SIMSAM EARLY LIFEInterdisciplinary research on early life exposure and health

Coordinator: Anna Rignell-Hydbom Co-coordinator Jonas Björk

Division of Occupational and Environmental Medicine, Faculty of Medicine

Centre for Economic Demography, Lund University School of Economicsand Management

Department of Landscape Architecture, Planning and Management, Swedish University of Agricultural Sciences

• More than 100 publications based on registry, survey and biobank data co-authored by SIMSAM Lund participants.

• In association to the programme 13 PhD students have defended their thesis.

• Fourteen new PhD students have started their education within SIMSAM Lund

• Post-docs have been recruited

• Several courses, seminars and workshops

• National and international collaborations

SIMSAM Lund

SIMSAM Lund – example of articles

Associations between gestational complications; gestational diabetes and preeclampsia and air pollution.

Malmqvist E, Jakobsson K, Tinnerberg H, Rignell-Hydbom A, Rylander L. Environ Health Perspect. 2013;121:488-493

Background

A number of studies have shown associations between maternal air pollution exposure and adverse birth outcomes.

However; limited information exist for exposure to air pollution and pregnancy complications

81,110 women (singleton births) 1999-2005 were linked to individually assessed nitrogen oxides and traffic intensity.

1 599 cases of gestational diabetes, 2 370 cases of preeclampsia

Emission and meteorological National Road database

data

Results

NOx (µg/m3) OR Gestational diabetes

OR Preeclampsia

Quartile 1(2.5-9)

1.00 1.00

Quartile 2(9-14)

1.19 (0.99-1.44) 1.28 (1.13-1.46)

Quartile 3 (14-23)

1.52 (1.28-1.82) 1.33 (1.17-1.52)

Quartile 4(over 23)

1.69 (1.41-2.03) 1.51 (1.32-1.73)

Maternal smoking during pregnancy and daughters’risk of gestational diabetes and obesity

Mattsson K, Källén K, Longnecker MP, Rignell-Hydbom A, Rylander L.

Diabetologia 2013;56:1689-95.

Background

A study from Norway (the MoBa cohort) showedsignificant associations

However:- Relatively high fraction of non-participants- Smoking data collected retrospectively

Study design

Inclusion criteria:

- Women born 1982 or later who have had at least one child of their own.

- Complete data on relevant variables (smoking, BMI, birth weight etc)

- Total of 54 012 women for the final analyses.

Gestational diabetesCrude OR (95% CI) Adj OR (95% CI)

Non-smokers (ref)

1 1

1-9 cig/dag 1.73 (1.33, 2.26) 1.62 (1.24, 2.13)

>9 cig/dag 1.68 (1.25, 2.27) 1.52 (1.12, 2.06)

Non-smokers (ref) 1 1

1-9 cig/dag 1.40 (1.32, 1.48) 1.36 (1.28, 1.44)

>9 cig/dag 1.65 (1.54, 1.75) 1.58 (1.48, 1.68)

Obesitas (BMI>30 kg/m2)

Cognitive reserve and dementia – Dekhtyar, S., Wang, H-X., Scott, K., Goodman, A., Koupil, I., Herlitz,

A.• Dementia is a debilitating

process characterized by the loss of memory and cognitive function in old age

• Variations exist in the extent of neuropathology required for dementia diagnoses

• To explain the disjunction between the extent of brain damage and its clinical manifestation – RESERVE was suggested

• Brain reserve: anatomical features of brain structure help tolerate more dementia

• Cognitive reserve: innate intelligence and stimulating life experiences make brain networks more efficient

• Cognitive reserve is measured by education or occupational complexity

• Educational and occupational attainment have social and cognitive prerequisites

• Early cognitive ability could be a better instrument for cognitive reserve

• A life-course model of cognitive reserve in dementia is yet to be tested

SIMSAM Lund – Courses and seminars

• New courses on advanced topics

– Family-based designs (Paul Lichtenstein, Johan Hallqvist, Brian d’Onofrio)

– Developmental psychology in a life course perspective (Elia Psuoni, Ilona Kuopil)

– Bias in observational studies – what can go wrong in Epidemiology? (Jonas Björk)

– Collaboration with research schools at the FAS-centre MetaLund and CED at Lund University

• Open seminars on methodological issues regularly

– In collaboration with EpiHealth and FoU-centrum Skåne

SIMSAM Lund – Open seminars• Registry-based randomized trials

• Propensity scores

• Introduction to DAGs

• Analysis of cross-sectional data

• Rasch analysis

• Bayesian methods

• Qualitative methods

• Individual vs. population risk

• Multiple imputation

• Validation of the Cox model

• Age-Period-Cohort modeling

• ...

Extensive and highly accessed collection of

presentations available on-line

EpiHealthLund

Uppsala

Centre forEconomic

DemographyLund

MetaLundLU & LTH

SIMSAMnetwork

• Phd student conferences

• Courses

• Interdisciplinary projects

Network for PhD-students at SIMSAM Lund

SIMSAM Lund – Cohort inventory

• Joint initiative with EpiHealth and FoU-centrum Skåne

• Close cooperation with SND

SIMSAM Lund – Cohort inventory (cont.)

SIMSAM Lund – additional infrastructure initiatives warranted

• Still too hard for researchers outside the “register-based research clusters” to use registry data

– Ethics and legislation

– Study design

– Data access

– Data management

– Security issues

– ...

Consulting and

data managementfacilities

Virtualand physical

meeting place

Common tools, routines and

technical platforms

Arena fornew

collaborations

Knowledge transferCoursesSeminars

Workshops

SIMSAM Lund

Centre for interdisciplinary

research based onregistries and

biobanks

Tack Anna !!för det fantastiska arbete du gjort för oss dessa år