Sec

tion

for

Nut

ritio

nR

esea

rch

Who

’s in

the

sect

ion

Dr J

onat

han

Swan

nD

r Jia

Li

Dr I

zabe

lle G

arci

aPe

rez

Dr E

d C

ham

bers

Dr E

lain

e H

olm

esD

r Sim

on G

abe

Prof

Gar

y Fr

ost

Dr A

rron

Let

tsD

r Lin

a Jo

hass

onD

r Suz

ie B

arr

Dr K

evin

Mar

shal

l-Wal

sh

Fros

t Gro

up –

Nut

ritio

n, F

ood,

Met

abol

ism•

Die

tary

Ass

essm

ent

•M

etab

olom

ics –

Isab

ell G

arci

a•

Cam

era

- Ben

ny L

o•

Die

tary

Car

bohy

drat

es•

Ferm

enta

ble

carb

ohyd

rate

•In

ulin

pro

pion

ate

este

r•

Rela

tions

hip

betw

een

food

and

the

gut

•In

tuba

tion

tech

nolo

gy•

G-p

rote

in si

gnal

ling

•O

rgan

oid

syste

ms

•Fo

od st

ruct

ure

•D

evel

opm

ent o

f enh

ance

d fe

edin

gsy

stem

s to

supp

ort S

AM

• O

ccup

atio

nal N

utrit

iona

l H

ealth

sw

ellin

g(h

ydra

tion

)di

sint

egra

tion

(mec

hani

cal +

chem

ical

)

stom

ach

time

gast

ric

secr

etio

ns(H

Cl,

peps

in,

etc.

)

rece

ptor

sab

sorp

tio

ninte

stin

e

inte

stin

alse

cret

ions

(HCO

3-,

enzy

mes

, et

c.)

excr

etio

n(w

aste

)

Jona

than

Sw

ann

Rea

der i

n M

icro

biom

ics a

nd H

uman

Dev

elop

men

t

Impa

ct o

f ear

ly-li

fe e

vent

s on

the

deve

lopm

ent o

f the

mic

robi

ome

and

the

host

met

abol

ic sy

stem

and

the

impl

icat

ions

for

heal

th a

nd d

iseas

e

E ar ly - lif e e v e nt s; n ut rit io n al

•B

rain

dev

elop

men

t•

Neu

rolo

gica

l dis

orde

rs•

Gut

hea

lth•

Gro

wth

and

mus

cle

•D

rug

met

abol

ism

•M

etab

olic

regu

latio

n•

Alle

rgie

s•

Circ

adia

n rh

ythm

s

Mai

n R

esea

rch

Aim

sTo

und

erst

and

mec

hani

sms

of b

aria

tric

surg

ery

in o

rder

to s

eek

alte

rnat

ive

non-

inva

sive

treat

men

t for

obe

sity

To e

xplo

re w

hy th

e IB

D a

nd b

aria

tric

surg

ery

patie

nts

have

hig

her c

olon

can

cer r

isk

inor

der t

o m

anag

e th

e ca

ncer

risk

in th

ese

patie

nts

To in

vest

igat

e im

pact

s of

die

tary

com

pone

nts

and

mic

robi

al m

etab

olite

s on

tum

orig

enes

isan

d in

flam

mat

ion

as w

ell a

s nu

tritio

nal i

nter

vent

ion

for r

educ

ing

colo

n ca

ncer

risk

Teac

hing

and

Sup

ervi

sion

UG

BM

B Y

ear 2

: Mod

ule

lead

of

Mic

robi

ome

in H

ealth

and

Dis

ease

(MH

D)

MR

es: s

tream

lead

of M

HD

PhD

: 6 p

rimar

y su

perv

isor

; 5 c

o-su

perv

isor

; 3 o

vers

eas

supe

rvis

or.

IIPTC

: NM

R w

orks

hop

for e

xter

nals

and

PhD

stu

dent

s.D

r Jia

Li

Im

pact

of g

ut-d

eriv

ed S

CFA

s on

who

le-b

ody

met

abol

ism

SCFA

s

Hep

atic

Met

abol

ism

Venous

Metabolom

eArterial

Metabolom

eSkeletal

Muscle

Metabolite

Exchange

Arterial-Venous

Difference

Myo

blas

tPr

olife

ratio

nM

yotu

beD

iffer

entia

tion

1.H

ow d

o SC

FAs

impa

ct h

epat

icm

etab

olic

pro

cess

es?

2.H

ow d

oes

this

influ

ence

the

com

posi

tion

of a

rter

ial b

lood

that

sup

plie

ssk

elet

al m

uscl

e?3.

How

doe

s th

is in

fluen

ce m

etab

olite

cons

umpt

ion

and

rele

ase

in s

kele

tal

mus

cle?

Dr.

Isab

el G

arci

a-Pe

rez

Lect

urer

in P

reci

sion

& S

yste

ms M

edic

ine

NIH

R-Re

sear

ch F

ello

wST

RATi

GRA

D A

cade

mic

Coo

rdin

ator

Rese

arch

Inte

rest:

Per

sona

lised

nut

ritio

n in

clin

ic (N

IHR-

CDF)

Teac

hing

:-S

TRAT

iGRA

D P

hD tr

aini

ng c

ours

es-M

Res i

n H

uman

Nut

ritio

n-M

Res M

icro

biom

e in

hea

lth/ M

Res B

iom

edic

al R

esea

rch

(Jou

rnal

Clu

b)-H

ands

On

NM

R co

urse

from

the

Impe

rial I

nter

natio

nal P

heno

me

Trai

ning

Cen

tre.

Sim

on G

abe

•The

ove

rall

them

e re

late

s to

the

man

agem

ent o

f pat

ient

s with

inte

stin

alfa

ilure

:•M

icro

biom

e an

d m

etab

olom

ics

•Pro

file

in p

atie

nts w

ith in

test

inal

failu

re: e

ffect

on

com

plic

atio

ns (C

VC

infe

ctio

ns, v

enou

s thr

ombo

sis,

liver

dis

ease

)•T

he im

pact

of e

nter

ic fe

edin

g of

the

excl

uded

term

inal

ileu

m a

nd/o

r col

on:

mec

hani

stic

, qua

litat

ive

and

clin

ical

asp

ects

•Clin

ical

(int

erve

ntio

nal)

stud

ies

•A S

tudy

of G

LP-1

ago

nist

, LIr

aglu

tide,

on

decr

easi

ng P

aren

tera

l Sup

port

requ

irem

ents

in p

atie

nts w

ith S

BS

(SLI

PS)

•A p

hase

3 tr

ial i

nves

tigat

ing

the

redu

ctio

n of

par

ente

ral s

uppo

rt (P

S) in

SB

S-IF

patie

nts u

nder

trea

tmen

t with

gle

pagl

utid

e•I

ntes

tinal

tiss

ue e

ngin

eeri

ng (N

PIM

R/S

t Mar

k's/I

C)

Com

puta

tiona

l and

syst

ems m

edic

ine

•App

licat

ion

of m

etab

olic

pro

filin

g te

chno

logi

es to

syst

ems b

iolo

gy a

ndtra

nsla

tiona

l med

icin

e pr

oble

ms

•Dev

elop

men

t of s

tatis

tical

spec

trosc

opy

and

othe

r dat

a pr

oces

sing

met

hods

for d

isco

very

and

dev

elop

men

t of m

etab

olic

bio

mar

kers

for

dise

ase

•Dev

elop

men

t and

app

licat

ion

of d

ata

inte

grat

ion

stra

tegi

es fo

r co-

anal

ysis

of c

ompl

ex m

ultid

imen

sion

al d

atas

ets

•Dev

elop

men

t of m

etho

ds fo

r cha

ract

eriz

ing

met

abol

ic in

tera

ctio

nsbe

twee

n th

e gu

t mic

robi

ome

and

host

, with

app

licat

ion

to a

sses

sing

the

role

of m

icro

biom

e in

hea

lth a

nd d

isea

se.

•Met

abol

ome-

wid

e as

soci

atio

n st

udie

s (M

WA

S) in

mol

ecul

arep

idem

iolo

gy, s

peci

fical

ly e

xplo

ring

the

link

betw

een

hype

rtens

ion,

Proj

ect M

anag

emen

t

•Hep

tare

s•I

PE•M

RC

glo

bal h

ealth

Pro

ject

•BB

SRC

SM

E en

gage

men

t

Geo

rgia

Lev

ey C

entre

for T

rans

latio

nal

Nut

ritio

n an

d Fo

od R

esea

rch

Coo

rdin

ator

Aim

: kee

p th

e C

entre

aliv

e th

roug

hin

crea

sing

aw

aren

ess a

nd re

sear

chco

llabo

ratio

n.

MR

ES in

Clin

ical

Res

earc

h

•Ove

rvie

w•T

he M

Res

in C

linic

al R

esea

rch

is a

n um

brel

la p

rogr

amm

e m

ade

up o

fth

ree

path

way

s. D

iabe

tes a

nd O

besit

y - t

his p

athw

ay in

trodu

ces

mod

ern

inve

stig

ativ

e te

chni

ques

incl

udin

g M

RI a

nd m

etab

olom

ics a

ndpr

ovid

es a

dee

p un

ders

tand

ing

of th

e un

derly

ing

path

ophy

siol

ogy

ofbo

th ty

pes o

f dia

bete

s, an

d ob

esity

.•H

uman

Nut

ritio

n - t

his p

athw

ay p

rovi

des a

gre

ater

insi

ght i

nto

the

acad

emic

, clin

ical

, pra

ctic

al, a

nd re

gula

tory

requ

irem

ents

of h

uman

nutri

tion

and

intro

duce

s the

late

st in

cut

ting-

edge

rese

arch

.•T

rans

latio

nal M

edic

ine

- thi

s pat

hway

exp

lore

s the

cha

lleng

es o

fre

sear

ch in

non

-dru

g in

terv

entio

nal r

esea

rch,

incl

udin

g re

gene

rativ

em

edic

ine,

and

illu

stra

te th

e us

e of

hum

ans a

s an

expe

rimen

tal a

nim

al.

You

also

hav

e th

e op

portu

nity

to in

vest

igat

e w

hy d

rugs

fail

in

Aim •T

o pr

oduc

e sc

ienc

e in

the

field

of n

utri

tion

whi

ch is

of

glob

al im

port

ance

and

inte

rnat

iona

l im

pact