- 1. SILKPEEL SCIENCE e med, Inc. Confidential. For Internal Use
Only
2. Table of Contents
- Overview of the SilkPeel Device
- Overview ofSilkPeel Topical Solutions
- A Quick and Easy Clinical Procedure
- Benefit to the Clinical Practice
- Comparison to Other Clinical Procedures
Confidential. For Internal Use Only 3. Executive Summary
- SilkPeel, is a breakthrough system that combines precision
non-invasive dermabrasion with Dermalinfusion to improve and
revitalize the skin.The SilkPeel device provides a multi-functional
alternative to conventional microdermabrasion that provides faster
visible improvements to skin that will improve patient retention
and help build our physicians practices.SilkPeel procedures are
highly customizable to address various aesthetic conditions and can
be safely and synergistically combined with other
dermatologicprocedures.
Confidential. For Internal Use Only 4. Overview of silkpeel
device
Confidential. For Internal Use Only 5. What is the SilkPeel?
- SilkPeel, is a breakthrough system that combines precision
non-invasivedermabrasionwithDermalinfusionto improve and revitalize
the skin.
Confidential. For Internal Use Only 6. What is Dermabrasion?
Confidential. For Internal Use Only Stratum corneum Stratum lucidum
Stratum granulosum Stratum spinosum Stratum basale The SilkPeel
diamond-head probe removes the top-most portion of the epidermis
called the stratum corneum. This isdermabrasion .Epidermis 7.
Benefits of Dermabrasion
- Normalization of the stratum corneum 1
- Thickening of the epidermis and dermis 1
- New deposition of collagen and elastic fibers 1
- 1-Freedman, B. M., Rueda-Pedraza, E. and Waddell, S. P. The
epidermal and dermal changes associated withmicrodermabrasion.
Dermatol Surg 2001;27:1031-3; discussion 1033-4.
Confidential. For Internal Use Only 8. What is Dermalinfusion?
Confidential. For Internal Use Only Stratum corneum Stratum lucidum
Stratum granulosum Stratum spinosum Stratum basale SilkPeel
Solutions are simultaneously infused into the viable epidermis.
This isdermalinfusion .Epidermis 9. Why combine dermabrasion with
dermalinfusion
Confidential. For Internal Use Only Abraded Skin Stratum corneum
Stratum lucidum Stratum spinosum Stratum basale Stratum granulosum
Most topicals never penetrate past the stratum corneum Removing the
stratum corneum allows penetration of topicals into the viable
epidermis 10. SilkPeel Versus Traditional Microdermabrasion
Confidential. For Internal Use Only Category SilkPeel
Microdermabrasion Abrasive Source Diamond Head Wand Aluminum Oxide
Crystals Dermalinfusion Delivered under pneumatic pressure -
Tailored Treatments Exfoliation + Dermalinfusion of solutions
specific for: -Dry Skin -Hyperpigmentation -Photoaging -Acne
Exfoliation used for all indications Validated Cleaning /
Disinfecting Method Yes No 11. OVERVIEW OF Silkpeel Topical
solutions
Confidential. For Internal Use Only 12. Conditions Addressed by
SilkPeel Solutions Confidential. For Internal Use Only Condition
SilkPeel Solution Dry Skin (Xerosis) Hydrating Serum
Hyperpigmentation Brightening Serum Photoaging Vitamin C Serum Acne
Clarifying Serum 13. Target Skin Layers for SilkPeel Solutions
Confidential. For Internal Use Only Moisturizing (Epidermis)
Clarifying (Hair follicle) Brightening (Melanocytes) Vitamin C
(Epidermis / Dermis) 14.
- Epidermis- The epidermis is the outermost layer of the skin
that acts as the body's major barrier against the external
environment. Dry skin occurs if the epidermis becomes dehydrated.
This is also the major site of free-radical damage caused by
chronic exposure to sunlight.
- Dermis- The dermis is a layer of skin between the epidermis and
subcutaneous tissues composed of collagen, elastic fibers and
extrafibrillar matrix.Production of collagen slows as the skin ages
which contributes to the formation of wrinkles.
- Hair Follicle The part of the skin that grows hair. This is the
primary site of acne development.
- Melanocyte Melanin producing cells located in the bottom most
layer (stratum basale) of the epidermis. Melanocytes can
overproduce melanin thus causing hyperpigmentation in skin.
Review of Skin Anatomy Confidential. For Internal Use Only 15.
Dry Skin (Xerosis)
- Symptoms include a feeling of skin tightness, especially after
showering, bathing or swimming, skin that appears shrunken or
dehydrated, skin that feels and looks rough rather than smooth,
itching (pruritus) that sometimes may be intense, slight to severe
flaking, scaling or peeling, fine lines or cracks, redness and deep
fissures that may bleed in severe cases
- Causesinclude weather, heating, air conditioning, hot
baths/showers, harsh soaps/detergents, sun exposure, psoriasis or
thyroid disorders.
- Source : Mayo Foundation for Medical Education and Research
(MayoClinic.com)
Confidential. For Internal Use Only 16. Images of Dry Skin
Confidential. For Internal Use Only Source : Procter & Gamble
17. SilkPeel Dermalinfusion Hydrating Formula: Key Ingredients for
improvement of dry skin Confidential. For Internal Use Only INCI
Function Glycerin A naturally-derived humectant which helps retain
moisture. Sodium Hyaluronate A naturally-derived mucopolysaccharide
that is a component of the Natural Moisturizing Factor (NMF), the
water-soluble compounds responsible for the wettability,
water-holding and absorbing powers of the skin.Provides exceptional
moisturization, lubricity, luxurious slip and a remarkable
afterfeel to the skin. Aloe Barbadensis Leaf Extract An extract
from the leaves of Aloe barbadensis Miller. It provides remarkable
conditioning and moisturizing properties to help calm and refresh
skin. Allantoin An active skin protectant used for its healing,
softening, and moisturizing properties. 18. Hyperpigmentation
- Focal Hyperpigmentationis most often postinflammatory in
nature, occurring after injury (eg, cuts and burns) or other causes
of inflammation (eg, acne, lupus).
- Melasmaconsists of dark brown, sharply marginated, roughly
symmetric patches of hyperpigmentation on the face. It occurs
primarily in pregnant women and in women taking oral
contraceptives.
- Lentigines(singular: lentigo) are flat, tan to brown oval
spots. They are commonly due to chronic sun exposure (solar
lentigines; sometimes called liver spots).
- Source : The Merck Manual (www.merck.com)
Confidential. For Internal Use Only 19. Images of
Hyperpigmentation Confidential. For Internal Use Only Courtesy of
Reliant Technologies Source : www.clinic-skin.com 20. Silkpeel
Dermalinfusion Brightening Formula: Key Ingredients for the
improvement of hyperpigmentation Confidential. For Internal Use
Only INCI Function Glycolic Acid Normalizes hyperkeratinization
(exfoliates over-thickened skin) and increases viable epidermal
thickness and dermal glycosaminoglycans content Morus Alba Bark
Extract An extract of the root of the mulberry which contains skin
lightening properties Kojic Acid Effective for inhibiting melanin
productionArbutin An effective skin whitening by inhibition of
melanin synthesis. 21. Photoaging
- Among other things, chronic exposure to sunlight triggers the
overproduction of reactive oxygen species (free radicals) that
cause cellular damage which is partially responsible for overall
photoaging of skin.
- Vitamin C (L-ascorbic acid) is the main water-soluble
nonenzymatic antioxidant in the human body.Vit C interacts with a
wide variety of free radicals intracellularly (inside skin cells)
and forms a front-line extracellular (outside of skin cells)
defense against free radicals in plasma.
- Source : Colven, R. M. and Pinnell, S. R. Topical vitamin C in
aging. Clin Dermatol 1996;14:227-34.
Confidential. For Internal Use Only 22. Images of Photoaged Skin
Confidential. For Internal Use Only Source : www.about.com Source :
www.no2tanning.info 23. Vitamin C Serum: Key Ingredients for the
improvement of photoagingConfidential. For Internal Use Only
Topical application of an antioxidant serum, post-treatment,
enhances the effect of microdermabrasion 1 . Reference :
1-Freedman, B. M. Topical antioxidant application enhances the
effects of facial microdermabrasion. J DermatologTreat 2008:1-6.
INCI Function Sodium Ascorbyl Phosphate Sodium ascorbyl phosphate
is a stable derivative of L-ascorbic acid (vitamin C). It has been
demonstrated that addition of sodium ascorbyl phosphate
synergistically improves sunscreen photoprotection against
UV-induced oxygen species . Additional benefits of sodium ascorbyl
phosphate include anti-acne utility, stimulation of collagen
synthesis and improvement in the appearance of
hyperpigmentation.Tocopheryl Acetate Vitamin E is the major
naturally occurring lipid-soluble antioxidant protecting skin from
the adverse effects of oxidative stress including photoaging (sun
damage).Vitis Vinifera (Grape) Seed Extract Contains
proanthocyanidins, which are very potent antioxidants, helpful for
diminishing the suns damaging effects and lessening free-radical
damage. 24. Acne
- Acne vulgaris(acne) is the formation of comedones, papules,
pustules, nodules, and/or cysts mainly on facial skin. Acne occurs
when pilosebaceous units (hair follicles and their accompanying
sebaceous gland) become obstructed with plugs of sebum and
desquamated keratinocytes, then colonized and sometimes infected
with the normal skin anaerobePropionibacterium acnes .
Manifestations differ depending on whether P. acnes stimulates
inflammation in the follicle; thus acne can be noninflammatory or
inflammatory.
- Source : The Merck Manual (www.merck.com)
Confidential. For Internal Use Only 25. Image of Acne
Confidential. For Internal Use Only Source :
www.dermatology.svhm.org.au 26. Clarifying Serum: Key Ingredients
for the improvement of acne Confidential. For Internal Use Only
INCI Function Salicylic Acid Referred to as beta hydroxy acid
(BHA), it is a multifunctional ingredient that addresses many of
the systemic causes of blemishes. For decades dermatologists have
been prescribing salicylic acid as an exceedingly effective
keratolytic (exfoliant), but it also is an anti-irritant. In
concentrations of 0.5% to 2%, it can exfoliate the surface of skin,
much like AHAs. In addition, BHA has the ability to penetrate into
the pore (AHAs do not), and thus can exfoliate inside the pore as
well as on the surface of the skin, which makes it effective for
reducing blemishes, including blackheads and whiteheads. 27.
Clinical Efficacy Confidential. For Internal Use Only 28. Comedone
Extraction Serum: New serum to be used for removal of comedones
(black heads)
- A comedone extraction serum is currently being developed for
the removal of black heads.
- Comedone extraction is achieved with the SilkPeel by combining
a high vacuum setting with minimal abrasion and simultaneous
dermalinfusion of the soon to be launched Comedone Extraction
Serum.
Confidential. For Internal Use Only 29. A quick and easy
clinical procedure
Confidential. For Internal Use Only 30. Lunch-Time
Rejuvenation
- A typical SilkPeel treatment will last about 20 minutes.
- No downtime for the patient
- Patient may feel a mild exfoliation and tightening that leaves
the skin feeling healthy and smooth.
- Skin may have a warm, pinkish glow that will usually fade in
about 30 minutes, leaving skin looking healthy and renewed.
Confidential. For Internal Use Only 31. SilkPeel Procedure
- Summary of SilkPeel protocol
Confidential. For Internal Use Only 32. Benefit to the clinical
practice
Confidential. For Internal Use Only 33. Excellent Patient
Satisfaction Confidential. For Internal Use Only No downtime or
ugly phase Skin resurfacing w/ dermalinfusion yields faster results
Improves patient retention Noninvasive Procedure Faster visible
improvement in skin Enhanced patient satisfaction 34. Simple and
Safe Clinical Procedure
- SilkPeel procedure can be performed by a fully trained
physician or aesthetician.
- The risks of traditional microdermabrasion are eliminated by
the SilkPeel's crystal-free technology and patients experience
little to no discomfort.
Confidential. For Internal Use Only 35. Improve Outcome of
Existing Procedures
- SilkPeel enhances the outcome of the followingtreatments:
-
- Intense Pulsed Light Therapy
-
- Topical Anti-Aging Regimens
Confidential. For Internal Use Only 36. Adds Value to the
Physicians Practice Confidential. For Internal Use Only 37.
SilkPeel FAQs
- QUESTION : What is the benefit of dermalinfusion? Why not just
apply a serum to the skin after traditional microdermabrasion?
- ANSWER : Dermalinfusion delivers topical solutions more
efficiently than topical application due to the use of pneumatic
pressure which helps drive SilkPeel serums deeper into the
skin.
- QUESTION : Does the vacuum inhibit the SIlkPeel from
effectively infusing serums?
- ANSWER : No. The vacuum merely suctions excess solution on
either side of the diamond head that is not absorbed into the
skin.
Confidential. For Internal Use Only 38. SilkPeel FAQs
- QUESTION : How can SilkPeel improve the outcome of IPL
treatments?
- ANSWER : When used as a pretreatment, SIlkPeel improves the
penetration of light into the skin.
- QUESTION : How can SilkPeel improve the outcome of Fraxel
procedures?
- ANSWER : The SilkPeel can be used to remove plaques and hydrate
skin 2 weeks post-Fraxel treatment in order to promote enhanced
repair and rejuventation of skin.
Confidential. For Internal Use Only 39. SilkPeel FAQs
- QUESTION : How do you clean and disinfect the SilkPeel?
- ANSWER : Unlike traditional microdermabrasion devices, the
SilkPeel is the only dermalinfusion/microdermabrasion system with a
validated cleaning and disinfecting method.
- QUESTION : Why doesnt e med offer oxygen infusion with the
SilkPeel?
- ANSWER : One of the central causes of photodamage is oxidation
caused by oxygen free radicals. Free radicals are generated from
oxygen when skin is moderately exposed to sunlight.
Confidential. For Internal Use Only 40. SilkPeel FAQs
- QUESTION : Why does the Vitamin C Dermalinfusion Serum use a
vitamin C derivative rather than vitamin C?
- ANSWER : The vitamin C derivative (sodium ascorbyl phosphate)
is considerably more stable than vitamin C (L-ascorbic acid) in
aqueous formulas. Besides being a good antioxidant, this derivative
also improves acne and hyperpigmentation
- QUESTION : Why do the SilkPeel serums use parabens? Arent
parabens bad for you?
- ANSWER : Parabens remain the most effective antimicrobial
preservatives for aqueous formulations. Both U.S. (FDA &
American Council on Science and Health) and European Health
agencies (via European Cosmetic Directive) consider parabens safe
for human use.
Confidential. For Internal Use Only