Sambasivarao Kotha, Enugurthi Brahmachary and Kakali Lahiri
Department of Chemistry
Eur. J. Org. Chem. 2005, 4741–4767 (215 citations)
2
Our research topics
-Amino AcidsAcc. Chem. Res. 2003, 342
Synlett. 2010, 337
Suzuki-Metathesis
Chem. Asian J. 2009, 354
MetathesisIndian J. Chem. 2001,763
Synlett 2007, 2767
Chem. Soc. Rev. 2009, 2065
Org. Biomol. Chem. 2011, 5597
Suzuki CouplingTetrahedron 2002, 58, 9633
Eur. J. Org. Chem. 2007, 1221
PolycyclicsTetrahedron 2001, 57, 625
Tetrahedron 2008, 64, 10775
Synthesis 2009, 165
Peptide Modifications
Curr. Med. Chem. 2005, 12, 849
[2+2+2] CycloadditionEur. J. Org. Chem. 2005, 4741
Chem. Rev 2011, 000Rongalite
TROUBLESHOOTING
PRODUCT
EXECUTION(TECHNIQUE)
STRATEGY(REACTIONS)
DESIGNOPTIONS(CONNECTIVITY)
PRIORITIES &CONSTRAINTS
SYNTHESIS STAR
IDEALLY......PRIORITIES & CONSTRAINTS
TROUBLE-SHOOTING
• Readily available starating materials
• One step
• 100% yield
• Operationally simple
• Fast, Safe
• Environmentally acceptable
• Resource efficacious
Change in
• Conditions
• Mechanism
• Reactants
• Strategy
• Personnel
1. Organic Synthesis
Solvent free
Conditions
Aqueous
ConditionsIonic Liquid
Conditions
Supercritical
Conditions
2. Synthetic Efficiency
Tandem
Process
Multicomponent
Reactions
Multidirectional
Synthesis
3. Synthetic Methodology
Generation of molecular
Diversity
Suitable for Combinatorial
Synthesis
4. Catalytic Processes
Asymmetric synthesis
Using small molecules
Environmentally Friendly
Processes
Salt Free Processes
5. Organometallics in Organic Synthesis
59/9/2011
ORGANIC SYNTHESIS
Target Oriented
(Total Synthesis)Methods Oriented
Natural
Products
Designed
MoleculesReagents Catalysts Synthetic
Strategies
Synthetic
Tactics
Material Science
Interesting
Molecules
Biologically
Interesting
Molecules
Theoretically
Interesting
Molecules
Medically
Interesting
Molecules
Nicolaou, K. C.; Sorensen, E. J. Classics in Total Synthesis, VCH, Weinheim, Germany, 1996.
Amongst the top ten most downloaded articles in
Eur. J. Org. Chem.: November 2005
[2+2+2] cycloaddition reaction
Eur. J. Org. Chem. Among most cited article during 2005-2006
Applications of Amino Acids
Amino Acids
Pharmaceuticals
Pharmaceutical
Intermediates
Food
Additives
Feed
Additives
Technical
Applications Media for
Fermentation
and Cell Culture
Peptides
Taste and
Aroma
Enhancers
Cosmetics
Pesticides
The Building Block approach to unusual -Amino Acid
derivatives and Peptides
S. Kotha Acc. Chem. Res. 2003, 36, 342.
List of constrained Phe analogues (the thick line indicate Phe moiety)
NH2
CO2H
NH2
CO2H
NH2
CO2HCO2H
NH2 NH
CO2H
CO2H
NH2
NTs
E
NTs
E
OAc
NHAc
EtO2C
NHAc
CO2Et
NHAc
CO2Et
NHAc
CO2Et
NHAc
CO2Et
X
NHR
CO2Et
NHAc
CO2Et
NHAc
CO2Et
I
I
NTs
E
NTs
E
AAA Building Blocks
A B C D E F G FinalTarget
A B C D
W X Y Z
Final Target
Linear and convergent synthetic approaches
A B C D BB
Final Target (T1)
Final Target (T2)
Final Target (T3)
Synthetic strategy involving building block (BB) approach
Ethyl isocyanoacetate as a glycine equivalent
EtO2C NC
NH2
CO2Et
N
NNH2
CO2Et
NHAc
CO2Et
NHAcEtO2C
NHAc
CO2Et
AcHNCO2Et
EtO2C NHAc
OOCO2Et
NHAc
CO2Et
NHAc
NHBoc
CO2Et
R
R
NHAc
CO2Et
O
O
O
NHCOtBu
CO2Et
NHAc
CO2Et
NHAc
CO2Et
NHAc
CO2Et
CO2Et
NHAc
EtO2C
AcHN
NHAc
CO2Et
Kotha, S. Halder, S. Synlett 2010, 337
[2+2+2] Cycloadditions
Rh(PPh3)3Cl CpCo(CO)2
Wilkinson’s catalyst Vollhardt catalyst
O
O
NHAc
CO2Et
N
C
OE = CO2Et
NTS
E
N
R1
R2
R3
R4
+CO2Et
Ts
NTs
CO2Et
R1
R4
R3
R2
Rh(PPh3)3Cl
Kotha, S.; Sreenivasachary, N. Eur. J. Org. Chem. 2001, 18, 3375.
CO2Et
NHAc
R
R
+Rh(PPh3)3Cl
CO2Et
NHAcR
R
Kotha, S.; Brahmachary, E. Tetrahedron Lett. 1997, 38, 3561.
NHBoc
O
XxxOMe
OH
OH
Rh(PPh3)3Cl NHBoc
OH
OH
O
XxxOMe
+
Kotha, S.; Mohanraja, K.; Durani, S. Chem. commun. 2000, 1909.
O
O R
R
+Rh(PPh3)3Cl
O
O
R
R
Kotha, S.; Manivannan, E. J. Chem. Soc., Perkin Trans. 1 2001, 2543.
NC
CO2Et
1. Propragyl bromide,K2CO3, CH3CN,
TBAHSNHAc
CO2Et
(Ph3P)3RhCl
2-butyn-1,4-diol2. HCl, EtOH, RT CO2Et
NHAc
OH
OH3. Ac2O, DCM, RT
A new entry to indane-based amino acid derivatives
Kotha, S.; Ghosh, A. K. Tetrahedron 2004, 60, 10833.
Kotha, S.; Ghosh, A. K. Tetrahedron Lett. 2004, 45, 2931.
CO2Et
NHAc
Br
Br
CO2Et
NHAc
CO2Et
NHAcS
O
O
a
c, d
Reaction conditions: a) PBr3, DCM, rt, b)Rongalite, Bu4NBr,
DMF, 0 oC, 72%, c) DMAD, toluene, 120 oC, d) DDQ, benzene,
80 oC, 78%
CO2Et
NHAcMeO2C
MeO2C
OH
OH
CO2Et
NHAc
b
Preparation of benzoannulated indane-based amino acid derivatives
Rongalite
HO SO2Na.2H2O
Sodium hydroxymethanesulfinate or
Sodium formaldehydesulfoxylate
Decolorizing agent in textile industry
Inexpensive, commercially available
Benzoannulated indane-based amino acid derivatives
CO2Et
NHAc
CO2Et
NHAc
CO2Et
NHAc
O
O
CO2Et
NHAc
O
O
CO2Et
NHAc
O
O
78% 43%
90%
89%
92%
MeO2C
MeO2C
MeO2C
Various AAA building blocks failed to react with C60
CO2Et
NHAcAcHN
EtO2C
+ C60
NiCl2(PPh3))2
Zn, PPh3
Toluene, 120oC
X
AcHN
EtO2C
C60
Toluene, 120oCX+
CO2Et
NHAc
Br
Br
C60
PTC
X+
AcHN
EtO2C CO2Et
NHAc
Sultine undergoes DA reaction with C60:
Entry to fullerene based amino acids
C60Toluene, 120oCS
O
O
CO2Et
NHAc
CO2Et
NHAc
CO2Et
NHAcEtO2C
AcHN
49%
12%
+
Entry to polysubstituted benzene derivative
CO2Me
CO2Me
Rh(PPh3)3Cl
CO2MeMeO2C
MeO2C
MeO2C
MeO2C
MeO2C
CO2Me
CO2Me
CO2Me
CO2Me
+Ethanol, Reflux
+
Kotha, S.; Khedkar, P. Eur. J. Org. Chem. 2009, 730.
CO2Me
CO2MeCO2Me
CO2Me
Rh(PPh3)3Cl
+
Ethanol, Reflux
Expected
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
DiynePolysubstituted benzene
derivative obtainedYield (%)
37
22
52
60
Wilkinson’s catalyst: Bringing two DMAD and
one diyne molecule together
Ruthenium catalyst: Bringing two DMAD and
one diyne molecule together
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
CO2MeMeO2C
MeO2C
MeO2C
DiynePolysubstituted benzene
derivative obtainedYield (%)
32
25
42
37
Two competing o-quinodimethane precursors built in a one molecule.
The difference in their reactivity may be exploited towards the synthesis of unsymmetrical polycyclic compounds.
(a) Kotha, S.; Khedkar, P. J. Org. Chem. 2009, 74, 5667.
(b) Kotha, S.; Chavan, A. S. J. Org. Chem. 2010, 75, 4319.
Two o-quinodimethane precursors of Differential
Reactivity!!!
Rongalite: Providing a simple access to novel BCB derivative
containing sultine moiety in its molecular frameworkb
(a) Hillard, R. L.; Volhardt, K. P. C. J. Am. Chem. Soc. 1977, 89, 4058.
(b) Kotha, S.; Khedkar, P. J. Org. Chem. 2009, 74, 5667 .
Preparation of diester and diol derivatives
OH
OH
Diyne Cyclotrimerised product
(benzocycloalkane diester)Yield
(%)Yield
(%)
Benzocycloalkane diol
obtained
CO2Me
CO2Me
CO2Me
CO2Me
OH
OH
CO2Me
CO2Me
OH
OH
CO2Me
CO2Me
OH
OH
37
13
34
20
86
50
49
52
Preparation of dibromo and sultine deivatives
HO
HO
Benzocycloalkane
dibromide
Yield
(%)
a) The dibromides are prepared under NaBr-BF3.OEt2/acetonitrile conditions.
b) The reagent used for these conversions is PBr3.
Yield
(%)
HO
HO
HO
HO
HO
HO
Br
Br
Br
Br
Br
Br
Br
Br
Benzocycloalkane
diol
Benzocycloalkane
sultine
O
S
O
S
O
S
O
O
O
55a
90b
98b
94b
75
79
70
66
S
O
O
Preparation of Diels-Alder adducts
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
O
S
O
O
S
O
O
S
O
O
S
O
SO2
SO2
SO2
SO2
Yield (%)
a) The conversion is acheived by heating sultine at 100 oC in toluene.
b) The conversion is effected by using microwave irradiations (power:100%,
time: has to be standardized, solvent: o-dichlorobenzene).
DA adductYield (%)
Sultine derivative
Sulfone derivative
40a
21b
33b
33b
52
38
57
44
Aromatization of DA adducts using with MnO2
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
DA adduct Yield
(%)Aromatized product
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
CO2Me
99
96
98
98
H2N CO2Me CO2Et
NHAc
CO2Et
NHCHO
Br
Br
CO2Me
CO2Me
CO2Me
CO2Me
OH
OH
[2+2+2]
reactionLAH
BF3.Et2O
HCHO/HBr NBSHCHO/HBr
Brx x
NaBr
Br
Br
CO2Me
CO2Me
CO2Me
CO2Me
OH
OH
[2+2+2]
reactionreduction
bromination
HCHO/HBr
Br
Br
CO2Et
NCCO2Et
NH2
CO2Et
NHAc(i) (ii) (iii)
n = 1 5an = 2 5bn = 3 5cn = 4 5d
n n n n
NC
CO2Et
n = 1 7an = 2 7bn = 3 7cn = 4 7d
n = 1 3an = 2 3bn = 3 3cn = 4 3d
Reagent and condition: (i) EICA, K2CO3, TBAHS, CH3CN, 12 h, reflux; (ii) ethanol, dil. HCl, RT, 12 h;
(iii) Ac2O, DMAP, DCM, RT, 10 h
Kotha, S. Krishna, N. G. Misra, S. Khedkar, P. Synthesis 2011 (DOI: 10.1055/s-0030-1260145)
List of various benzocycloalkane AAAs prepared
Entry Substrate Product Yield (%)a
Br
Br
NHAc
CO2Et
Br
Br
NHAc
CO2Et
42
35
Br
Br
Br
Br
NHAc
CO2Et
25
36
1
2
3
4
NHAc
CO2Et
34
Synthesis of Dialkenyl Based Peptides
EtOOC
CN
EtOOC
CN
2
a
1
b EtOOC
H2N
3
EtOOC
RHN
HOOC
RHN
c
de
RHN
HN
O
COOMe
5 (R=Boc)6 (R=Boc)
H
95% 94%
4 (R=Boc) 82%
Reagents and conditions: (a) Propargyl bromide, K2CO3, TBAHS, CH3CN, reflux, 16 h; (b) EtOH/HCl, rt, 2
h; (c) (Boc)2O, CH3Cl, reflux, 36 h (5a), Ac2O, DCM, rt, 3 h (5b); (d) 2N NaOH, dioxane, rt, 24 h (6a), 2N
NaOH, MeOH, rt, 24 h (6b); (e) DCC, HOBt, THF, NMM, DMF, rt, 24 h
Kotha, S.; Mohanraja, K.; Durani, S. Chem. commun. 2000, 1909.
35
[2+2+2] Cycloaddition of Dialkenyl Based Peptides
RHN
HN
O
COOMe
6a (R=Boc)
H
BocHNHN
OCOOMe
H
70%
OHHO
a
Reagents and conditions: (a) 1,4-butynediol/EtOH, Wilkinson's catalyst, reflux 4 days
CO Leu OMe
NHBoc
OH
OH
CO D-Val OMe
NHBoc
OH
OH
CO D-Leu NHMe
NHBoc
OH
OH
CO D-Val Leu OMe
NHBoc
OH
OH
CO Leu Ala NHMe
NHBoc
OH
OH
(Ph3P)3RhCl
2-butyn-1,4-diolK2CO3, CH3CN NTs
CO2Et
NTs
CO2EtHO
HO
NTs
CO2EtBr
Br
PBr3, benzene
Rongalite
DMF
RT
TsHN CO2Et
Br
NTs
CO2EtO
SO
Kotha, S.; Banerjee, S. Synthesis 2007, 1015
New entry to tetrahydroisoquinoline (Tic)
amino acid derivatives
O
O
NTs
CO2Et
O
NTs
CO2EtMe
Me
O
O
NTs
CO2Et
O
O
O
NTs
CO2Et
NTs
CO2EtMeO2C
71% 72%
77%
82%
70%
MeO2C
Various (Tic) amino acid derivatives prepared
40
Synthesis of O- Propargylated Compounds
OHO
propargylbromide,acetone
K2CO3,reflux
R = 4-CO2Et, H, 4-Me, 4-OMe, 4-tBu
RR
1 2
Entry
Table I - Preparation of substituted phenylpropargyl ether 2a-2e
1 2
a R = 4-CO2Et R = 4-CO2Et 27 98
b R = H R = H 23 97
c R = 4-Me R = 4-Me 22 72
d R = 4-OMe R = 4-OMe 22 87
e R = 4-tBu R = 4-tBu 22 95
Time(h) Yield(%)
41
Alkyne Trimerization of O-Propargylated Precursors
O O
O
O
O
O
O
+
Cl2(PPh3)2Ru=CHPh
toluene, 80 °C
R = 4-CO2Et, H,4-Me, 4-OMe, 4-tBu
R
R
R
R
R
R
R
+
OH
R
23 4 1
Entry
Table II - Preparation of 1,3,5- & 1,2,4-triaryloxymethylbenzenes 3a-3e, 4a-4e & depropargylated
product 1a-1e
a 4-CO2Et 7.5 54 60 37 1.6:1 1.3:1
b H 5.0 27 37 25 1.5:1 1.3:1
c 4-Me 5.0 26 33 13 2.6:1 1.4:1
d 4-OMe 5.0 24 71 - - 1.2:1
e 4-tBu 5.0 50 24 22 1.1:1 1.4:1
Time(h)G-I(mol%)
Yield(%)3&4
Yield(%)1
3&4:1 4:3R
42
Independent synthesis of 1,3,5-Triarylbenzene derivatives
Entry
Table III - Preparation of 1,3,5-triaryloxymethylbenzenes3a-3e from 6 and 1
1 3 Yield(%)
a R = 4-CO2Et R = 4-CO2Et 7 87
b R = H R = H 5 100
c R = 4-Me R = 4-Me 5 99
d R = 4-OMe R = 4-OMe 5 84
e R = 4-tBu R = 4-tBu 8 95
Time(h)
Br
Br
Br
OH
+
R = 4-CO2Et, H, 4-Me, 4-OMe, 4-tBu
acetone, K2CO3
reflux
O
O
O
316R
R
R
R
43
Identification of Regioisomers
1H NMR spectrum of trimerized product (benzylic protons are shown)
LC-Mass spectral studies
Figure 1 Figure 2 Figure 3
635.2611.5
O
O
O
EtO2C
CO2Et
EtO2C
O
O
O
O
O
O
EtO2C
CO2Et
EtO2C
CO2Et
CO2Et
EtO2C
CO2Me
CO2Me
CO2Me
CO2Me
G-I
Tolueneref lux
X
X
XX
+
Kotha, S. Vittal, S. Mobin, S. Synthesis 2011, 1581
CO2Me
CO2Me
Cl
Cl
CO2Me
CO2Me
Br
Br
CO2Me
CO2Me
I
I
CO2Me
CO2Me
MeO
MeO
Ruthenium-Mediated [2+2+2] Cyclotrimerization
45
What is Suzuki Coupling reaction?
Recent application of the Suzuki-Miyaura cross-coupling
reaction in organic synthesis
Kotha S.; Lahiri, K.; Kashinath, D. Tetrahedron 2002, 58, 9633.(814 citations)
Most requested documents-chemistry and related science
CAS Science Spotlight 2003 & 2004http://www.cas.org/spotlight
Best review paper award 2005 : I. I. T., Bombay
X
R1
B(OH)2
R2
+R1 R2
X=I, Br, OTfz
Pd(0)
a) Miyaura, N.; Suzuki, A. JCS. Chem. Commun. 1979, 866
b) Miyaura, N.; Yamada, K.; Suzuki, A. Tetrahedron Lett. 1979, 3437.
c) Miyaura, N.; Yanagi, T.; Suzuki, A. Synth. Commun. 1981, 513.
CO2Me
CO2Me
X
X
CO2Me
CO2Me
Y
Y
X = Br, I
Suzuki coupling
CO2Me
CO2Me
OHC
OHC
CO2Me
CO2Me
H3COC
H3COC
CO2Me
CO2Me
MeO
MeO
Reaction conditions: 4-YC6H4B(OH)2, Pd(PPh3)4 (5–9 mol%), THF–toluene–H2O (1:1:1),
Na2CO3, 90 C.
Publications in [2+2+2] area
S. Kotha, N. Sreenivasachary
Synthesis of 1, 2, 3, 4-tetrahydroioquinoline-3-carboxylic acid (Tic) derivatives by
cycloaddition approaches.
Eur. J. Org. Chem. 3375, 2001.
S. Kotha, E. Manivannan
Synthesis of spiro-indanes by cycloaddition strategy.
J. Chem. Soc. Perkin Trans. 1, 2543, 2001.
S. Kotha, N. Sreenivasachary
A new synthetic approach to 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives
via a [2+2+2] cycloaddition reaction.
Bioorg. Med. Chem. Lett. 10, 1413, 2000
S. Kotha, K. Mohanraja, S. Durani
Constrained phenylalanine peptides via a [2+2+2]-cycloaddition strategy
Chem. Commun. 1909, 2000.
S. Kotha, E. Brahmachary
Synthesis of unusual α-amino acids via a [2+2+2] cycloaddition strategy.
Tetrahedron Lett. 38, 3561, 1997
1
2
3
4
5
S. Kotha, E. Brahmachary
Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy.
Bioorg. Med. Chem. 10, 2291, 2002.
S. Kotha
The building block approach to unusual -amino acid derivatives and peptides.
Acc. Chem. Res. 36, 342, 2003
S. Kotha, K. Lahiri
Application of the Suzuki–Miyaura cross-coupling reaction for the modification of
phenylalanine peptides.
Biopolymers 69, 517, 2003
S. Kotha, E. Brahmachary
Synthesis and reactions of silicon containing cyclic α-amino acid derivatives.
J. Organomet. Chem. 689, 158, 2004.
S. Kotha, A. Ghosh
Cycloaddition approach to indane based α-amino acid derivatives.
Tetrahedron 60, 10833, 2004
S. Kotha, N. Sreenivasachary.
Synthetic approaches to tetrahydroisoquinoline-3-carboxylic acid derivatives.
J. Indian. Inst. Sci. 81, 277, 2001
6
7
8
9
10
11
S Kotha, S. Misra, S. Halder
Benzannulation.
Tetrahedron 10775, 64, 2008.
S. Kotha, E. Brahmachary, K. Lahiri
Tansition metal-catalyzed [2+2+2] cycloaddition and application in organic synthesis.
Eur. J. Org. Chem. 4741, 2005.
S. Kotha, S. Banerjee
Synthesis of Novel 1, 2, 3, 4-tetrahydroioquinoline-3-carboxylic acid (Tic) derivatives through
the application of Rongalite: A Synergetic Combination of [2+2+2] and [4+2]-Cycloaddition Reactions.
Synthesis 1015, 2007
S. Kotha, A. Deb, K. Lahiri, E. Manivannan
Recent synthetic approaches to spirocyclics.
Synthesis 165, 2009
S. Kotha, A. Ghosh
A Diels–Alder approach for the synthesis of highly functionalized benzo-annulated indane-based
α-amino acid derivatives via sultine intermediate.
Tetrahedron Lett. 45, 2931, 2004.
12
13
14
15
16
S. Kotha, N. G. Krishna, S. Misra, P. Khedkar
Synthesis of linearly and angularly fused constrained alpha amino acid derivatives.
Synthesis (accepted)
S. Kotha, V. Seema, S. M. Mobin
Synthesis of biaryl derivatives by using ruthenium mediated [2+2+2] cyclotrimerization and
Suzuki-Miyaura cross-coupling as key steps.
Synthesis 2011, 1581.
S Kotha, P. Khedkhar
A diversity oriented approach to diphenylalkane derivatives by strategic utilization of [2+2+2]
Cyclotrimerization, cross–enyne metathesis and Diels–Alder reaction.
Eur. J. Org. Chem. 730, 2009.
S. Kotha, D. Bansal, R. Vinodkumar
Synthesis of symmetrical and unsymmetrical trisubstituted benzene derivtives through ring-closing
alkyne metathesis strategy and depropargylation under various catalyst conditions.
Indian. J. Chem. 225, 2009.
S Kotha, P. Khedkhar
Differential reactivity pattern of hybrid o-quinodimethane precursors: Strategic expansion to
annulated benzocycloalkanes via Rongalite
J. Org. Chem. 5667, 74, 2009.
17
18
19
20
21
Ph. D students
1. Dr. E. Brahmachary
2. Dr. N. S. Chary
3. Dr. R. Sivakumar
4. Dr. E. Manivannan
5. Dr. S. Halder
6. Dr. (Ms). K. Lahiri
7. Dr. K. Mohanraja
8. Dr. M. Behera
9. Dr. A. Ghosh
10. Dr. A. C. Deb
11. Dr. D. Kasinath
12. Dr. K. Mandal
13. Dr. S. Banerjee
14. Dr. K. Singh
15. Dr. V. Shah
16. Dr. (Ms). P. Khedkar
17. Dr. M. K. Dipak
18. Mr. S. Vittal
19. Ms. S. Misra
20. Ms. A. Tiwari
21. Ms. N. G. Krishanan
22. Mr. A. S. Chavan
23. Ms. D. Bansal
24. Mr. M. P. Meshram
25. Mr. G. Waghule
26. Mr. M. Shirbhate
27. Mr. R. Ali
28. Mr. Ch. Ajaykumar
1. Mr. S. A. Jothi
2. Mr. G. Giridharan
3. Ms. R. Deshpande
4. Ms. M. S. Subhashi
5. Mr. S. R. Subbaiah
6. Mr. A. Mehta
7. Mr. C. Chatterjee
8. Mr. AP. Suresh Babu
9. Ms. S. Bhattacharjee
10. Mr. P. Charkrabarty
11. Mr. T. Kesharwani
12. Mr. A. Singh
13. Mr. V. Rane
14. Mr. A. Pal
15. Mr. T.T. Rao
16. Mr. M. Banik
17. Mr. R. K. Das
18. Mr. V. Shukla
19. Mr. U. Basu
20. Mr. K. Raju
21. Ms. G. Rama
22. Mr. P. K. Shee
23. Ms. B. Mandal
M. Sc. students
1. Dr. T. Ganesh
2. Dr. R. Vinod. Kumar
3. Dr. S. Kumar
4. Dr. (Ms). K. Lahiri
5. Dr. D. Nagaraju
6. Dr. (Ms). P. Khedkar
7. Dr. T. Niranjan
8. Dr. Venu Srinivas
Post-doctoral students
Project/Summer students
1. Mr. S. M. Husian
2. Mr. M. J. Rihan
3. Ms. M. Sridevi
4. Mr. A. Pradeesh
5. Ms. B. V. Lakshmi