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Alexandra Schratter; Holger Thiele; Katharina Demmin; Denise Lehmann; Meinhard Mende; Gerhard 

Schuler; Thorsten Klemm; Undine Pittl 

Univ Leipzig, Leipzig, Germany; Cntr for Clinical Studies, Leipzig, Germany; Univ Leipzig, Leipzig,

Germany; Laboratory Reising-Ackermann, Leipzig,

Germany; Univ Leipzig, Leipzig, Germany 

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Purpose: NSE (neuron specific enolase) is a well-known

blood parameter for quantifying neuronal damage andtherefore predicting neurologic outcome after cardiac

arrest. However, recent studies showed discrepant results

regarding specific time-points of blood sample acquisition

and cut-off values of NSE in order to obtain optimalpredictive power. We conducted this study by collecting 

blood samples from patients undergoing therapeutic

hypothermia after cardiac arrest in order to define new 

cut-off values of NSE as well as the time-point of its most predictive power regarding good neurologic outcome.

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Methods: Blood samples were collected from patients

undergoing therapeutic hypothermia after cardiac arrest 

either by invasive or external cooling at 7 pre-definedtime-points (0, 6, 12, 24, 36, 48 and 72 hours) before and

after the onset of hypothermic treatment. One hundred-

and-nine patients were included in the study. Neurologic

outcome was assessed at hospital discharge (cerebralperformance category, CPC). ROC-curves of NSE values

 were drawn for all time-points in order to determine cut-

off values for good neurologic outcome (CPC 1 and 2).

Cut-off values of NSE at each time-point were determinedby taking the value with the highest sensitivity still showing 

100% specificity.

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Results: Area under the curve of all ROC-curvesincreased from time-point to time-point and reached its

maximum at 72 hours, which indicates best predictive

power regarding good neurologicoutcome. Our

determined NSE cut-off values were 42.5, 41.0, 43.5,35.5, 36.5, 46.5 and 29.0 ng/mL for time-points 0, 6, 12,

24, 36, 48 and 72 hours, respectively. Patients with good

neurologic outcome all showed a NSE value below the

determinedcut-off for every time-point.

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Conclusions: Neuron specific enolase is a well-known

predictor for neurologic outcome after cardiac arrest and

cardiopulmonary resuscitation. By including a large

number of patients, we could determine a new reliable

NSE cut-off value. NSE < 29 ng/mL at 72 hours after the

onset of therapeutic hypothermia has the strongest 

predictive power for good neurologic outcome.

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 Author Disclosures: A. Schratter: None. H. Thiele:None. K. Demmin: None. D. Lehmann: None.M.

Mende: None. G. Schuler: None. T. Klemm: None. U.

Pittl: None.

http://circ.ahajournals.org/cgi/content/meeting_abstract/1

22/21_MeetingAbstracts/A129?maxtoshow=&hits=10&R 

ESULTFOR M AT=&fulltext=neurologic+researches&sear

chid=1&FIRSTINDEX=0&resourcetype=HWCIT

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REACTION:This study was conducted to determine at

what specific period we can predict the most

accurate neurologic outcome after a cardiac

arrest and undergoing hypothermic treatment.They have found out that a new reliable NSE cut-

off value is <29ng/mL at 72 hours after onset of 

therapy has the strongeast predictive power for

good neurologic outcome.

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This finding is very helpful because it

improves the use of NSE as a parameter and

also treatment among these patients.And also, it may increase survival rate among 

cardiac arrest if this new finding could lessen

cardiac arrest episodes among patients risk for

cardiac arrest.

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SUBMITTED BY:

GUINODEN, REX DAVE T.AYOCHOK, CLIFTON.

BCU-SNIII

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More elaboration about the journal is

needed

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