Date post: | 17-Dec-2015 |
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ResveratroloResveratrolo
Ligand Induces a Conformational Change in the LBD that Repositions helix 12
No Ligand Agonist
NR Antagonists Alter the Position of Helix 12
No Ligand Agonist(ER)
Antagonist(ER)
PHENOL
OH
•>100,000 Compounds>100,000 Compounds
•classified according to basic classified according to basic skeletal structureskeletal structure
•acidicacidic
•Participates in oxidation-Participates in oxidation-reduction reactions reduction reactions
Polyphenol content
Total polyphenolsTotal polyphenols
Red grape, Red grape, aveave. . 5500 mg/kg5500 mg/kg
Red wineRed wine 700–4000 700–4000 mg/Lmg/L
White grape, White grape, aveave. . 4000 mg/kg4000 mg/kg
White wineWhite wine 150-400 150-400 mg/Lmg/L
Vascular benefits Quercetin, catechin, resveratrolQuercetin, catechin, resveratrol
• Inhibition of platelet aggregationInhibition of platelet aggregation
• Inhibition of LDL oxidation (plaque)Inhibition of LDL oxidation (plaque)
•
• Vasodilation
• Inhibition of vasoconstriction (tannins)
Anti-carcinogenic propertiesAnti-carcinogenic properties
• Stilbenes inhibit cell proliferationStilbenes inhibit cell proliferation
• Association with decreased colon Association with decreased colon cancercancer
• Inhibition of non-melanoma skin cancer Inhibition of non-melanoma skin cancer -resveratrol-resveratrol
• Estrogenic effect-resveratrol +/-Estrogenic effect-resveratrol +/-
Resveratrolo