Silver-haired Bat(Lasionycteris noctivagans)

• Vector of cryptic rabies virus

• 1990-2002: ~70% of 33 reported human rabies cases in the US

• Only 2 cases had a history of bat bite

Plant System For High-Yield Production of Recombinant Subunit Vaccines

Safety Cost-efficiency Easy scale-up Proper glycosylation Suitable for developing

countries Possible direct delivery

Vaccine Production in Plants

RABIES VIRUS NEUTRALIZING TITERS OF HUMAN SERA

010002000

30004000

50006000

70008000

900010000

1 2 3 4 5 6 7 8

Pre-IPre-BPost-B

CONTROL EXPERIMENTAL

BIOMEDICALS FOR DISEASE PROPHYLAXIS AND TREATMENT EXPRESSED IN PLANTS AT THE BIOTECHNOLOGY FOUNDATION LABORATORIES

DISEASES PLANT VACCINE Antibody

Severe AcuteRespiratory Syndrome (SARS)

Anthrax

Respiratory Syncytial Virus (RSV)

Smallpox

Diphtheria, Pertussis, Tetanus (DPT)

Rabies

HIV

Avian Influenza

Hepatitis B

Colorectal and Breast Cancer

Tobacco Tomato

Cauliflower

TobaccoTomatoSpinach

TobaccoSwiss Chard

CollardSwiss Chard

CarrotTobacco

SpinachCollardTobacco

Spinach

Barley

LettuceCauliflower

Tobacco

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(recently initiated)

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COMPARATIVE COSTS OF ANTI-RABIES ANTIBODIES

  COMPANY PRODUCT PRODUCT DESCRIPTION PRODUCT PRICENAME SOURCE

Bayer BayRab Human human anti-Rabies 1500 iu $1,125.Donors immunoglobulins

 

Aventis IMOGAM Human anti-Rabies 1500 iu $ 847. Rabies-HT Donors immunoglobulins wholesale (10-18% protein) price

 

AbCam ab10014 Mouse monoclonal mouse 100 µg $ 250.Cells antibodies

Biotechnology MAb57 Tobacco monoclonal mouse 100 µg $ 0.5 -$1.Foundation, Inc.