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MED 525: Malignant Hematology SmallGroup Cases

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MED 525: Malignant Hematology Small Group Cases Students Version

Monday, May 5, 201

"#ti$ity 2: Ma#ro#yti# "nemia 8Myelodysplasti# Syndrome and "#uteMyeloid eu6emia9

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earning /;e#ti$es:

1. ;rovide a differential diagnosis for macrocytic anemia.

2. 4escribe which aspects of a history, physical e

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3. /ecogni%e that myelodysplastic syndromes may present as cytopenias and can progress to acute leukemia.

4. =nderstand myelodysplastic syndromes and why a bone marrow e

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MED 525: Malignant Hematology Small Group Cases StudentsVersionMonday, May 5, 201

0his patient is diagnosed with myelodysplastic syndrome based on the morphologic findings of her bone marrowe

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#

MED 525: Malignant Hematology Small Group Cases Students Version

Monday, May 5, 201

"#ti$ity ): solated Cer$i#al ympadenopaty 8ympoproli!erati$e7eoplasms9 2ase material prepared by 4r. :. ;eters

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earning /;e#ti$es:

1. 4evelop an age-appropriate differential diagnosis for isolated cervical lymphadenopathy.

2. 4escribe which aspects of a history, physical e

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3. Elicit a history of >? symptoms using established criteria.

4. 4istinguish between diagnostic strategies &e.g.* fine needle aspiration, core biopsy, e

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showed lymphoma?

6. Were there any features in the initial history and physical examination that might have prompted a request for

an excisional lymph node biopsy instead of a fine needle aspiration biopsy?

MED 525: Malignant Hematology Small Group Cases Students Version

Monday, May 5, 201

"#ti$ity : eu6o#ytosis and Splenomegaly 8Myeloproli!erati$e7eoplasms9 2ase material prepared by 4r. M. odna

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earning /;e#ti$es:

1. /ecogni%e that non-hematologic and both malignant and benign hematologic disorders may present withsplenomegaly.

2. 4escribe which aspects of a history, physical e

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3. 4escribe the speciali%ed molecular testing available to help diagnose a myeloproliferative disorder and why it mightrepresent important targets for therapy.

4. 4istinguish between myelodysplastic syndrome &M41', myeloproliferative neoplasms, and myelofibrosis.

5. 4escribe when patients with leukocytosis andBor splenomegaly should be referred to a specialist for further work-upand management.

: si

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MED 525: Malignant Hematology Small Group Cases StudentsVersionMonday, May 5, 201

6. What features in this peripheral blood film have led the hematopathologist to suggest a myeloproliferative

disorder?

7. Which myeloproliferative neoplasm could it be?

8. ,he peripheral blood film displays -leukoerythroblastic features )characteri%ed by nucleated erythrocytes&

tear drop forms& and immature leukocytes*& normochromic normocytic anemia& and thrombocytopenia. Whatdoes this mean?

9. What special molecular diagnostic tests would you request if you think that this patient has a

myeloproliferative neoplasm?

0he internist arranges for the patient to have a bone marrow e

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