Respiratory SystemRespiratory System

   Exchange of oxygen and carbon

dioxide between the blood and the muscle tissues

Exchange of oxygen and carbon dioxide between the lungs and blood

The breathing of air into and out of the lungs

Mechanics of Mechanics of BreathingBreathing

Inspiration: External intercostals muscles contract during

inspiration Diaphragm contracts (downwards and flattens) This pulls the rib cage upwards and outwards These actions cause the thoracic cavity size to increase This decreases the pressure inside the thoracic cavity Gases move from areas of high pressure to low

pressure areas Therefore oxygen moves from the atmosphere (higher

pressure) into the lungs (now low in pressure) During exercise, a more forceful inspiration is required

so extra muscles are involved in this process – sternocleidomastoid and pectoralis minor

Expiration Usually a passive process As the intercostals muscles relax the rib cage

moves downwards The diaphragm relaxes and returns to its dome

shape This decreases the size of the thoracic cavity This causes the pressure to increase in the thoracic

cavity (smaller volume) Therefore gases move out of the lungs (high

pressure) into the atmosphere (lower pressure) During exercise breathing rate is increased,

expiration is aided by the internal intercostal muscles and the abdominal muscles,

This pulls the rib cage down more quickly and with greater force

Gaseous ExchangeGaseous Exchange

Key Terms: Gaseous Exchange – the process of

exchanging O2 and CO2 Partial Pressure - the pressure a gas exerts

in a mixture of gases Diffusion - The movement of gases from areas

of higher partial pressure to lower partial pressure

Diffusion Gradient - The difference between high and low pressure of gases. The bigger the gradient the greater the diffusion.

External RespirationExternal Respiration

Involves the movement of oxygen and carbon dioxide between the alveoli of the lungs and capillaries surrounding the alveoli.

The aim of external respiration is to oxygenate the blood returning from the tissues

As blood circulates through the capillaries surrounding the alveoli oxygen is picked up and carbon dioxide is dropped off to be expired

Internal RespirationInternal Respiration

Involves the movement of O2 and CO2 between the capillaries surrounding the muscles and the muscle tissues

The aim of internal respiration is to oxygenate the muscles and collect CO2 to return it to the alveoli

These processes can only happen if a diffusion gradient is present.

External and Internal External and Internal Respiration Showing Respiration Showing

Changes in O2 and CO2Changes in O2 and CO2

Oxygen-Haemoglobin Oxygen-Haemoglobin Dissociation CurveDissociation Curve

Shows us how much haemoglobin is saturated with oxygenSaturated – when haemoglobin is loaded with oxygenDissociation – where oxygen is unloaded from the haemoglobinThe higher the partial pressure of oxygen, the higher percentage of oxygen saturation to haemoglobin

Oxygen associates with haemoglobin at the lungs and dissociates at the muscles (because PP of O2 is high at lungs and low at muscles)

During exercise a greater amount of dissociation of O2 at the muscles is required, therefore less saturation at the muscles has to occur

Four factors happen in our bodies during exercise to allow this to occur

Factors Affecting the Factors Affecting the saturation of oxygen to saturation of oxygen to

haemoglobinhaemoglobin Increase in temperature – in the blood and muscles

during exercise Decrease in PP of O2 – within the muscles during

exercise, therefore creating a greater diffusion gradient

Increase in PP of CO2 – therefore causing a greater CO2 diffusion gradient

Increase in acidity – lowering the pH of the blood through production of lactic acid (more hydrogen ions produced). This is known as the BOHR SHIFT

All four of these factors (which occur during exercise) increases the dissociation of oxygen from haemoglobin, which increases the supply of oxygen to the working muscles and therefore delays fatigue..

Exam Style Question: What happens to the oxygen-Haemoglobin

Dissociation Curve during exercise? (6 marks)

It shifts to the right Because during exercise there is an

increase in blood/muscle temperature Decrease in PP of O2 in the muscles Increase in PP of CO2 in muscles Increase in acidity (more lactic acid) Known as Bohr Effect/Shift

MyoglobinMyoglobin

Has a higher affinity for O2 than haemoglobin

Therefore acts as a store of O2 Even at very low partial pressures of

02 (the muscles when exercising) it remains saturated

This means that myoglobin still has O2 available to supply the working muscles.

Respiratory Adaptations to Respiratory Adaptations to TrainingTrainingReduction in breathing rate during

sub-maximal exercise,System is more efficient therefore less breaths required,No changes in lung volumes except. . . .Vital capacity – amount of air that air that can be forcibly expired after can be forcibly expired after maximal inspirationmaximal inspiration – increases – increases slightly, largely due to stronger slightly, largely due to stronger respiratory musclesrespiratory musclesTherefore spirometer traces are Therefore spirometer traces are not good predictors of training or not good predictors of training or fitness because lung size/volume do fitness because lung size/volume do not determine fitness (these are not determine fitness (these are largely genetic and not adapted due largely genetic and not adapted due to training)to training)

Gaseous exchange becomes efficient

External Respiration - increased capilliarisation surrounding alveoli – more opportunity for gaseous exchange to occur, more O2 enters the blood

Internal Respiration – increase in myoglobin within the muscles (this carries O2 to mitochondria), therefore leading to improved efficiency of energy production.

Describe the chemical, physical Describe the chemical, physical and neural changes that cause a and neural changes that cause a

change in our breathing rate.change in our breathing rate. Chemical – Increase in CO2, increase in acidity Detected by chemoreceptors Physical – Movement of muscles and joints Detected by proprioreceptors Also stretch receptors in lungs, temperature receptors

detect changes Neural – Nervous control Messages sent to the medulla (respiratory control centre) Messages to send respiratory muscles via sympathetic

nervous system.

Respiratory System so Respiratory System so far . . .far . . .

1. What is the Oxygen-Haemoglobin Disassociation Curve?

2. What happens to the curve during exercise?

3. What causes this to happen?4. What are the effects of the curve

shifting to the right?5. What changes occur to the respiratory

system as a result of training?

Lung Volumes (Average male) ** Learn

Volume Name Description Value at Rest (ml)

Change during

Exercise

Tidal Volume (TV)

Amount of air breathed in or out per breath

500 Increases

Inspiratory Reserve Volume

(IRV)

Maximal amount of air forcibly inspired in

addition to tidal volume

3100 Decreases

Expiratory Reserve Volume

(ERV)

Maximal amount of air forcibly expired in

addition to tidal volume

1200 Decreases

Vital Capacity (VC)

Maximal amount of air exhaled after a maximal

inspiration(TV + IRV + ERV)

4800 Slight

Residual Volume (RV)

Amount of air left in the lungs after a maximal

expiration

1200 None

Total Lung Capacity (TV)

Vital Capacity plus residual volume

(TV + IRV + ERV + RV)

6000 none

Effects of Exercise on Volumes

At rest, lungs are ventilated at approx. 6 Litres per minute During “steady state” endurance exercise maximal ventilation

is about 80-100 Litres per minute (males) and 45-80 Litres per minute (females) – smaller lungs!

Brief maximal exercise (800m race) rates may increase to 120-140 Litres per minute

BREATHING RATES – rise from 12 per minute to 45 per minute during strenuous exercise

Depth of respiration can increase from 0.5 litres per breath to 2.5 litres per breath

Training will usually result in little or no change in pulmonary function. However, swimmers may experience some increase in vital capacity and maximal breathing capacity (breathing

against resistance of the water)Comparison of marathon runners and sedentary subjects showed

no difference in actual lung functions (FEV1, etc)

Summary The respiratory system functions to deliver O2 to the lungs and

remove CO2 The system consists of the nose, trachea, larynx, bronchial tree

and lungs Inspiration occurs when air is drawn into the lungs by the

reduction of the pressure caused by an increase in the size of the thoracic cavity

Expiration occurs when the pressure increases as the size of the thoracic cavity decreases and air is forced out

During normal breathing inspiration is produced by the activity of the diaphragm and intercostal muscles

During exercise both the rate and depth of breathing increase Respiration is controlled by the MEDULLA of the brain Total Lung Capacity = Tidal Volume + Inspiratory Reserve

Volume + Expiratory Reserve Volume and Residual Volume (6000ml)