Signaling via Ras

See: www.mpi-dortmund.mpg.de/imprs/Experiment3.pdf

Inhibitors of Farnesylation

From: Johnston, Lancet Oncol. 2001, 2, 18

N-Glycosylation

Glycosylation in the ER

From: http://glycores.ncifcrf.gov/

Glycan Diversity Generated in Golgi

Structure of N-Glycan

Imperiali, Curr. Opin. Chem. Biol. 1999, 3, 643

Pharmacological Inhibitors of Glycosylation

Glycosylation is Essential

D. S. Peal, unpublished results

Glycosylation Involved in Quality Control of Protein Folding

Notch Signaling Pathway

Blacklow, Curr. Opin. Chem. Biol. 2002, 6, 501

Notch Regulation by Glycosylation

Haltiwanger, Curr. Opin. Struct. Biol. 2002, 12, 593

Notch – Ligand Preference Influenced by Glycosylation