From the Director:

I am particularly pleased to invite you to our 6th AnnualUniversity of California Neurotrauma Symposium. Thisyear's program was assembled with the help ofDr. Fernando Gómez-Pinilla at UCLA. Through his efforts,the program features topics related to the immune andendocrine systems, neural plasticity as it relates to neuro-rehabilitation, issues related to neuroengineering, and stemcell neurobiology. As is customary, we will continue tofeature lectures on cerebral metabolism and the effects oftraumatic brain injury when it occurs early in life. A newfeature introduced this year will be a “Hot Topics” sessionthat will allow investigators to present their most excitingscience in a brief, yet interactive, environment.

Along with the Young Investigator presentations, I amsure you will find the program to be scientifically stimulatingand socially enjoyable. Special thanks go out to the BrainInjury Association of America and the law offices ofGoldberg and Gille for their financial support of this year'smeeting.

On behalf of the UCLA Brain Injury Research Centerand the University of California Neurotrauma AdvisoryBoard, I hope that you will enjoy the facilities at the OjaiValley Inn & Spa as well as the exciting science presentedduring the meeting.

David A. Hovda, Ph.D.Director, UCLA Brain Injury Research Center

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register by contacting:Kathryn E. Rasco(310) 206-0588

krasco@mednet.ucla.edu

12:00 Registration and Welcome Reception

1:00 Opening Remarks - David A. Hovda, PhD (UCLA)

DOES AGE MATTER FOR A BETTER BRAIN?Christopher C. Giza, MD & Mayumi L. Prins, PhD (UCLA) Co-chairs

1:20 Age at Injury Considerations in Pediatric Traumatic Brain InjuryP. David Adelson, MD (Univ. of Pittsburgh)

1:50 Traumatic Injury and Antioxidant Status as Modulators of Neurogenesis inthe Immature Brain

Matthew B. Potts, BS (UCSF)

2:10 Age and Cerebral Metabolic Adaptation Following TBIMayumi L. Prins, PhD (UCLA)

EMERGING NEURO-ENGINEER APPROACHES FOR TBIPaul M. Vespa, MD (UCLA) Chair

2:30 Upcoming Technology for Brain Monitoring and StimulationJack W. Judy, PhD (UCLA)

2:50 Selecting the Signals for a Brain-Machine InterfaceRichard A. Andersen, PhD (Caltech)

3:10 Break

YOUNG INVESTIGATORS

3:30 Neuropsychological and Functional Recovery after TBI in ChildrenFabienne Cazalis, PhD (UCLA)

3:45 Traumatic Brain Injury, Enriched Environment, and N-Methyl-D-AspartateReceptor-Mediated Neuroplasticity in the Immature Rat

Naomi Santa Maria, BS (UCLA)

4:00 Update of Voltage-Gated Ca++ Channels and TBIKiarash Shahlaie, MD (Resident & PhD student, UCD)

4:15 Exercise-Induced Cognitive EnhancementShoshanna Vaynman, PhD (UCLA)

4:30 Cybernetic Control of Brain MetabolismAlejandro Covalin Sharfman (Neuro-engineer grad student, UCLA)

5:00 "Hot Off the Press" 5 Minutes / 1 Slide - Open to Everyone (10-15 Spots)Fernando Gómez-Pinilla, PhD (UCLA) Chair

6:30 Reception

7:00 DinnerBrain Injury Association of America Young Investigator AwardSpeaker: Yoichi Katayama, MD, PhD (Nihon Univ., Tokyo)

7:15 Continental Breakfast

PLASTICITY AND NEURAL REPAIR - REORGANIZATIONOF CORTICAL MAPS RELATED TO EXPERIENCE

Timothy Schallert, PhD (Univ. of Texas) Chair

8:00 Training-Induced Cortical Plasticity Jeffrey Kleim, PhD (UCI)

8:20 Experience Transforms Cortical Sensory Maps Ron D. Frostig, PhD (UCI)

8:40 Lesion Effects on Functional Plasticity Timothy Schallert, PhD (Univ. of Texas)

9:00 Break

REHABILITATIVE STRATEGIES FOR TBIMark J. Ashley, ScD, CCC-SLP, CCM (Centre for Neuro Skills, Bakersfield), Chair

9:20 Acute Rehabilitation Alan H. Weintraub, MD (Craig Hospital, Englewood, CO)

9:40 Post-Acute Rehabilitation Richard Helvie, MD (Centre for Neuro Skills)

10:00 Sensory and Motor Rehabilitation in Animals and Humans Nancy Byl, PhD (UCSF)

10:20 Panel DiscussionV. Reggie Edgerton, PhD (UCLA) & J. Paul Muizelaar, MD, PhD (UCD) Co-chairs

10:40 Break

IMMUNE AND ENDOCRINE INVOLVEMENT IN TBIDaniel F. Kelly, MD (UCLA) Chair

11:00 Pathophysiology of Endocrine Involvement in TBI Daniel F. Kelly, MD (UCLA)

11:20 Unveiling the Inflammatory Response in TBI Linda J. Noble-Hauesslein, PhD (UCSF)

IMAGING FUNCTIONAL RECOVERYSteven C. Cramer, MD (UCI) Chair

11:40 Functional Imaging in Recovery Steven C. Cramer, MD (UCI)

12:00 Synaptic Activity and Hemodynamics of the Cerebral CortexArthur W. Toga, PhD (UCLA)

12:20 Diffusion Tensor MR Imaging for Tracing Fibers in TBIPratik Mukherjee MD, PhD (UCSF)

12:40 Lunch

1:15 Breakout Activity Session for Families with ChildrenMayumi L. Prins, PhD & Christopher C. Giza, MD (UCLA)

Afternoon Free Time

7:00 Dinner - The Big Red Barn

7:15 Continental Breakfast

NIH - THE GOOD, THE BAD AND THE UGLYDavid A. Hovda, PhD (UCLA) - Chair

8:00 TBI Research: NIH Support and PerspectivesJoseph J. Pancrazio, PhD (NINDS)

FROM ENERGY METABOLISM TO FUNCTIONAL RECOVERYDavid A. Hovda, PhD (UCLA) - Chair

8:20 Cerebral Metabolism and TBIDavid A. Hovda, PhD (UCLA)

8:30 Lactate ShuttlesGeorge A. Brooks, PhD (UCB)

8:50 A Vintner's Perspective on Mitochondrial Function in TBIGary Fiskum, PhD (Univ. of Maryland)

9:10 Coupling Energy Metabolism with Synaptic PlasticityFernando Gómez-Pinilla, PhD (UCLA)

9:30 Break

AN INTRODUCTION TO NEURAL STEM CELLHarley I. Kornblum, MD, PhD (UCLA) Chair

9:50 An Introduction to Neural Stem CellHarley I. Kornblum, MD, PhD (UCLA)

10:10 Postnatal Profiling of Neural Stem Cell ActivationSteven G. Kernie, MD (Univ. of Texas Southwestern Medical Center)

10:30 Neural Repair ApplicationsEvan Y. Snyder, MD, PhD (Burnham Institute, La Jolla)

10:50 Adapting Neuronal Phenotype for ImplantationJean S. De Vellis, PhD (UCLA)

11:10 Panel DiscussionNeil A. Martin, MD (UCLA) & Evan Y. Snyder, MD, PhD (Burnham Institute)

11:30 Wrap upDavid A. Hovda, PhD (UCLA)

11:45 Adjourn

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August 10 - 12, 2005Ojai Valley Inn & Spa • Ojai, California

6th Annual

University of CaliforniaNeurotrauma Meeting

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