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The Editors are extremely grateful to the
Reviewers 1990following scientists
Development in 1990. We firmly believe that it is the qualitySusan AbmayrEileen AdamsonJohn AitkenMike AkamRosemary AkhurstHenn AlexandraFred AltDavid AndersonRobert AngererPeter ArmstrongMike AshburnerRudi BallingMichael BateRosa BeddingtonDavid BeebeRuth BellaiisDorothy BennettRobert BenoitDavid BentleyMerton BemfieldMariann BienzDavid BillingtonThierry BogaertE. BoncinelliJean-Claude BoucautT. BraunPaul BnckellL. BrinkleyJeremy BrockesMarianne Bronner-FraserDanny BrowerJeremy BrownKen BrownMichael BrownPhilippe BniletMargaret BuckinghamClayton BuckSteve BurdenPaul BurgoyneWilliam BusaCarlos CabreraGerard CampbellJ. A. Campos-OrtegaBruce CarlsonAdelaide CarpenterSean CarrollJordi CasanovaBruce CattanachStanley CaveneyConnie CepkoPierre ChambonAnn ChamfleyHarry CharltonTun CheekLan Bo ChenRuth Chiquet-EhrismannW. K. ChoMargaret ClarkeEnrico CoenJim CohenAlan ColmanJonathan CookeGeoff CookAndy CoppJohn CouchmanDavid CntchleyGerald CunhaCaroline DamskyMichael DanilchikEric Davidson
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PaulLaskoKirsn'e LawsonNicole Le DouarinHenry LeeseRuth LehmannJulian LewisLaura LillienRobin LoveU-BadgeCecilia LoWilliam LucasJohn LucocqAndrew LumsdenMary LyonMalcolm MadenCatherine Magill-SolcTerry MagnusonRoger MarkwaldBernard MaroAlfonso Martinez AriasGail MartinPaul MartinYoshioMasuiAndrew MatusMichael McKeownAnn McLarenAndy McMahonThomas MeedelIan MeuierzhagenElhot MeyerowitzAlan MichelsonJeffrey MillerJonathan MindenRhonaMirskyEd MitraniJay MittenthalUrsula MittwochMarekMlodzikJuan ModolellTun MohunG. MoKneuxMarilyn MonkSally MoodyRandy MoonHarry MooreMalcolm MooreBob MoorGines MorataSergio MorenoKimberry MowryAnn MudgeMartin MullerDennis MurphyThomas MusaBemado Nadal-GinardShunji NatoriTunothy NelsonS. A. NewmanJ. G. NichollsRobert NickellsJ F. NicolasMarkNoWeM. NoUJennifer NormanlyW. E. NorrisR. F. OliverBjora ObenMary OsbornMaureen OwenMike O'ConnorHeather O'Keefe
G. T. O'NeflS. Paine-SaundersRenato ParoRoger PatientMats PaulssonMartin PeraJean-Qaude PerriardHugh PerryGordon PetersJ. PiatigorskyChristopher PottenJack PriceJ. QuiqleyMartin RaffJeremy RashbassSohaila RastanS. ReichlinMarilyn RenfreeR. Renkawitz-PohlGuy Richardson
• A. RizzinoAnthony RobardsLiz RobertsonVeronica RobertsMike RobertsJanet RossantJoel RothmanJoan RudennanAriel Ruiz i AltabaBarbara RuskuiUrs RuushauserJosh SanesTom SargentDavid SassoonLauri SaxenThomas SchedlU. SchiblerJohn SchimentiGary SchoenwolfPaul SchofieldH. ScholerGerald SchreiberReinhard SchuhTrudi SchupbachG. SchUtzM. E. SchwabJ. ScottMarty ShanklandColin SharpePaulSharpePeter ShawPhil ShaysPeter SheltonJ. ShumanEthan SignerWillys SilversPatricia SimpsonHazel SiveJonathan SlackHarold SlavkinAlan SmithAustin SmithJim SmithDennis SmithMalcolm SolurshEd SouthernPierre SpiererMichael SpornRobSteeleMonica Steinmann
Herman StellerEdwin StephensonQaudio StemDavid StocumSidney StricklandGary StruhlDaniel St. JohnstonTung-tien SunAzim SuraniIan SussexKathySvobodaChff TabinMasatoshi TakeichiJam TataDiethard TautzMike TaylorG. M. TechnauMarie-Armee TeilletTen TeiziJanTesarikMarc Tessier-LevingeIrma ThesleffJean-Paul ThieryCheryl TickleAndrew TomhnsonRichard TreismanAnthony TrewavasJohn TuckerAna VallesJudith VerbekePeter VizeKristme VogelTom VogtE. VurioTrevor WangAndrew WardAnne WarnerRichard WarnRahul WarriorPaul WassarmanFiona WattR. WeberDan WeeksMonte WesterfieldJames WestonJohn WestMichael WhitakerJohn WhiteRob WhiteMalcolm WhitmanDavid WhittinghamCaroline WigleyPeter WigmoreMike WilcoxD. C. WilkinsonDerek WilliamsonJ. WilliamsPaul WilsonFred WiltLewis WolpertGordon WongHugh WoodlandMichael WormingtonJohn WozneyChristopher WrightKen YamadaTuneo YamadaJunying YuanPeggy ZelenkaC. ZiHer
DevelopmentVolume 111 1991
Editor in Chief
European Editors
Chris Wylie (Cambridge)
Richard Gardner (Oxford)Walter Gehring (Basel)
Peter Lawrence (Cambridge)Keith Roberts (Norwich)
USA Editors Doug Melton (Harvard)Tom Jessell (Columbia)
Gerry Rubin (Berkeley)
EditorialAdvisory Board
Eileen Adamson (La Jolla)Michael Akam (Cambridge)Michael Bate (Cambridge)Rosa Beddington (Edinburgh)Marianne Bronner-Fraser (Irvine)Clayton Buck (Wistar Institute)Alan Colman (Birmingham)Eric Davidson (Pasadena)Alun Davies (London)Francoise Dieterlen (Nogent-sur-Marne)John Ellis (Warwick)Gary Felsenfeld (Bethesda)Richard Firtel (San Diego)Joseph Frankel (Iowa)Michael Freeling (Berkeley)John Gerhart (Berkeley)Peter Goodfellow (London)Peter Gruss (G6ttingen)John Gurdon (Cambridge)John Heath (Oxford)Brigid Hogan (Vanderbilt)Nigel Holder (London)Robert Horvitz (MIT)Phil Ingham (Oxford)Herbert JSckle (Munich)Rudolph Jaenisch (Whitehead, MIT)William Jeffery (Austin)Martin Johnson (Cambridge)Klaus Kalthoff (Austin)
Robert Kay (Cambridge)Judith Kimble (Madison)Charles Kimmel (Eugene)Klaus Kratochwil (Salzburg)Ruth Lehmann (Whitehead, MIT)Julian Lewis (Oxford)Andrew Lumsden (London)Mary Lyon (Didcot)Terry Magnuson (Case Western)Gail Martin (San Francisco)Bjorn Olsen (Harvard)Scott Poethig (Pennsylvania)Martin Raff (London)Elizabeth Robertson (Columbia)Janet Rossant (Toronto)Joan Ruderman (Duke)Matthew Scott (Stanford)Jonathan Slack (Oxford)Jim Smith (London)Michael Sporn (Bethesda)Claudio Stern (Oxford)Gary Struhl (Columbia)Chris Summerville (Michigan)Azim Surani (Cambridge)Masatoshi Takeichi (Kyoto)Peter Thorogood (London)David Weisblat (Berkeley)Richard Whittaker (Woods Hole)Jeff Williams (ICRF, Clare Hall)
Published by The Company of Biologists Limited, Cambridge
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ContentsVolume 111 1991
Young, P. E., Pesacreta, T. C. and Kiehart, D. P.Dynamic changes in the distribution ofcytoplasmic myosin during Drosophilaembryogenesis
Ranscht, B. and Bronner-Fraser, M.T-cadherin expression alternates with migratingneural crest cells in the trunk of the avian embryo
Condic, M. L., Fristrom, D. and Fristrom, J. W.Apical cell shape changes during Drosophilaimaginal leg disc elongation: a novelmorphogenetic mechanism
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23
Maden, M., Hunt, P., Eriksson, U., Kuroiwa, A.,Krumlauf, R. and Summerbell, D.Retinoic acid-binding protein, rhombomeres andthe neural crest 35
Ruberte, E., Dolle\ P., Chambon, P.and Moniss-Kay, G.Retinoic acid receptors and cellular retinoid •binding proteins. II. Their differential pattern oftranscription during early morphogenesis inmouse embryos 45
Murphy, P. and Hill, R. E.Expression of the mouse labial-\ike homeobox-containing genes, Hox 2.9 and Hox 1.6, duringsegmentation of the hindbrain
Sobis, H., Verstuyf, A. and Vandeputte, M.Endodermal origin of yolk-sac-derived teratomas
Prokop, A. and Technau, G. M.The origin of postembryonic neuroblasts in theventral nerve cord of Drosophila melanogaster
Bang, A. G., Hartenstein, V. and Posakony, J. W.Hairless is required for the development of adultsensory organ precursor cells in Drosophila
Ayer-Le Lievre, C , Stahlbom, P.-A.and Sara, V. R.Expression of IGF-I and -II mRNA in the brainand craniofacial region of the rat fetus
Schmid, P., Cox, D., Bilbe, G., Maier, R.and McMaster, G. K.Differential expression of TGF /SI, pi and pigenes during mouse embryogenesis
Millan, F. A., Denhez, F., Kondaiah, P.and Akhurst, R. J.Embryonic gene expression patterns of TGF pi,pi and pi suggest different developmentalfunctions in vivo 131
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Cunha, G. R., Young, P., Higgins, S. J.and Cooke, P. S.Neonatal seminal vesicle mesenchyme induces anew morphological and functional phenotype inthe epithelia of adult ureter and ductus deferens 145
Levi, G., Gumbiner, B. and Thiery, J. P.The distribution of E-cadherin during Xenopuslaevis development 159
Sun, F. Z. and Moor, R. M.Nuclear-cytoplasmic interactions during ovineoocyte maturation 171
de Pomerai, D. I., Ip, W. K., McLaughlin, M.and Perry, K. C.Expression in non-lens tissues of an enzymeactivity related to the 'lens-specific' protein, 6crystallin 181
Linsenmayer, T. F., Chen, Q., Gibney, E.,Gordon, M. K., Marchant, J. K., Mayne, R.and Schmid, T. M.Collagen types IX and X in the developing chicktibiotarsus: analyses of mRNAs and proteins 191
Cooke, J. and Wong, A.Growth-factor-related proteins that are inducersin early amphibian development may mediatesimilar steps in amniote (bird) embryogenesis 197
Trautman, M. S., Kimelman, J. and Bernfield, M.Developmental expression of syndecan, anintegral membrane proteoglycan, correlates withcell differentiation 213
Bloch-Gallego, E., Huchet, M., El M'Hamdi, H.,Xie, F.-K., Tanaka, H. and Henderson, C. E.Survival in vitro of motoneurons identified orpurified by novel antibody-based methods isselectively enhanced by muscle-derived factors 221
Lyons, G. E., Buckingham, M. E., Tweedie, S.and Edwards, Y. H.Carbonic anhydrase III, an early mesodermalmarker, is expressed in embryonic mouse skeletalmuscle and notochord 233
Smith, S. M. and Eichele, G.Temporal and regional differences in theexpression pattern of distinct retinoic acidreceptor-/? transcripts in the chick embryo 245
Fisher, C , Byers, M. R., Iadarola, M. J.and Powers, E. A.Patterns of epithelial expression of Fos proteinsuggest important role in the transition fromviable to cornified cell during keratinization 253
Contents
Wiles, M. V. and Keller G.Multiple hematopoietic lineages develop fromembryonic stem (ES) cells in culture 259
Mackenzie, A., Leeming, G. L., Jowett, A. K.,Ferguson, M. W. J. and Sharpe, P. T.The homeobox gene Hox 7.1 has specific regionaland temporal expression patterns during earlymurine craniofacial embryogenesis, especiallytooth development in vivo and in vitro 269
Davis, C. A., Holmyard, D. P., Millen, K. J.and Joyner, A. L.Examining pattern formation in mouse, chickenand frog embryos with an En-specific antiserum 287
Fernandez, D. E., Turner, F. R.and Crouch, M. L.In situ localization of storage protein mRNAs indeveloping meristems of Brassica napus embryos 299
Ginsberg, D., DeSimone, D. and Geiger, B.Expression of a novel cadherin (EP-cadherin) inunfertilized eggs and early Xenopus embryos 315
Takahashi, Y. and Nogawa, H.Branching morphogenesis of mouse salivaryepithelium in basement membrane-likesubstratum separated from mesenchyme by themembrane filter 327
Shi, X., Lu, L., Qiu, Z., He, W. and Frankel, J.Microsurgically generated discontinuities provokeheritable changes in cellular handedness of aciliate, Stylonychia mytilus 2>2>1
Boulter, C. A., Aguzzi, A., Williams, R. L.,Wagner, E. F., Evans, M. J. and Beddington, R.Expression of v-src induces aberrant developmentand twinning in chimaeric mice 357
Eldon, E. D. and Pirrotta, V.Interactions of the Drosophila gap gene giantwith maternal and zygotic pattern-forming genes 367
Yasuda, G. K., Baker, J. and Schubiger, G.Independent roles of centrosomes and DNA inorganizing the Drosophila cytoskeleton 379
Boulet, A. M., Lloyd, A. and Sakonju, S.Molecular definition of the morphogenetic andregulatory functions and the cis-regulatoryelements of the Drosophila Abd-B homeotic gene 393
Irvine, K. D., Helfand, S. L. and Hogness, D. S.The large upstream control region of theDrosophila homeotic gene Ultrabithorax 407
Swalla, B. J., Badgett, M. R. and Jeffery, W. R.Identification of a cytoskeletal protein localized inthe myoplasm of ascidian eggs: localization ismodified during anural development 425
Sanchez-Herrero, E.Control of the expression of the bithorax complexgenes abdominal-A and Abdominal-B by cis-regulatory regions in Drosophila embryos 437
Lyons, G. E., Buckingham, M. E.and Mannherz, H. G.tf-actin proteins and gene transcripts arecolocalized in embryonic mouse muscle 451
Wanaka, A., Milbrandt, J. and Johnson, E. M.Expression of FGF receptor gene in ratdevelopment 455
Drysdale, T. A. and Elinson, R. P.Development of the Xenopus laevis hatchinggland and its relationship to surface ectodermpatterning 469
Perkins, A. S., Mercer, J. A., Jenkins, N. A.and Copeland, N. G.Patterns of Evi-1 expression in embryonic andadult tissues suggest that Evi-1 plays an importantregulatory role in the mouse development 479
Brown, R. and Brockes, J. P.Identification and expression of a regeneration-specific homeobox gene in the newt limbblastema 489
Ferretti, P., Brockes, J. P. and Brown, R.A newt type II keratin restricted to normal andregeneration limbs and tails is responsive toretinoic acid 497
Minkoff, R., Parker, S. B. and Hertzberg, E. L.Analysis of distribution patterns of gap junctionsduring development of embryonic chick facialprimordia and brain 509
Godsave, S. F. and Slack, J. M. W.Single cell analysis of mesoderm formation in theXenopus embryo 523
Jones, C. M., Lyons, K. M. and Hogan, B. L. M.Involvement of Bone Morphogenetic Protein-4(BMP-4) and Vgr-1 in morphogenesis andneurogenesis in the mouse 531
Miwa, Y., Atsumi, T., Imai, N. and Ikawa, Y.Primitive erythropoiesis of mouseteratocarcinoma stem cells PCC3/A/1 in serum-free medium 543
Hopwood, N. D., Pluck, A. and Gurdon, J. B.Xenopus Myf-5 marks early muscle cells and canactivate muscle genes ectopically in early embryos 551
Mazarakis, N. D., Nelki, D., Lyon, M. F.,Ruddy, S., Evans, E. P., Freemont, P.and Dudley, K.Isolation and characterisation of a testis-expresseddevelopmentally regulated gene from the distalinversion of the mouse f-complex 561
Contents
Sasaki, H., Hamada, T., Ueda, T., Seki, R.,Higashinakagawa, T. and Sakaki, Y.Inherited type of allelic methylation variations ina mouse chromosome region where an integratedtransgene shows methylation imprinting 573
Perris, R., Krotoski, D., Lallier, T., Domingo, C ,Sorrell, J. M. and Bronner-Fraser, M.Spatial and temporal changes in the distributionof proteoglycans during avian neural crestdevelopment 583
Kraut, R. and Levine, M.Spatial regulation of the gap gene giant duringDrosophila development 601
Kraut, R. and Levine, M.Mutually repressive interactions between the gapgenes giant and Kruppel define middle bodyregions of the Drosophila embryo 611
Kelso-Winemiller, L. C. and Winkler, M. M.'Unmasking' of stored maternal mRNAs and theactivation of protein synthesis at fertilization insea urchins 623
Stocker, K. M., Sherman, L., Rees, S.and Ciment, G.Basic FGF and TGF-ySl influence commitment tomelanogenesis in neural-crest-derived cells ofavian embryos 635
Pomeranz, H. D., Rothman, T. P.and Gershon, M. D.Colonization of the post-umbilical bowel by cellsderived from the sacral neural crest: direct tracingof cell migration using an intercalating probe anda replication-deficient retrovirus 647
Blackman, R. K., Sanicola, M., Raftery, L. A.,Gillevet, T. and Gelbart, W. M.An extensive 3' cw-regulatory region directs theimaginal disk expression of decapentaplegic, amember of the TGF-/J family in Drosophila 657
Goh, P.-Y. and Bogaert, T.Positioning and maintenance of embryonic bodywall muscle attachments in C. elegans requires themup-1 gene 667
Flamme, I., Schulze-Osthoff, K. and Jacob, H. J.Mitogenic activity of chicken chorioallantoic fluidis temporally correlated to vascular growth in thechorioallantoic membrane and related tofibroblast growth factors 683
Andujar, M. B., Couble, P., Couble, M.-L. andMagloire, H.Differential expression of type I and type IIIcollagen genes during tooth development 691
Desbiens, X., Qulva, C , Jaffredo, T., Stlhelin, D.and Vandenbunder, B.The relationship between cell proliferation andthe transcription of the nuclear oncogenes c-myc,c-myb and c-ets-1 during feather morphogenesisin the chick embryo 699
Hemmati-Brivanlou, A., de la Torre, J. R.,Holt, C. and Harland, R. M.Cephalic expression and molecularcharacterization of Xenopus En-2 715
Hornbruch, A. and Wolpert, L.The spatial and temporal distribution ofpolarizing activity in the flank of the pre-limb-budstages in the chick embryo 725
Dudley, M. and Poethig, R. S.The effect of a heterochronic mutation, Teopod2,on the cell lineage of the maize shoot 733
Moore, J. W., Dionne, C , Jaye, M.and Swain, J. L.The mRNAs encoding acidic FGF, basic FGF,and FGF receptor are coordinatelydownregulated during myogenic differentiation 741
Thomas, U., Speicher, S. A. and Knust, E.The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complexexpression pattern in embryos and wing discs 749
Kubiak, J., Paldi, A., Weber, M. and Maro, B.Genetically identical parthenogenetic mouseembryos produced by inhibition of the firstmeiotic cleavage with cytochalasin D 763
Rowe, A., Eager, N. S. C. and BrickeU, P. M.A member of the RXR nuclear receptor family isexpressed in neural-crest-derived cells of thedeveloping chick peripheral nervous system 771
Jermyn, K. A. and Williams, J. G.An analysis of culmination in Dictyostelium usingprestalk and stalk-specific cell autonomousmarkers 779
Schlosshauer, B., Grauer, D., Dutting, D.and Vanselow, J.Expression of a novel Mtiller glia specific antigenduring development and after optic nerve lesion
Radice, G., Lee, J. J. and Constantini, F.H/358, an insertional mutation affecting earlypostimplantation development of the mouseembryo
Jessus, C , Rime, H., Haccard, O., van Lint, J.,Goris, J., Merlevede, W. and Ozon, R.Tyrosine phosphorylation of p34cdci and p42during meiotic maturation of Xenopus oocyte.Antagonistic action of okadaic acid and 6-DMAP
789
801
813
Contents
Saiga, H., Mizokami, A., Makabe, K. W.,Satoh, N. and Mita, T.Molecular cloning and expression of a novelhomeobox gene AHoxl of the ascidian,Halocynthia roretzi 821
Angres, B., Miiller, A. H. J., KeUermann, J.and Hausen, P.Differential expression of two cadherins inXenopus laevis 829
Danilchik, M. V. and Denegre, J. M.Deep cytoplasmic rearrangements during earlydevelopment in Xenopus laevis 845
Serbedzija, G. N., Burgan, S., Fraser, S. E.and Bronner-Fraser, M.Vital dye labelling demonstrates a sacral neuralcrest contribution to the enteric nervous systemof chick and mouse embryos 857
Noden, D. M.Origins and patterning of avian outflow tractendocardium 867
Kawabe, T. T., Rea, T. J., Flenniken, A. M.,Williams, B. R. G., Groppi, V. E. and Buhl, A. E.Localization of TIMP in cycling mouse hair 877
Seaver, E. C , Karlstrom, R. O.and Bastiani, M. J.The restricted spatial and temporal expression ofa nervous-system-specific antigen involved in axonoutgrowth during development of the grasshopper 881
Frank, E. and Sanes, J. R.Lineage of neurons and glia in chick dorsal rootganglia: analysis in vivo with a recombinantretrovirus 895
Hatanaka, K. and Okada, M.Retarded nuclear migration in Drosophilaembryos with aberrant F-actin reorganizationcaused by maternal mutations and by cytochalasintreatment 909
Chisholm, A.Control of cell fate in the tail region of C. elegansby the gene egl-5 921
Nishiyama, A., Dahlin, K. J. and Stallcup, W. B.The expression of NG2 proteoglycan in thedeveloping rat limb 933
Cheah, K. S. E., Lau, E. T., Au, P. K. C.and Tam, P. P. L.Expression of the mouse arl(II) collagen gene isnot restricted to cartilage during development 945
Wood, A., Ashhurst, D. E., Corbett, A.and Thorogood, P.The transient expression of type II collagen attissue interfaces during mammalian craniofacialdevelopment 955
Conlon, F. L., Barth, K. S. and Robertson, E. J.A novel retrovirally induced embryonic lethalmutation in the mouse: assessment of thedevelopmental fate of embryonic stem cellshomozygous for the 413.d proviral integration 969
Alberga, A., Boulay, J.-L., Kempe, E.,Dennefeld, C. and Haenlin, M.The snail gene required for mesoderm formationin Drosophila is expressed dynamically inderivatives of all three germ layers 983
Torrence, S. A.Positional cues governing cell migration in leechneurogenesis 993
Rowe, A., Richman, J. M. and Brickell, P. M.Retinoic acid treatment alters the distribution ofretinoic acid receptor-/? transcripts in theembryonic chick face 1007
Palmer, S. J. and Burgoyne, P. S.XY follicle cells in the ovaries of XO/XY andXO/XY/XYY mosaic mice 1017
Hashimoto, C , Gerttula, S. and Anderson, K. V.Plasma membrane localization of the Toll proteinin the syncytial Drosophila embryo: importanceof transmembrane signaling for dorsal-ventralpattern formation 1021
Peifer, M., Rauskolb, C , Williams, M.,Riggleman, B. and Wieschaus, E.The segment polarity gene armadillo interactswith the wingless signaling pathway in bothembryonic and adult pattern formation 1029
Christian, J. L., McMahon, J. A.,McMahon, A. P. and Moon, R. T.Xwnt-8, a Xenopus Wnt-l/int-l-related generesponsive to mesoderm-inducing growth factors,may play a role in ventral mesodermal patterningduring embryogenesis 1045
Harvey, M. B. and Kaye, P. L.IGF-2 receptors are first expressed at the 2-cellstage of mouse development 1057
Hardy, R. and Reynolds, R.Proliferation and differentiation potential of ratforebrain oligodendroglial progenitors both invitro and in vivo 1061
Glick, A. B., McCune, B. K., Abdulkarem, N.,Flanders, K. C , Lumadue, J. A., Smith, J. M.and Sporn, M. B.Complex regulation of TGF /J expression byretinoic acid in the vitamin A-deficient rat 1081
Huang, F., Dambly-Chaudiere, C. and Ghysen, A.The emergence of sense organs in the wing discof Drosophila 1087
Contents
Ott, M.-O., Bober, E., Lyons, G., Arnold, H.and Buckingham, M.Early expression of the myogenic regulatorygene, myf-5, in precursor cells of skeletal musclein the mouse embryo 1097
Pravtcheva, D. D., Adra, C. N. and Ruddle, F. H.Timing of paternal Pgk-1 expression in embryosof transgenic mice 1109
Parkhurst, S. M. and Ish-Horowicz, D.Mis-regulating segmentation gene expression inDrosophila . 1121
Hunt, P. A. . . .,.Survival of XO mouse fetuses: effect of parentalorigin of the X* chromosome or uterineenvironment? 1137
Schniirch, H. and Risau, W.Differentiating and mature neurons express theacidic fibroblast growth factor gene during chickneural development 1143
Jones, R.Interaction of zona pellucida glycoproteins,sulphated carbohydrates and synthetic polymerswith proacTosin, the putative egg-binding proteinfrom mammalian spermatozoa 1155
Urch, U. A. and Patel, H.The interaction of boar sperm proacrosin with itsnatural substrate, the zona pellucida, and withpolysulfated polysaccharides 1165
Weeks, D. L., Walder, J. A. and Dagle, J. M.Cyclin B mRNA depletion only transientlyinhibits the Xenopus embryonic cell cycle 1173
Su, M.-W., Suzuki, H. R., Solursh, M.and Ramirez, F.Progressively restricted expression of a newhomeobox-containing gene during Xenopus laevisembryogenesis 1179
Index of Authors and Titles
Subject Index
1189
1195
INFORMATION ABOUT THE JOURNALDEVELOPMENT (ISSN 0950-1991) is a continuation of Journal of Embryology and Experimental Morphology (ISSN 0022-0752).
f DevelopmentThe aim of Development is to act as aforum for all research that offers agenuine insight into mechanisms ofdevelopment. Manuscripts will beconsidered primarily with respect to thisaim.
Studies on both plant and animaldevelopment are welcome and can befocused upon any aspect of thedevelopmental process, at all levels ofbiological organization from themolecular and cellular to the tissuelevels.
f What Development offers(i) Wide international circulation(ii) Fast publication - average 13 weeksfrom acceptance(iii) Fast editorial processing(iv) No page charges(v) 200 free reprints(vi) Free colour reproduction (at theeditor's discretion).
I Rapid publicationlHMHIDevelopment now offers rapidpublication (average 9 weeks fromacceptance): the following criteriaapply:(i) the revised manuscript isaccompanied by a corresponding word-processor disk(ii) no colour plates(iii) author does not require to seeproofs(iv) 200 free reprints only(v) manuscript conforms to journalstyle i.e. no subediting necessary - seeInformation for contributors,(vi) Figures are labelled in journalstyle.
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Number of issues
Development in 1991 will have 12normal issues and 2 caseboundsupplements. The 12 normal issues willbe in the form of 3 volumes (111, 112,113) each of 4 parts. In 1991 theSupplements will be 'Molecular andCellular Basis of Pattern Formation'and 'Developmental Neurobiology'.
Orders 'ifliOrders for 1991, which can be in £Sterling/Dollars or using Access/Visacredit cards, should be sent to PortlandPress Ltd, PO Box 32, Commerce Way,Colchester CO2 8HP, UK[telephone Colchester (0206) 46351;24-hour ordering by Fax (0206) 549331- USA 44 206 549331] or to yournormal agent or bookseller.Orders must be accompanied bypayment.
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(i) Authors may make copies oftheir own papers in this journalwithout seeking permission fromThe Company of Biologists Limited,provided that such copies are for freedistribution only: they must not besold.
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INFORMATION FOR CONTRIBUTORSManuscripts
Send to: Development Editorial Office,Dept of Zoology, University ofCambridge, Downing St, CambridgeCB2 3EJ, UK. Tel: (0223) 311789 ordirect to one of the editors.
USA papers should be sent direct to:Dr D. Melton, Department ofBiochemistry and Molecular Biology,Harvard University, 7 Divinity Avenue,Cambridge, MA 02138, USA,Dr G. Rubin, Department of Molecularand Cell Biology, Box 539, LSABuilding, University of California,Berkeley, CA 94720, USA,or Dr T. Jessell, Center forNeurobiology and Behavior, ColumbiaUniversity, 722 West 168th Street,New York, NY 10032, USA.
European papers can be sent to:Dr W. J. Gehring, Department of CellBiology, Biozentrum, University ofBasel, Klingelbergstrasse 70, CH-4056,Basel, Switzerland.
Manuscripts should be in English,typewritten, double spaced, on one sideof the paper, and the pages numbered.Papers should be fully ready for press,since revision in proof will not bepossible. The author is requested toprovide three copies of the typescriptand figures, and should keep a copy.
K Author's disksDevelopment can use author's word-processor disks (5i and 3i" instead ofrekeying accepted articles. Thisincreases both the speed and accuracyof proof production. With your letter ofprovisional acceptance, you will be sentfull instructions on formatting andsaving your manuscript on disk. Pleasesend a copy of your disk with 2 printedcopies of your final revised manuscript.Disks will be returned.
Authors will receive 200 reprints free of.charge and may order additional copies 'when proofs are returned.
A short title of not more than 40characters, for use as page headings,should be supplied and at least 3 keywords for indexing papers.A summary must be provided at thebeginning of the text. It should notexceed 500 words. Acknowledgementsshould be placed before the list ofreferences.The list of references must be given inalphabetical order of author's names.The titles of journals should beabbreviated in accordance with theWorld List of Scientific Periodicals,4th edn (1963). The following style isused:
Lawrence, P. and Johnston, P. (1988).Cell lineage of the Drosophilaabdomen. Development 99,197-208.
Rossant, J. (1977). Cell commitmentin early rodent development. InDevelopment in Mammals, vol. 2(ed. M. H. Johnson), pp. 119-150.Amsterdam: North Holland.
Citations in the text are given in thefollowing form: Jones and Smith(1960) or (Jones and Smith, 1960).Where there are more than twoauthors citations should be in theform (Jones et al. 1960). Where morethan one paper by the same author(s)have been published in the same yearthey are cited as Jones (1960a), Jones(1960b) etc.
Footnotes should be avoided whereverpossible.
Tables 9 H H H H IPlease submit on separate sheetstogether with their titles and legends.
Proofs fl^H^^HHAuthors will receive two sets ofproofs, one for correction and returnto Editorial Office. Authors may berequired to pay for alterations inproof other than those needed tocorrect printer's errors.
^exTngures/photographsThese should be numbered in a singleseries (Fig. 1, Figs 2, 3 etc), in theorder in which they are referred to inthe text. Legends for all illustrationsshould be typed together, separatelyfrom the main text. Authors shouldsubmit three copies for reviewers.Copies of the photographic plates mustbe of suitable standard for reviewers tojudge the quality of the work;photocopies are not acceptable.Original figures should be kept by theauthor until the manuscript has beenaccepted for publication.Text figures and photographs ideallyshould be at final size and occupyeither 1 or 2 columns. The maximumprinted size for illustrations is210mmxl68mm for a whole page or210mmx81 mm for a single column.Labelling can-be inserted by the authorproviding that the lattering conforms tojournal style and size. Otherwiselabelling should be indicated on aduplicate marked set of prints or on atracing-paper overlay bearingaccurately marked outlines of theobjects indicated. Figure parts shouldbe labelled in upper case and letteringon the plates should be in lower case.Magnification should be indicated,where relevant, by a scale line on orbeside the illustration. Each illustrationshould have the name of the authorand the figure number written on theback, together with indication oforientation and any proposed reductionin size.
lour plates ^ ^ HThese can be reproduced free of chargeat the discretion of the editor. Anycharge for excessive use of colour willalso be at the editor's discretion.
Copyright flBHHIn order to give The Company ofBiologists Limited authority to dealwith matters of copyright, authors willbe required to assign to them the copy-right of any article published in thejournal.
The College of Physicians & SurgeonsColumbia University
June 28 to 30,1991Harriman, New York
P&S Biomedical Sciences Symposium
Cell-Cell Signalling inVertebrate Development
TopicsInductionCell MigrationPattern formationCell-cell contactsGradients and diffusible signalsTranscription factors
OrganizersElizabeth RobertsonFrederick MaxfieldHenry Vogel
For registration informationDr. Frederick MaxfieldDepartment of PathologyCollege of Physicians & SurgeonsColumbia University630 West 168 StreetNew York, NY 10032
FAX: 212-305-5498
SpeakersAlan BernsteinJeremy BrockesFranklin CostantiniIgor DawidJane DoddArgiris EfstratiadisGregor EicheleJohn GurdonMary E. HattenThomas JessellRobb KrumlaufCarol MasonAndrew McMahonLouis F. ReichartClaudio SternMatsatoshi TakeichiThomas VoertA 1 1 Vr I I I fc^ fcT • V b v
Monte WesterfieldDavid WilkinsonEdward Ziff
Xenopusembryology
-basic embryological techniques
-mesoderm-inducing factor assays
-lineage labelling
-wholemount immunocytochemistry
- in situ hybridization
Organizers: Jonathan SlackJim Smith
Venue: Department of Zoology and Wadham College,Oxford University, UK. September 8-15 1991.
If you wish to apply to participate, or requirefurther information about the course content, pleasewri te to Dr J.M.W.Slack, I.C.R.F. Developmental BiologyUnit, Department of Zoology, South Parks Road, Oxford0X1 3PS, United Kingdom.
Modern Techniques
in Developmental Biology
A PRACTICAL COURSE25th August - 7th September, 1991
Oxford, UK
The aim of the course is to familiarise participants with new technical advances inDevelopmental Biology, and especially to encourage integration between cellular andmolecular approaches. The number of participants is strictly limited, and places will beawarded on a competitive basis.
Teaching staff invited includes:
Phil Ingham(Oxford)
David Ish-Horowicz(Oxford)
Chuck Kimmel(Oregon)
Robb Krumlauf(London)
Gail Martin(San Francisco)
Liz Robertson(New York)
Ariel Ruiz i Altaba(New York)
Peter Thorogood(London)
Cheryll Tickle(London)
David Wilkinson(London)
Invited lecturers:
N. Le Douann (Nogent-sur-Mame)
P. Grass (Cdttingen)F. Rosa (Paris)
E. Southern (Oxford)M. Wilcox (Cambridge)L. Wolpert (London)
Applications
from postdoctoral scientists or advanced graduatestudents in educational, research or commercial/industrial establishments should be sent by 15th
February, 1991 to one of the organizers:
Peter HollandDepartment of Zoology-South Parks RoadOxford 0X1 3PS, UK
Claudio SternDepartment of AnatomySouth Parks RoadOxford 0X1 30X, UK
and should include a Curriculum Vitae and a briefstatement of research interests. Two referees shouldsupport the application by writing directly to theorganizers. A limited number of bursaries will be
available to assist participants.
Sponsored by: British Society for Developmental Biology, Company of Biologists, Nuffield Foundation,Universities Funding Council and Oxford Centre for Continuing Education.
INFORMATION FOR CONTRIBUTORSManuscripts
Send to: Development Editorial Office,Dept of Zoology, University ofCambridge, Downing St, CambridgeCB2 3EJ, UK. Tel: (0223) 311789 ordirect to one of the editors.
USA papers should be sent direct to:Dr D. Melton, Department ofBiochemistry and Molecular Biology,Harvard University, 7 Divinity Avenue,Cambridge, MA 02138, USA,Dr G. Rubin, Department of Molecularand Cell Biology, Box 539, LSABuilding, University of California,Berkeley, CA 94720, USA,or Dr T. Jessell, Center forNeurobiology and Behavior, ColumbiaUniversity, 722 West 168th Street,New York, NY 10032, USA.
European papers can be sent to:Dr W. J. Gehring, Department of CellBiology, Biozentrum, University ofBasel, Klingelbergstrasse 70, CH-4056,Basel, Switzerland.
Manuscripts should be in English,typewritten, double spaced, on one sideof the paper, and the pages numbered.Papers should be fully ready for press,since revision in proof will not bepossible. The author is requested toprovide three copies of the typescriptand figures, and should keep a copy.
„ Author's disks
Development can use author's word-processor disks (5i and 3i" instead ofrekeying accepted articles. Thisincreases both the speed and accuracyof proof production. With your letter ofprovisional acceptance, you will be sentfull instructions on formatting andsaving your manuscript on disk. Pleasesend a copy of your disk with 2 printedcopies of your final revised manuscript.Disks will be returned.
Reprir
Authors will receive 200 reprints free of.charge and may order additional copies 'when proofs are returned.
A short title of not more than 40characters, for use as page headings,should be supplied and at least 3 keywords for indexing papers.A summary must be provided at thebeginning of the text. It should notexceed 500 words. Acknowledgementsshould be placed before the list ofreferences.The list of references must be given inalphabetical order of author's names.The titles of journals should beabbreviated in accordance with theWorld List of Scientific Periodicals,4th edn (1963). The following style isused:
Lawrence, P. and Johnston, P. (1988).Cell lineage of the Drosophilaabdomen. Development 99,197-208.
Rossant, J. (1977). Cell commitmentin early rodent development. InDevelopment in Mammals, vol. 2(ed. M. H. Johnson), pp. 119-150.Amsterdam: North Holland.
Citations in the text are given in thefollowing form: Jones and Smith(1960) or (Jones and Smith, 1960).Where there are more than twoauthors citations should be in theform (Jones et al. 1960). Where morethan one paper by the same author(s)have been published in the same yearthey are cited as Jones (1960a), Jones(1960b) etc.
Footnotes should be avoided whereverpossible.
Tables 4HHHHIPlease submit on separate sheetstogether with their titles and legends.
Proofs ^ H I ^ H HAuthors will receive two sets ofproofs, one for correction and returnto Editorial Office. Authors may berequired to pay for alterations inproof other than those needed tocorrect printer's errors.
figures/photographsThese should be numbered in a singleseries (Fig. 1, Figs 2, 3 etc), in theorder in which they are referred to inthe text. Legends for all illustrationsshould be typed together, separatelyfrom the main text. Authors shouldsubmit three copies for reviewers.Copies of the photographic plates mustbe of suitable standard for reviewers tojudge the quality of the work;photocopies are not acceptable.Original figures should be kept by theauthor until the manuscript has beenaccepted for publication.Text figures and photographs ideallyshould be at final size and occupyeither 1 or 2 columns. The maximumprinted size for illustrations is210mmxl68mm for a whole page or210mmx81 mm for a single column.Labelling can-be inserted by the authorproviding that the lattering conforms tojournal style and size. Otherwiselabelling should be indicated on aduplicate marked set of prints or on atracing-paper overlay bearingaccurately marked outlines of theobjects indicated. Figure parts shouldbe labelled in upper case and letteringon the plates should be in lower case.Magnification should be indicated,where relevant, by a scale line on orbeside the illustration. Each illustrationshould have the name of the authorand the figure number written on theback, together with indication oforientation and any proposed reductionin size.
These can be reproduced free of chargeat the discretion of the editor. Anycharge for excessive use of colour willalso be at the editor's discretion.
Copyright flBHIIn order to give The Company ofBiologists Limited authority to dealwith matters of copyright, authors willbe required to assign to them the copy-right of any article published in thejournal.
ContentsVolume 111 (4) 1991
Danilchik. M. V. and Denegre, J. M.Deep cytoplasmic rearrangements during early developmentin Xenopus laevis 845
Serbedzija. G. N.. Burgan. S.. Fraser. S. E.and Bronner-Fraser, M.Vital dye labelling demonstrates a sacral neural crestcontribution to the enteric nervous system of chick and mouseembryos I^Kfl^EIHNoden. D. M.Origins and patterning of avian outflow tract endocardium
Kawabe, T. T., Rea, T. J., Flenniken. A. M..Williams, B. R. G.. Groppi. V. E. and Buhl. A. E. ,Localization of TIMP in cycling mouse hair |
Seaver, E. C , Karlstrom, R. O. and Bastiani, M. J.The restricted spatial and temporal expression of a nervous-system-specific antigen involved in axon outgrowth duringdevelopment of the grasshopper
Frank, E. and Sanes, J. R.Lineage of neurons and glia in chick dorsal root ganglia:analysis in vivo with a recombinant retrovirus 895
Hatanaka, K. and Okada, M.Retarded nuclear migration in Drosophila embryos withaberrant F-actin reorganization caused by maternal mutationsand by cytochalasin treatment ^ _ _ _ _ ^ ^ _ _ _ ^ _ 909
Chisholm, A.Control of cell fate in the tail region of C. elegans by the geneegl-5 921
Nishiyama, A., Dahlin. K. J. and Stallcup, W. B.The expression of NG2 proteoglycan in the developing ratlimb 933
Cheah, K. S. E., Lau, E. T., Au, P. K. C. and Tam, P. P. L.Expression of the mouse <i1(ll) collagen gene is not restrictedto cartilage during development 945
Wood, A., Ashhurst. D. E., Corbett, A. and Thorogood. P.The transient expression of type II collagen at tissueinterfaces during mammalian craniofacial development 955
Conlon. F. L.. Barth, K. S. and Robertson, E. J.A novel retrovirally induced embryonic lethal mutation in the 'mouse: assessment of the developmental fate of embryonicstem cells homozygous for the 413d proviral integration 969
Alberga. A.. Boulay. J.-L.. Kempe. E., Dennefeld. C.and Haenlin, M.The snail gene required for mesoderm formation inDrosophila is expressed dynamically in derivatives of all threegerm layers 983
Torrence. S. A.Positional cues governing cell migration in leechneurogenesis
Rowe, A., Richman, J. M. and Bricked, P. M.Retmoic acid treatment alters the distribution of retinoic acidreceptor-/; transcripts in the embryonic chick face J ^ H H 1007
Palmer. S. J. and Burgoyne. P. S.XY follicle cells in the ovaries of XO XY and XO XY XYYmosaic mice 1017
Hashimoto, C . Gerttula. S. and Anderson. K. V.Plasma membrane localization of the Toll protein in thesyncytial Drosophila embryo: importance of transmembranesignaling for dorsal-ventral pattern formation 1021
Peifer. M.. Rauskolb. C. Williams, M., Riggleman. B. tand Wieschaus, E. *• • .The segment polarity gene armadillo interacts with the M iL^awingless signaling pathway in both embryonic and adultpattern formation 1029
Christian. J. L.. McMahon. J. A.. McMahon, A. P. H — + - • •and Moon. R. T.Xwnt-8. a Xenopus WntA /nM-related gene responsive tomesoderm-inducing growth factors, may play a role in ventralmesodermal patterning during embryogenesis 1045
Harvey, M. B. and Kaye, P. L. .j "^IGF-2 receptors are first expressed at the 2-cell stage ofmouse development 1057
Hardy, R. and Reynolds, R.Proliferation and differentiation potential of rat forebrainoligodendroglial progenitors both in vitro and in vivo 1061
Glick, A. B.. McCune, B. K.. Abdulkarem. N.. • , j _.iFlanders. K. C, Lumadue. J. A.. Smith, J. M. *"and Sporn, M. B.Complex regulation of TGF /; expression by retinoic acid inthe vitamin A-deficient rat i ' " " '
Huang, F.. Dambly-Chaudiere. C. and Ghysen, A. '-.The emergence of sense organs in the wing disc of "•Drosophila , ^
Ott, M.O.. Bober, E.. Lyons, G., Arnold, H.and Buckingham, M. *•Early expression of the myogenic regulatory gene, myf-5. inprecursor cells of skeletal muscle in the mouse embryo 1097
Pravtcheva, D. D., Adra, C. N. and Ruddle, F. H.Timing of paternal Pgk-1 expression in embryos of transgenic
Parkhurst, S. M. and Ish-Horowicz, O.Mis-regulating segmentation gene expression in Drosophila 1121
Hunt, P. A.Survival of XO mouse fetuses: effect of parental origin of theX chromosome or uterine environment? 1137
Schniirch, H. and Risau, W.Differentiating and mature neurons express the acidicfibroblast growth factor gene during chick neural development 1143
Jones, R.Interaction of zona pellucida glycoproteins. sulphated d^flccarbohydrates and synthetic polymers with proacrosin. theputative egg-binding protein from mammalian spermatozoa 1155
Urch, U. A. and Patel, H.The interaction of boar sperm proacrosin with its naturalsubstrate, the zona pellucida. and with polysulfatedpolysaccharides 1165
Weeks, D. L. Walder. J. A. and Dagle. J. M. • l J
Cyclin B mRNA depletion only transiently inhibits the Xenopusembryonic cell cycle 1173
Su, M.-W., Suzuki. H. R.. Solursh, M. and Ramirez. F. " - —Progressively restricted expression of a new homeobox-containing gene during Xenopus laevis embryogenesis 1179
Index of Authors and Titles
Subject Index
•< : !
