SCIENTIFIC PROGRAM CONGRESS PRESIDENTS:................................................................................... - Lorenzo Borgognoni, Division of Plastic and Reconstructive Surgery, Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit, S.M. Annunziata Hospital, Florence, Italy..................................................... - Nicola Pimpinelli, Division of Dermatology, Dept. Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy. HOT TOPICS IN MELANOMA & NON-MELANOMA. SKIN CANCER 2018 Florence, April 12 14 , 2018 Convitto della Calza th th With an unrestricted grant by
Lorenzo Borgognoni, Division of Plastic and Reconstructive Surgery, Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit, S.M. Annunziata Hospital, Florence, Italy..................................................... -
Nicola Pimpinelli, Division of Dermatology, Dept. Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy.
HOT TOPICS IN MELANOMA & NON-MELANOMA .
SKIN CANCER 2018Florence, April 12 14 , 2018Convitto della Calza
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With an unrestricted grant by
Under the Auspices of
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018
SIDCO
Società Italiana di Dermatologia Chirurgica ed Oncologica
DCMTDIPARTIMENTO DICHIRURGIA E MEDICINATRASLAZIONALE
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SIDeMaSTSocietà Italiana di Dermatologia
Dear Friends and Colleagues,
It is a great pleasure to wel-come you in Florence to the 2018 edition of the ‘Hot Topics’ in Melanoma and Non-M e l a n o m a S k i n C a n ce r (NMSC). From the previous edition in 2015, great news have followed in the rapidly evolving field of cutaneuos oncology. New, effective drugs have been increasingly used in practice, and in the mean time the close integration among prevention, early diagnosis, surgical and medical therapies has become even more important in the fight against skin cancer.
During the Congress you will have the opportunity to hear state-of-the-art presentations given by leading experts in the field of skin cancer. Key opinion leaders in Melanoma and NMSC are invited to give an overview of the most recent advances in the pathogenesis, diagnosis, and treatment, and of the latest clinical trial results and new drugs development.
We are confident you all will appreciate the meeting, and look forward to welcoming you in Florence!
Lorenzo Borgognoni Nicola Pimpinelli
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
Borgognoni LorenzoDept. Plastic and Reconstructive SurgeryMelanoma & Skin Cancer UnitAUSL Toscana Centro Florence, Italy
Pimpinelli NicolaDiv. Dermatology Dept. Surgery and Translational Medicine University of Florence Florence, Italy
Zinzani Pier Luigi Inst. Hematology “L. e A. Seràgnoli”University of BolognaBologna, Italy
Registration
Symposium I: POSTER PRESENTATIONSChairs: G. Gerlini S. Sestini (Florence, Italy) (Florence, Italy),
S. Mancini (Cesena, Italy): Incidence and mortality of melanoma in Europe - the ECIS tool
S. Mancini (Cesena, Italy): Malignant melanoma incidence trends: preliminary results of age-period-cohort analysis in Romagna, region of Italy
S. Mancini (Cesena, Italy): Melanoma survival according to Cox model versus classification and regression trees analysis: a registry-based study
G. Bagnoni (Livorno, Italy): Epidemiology of melanoma in Livorno between 2006 and 2016 and evaluation of risk factors for the positivity of lymph nodes in pT1b-pT3 groups
A. Ravaioli (Ravenna, Italy): What has changed for thin melanoma moving from TNM 7th to TNM 8th?
E. Antoniazzi (Bologna, Italy) Animal-type Melanoma. A case report
H. Kocic (Nis, Serbia): Multiple blue-black lesions on the face of the 58-year old patient.
C. Mazzatenta (Lucca, Italy): Imiquimod treatment of lentigo maligna melanoma
C. Ottanelli (Florence, Italy): Predective prognostic value of lactate dehydrogenase (LDH) variations during treatment in advanced (stage IIIc-IV) melanoma: preliminary results of a monocentric observational study
S. Gunnella (Florence, Italy): Target Therapy with Dabrafenib e Trametinib "beyond progression" associated with electrochemotherapy (ECT) and Zoledronic Acid in a patient with BRAF mutated metastatic melanoma.
R. Colucci (Florence, Italy): Bacterial and fungal gut microbiota composition in melanoma patients: preliminary results
S. Peppicelli (Florence, Italy): Aspects of Melanoma cells adapted to a chronic acidosis relevant for therapy
A. Biagioni (Florence, Italy): uPAR gene knockout mediated by CRISPR/Cas9 in Melanoma: a pivotal role for a "sociable" receptor
J. Ruzzolini (Florence, Italy): Oleuropein potentiates the cytotoxic activity of Dacarbazine against melanoma cells
F. Margheri (Florence, Italy): uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells
E. Andreucci (Florence, Italy): Carbonic anhydrase IX targeting in melanoma treatment: the role of acidic tumor microenvironment.
I. Lastrucci (Florence, Italy): Treatment and outcome of basal cell carcinoma in the setting of dermato-oncology clinic
A. M. D'Erme (Livorno, Italy): Use of vismodegib in advanced basal cell carcinoma: the experience of Livorno
2.30 pm - 3.30 pm
3.30 pm - 5.30 pm
thThursday - April 12 , 2018
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
A. Lamberti (Siena, Italy): Vismodegib: a useful treatment for Gorlin-Goltz Syndrome
I. Lastrucci (Florence, Italy): Dermatofibrosarcoma Protuberans secondary to a tattoo? Case report and review of literature.
A. M. D'Erme (Livorno, Italy): A clinical, dermoscopic and histological challenge: the pigmented mammary Paget’s disease
P. Vitiello (Naples, Italy): Diffuse large B cell lymphoma "non-germinal centre type". A case report
S. Gunnella (Florence, Italy): Primary cutaneous CD8+ CD30+ lymphoproliferative disorder in patient with CD4 acquired immunodeficiency
I. Lastrucci (Florence, Italy): Indolent CD8-positive lymphoid proliferation of acral sites
Symposium II «UGO BOTTONI»SELECTED ORAL COMMUNICATIONSChair: S. Calvieri (Rome, Italy) E. N. Gangemi (Torino, Italy): Complex reconstruction in dermatosurgery:
our experience
R. Villani (Bologna, Italy): Reconstruction of upper palpebral fissure
G. Damiani (Milan, Italy): Squamous cell carcinoma of the scalp and its treatment. Role of radiation therapy
D. Russo (Naples, Italy): Role of carbonic anidrase IX in the neoplastic progression of basal cell carcinoma
A. Pileri (Bologna, Italy): Primary cutaneous Rosai-Dorfmann Disease: diagnostic and therapeutic aspects
V. Grandi (London, United Kingdom): T-cell receptor CDR3 region deep sequencing with padlock probes as a diagnostic tool in T-cell malignancies
F. Bianchini (Florence, Italy): Selective targeting of melanoma cells and efficient cellular internalization using RGD-functionalized gold
M. Colombino (Sassari, Italy): Sinonasal mucosal melanomas from the Southern Italian population are mutated in the BRAF gene
A. Laurenzana (Florence, Italy): Therapeutic strategies to overcome Vemurafenib acquired resistance in melanoma cells
OPENING PLENARY LECTUREChairs: L. Borgognoni (Florence, Italy), N. Pimpinelli (Florence, Italy)
Causative factors and chance events in the pathogenesis of cancerLucio Luzzatto (Dar-es-Salaam, Tanzania)
Welcome reception
5.30 pm - 7.00 pm
7.00 pm - 7.30 pm
7.30 pm
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
Welcome address
Keynote LectureChair: N. Pimpinelli (Florence, Italy)
Pathogenesis of NMSC and influence on treatmentChairs: P.G. Calzavara-Pinton (Brescia, Italy), F. Ayala (Naples, Italy)
Session 1Non-Melanoma Skin Cancer (NMSC): pathogenesis, diagnosis and topical treatmentChairs: P.G. Calzavara-Pinton (Brescia, Italy), F. Ayala (Naples, Italy)
1. Risk of post-transplantation NMSC: an update L. Naldi (Bergamo and Vicenza, Italy)
2. The role of nicotinamide in kidney transplant recipients A. Parodi (Genua, Italy)
3. Topical treatment of NMSC: the evolving scenario L. Zichichi (Trapani, Italy)
4. PhotoDynamic Therapy of NMSC: new approaches and indications S. Piaserico (Padua, Italy)
5. Treatment algorithm in NMSC G. Micali (Catania, Italy)
6. Discussion
Coffee break-
Keynote LectureChair: L. Borgognoni (Florence, Italy)
Checkpoint blockade in NMSC D. Schadendorf (Essen, Germany)-
Session 2NMSC: surgical and systemic treatmentChairs: M. Fimiani (Siena, Italy), R. Gelli (Florence, Italy)-
1. Defining high risk NMSC M. Simonacci (Macerata, Italy)-
2. Reconstructive surgery of NMSC F. Bassetto (Padua, Italy)-
3. Perforator flaps for skin cancer reconstruction of the head B. Brunetti , P. Persichetti (Rome, Italy) (Rome, Italy)-
4. Merkel cell carcinoma: new insights in surgical and systemic treatment A. Maurichi , S. Pusceddu (Milan, Italy) (Milan, Italy)-
5. Systemic treatment of Kaposi’s sarcoma: when and how L. Brambilla (Milan, Italy) -
6. Discussion
Lunch
8.30 am - 8.45 am
8.45 am - 9.15 am
9.15 am - 10.45 am
10.45 am - 11.00 am
11.00 am - 11.30 am
11.30 am - 1.00 pm
1.00 pm - 2.00 pm
thFriday - April 13 , 2018
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
8.00 am - 8.30 am Opening secretariat
Keynote LectureChair: S. Pileri (Milan, Italy)
Diagnosis of cutaneous lymphoma: tools and rules L. Cerroni (Graz, Austria)
Session 3Cutaneous Lymphoma: update in diagnosis and pathogenesisChairs: G. Ferrara (Benevento and Macerata, Italy), L. Leoncini (Siena, Italy)
1. Cutaneous T-cell Lymphoma M. Santucci (Florence, Italy)-
2. Cutaneous B-Cell Lymphoma M. Paulli (Pavia, Italy)-
3. Rare entities of cutaneous lymphoma E. Berti (Milan, Italy)
Keynote LectureChair: E. Berti (Milan, Italy)
Pathogenesis of cutaneous lymphoma: focus on the most clinically relevant issuesM.H. Vermeer (Leiden, The Netherlands) -
4. Cellular microenvironment and progression of Mycosis Fungoides A. Pileri (Bologna and Florence, Italy)-Coffee Break -
Keynote LectureChair: N. Pimpinelli (Florence, Italy)
Treatment of cutaneous lymphoma: a stage-based algorithm Y.H. Kim (Stanford, USA)
Session 4Cutaneous Lymphoma: current treatment and evolving trendsChairs: S. Rupoli (Ancona, Italy), P.L. Zinzani (Bologna, Italy)
1. Skin-directed treatment in cutaneous T-cell lymphoma M. Bagot (Paris, France)
2. Phototherapy of early Mycosis Fungoides: the position of the Cutaneous Lymphoma Task Force of the Italian Lymphoma Foundation V. Grandi (Florence, Italy)
3. Total skin electron beam radiotherapy of cutaneous T-cell lymphoma: improving efficacy while reducing toxicity G. Simontacchi (Florence, Italy) -
4. Patterns of care in advanced cutaneous T-cell lymphoma P. Quaglino (Turin, Italy)- 5. Discussion
2.00 pm - 2.30 pm
2.30 pm - 4.00 pm
4.15 pm - 4.45 pm
4.45 pm - 6.00 pm
4.00 pm - 4.15 pm
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
Opening secretariat
Keynote LectureChair: E. Crocetti (Florence, Italy)
Worldwide Cancer Registry data on Melanoma and NMSC: incidence, mortality and trends F. Bray (Lyon, France)
Session 5Epidemiology, Screening and Diagnosis of Cutaneous MelanomaChairs: A. Offidani (Ancona, Italy), C. D’Aniello (Siena, Italy)
1. Skin cancer screening and secondary prevention campaigns E. Crocetti (Florence, Italy)
2. Dermoscopy, confocal reflectance microscopy and sequential follow-up of pigmented lesions I. Stanganelli (Parma and Meldola, Italy)
3. Dermoscopic diagnosis of amelanotic/hypomelanotic melanoma M.A. Pizzichetta (Aviano, Italy)
4. Genetic markers of prognostic outcome G. Palmieri (Sassari, Italy)
5. Fishing for answers in precision melanoma medicine M. Fazio (Boston, USA)
6. Discussion
Coffee break
Keynote LectureChair: L. Borgognoni (Florence, Italy)
Surgery, sentinel node biopsy and lymphadenectomy in melanoma: evolution of a new treatment paradigm V.K. Sondak (Tampa, USA)
Session 6Surgery of Melanoma: update of an evergreenChairs: C. Caracò (Naples, Italy), A. Cordova (Palermo, Italy)
1. The importance of quality control program in melanoma treatment C.R. Rossi (Padua, Italy)
2. Sentinel biopsy in thick melanoma: is it worthwhile? S. Sestini (Florence, Italy)
3. The role of surgery in advanced melanoma: when alone, when combined, when useless ? N. Mozzillo (Naples, Italy) -
4. Melanocytic tumors of uncertain biologic potential: what are they, and how to manage ? A. Maurichi (Milan, Italy)
5. The AJCC melanoma staging system 8th edition: what changed in clinical practice ? A. Testori (Milan, Italy)
6. Discussion
8.30 am - 9.00 am
9.00 am - 10.30 am
10.30 am - 11.00 am
11.00 am - 11.30 am
11.30 am - 1.00 pm
thSaturday - April 14 , 2018
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
8.00 am - 8.30 am
Lunch
Keynote LectureChair: S. Moretti (Florence, Italy)
B7-H3, an attractive target of antibody based immunotherapy of solid tumors S. Ferrone (Boston, USA)
Session 7Medical treatment of advanced melanoma: a rapidly changing scenarioChairs: E. Mini (Florence, Italy), S. Pino (Florence, Italy), R. Marconcini (Pisa, Italy)-
1. Molecular testing in melanoma: an update D. Massi (Florence, Italy)
2. Update in adjuvant melanoma treatments and trials P. Queirolo (Genua, Italy)
3. Adjuvant melanoma treatment with beta-blockers: facts and future directions V. De Giorgi (Florence, Italy)
4. Target therapy of melanoma: where are we today ? M. Del Vecchio (Milan, Italy)
5. Immunotherapy: from a concept to a well-established reality A.M. Di Giacomo, M. Maio (Siena, Italy)
6. Immunomodulating properties of target therapies M. Mandalà (Bergamo, Italy)
7. Stable complete response after target or immune therapy in stage IV: stop or continue treatment? V. Chiarion-Sileni (Padua, Italy)
8. Electrochemotherapy: indications, results and lessons from biology G. Gerlini (Florence, Italy)
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
1.00 pm - 2.00 pm
General information
Meeting venueThe venue for the Meeting will be CONVITTO DELLA CALZA, Piazza della calza nr. 6 – Florence, ItalyRoom PONTE VECCHIO
Secretariat during the MeetingThe Secretariat will be open at the following times:
thThursday, April 12 , from 1.30 p.m. to 7.30 p.m.thFriday, April 13 , from 7.30 a.m. to 6.00 p.m.
thSaturday, April 14 from 7.30 a.m. to 5.00 p.m.
Official languageThe official language of the Meeting will be English.Simultaneous translation will not be provided.
Italian ECM AccreditationThe Event entitled HOT TOPICS IN MELANOMA & NON-MELANOMA SKIN CANCER 2018 has been accredited by the Italian Ministry of Health for 13,3 ECM credits (Event number: 215872; Provider number: 322).
The specialities and disciplines (only for Italian participants) able to apply for Italian ECM credits are: Biologo; Infermiere; Medico Chirurgo, nelle Discipline di: Dermatologia e Venereologia; Ematologia;
The ECM certificate will be available for Italian participants after completing the evaluation test as well as 90% of attendance of the entire congress. Italian participants will be asked to record attendance each day.
RegistrationThe Meeting is free to attend. Please confirm the participation to the Organizing Secretariat:
Via J. Melani, 19/23 – 59016 Poggio a Caiano (PO) Tel. 055 8797796 – 8777875 Fax 055 8797843 [email protected]
Sede Legale ed Operativa: Via Aurora, 39 – 00187 RomaTel. 06 48906436 – 42012177 Fax 06 4821566 [email protected] - www.nicocongressi.it
Provider ECM n. 322
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
Technical facilitiesFacilities will be available for computer presentations and overhead projections. A business center with PC (Powerpoint for Windows) will be available for check and preview of presentations. It is essential that speakers take their presentation to the business center at least one hour before the session starts.The center will be open at the following times:
thThursday, April 12 , from 1.30 p.m. to 7.30 p.m.thFriday, April 13 , from 7.30 a.m. to 6.00 p.m.
thSaturday, April 14 from 7.30 a.m. to 5.00 p.m.
Lunches and coffee breaksLunches and coffee breaks will be served in the Meeting area.
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
Fondazione Internazionale Menarini Symposia n. 381
SKIN CANCER 2018 - Florence, April 12 - 14 , 2018th th
