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Serotonin Syndrome 06.24.2015

Date post: 07-Aug-2018
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     THE ACUTELY ALTERED TEEN

    Morning

    Erin Helm

    Fmil! M

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    H$%

    1& !er ol" 'emle

    (ro)g*t to ED +! *er 't*er

    ,)""en onset o' 'lling- #on')sion-

    e.ent)ll! .omiting

    A#ting normll! *en s*e got *ome 'roms#*ool

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    MED%CAL AND ,0C%ALH%,T0RYDepression

    ,trte" #o)nseling lst mont*

    $ro# 2 mg 3"!

     Tro"one 5 mg 3*s prn insomni

    ,el'in)r!

    2 mont*s o' #)tting

    Lst time 2 "!s go

    ,trong 'mil! *istor! o' mentl illness n" s)i#i"e

    Li.es it* grn"prents *o *.e #)sto"! ,ees "" reg)lrl!

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    E7AM 28 9AT$RE,ENTAT%0N: T &;2 HR 160. RR 25 ($ 112/52 ,02 EN8 Sleepy, wakes to voice. Slurred speech. Confused.Tangential.

    EYE,8 $)pils & mm- re#ti.e ro!inent ocular clonus "ilateraE0M%

    HENT8 ?NL

    C@/$ULM8 T#*!#r"i#

    A(D0MEN8 ?NL

    NEUR08 #ine tre!or with activity. $or!al %& tone. 'ncreasetone. 6 "eats of induci"le ankle clonus "ilaterally. )* patell+TRs. ta-ic.

    ,%N8 rm n" B)s*e" C)ts #ross UEs

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    D%FFERENT%AL D%A>N0,%,

    ?

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    D%FFERENT%AL D%A>N0,%,

     Toi#%ngestions8 nti#*olinergi#- s!mpt*omimeti#- sli#!ltes- serotonins!n"

    ?it*"rl sttes8 (r+it)rtes- et*nol 9DTs:- se"ti.e*!pnoti#s

     En"o8 T*!roi" storm

     %D8 Tetn)s- meningitis- sepsis

     Ne)ro8 ,troe- t)mor

     Mis#8 Mlignnt *!pert*ermi- ne)rolepti# mlignnt s!n"

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    ?0R U$

     C(C8 Norml (M$8 Norml

     C8 Norml

     @(>8 ;&4/&&/65/1;2

     ,er)m to8 Negti.e Et0H- #etminop*en- sli#!lte

     Urine to8* C, * piate

     Urine pregnn#!8 Negti.e

     E>8Sinus tachycardia. Norml T#

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    ADD%T%0NAL H$%

     >rn"p #lls it* more in'ormtion

     Re#ent s)i#i"l t*rets

     A"mits to n ingestion o' *n"')l o'

    'rom lo#l gro#er! storeG $res#ription pills #o)nte"- ll ##o)nte"

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    ADD%T%0NAL H$%

     Clle" $oison Control +# it* ""itionl in'orm

     Cons)lte" toi#olog!

     Lerne" t*t+&/TR&THRH$8 C)ses 'lse positi.e "r)g s#reens

     %s "isso#iti.e generl nest*eti# *ll)#it *ig* "oses

     %s *t i"s t*ese "!s re "oing 'or ')n

     ?*en mie" it* serotonergi# me"s- #n #

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    ,ER0T0N%N,YNDR0ME

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    FEATURE, 0F ,ER0T0N%N,YNDR0ME

    Cogniti.e/(e*.iorl Confusiondisorientation 54=

      Agittion/irrit+ilit! &5=

      Com 2K=

      Aniet! 16=

      H!pomni/sei)res/

    *ll)#intions

    15=

    A)tonomi#

      H!pert*ermi 46=

     +iaphoresis 46=

      Sinus tachycardia 41=

      H!pertension &&=

      T#*!pne/m!"risis 2;=

    Ne)rom)s#)lr yoclonus Hyperre3e-ia

     usclerigiditytre!or  H!per#ti.it!/

    restlessness ta-ia

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    HUNTER ,ER0T0N%N T07%C%TYCR%TER%A

    %n ptients it* non ingestion o' serotonergi# gent 9one o''olloing:8

     ,pontneo)s #lon)s

     %n")#i+le #lon)s gittion or "ip*oresis

     cular clonus * agitation or diaphoresis Tre!or * hyperre3e-ia

     H!pertoni tempert)re 14F o#)lr or in")#i+le #l

    ,ensiti.it! K4= n" ,pe#i#it!

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    MED%CAT%0N, THAT MAY C0NTR%(UTE T0 ,ER0T0N%N

    ,YNDR0MEAmp*etmines Anti"epressnts Antiemeti#s

    E#sts! ()spirone Meto#loprmi"e

    Detromp*etmine Lit*i)m 0n"nsetron

    Met*mp*etmine M0A%s Antimigrine Dr)gs

    ,i+)trimine SSR's Cr+mepine

    Anlgesi#s ,NR%s Ergot lloi"s

    C!#lo+enprine Tra4odone  TriptnsFentn!l TCAs @lproi# #i"

    Meperi"ine Mis#ellneo)s

     Trm"ol Co#ine

    +e-tro!ethorphan

    Lineoli"

    ,t Oo*nPs ?ort

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     TREATMENT

     ,top ll serotonergi# me"i#tions

     ,!mptom #ontrol

     H!pert*ermi8 eternl #ooling mes)res

     Agittion- m!o#lon)s8 +eno"iepines 9Lorepm 2 to 4 mg/g

    #*il"ren:

     C!pro*ept"ine 9serotonin ntgonist:

     Monitor 'or r*+"om!ol!sis- D%C- met+oli# #i"osis

     Mortlit! rte 1115=

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    E7AM 148 9AFTER AT%@A T &; HR EN8(ying in "ed 5uietly

     EYE,8 $)pils &mm- re#ti.e'nduci"le ocular clonus it* )pge n" lterl ge

     HENT8 ?NL

     C@/$ULM8 ?NL

     A(D8 ?NL

     NEUR08 Norml UE tone'ncreased (& tone. )7 "eats of induankle clonus "ilaterally. )* patellar +TRs.

     ,%N8ale.

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    E7AM K8 9AFTERCY$R0HE$TAD%NE: T &;4 HR 12 ($ 11K/61 RR 2

     >en8 Ae- Alert- NAD

     E!es8 $)pils & mm- re#ti.ecular clonus present "ut decrefro! yesterday.

     HENT8 ?NL

     C@/$ULM8 ?NL

     A(D8 ?NL

     NEUR08 Norml UE tone Mil"l!increased (& tone. $o aclonus. 8* patellar +TRs.

     ,in8 ?NL

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    FAL,E $0,%T%@E DRU>,CREEN

    piates hencyclidine

    Detromet*orp*n Detromet*orp*n

    Dip*en*!"rmine Dip*en*!"rmine

    Fl)oro3)inolones Detromp*etmine

    $opp! see"s n" oil Do!lmine

    Ri'mpin %+)pro'en

    )inine %miprmine

    etmine

    Meperi"ine

     T*iori"ine

     Trm"ol

    @enl'ine

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    REFERENCE,

    A+les- A et l $re.ention- Dignosis- n" Mngement o' ,eroto

    ,!n"rome Ameri#n Fmil! $*!si#in 21Q K1 9


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