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Smarter Planet: Life Sciences

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At the center of smarter life sciencesis an increasingly more networked operation focused on the end patient. The result is also a safe, effective and valued treatment solution targeted at the patient.
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© 2010 IBM Corporation Let’s Build A Smarter Planet: What will it mean for Life Sciences? George Mattathil - 5/17/2011
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Page 1: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Let’s Build A Smarter Planet: What will it mean for Life Sciences?

George Mattathil -

5/17/2011

Page 2: Smarter Planet: Life Sciences

© 2010 IBM Corporation

The reality of living in a globally integrated world is upon us.

Safety, quality, efficacy of products is challenged more than ever before

Outdated and inefficient (drug) research and development (R&D) has contributed

to expiring patents, dry pipelines and cost

Generic alternatives abound as pricing pressures increase

Globalization efforts and the new economic environment have

constrained resources

The world is connected: economically, socially and technically.

Page 3: Smarter Planet: Life Sciences

© 2010 IBM Corporation

The need for progress is clear.

Dollars invested in US pharma

and biotech R&D in 2008. Only 4

truly innovative products were

delivered in the same period.2

65.2 billion 50% of patients drop out of their

treatment within the first

year.20% of prescriptions go

unfilled in hard economic times

and 30% of prescriptions are

not refilled.1

90% of drugs work in only

30-50% of people3

74 billion Dollars US lost due to

a 10% counterfeit

drug supply4

1 ―ECONOMIC CRISIS : Pharma Sales Will Drop As Patients Cut Back on Prescriptions‖

2 R&D Spending by U.S. Biopharmaceutical Companies Reaches Record Levels in 2008 Despite Economic Challenges, March 10, 2009

3 ―Demolished - the myth that allows drugs giants to sell more‖. , The Independent, Dec. 8, 2003.

4 ―Partnership for Safe Medicines Arms Public Against Counterfeit Drugs‖ Dec. 2, 2008 and IBM analysis

Page 4: Smarter Planet: Life Sciences

© 2010 IBM Corporation

More innovative discovery & development

Better compliance with treatment

Improved patient insights Reduced risk from counterfeits

The opportunity for progress is clear.

Smarter Life Sciences:

Metabasis therapeutics, Inc.

A biopharmaceutical company in the U.S.

speeds time to market for metabolic- and liver-

disease therapies

Smarter Life Sciences:

Merit Foundation

A Netherlands based non-commercial, international

medical organization accesses thousands of

anonymous patient records and monitors patients’

progress and benchmark responses to treatment

against information about others

Smarter Life Sciences:

Ecole Polytechnique Federale de Lausanne

A major Swiss research institute harnesses the

power of supercomputers to model the human brain,

speeding the search for causes and cures of

neurological and psychiatric diseases with the ability

to run simulations in close to real time

Smarter Life Sciences:

GSMS, Inc.

A small U.S. wholesale pharmaceuticals distributor,

contract manufacturer and packaging company

deploys a pharmaceutical track and trace solution

ahead of the competition The demand for change is strong

The 2008 Global CEO Study: ―The Enterprise of the Future‖

Page 5: Smarter Planet: Life Sciences

© 2010 IBM Corporation

The demand for change is strong.

Gap between envisioned

change and past success

at managing it.

8 in 10 Life Sciences leaders

anticipate substantial

change ahead.

22%

Change Needed

LIFE SCIENCES CEO’S GLOBAL CEO’S

Page 6: Smarter Planet: Life Sciences

© 2010 IBM Corporation

For life sciences companies, this means leading in the face of global challenges brought on by three key drivers while overcoming two key inhibitors.

COST AND REVENUE PRESSURES

GROWING RAPIDLY

Restructured business models to

streamline overall operations including

strategic outsourcing, partnering and

turning to emerging markets

REGULATORY, POLITICAL AND SOCIETAL

PRESSURES INTENSIFYING

Legislation is forcing investments in

supply chain traceability and promotional

spending analysis

BETTER UNDERSTANDING OF THE

FUNDAMENTALS OF THE DISEASE

Predictability of a treatment’s efficacy and

safety will drive improved outcomes

PRODUCT MODELS MOVE TO BIOLOGICS

Drugs targeted at a defined population

as well as disease-modifying and preventative

in nature

DISRUPTIVE SCIENCE AND

TECHNOLOGY EMERGING

Increased use of medical imaging and

biomarkers in the move to targeted treatments

and personalized medicine

DRIVERS INHIBITORS

Page 7: Smarter Planet: Life Sciences

© 2010 IBM Corporation

People and the

organization

Technology

Processes

A smarter system forges partnerships in order to deliver treatment solutions which are targeted at the individual patient.

Enhanced

communication with

end consumer

Compliance

Patient persistence

Consumer insights

Collaboration with

Other life sciences

companies

Biotech

Medical device

and diagnostic

manufacturers

Contract

organizations

Academic centers

Hospitals / clinics

Patients

Smarter life sciences

organization

Network of smart partners

Patient / consumer insights

Smarter Discovery

& Development

Smarter

Supply

Chain

Smarter

Sales &

Marketing

Page 8: Smarter Planet: Life Sciences

© 2010 IBM Corporation

It’s a new world—and life sciences organizations are key players in an economy that demands increased value, safer solutions, better outcomes, sustainability and accountability.

ENGAGE

Enable life sciences to take an active

role in empower a healthier society and

patients by collaborating to improve

breakthrough therapies.

INNOVATE

Develop new business models to

compete more effectively. Fuel

innovation in R&D and drive

greater discovery productivity.

OPERATE EFFECTIVELY

Align and optimize processes to

support patient centered healthcare

delivery and patient safety to drive

better outcomes and an enhanced

experience. LIFE

SCIENCES

Page 9: Smarter Planet: Life Sciences

© 2010 IBM Corporation

An opportunity for life science organizations

to think and act in new ways.

Innovate Operate Effectively Engage

+ + =

Page 10: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Smart life sciences: Innovate.

SMART IS

Improving the efficiency of drug discovery

and development through to reformulation

of existing drug products to extend

product life cycle.

SMART IS

Fueling clinical innovation with much

more processing power while

decreasing operating costs.

SMART IS

Integrating all relevant data, reproducing

the control principles of a biological

system and simulating how it

will respond.

SMART IS

Reducing attrition rates and costs

during discovery by use of high

performance computing.

Page 11: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Smart life sciences: Operate Effectively.

SMART IS

Automating baseline activities in the

supply chain increases responsiveness to

free up time for employees to manage

critical exceptions and focus on higher

value activities.

SMART IS

Automatically analyzing and correlating

information from multiple sources to

identify areas of risk and regulatory

compliance exposures.

SMART IS

Enabling research beyond the current

―trial, file, and archive‖ data usage model

through clinical & safety data accessible

across studies.

SMART IS

Combating risk by building

intelligence into both products

and packaging.

Page 12: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Smart life sciences: Engage.

SMART IS

Identifying actions to stem the impact

of chronic diseases like diabetes, heart

disease or stroke by modeling

disease progression.

SMART IS

Driving more innovation and short term

revenues through collaboration.

SMART IS

Monitoring impending disasters and

proactively responding so supply of

targeted treatment is available immediately.

SMART IS

Building in interconnectivity across a

network to provide a hands-on view of

the entire supply chain for all parties.

Page 13: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Smart life sciences:

Ecole Polytechnique Federale de Lausanne (EPFL):

Embarked on Project Blue Brain, a joint research venture

with IBM to create a model of the fundamental building

blocks of the human brain, unprecedented in its scope –

ultimately generating functional models for 10,000

morphologically complex neurons.

Merit Foundation: developed METEOR – Measurement of

Efficacy of Treatment in the Era of Outcome in

Rheumatology – an Internet-based solution that will

revolutionize and improve patient treatment. Clinicians now

have access to thousands of anonymous patient records,

covering several countries and many hospitals; they can

learn from one another on the best treatment for patients.

Innovate.

Innovate.Engage.

Engage.

National Genographic: created a DNA analysis repository that lets researchers and scientists analyze gathered genetic

data and identify patterns among the samples. Private citizens can also contribute samples to the DNA repository, hosted in

an IBM DB2® data server, and view personalized ancestral migration profiles on the organization’s Web site. This has

Establishes one of the largest centralized collections of genetic information, increasing collaboration among scientists

and researchers.

Page 14: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Golden State Medical Supply, Inc. (GSMS):

Implemented the Pharma Track & Trace Solution using

two-dimensional barcodes, radio frequency

identification (RFID) and other sensors to track

product movements. Puts GSMS in an advantageous

competitive position by making it one of the first

distributors to comply with the new regulations.

Operate Effectively.

Metabasis Therapeutics: Highly-accurate, first-of-a-

kind simulation software significantly lowers drug

discovery time and costs by eliminating 80% of the

compounds to be synthesized and tested in the lab.1

Fujita Pharmaceutical LTD, Co. : Improved its total

project management capabilities. The new solution

helps the company minimize out-of-stock instances

by consistently managing sales, production,

purchases of raw materials and accounting through a

single system.

Bilcare Limited: Developed a Track-and-Trace

Solution framework to seamlessly integrated into any

supply chain system, providing real-time product

authentication. The technology helps detect

counterfeit goods, potentially saving millions of lives

Page 15: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Smart life sciences: IBM Research Projects

Automatically analyzing and correlating

information from multiple sources to identify

areas of risk and regulatory compliance exposures.

Dynamic Infrastructure Research Examples

Leveraging Blue Gene for large scale simulation

in the drug discovery process.

Smart Work Research Example

Building governance and maintenance tools to

support benefit configuration, research, and

correction processes.

Protecting the privacy of biometric data by

creating an anonymous biometrics recognition

system that scales to large populations.

New Intelligence Research Example

Page 16: Smarter Planet: Life Sciences

© 2010 IBM Corporation

At the center of smarter life sciencesis an increasingly more networked operation focused on the end patient.

COLLABORATING with other biophamra, academia

SHARING patient insights

UNDERSTANDING

fundamental of the

disease

INTEGRATING

all relevant data both

internally and externally

CONVERGING across industries

MONITORING and responding

to signals

MEASURING your progress

and plan

IMPROVING operations internally

COMPLYING with regulations

The result is also a safe, effective and valued treatment

solution targeted at the patient.

IMPROVED PATIENT INSIGHTS

REDUCED RISK FROM COUNTERFEITS

BETTER COMPLIANCE WITH TREATMENT

MORE INNOVATIVE DISCOVERY & DEVELOPMENT

Page 17: Smarter Planet: Life Sciences

© 2010 IBM Corporation

The imperative for life sciences today is clear.

ENGAGE

Interconnect researchers

from academic, industry and

regulators to bolster product

pipelines

Bridge internal silos with

better collaboration tools and

infrastructures

Build an integrated network

of manufacturing, and

distribution partners

OPERATE EFFECTIVELY

Optimize core systems and

infrastructure to reduce costs

and to more flexibly service

new business demands

Use technology to

communicate, share information

and assist in decision-support

Employ a fact-based,

quantitative risk management

approach in the supply chain

and by building intelligence into

products and packaging

INNOVATE

Develop strategies in

support of advanced

therapies and technologies,

such as gene and cell

therapies and

nanotechnology

Fuel drug discovery by

investing in innovative

decision-making

approaches

Maximize development with

the integration of modeling

and simulation into new

clinical trial programs

Use social networking to

connect globally to gather

insights to fuel innovation

Page 18: Smarter Planet: Life Sciences

© 2010 IBM Corporation

IBM’s solution strategy is aligned with the needs of all stakeholders of the life sciences companies.

LIFE SCIENCES SYSTEMS ARE FOCUSED ON… IBM IS INVESTING IN…

Streamline and transform

Collaborate and empower

Innovate and thrive Systems biology

Nanotechnology

Smarter Analytics & Information Agenda

Clinical decision support systems

Customer segmentation / e-detailing

Business process modeling, analytics and performance

management

Life Sciences Hub

Biopartnering strategy

Interoperability

Medical home: Patient-centered collaborative care

Patient portals

Collaborative platforms & tools

Risk Modeling

Universal Data Model/Warehouse

The New Pharma Commercial Model

Marketing and Sales

Regulatory Compliance

Pharmacoviligence

Content Management

Pharma Track and Trace

Page 19: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Let’s work together to drive

real progress in our world.

We’ve only just begun to uncover what is possible on a smarter planet.

The world will continue to become smaller, flatter

and smarter. We are moving into the age of the

globally integrated and intelligent economy, society

and planet.

To thrive in a smarter planet, life sciences

organizations need to transform so they are more

streamlined internally and collaborating effectively

externally to deliver more innovative products.

There’s no better time to start building a smarter life

sciences industry to provide more patient-centric

treatment for society.

Page 20: Smarter Planet: Life Sciences

© 2010 IBM Corporation

Trademarks and notes

IBM Corporation 2009

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Other company, product and service names may be trademarks or service marks of others.

References in this publication to IBM products or services do not imply that IBM intends to

make them available in all countries in which IBM operates.


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