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838 MEDICAL STUDENTS ABROAD answer even in the most unlikely conditions, where the price of the foodstuff was already comparatively cheap so that the total reduction in expenditure would only be small. It was also desired to make the experiment where purchasing power was very small. A mining village in the county of Durham was therefore selected as being one where the per- centage of those unemployed for continuous long periods was very high. There were 2437 unemployed (insured) male workers, with 3799 dependants, in a population of 5000 insured workers and 19,000 total inhabitants. The experiment was confined to the families of the unemployed and was carried out in February and March. Families containing up to three persons could purchase 1-1 stone of potatoes weekly, and larger families proportionately more. Instead of paying 10., the ruling price for this amount, the 11 stone could be bought for 6d., thus saving 4. a week. It was also particularly desired to test how .the trade of retailers of potatoes in the area would be affected and the cooperation of the shopkeepers was secured. The full number of vouchers for cheap potatoes was issued and only 7-3 per cent. of these were not used. The normal sales of potatoes in the retail shops fell by 40 per cent., but the total consumption in the whole area rose by 96 per cent. When this figure is corrected for any possible source of error, an increased con- sumption of 69 per cent. is still shown. The main thesis-that increased consumption will result from lowering the price of an already cheap staple food- stuff, when purchasing power is very small-appears therefore to be proved, as it was scarecely possible to doubt that it would be. But to implement this conclusion is another matter. MEDICAL STUDENTS ABROAD ACCORDING to a report by the Council on Medical Education and Hospital it appears that 710 Americans enrolled as medical students in schools outside the United States in the academic year 1930-31. If still studying abroad these students will probably finish their course during this year or next, and it may be expected that most of them plan to return to the United States to practise. It was a considera- tion of the problem created by this migration that led the Federation of State Medical Boards to harden their hearts against American students matriculating abroad and not to admit them to any licensing examination without producing satisfactory evidence of pre-medical education. The numbers in question are still by no means negligible, for during the last academic year 1934-35 there were known to be 1471 American students training in 97 institutions abroad, and 199 who graduated or completed their medical training during that time. The report contains a caustic remark that of 502 students whose names were supplied to the Association of American Medical Colleges this year 106 had made application to medical schools in the United States without success since 1931, and it is hinted that some of these students have signified their inability to obtain a medical education in the U.S.A. by rejection at 25 different medical schools. Various European countries have, it seems, sent representatives to the U.S.A. to discuss measures for dealing with the students who come over, and it may be interesting to note which European schools at the present time especially are offering hospitality to American students. For the academic year 1934-35 the highest numbers of students were enrolled, in descending 1 Jour. Amer. Med. Assoc., August 31st, 1935, p. 688. order, at Edinburgh Royal Colleges 190, University of Rome 161, University of Bern 114, University of Basle 83, University of Zurich 72, University of St. Andrews 69, University of Paris 63, Friedrich- Wilhelm University, Berlin, 62. A footnote to the table of figures suggests that the totals of 1471 enrolled and 199 who completed course should be larger, inasmuch as the following schools, viz., Vienna, Bologna, Naples, St. Mungo’s, Glasgow, and Geneva, which previously reported- large numbers of American students, do not now figure in the list. SKIN DISINFECTION USERS of Harrington’s solution may be interested to know that its virtues have been rediscovered in the United States. J. A. Vaichulis and Lloyd Arnold, who make no reference to Harrington’s solution, have presumably repeated the steps in argument or experiment which led to its formulation, for the skin disinfectant evolved by them contains almost identical amounts of mercuric chloride, hydrochloric acid, and alcohol; it differs in containing also 10 per cent. of acetone and 0-2 per cent. of chrysoidin Y, the former serving to dissolve fat and thus assist penetration, the latter giving characteristic colour and some added disinfectant power. The phenol coefficient of this solution, using Staphylococcus aureus as the test organism, was found to be 357. It is cheaper than tincture of iodine and much cheaper than solutions of other mercurial compounds such as mercurochrome or metaphen, and it is said to have been used successfully not only for preparing the skin in 185 cases of operation on the neck or abdomen, but in 300 cases of gunshot wounds and automobile accidents, another matter altogether, since the sterilisation of intact skin and the disinfec- tion of a wound are quite different problems. These claims involve two questions which are in a highly unsatisfactory position. One is the true disinfecting capacity of mercury salts under clinical conditions. Although Geppert exposed the fallacy in Koch’s original experiments with mercuric chloride no less than forty-five years ago, numberless papers have continued to appear up to the present day reporting experiments in which inhibitory as distinct from bactericidal action is ignored. The conditions of a test of mercuric chloride can be so arranged as to give almost any result, but the nearer those condi- tions approach to those obtaining in the body, which is tantamount to saying the richer the medium employed, the less does its disinfecting power appear to be. It is very desirable that a test suitable to the peculiar action of the heavy metals should come into general use. The second question does not arise directly from this paper, since no observations of the kind were made by Vaichulis and Arnold; it concerns the proper method of determining whether or no skin has been disinfected. Various authors have scraped or swabbed treated areas ; Tinker and Sutton 2 excised strips of skin from the edges of operation wounds, and others have cut portions of skin from animals, to furnish material for cultivation. Colebrook’s method 3 differs from all of these in securing adequate dilution of the inoculum and in furnishing quantitative results. This is admittedly a proceeding not lending itself to exact definition, but a nearer approach to uniformity of method would make it possible (which at present it is not) to compare the results obtained by different experimenters. 1 Surg., Gyn., and Obst., 1935, lxi., 333. 2 Jour. Amer. Med. Assoc., 1926, lxxxvii., 1347. 3 Jour. Obstet. and Gyn. of Brit. Empire, 1933, xl., 966.
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Page 1: SKIN DISINFECTION

838 MEDICAL STUDENTS ABROAD

answer even in the most unlikely conditions, wherethe price of the foodstuff was already comparativelycheap so that the total reduction in expenditurewould only be small. It was also desired to makethe experiment where purchasing power was verysmall. A mining village in the county of Durhamwas therefore selected as being one where the per-centage of those unemployed for continuous longperiods was very high. There were 2437 unemployed(insured) male workers, with 3799 dependants, in apopulation of 5000 insured workers and 19,000 totalinhabitants. The experiment was confined to thefamilies of the unemployed and was carried out inFebruary and March. Families containing up tothree persons could purchase 1-1 stone of potatoesweekly, and larger families proportionately more.

Instead of paying 10., the ruling price for thisamount, the 11 stone could be bought for 6d., thussaving 4. a week. It was also particularly desiredto test how .the trade of retailers of potatoes in thearea would be affected and the cooperation ofthe shopkeepers was secured. The full number ofvouchers for cheap potatoes was issued and only7-3 per cent. of these were not used. The normalsales of potatoes in the retail shops fell by 40 percent., but the total consumption in the whole arearose by 96 per cent. When this figure is correctedfor any possible source of error, an increased con-sumption of 69 per cent. is still shown. The mainthesis-that increased consumption will result fromlowering the price of an already cheap staple food-stuff, when purchasing power is very small-appearstherefore to be proved, as it was scarecely possible todoubt that it would be. But to implement thisconclusion is another matter.

MEDICAL STUDENTS ABROAD

ACCORDING to a report by the Council on MedicalEducation and Hospital it appears that 710 Americansenrolled as medical students in schools outside theUnited States in the academic year 1930-31. Ifstill studying abroad these students will probablyfinish their course during this year or next, and itmay be expected that most of them plan to returnto the United States to practise. It was a considera-tion of the problem created by this migration thatled the Federation of State Medical Boards to hardentheir hearts against American students matriculatingabroad and not to admit them to any licensingexamination without producing satisfactory evidenceof pre-medical education. The numbers in questionare still by no means negligible, for during the lastacademic year 1934-35 there were known to be1471 American students training in 97 institutionsabroad, and 199 who graduated or completed theirmedical training during that time. The reportcontains a caustic remark that of 502 students whosenames were supplied to the Association of AmericanMedical Colleges this year 106 had made applicationto medical schools in the United States withoutsuccess since 1931, and it is hinted that some ofthese students have signified their inability to obtaina medical education in the U.S.A. by rejection at25 different medical schools. Various Europeancountries have, it seems, sent representatives to theU.S.A. to discuss measures for dealing with thestudents who come over, and it may be interestingto note which European schools at the present timeespecially are offering hospitality to Americanstudents. For the academic year 1934-35 the highestnumbers of students were enrolled, in descending

1 Jour. Amer. Med. Assoc., August 31st, 1935, p. 688.

order, at Edinburgh Royal Colleges 190, Universityof Rome 161, University of Bern 114, University ofBasle 83, University of Zurich 72, University ofSt. Andrews 69, University of Paris 63, Friedrich-Wilhelm University, Berlin, 62. A footnote to thetable of figures suggests that the totals of 1471enrolled and 199 who completed course should belarger, inasmuch as the following schools, viz.,Vienna, Bologna, Naples, St. Mungo’s, Glasgow, andGeneva, which previously reported- large numbersof American students, do not now figure in the list.

SKIN DISINFECTION

USERS of Harrington’s solution may be interestedto know that its virtues have been rediscovered inthe United States. J. A. Vaichulis and Lloyd Arnold,who make no reference to Harrington’s solution,have presumably repeated the steps in argumentor experiment which led to its formulation, for theskin disinfectant evolved by them contains almostidentical amounts of mercuric chloride, hydrochloricacid, and alcohol; it differs in containing also 10 percent. of acetone and 0-2 per cent. of chrysoidin Y,the former serving to dissolve fat and thus assistpenetration, the latter giving characteristic colourand some added disinfectant power. The phenolcoefficient of this solution, using Staphylococcusaureus as the test organism, was found to be 357.It is cheaper than tincture of iodine and much cheaperthan solutions of other mercurial compounds suchas mercurochrome or metaphen, and it is said tohave been used successfully not only for preparingthe skin in 185 cases of operation on the neck orabdomen, but in 300 cases of gunshot wounds andautomobile accidents, another matter altogether,since the sterilisation of intact skin and the disinfec-tion of a wound are quite different problems. Theseclaims involve two questions which are in a highlyunsatisfactory position. One is the true disinfectingcapacity of mercury salts under clinical conditions.Although Geppert exposed the fallacy in Koch’s

original experiments with mercuric chloride no lessthan forty-five years ago, numberless papers havecontinued to appear up to the present day reportingexperiments in which inhibitory as distinct frombactericidal action is ignored. The conditions of atest of mercuric chloride can be so arranged as togive almost any result, but the nearer those condi-tions approach to those obtaining in the body, whichis tantamount to saying the richer the medium

employed, the less does its disinfecting power appearto be. It is very desirable that a test suitable tothe peculiar action of the heavy metals should comeinto general use. The second question does notarise directly from this paper, since no observationsof the kind were made by Vaichulis and Arnold; itconcerns the proper method of determining whetheror no skin has been disinfected. Various authorshave scraped or swabbed treated areas ; Tinker andSutton 2 excised strips of skin from the edges ofoperation wounds, and others have cut portions ofskin from animals, to furnish material for cultivation.Colebrook’s method 3 differs from all of these in

securing adequate dilution of the inoculum and infurnishing quantitative results. This is admittedlya proceeding not lending itself to exact definition,but a nearer approach to uniformity of methodwould make it possible (which at present it is

not) to compare the results obtained by different

experimenters.1 Surg., Gyn., and Obst., 1935, lxi., 333.

2 Jour. Amer. Med. Assoc., 1926, lxxxvii., 1347.3 Jour. Obstet. and Gyn. of Brit. Empire, 1933, xl., 966.

Page 2: SKIN DISINFECTION

839EARLY DIAGNOSIS OF AORTIC SYPHILIS

HAROLD WARD DUDLEY, F.R.S.

THE death on Oct. 3rd of Mr. H. W. Dudley, Ph.D.,F.R.S., at the early age of 47, removes one of theoutstanding research workers in biochemistry as

applied to medical problems. As a student at Leedshe came under the influence of J. B. Cohen, one ofthe first organic chemists in this country to see thepromising future that lay before biochemistry. Aresearch scholarship enabled him to spend two

years in Berlin working at the structure of purinesunder Wilhelm Traube in Emil Fischer’s laboratory ;from there he went to Herter’s laboratory in NewYork where he met H. D. Dakin, another of Cohen’sold students, and entered into a fruitful collaborationwith him. Most noteworthy perhaps was the dis-

covery of the enzyme glyoxalase, which rapidlyconverts methyl glyoxal at body temperature tolactic acid. During the late war he was attachedto the R.A.M. College in London, and was sent tothe United States in charge of an anti-gas mission.On his return to England he joined the staff of theMedical Research Council as chief biochemist, a postthat brought him into close contact with colleaguesworking in many different fields of medical research,to whom he gave freely of his deep knowledge ofchemistry and his skill in complex analysis.The first problem presented to him was that of

the chemical nature of the constituents of the pos-terior lobe of the pituitary body ; he was able toshow that the pressor constituent and the con-

stituent responsible for causing contraction of uterinemuscle were separable by chemical means. He thenturned his attention to the newly discovered insulin,and was the first to devise a method of preparation(still used in its manufacture) which gave a dry stableproduct having ten times the activity of the originalcrude material, and to suggest that the hormoneitself was a complex protein derivative-a conclusionamply confirmed later by other workers. Meanwhilein collaboration with 0. Rosenheim and W. W.

Starling he proved the constitution of spermine andspermidine, two bases now known to be generaltissue constituents for which no physiological functioncan yet be even suggested. The importance of cer-tain vasodilator constituents of the animal bodywith a histamine-like action for the normal function-

ing of the capillaries had long been emphasised bySir Henry Dale. Dudley, in collaboration withW. V. Thorpe,- was able to identify the substancehaving this action with histamine itself, which wasisolated from several organs under conditions whichprecluded putrefactive changes. Next came a bril-liant research with Dale which led to the isolationof acetylcholine from horse and ox spleen. HereDudley’s analytical skill was shown at its best; hismethod of separating this unstable substance fromcholine and other substances present by means oftheir chloroplatinates bears the stamp of genius.Dudley’s last research, which was fortunately

brought to a successful conclusion before his untimelydeath, dealt with the active principle of ergot. Ithad been assumed that the substances active towardsthe uterine muscle were the alkaloids ergotoxine andergotamine, but in 1932 Chassar Moir obtained directevidence that aqueous extracts of ergot free fromthese complex alkaloids were active when adminis-tered by the mouth. The active principle musttherefore be different from any of those knownhitherto and Dudley undertook a chemical investiga-tion of this unknown substance in association withthe direct clinical observations of Moir. The resultwas the isolation of a new water-soluble alkaloid,

ergometrine, which in minute doses has the charac-teristic activity of ergot. This discovery of ergo-metrine, which solves a long-standing problem ofthe pharmacology of ergot and its use in therapeutics,has aroused widespread interest, as is shown bythe fact that it has already been confirmed, ineffect, in three other laboratories where researchwas independently in progress. While his maininterests were definitely in the laboratory Dudleydid not neglect those other biochemical activitieswhich he was called upon to perform. From 1922-24he was secretary of the Biochemical Society, andfrom 1925-30 joint editor with Prof. Harden of theBiochemical Journal. He was also for many yearsan assistant editor of Chemical Abstractsandwasrespon-sible for the high level of the section of abstracts

dealing with biochemistry. His great attainmentswere recognised in his election to the fellowship ofthe Royal Society in 1930.

EARLY DIAGNOSIS OF AORTIC SYPHILIS

SYPHILIS of the aorta usually causes death withina few years of its clinical recognition. Affectingmost often the ascending portion of the vessel it isliable to damage the mouths of the coronary arteriesand the cusps of the aortic valves. If the inflam-matory process is confined to the transverse or

descending part of the arch, these vital structuresescape and the prognosis is much less grave.

There is reason to think that the aortic wall isinvaded early in the course of syphilitic infection,and that it is not until the destructive process hasbeen at work for many years that symptoms ariseand the diagnosis of aortic syphilis is made. Hencethe relatively poor results of treatment. In manydiseases subjective symptoms, indicating alteredfunction, precede any detectable alteration in struc-ture. In aortic syphilis, however, it has been sug-gested that a structural change may be recognisedlong before symptoms arise. E. P. Maynard andco-workers claim to diagnose such cases radio-graphically, and they have been able to investigate346 patients by working in cooperation with a syphilisclinic, and investigating the cardiovascular systemof every patient attending it, irrespective of the

stage of the disease and the symptoms complained of.All who have studied the X ray appearances of theaorta will appreciate, nevertheless, that the recog-nition of slight abnormality in the width of thisvessel is not easy. The width varies with age andwith the shape of the chest, and can be altered byother factors such as atheroma and high blood

pressure. The investigators use the method of

Vaquez and Bordet for measuring the vessel width,and after excluding cases with high diaphragm,scoliosis, a systolic pressure over 140 mm. Hg, orrheumatic aortic lesions, and patients with arterio-sclerosis or over fifty years of age, they accept anymeasurement over 7 cm. as pathological, and onebetween 6 and 7 cm. also, if the ascending aorta isprominent. Of 77 patients examined within nine

years of infection, 14 had aortic syphilis, but only4 of these had symptoms referable to the lesion.The proportion with aortitis gradually increasedwith the period since infection, and so did the pro-portion of these with symptoms ; out of 17 patientsexamined thirty years or more after infection 15were found to have cardiovascular syphilis. In the145 patients who showed evidence of aortic syphilisthe mean interval between infection and evidence of

1 Arch. Internal Med., 1935, lv., 873.


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