8th International Conference
on Oxidative Stress in Skin Biology and
Medicine
Andros, Greece
6-9 September 2018
Co-organizers:
SCIENTIFIC PROGRAM
Dedicated to the Memory of our Beloved Lester Packer
Lester Packer, Aug 28, 1929 – July 27, 2018, died peacefully at his home in Orinda,
CA with his wife Anne Packer attending to him. He was alert, thoughtful, and
inquisitive until two days before he died. Born and raised in the Bronx in NY, he
earned his Ph.D. from Yale University studying bacterial hydrogenases. Subsequently,
he did postdoctoral studies on mitochondria, enzymology, and biological oxidations at
the Johnson Foundation at the University of Pennsylvania and began his academic
career at Southwestern Medical School in Dallas. In the early 1960s, Lester moved to
The University of California, Berkeley where he became a professor of Physiology-
Anatomy and later of Molecular and Cell Biology. He published over 700 papers
spanning a vast range of biological research. His early research focused on electron
transport in enzymes and mitochondria and this led to studies on oxidants, oxidative
stress, and the cellular adaptive responses associate with such stresses. The
relationships between a myriad of pathologies and errant oxidant production and
inadequate antioxidant protection led to his well-known research in antioxidants both
vitamins and natural food supplements designed to enhance human health. Professor
Packer was the author of many books, editor of the series Oxidative Stress and
Disease, served on numerous editorial boards, and is often best known as the
organizer of dozens of international meetings where he fostered the interactions
between senior scientists and students. Professor Packer developed the Antioxidant
Network, a concept that engaged many institutions and colleagues all over the world
and that materialized as conferences with a focus on redox biology. His high intellect
was complimented by boundless energy, unrelenting enthusiasm and superb
mentoring of a generation of scientists to study cellular redox processes. He will be
thoroughly missed by his family, friends, colleagues and students. (Enrique Cadenas
and John Maguire 2018).
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September 6, 2018
Thursday
09:0
0-
10:0
0
Welcome Cocktail
Registration
Poster arrangements
10:0
0-1
1:0
0
OPENING OF THE CONFERENCE FROM THE LOCAL AUTHORITIES.
Welcome by:
Prof Dr G. Wondrak, Conference Chairman
As. Prof. Dr M. Rallis
Reverend Ioannis
Dr. Th. Sousoudis Mayor of Andros
D. Lotsaris, Andros Prefect
Dr E. Alexandratou
Dr A. Petri
Mrs A. Tsatsomoirou
Mrs K. Korachai.
Introduction by:
Prof Dr J. Anastassopoulou.
11:0
0-1
2:0
0 OPENING CONFERENCE LECTURE
Chairman: S. Werner
Wondrak Georg
Pharmacological modulation of cellular stress response pathways for skin
photoprotection and photochemoprevention
5
OXIDATIVE STRESS – ANTIOXIDANTS – DIET
Chairmen: H. Black, E. Polychronopoulos
12:0
0-1
3:3
0
Black Homer Background to studies on the Anti and Pro-
Carcinogenic Mechanisms of Carotenoids
SE
SS
ION
1
Truscott George Photo- and high energy radiation protection by
dietary carotenoids
Virgili Fabio
Need (more than) two to tango: Multiple
molecular tools acting to adapt cells to changes
in oxygen availability
Polychronopoulos
Evangelos EDCs public health implications vs longevity
13:3
0-1
4:0
0 SPECIAL LECTURE
Chairman: F. Virgili
Sastre Juan
Regulation of the antioxidant defense by p38alpha
14:00-
15:00 Light lunch
POSTER SESSION I
Chairman: J. Anastassopoulou
15:0
0-1
6:0
0
Edge Ruth
Oxygen effects on antioxidant protection
against free radicals by a range of dietary
carotenoids
PO
ST
ER
SE
SS
ION
I
Zdunić Gordana
Chokeberry leaves: Activity guided
fractionation of extract and its antioxidant
and antidiabetic activity
Gođevac Dejan
NMR-based metabolomics combined with
dry-column flesh chromatography to
identify cytotoxic metabolites from
amphoricarpos autariatus
6
Šavikin Katarina Antioxidant and antityrosinase activity of
different extracts of Sideritis raeseri boiss
Tomou
Ekaterina-
Michaela
Phytochemical investigation of the fern
Asplenium ceterach L. (Aspleniaceae)
Grafakou Maria-
Eleni
Ten metabolites isolated from Calea
jamaicensis (L.) L.
Barda Christina Comparative study of two Greek endemic
species of the genus Crepis L. (Asteraceae)
Papakosta-
Tsigkri Lydia &
Pontillo Nefeli
Antioxidant activity-guided comparative
study of different methodologies for the
extraction of Rosmarinus officinalis
Soubasi Kalliopi
& Tsiouma Alexia
Study of the effects of the olive leaf
extracts on the treatment of the psoriasis
Ganos Christos
Antifungal activity of Pistacia lentiscus L.
growing in the island of Chios - Greece
against Malassezia sps
Ganos Christos
Phytochemical study on Greek endemic
Rindera graeca aerial parts. Antioxidant
activity
CANCER, OXIDATIVE STRESS AND THERAPY
Chairmen: G. Bauer, N. Chondrogianni
16:0
0-1
7:0
0
von Woedtke
Thomas
Plasma medicine: innovative physics for
medical applications
SE
SS
ION
2
Bauer Georg
Signal amplification by tumor cells: clue to
the understanding of the antitumor effects of
cold atmospheric plasma and plasma-
activated medium
Demonacos
Costas
Evasion of immunorecognition by breast
cancer cells under diverse oxidative stress
conditions is facilitated by the function of
Protein Disulphide Isomerases (PDIs)
17:00-
17:30 Coffee Break
7
SKIN AGEING
Chairmen: M. Meinke, F. Gruber
17:3
0-1
9:0
0
Kletsas Dimitris UVB-mediated cytotoxicity and premature
senescence in skin fibroblasts
SE
SS
ION
3
Trougakos
Ioannis
Functional cross talk between proteostatic,
mitostatic and metabolic pathways - the role
of Nrf2.
Gruber Florian
Oxidized lipids as markers and mediators in
skin stress and senescence of cutaneous
cells
Chondrogianni
Niki
How diet-derived compounds can help in
the battle against ageing and protein
aggregation: The vital role of the
proteasome
Bause Alexandra Entrepreneurial opportunities in molecular
aging research
19:0
0-1
9:3
0 SPECIAL LECTURE
Chairman: E. Skaltsa
Vasilopoulos Georgios
In search of genuine merits at footprints of Pharmaceutical Science and
deaconship
19:3
0-2
0:3
0 ROUND TABLE I
A. Ntalianis (coordinator), H. Black, E. Polychronopoulos,
M. Rallis
From skin and face transplantation to heart
transplantation; Ethical considerations
RO
UN
D
TA
BL
E I
20:30… Dinner
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September 7, 2018
Friday
11:00-
11:30 Coffee break
11:3
0–12:0
0 LECTURE OF THE DAY
Chairman: D. Kletsas
Werner Sabine
The bright and the dark sides of Nrf2 in wound healing and skin
carcinogenesis
PHOTODYNAMIC THERAPY, NANOPARTICLES AND SKIN
Chairmen: E. Alexandratou, T. Theodossiou
09:0
0-1
1:0
0
Baldea Ioana
Antitumor effects mediated by silver
nanoparticles on oral dysplastic keratinocytes-
in vitro study
SE
SS
ION
1
Alexandratou
Eleni
Evaluation of four synthetic curcumin
derivatives as potential photosensitizers:
Photophysical and photodynamic properties
Theodossiou
Theodosios
A hybrid treatment of cancer by a combination
of hypericin PDT and tamoxifen
administration
Gimisis
Thanasis
Nanomolar inhibitors of glycogen
phosphorylase as in vitro fluorescent probes in
cancer cells
Kavetsou Eleni Encapsulation of bioactive coumarin
analogues in various nanocarriers
9
WOUND HEALING – OXIDATIVE STRESS
Chairmen: S. Werner, A. Korac
12:0
0–13.3
0
Munir Saira
The adaptive response of mesenchymal
stem cells on neutrophil activation via
TRL-4 mediated sensing at the wound site
SE
SS
ION
2
Martin Paul ROS as an immune cell attractant to
wounds and cancer
Weavers Helen
Understanding the inflammatory response
to tissue damage in Drosophila: a complex
interplay of pro-inflammatory attractant
signals, developmental priming and
cytoprotection
Grigoropoulos
Andreas
Clinical evaluation of wound healing
capacity of isopod Ceratothoa oestroides
oil extract.
POSTER SESSION IIA
Chairman: I. Antoniadou
13:3
0-1
4:0
0
Grigalavicius
Mantas
The effect of exposing keratinocytes and
skin cancer cells to combined UVA-UVB
radiation on DNA damage and cell
apoptosis
PO
ST
ER
SE
SS
ION
IIA
Ménard Mathilde
Evaluation of cercosporin as a potential
photosensitizer on human tumour cell
lines
Katopodi Annita New bioactive compounds sharing the
coumarin framework as a common
structural feature
Kostopoulou
Ioanna
Synthesis of phenolic esters and
evaluation of their photoprotective
activity
Nemtsa Despoina
&
Papakonstantinou
Sofia
Water and propylene glycol isopode
Ceratothoa oestroides extracts: Wound
healing efficacy
10
14:00-
15:00 Light lunch
POSTER SESSION IIB
Chairman: I. Antoniadou
15:0
0-1
5:3
0
Aritzidou
Konstantina-
Maria
Resveratrol: Formulation, in vitro
penetration and in vivo anti-inflammatory
assessment
PO
ST
ER
SE
SS
ION
IIB
Tesseromatis
Christina
Hypericum perforatum for experimental
skin burns treatment in rats
Maidoni Xanthi,
Giannakopoulos
Eystathios
The contribution of enzymes in debridement
and wound healing
Mpita Melpo &
Kosmoglou
Georgios
Nutrition and psoriasis treatment
Andreou
Nikolaos Radiations and wound healing
Giallousis
Nikolaos
Larvae of Lucilia sericata: Sterilization
process and effects on wound healing – A
pilot study in mice
16:00-
17:00
LESTER PACKER MEMORY
Chairmen: G. Wondrak, G. Valacchi, F. Virgili, M. Rallis
17:00-
17:30 Coffee Break
15:3
0–16:0
0 SPECIAL LECTURE
Chairman: E. Zouridaki
Karamanou Marianna
Skin aging: old concepts and therapeutic approaches
11
ENVIRONMENT, RADIATION AND SKIN
Chairmen: G. Valacchi, B. Korac
18:0
0-1
9:4
5
Marrot
Laurent
Oxidative and photo-oxidative stress in skin
exposed to atmospheric pollution
SE
SS
ION
3
Baciou Laura Oxidative stress resistance and ionizing
radiation damages of human neutrophils
Meinke
Martina
In vivo radical production due to sun light for
different skin types
Rolfes
Katharina
Maria
The UVB-activated arylhydrocarbon receptor
protects epidermal keratinocytes against
UVA-induced phototoxicity of 6-
formylindolo[3,2-b]carbazole (FICZ)
Sherratt
Michael
Protein degradation in human skin: predicting
pathways and targets
Tanis Orestis
The influence of UV irradiation on diabetic
mice skin. A vibrational FT-IR and Raman
spectroscopic study
19:4
5-2
1:0
0 ROUND TABLE II
G. Wondrak (coordinator), G. Valacchi, L. Marrot, M.A.
Lila, I. Trougakos, L. Baciou, K. Burke
The skin exposome: From environmental oxidative stressors to
molecular interventions
RO
UN
D T
AB
LE
II
17:3
0–18:0
0 LECTURE OF THE DAY
Chairman: M. A. Lila
Valacchi Giuseppe
SRB1: epithelial redox target of pollution induces tissue damage
12
September 8, 2018
Saturday
OXIDATIVE STRESS, DISEASES AND ASSESSMENT METHODS
Chairmen: A. Petrou, A. Kourounakis
09:0
0-1
1:0
0
Petrou Athina
A possible role for singlet oxygen in the
degradation of various antioxidants. A meta-
analysis and review of literature data
SE
SS
ION
1
Theofanides
Theophilos
Fourier transform infrared and Raman
spectra of human skin for the study and
recognition of diseases in skin
Anastassopoulou
Joanna
Oxidative stress influenced biocorrosion and
the effect on atherosclerosis, cancer and
melanoma
Kostopoulou
Ioanna
Novel hybrid antioxidants sharing the
structural framework of 4-hydroxy-2-
quinolinone
Hanna Rebecca
Optimised detection of mitochondrial DNA
damage and antioxidant mediated protection
in human skin
Demertzis
Nikolaos
Use of molecularly imprinted polymers for
the rapid and accurate detection of sepsis
Guerriero Giulia Frog skin biopsy as non invasive method for
environmental health monitoring.
Karamani
Christina &
Dimou
Aikaterini
Optimization of psoriasis mouse models: A
comparative study
11:00-
11:30 Coffee break
13
11:3
0–12:0
0 LECTURE OF THE DAY
Chairman: G. Bauer
Korac Bato
Molecular basis of surviving/adaptation in deep hibernation: A skin
lesson
OXIDATIVE STRESS, SIGNALING & DISEASES
Chairmen: E. Fischer – Fodor, E. Zouridaki
12:0
0-1
3:3
0
Piroska Virag Immunotherapy in malignant melanoma:
where do we stand?
SE
SS
ION
2
Fischer-Fodor
Eva
The in vitro modulation of the angiogenic
pathways by chemotherapy in vascular
endothelial vein cells - An experimental
model of infantile hemangioma
Makrantonaki
Evgenia
Influence of IGF-I and oxidative stress on
Wnt signaling in epidermal stem cells.
Burke Karen Oral telomerase activator : A review and
effect on UV-induced carcinogenesis
Mamareli
Vasiliki
The influence of oxidative stress on
cardiolipin deregulation and amyloid
protein formation of coronary arteries in
diabetic patients
13:3
0–14:0
0
SPECIAL LECTURE
Chairman: T. Gimisis
Dadeshidze Inga
COST European Cooperation in Science and Technology and
COST Actions: opportunities for biomedical networks and their
impact
14:00-
15:00 Light lunch
14
POSTER SESSION III
Chairman: T. Theophanides
15:0
0-1
6:0
0
Dimas
Dimitrios
Chemical investigation of bioactive non polar
Melissa officinalis L. ssp. altissima extract
against psoriasis in vivo
PO
ST
ER
SE
SS
ION
III
Kotroni
Eleftheria &
Simirioti
Eleftheria
Anti-inflammatory activity of Pinus
halepensis extract loaded on topical patches
Pritsas
Aristiedes Chemical profile of Stachys iva Griseb
Tzara Ariadni
Polyaromatic benzothiazine derivatives with
antioxidant, antihyperlipidemic and
antiinflammatory activity
Xanthopoulos
Dimitrios
Novel antioxidant/anti-inflammatory
multiactive thiomorpholine derivatives.
Grafakou
Maria-Eleni
Chemical analysis of the essential oil of
Hypericum jovis, a narrow endemic species
of Crete (Greece).
Tomou
Ekaterina-
Michaela
Chemical profile of Sideritis euboea HELDR
Karamani
Christina
Efficacy of Melissa officinalis extracts to
psoriasis treatment – An experimental
approach
Karamani
Christina
An extract of the isopod Ceratothoa
oestroides exhibits therapeutic potency for
psoriasis
Terezaki
Asimina
Potential healing properties of bee products
to thermal and sun burns
Kesente Maria
Christina
Comparative in vivo study of the efficacy of
four topical applications in a model of atopic
dermatitis in hairless mice
15
Giakoumaki
Maria
Chronic UV irradiation induced oxidative
stress in the skin of diabetic hairless mice
Deli Eleni Effect of anti-inflammatory/antioxidant agent
on diabetic hairless mouse skin.
NATURAL PRODUCTS AND SKIN
Chairmen: E. Skaltsa, K. Burke
16:0
0-1
7:3
0
Skaltsa Eleni The contribution of natural products to the
treatment of psoriasis
SE
SS
ION
3
Magiatis
Prokopios
Squalene peroxide: photochemical and
microbial production related to skin
inflammation - Inhibition by olive oil
phenolic ingredients
Lila Mary Ann Blueberries prevent ozone-induced
keratinocytes inflammasome activation
Burke Karen Prevention of environmental damage to the
skin by topical antioxidants
Lagouri Vasiliki
Effects of Greek pomegranate extracts in the
antioxidant properties and storage stability
of kefir
17:30-
17:45 Coffee Break
17:45-
19:15
ROUND TABLE III
E. Zouridaki (coordinator), T. von Woedkte, T. Theodossiou, E.
Makrantonaki
From Bench to Bedside –Is basic research relevant to clinical practice?
19:15-
19:30
CONCLUSIONS
G. Wondrak
21:00 Dinner
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September 9, 2018
Sunday
EXCURSION
10.00 Goulandri’s Museum of Modern Art: Mytaras Painter
11:00 Guided visit in the town of Andros
12:30 – 16:00 Visit to Menites Village – Church of Dormition -
Paraclesis and Lunch
16:00-18:30 Walking Tour - Coffee
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