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 SILICON NANOTECHNOLOGIES FOR TRULYPERSONALIZED HEALTHCARE

RUDI CARTUYVELSSenior Vice President

Smart Systems & Energy Technologies  

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2© IMEC 2014

THE HEALTHCARE CHALLENGE

12M new cancerpatients each

year

350M Living withdiabetes

17M deaths fromheart diseaseeach year

36M Living withAlzheimer

’s 

132M Newbornbabies thisyear

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3© IMEC 2014

*= NON-COMMUNICABLE DISEASES ONLY. SOURCES. WHO,

WEFORUM

HEALTHCARE GLOBALLY: KEY DATA

Global Mortality Rate (56MM lives)

Other

23%

Neurology

Injury6%

Respiratory

7%

Infectious Diseases

18%Cancers

14%

CVD

30%

6.0

4.8

1.0

2.5

0.7

2.1

0.9

Cancers0.5

Diabetes

+106%

$13

Neurology

$6.3

0.5

0.3

Respiratory

CVD

2010 2030

Global Healthcare Expenditures* ($T)

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4© IMEC 2014 

BETTER

HEALTHCARE

hronic disease management

PREVENTIVE

HEALTH

Healthy lifestyle 

ENABLING THE NEXT HEALTHCARE

REVOLUTION

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5© IMEC 2014

MEDICALQUALITYDATA

IN 

CONSUMERHANDS

ULP Form Factor Affordabl

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6© IMEC 2014 

Applications

DataAnalytics

SystemsCircuits

& SensorsTechnology

IMEC’S WEARABLES R&D SCOPE

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Lowest power,

smallest & robust▸ Ultra-low power ECG &

actimetry measurement

▸ Bluetooth low energy

▸ Embedded artifact

reduction▸ Accurate rhythm analysis

▸ Activity tracking & energyexpenditure

▸ 30 days autonomy

IMEC ECG PATCH 

MULTISENSOR DATA FUSION

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Actimetry Application

Motion Artifact Suppression

Daily summaries

Online Feature extraction and

activity classification

Online personalized energy

expenditure estimation

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IMEC MULTI-SENSOR MIXED-SIGNAL SOC

World Lowest Power Sensor Hub for Bio-Medical ApplicationAnalog + DSP + Algorithms = 750uW in total

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IMEC & SAMSUNG DEVELOP SIMBAND PLATFORM

▸  ECG

▸  HR, HRV

▸  Blood Pressure

▸  Skin Temperature

▸  Actimetry

Based on imec’s ULP multisensor SOC & algorithms

http://www.samsung.com/us/globalinnovation/innovation_areas/

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NEXT GENERATION ECG: FLEXIBLE PATCH

10 grams

Monitors: Heart Rate,Motion,

skin contact quality

2 days autonomy on 15 mAh flex battery

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In vivoprobes

In vitrosystems

Cyto-metryMolecular

diagnostics

IMEC’S LIFE

SCIENCES

Si nanotechnology forpersonal diagnostics

& therapy

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10 mL blood80 billion red blood cells (~4-6 um)50 million platelets (~1-2 um)50 million white blood cells (~8-20 um)1-100 Circulating tumor cells (~8-24 um)

Need: powerful, low-cost, robust cell inspection toolthat can sort through millions of cells very quickly

adapted from M. Toner 13

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Granulocyte Red Blood cellLymphocyte

IMEC CELL SORTER

In flow lensfree imaging& classification of blood cells

sorting speed up to 1000 cells/s per channel

StroboscopicTracing of cells beingsorted

In flow reconstruction of a granulocyte flowing at 1mm/s

fluidic cell sorter on chip

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16© IMEC 2014

Microfluidic silicon platform Mixers, filters, microreactors

On-chip sample preparation From drop of blood to purified and amplified DNA

On-chip selective amplification Fast amplification (9 min) Multiplex amplification (more fragments in the same reactor)

On-chip detector

Dry chemistryA complexmicrofluidic Si chip

Integration of pumps and valve

with the Silicon chip

IMEC ON-CHIP DNA/RNADETECTION

DNAseparation

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http://www.diginfo.tv/v/13-0022-r-en.php

DigInfoTV Feature: DNA testing chip delivers results in one hour, paves

way for personalized drug treatments

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18© IMEC 2014

DISPOSABLE CAPILLARY PCR CHIPSchematic

Actual die Result

    L   a    d    d   e   r

    N   e   g   a   t    i   v   e

   c   o   n   t   r   o    l

    P   o   s    i   t    i   v   e

   c   o   n   t   r   o    l

    O   n  -   c    h    i   p

imec’s lab-on-chip PCRsystem using only capillary

forces to actuate fluids very compact PCR chip

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19© IMEC 2014 

EXAMPLE CAPILLARY COMPONENTSTrigger valve Tooth pump with controlled filling

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PERSONAL HEALTHCARE ENABLED BYSILICON NANOTECHNOLOGY

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IMEC’S HEALTHCARE R&D PARTNERS 

http://www.catharinaziekenhuis.nl/http://www.philips.nl/http://www.jnj.com/http://spauldingrehab.org/

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