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Seminar yadilette rivera_amherst,mass_oct.18-1 copy

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Oct. 18, 2012 10:30 Refreshments provided by Biology Honor Society Seminars Thursday 10:40 - 11:20 Science Seminar Room 106 MMM By Yadilette Rivera Univ. of Massachusetts Amherst Cayey Alumna L ysosomal storage diseases are disorders FDXVHG E\ GHÀFLHQFLHV RI HQ]\PHV PRVW RI WKHP JO\FRSURWHLQV ZKLFK DUH UHVSRQVLEOH IRU WKH GHJUDGDWLRQ RI VXEVWDQFHV SUHVHQW LQ O\VRVRPHV 7KH O\VRVRPH LV UHVSRQVLEOH IRU FDWDEROLF UHDFWLRQV RI PDFURPROHFXOHV DQG LV DOVR LPSRUWDQW LQ HVVHQ- WLDO PHWDEROLWH SURFHVVLQJ :H VWXG\ WZR KXPDQ VXOIDWDVHV 1DFHW\OJDODFWRVDPLQH VXOIDWH VXO- IDWDVH *$/16 ZKLFK FOHDYHV 2VXOIDWH IURP VXOIDWHG Ơ1DFHW\OJDODFWRVDPLQH RU JDODFWRVH UHVLGXHV DQG 1VXOIRJOXFRVDPLQH VXOIRK\GUR- ODVH 6*6+ ZKLFK FOHDYHV 1OLQNHG VXOIDWH IURP VXOIDWHG JOXFRVDPLQH UHVLGXHV ,Q KXPDQV GHÀ- FLHQFLHV LQ WKHLU DFWLYLWLHV UHVXOW LQ WKH O\VRVRPDO VWRUDJH GLVHDVHV 0XFRSRO\VDFFKDULGRVLV ,9$ DQG ,,,$ :H UHFHQWO\ GHWHUPLQHG WKH ÀUVW FU\VWDO VWUXFWXUHV RI ERWK KXPDQ *$/16 DQG 6*6+ 7KH FU\VWDO VWUXFWXUHV HDFK VKRZ WKH FRQYHUVLRQ RI DQ DFWLYH VLWH F\VWHLQH LQWR D YHU\ UDUH DPLQR DFLG GLK\GUR[\DODQLQH ZKLFK ZH FRQÀUPHG ERWK E\ FU\VWDOORJUDSK\ DQG PDVV VSHFWURPHWU\ 7KH VWUXF- WXUHV UHYHDO KRZ GHIHFWV LQ WKH SURWHLQV OHDG WR WKH GLVHDVHV 3URWHLQ FU\VWDOORJUDSK\ VXFFHVV DQG JUDGXDWH VFKRRO VXFFHVV KDYH PDQ\ DVSHFWV LQ FRPPRQ %HUQKDUG 5XSS VD\V LQ KLV DUWLFOH Maximum- likelihood crystallization ´QR PDWWHU KRZ VRSKLVWL- FDWHG RXU UHDVRQLQJ DQG VWDWLVWLFV DUH RQH FDQ RQO\ LQFUHDVH WKH SUREDELOLW\ RI FU\VWDOOL]DWLRQ VXFFHVV RU LQFUHDVH WKH GHJUHH RI EHOLHI LQ LW EXW QHYHU JXDUDQWHH WKH VXFFHVV IRU DQ\ SDUWLFXODU SURWHLQµ 6XFFHVV LQ JUDGXDWH VFKRRO LV JRYHUQHG E\ WKH VDPH SULQFLSOHV 7KHUHIRUH DOWKRXJK WKHUH LV QR JXDUDQWHH IRU VXFFHVV \RX FDQ GHÀQLWHO\ LQFUHDVH WKH SUREDELOLWLHV LQ PDQ\ ZD\V ,Q WKLV VHPLQDU ZH ZLOO GLVFXVV ZKDW WKHVH SUREDELOLWLHV DUH DQG KRZ WR LQFUHDVH WKHP 7KHVH WRROV DUH YDOXDEOH IRU JHW- WLQJ LQWR JUDGXDWH VFKRRO JHWWLQJ \RXU GHJUHH DQG ORRNLQJ IRU MRE RSSRUWXQLWLHV Against All Odds Challenges in Protein Crystallography and Graduate School Seminar
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Page 1: Seminar yadilette rivera_amherst,mass_oct.18-1 copy

Oct. 18, 2012

10:30 Refreshments provided by Biology Honor Society

Seminars – Thursday 10:40 - 11:20

Science Seminar Room 106 MMM

By Yadilette RiveraUniv. of Massachusetts Amherst

Cayey Alumna

Lysosomal storage diseases are disorders FDXVHG�E\�GHÀFLHQFLHV�RI�HQ]\PHV��PRVW�RI�

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Against All Odds Challenges in

Protein Crystallography and Graduate School

Seminar

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