503ROYAL ACADEMY OF MEDICINE IN IRELAND.
Mrs. WARREN spoke of her work in Uganda, andimplied that there was room for more women, butthat up to the present the prospect had not seemedalluring, and practically none had applied. Govern-ment work was essential, as private practice does notyet exist, the British population being relativelyvery small.
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NORTH OF ENGLAND OBSTETRICAL ANDGYNECOLOGICAL SOCIETY.
A MEETING of this Society was held at Sheffield onFeb. 22nd, with Dr. G. W. FITZGERALD, the President(Manchester), in the chair.
Specimens and Cases.Prof. CARLTON OLDFIELD (Leeds) showed a specimen
of some foetal bones and a uterus removed postmortem. The foetal bones had caused intestinalobstruction.
Mr. N. L. EDWARDS (Derby) described a case ofuterine fistula following Csesarean section.The patient, aged 25, had had a Csesarean section per-
formed for obstructed labour in 1923. The convalescencefrom this was uneventful, no rise of temperature beingrecorded. A year later the upper end of the wound brokedown, discharging a small quantity of pus. The sinuspersisted and after May, 1928, menstrual fluid escaped fromit at the menstrual periods which were regular. In September,1928, the fistulous track was excised entire together with awedge of the anterior uterine wall in which were embeddedtwo thick silk sutures. Sections of the fistulous track showno evidence of endemetrioma.
Mr. Edwards said that the case illustrated thedangers of unabsorbable sutures in the uterine wall.Other members expressed the opinion that it was themethod of suture rather than the material usedwhich mattered in ensuring a well-healed uterine scar.
Prof. CARLTON OLDFIELD recounted two cases ofruptured malignant ovarian cysts. Both cases wereseen as acute abdominal emergencies. When theabdomen was opened it was found full of " boiledsago "-like material which was mopped out and theruptured cyst removed. In each case the abdomenwas reopened later and the rest of the generative organswere removed. Both patients had had prophylacticdeep X rays since operation. One patient remainedwell for three and a half years, after which shedeveloped symptoms suggesting a recurrence. Theother patient had a recurrence a year later in thetransverse colon ; 15 months after this one in thejejunum; and now, another 15 months later, hadone in the roof of the vagina involving the bladder.
Prof. Oldfield invited discussion on the use ofprophylactic deep X rays and on prognosis in malignantovarian neoplasms. Several members expressed theopinion that deep X rays were not without danger andthat the prognosis in these cases was not as bad aswas usually thought.
Prof. W. FLETCHER SHAW (Manchester) read notesof a case of uterine diverticulum from a patientaged 34, eight years married and sterile.
She complained of recurrent severe pain in the left iliacfossa at the menstrual period. Examination revealed amass the size of a small orange in the region of the leftappendage. At operation this mass was found to be acystic left ovary and in the left broad ligament a hardtumour of regular outline about 1 in. long and 1 in. wide ;its upper border was about in. below the round ligamentand Fallopian tube and in no way connected with either.It was enucleated from the broad ligament by a considerableamount of blunt dissection and the pole nearest to theuterus actually had to be cut out with scissors. Sectionsshow the tumour to have a thick outer muscular coat andto contain a cavity lined with endometrium but with noretained blood. Its relationship to and entire separationfrom the round ligament and Fallopian tube preclude itfrom being considered as a poorly developed uterine horn.
Prof. Fletcher Shaw thought it was a diverticulumbudded out from the uterine cavity and then shut offtherefrom.
Miss FRANCES IVENS (Liverpool) recorded a case of
puerperal gas gangrene infection, a report of whichwill be published in our columns.
Dr. J. W. A. HUNTER (Manchester) read a note on
Hysterotomy.He pointed out that the term was used both for anincision into the uterine body through an abdominalincision and for incision of the cervix per vaginam.He suggested that the word
’’ trachelotomy " be used
for the latter operation and used it throughout hisnote. Trachelotomy could be used to facilitate theemptying of the gravid uterus either during pregnancyor at full term, when it was usually done during labour.The note dealt with the use of the operation in labourand the cases of failure of the cervix to dilate weredivided into two classes : (a) those in which thecervix was normal; and (b) those in which the cervixwas abnormal either in size or consistency. Themechanism of normal cervical dilatation was describedand failure of this was noted as often due to prematurerupture of the membranes associated with slightdisproportion between foetal head and maternalpelvis. The note dealt with cases where the cervixwas abnormal in length or structure (congenitally), orwhere it was a part of prolapse and the cervix washard, thick, and fibrous, but not appreciably elongated.The last type was seen in elderly primigravidee or inmultigravidae as the result of scar tissue formation.The cases might be complicated by premature ruptureof the membranes, slight extension of the head oroccipito-posterior positions. The patients were
usually left for a considerable time to give the cervixa chance of dilating, but eventually their pulse andtemperature began to rise. There was often a historyof considerable interference and the child might bedead. Recognised methods of delivery had theirdifficulties and disadvantages. Trachelotomy allowedof clean incisions into the cervix which could bestitched up carefully immediately afterwards andwould allow of delivery by forceps or craniotomy.The method described was of one or two postero-lateral incisions from external to internal os, behindthe middle line to avoid the cervical branches of theuterine artery. This length of incision prevented itextending further during delivery. If two incisionswere decided upon it was important to mark the siteof the second before making the first, as after the firstmuch retraction occurs and orientation is difficult.Accuracy of apposition in suture of the incisions wasinsisted upon.
ROYAL ACADEMY OF MEDICINE INIRELAND.
SECTION OF MEDICINE.AT a meeting of this Section on Feb. 15th, with
Prof. R. J. RowLETTB, the President, in the chair,a paper on
Protein Shoc7, Therapywas read by Dr. V. M. SYNGE. His cases were treated,he said, with two intravenous injections of TABvaccine, the first containing 100 million B. typhosusand 50 million each of paratyphoid A and B, whilstthe second, given after 5 to 7 days, contained doublethe number of organisms. About an hour afterinjection a rigor occurred with a sharp rise in tempera-ture to 103° or 104° F. There was severe headache,pains and sweating, and sometimes vomiting anddiarrhoea. Aspirin and perhaps morphia were givento relieve the pains. In cases which did well thetemperature was always normal within 24 hours ;if the temperature remained up for 48 or 72 hoursthere was never any improvement as a result of thetreatment. Twelve cases (chronic sciatica, chronicarthritis, persistent muscular rheumatism) were
treated. In most there was slight temporary benefit,in some no improvement, and in a few cases per-manent cure. Two illustrative cases were:-
1. Man, aged 49, right-sided sciatica for nine years ;tenderness along course of nerve, wasting of right thigh ;
504 REVIEWS AND NOTICES OF BOOKS.
hip-joint normal. Unable to work for nine months. Aftertreatment pain disappeared and he resumed work. Whenlast heard of 14 months after treatment he was still freefrom pain.
2. Man, aged 25, left-sided sciatica for four months.After first injection, rigor and high temperature, temperaturenot normal for 48 hours. After second injection, rigor andhigh temperature, temperature not normal for 72 hours.No improvement from the treatment.
The method, said Dr. Synge, was not new, and wasoften unsuccessful, but deserved wider use in chronicsciatica and rheumatic conditions where ordinarymethods had failed. Obviously it should not beemployed for feeble patients or those with cardiacdisease.The PRESIDENT had never understood why vaccines
were the form of protein most commonly employed ;a vaccine of TAB, besides its protein content,must contain a certain amount of toxin, and so acertain amount of toxaemia must be produced, a
complication which would be avoided by usingproteins which contained no toxin.
Dr. PRESTON BALL had treated 15 cases accordingto the method advocated by Yeoman of Harrogate,land had got very good results. The objection wasthat the immediate reaction was extraordinarilyalarming. He had found the treatment successfulwhere there was profuse sweating immediately afterthe injection, and where the temperature had comedown rapidly. He thought that in the unsuccessfulcase mentioned by Dr. Synge the result might havebeen good if more injections had been given. Theroutine treatment was at least five injections.
Dr. E. T. FREEMAN said he had first used the treat-ment for cases of chronic urticaria and similar con-ditions. He had at first used peptone, but now usedTAB vaccine. This produced a very rapid effectin a very short time.He mentioned a case of mucous colitis to whom he had
given about twenty injections, and the motions haddecreased from 20 a day to 3 a day. The patient had remainedwell for some months, but then returned to hospital andwas given an enema which had started the colitis again,and on this occasion the treatment had not been successful,and caecostomy had been performed.In cases of bony involvement he had found thatprotein shock sometimes alleviated pain, but theresults were never permanent. He thought the greatobjection to the method as a routine was that it wasutterly impossible to foretell the result. It was anunpleasant treatment, but if it were possible to knowthe kind of case that would respond, it might be usedmore often and with greater assurance.
Dr. G. E. NESBITT said the method seemed to belargely on the lines of malarial therapy of para-syphilitic infections, which he did not think wouldsucceed as a permanent mode of treatment. Heasked if Dr. Synge had made any observations on thewhite cell content in his cases.-Dr. W. G. HARVEYpreferred the term " non-specific therapy " to
" proteinshock therapy." Dr. A. B. CLERY mentioned a casein which pain in the legs cleared up after an injectionof TAB.
Dr. SYNGE, in reply, said that he preferred TABvaccine to other forms of protein because it wasstandardised, and therefore it was easy to decideon the amount which should be given at each injection.He had not investigated the white cell count in hiscases. The treatment was unpleasant, and manypatients after one injection refused to have a second ;but if improvement did not follow the first, or at anyrate the second injection, he thought it meant thetreatment was not going to be successful. Themethod was harmless, and the cures amounted to20 or 25 per cent., which he thought made it worthyof trial.
Dr. R. E. STEEN read a paper on Congenital PyloricStenosis, and Dr. J. H. POLLOCK contributed noteson a case of Hysteria.
1 See THE LANCET, 1926, i., 1246.
Reviews and Notices of Books.INFANTILE DEFORMITIES.
Diagnosis and Treatment of Deformities in Infancyand Early Childhood. By M. F. FORRESTER-BROWN,M.S., M.D. Lond., Surgeon, Bath, Somerset, andWilts Central Children’s Orthopaedic Hospital.With a Foreword by Sir ROBERT JoNES, Bart.,K.B.E., C.B., F.R.C.S. London : HumphreyMilford, Oxford University Press. 1929. Pp. 199.14s.As Sir Robert Jones states in his foreword, this book
is a lucid exposition of orthopaedic principles, writtenby a surgeon with wide knowledge. It is especiallyintended for the school doctor, the general practitioner,and all those interested in infant welfare work. Theauthor’s work during the war in the treatment andhistory of nerve injuries is well known, and since thearmistice she has made herself equally accomplishedin orthopaedic work for which she has ample scope atthe orthopaedic hospital at Combe Down, near Bath,and at the clinics in the counties of which it is thesurgical centre. The book differs from other mono-graphs on orthopaedic subjects in that it is writtenin simple language with the single aim of makinggeneral practitioners and those in charge of ortho-peadic clinics thoroughly conversant with the earlysigns and symptoms of deforming disease, and by theearly application of suitable treatment to preventthe obvious and crippling effects of untreated lesions.Every orthopaedic surgeon is familiar with cases of,say, congenital dislocation of the hip and knows howlong and tedious is their treatment if a good resultis to be obtained. Such cases are, however, rarelydetected till some time after the child has begun towalk, when changes have occurred which renderdifficult any anatomical rehabilitation. Yet if thedefect of the acetabulum were recognised in the firstfew months of life cure would in many cases be easy.The specialist has little chance of seeing such patientsearly, and it is on the general practitioner that theonus of early diagnosis is thrown, more especiallysince the blame of this developmental defect is apt tobe imputed to him in his obstetric capacity.We commend those parts of the book which deal
with defects of posture to our readers, for here theauthor speaks with authority, having worked underProf. J. E. Goldthwait, of Boston, and having achievednotable results in her own clinic at Bath. The hintsgiven as to the application of plaster-of-Paris are
the valuable outcome of actual experience of diffi-culties and of the ways of surmounting them. Instru-ments are sufficiently described and the principleswhich should guide their prescription clearly stated.The book is well illustrated.
COLLECTED SCIENTIFIC PAPERS OF JOHN JAMESWATERSTON.Edited with a biography by J. S. HALDANB,M.D., LL.D., F.R.S., Fellow of New College,Oxford. London: Oliver and Boyd. 1928.Pp. 709. 25s.THE prompt recognition of true merit is one of the
greatest difficulties in all administrative work. Whileit is generally believed that this difficulty is lessserious in science than in other branches of work, suchas literature or art, in which recognition is almost ascommon post mortem as ante mortem, there are
exceptions to this rule. The case of John JamesWaterston is one of the most striking of these. Thisscientist carried out much original work of first-classimportance, and was, as his biographer says, wellahead of his time in the subjects which he studied.Yet his most important paper-on what is now calledthe kinetic theory of gases-was refused publicationby the Royal Society and lay unrecognised for46 years until Lord Rayleigh disinterred it in 1891.It is somewhat disquieting to read this paper and tosee that what is now regarded as an elementary and