of anxiety disorders. Haptic Virtual Environments and Their Applications, pp. 7-11. M. Slater, D. P. Pertaub and A. Steed (1999). Public speaking in virtual reality: facing an audience of avatars, IEEE Computer Graphics and Applications, 19 (2), pp. 6-9. Marilyn P. Safir, Helene S. Wallach, Margalit Bar-Zvi (2012). Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial, Behavior Modification, 33 (3), 314-38. Vlasios Brakoulias (2013). Virtual reality can help to develop a new reality, The Australian and New Zealand Journal of Psychiatry 47 (2), 186-7. W. P. Castro, M. J. R. Sanchez, C. T. P. González, J. M. Bethencourt, J. A. de la Fuente Portero, R. G. Marco (2013). Cognitive-behavioral treatment and antidepressants combined with virtual reality exposure for patients with chronic agoraphobia, International Journal of Clinical and Health Psychology, 14 (1), 9-17. Isabel L. Kampmann, Nexhmedin Morina, Paul G. M. Emmelkamp, Mark A. Neerincx, Willem-Paul Brinkman (2014). Controlling Social Stress in Virtual Reality Environments, PLoS.org, 9(3), e92804. José Gutiérrez-Maldonado, Ivan Alsina-Jurnet, María Virginia Rangel-Gómez, Angel Aguilar-Alonso,Adolfo José Jarne-Esparcia, Antonio Andrés-Pueyo, Antoni Talarn-Caparrós (2008). Virtual Intelligent Agents to Train Abilities of Diagnosis in Psychology and Psychiatry, New Directions in Intelligent Interactive Multimedia, 142, 497-505. R. M. Baños, V. Guillen, S. Quero, A. García-Palacios, M. Alcaniz, C. Botella (2011). A virtual reality system for the treatment of stress-related disorders: A preliminary analysis of efficacy compared to a standard cognitive behavioral program, International Journal of Human-Computer Studies, 69 (9), 602-613. Raquel Gonçalves, Ana Lúcia Pedrozo, Evandro Silva Freire Coutinho, Ivan Figueira, and Paula Ventura (2012). Efficacy of Virtual Reality Exposure Therapy in the Treatment of PTSD: A Systematic Review, PLoS.org, 7(12), e48469.
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Research, Validations and Clinical Studies about Virtual Reality.

Ivan Alsina-Jurnetn, José Gutiérrez Maldonado (2010). Influence of personality and individual abilities on the sense of presence experienced in anxiety triggering virtual environments.Journal of Human-Computer Studies, 68, 788-801.

B. O. Rothbaum, L. Hodges, S. Smith, J. H. Lee, L. Price (2000).A Controlled Study of Virtual Reality Exposure Therapy for the Fear of Flying. Journal of Consulting and Clinical Psychology, 68 (6), 1020-1026

Juana Bretón-López, Miquel Tortella-Feliu, Antonio Riera del Amo, Rosa Baños, Jordi Llabrés, Joan M. Gelabert, and Cristina Botella (2015). Patients preferences regarding three computer-based exposure treatments for fear of flying. Behavioral Psychology, 23 (2), 265-285.

S. Bouchard, P. Renaud, G. Robillard, J. St-Jaques (2002).Applications of Virtual Reality in Clinical Psychology: Illustrations with the treatment of anxiety disorders.Haptic Virtual Environments and Their Applications, pp. 7-11.

M. Slater, D. P. Pertaub and A. Steed (1999).Public speaking in virtual reality: facing an audience of avatars,IEEE Computer Graphics and Applications, 19 (2), pp. 6-9.

Marilyn P. Safir, Helene S. Wallach, Margalit Bar-Zvi (2012).Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial, Behavior Modification, 33 (3), 314-38.

Vlasios Brakoulias (2013). Virtual reality can help to develop a new reality, The Australian and New Zealand Journal of Psychiatry 47 (2), 186-7.

W. P. Castro, M. J. R. Sanchez, C. T. P. González, J. M. Bethencourt, J. A. de la Fuente Portero, R. G. Marco (2013). Cognitive-behavioral treatment and antidepressants combined with virtual reality exposure for patients with chronic agoraphobia, International Journal of Clinical and Health Psychology, 14 (1), 9-17.

Isabel L. Kampmann, Nexhmedin Morina, Paul G. M. Emmelkamp, Mark A. Neerincx, Willem-Paul Brinkman (2014).Controlling Social Stress in Virtual Reality Environments, PLoS.org, 9(3), e92804.

José Gutiérrez-Maldonado, Ivan Alsina-Jurnet, María Virginia Rangel-Gómez, Angel Aguilar-Alonso,Adolfo José Jarne-Esparcia, Antonio Andrés-Pueyo, Antoni Talarn-Caparrós (2008). Virtual Intelligent Agents to Train Abilities of Diagnosis in Psychology and Psychiatry, New Directions in Intelligent Interactive Multimedia, 142, 497-505.

R. M. Baños, V. Guillen, S. Quero, A. García-Palacios, M. Alcaniz, C. Botella (2011).A virtual reality system for the treatment of stress-related disorders: A preliminary analysis of efficacy compared to astandard cognitive behavioral program,International Journal of Human-Computer Studies, 69 (9), 602-613.

Raquel Gonçalves, Ana Lúcia Pedrozo, Evandro Silva Freire Coutinho, Ivan Figueira, and Paula Ventura (2012). Efficacy of Virtual Reality Exposure Therapy in the Treatment of PTSD: A Systematic Review, PLoS.org, 7(12), e48469.

Research, Validations and Clinical Studies about Virtual Reality.

Ivan Alsina-Jurnetn, José Gutiérrez Maldonado (2010).Influence of personality and individual abilities on the sense of presence experienced in anxiety triggering virtual environments.Journal of Human-Computer Studies, 68, 788-801.

B. O. Rothbaum, L. Hodges, S. Smith, J. H. Lee, L. Price (2000).A Controlled Study of Virtual Reality Exposure Therapy for the Fear of Flying. Journal of Consulting and Clinical Psychology, 68 (6), 1020-1026

Juana Bretón-López, Miquel Tortella-Feliu, Antonio Riera del Amo, Rosa Baños, Jordi Llabrés, Joan M. Gelabert, and Cristina Botella (2015). Patients preferences regarding three computer-based exposure treatments for fear of flying. Behavioral Psychology, 23 (2), 265-285.

S. Bouchard, P. Renaud, G. Robillard, J. St-Jaques (2002). Applications of Virtual Reality in Clinical Psychology: Illustrations with the treatment of anxiety disorders. Haptic Virtual Environments and Their Applications, pp. 7-11.

M. Slater, D. P. Pertaub and A. Steed (1999). Public speaking in virtual reality: facing an audience of avatars, IEEE Computer Graphics and Applications, 19 (2), pp. 6-9.

Marilyn P. Safir, Helene S. Wallach, Margalit Bar-Zvi (2012).Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial, Behavior Modification, 33 (3), 314-38.

Vlasios Brakoulias (2013). Virtual reality can help to develop a new reality, The Australian and New Zealand Journal of Psychiatry 47 (2), 186-7.

W. P. Castro, M. J. R. Sanchez, C. T. P. González, J. M. Bethencourt, J. A. de la Fuente Portero, R. G. Marco (2013). Cognitive-behavioral treatment and antidepressants combined with virtual reality exposure for patients with chronic agoraphobia, International Journal of Clinical and Health Psychology, 14 (1), 9-17.

Isabel L. Kampmann, Nexhmedin Morina, Paul G. M. Emmelkamp, Mark A. Neerincx, Willem-Paul Brinkman (2014).Controlling Social Stress in Virtual Reality Environments, PLoS.org, 9(3), e92804.

José Gutiérrez-Maldonado, Ivan Alsina-Jurnet, María Virginia Rangel-Gómez, Angel Aguilar-Alonso,Adolfo José Jarne-Esparcia, Antonio Andrés-Pueyo, Antoni Talarn-Caparrós (2008). Virtual Intelligent Agents to Train Abilities of Diagnosis in Psychology and Psychiatry, New Directions in Intelligent Interactive Multimedia, 142, 497-505.

R. M. Baños, V. Guillen, S. Quero, A. García-Palacios, M. Alcaniz, C. Botella (2011). A virtual reality system for the treatment of stress-related disorders: A preliminary analysis of efficacy compared to a standard cognitive behavioral program, International Journal of Human-Computer Studies, 69 (9), 602-613.

Raquel Gonçalves, Ana Lúcia Pedrozo, Evandro Silva Freire Coutinho, Ivan Figueira, and Paula Ventura (2012). Efficacy of Virtual Reality Exposure Therapy in the Treatment of PTSD: A Systematic Review, PLoS.org, 7(12), e48469.

G. M. Reger, G. A. Gahm (2008).Virtual reality exposure therapy for active duty soldiers,Journal of Clinical Psychology, 64(8),940-6.

D. P. Wood, J. Murphy, K. Center, R. McLay, D. Reeves, R. Shilling, B. K. Wiederhold (2007).Combat-related post-traumatic stress disorder: a case report using virtual reality exposure therapy withphysiological monitoring,Cyberpsychology and Behavior, 10(2), 309-15.

Giuseppe Riva (2003). Virtual environments in clinical psychology, Psychotherapy: Theory/Research/Practice/Training, 40 (1/2), 000-000.

Daniel Freeman, Jonathan Bradley, Angus Antley, Emilie Bourke, Natalie DeWeever, Nicole Evans, Emma Černis, Bryony Sheaves,Felicity Waite, Graham Dunn, Mel Slater, David M. Clark (2016).Virtual reality in the treatment of persecutory delusions: randomised controlled experimental study testing how to reduce delusional conviction, The British Journal of Psychiatry, 209 (1), 62-67.

Anderson, P. L., Price, M., Edwards, S. M., Obasaju, M. A., Schmertz, S. K., Zimand, E., & Calamaras, M. R. (2013). Virtual reality exposure therapy for social anxiety disorder: A randomized controlled trial,Journal of Consulting and Clinical Psychology, 81(5), 75

Beck, J. G., Palyo, S. A., Winer, E. H., Schwagler, B. E., & Ang, E. J. (2007).Virtual reality exposure therapy for PTSD symptoms after a road accident: An uncontrolled case series.Behavior Therapy, 38(1), 39-48.

Botella, C., García-Palacios, A., Guillen, V., Baños, R. M., Quero, S., & Alcaniz, M. (2010).An adaptive display for the treatment of diverse trauma PTSD victims. CyberPsychology, Behavior & Social Networking, 13(1), 67-71.

Cárdenas, G., & De La Rosa, A. (2012). Using virtual reality for PTSD treatment in criminal violence victims. Journal of CyberTherapy and Rehabilitation, 5(1), 65-67.

Cesa, G. L., Manzoni, G. M., Bacchetta, M., Castelnuovo, G., Conti, S., Gaggioli, A., . . . Riva, G. (2013).Virtual reality for enhancing the cognitive behavioral treatment of obesity with binge eating disorder: Randomized controlled study with one-year follow-up. Journal of Medical Internet Research, 15(6), e113.

Difede, J., Cukor, J., Jayasinghe, N., Patt, I., Jedel, S., Spielman, Hoffman, H. G. (2007). Virtual reality exposure therapy for the treatment of posttraumatic stress disorder following september 11, 2001. The Journal of Clinical Psychiatry, 68(11), 1639-1647.

Ferrer-García, M., & Gutiérrez-Maldonado, J. (2012; 2011). The use of virtual reality in the study, assessment, and treatment of body image in eating disorders and nonclinical samples: A review of the literature.Body Image, 9(1),

Ferrer-Garcia, M., Gutiérrez-Maldonado, J., & Riva, G. (2013). Virtual reality based treatments in eating disorders and obesity: A review.Journal of Contemporary Psychotherapy, 43(4), 207-221.

Gerardi, M., Cukor, J., Difede, J., Rizzo, A., & Rothbaum, B. (2010).Virtual reality exposure therapy for post-traumatic stress disorder and other anxiety disorders. Current Psychiatry Reports, 12(4), 298-305.

Gerardi, M., Rothbaum, B. O., Ressler, K., Heekin, M., & Rizzo, A. (2008). Virtual reality exposure therapy using a virtual iraq: Case report.Journal of Traumatic Stress, 21(2), 209-213.

Research, Validations and Clinical Studies about Virtual Reality.

Ivan Alsina-Jurnetn, José Gutiérrez Maldonado (2010).Influence of personality and individual abilities on the sense of presence experienced in anxiety triggering virtual environments.Journal of Human-Computer Studies, 68, 788-801.

B. O. Rothbaum, L. Hodges, S. Smith, J. H. Lee, L. Price (2000).A Controlled Study of Virtual Reality Exposure Therapy for the Fear of Flying. Journal of Consulting and Clinical Psychology, 68 (6), 1020-1026

Juana Bretón-López, Miquel Tortella-Feliu, Antonio Riera del Amo, Rosa Baños, Jordi Llabrés, Joan M. Gelabert, and Cristina Botella (2015). Patients preferences regarding three computer-based exposure treatments for fear of flying. Behavioral Psychology, 23 (2), 265-285.

S. Bouchard, P. Renaud, G. Robillard, J. St-Jaques (2002). Applications of Virtual Reality in Clinical Psychology: Illustrations with the treatment of anxiety disorders. Haptic Virtual Environments and Their Applications, pp. 7-11.

M. Slater, D. P. Pertaub and A. Steed (1999). Public speaking in virtual reality: facing an audience of avatars, IEEE Computer Graphics and Applications, 19 (2), pp. 6-9.

Marilyn P. Safir, Helene S. Wallach, Margalit Bar-Zvi (2012).Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial, Behavior Modification, 33 (3), 314-38.

Vlasios Brakoulias (2013). Virtual reality can help to develop a new reality, The Australian and New Zealand Journal of Psychiatry 47 (2), 186-7.

W. P. Castro, M. J. R. Sanchez, C. T. P. González, J. M. Bethencourt, J. A. de la Fuente Portero, R. G. Marco (2013). Cognitive-behavioral treatment and antidepressants combined with virtual reality exposure for patients with chronic agoraphobia, International Journal of Clinical and Health Psychology, 14 (1), 9-17.

Isabel L. Kampmann, Nexhmedin Morina, Paul G. M. Emmelkamp, Mark A. Neerincx, Willem-Paul Brinkman (2014).Controlling Social Stress in Virtual Reality Environments, PLoS.org, 9(3), e92804.

José Gutiérrez-Maldonado, Ivan Alsina-Jurnet, María Virginia Rangel-Gómez, Angel Aguilar-Alonso,Adolfo José Jarne-Esparcia, Antonio Andrés-Pueyo, Antoni Talarn-Caparrós (2008). Virtual Intelligent Agents to Train Abilities of Diagnosis in Psychology and Psychiatry, New Directions in Intelligent Interactive Multimedia, 142, 497-505.

R. M. Baños, V. Guillen, S. Quero, A. García-Palacios, M. Alcaniz, C. Botella (2011). A virtual reality system for the treatment of stress-related disorders: A preliminary analysis of efficacy compared to a standard cognitive behavioral program, International Journal of Human-Computer Studies, 69 (9), 602-613.

Raquel Gonçalves, Ana Lúcia Pedrozo, Evandro Silva Freire Coutinho, Ivan Figueira, and Paula Ventura (2012). Efficacy of Virtual Reality Exposure Therapy in the Treatment of PTSD: A Systematic Review, PLoS.org, 7(12), e48469.

Gonçalves, R., Pedrozo, A. L., Freire Coutinho, E. S., Figueira, I., & Ventura, P. (2012). Efficacy of virtual reality exposure therapy in the treatment of PTSD: A systematic review. Plos One, 7(12), 1-7.

McLay, R. N., Graap, K., Spira, J., Perlman, K., Johnston, S., Rothbaum, B. O., . . . Rizzo, A. (2012). Development and testing of virtual reality exposure therapy for post-traumatic stress disorder in active duty service members who served in iraq and afghanistan. Military Medicine, 177(6), 635-642.

McLay, R. N., McBrien, C., Wiederhold, M. D., & Wiederhold, B. K. (2010).Exposure therapy with and without virtual reality to treat PTSD while in the combat theater: A parallel case series. CyberPsychology, Behavior & Social Networking, 13(1), 37-42.

McLay, R. N., Wood, D. P., Webb-Murphy, J. A., Spira, J. L., Wiederhold, M. D., Pyne, J. M., & Wiederhold, B. K. (2011).A randomized, controlled trial of virtual reality-graded exposure therapy for post-traumatic stress disorder in activeduty service members with combat-related post-traumatic stress disorder.Cyberpsychology, Behavior, and Social Networking, 14(4), 223-229.

Parsons, T. D., & Rizzo, A. A. (2008). Affective outcomes of virtual reality exposure therapy for anxiety and specific phobias: A meta-analysis.Journal of Behavior Therapy and Experimental Psychiatry, 39(3), 250-261.

Perpiñá, C., Roncero, M., Fernández-Aranda, F., Jiménez-Murcia, S., Forcano, L., & Sánchez, I. (2013).Clinical validation of a virtual environment for normalizing eating patterns in eating disorders. Comprehensive Psychiatry, 54(6), 680.

Powers, M. B., & Emmelkamp, P. M. G. (2008). Virtual reality exposure therapy for anxiety disorders: A meta-analysis. Journal of Anxiety Disorders, 22(3), 561-569.

Ready, D. J., Gerardi, R. J., Backscheider, A. G., Mascaro, N., & Rothbaum, B. O. (2010). Comparing virtual reality exposure therapy to present-centered therapy with 11 U.S. vietnam veterans with PTSD.CyberPsychology, Behavior & Social Networking, 13(1), 49-54.

Reger, G. M., Holloway, K. M., Candy, C., Rothbaum, B. O., Difede, J., Rizzo, A. A., & Gahm, G. A. (2011). Effectiveness of virtual reality exposure therapy for active duty soldiers in a military mental health clinic. Journal of Traumatic Stress, 24(1), 93-96.

Rizzo, A., Hartholt, A., Grimani, M., Leeds, A., & Liewer, M. (2014). Virtual reality exposure therapy for combat-related posttraumatic stress disorder. Computer, 47(7), 31-37.

Rothbaum, B. O., Rizzo, & Difede, J. (2010). Virtual reality exposure therapy for combat-related posttraumatic stress disorder. Annals of the New York Academy of Sciences, 1208(1), 126-132.

Institution/s Disorder Experimental group Control group N Aim of the study Treatment Description

Claustrophobia Exposure with VR No treatment 30Anxiety reduction equal or greater than the control group which is not using VR.

Exposure to VR prerecorded sessions. Delivered by a nurse while in the waiting room.

ADHD Mindfulness treatment with Virtual Reality

Treatment as Usual 50Improvements in attention and hyperactivity equal or greater than the Treatment as Usual group.

Mindfulness pre-recorded sessions. Delivered at the clinic by the psychologist.

Social Anxiety VR exposure - 30Anxiety reduction after repeated VRET

Real time sessions controlled by the psychologist at the consultation.

Childhood Anxiety

Training in Relaxation techniques With VR

Training in Relaxation Techniques Without VR

12

Anxiety reduction equal or greater than the control group which is not using VR.

Real time sessions controlled by the psychologist at the consultation.

Psious + pharmacological treatment

AgoraphobiaRelaxation in a group setting VR

Relaxation in a group setting without VR

12 Reducing anxiety (equal or greater than the control group).

Real time relaxation sessions delivered at the clinic by the psychologist to up to 12 patients at the same time.

For confidentiality reasons, further information about this study cannot be disclosed.

Ongoing Studies

Servicio Murciano Salud

• Group sessions• 4 centers • 20 patients• ‘Randomized selection’• Control using traditional therapies

Clinical validation –Not published yet

J is an 8-year-old boy that according to his parents and school tutors, was experiencing serious problems at the moments where he had to pay attention and stay focused, and also had difficulties when he had to concentrate on any given task. Those closest to him, described him as a restless and nervous child who did not like doing a thing for more than a short amount of time. He had been referred to several professionals before without significant progress, mainly because he lost interest in the treatment easily and was not thoroughly involved.

We decided that a case like J’s could benefit from a session with the virtual environment the meadow, originally designed for Mindfulness. When we first introduced the environment to him, he showed an enormous fascination, capturing his interest almost immediately. From there, we got his full involvement during the whole process, which significantly eased the process and helped him to pay attention to the stimulus.

Despite the notorious hyperactivity presented before, when he had the glasses on, he could calm down enough to follow the instructions of the exercises, which would also favor his listening skills and concentration throughout the task.

At the end of the session and after taking the glasses off, J remained in a state of calm without going back to the activation levels that presented at the beginning of the session. He also told us about how glad he was with this experience and that he would be more than happy to do it again in the future.

Clinical Case 2016

Date: 06/21/2016Patient: J. E.Reason for Consultation:

Environment: The Meadow

www.psious.com

ADHD, trouble concentrating and staying focused.

When R arrived at our office a few months ago, he told us that since he was young he has experienced an intense fear of the sea, and just the idea of getting into the beach was terrifying. This fear was due to a traumatic incident back when he was 11, where he was attacked by a mako shark while scuba diving with his grandfather. What at the time was a hobby and passion, quickly became a trauma that would completely prevent him from getting into the water, and even prevent him from enjoying other aquatic activities, even if they presented in a different context.

Among his many fears, he stressed that the idea that any animal (not necessarily a shark) could suddenly attack him while he was in the water constantly invaded his thoughts.

We decided to expose R to the under the sea relaxation environment. Since it was the first time in many years he looked in an underwater environment, he showed extremely high levels of anxiety (nine on a 1-10 scale) especially at the beginning of the session. We applied diaphragmatic breathing exercisesmany times during the session until the anxiety levels gradually decreased to three.

After the session, R informed us that he felt much better and was glad to have remained calm in the difficult moments at the beginning of the session, especially at the time that the shark shows up. He said he could not have done it otherwise since exposure imagination had not worked and the real exposure was out of the question for him.

Clinical Case 2016

Date: 06/29/2016Patient: R. E.Reason for Fear of the Sea. AvoidanceConsultation: of situations that involve

getting into the water.

Environment: Under the Sea Relaxation Environment

www.psious.com


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