ISBN: 978-1-5108-0106-6
Society for Biomaterials Annual Meeting and Exposition 2015 Driving Biomaterial Innovation and the Race to Translation
Charlotte, North Carolina, USA 15-18 April 2015
Transactions of the 39th Annual Meeting Volume XXXVII
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TABLE OF CONTENTS
ADVANCED HYDROGELS WITH HIERARCHAL STRUCTURES FOR BIOLOGICAL APPLICATIONS A Strategy for Reversible Control of Hydrogel Modulus to Probe Myofibroblast Activation .................................................................. 1
A. M. Rosales, K. M. Mabry, C. B. Rodell, J. A. Burdick, K. S. Anseth
Dual-Layer PEG Hydrogels Promote Islet Engraftment and Function in an Alternative Transplant Site ............................................. 2J. D. Weaver, D. M. Headen, A. J. Garcia
Microporous Annealed Particle Hydrogels for Hierarchical Tissue Mimetics ........................................................................................... 3W. M. Weaver, D. R. Griffin, D. Di Carlo, T. Segura
Hierarchically Structured Protein Hydrogels for Controlled Nanoparticle Release .................................................................................. 4J. Simon, A. Ghoorchian, A. Chilkoti, G. Lopez
Ultrastiff Nanocomposite Hydrogels for Biomedical Applications ............................................................................................................... 5M. Jaiswal, J. Xavier, P. Desai, J. Carrow, A. K. Gaharwar
Photopatterned Immobilization of Site-Specifically Modified Proteins within 3D Gels ............................................................................ 6J. A. Shadish, C. K. Arakawa, C. A. Deforest
BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) Fabrication of Biomimetic µfluidic Networks Using Image-Guided Photocavitation-Mediated Hydrogel Degradation ......................................................................................................................................................................................................... 7
K. A. Heintz, J. L. West, J. H. Slater
Patterned Tissue Precursors Microcontact Printed from Shape-Changing Hydrogel Stamps ................................................................. 8O. O. Akintewe, R. G. Toomey, N. D. Gallant
Impact of Collagen-Incorporation within Electrospun Vascular Conduits on Lipid Oxidation and Conduit Mechanics ............................................................................................................................................................................................................ 9
K. Birthare, M. Shojaee, C. G. Jones, J. Brenner, C. A. Bashur
In Situ Deposition of Polymer Sealants via Solution Blow Spinning .......................................................................................................... 10A. M. Behrens, B. J. Casey, M. J. Sikorski, A. D. Sandler, P. Kofinas
Design of a Sugar-responsive Hydrogel for a Sacrificial Template to Create Vascularized Tissue Constructs. ................................... 11M. Yamamoto, K. Arimoto, Y. Tabata
Airbrushing Polymer Fibers for Tissue Engineering Applications: Impact of a Device Design on Fiber Quality ............................... 12X. Palmer, W. Tutak
BIOLOGICALLY DERIVED MATERIALS FROM NATURAL SOURCES Eumelanin As Biologically Derived Cathodes for Aqueous Sodium Ion Energy Storage ........................................................................ 13
Y. J. Kim, J. F. Whitacre, C. J. Bettinger
Porcine Acellular Muscle Matrix Scaffolds Enhance Restoration of Contractility in a Murine Model of Muscle Injury ................................................................................................................................................................................................................. 14
M. M. Stern, A. R. Stern, E. E. Goff, C. R. Bergman, O. L. Latham, B. T. Corona
Degradable GAG-based Microparticles with Tunable Sulfation for Growth Factor Delivery within MSC Aggregates ......................................................................................................................................................................................................... 15
L. E. Tellier, T. Miller, T. E. Rinker, T. C. McDevitt, J. S. Temenoff
Mechanically Dynamic Hyaluronic Acid Hydrogels for Investigating Cellular Mechanotransduction................................................. 16S. R. Caliari, M. Perepelyuk, R. G. Wells, J. A. Burdick
Combination Approach for Limiting Epithelial Downgrowth Around the Percutaneous Implants: Use of Biomimetic Coatings in Conjunction with Negative Pressure Wound Therapy ....................................................................................... 17
K. N. Bachus, S. Jeyapalina, S. Cook, F. R. Nichols
Delivery of BMP-2 from Keratin Hydrogels with Tunable Rates of Degradation.................................................................................... 18S. Haque, M. Li, K. Lasance, J. M. Saul
BIOMATERIALS FOR REGENERATIVE ENGINEERING Nanofibrous Bicomponent Scaffolds for the Dual Delivery of NGF and GDNF: Controlled Release of Growth Factors and their Biological Effects................................................................................................................................................................ 19
C. Liu, M. Wang
RGD Functionalized Polyethylene Glycol Hydrogels Support Proliferation and In Vitro Chondrogenesis of Human Periosteum Derived Cells................................................................................................................................................................................. 20
A. K. Kudva, J. Patterson
Functional Muscle Regeneration by Delivery of Mesenchymal Stem Cells and Basic Fibroblast Growth Factor ............................... 21Y. Xu, M. Fu, Z. Li, X. Li, Z. Fan, P. Anderson, Z. Liu, J. Guan
Combination Therapy of Stem Cell Derived Neural Progenitors and Drug Delivery of Anti-Inhibitory Molecules for Spinal Cord Injury ..................................................................................................................................................................................... 22
T. Wilems, S. Sakiyama-Elbert
Antimicrobial Oxygen-Generating Injectable Scaffold for Wound Healing ............................................................................................. 23W. Lv, Y. Sun, Y. Deng
Evaluation of a Pre-Vascularized Osteoinductive Polymeric Scaffold for Bone Tissue Regeneration................................................... 24B. L. Taylor, J. Freeman
Thiol-Maleimide Reaction Speed Effects on Hydrogel Homogeneity......................................................................................................... 25N. Darling, T. Segura
3D Printed Bioactive Nanocomposite Scaffolds for Osteochondral Regeneration.................................................................................... 26N. J. Castro, L. G. Zhang
CARDIOVASCULAR BIOMATERIALS Characterization of Host Cellular Response to Bioprostheses in Rat Subdermal Implant Calcification Model .................................. 27
H. Tam, N. Parchment, N. Vyavahare
Transcatheter Fiber Heart Valve: Effect of Crimping on Material Performances .................................................................................. 28F. Khoffi, F. Heim
Surface Chemistry Induction of Activation and Osteoblastic Differentiation of Valvular Interstitial Cells ......................................... 29M. N. Rush, E. L. Hedberg-Dirk
Bioactive Microparticle Assembly in Microchanneled Hydrogel for Guided Vascular Network Formation........................................ 30M. K. Lee, M. H. Rich, A. Shkumatov, J. Lee, H. Kong
Fetuin-A Therapy: A New Approach for the Treatment of Vascular Calcification ................................................................................. 31J. L. Cunningham, E. S. Vasquez, K. B. Walters, C. L. Simpson
Application of Corrosion-Resistive Polyetherimide Coating to Vascular Magnesium Stent................................................................... 32M. Kang, S. Kim, J. Song, H. Kim
Conductive Polypyrrole-polycaprolactone Scaffolds for Electrophysiological Maturation of Cardiomyocytes ................................... 33B. Spearman, J. Porter, E. A. Lipke, A. J. Hodge
A Shape Memory External Support to Improve Vein Graft Patency ........................................................................................................ 34T. Boire, C. Brophy, H. Sung
RECENT ADVANCES IN SURFACE MODICATION OF BIOMATERIALS Aminated Elastin-Like Polypeptide Copolymer Coatings for Liver Cell Culture .................................................................................... 35
A. V. Janorkar, C. A. Weeks, E. Vasquez, K. Walters
Molecularly Imprinted Polymers on Surface-Modified Gold Nanoparticles for Biosensing Applications ............................................ 36C. N. Koepke, H. R. Culver, N. A. Peppas
Improving Silicone Elastomer Hydrophilicity .............................................................................................................................................. 37R. L. Koch, D. A. Prawel, S. P. James
Multi-scale Surface Modification of Ti for Orthopedic Implant Application ........................................................................................... 38T. Jang, S. Kim, B. Moon, J. Song, H. Kim
Surface Polymerization of Oligonucleotide Aptamers for the Enhanced Capture and Release of Target Cells ................................... 39E. Richards, S. Li, N. Chen, M. Battig, Y. Wang
Improved MC3T3 Cellular Growth on Nano-grained 316L Stainless Steel Obtained by Linear-plane Machining Severe Plastic Deformation.............................................................................................................................................................................. 40
M. Shayan, M. Moradi, R. Shankar, Y. Chun
Shape Memory Polymer Recovery Activates Nano-scale Polyelectrolyte Multi-layer Topographical Wrinkles .................................. 41A. Ash-Shakoor, E. B. Finkelstein, J. H. Henderson, P. T. Mather
Capture of Circulating Tumor Cells Using Heteromultivalently Decorated Microfluidic Surfaces ...................................................... 42P. Siva, C. Modery-Pawlowski, U. Sekhon, A. Gupta
VACCINE DELIVERY VEHICLES Self-assembling Peptide-based Vaccines for Cocaine Addiction ................................................................................................................. 43
J. Rudra, R. Appavu, Y. Ding, C. Ding, S. Stutz, K. Cunningham, J. Zhou
Polyanhydride Nanovaccines Against Viral Infections in Shrimp .............................................................................................................. 44Y. Phanse, S. Puttamreddy, D. Loy, K. Ross, J. Vela Ramirez, B. Narasimhan, L. Bartholomay
Dendritic Cell Subsets Interact with CpG-carrying Pathogen Mimicking Particles in a Phenotype Specific Manner ........................ 45J. Leleux, P. Pradhan, K. Roy
Carbohydrate Modification of Polyanhydride Nanoparticles and Polymer Chemistry Influence Interactions with Dendritic Cells................................................................................................................................................................................................... 46
J. Goodman, J. Vela Ramirez, P. Boggiatto, R. Roychoudhury, N. Pohl, M. Wannemuehler, B. Narasimhan
Design of “Carrier-Free” Polyelectrolyte Multilayer Vaccines Assembled from Immune Signals......................................................... 47Y. Chiu, P. Zhang, J. M. Gammon, C. M. Jewell
PROMPT: Polyanhydride-Releasing Oral Microparticle Technology as an Oral Vaccine Strategy ..................................................... 48L. A. Sharpe, O. Haddadin, J. Thirumavalavan, Y. Khairandish, N. A. Peppas
Immunogenicity of a Polyinosinic-Polycytidylic Acid (Poly(I:C))-Adjuvanted Microparticle Vaccine for Leishmaniasis .................................................................................................................................................................................................... 49
Q. Wang, M. Barry, C. Seid, E. Hudspeth, C. McAtee, M. Heffernan
Polyanhydride Nanovaccine Elicits Germinal Center Formation and Isotype Switching ....................................................................... 50J. E. Vela Ramirez, L. T. Tygrett, J. Hao, H. H. Habte, M. W. Cho, N. S. Greenspan, T. J. Waldschmidt, B. Narasimhan
PANEL DISCUSSION: INDUSTRIAL INNOVATIONS IN BIOMATERIALS Industrial Innovations in Biomaterials .......................................................................................................................................................... 51
A. Salamone, B. Ratner, D. L. Kaplan, C. E. Schmidt, R. S. Ward, L. Pinchuk
BENCHTOP MODELS TO SUPPORT MEDICAL DEVICE AND PHARMACEUTICAL INVENTION AND COMMERCIALIZATION Degradation of PLLA Tubes in a Pulsatile Flow Loop as a Model for Cardiovascular Stent Degradation .......................................... 52
M. L. Dreher, S. Nagaraja, Q. Lu, R. Malinauskas, B. Batchelor
Effects of Fatigue Loading on Absorbable Stent Sub-Unit Degradation ................................................................................................... 53M. L. Dreher, S. Nagaraja, B. Batchelor
Ventilator-Endotracheal Tube-Lung Benchtop Model for Luminal Occlusion ........................................................................................ 54C. M. Magin, R. M. May, M. R. Mettetal, A. Potthoff, M. D. Twite, S. T. Reddy
Development of a High-Throughput Ultrasound Technique for the Analysis of Tissue Engineering Constructs ................................ 55M. Goss, J. Stukel, R. Willits, A. Exner
Bench-Top Assay of Inflammation with Human Macrophages on Biomaterials...................................................................................... 56C. E. Witherel, K. L. Spiller
Platelet and Leukocyte Counts as Hemocompatibility Indicators for Biomaterials: An Evaluation of ASTM Standard Test Method F2888-13 .................................................................................................................................................................... 57
Q. Lu, J. M. Nehrer, R. Malinauskas
CHARACTERIZATION OF MICROENVIRONMENT OF IMMUNE CELLS IN WOUND HEALING Affinity-based Controlled Release Scaffolds for Modulation of Macrophage Phenotype in Chronic Diabetic Ulcers......................... 58
S. Nassiri, K. L. Spiller
Microstructural and Functional Analysis of Polymeric Composite Materials for Near Infrared Imaging ........................................... 59A. Stevenson Jr., L. Reese, T. Hill, J. McGuire, A. Mohs, R. Shekhar, L. Bickford, A. Whittington
Chemical Imaging of the Breast Tumor Microenvironment ....................................................................................................................... 60L. Gamble, B. Bluestein, D. Graham, F. Morrish, D. Hockenbery, P. Porter
Effects of Adhesive Cues on Macrophage Cytokine Secretions: A Single Cell Analysis .......................................................................... 61F. Y. McWhorter, T. D. Smith, T. Chung, W. F. Liu
Mechanically- & Biologically-Tunable Polyethylene Glycol Hydrogels for Quantitative Neutrophil Migration Assays................................................................................................................................................................................................................. 62
B. J. Walker, A. L. Gonzalez, H. M. Lauridsen
Study the Effect of Electrical Stimulation Through the Conductive Membranes on the Wound Healing Gene Expression in Normal Human Dermal Fibroblasts ...................................................................................................................................... 63
H. Park, M. R. Rouabhia, D. L. Lavertu, Z. Zhang
Investigating the Migratory Behavior of Macrophage Subtypes ................................................................................................................ 64T. Smith, W. F. Liu, J. Hsieh
The Response of Progenitor Cells and Macrophages on a Bone Substitute to Biologically Relevant pH Levels .................................. 65C. O. Horton, W. Bridges Jr., K. Burg
DRUG DELIVERY FOR IMMUNOMODULATION Molecular Dissemination into Local and Systemic Tissues is Regulated by Molecular Size and Tumor Vascular Status: Implications for Targeted Drug Delivery in Cancer Immunotherapy .......................................................................................... 66
N. Rohner, S. N. Thomas
Dextran Coated Cerium Oxide Nanoparticles Act as Antioxidants ........................................................................................................... 67E. Alpaslan, M. Vargas, A. K. Roy, T. J. Webster
On-demand Immunomodulation Centers for Reducing Inflammation in Osteoarthritis........................................................................ 68Y. F. Tian, R. S. Schneider, D. Holyoak, M. C. H. Van Der Meulen, A. Singh
S-nitrosated Poly(Propylene Sulfide) Nanoparticles Exhibit Thiol-Dependent Transnitrosation and Toxicity Against Adultfemale B. Malayi Filarial Worms ........................................................................................................................................... 69
A. Schudel, S. Thomas, T. Kassis, B. Dixon
Nanoparticle Mediated Delivery of Glutamate Enhancers to Restrain Autoimmune Reactions ............................................................ 70J. M. Gammon, L. H. Tostanoski, Y. Chiu, C. M. Jewell
Development of a Cytokine-Loaded Layer by Layer Coating on Polypropylene Meshes to Modulate Macrophage Polarization at the Tissue-Implant Interface................................................................................................................................................. 71
D. Hachim, S. T. Lopresti, B. N. Brown
Polymersome-templated Porous and Hollow Nanogels for Dual Intracellular Delivery.......................................................................... 72F. Du, E. A. Scott
Modulation of the Immune Response Via the NF-kB Signaling Pathway in Rheumatoid Arthritis in Vitro Models .......................... 73P. R. Wardwell, R. A. Bader
MACROMOLECULAR DRUG DELIVERY Inhalable Dry Powder Microparticles for Delivery of Bacteriophages to Treat Cystic Fibrosis Associated Bacterial Lung Infections ................................................................................................................................................................................................. 74
R. Agarwal, C. Johnson, A. J. Garcia
Intracellular Trafficking of Alginate-graft-Poly (Ethylene Glycol) Microspheres for Promoting Mesenchymal Stem Cell Osteogenic Differentiation ....................................................................................................................................................................... 75
T. Miao, R. A. Oldinski
Cholera Toxin Subunit B-Modified Mesoporous Silica Nanoparticles as Vehicles for the Improved Intracellular Delivery of Proteins .......................................................................................................................................................................................... 76
W. A. Walker, J. L. Vivero-Escoto
Reactive Oxygen Species (ROS)-responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy ................................................................................................................................................................................................ 77
Q. Xu, M. Wang
Bioorthogonal Hyaluronate Hydrogels for Therapeutic Protein Delivery................................................................................................. 78A. Famili, J. G. Aaronson, K. Rajagopal
Self-Assembled Tannin Complexes for Redox Responsive Drug Delivery ................................................................................................ 79H. A. Cheng, C. T. Drinnan, E. Yoo, A. L. Doiron, O. Z. Fisher
Controlled Local Delivery of Therapeutic Antibodies from Injectable Hydrogels ................................................................................... 80N. A. Fletcher, M. D. Krebs
pH-Responsive Polymeric Vehicles for the Oral Delivery of Hemophiliac Factor IX .............................................................................. 81S. D. Horava, N. A. Peppas
MULTISCALE BIOMATERIAL DESIGN A Generalized Large Deformation Structural Constitutive Model for Forming Tissues in Needled Non-woven Scaffolds............................................................................................................................................................................................................. 82
M. S. Sacks
Carbon Nanotube-Based Bio-impedimetric Bone Marker Sensors ............................................................................................................ 83M. S. Patil, M. Ramanathan, V. Shanov, P. N. Kumta
Synthesis of Large Pore Sized Mesoporous Silica Nanoparticles Embedded with Magnetic Nanoparticles for Loadingof Large Sized Molecules ................................................................................................................................................................... 84
B. G. Cha, J. Kim
A Protease-Activatable Nanoparticle Contrast Agent for Molecular Imaging by Dual Energy Computed Tomography ...................................................................................................................................................................................................... 85
J. Ashton, C. Badea, J. West
Fiber Reinforced Collagen-GAG Scaffolds for Tendon Bone Junction Repair ........................................................................................ 86L. Mozdzen, R. Rodgers, J. Banks, B. A. Harley
Tissue Formation and Remodeling in Tissue Engineered Pulmonary Conduits....................................................................................... 87M. S. Sacks
NANOBIOMATERIAL AND DRUG DELIVERY STRATEGIES FOR DENTAL/CRANIOMAXILLOFACIAL REPAIR/REGENERATION Improved Mechanical Properties of 3D Printed Calcium Phosphate Scaffolds for Craniofacial Reconstruction................................ 88
J. Vella II, R. Trombetta, M. Hoffman, J. Inzana, H. Awad, D. Benoit
Partially Demineralized Macroporous (PDM) Allografts for Cranial Tissue Engineering ..................................................................... 89A. M. Emmakah, H. Arman, R. Almousa, N. Bhimireddy, S. Musgrove, J. Syed, A. Tovar, C. Wunderlin, T. G. Chu
Evaluation of Two Types of Chitosan Nanofiber and Collagen Membranes in Critical Size Rat Calvarial Defect ............................. 90H. Su, K. Liu, D. Abebe, C. Wu, A. Karydis, K. Anderson, P. Adatrow, T. Fujiwara, W. Haggard, J. Bumgardner
In Vitro Degradation and Physical Characterization of Antimicrobial Electrospun Polyurethane Scaffolds ...................................... 91M. E. E. Wright, M. Yang, P. Santerre
High Throughput Genotoxicity Assay of Nanomaterials with Single Cell Halochip Assay ..................................................................... 92Y. Qiao, L. Ma
Synthesis of Antimicrobial Di-Vinyl Monomers for Dental Restorative and Adhesive Systems............................................................. 93Y. Delaviz, M. A. Nascimento, M. Yang, J. P. Santerre
ORTHOPAEDIC BIOMATERIALS High Strength Magnesium-Yttrium based Alloys Exhibiting Controlled Degradation for Musculoskeletal Medical Implant Application ......................................................................................................................................................................................... 94
D. Chou, D. Hong, B. Lee, Y. Chen, Z. Xu, P. N. Kumta
Safety and Efficacy of PEEK Intramedullary Nail Fixation System using an Ovine Tibial Fracture Repair Model........................... 95M. Assad, D. Beaudry, J. Wilson, B. Lussier, M. Chagnon, E. Pluhar, M. Cantwell
Long-Term Effects of Poly (ε–caprolactone) Implantation in a Bone Defect Model ................................................................................ 96A. C. Petticoffer, A. Recber, L. Boure, D. Arens, X. Liu, M. Fulmer, R. Harten
An In Situ Forming, Injectable PLGA Composite for Orthopedic Applications ...................................................................................... 97P. Fisher, T. Milbrandt, Z. Hilt, D. Puleo
A Three Dimensional Rotating Bioreactor for the Production of Micro Engineered Bone Tissue in Large Scale-feasibility Study ................................................................................................................................................................................................ 98
A. Grottkau, B. Grottkau, Y. Pang
In Vivo Performance of Resorbable Polymer Scaffolds with Calcium Phosphate Coatings Tested in a Rabbit Critical-Sized Calvaria Model......................................................................................................................................................................... 99
J. Kim, S. McBride, O. Ortiz, M. H. R. Mango, A. Darr, J. Kohn, J. O. Hollinger
Ca2+ and cAMP Signaling in Chondrocytes is Sensitive to Hydrogel Composition and Permeability .................................................100A. E. Donius, S. V. Bougoin, J. M. Taboas
3D Printing of Scaffolds with Tunable Modulus and Pore Size for Investigating the Progression of Cancer-Induced Bone Disease In Vitro .....................................................................................................................................................................................101
U. Dadwal, J. M. Page, A. R. Merkel, M. Kessler, J. Sterling, S. Guelcher
TARGETED AND TARGET-ACTIVATED DRUG DELIVERY Bioresponsive Hydrogel Embedded Dark-gold Nanoswitch to Sense and Overcome Cancer Multidrug Resistance.........................102
N. Artzi, J. Conde, N. Oliva
Antibody-targeting of Drug-loaded Micelles to Acute Myeloid Leukemia Cells ....................................................................................103M. P. Baranello, S. Tau, D. S. W. Benoit
Structure-Inherent Targeted Contrast Agents for Parathyroid Glands ..................................................................................................104H. Hyun, M. H. Park, E. A. Owen, M. Henary, H. S. Choi
Tunable Spatiotemporal Control of Angiogenic and Osteogenic Growth Factor Delivery Via Hydrogel Encapsulation and Covalent Conjugation ...................................................................................................................................................105
M. J. Meagher, R. K. Roeder
Modular Effect on Click Chemicals for Bioorthogonal Ligation ..............................................................................................................106J. H. Lee, H. Koo, K. Bao, G. Park, S. H. Yun, H. S. Choi
Human Fetuin-A Treatment for Demineralization of Arteriosclerosis ....................................................................................................107J. L. Cunningham, E. S. Vasquez, K. B. Walters, C. L. Simpson
Development of a Novel Targeted Microparticle Drug Delivery System for Cancer Medication.........................................................108T. Dorney, C. Clark, N. Comolli
Dendrimers For Local, Targeted And Selective Treatment Of Breast Cancer .......................................................................................109N. Oliva, M. Atilano, E. Edelman, N. Artzi
BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) 2 Computer Aided Biomanufacturing of Protein Scaffolds with Controlled Macroporosity ...................................................................110
A. Islam, K. Chapin, M. Younesi, O. Akkus
Supramolecular, Guest-Host Hydrogels for 3D Bioprinting of Material and Cellular Structures .......................................................111C. B. Highley, C. B. Rodell, J. A. Burdick
A Multi-Material Bioink Method for 3D Printing Tunable and Cell-Compatible Hydrogels ...............................................................112A. L. Rutz, K. E. Hyland, A. E. Jakus, W. R. Burghardt, R. N. Shah
Bioprinted Liver Organoid for Toxicology Testing ....................................................................................................................................113H. Kang, S. J. Lee, A. Skardal, I. Mead, M. Devarasetty, T. Shupe, C. Bishop, J. Jackson, S. Soker, J. Yoo, A. Atala
3-D Bioprinting of Skeletal Muscle Tissue Constructs for Accelerated Restoration of Muscle Function ............................................114J. H. Kim, Y. Seol, I. K. Ko, H. Kang, H. S. Kim, J. S. Lee, S. J. Lee, A. Atala, J. J. Yoo
Collagen NanoFiber Coating on Cell Surfaces for Construction of Cell-Density Controlled 3D-Thick Tissues.................................115M. Matsusaki, C. Liu, M. Akashi
BIO-NANOMATERIALS FOR CANCER THERANOSTIC TREATMENT Therapeutic In Vivo RNAi-based Nanoparticle Silencing in Lung Tumor-Associated Macrophages .................................................116
J. Conde, C. Bao, Y. Tan, D. Cui, E. R. Edelman, H. S. Azevedo, H. J. Byrne, F. Tian, N. Artzi
Biodegradable Photoluminescent Nanoparticles for Immune Cell-Mediated Melanoma Targeting and Theranostic Drug Delivery ..................................................................................................................................................................................................117
Z. Xie, Y. Su, E. Selvi, G. B. Kim, V. A. Sanabria, C. Ma, C. Dong, J. Yang
Multiplexed Biomarker Detection Using Phase Change Nanoparticles ...................................................................................................118J. An, M. Su
Azole-functionalized Nanoparticles for Imaging & Drug Delivery ..........................................................................................................119R. J. Cavazos Jr., R. A. Petros
Single Cell Array Based Toxicity Assay for Personalized Medicines .......................................................................................................120Y. Qiao, L. Ma
Cancer Specific and Multicolor Bioimaging Using Triple-triplet Annihilation Upconversion Nanocapsules.....................................121H. S. Song, O. S. Kwon, J. Conde, J. Kim, N. Artzi
ENGINEERING CELLS & THEIR MICROENVIRONMENTS Scaffold Fiber Diameter and Alignment Co-Regulate Tendon Fibroblast Response .............................................................................122
W. Levine, C. Erisken, H. Lu, N. Lee
Identifying Localized Shear Forces and Nutrient Gradients in 3D Flow Perfusion MSC Cultures .....................................................123C. Williams, A. Simmons, D. Papavassiliou, R. Voronov, V. Sikavitsas
Poly(dimethyl siloxane)-Containing Nanofiber Meshes as a Platform for Studying Stem Cell Behavior............................................124D. R. Bogdanowicz, P. J. Chuang, L. C. Kam, H. H. Lu
Conducting Polymer Films with Biomolecular Gradients for Cell Adhesion Control ...........................................................................125S. Park, D. Nocera, M. R. Abidian, S. Majd
Anisotropically Stiff Micropillars as a Unidirectional Cell Entrapment and Alignment Niche for Cardiomyocytes.........................126Y. Alapan, M. Younesi, O. Akkus, U. Gurkan
Maxwell Stress Field Induced Biological Cell Deformation in an Electric Field Stimulated Medium .................................................127R. Krishnamurthy, V Kumaran, B. Basu
PC12 Cell Attachment, Proliferation, and Differentiation on Polymer Spherulites ...............................................................................128X. Wu, S. Wang
The Direction of Stretch-Induced Cell and Stress Fiber Orientation Depends on Collagen Matrix Stress .........................................129R. Kaunas, A. Tondon
LOCAL DELIVERY OF DRUGS AND GROWTH FACTORS FROM IMPLANT COATINGS Dextran Sulfate Thin Films: A Novel Drug Delivery Platform for Drug-Eluting Balloon Applications..............................................130
S. Lamichhane, G. Mani
Hydrogel Implant Coatings for Peripheral Nerve Regeneration ..............................................................................................................131D. Bhatnagar, J. Bushman, B. A. Clements, S. Murthy, J. Kohn
Porous Dexamethasone-relasing Coatings Improve the Performance of Implantable Glucose Sensors in Normal and Diabetic Rats............................................................................................................................................................................................132
S. G. Vallejo-Heligon, N. L. Brown, B. Klitzman, W. M. Reichert
Engineering Drug-eluting Coatings to Design Next Generation Devices for Locally Treat Pancreatic Cancer. ................................133L. Indolfi, M. Ligorio, D. Ting, R. Tzafriri, C. Ferrone, J. Clark, R. Langer, E. Edelman
Local Delivery of Paclitaxel Using Infusion Balloon Catheters.................................................................................................................134J. Anderson, G. Mani, T. Remund, P. Kelly, L. Danielson, M. Nykamp, K. Pohlson, R. Evans, K. Egland, M. Clark
Surface Modification of Ti with Micro/Nano Multi-scale Roughness for the Growth Factor Loaded Implant..................................135S. W. Kim, T. Jang, B. Moon, J. Song, H. Kim
Photoluminescent Antioxidant Oligomers with Potent UV-absorbing Properties..................................................................................136J. Yang, R. Van Lith, G. A. Ameer
Vancomycin Release from Point-of-care Phosphatidylcholine Implant Coatings ..................................................................................137D. Carpenter, K. Troxel, W. Haggard, J. A. Jennings
NANOMATERIALS Cellular Protease-Mediated Programmed Delivery of Anticancer Cytokine and Small-Molecule Drug.............................................138
W. Sun, T. Jiang, R. Mo, Z. Gu
Neural Cell Functionality Modulation and Bacterial Growth Deactivation on Patterned Carbon Substrates ...................................139B. Basu Sr., S. Jain Jr., A. Sharma Sr.
3D-Printed Osteo-Electro Hydroxyapatite-Graphene Composites...........................................................................................................140A. E. Jakus, R. N. Shah
Superparamagnetic Iron Oxide Nanocomposites and Autophagy Response from Macrophage Cells.................................................141C. Wu, H. Ai, L. Yang, R. Jin
Preparation of a Nano-patterned Polymer Replica for Reducing Catheter Associated Infections .......................................................142L. Liu, B. Ercan, L. Sun, T. Webster
An Anti-inflammatory Drug Delivery System Based on Chitosan/Poly-(γ-Glutamic Acid) Nanoparticles to Treat Inflammation and Degeneration of Intervertebral Disc: An Ex Vivo Study ...........................................................................................143
G. Teixeira, A. C. L. Pereira, H. Wilke, C. Neidlinger-Wilke, M. A. Barbosa, C. Neidlinger-Wilke, R. M. Gonçalves, A. Ignatius
Visualizing Structure of Bio-Functional Magnetic Nano-Particles with Analytical Electron Microscopy .........................................144J. Wang, L. Wang, A. M. Ferrie, Y. Jin
Increased Cell Functions Using BMP-7 Functionalized Rosette Nanotubes............................................................................................145G. Mi, L. Sun, A. Alsbaiee, U. Hemraz, J. Cho, H. Fenniri, T. Webster
ORTHOPAEDIC BIOMATERIALS 2 An Analysis of Corrosion Products caused by Fretting/Wear-Accelerated Crevice Corrosion on Retrieved Co-Cr-Mo Implants ....................................................................................................................................................................................................146
M. A. Di Prima, O. Vesnovsky, L. T. Topoleski, R. Hopper, C. A. Engh Jr., P. Kovacs
Development of Biodegradable Polyurethane-ureas as Gradient Scaffolds for Ligament and Tendon Repair ..................................147T. Touchet, A. Kishan, M. Detamore, E. Cosgriff-Hernandez
Effect of Recombinant Fibronectin Fragment Coating on Osseointegration of Stainless Steel Screws in Healthy and Osteoporotic Rats ...........................................................................................................................................................................................148
R. Agarwal, C. González-García, B. Torstrick, R. E. Guldberg, M. Salmeron-Sanchez, A. J. Garcia
The Novel Use of Acoustic Radiation Force to Mechanically Load Hydrogel-Encapsulated Osteoblasts for Bone Repair...............................................................................................................................................................................................................149
J. Veronick, V. Vyas, B. Huey, Y. Khan
Pilot In Vivo Evaluation of a Resorbable, Antibiotic-Eluting Bone Void Filler to Prevent Periprosthetic Joint Infection ...........................................................................................................................................................................................................150
K. D. Sinclair, A. E. Brooks, Z. Ferrell, D. W. Grainger
A Non-Weight Bearing Model of Osteoporosis for Histomorphometric and Mechanical Evaluation of Bone Repair Using Bone Graft Substitutes ........................................................................................................................................................................151
D. J. Hall, T. M. Turner, S. M. McCarthy, S. Gitelis, R. M. Urban
Growth Factor Incorporated Collagen Threads as Suturable Therapeutic for Tendon Repair ...........................................................152M. Younesi, B. Ozgur Donmez, O. Akkus
Corrosion Behavior of Ti-6Al-4V Orthopaedic Alloy Under Tensile Stress............................................................................................153P. Panigrahi, A. Poursaee, M. K. Harman
TISSUE ENGINEERING Comparison of Tissue Engineered Intestine Produced from Non-woven Polyglycolic Acid, CollaTape Collagen, and Nanofiber Poly (ε-caprolactone) Scaffolds...................................................................................................................................................154
Y. Liu, T. Rager, J. Johnson, J. Lannutti, J. Enmark, T. Nelson, G. E. Besner
Vibratory Stimulation for Anti-Fibrotic Therapy ......................................................................................................................................155S. Bae, J. S. Lee, J. L. Barth, K. Webb
Bi-Layer Silk Fibroin Grafts Support Functional Tissue Regeneration in a Rat Model of Onlay Esophagoplasty ...........................156K. Algarrahi, D. Franck, C. Ghezzi, V. Cristafaro, X. Yang, M. P. Sullivan, Y. G. Chung, D. L. Kaplan, C. R. Estrada Jr., J. R. Mauney
Integrin Activation as a Tool to Modulate Vascular Patterning ...............................................................................................................157S. Li, T. Barker, T. Segura
New Method for Evaluation of Nano-Drug Carriers by 3D-Arterial Wall Models for Atherosclerosis Treatment ...........................158P. Chetprayoon, M. Matsusaki, U. Yokoyama, Y. Ishikawa, M. Akashi
Silk-PLA Bio-composite Materials for Medical Applications ...................................................................................................................159X. Hu
The Effect of Cyclic Loading on the Material Properties of Isolated Arterial Elastin ...........................................................................160T. Topoleski, J. B. Washington III
Swelling and Rheological Characterization of Biodegradable Dextran-based Hydrogels .....................................................................161D. R. Janagam, G. L. Ndifon, T. L. Lowe
BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING Construction of iPS-Derived 3D-Cardiac Myoblast Tissues Containing Blood Capillary Network by Cell Accumulation Technique ...............................................................................................................................................................................162
Y. Amano, A. Nishiguchi, M. Matsusaki, S. Miyagawa, Y. Sawa, M. Akashi
Highly Transparent Dense Collagen Sheets for Corneal Tissue Engineering Applications ..................................................................163R. Iyer, V. Kishore
Microribbon-like Hydrogels with Diverse Biological Cues for Forming 3D Scaffolds: a “Lego-building” approach........................164F. Yang, X. Tong, L. Han, S. Lee
Biomimetic Materials Modulate Specific Growth Factor Signaling In Vitro and In Vivo ....................................................................165D. G. Belair, M. J. Miller, A. V. Kellner, S. Wang, N. Sheibani, W. L. Murphy
Bridging the Gap: Assessing an Engineered Biomimetic Periosteum on Bone Allografts for the Reconstruction of Large Segmental Bone Defects in Mice ........................................................................................................................................................166
R. Romero, L. S. Chubb, J. K. Travers, R. Rose, A. Pennybaker, E. Asbury, N. P. Ehrhart, M. J. Kipper
Three Dimensional Multiphase Biomimetic Scaffold for Tissue Engineering Muscle-Tendon Junctions ...........................................167T. He, S. J. Lee, J. Chen, X. Tang, M. W. King
Electrospinning Degradable Hydrogel Nanofibres for Tissue Engineering............................................................................................168H. Sheardown, T. Hoare, F. Xu
Electrochemically Aligned Collagen-Elastin Fibers for Vascular Tissue Engineering ..........................................................................169T. Nguyen, C. A. Bashur, V. Kishore
CARDIOVASCULAR BIOMATERIALS 2 EPC Capturing Technology for Improving Patency of Small-diameter (2mm ID) and Long (30 Cm Length) Acellular Blood Vessels ..................................................................................................................................................................................170
T. Yamaoka, S. Somekawa, M. Kitai, Y. Ohya, Y. Kimura, T. Fujisato, A. Mahara
Hemocompatibility of Crosslinked or Thrombomodulin-modified Decellularized Matrix ...................................................................171J. J. Glynn, E. G. Polsin, M. T. Hinds
Peptide-grafted Hydrogels to Capture Endothelial Progenitor Cells under Shear for Endothelialization..........................................172W. J. Seeto, E. A. Lipke
Mechanocompatible Polymer-Extracellular Matrix Composites for Vascular Tissue Engineering.....................................................173B. Jiang, J. Wertheim, G. Ameer
Catheters Prepared with Nitric Oxide (NO) Releasing Lumen for Improved Hemocompatibility ......................................................174E. J. Brisbois, H. Handa, T. C. Major, J. Wu, J. Brownstein, C. Xi, M. E. Meyerhoff, R. H. Bartlett
Syndesomes Microencapsulated in Alginate for Revascularization in Peripheral Ischemia .................................................................175S. Das, G. Singh, A. J. Monteforte, M. E. Martinez, C. S. Wright, P. E. Martin, A. K. Dunn, A. B. Baker
3D Structured Biomaterials to Induce Vascularization after Ischemic Cardiovascular Events. ..........................................................176F. Munarin, K. Coulombe
Platelet-inspired Biomaterials Engineering for Synthetic Intravenous Hemostat ..................................................................................177A. Sen Gupta, C. Modery-Pawlowski, C. Kos, A. Anselmo, S. Mitragotri
CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Effect of Tricalcium Phosphate-based Paste- and Foam-like Bone Grafting Materials on Bone Regeneration and Osteogenic Marker Expression In Vivo .......................................................................................................................................................178
M. Lopez Heredia, D. Barnewitz, A. Genzel, F. Peters, A. Kuhr, B. Stang, W. Huebner
Fabrication of Porous Carbonate Apatite and Its In Vivo Evaluation.....................................................................................................179K. Ishikawa, N. X. T. Tram, K. Tsuru
Phage-derived Peptides Improve hBMSC Adhesion Contact Distribution and Proliferation on Biomimetic Apatite.......................180H. Ramaraju, D. H. Kohn
Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering....................................................181S. S. Chen, J. Kohn
Anti-cancer and Anti-microbial Selenium Nanoparticle Bone Scaffolds .................................................................................................182M. Stolzoff, T. J. Webster
Simvastatin-Releasing Calcium Sulfate and Calcium Phosphate Bioceramics .......................................................................................183Y. Gu, B. R. Orellana, D. A. Puleo
Effect of Mannitol Porogen Addition on Magnesium Phosphate Cements..............................................................................................184N. J. Ostrowski, B. Lee, A. Roy, P. Kumta
Twinning Induced Enhancement of Fracture Toughness in Ultra-fine Grained Hydroxyapatite-Calcium Titante Composites ......................................................................................................................................................................................................185
R. Krishnamurthy, P. K. Mallik, S. Pramanik, S. Suwas, K. Balani, B. Basu
DELIVERY OF NUCLEIC ACIDS AND OTHER MOLECULES THAT MODULATE GENE EXPRESSION NF-κB Decoy Oligodeoxynucleotide Increases Bone Mineral Density in the Murine Femur during Continuous Infusion of Polyethylene Particles.................................................................................................................................................................186
T. Lin, T. Sato, J. Pajarinen, C. Fan, F. Loi, R. Zhang, Z. Yao, K. Egahishira, S. Goodman
Elucidating Structure-Function Relationships of Poly(β-amino ester)s for Non-viral Gene Delivery via Principal Component Analysis.......................................................................................................................................................................................187
C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, J. J. Green
Surface-associated DNA Presentation for Sustained Gene Delivery with Porous Hyaluronic Acid Hydrogels ..................................188N. F. Truong, T. Segura
Porous Silicon Nanoparticle Delivery of Peptide Nucleic Acid Anti-MicroRNA Therapeutics ............................................................189K. R. Beavers, J. W. Mares, S. M. Weiss, C. L. Duvall
Nanoceria-miRNA As a Modulator of Inflammation in Diabetic Wounds..............................................................................................190I. Kalashnikova, J. Xu, S. Das, C. Zgheib, K. W. Liechty, S. Seal
Conjugation of Palmitic Acid Improves Potency and Longevity of siRNA Delivered via Endosomolytic Polymer Nanoparticles ..................................................................................................................................................................................................191
S. M. Sarett, K. V. Kilchrist, M. Miteva, C. L. Duvall
CXCR4-Overexpressing Adipose-derived Stem Cells Enhanced Brain Tumor Tropism In Vitro.......................................................192X. Jiang, C. Wang, F. Yang
Photocleavable Hydrogels for Light-Triggered siRNA Release ................................................................................................................193C. T. Huynh, M. K. Nguyen, G. Y. Tonga, V. M. Rotello, E. Alsberg
HARNESSING BIOMATERIALS TO ENGINEER THE ADAPTIVE RESPONSE FOR IMMUNITY OR TOLERANCE Determining the Specificity of a Multivalent Polymeric Antigen-Specific Immunotherapy for Multiple Sclerosis ...........................194
B. L. Hartwell, J. O. Sestak, B. P. Sullivan, H. Shinogle, C. Berkland
Intra-Lymph Node Delivery of Biomaterial Depots Prevents and Reverses Experimental Autoimmune Encephalomyelitis...........................................................................................................................................................................................195
L. H. Tostanoski, Y. Chiu, J. M. Gammon, C. M. Jewell
Current Translation Efforts for a Microparticle-based Vaccine Against Type 1 Diabetes ...................................................................196J. Lewis, M. Carstens, N. Dolgova, G. Marshall, S. Morshed, C. Xia, M. Clare-Salzler, B. Keselowsky
Anti-Cytokine Responses Elicited by Self-assembling Peptide Vaccines .................................................................................................197C. Mora Solano, R. Pompano, J. Collier
Tuning CD8+ T cell Multifunctionality with Peptide Self-assemblies.......................................................................................................198C. B. Chesson, R. J. Nusbaum, J. J. Endsley, J. S. Rudra
Electrospun Poly(dimethyl siloxane)-based Meshes as a Platform for T Cell Expansion ......................................................................199A. Dang, S. De Leo, D. Bogdanowicz, H. Lu, L. Kam
MULTIFUNCTIONAL NANOMATERIALS FOR ENGINEERING COMPLEX TISSUES AND DRUG DELIVERY Collagenase Delivery from Multi-Polymer Fibrous Scaffolds To Promote Cellular Mobility and Meniscus Repair.........................200
J. L. Holloway, F. Qu, I. L. Kim, R. L. Mauck, J. A. Burdick
Nanoengineered Bioactive Hydrogels for Cells-based Tissue Engineering..............................................................................................201J. R. Xavier, T. Thakur, P. Desai, A. K. Gaharwar
Fluorogen-Activating Proteins as Retention Modules for Local Deposition of Antibodies ...................................................................202W. S. Meng, W. Liu, M. Saunders, A. Waggoner
Engineering Micropores in Nanoparticle-bacterial Cellulose Scaffolds using a Laser-cutting Instrument: Preparation, hMSCs Proliferation and Osteogenic Differentiation for Bone Tissue Regeneration .....................................................203
P. M. Favi, S. P. O. Alvarez, T. J. Webster
Self-Assembly of Highly Asymmetric Polypeptide Amphiphiles ..............................................................................................................204I. Weitzhandler, J. R. McDaniel, S. Prevost, M. Gradzielski, A. Chilkoti
Investigation of Dendrimer-based Nanoparticles Cellular Uptake and Cell Tracking in a Semi-automated Microfluidic Platform ....................................................................................................................................................................................205
M. R. Carvalho, J. Mano Sr., R. L. Reis, J. M. Oliveira Sr.
Designing Recombinant Baculovirus/Nanomaterial based Hybrid Hydrogels for Gene Delivery Application...................................206A. Paul Jr., W. Shao, R. M. Waters, S. Prakash
Folate-functionalized Polymeric Micelle for Combinatorial Therapy to Overcome Drug Resistant Breast Cancer .........................207J. S. Lee, G. Temples
STEM CELL AND BIOMATERIAL INTERACTIONS Integrin α2β1-Specific Hydrogels Enhance Human Mesenchymal Stem Cell Survival and Bone Repair in Vivo .............................208
A. Y. Clark, A. J. Garcia
In Situ Vascularization of Injectable Fibrin/Poly(Ethylene Glycol) Hydrogels by Human Amniotic Fluid Stem Cells ..................................................................................................................................................................................................................209
O. M. Benavides, A. R. Brooks, S. Cho, J. Petsche Connell, R. Ruano, J. G. Jacot
Engineering 3D Sliding Hydrogels with Mobile Molecular Ligands to Direct Stem Cell Differentiation............................................210X. Tong, F. Yang
Disruption of Cell-Cell Contact-mediated Notch Signaling via Hydrogel Encapsulation Reduces Mesenchymal Stem Cell Chondrogenic Potential................................................................................................................................................................211
A. Chen, M. Hoffman, C. Chen, A. D. Shubin, D. S. Reynolds, D. S. W. Benoit
Heparin Cell Coating Maintains Cell Number During Mesenchymal Stem Cell Aggregate Culture ..................................................212J. Lei, J. S. Temenoff
Direct Hydrogel Encapsulation of Pluripotent Stem Cells Enables Formation of Engineered Cardiac Tissues.................................213P. Kerscher, I. C. Turnbull, A. J. Hodge, J. Kim, D. Seliktar, C. J. Easley, K. D. Costa, E. A. Lipke
ACADEMIC- INDUSTRY COLLABORATIONS IN BIOMATERIALS RESEARCH High Temperature Aging of Polyurethanes in the Prediction of In Vivo Biostability ............................................................................214
T. Touchet, N. Sears, E. Tkatchouk, C. Jenney, E. Cosgriff-Hernandez
Assessment of Antimicrobial Treatment on Cotton and Polyester Compression Bandages..................................................................215T. He, C. Augilar, B. Rose, N. Lamba, M. King, R. Jindani
Effect of Terminal Sterilization on Bioresorbable Tyrosine Derived Polycarbonates for Medical Device Applications.....................................................................................................................................................................................................216
D. Bhatnagar, V. B. Damodaran, K. Dube, G. Subramanian, S. Murthy, K. Aston, F. Halperin, M. Mao, K. Pricer, D. I. Devore, J. Kohn
Rheologically Modified Methoxypropyl-Based Cyanoacrylate Tissue Adhesives: A Preliminary Study ............................................217K. J. Garcia, J. T. Corbett, K. J. L. Burg
ADVANCES IN OPHTHALMIC BIOMATERIALS The Monthly Eye Drop: Preclinical Testing of Long-term, Hydrogel/Microsphere Eye Drops for Glaucoma..................................218
M. V. Fedorchak, I. P. Conner, J. S. Schuman, S. R. Little
Nanofibrous Scaffolds for Orderly Corneal Wound Healing ....................................................................................................................219A. Fu, G. Tae, J. A. Kornfield
Development of Biomimetic Materials for Sutureless Ocular Surface Repair ........................................................................................220C. Tison, L. Costella, A. Eiseman
A Synthetic Hydrogel Scaffold to Mimic the Bruch's Membrane for Retinal Tissue Engineering.......................................................221C. White, R. M. R. Olabisi
ADVANCES IN PROGRAMMABLE BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE Towards Degradable Protein Patterns for the Characterization of Temporal Stem Cell Behavior .....................................................222
B. Almeida, A. Shukla
Phase Behavior of Smart Peptide Polymers Shows Remarkable Tolerance to Structured Domains ...................................................223S. Roberts, J. Li, F. García Quioroz, T. Oas, A. Chilkoti
Light-triggered In Vivo Activation of Adhesive Peptide Regulates Cell Adhesion and Vascularization of Biomaterials ....................................................................................................................................................................................................224
J. R. Garcia, T. Lee, J. Paez, A. Singh, E. A. Phelps, S. Weiss, Z. Shafiq, A. Shekaran, A. Del Campo, A. J. Garcia
Improving Transdermal Drug Delivery Using Gellan Gum Hydrogels and Temperature Responsive Nanospheres ........................225C. A. Carmona-Moran, O. Zavgorodnya, S. L. Bridges, Jr., R. W. Hergenrother, J. Murphy-Ullrich, B. Ntsikoussalabongui, A. D. Penman, E. Kharampieva, T. M. Wick
A Sustainable Material for Capturing and Killing Circulating Tumor Cells .........................................................................................226S. Li, N. Chen, E. Richards, Y. Wang
Tuning Stiffness of Cell-laden Hydrogel by Photo-reversible Host-guest Interactions ..........................................................................227H. Shih, C. Lin
DENTAL/CRANIOFACIAL Development of Customized Patient-Specific Cranio-maxillofacial Scaffolds Fabricated by Binder-Jetting 3D Printing of Biodegradable Fe-based Alloys .................................................................................................................................................228
D. Hong, D. Chou, I. Issaev, A. Roy, P. N. Kumta
Local Delivery of rhBMP-2 from a Compression-Resistant Graft in a Canine Lateral Ridge Augmentation Model ........................229A. D. Talley, K. N. Kalpakci, K. J. Zienkiewicz, D. L. Cochran, S. A. Guelcher
Osseointegration of 3D Titanium Alloy Implants Fabricated by Additive Manufacturing and Etched to Create a Microstructured Surface ...............................................................................................................................................................................230
D. J. Cohen, A. Whitehead, S. L. Hyzy, G. Yachkir, M. Aviram, B. D. Boyan, Z. Schwartz
Synthesis and Characterization of a Novel Polymerizable Amine Co-Initiator for Dental Application: Evaluation of Polymerization Kinetics and Quantification of Leachables ..................................................................................................................231
Q. Ye, X. Ge, L. Song, F. Abedin, P. C. Burris, C. B. Tamerler, A. Misra, C. L. Berrie, J. S. Laurence, P. Spencer
Effect of Recrystallization Heat Treatment on Flexural Strength and Aging Resistance of Zirconia.................................................232I. Denry, O. Goudouri, J. Holloway
Development of Bioactive Dental Nanomaterials for Anticaries Therapy ...............................................................................................233M. A. S. Melo, M. D. Weir, L. C. Chow, H. H. K. Xu
IMMUNOMODULATION IN REGENERATIVE MEDICINE In Vitro Modulation of Macrophage Behavior by Ceramic-based Scaffolds ..........................................................................................235
P. L. Graney, S. Roohani-Esfahani, H. Zreiqat, K. L. Spiller
Using Amniotic Membrane Matrix to Alter the Inflammatory Response in Collagen-based Scaffolds for Tendon Regeneration ...................................................................................................................................................................................................236
R. A. Hortensius, B. A. Harley
Immunostimulatory Peptide Biomaterials as Scaffolds for Defect Repair ..............................................................................................237Y. Vigneswaran, H. Han, J. Handley, T. Sun, J. Collier
Scaffolds Engineered to Release TGF-β1 Improve Islet Graft Function .................................................................................................238R. M. Gower, J. Zhang, J. M. Liu, X. Zhang, L. D. Shea
Utilizing PEG Hydrogels to Investigate the Role of Macrophage Phenotype on Vascular Development ............................................239E. Moore, J. L. West
Biomaterial-based Microparticle Vaccine Modulates Cellular Tolerance in Type 1 Diabetes..............................................................240J. M. Stewart, J. S. Lewis, B. G. Keselowsky
MATERIALS AND MATRICES FOR OSTEOCHONDRAL TISSUE ENGINEERING In Vivo Evaluation of Bilayered Silk/Silk-Nano CaP Scaffolds for Osteochondral Regeneration........................................................241
J. M. Oliveira Sr., L. Yan Sr., J. Silva-Correia, C. Vilera, H. Pereira, R. A. Sousa, A. L. Oliveira, R. L. Reis
Hypothermically Stored Human Amniotic Membrane Allograft as a Substrate for Articular Cartilage Regeneration ...................................................................................................................................................................................................242
J. B. Vines, H. P. Walthall Jr., H. Jun
Developmentally Inspired Zone-Specific Chondrogenic Differentiation of Human Mesenchymal Stem Cells...................................243E. Jabbari
Novel Biointegrative Cross-linked Degradable Polyurethane Scaffold for Cartilage Repair................................................................244H. Liang, A. Datta, D. Grande, L. Lavelle
Mesenchymal Stem Cell Pellet Delivery Platform for Functional Repair of Cartilage ..........................................................................245M. Younesi, A. Islam, V. M. Goldberg, O. Akkus
Sympathetic Nerve-Like PC12 Cells Alter Osteoblast Phenotype in the Context of Osteoarthritis .....................................................246J. D. Erndt-Marino, M. S. Hahn
MODULATING THE NEURAL MICROENVIRONMENT Priming Neural Stem Cell Transplants to Dynamically Respond to Brain Injury Induced SDF-1α Gradients .................................247
C. P. Addington, J. M. Heffernan, C. Millar-Haskell, E. Tucker, R. Sirianni, S. Stabenfeldt
Poly(Ethylene Glycol) Diacrylate (PEGDA) Multiluminal Scaffold for Spinal Cord Repair Functionalized with Layer-by-layer Controlled Protein Release .................................................................................................................................................248
D. Shahriari, D. A. Lynam, Y. Koffler, M. Tuszynski, J. S. Sakamoto
Modulating Stromal Derived Factor-1α Release from Nanoparticles Via Affinity-Based Matrices ....................................................249D. Dutta, C. Fauer, S. Stabenfeldt
Integrating Low Level Light Therapy with 3D Printed Scaffolds for Improved Neural Tissue Regeneration ...................................250C. M. O'Brien, J. K. George, V. Sorger, L. G. Zhang
TECHNOLOGY DEVELOPMENT / NEW BIOMATERIALS FOR IMMUNE ENGINEERING Artificial Antigen Presenting Cells for Tumor Immunotherapy: Shape and Size Matter .....................................................................251
J. J. Green, R. A. Meyer, R. S. Meyer, J. Sunshine, K. Perica, A. Kosmides, K. Aje, J. P. Schneck
Immunomodulatory Material for the Attenuation of Multiple Sclerosis .................................................................................................252A. Thomas, J. L. Blanchfield, B. Evavold, J. Babensee
Dendritic Cell Microarrays for Screening Immunomodulatory Compounds in the Development of Tolerogenic Vaccines ...........................................................................................................................................................................................................253
M. Carstens, B. Keselowsky, A. Acharya, J. Lewis
Design of Polyelectrolyte Multi-layer Vaccines Assembled from Immune Signals on Gold Nanoparticle Templates .......................254P. Zhang, Y. Chiu, J. M. Gammon, J. I. Andorko Iv, C. M. Jewell
ADVANCED ANTIMICROBIAL MATERIALS Bacteriophage Encapsulation in Poly(Ethylene Glycol) Hydrogels Significantly Reduces Bacteria Numbers in an Implant-Associated Infection Model of Bone Repair .................................................................................................................................255
C. T. Johnson, N. Dinjaski, M. Auxiliadora Prieto, A. J. Garcia
Tunable Antibacterial Gellan Hydrogels for Burn Wounds .....................................................................................................................256S. Shukla, A. Shukla
Click Chemistry and Implantable Biomaterial for Local Enhancement of Systemic Small Molecules ...............................................257J. M. Mejia Oneto, M. Gupta, J. K. Leach, L. Lindsay, J. Sykes, M. Royzen
Platelet Adhesion and Bacterial Adhesion on PEG-Modified Textured Biomaterial Surfaces .............................................................258L. Xu, C. A. Siedlecki
Chitosan Immobilized Titanium Surface in Co-Culture System ..............................................................................................................259B. Foss, Y. Sun, Y. Deng
Surface Modification by Antibiotic-Loaded Microgels Inhibits Bacterial Colonization........................................................................260J. Liang, Y. Wu, M. Libera
Ionic Liquids Deliver Antibiotic Into Skin and Neutralize Biofilm-Protected Pathogens......................................................................261M. Zakrewsky, K. S. Lovejoy, T. L. Kern, T. E. Miller, V. Le, A. Nagy, A. M. Goumas, R. S. Iyer, R. E. Del Sesto, A. T. Koppisch, D. T. Fox, S. Mitragotri
Removal of Drug-Resistant Bacteria and Ebola Virus from Whole Blood with a Sorbent Hemoperfusion Device: Carbapenum-Resistant Enterobacteriaceae ................................................................................................................................................262
R. S. Ward, K. M. McCrea
BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Micropatterning Directional Extracellular Matrix Cues in Hydrogel-based Scaffolds for Cardiac Tissue Engineering .....................................................................................................................................................................................................263
Q. Jallerat, V. S. Palayekar, A. W. Feinberg
Single-step Chemistry to Independently Control Matrix Stiffness and Conjugation of Pro-angiogenic Peptides..............................264L. Cai, S. Heilshorn, C. Dinh
Sequential Delivery of VEGF165 and PDGF-BB to Repair Myocardial Infarction ...............................................................................265H. K. Awada, Y. Wang
Biomimetic Micropatterns Based on the Embryonic Heart for 2D Cardiac Tissue Engineering .........................................................266I. Batalov, S. Kim, Q. Jallerat, A. W. Feinberg
Hydrogels to Support 3D Microvessel Formation by Blood-derived Endothelial Progenitor Cells .....................................................267E. Brown Peters, N. Christoforou, K. W. Leong, G. A. Truskey, J. L. West
Assessing the Calcification Potential of Engineered Vascular Grafts with Surface Enhanced Raman Spectroscopy........................268K. R. Kerney, N. Roki, M. Fenn, C. Bashur
Promoting Neonatal Cardiomyocyte Proliferation Using a Cryptic Matrikine Derived from Fibrillin-1 ...........................................269K. J. Edmunds, J. S. Weinbaum, L. D. Black III, C. Williams
Temporal Regulation of GSK3/Wnt Signaling Molecules within a 3D Gelatin/chitosan Scaffold Promoting Cardiac Differentiation of Amniotic Fluid Derived Induced Pluripotent Stem Cells for Congenital Heart Defect Repair .............................270
C. Tsao, S. Pok, A. Velasquez-Mao, J. Jacot
INJECTABLE BIOMATERIALS FOR TISSUE REGENERATION Injectable Gelatin Derivative Hydrogels with Sustained Vascular Endothelial Growth Factor Release for Induced Angiogenesis ....................................................................................................................................................................................................271
Z. Li, X. H. Liu
In Situ Cross-linkable Gelatin Hydrogels for Vasculogenic Delivery of Mesenchymal Stem Cells ......................................................272S. H. Lee, Y. Lee, P. P. Young, K. D. Park, H. Sung
Injectable Dual-Crosslinking Hydrogels to Decouple Material Retention and Mechanical Properties In Vivo .................................273C. B. Rodell, J. W. Macarthur Jr., R. J. Wade, S. M. Dorsey, J. A. Burdick
Smooth Muscle Cells on Photo-cured Poly(ε-caprolactone) Substrates with Varied Stiffness and Micro-grooves ............................274J. Dou, S. Wang
Subretinal Injection of Micropatterned Nanosheets for Effective Cell Delivery ....................................................................................275H. Kaji, Y. Mori, T. Fujie, N. Nagai, T. Abe
Strong Injectable Thermosensitive Scaffolds for Cell Therapy ................................................................................................................276C. Ceccaldi, E. Assaad, L. Bonneton, S. Lerouge
Injectable Microporous Scaffolds from Annealed Building Blocks for Accelerated Wound Healing ..................................................277D. R. Griffin, W. M. Weaver, P. Scumpia, D. Dicarlo, T. Segura
Mineralization and Bone Regeneration of Injectable, Dual-Gelling Hydrogel-Cell Constructs ...........................................................278T. N. Vo, S. R. Shah, S. Lu, E. J. Lee, A. M. Tatara, A. G. Mikos
MECHANICAL CHARACTERIZATION OF BIOMATERIALS Tensile Mechanical Property Evaluation of Two Absorbable Sutures: Effects of Size and Types .......................................................279
N. D’Aversa, D. Burkley, L. Vailhe, M. Deng
Experimental and Computational Study of Process-Property Relationships for Bioabsorbable Polymers ........................................280C. R. Gajjar, B. Singhi, M. A. Pasquinelli, M. W. King
Strengthening of Ti-6Al-7Nb Alloy for Dental Narrow Implants .............................................................................................................281T. Hanawa, M. Ashida, P. Chen, H. Doi, Y. Tsutsumi, Z. Horita
Improving Fatigue and Fracture Resistance of 45S5 Bioactive Glass/Polyurethane Biocomposites for Repairing Bone Defects ....................................................................................................................................................................................................282
A. J. Harmata, S. Uppuganti, S. A. Guelcher, J. S. Nyman
Tailoring the Mechanical Characteristics of PEG-based Hydrogels for the Production of High-performance Soft Tissue Expander .............................................................................................................................................................................................283
M. Jamadi, P. Shokrollahi, B. Houshmand, M. Daliri
Burst Properties and Adhesion Strength of Oxidized Methacrylated Alginate Lung Sealants.............................................................284P. Charron, A. Poniz, S. Fenn, D. Weiss, R. Oldinski
Relevance of the Spatial Distribution Pattern of Mechanical Properties of Articular Cartilage in Animal Studies ..........................285S. Sim, I. Hadjab, M. Garon, E. Quenneville, M. D. Buschmann
Characterization of Soft Tissue Transmural Microstructure ...................................................................................................................286J. G. Lesicko, K. R. Feaver, M. S. Sacks
RECENT ADVANCES IN SURFACE MODICATION OF MIOMATERIALS 2 Surface Modification of Ceramic Biomaterials After In Vivo Exposure to the Physiological Environment .......................................287
A. Wusylko, K. Kornev, M. Harman
Biological Tethering of N-Cadherin to Substrates Promotes Cell-Cell Adhesion ...................................................................................288J. Vega, M. K. Lee, D. E. Leckband, H. Kong
Organic-Inorganic Hybrid Coating for Deformable and Biioactive Magnesium Implants ...................................................................289G. Cheon, J. Song, S. Kim, M. Kang, H. Kim
Glow-discharge RF Plasma Polyether and Fluoropolyether Substrates Prevent Protein Adsorption .................................................290M. Mecwan, B. Ratner
Rapid Coating of AZ31 Magnesium Alloy with Calcium Deficient Hydroxyapatite Using Microwave Energy .................................291Y. Ren, H. Zhou, S. Bhaduri
Bioinspired Hydrogels for Transfer Printing of Ultracompliant Medical Electronics ..........................................................................292H. Wu, C. Zhu, C. Bettinger Jr.
Life-long Durability of Orthopedic Bearings by Phospholipid Polymer Grafting and Antioxidant Blending ....................................293M. Kyomoto, T. Moro, S. Yamane, K. Watanabe, K. Ishihara
Hydroxyapatite/Poly(Ether Imide) Micro-patterned Protective Coating on Magnesium for Biomedical Applications.....................................................................................................................................................................................................294
S. Kim, J. Song, M. Kang, G. Chun, H. Kim
SMALL MOLECULE DRUG DELIVERY Sustained Release of Short Peptides Using Guest-host Complex Formation in Injectable Hydrogels .................................................295
J. E. Mealy, C. B. Rodell, J. A. Burdick
PEG Hydrogel Nanoparticles for Controlled Release of Angiogenic Peptides ........................................................................................296D. A. Young, G. Papavasiliou
Synthesis of Protein-polymer Conjugates with Controllable Properties .................................................................................................297H. Chen, L. Wang, X. Li, L. Yuan, H. Wang, G. Chen
Injectable In Situ Forming Depot Systems for Long Acting Contraception ...........................................................................................298D. R. Janagam, L. Wu, K. Chaudhry, T. D. Mandrell, J. R. Johnson, T. L. Lowe
Design and Construction of Hypoxically Activated Drug Release System...............................................................................................299Y. Ikeda, H. Hisano, Y. Nagasaki
Gap Junction Liposomes for Direct Therapeutic Delivery to the Cellular Cytoplasm ..........................................................................300D. J. Busch, J. Stachowiak
Amorphous Magnesium Phosphate Nanoparticles As Nonviral DNA Carriers .....................................................................................301M. Nabiyouni, S. B. Bhaduri
Scaffolds with Incorporated Photo-Carbon Monoxide Releasing Materials for Engineering Vascular Grafts ..................................302E. K. Michael, N. Abeyrathna, K. Birthare, Y. Liao, C. Bashur
STEM CELL AND BIOMATERIAL INTERACTIONS 2 Towards Engineering a Multi-Niche Functional Human Bone Marrow: Advancing Basic Studies and Aiding Clinical Translation........................................................................................................................................................................................303
M. R. Nelson, K. Bai, K. Roh
3D Stem Cell Morphotyping of Tissue Engineering Scaffold Niches .......................................................................................................304S. J. Florczyk, M. Simon, D. Juba, S. Sarkar, D. Chen, P. J. Baker, A. Cardone, M. Brady, P. Bajcsy, C. G. Simon Jr.
Eliminating Dexamethasone from Osteogenic Media Leads to the Production of Angiogenic Factors by Microencapsulated Adipose Stem Cells .......................................................................................................................................................305
Z. Schwartz, B. D. Boyan, S. K. Leslie
Multivalent Platform for Spatial Control of Arterial Venous Differentiation of Pluripotent Stem Cells ............................................306T. B. Dorsey, G. Dai
Polyethylene Glycol Hydrogels Functionalized with a Continuous Ile-Lys-Val-Ala-Val Concentration Gradient for Optimizing Neural Differentiation of Murine Embryonic Stem Cells in 2D ...........................................................................................307
L. Smith Callahan, H. Yang
Bioinstructive Scaffolds Through a Multiscale Approach Mimicking Tissue Mechanics and Regulating Differentiation .................................................................................................................................................................................................308
B. L. Banik, J. L. Brown
Maintaining the Pluripotency of Mouse Embryonic Stem Cells on Gold Nanoparticle Layers with Nanoscale But Not Microscale Surface Roughness ..............................................................................................................................................................309
Z. Lyu, H. Wang, Y. Wang, K. Ding, H. Liu, L. Yuan, X. Shi, M. Wang, Y. Wang, H. Chen
Electric Field Induced Lineage Commitment of Mesenchymal Stem Cells Towards Neural-like Cells on Conducting Polyaniline Substrates...............................................................................................................................................................310
G. Thrivikraman, G. Madras, B. Basu
2ND ANNUAL SFB BUSINESS PLAN COMPETITION Ancure, LLC: Controlled Release Solutions for Treating Brain Aneurysms..........................................................................................311
M. Cramer, A. Iftikhar, M. Horowitz, C. Bettinger
Marauder Medical Devices: Novel Lung Assist Device for Preterm and Term Neonates .....................................................................312D. Sandejas, H. Matharoo
Evoke Medical: Stimulating a Pathway to Bone Healing ..........................................................................................................................313N. Galvis, E. Cadel, H. Sis, B. Wong, P. M. Arnold, E. A. Friis
MacroTheranostics: A Macrophage-based Therapeutic and Diagnostic Wound Care Company .......................................................314S. Nassiri, K. L. Spiller
Nanochon: Novel 3D Printed Joint Repair Scaffolds .................................................................................................................................315B. Holmes, N. Castro, L. G. Zhang
OsteoInk: Bioactive Bone Cements ..............................................................................................................................................................316J. Chari, L. C. Rodriguez, D. C. Rodrigues
BIO-INSPIRED CELLULAR MICROENVIRONMENTS Selectin-mediated Cell Adhesion on Glycoprotein-conjugated Hydrogels ..............................................................................................317
Y. Iwasaki, A. Matsunaga, S. Sugimoto
Altered Extracellular Matrix Properties Drive Tumor Progression ........................................................................................................318K. Wang, M. Quien, L. Hsu, W. Lewis, C. Fischbach, D. Gourdon
PEG-fibrinogen Hydrogel Microspheres Support 3D Tumorigenic Growth of MCF7 Breast Cancer Cells ......................................319S. Pradhan, J. Clary, D. Seliktar, E. A. Lipke
Bio-inspired Lymphoid Tissues for Immune Cell Cancers........................................................................................................................320Y. F. Tian, R. S. Schneider, L. Cerchietti, A. Singh
Cell Guidance Into Quiescent State Through Chromatin Remodelling Induced by Elastic Modulus of Substrate ...........................321M. Rabineau, F. Flick, B. Senger, P. Lavalle, P. Schaaf, J. Freund, D. Vautier
Hydrogel Arrays to Screen Angiogenesis Inhibitors and Vascular Disrupting Compounds.................................................................322D. G. Belair, M. P. Schwartz, W. L. Murphy
Micro/Nano Modified Titanium Alloy Induces MSCs Osteogenesis and Reduces Inflammatory Interleukin Production .......................................................................................................................................................................................................323
R. Olivares-Navarrete, S. L. Hyzy, S. Ortman, P. Ullrich Jr., Z. Schwartz, B. D. Boyan
Bioinspired Silicate Nanocomposites for Osteoarthritis Therapy.............................................................................................................324J. Carrow, G. Lokhande, A. K. Gaharwar
BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING 2 Creating Liver-Mimicking Tissue Constructs in a 3D Biomimetic Hydrogel .........................................................................................325
H. Bearat, J. West
Surface Grafting of Chitosan-Coated Electrospun Fibers to Promote Cell Adhesion ...........................................................................326A. S. Goldstein, P. Vaidya, T. Z. Grove
A 3D Hydrogel Model of Tumor Angiogenesis to Study the Role of Vascular Cells in Tumor Progression .......................................327L. C. Roudsari, A. S. Witt, J. M. Kurie, J. L. West
Culture Platform to Assess the Effect of Hydroxyapatite Properties on Breast Cancer Cells ..............................................................328S. Choi, L. A. Estroff, C. Fischbach
Regulating Endothelial Cell Dynamics through Peptide-Encoded Material Compliance .....................................................................329R. M. Schweller, J. L. West
Biomimetic Fibrous Hydrogels with Aligned Hierarchical Structure Promote Biomineralization in Vitro........................................330A. Patel, V. Sant, S. Sant
Plastically Compressed Bioglass Incorporated Collagen Matrices for Orthopedic Applications .........................................................331G. Liu, M. B. Fenn, L. L. Hench, V. Kishore
Hyaluronic Acid Hydrogels that Emulate the Pro-osteogenic Niche Enhance the Osteogenesis of hMSCs ........................................332L. Bian, M. Zhu, Q. Feng
CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY 2 Biologically Inspired Scaffold Mimicking Trabecular Bone in a Rabbit Spinal Fusion Model ............................................................333
S. Minardi, B. Corradetti, F. Taraballi, M. Sandri, J. Van Eps, F. Cabrera, B. Weiner, A. Tampieri, E. Tasciotti
Reinforced Magnesium Phosphate Cement with Wet-spun PCL Fibers .................................................................................................334N. J. Ostrowski, V. Sharma, J. Ohodnicki, A. Roy, P. N. Kumta
Longitudinal Evaluation of Bioactive Strip Implanted into the Distal Condyle of New Zealand White Rabbits ...............................335Z. Tosun, G. Pomrink
Preparation and Characterization of Poly (hydroxybutyrate co hydroxyvalerate) Nanofibers Containing Sol-gel Derived Bredigite for Bone Regeneration Applications .............................................................................................................................336
M. Kouhi, M. Fathi, M. Shamanian, M. P. Prabhakaran, S. Ramakrishna
Release and Activity of Adenosine Incorporated Into Calcium Sulfate ...................................................................................................337E. C. Duncan, D. Carpenter, W. Haggard, J. A. Jennings
Reinforcement of Injectable Calcium Phosphate Cement by Gelatinized Starches ...............................................................................338L. Yang, H. Liu, Y. Guan, H. Yang, D. Wei, C. Gao
Hydroxyapatite-Titanium Composites with Outstanding Fracture Toughness and Cytocompatibility Properties for the Bone Tissue Engineering Applications ..................................................................................................................................................339
A. Kumar, M. Saxena, K. Biswas, B. Basu
Multifunctionality and Electrical Stimulation Induced Cellular Response of Hydroxyapatite-Barium Titanate Piezobiocomposite...........................................................................................................................................................................................340
B. Basu, A. K. Dubey, G. Thrivikraman
DRUG DELIVERY Selectively Decreasing Malignant Melanoma Cell Viability with Polymersomes Loaded with Protoporphyrin IX (PPIX) ..............................................................................................................................................................................................................341
M. Wang, B. Geilich, H. Homayoni, E. Ebong, T. Webster
Sustained Suppression of Mitochondrial Oxidative Stress using Curcumin conjugated Poly (β- Amino Esters) Nanogels...........................................................................................................................................................................................................342
P. Gupta, J. Z. Hilt, T. D. Dziubla, M. Mitov
Poly(Beta-Amino Ester) Nanoparticles for Selective and Combinatorial Delivery of siRNA to Brain Cancer...................................343K. L. Kozielski, H. Vaughan, B. H. Kim, S. Y. Tzeng, H. Guerrero-Cazares, A. Quinones-Hinojosa, J. J. Green
Photo-polymerized Keratin-PEG Sponge for Growth Factor Delivery in Bone Tissue Engineering ...................................................344R. De Guzman
ON-OFF Fluorescent Micelles as a Transdermal Drug & Vaccine Delivery System .............................................................................345D. Velluto
Modeling of Drug Release Kinetics from Porous Ceramic Disks..............................................................................................................346A. U. Joshi, H. P. Cherukuri, A. R. El-Ghannam
An Injectable and Thermosensitive Hydrogel Capable of Delivering Matrix Metalloproteinases 2 Inhibitor to Control Myocardial Remodeling ..................................................................................................................................................................347
Z. Fan, M. Fu, B. Zhang, Z. Li, X. Li, Y. Xu, J. Guan
Evaluation of Controlled Delivery of Carboplatin from a Poly-Ether-Ester Urethane System in a Murine Model...........................348D. R. Ingram, J. M. Olbrich, J. T. Corbett
ENGINEERING TISSUES INTERFACES Recapitulating the Architecture of Cells of Interest Using Cell-Derived, Biomimetic Patterning ........................................................349
J. H. Slater, J. C. Culver, B. L. Long, C. W. Hu, J. Hu, T. F. Birk, A. A. Qutub, M. E. Dickinson, J. L. West
Dose-Dependent Effects of CDA on Chondrocyte Response on Polymer-Ceramic Composite Scaffolds ............................................350M. K. Boushell, K. R. Caparino, H. H. Lu
Patterning Biochemical Signals into Nanofibrous Hydrogels to Spatially Control Cell Behavior........................................................351R. J. Wade, E. J. Bassin, W. M. Gramlich, J. A. Burdick
Mechanical Loading of 3D multi-Compartment Scaffolds for Spatial Control of hMSC Fate for Regeneration of Orthopedic Interfaces ....................................................................................................................................................................................352
W. K. Grier, S. R. Caliari, A. S. Moy, B. A. Harley
Cartilage Lubrication through Peptide-mediated Hyaluronic Acid Binding and Retention.................................................................353A. Singh, M. Corvelli, H. Jacobs, J. Elisseeff
Evaluation of Anterior Cruciate Ligament Insertion Site Fibrochondrocytes on Nanofiber Scaffolds ...............................................354D. Qu, H. Park, J. P. Zhu, H. H. Lu
Influence of Sparse Electrospun Fibers on the Differentiation of Mesenchymal Stem Cells in Collagen Gels ...................................355P. Thayer, E. Tong, N. Butler-Abisrror, A. Goldstein
Rotational Dual Chamber Bioreactor for Interfaced Engineered Tissue Models...................................................................................356R. F. Canadas, A. P. Marques, J. M. Oliveira, R. L. Reis
MOLECULAR MECHANISMS GOVERNING PROTEIN-SURFACE AND CELL-SURFACE INTERACTIONS Angiogenic Methacrylic Acid Copolymers Adsorb Different Proteins and Result in Lower Complement Activation in Comparison to Poly (Methyl Methacrylate)............................................................................................................................................357
L. A. Wells, H. Guo, A. Emili, M. V. Sefton
Factor XII Contact Activation Products Show Self-Inhibition .................................................................................................................358L. Xu, Y. Xu, E. A. Vogler, C. A. Siedlecki
Interfacial Segregation of PEG in Hydrophobic Polymers and Its Influence on Protein Adsorption ..................................................359N. S. Murthy, W. Wang, W. R. Lindemann, N. A. Anderson, D. Vaknin, J. Kohn
Influence of Chemical Additives on the Structure and Biological Activity of Proteins Pre-adsorbed on Material Surfaces Using an Improved Circular Dichroism Methodology ...............................................................................................................360
A. A. Thyparambil, Y. Wei, R. A. Latour
Molecular Insights into the Gel to Liquid-Crystalline Phase Transition of Phospholipid Bilayers ......................................................361L. Weng, G. D. Elliott
FXIIa Products Produced by Surface Contact Activation.........................................................................................................................362Y. Yan, L. Xu, C. A. Siedlecki
The Phosphoproteomics Landscape of the Interaction between Biomaterials and Cells .......................................................................363M. D. Chamberlain, L. Wells, A. Lisovsky, M. Sefton
Surface Design of Heparin-Functionalized Thermoresponsive Cell Culture Substrates for Maintaining Hepatic Functions and Harvesting Cultured Hepatocyte Sheets ............................................................................................................................364
J. Kobayashi, Y. Arisaka, K. Ohashi, K. Tatsumi, K. Kim, Y. Akiyama, M. Yamato, T. Okano
ADVANCED ANTIMICROBIAL MATERIALS 2 Assessment of Bacteriophage Activity in Poly(Ethylene Glycol) Hydrogels............................................................................................365
M. E. Díaz Ortiz, C. T. Johnson, A. J. García, M. A. Prieto, N. Dinjaski
Characterization of In-vitro Release of Gentamicin from Biodegradable Polymer Thin Films - Microstructure-Function Relationship by Confocal Raman Microscopy............................................................................................................................366
A. Pandey, D. Armbruster, L. Hughes, S. Nielsen, A. Mantz
Testing Leading to a “De Novo” (I.E., No Predicate) FDA Cleared Antimicrobial Wound Dressing ..................................................367C. Batich, G. Schultz, W. Toreki, J. Olderman, B. Mast, D. Moore, D. Mozingo, B. Liesenfeld
Silver Nanoparticle-Embedded Polymersome Nanocarriers for the Treatment of Antibiotic-Resistant Infections...........................368B. M. Geilich, A. L. Van De Ven, G. L. Singleton, S. Sridhar, T. J. Webster
Introduction of Antibacterial Function Into Biomedical TiNi Shape Memory Alloy by the Addition of Element Ag .......................369Y. F. Zheng
Examining the Amount and Form of Silver Release from Antimicrobial Medical Devices...................................................................370E. M. Sussman, P. Jayanti, B. J. Casey, B. J. Dair
Mitigation of MRSA Infection in Vivo by Dual Local Controlled Delivery of Anti-infective Agents...................................................371S. Bhattacharyya, H. Qu, N. Sheth, C. Knabe, P. Ducheyne
Bactericide Action of a Titanium Surface Biofunctionalized with a Novel Bioactive Glass ..................................................................372C. R. Chinaglia, L. A. Campanini, L. H. Pitaluga, N. S. M. Silva, C. W. O. Souza, O. Peitl, E. D. Zanotto
BIOMATERIALS FOR REGENERATIVE ENGINEERING 2 Improved Cellular Recruitment and Mass Transport for Large Bone Defect Regeneration................................................................373
S. M. Tabbaa, A. Mlynarczyk, K. J. L. Burg
Accelerated Bone Regeneration of BMP-2 Loaded Hydroxyapatite Microspheres for Bone Filler Applications ..............................374J. Baek, H. Jung, T. Jang, S. W. Kim, M. Kang, J. Song, H. Kim
Optimization of Mesenchymal Stem Cells Performance on Biomimetic Ligament Scaffolds for ACL Regeneration .......................375X. Yu, P. Mengsteab, L. S. Nair, C. T. Laurencin
Anisotropic Network Formation of Neurons and Endothelial Cells in Engineered Muscle Tissue Construct ....................................376H. Takahashi, T. Shimizu, M. Nakayama, M. Yamato, T. Okano
VEGF-Functionalized Integrin-Specific Hydrogels for Increased Stem Cell Proliferation, Vascularization and Regeneration of Critically-sized Bone Defects ............................................................................................................................................377
J. R. Garcia, A. J. Garcia
Human Plasma Based Composite Muscle ECM Directs Adipose Derived Stem Cells to Vasculogenic and Myogenic Lineage.............................................................................................................................................................................................................378
A. Aurora, R. J. Christy, T. J. Walters, S. Natesan
DRUG DELIVERY 2 Local and Sustained Drug Delivery for the Treatment of Cavernous Nerves Post-Prostate Cancer Surgery ....................................379
R. Goyal, N. Patel, A. Salmasi, I. Kim, J. Kohn
Prolonged Delivery of a P2X7R Antagonist Using an Injectable Nanostructured Hydrogel Improves Bladder Function After SCI .........................................................................................................................................................................................380
I. K. Yazdi, A. Munoz, N. Taghipour, T. B. Boone, E. Tasciotti
Nanoparticle-Engineered Adipose-Derived Stem Cells Enhanced Migration towards Brain Tumors In Vivo ..................................381X. Jiang, C. Wang, F. Yang
Click-Chemistry Customizable Polyhydroxyalkanoate Nanoparticles for Drug Delivery.....................................................................382R. A. Bader, P. M. Choiniere, A. Levine, A. Pinto, C. T. Nomura
Avidity-Driven Targeting of a Novel Biohybrid Nanoscale Carrier Engineered for High Therapeutic Payload and Extended Release of Anticancer Drugs to Treat Small Cell Lung Cancer ..............................................................................................383
R. J. Whitener, K. A. Windham, J. Wower, M. E. Byrne
Nanoparticle Delivery of a Highly Toxic Metal Chelator to Cancer Cells...............................................................................................384Y. J. Kang, C. Kuo, S. Majd
Implications Towards Targeted Delivery of Pentagalloyl Glucose for Regenerating Elastin in Emphysematous Lungs................................................................................................................................................................................................................385
V. Parasaram, N. Nosoudi, N. Vyavahare
Targeted Delivery of Antioxidant-loaded Biodegradable Nanoparticles for Neuroprotection .............................................................386T. M. Brenza, S. Ghaisas, J. Vela-Ramirez, B. Kalyanaraman, V. Anantharam, A. Kanthasamy, B. Narasimhan
INNATE IMMUNITY AND INFLAMMATION IN BIOMATERIALS CONTEXTS Local IL-4 Delivery Increases Systemic Macrophage Trafficking and Prevents Bone-loss in a Mouse Model of Wear Particle Induced Osteolysis .................................................................................................................................................................387
J. Pajarinen, T. Sato, T. Lin, F. Loi, R. Zhang, C. Fan, Z. Yao, S. Goodman
Degradation Kinetics Determine Intrinsic Immune Activity of Rapidly Degradable Polycations........................................................388J. I. Andorko, C. M. Jewell
Characterization of the Immune Response Associated with Bone Regeneration Induced by Fibrinogen Implants...........................389D. M. Vasconcelos, C. R. Almeida, R. M. Gonçalves, I. Odila, M. I. Oliveira, N. Neves, A. M. Silva, A. C. Ribeiro, E. Seebach, K. L. Kynast, T. Niemietz, W. Richter, M. Lamghari, S. G. Santos, M. A. Barbosa
Combining Human Monocytes in Co-culture with Vascular Smooth Muscle Cells Enhances Vascular Tissue Production under Biomechanical Stimulation ............................................................................................................................................390
K. Battiston, R. Labow, C. Simmons, P. Santerre
PEEK Induces an Inflammatory Environment and Reduces Osteogenic Potential in Comparison to TiAlV ....................................391R. Olivares-Navarrete, S. L. Hyzy, S. Ortman, P. J. Slosar, P. Ullrich Jr., Z. Schwartz, B. D. Boyan
Biomimetic Approaches for Tissue Healing and Restoration....................................................................................................................392E. Tasciotti, F. Taraballi, B. Corradetti, S. Minardi, L. Pandolfi, F. J. Cabrera, C. Corbo, J. L. Van Eps, X. Wang, B. K. Weiner, S. Powell
Camouflaging PLGA Microspheres in a 3D Biomimetic Collagen Scaffold to Escape Macrophage Internalization.........................393S. Minardi, B. Corradetti, F. Taraballi, S. Powell, M. Sandri, B. Weiner, A. Tampieri, E. Tasciotti
Extracellular Matrix Coatings Decrease the Foreign Body Response to Silicon Microelectrode Arrays Chronically Implanted in Rat Motor Cortex ....................................................................................................................................................................394
R. S. Oakes, M. D. Polei, J. L. Skousen, M. B. Christensen, P. A. Tresco
NEXT GENERATION BIOMATERIAL AND DRUG DELIVERY TECHNOLOGIES FOR WOUND HEALING Syndesome-Based Alginate Dressings for Enhanced Wound Healing in a Diabetic Mice Model .........................................................395
S. Das, G. Singh, M. E. Martinez, A. K. Dunn, C. S. Wright, P. E. Martin, A. B. Baker
Enzymatically-Responsive Delivery of Pro-Angiogenic Peptides for Therapeutic Vascularization .....................................................396A. H. Van Hove, D. S. W. Benoit
Intravenously-Administered Polymers for Modulating Clot Properties and Inducing Hemostasis .....................................................397L. W. Chan, X. Wang, H. Wei, L. D. Pozzo, N. J. White, S. H. Pun
Microencapsulated Insulin-Producing Cells Accelerate Diabetic Wound Closure.................................................................................398A. Aijaz, R. Faulknor, F. Berthiaume, R. Olabisi, A. Parekh
Chitosan Based Hydrogels for Delivering Oxygen and Sequestering Reactive Oxygen Species in Wound Healing ..........................399P. Patil, N. D. Leipzig, N. Fountas-Davis, P. Joshi, H. Huang, L. Shriver
A Synergistic Polydiolcitrate-Copper Metal-Organic Framework Nanocomposite Improves Wound Healing .................................400J. Xiao, G. Ameer
MSC-Laden Anti-inflammatory Hydrogel Improving Wound Healing of Diabetic Skin Ulcer ...........................................................401M. Xing, S. Chen, J. Shi, L. Zhang
Mitigation of Hypertrophic Scar Contraction and Stiffening Via an Elastomeric Biodegradable Scaffold ........................................402E. R. Lorden, K. J. Miller, L. Bashirov, M. Ibrahim, E. Hammett, Y. Jung, M. A. Medina, A. Rastegarpour, M. A. Selim, K. W. Leong, H. Levinson
TISSUE ENGINEERING 2 Hydrogel-Electrospun Mesh Composite for Prevention of Anastomosis Leakage .................................................................................403
A. Kishan, T. Touchet, C. Whitfield, N. Cohen, E. Cosgriff-Hernandez
A Biomaterial Strategy for Treatment of Ulcerative Colitis......................................................................................................................404T. J. Keane Jr., S. F. Badylak, S. Shaffiey, D. Hackam, D. Nagle
An Engineered Protein Hydrogel for Promoting Neurite Growth ...........................................................................................................405K. J. Lampe
3D Printed Bone Scaffolds with Biomimetic Nanomaterials and Vascular Mimicking Microchannels...............................................406B. Holmes, K. Bulusu, M. Plesniak, L. G. Zhang
Isolating the Effect of Stiffness on Valvular Interstitial Cells and its Role in Phenotype Control........................................................407K. E. Coombs, E. L. Hedberg-Dirk, M. N. Rush, A. Leonard
A Bio-inspired Hybrid Nanosack for Pancreatic Islet Transplantation in the Omentum .....................................................................408P. Tj Hwang, D. Lim, S. Gilbert, L. Tian, A. Shalev, H. Jun
Development of Surface Modified Polymeric Conduits for Nerve Regeneration....................................................................................409M. Uz, A. D. Sharma, D. S. Sakaguchi, S. K. Mallapragada
Engineering Tendons Using Adult Stem Cells Seeded in Mechanostimulated HUV ..............................................................................410B. Engebretson, S. Bonhoure, Z. Mussett, V. Sikavitsas
VASCULAR AND BLOOD CELLS RESPONSES TO NOVEL CARDIOVASCULAR BIOMATERIALS Surface Modified Poly(Vinyl Alcohol) Vascular Grafts Maintain Hemocompatibility..........................................................................411
M. T. Hinds, D. E. J. Anderson, M. F. A. Cutiongco, E. K. Yim
Microgel-based Materials for Augmentation of Hemostasis in Neonatal Cardiac Surgery Patients....................................................412A. C. Brown, S. Saxena, K. Ahlstedt, B. Ahn, W. Lam, N. Guzzetta, T. H. Barker, A. Lyon
Glypisomes: A Novel Construct for Enhancing Angiogenic Activity of Delivered Growth Factors.....................................................413A. J. Monteforte, B. Lam, S. Das, C. S. Wright, P. E. Martin, A. Dunn, A. B. Baker
Interaction of Endothelial Cells and Smooth Muscle Cells with ePTFE and Electrospun PTFE .........................................................414S. Lamichhane, T. Remund, M. Larson, P. Kelly, G. Mani
A Platelet-Inspired Nanomedicine Approach for Targeted Thrombolytic Therapy ..............................................................................415C. Kos, K. Ravichandran, W. Li, C. Modery-Pawlowski, A. Sen Gupta
Contributions of Prekallikrein and High Molecular Weight Kininogen to the Intrinsic Pathway of Coagulation ............................416Y. Yan, A. Moyer, L. Xu, C. A. Siedlecki
ACADEMIC-INDUSTRY COLLABORATIONS IN BIOMATERIALS RESEARCH Accelerated Thermoplastic Polyurethane Hydrolytic Stability Screening ..............................................................................................417
D. K. Dempsey, N. Aumsuwan, H. Swen, J. Zupancich, P. Gray, T. Touchet, E. Cosgriff-Hernandez, C. P. Chawla
Reversible Dose-Based Drug Release Mediated by Azobenzene/?-Cyclodextrin Complexation to Study Myofibroblast Activation...............................................................................................................................................................................418
E. M. Nehls, A. M. Rosales, K. S. Anseth
ADVANCED ANTIMICROBIAL MATERIALS Antimicrobial-tolerant Bacterial Biofilms Are Inhibited by Sharklet Microtopography ......................................................................419
E. E. Mann, M. C. Drinker, M. R. Mettetal, S. T. Reddy
Ultrasmall Gold Nanoparticles As Bactericidal Agents Against Planktonic and Biofilm Enveloped Staphylococci ..........................420S. K. Boda, U. Simon, B. Basu, W. Jahnen-Dechent
Multifunctional Peptides for Infections Free Implant Surfaces ................................................................................................................421D. Khvostenko, K. Boone, S. Vanoosten, D. Yucesoy, J. Ferracane, H. Davis, J. Mitchell, P. Arnold, C. Tamerler
ADVANCED ANTIMICROBIAL MATERIALS 2 Micro-Arc Oxidation Treatment for Improvement of Antibacterial Property of Titanium .................................................................422
Y. Tsutsumi, N. Niizeki, P. Chen, M. Ashida, H. Doi, K. Noda, T. Hanawa
Detachable Polymeric Films for Applications in Drug Delivery ...............................................................................................................423S. Gates, A. Shukla
PEO-Tethered Peptides for Capture of Circulating Bacteria and Endotoxin in Sepsis.........................................................................424K. F. Schilke, R. Raman
Synthesis of Zwitterionic Sol-Gel Films to Prevent Bacterial Adhesion ..................................................................................................425H. Qu, R. Moya, P. Ducheyne
Antimicrobial Nanotextured Dental Implant Surfaces Against Porphyromonas Gingivalis.................................................................426A. Au, S. Patel, W. Li, C. Wu, C. Sukotjo, T. Shokuhfar
ADVANCED HYDROGELS WITH HIERARCHAL STRUCTURES FOR BIOLOGICAL APPLICATIONS Hierarchical Macroporous Multifunctional Hydrogel Formation Via Thermally-induced Phase Separation for Neuronal Regeneration ..................................................................................................................................................................................427
S. Tang, B. Wing, E. Morin, S. Goddard, W. He
PEG/Poly(Acrylic Acid) Semi-IPN Hydrogels for Post-Synthesis Electrostatic Antibiotic Loading and Controlled Release .............................................................................................................................................................................................................428
Y. Wu, M. Libera
Chitosan-Containing Bioadhesive Hydrogels as Hemostatics ...................................................................................................................429Y. Koyama, S. Yamaguchi, Y. Kurachi, M. Eriguchi, T. Ito
Characterization of a Multi-Functional Tetronic Surgical Adhesive Containing Chitosan for Soft Tissue Applications.....................................................................................................................................................................................................430
L. Sanders, K. Webb, T. Mefford, J. Nagatomi
Robust Approaches to Interface External Tubing to Freestanding Microfluidic Hydrogels ................................................................431S. Faley, B. Baer, T. Larsen, L. M. Bellan
Photopatterning Hyaluronic Acid into Mechanically Robust Hydrogels Based on Melt-Assembled Networks of Sphere-Forming Block Copolymers .............................................................................................................................................................432
J. T. Lewis, T. S. Bailey
Thermoreversible Scaffolds Improve Transient Three-dimensional Culture by Facilitating Rapid Cell Recovery ..........................433J. M. Heffernan, D. J. Overstreet, S. Srinivasan, B. L. Vernon, R. W. Sirianni
Enzyme Resistance and Mechanical Stability of Genipin-Crosslinked Films .........................................................................................434A. Iftikhar, M. Cramer, C. Bettinger
High-Throughput Drop-Based Microfluidics To Prepare Stable Agarose Hydrogels ...........................................................................435E. Davé, C. Muus, D. A. Weitz
ADVANCES IN PROGRAMMABLE BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE PLGA-Porous Silicon Composite Microspheres: Optimization Insights of a Double Controlled Release Platform for Tissue Engineering Applications ............................................................................................................................................................436
L. Pandolfi, S. Minardi, F. Taraballi, L. Xaewu, E. Tasciotti
Gamma Irradiation-Controlled Burst Release Of Curcumin From Chitosan to Counteract Radiation Damage ..............................437R. Chauhan, M. J. Graves, B. Nunn, A. Akalkotkar, R. S. Keynton, P. A. Soucy, M. G. O'Toole
Elastin-like Polypeptide Microspheres: A Stimuli-Responsive Vehicle for Controlled Drug Delivery ................................................438Aniket, N. Tang, J. Rosenberg, A. Chilkoti, D. Needham
Examination of Radio-opacity Enhancing Additives in Shape Memory Polyurethane Foams .............................................................439A. C. Weems, J. E. Raymond, T. Gustavson, K. T. Wacker, B. Keller, K. L. Wooley, D. J. Maitland
pH Responsive Nanoparticles-in-Microparticles System for Oral Delivery of siRNA ...........................................................................440L. E. Strong, J. M. Knipe, N. A. Peppas
Self-Assembly of Heterochiral Peptides with Varied Sequence Patterns.................................................................................................441A. Koyfman, R. Appavu, S. Sheller, J. Rudra
Differential Rates of Oxanorbornadiene-Mediated Drug Tethering and Release from Thiolated Nanoparticles ..............................442A. Schudel, C. Higginson, M. Bellavia, M. Finn, S. N. Thomas
BASIC SCIENCE PROGRESS AND CLINICAL APPLICATIONS OF MULTI-FUNCTIONAL BIOMATERIALS: A FOCUS ON MULTI-DRUG BIOMATERIALS AND DEVICES Design, Fabrication and Functional Evaluation of Textile Packing Material for Tissue Debridement ...............................................443
Y. Fu, S. Tao, L. Wang, M. W. King
BENCHTOP MODELS TO SUPPORT MEDICAL DEVICE AND PHARMACEUTICAL INVENTION AND COMMERCIALIZATION Neck Impingement Testing of a Novel Hard on Hard Hip Bearing..........................................................................................................444
D. Rister, A. Parikh
Novel UKR Micromotion Assessment Method Utilizing Optical Measurement Techniques in Correlation with Finite Element Analysis .................................................................................................................................................................................445
R. Davignon, A. Gopalakrishnan, G. Yildirim
BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) Effects of 3D Modeling Parameters on Dimensional Accuracy of 3D-Printed Anatomical Structure .................................................446
K. Ogden, C. Aslan, G. Tillapaugh-Fay, D. D. Diallo, N. O. Ordway, P. Soman
Automatic Filter Layer-by-Layer Coating System for Construction of iPS-Derived 3D Tissues by Cell Accumulation Technique ...............................................................................................................................................................................447
D. Takagi, S. Kamono, Y. Amano, M. Matsusaki, S. Miyagawa, M. Akashi
BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) 2 Polymer-Based “Glue Scaffold” with Nanometer-Sized Extracellular Matrix Films for Tissue Engineering ....................................448
N. Uchida, S. Sivaraman, N. Amoroso, W. Wagner, A. Nishiguchi, M. Matsusaki, M. Akashi, J. Nagatomi
Engineering Alginate As Bioink for Bioprinting.........................................................................................................................................449Y. Mei, J. Jia, D. J. Richards, S. Pollard, Y. Tan, J. Rodriguez, R. P. Visconti, T. C. Trusk, M. J. Yost, H. Yao, R. R. Markwald
Highly Moldable 3D Nanofibrous Elastomeric Scaffolds with Enhanced Mechanical Properties........................................................450S. Lee, W. Choi, J. Jang
3D Printing of Bone-Templated Scaffolds ...................................................................................................................................................451S. J. Fernando, J. A. Sterling, S. A. Guelcher
Bioengineering an Artificial Ovary with 3D Printing ................................................................................................................................452A. L. Rutz, M. M. Laronda, K. A. Whelan, T. K. Woodruff, R. N. Shah
Perfusable 3D Microchannel Networks Made From Sacrificial Fibers Increase Cell Viability in Gelatin Scaffolds .........................453X. Wang, S. Faley, B. Baer, D. Bird, L. M. Bellan
Biofabrication of Tissue Constructs for Craniomaxillofacial Reconstruction ........................................................................................454C. Kengla, Y. J. Seol, H. Kang, J. J. Yoo, A. Atala, S. J. Lee
Fabrication of Multi-Material Tissue Scaffolds via Additive Manufacturing .........................................................................................455N. A. Chartrain, A. R. Schultz, M. Price, T. E. Long, C. B. Williams, A. R. Whittington
Using Electric Fields to Introduce Pores in Bacterial Cellulose Scaffolds for Tissue Engineering .......................................................456A. Rolong, P. Gatenholm, R. V. Davalos, A. Baah-Dwomoh
Exploring Methods for Controlling the Quality of Random and Aligned Electrospun Nanofibers .....................................................457C. F. Rediguieri, P. A. De Bank, G. L. B. Araujo, T. J. A. Pinto
Hybrid Scaffold-reinforced Extracellular Matrix Hydrogels for Cartilage Tissue Engineering ..........................................................458S. Sonnenberg, M. A. Taylor, L. Mellor, S. Mehendale, R. Shirwaiker, E. Loboa
Development of 3D Printed Hydrogel Scaffold with Core-shell Nanoparticles for Nerve Regeneration .............................................459S. Lee, W. Zhu, L. G. Zhang
BIO-INSPIRED CELLUAR MICROENVIRONMENTS In Vitro Tumor Intravasation Assays Using 3D-Human Blood- and Lymph-Capillary Models ..........................................................460
A. Nishiguchi, M. Matsusaki, M. Akashi
Induction of Intrafusal Muscle Fibers from Human Satellite Cells and Their Innervations by Human Stem Cell-derived Sensory Neurons ...............................................................................................................................................................................461
X. Guo, A. Colon, C. Martin, H. Vandenburgh, J. Hickman
The Correlation Between Substrate Stiffness and TGF-β1-Induced Hepatic Stellate Cell Activation.................................................462J. Narang, C. Lemmon, S. Marampudi
High Throughput Screening Format Identifies Synthetic Mimics of Matrigel for Tubulogenesis Screening .....................................463E. H. D. Nguyen, W. T. Daly, D. G. Belair, N. N. Le, W. L. Murphy
Material Properties and Differentiation Potential of Collagen-II Based 3D Microbeads for Cartilage Tissue Engineering .....................................................................................................................................................................................................464
R. Tiruvannamalai-Annamalai, D. Mertz, E. Daley, J. Stegemann
Effects of Preparation Condition of Tumor Cell-derived Matrices on Chemoresistance ......................................................................465T. Hoshiba, M. Tanaka
Dynamic Topographical Imprinting of Cellular Substrates......................................................................................................................466M. Ali, J. B. Shear
High Resolution Silica Tissue Replica As Cell Culture Scaffold for the Differentiation of Human Mescenchymal Stem Cells ........................................................................................................................................................................................................467
S. W. Tang, F. Lv, V. Leung, Y. W. Lam
Design of Facile and Tunable Hydrogels to Understand the Microenvironment’s Role in Breast Cancer Recurrence.....................468L. A. Sawicki, A. M. Kloxin
BIOLOGICALLY DERIVED MATERIALS FROM NATURAL SOURCES Aligned 3D Amino Acid Nanofiber Biomaterials........................................................................................................................................469
B. Li, X. Wang
Engineered Collagen-Mimetic Proteins for Wound Healing .....................................................................................................................470M. B. Browning, B. Russell, J. Rivera, M. Hook
Modular Gelatin Hydrogels Formed by Orthogonal Thiol-ene Photochemistry for 3D Hepatocyte Culture .....................................471T. Greene, C. Lin
Mechanical-stress Assisted Modulation of the Properties of Temperature-responsive Cell Culture Surface .....................................472Y. Akiyama, M. Matsuyama, N. Takeda, M. Yamato, T. Okano
Bioactive Modification of End-functionalized Multi-arm Poly(ethylene glycol) Affects Macroscopic Properties and Cellular Behavior............................................................................................................................................................................................473
J. Kim, S. M. Niedzielski, R. Singh, A. J. Putnam, A. Shikanov
Development of a Tissue Specific Acellular Extracellular Matrix for Intervertebral Disc Regeneration Using a Gentle Decellularization Process...................................................................................................................................................................474
R. A. Wachs, A. Hyyti, R. C. Cornelison, C. E. Schmidt
Acellular Collagen-Hydroxyapatite Scaffolds Support Osteoinduction After Subcutaneous Ectopic Implantation..........................475M. J. Meagher, H. E. Weiss-Bilka, D. R. Wagner, R. K. Roeder
In Vitro Cytocompatibility Study of Nanocellulose ....................................................................................................................................476L. Huang, Y. Lu, S. Ozcan, W. He
Optimization of Alginate Templated Polypyrrole Composites for Tissue Engineering Scaffolds.........................................................477C. J. Wright, B. Zhang, C. Yore, T. Pannell, T. W. Hanks
Characterization of Chitosan and the Effects of Cleaning ........................................................................................................................478J. D. Bumgardner, O. Jenkins, T. Martin, G. McGraw, W. O. Haggard
Decellualrized Cow-derived Diaphragm ECM Scaffold for Tissue Engineered Diaphragm ................................................................479H. Yi, Y. Zhang, L. Xue, B. Yang, G. Niu, Y. Zhang, A. Atala
Diffusion-Reaction Models of Genipin Incorporation into Fibrin Networks ..........................................................................................480M. Cramer, A. Iftikhar, C. Bettinger
Fabrication of Biodegradable β-TCP Scaffolds Using Natural Biogenic Magnesian Calcite Skeletons ...............................................481X. Zhang, L. Yang, L. Cao, W. Cui, Z. Guo, Y. Bai, R. Yang
Electrospun Chitosan Fibers for Insulin Delivery ......................................................................................................................................482M. G. Lancina III, L. Xu, N. D. Sheybani, H. Yang
BIOMATERIALS EDUCATION Modeling Biomaterial Research for Middle School Science Teachers .....................................................................................................483
C. Nelson, N. Bhattarai, S. Rahman, N. Rijal
Assessment Modality for Biomaterial Education Outreach to Improve Pedagogical Methods ............................................................484C. J. Gehrmann, G. S. McGraw, G. Schreyack, J. A. Jennings
Biomaterials Research Projects for Undergraduate Students: Exploring the Correlation between Silk Fibroin Protein Aggregation and Intrinsic Fluorescence.........................................................................................................................................485
S. Alibeik, P. Valverde, C. Bennett
BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Inter-species Variation in the Decellularization of Aortic Valves .............................................................................................................486
M. C. Vedepo, E. E. Buse, M. Armstrong, M. Detamore, G. L. Converse, R. A. Hopkins
Mechanical and Biological Evaluation of Small Diameter Blood Vessels with Weft-Knitted and Electrospun Bilayer Structure ............................................................................................................................................................................................487
M. W. King, Y. Xie, S. Kim, R. M. Hanel
Biomaterial Topography Promotes Endothelial Cell Migration via Disrupted VE-Cadherin Signaling.............................................488S. Mascharak, P. Benitez, S. Heilshorn
Stromal Cell-Derived Factor-1a Releasing Metallic Stent for Accelerated Re-endothelialization Mediated by Mobilization and Recruitment of Endothelial Progenitor Cells................................................................................................................489
S. N. Kang, Y. K. Joung, D. K. Han
In Vivo Assessment of Engineered Cardiac Patches for Repairs of Congenital Heart Defects .............................................................490J. G. Jacot, S. Pok, S. Igor, C. Tsao, A. Annapragada
Functional Materials: Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Primary Human Endothelial Cell Survival and Activation .....................................................................................................491
D. W. Howell, C. Duran, S. Tsai, S. E. Bondos, K. J. Bayless
Preparation and Physical Properties of a Small Diameter Decellularized Vascular Graft Covered with Electrospun Fibers ...............................................................................................................................................................................................................492
T. Kimura, H. Morita, P. Wu, N. Nakamura, K. Nam, T. Fujisato, A. Kishida
BIOMATERIALS FOR REGENERATIVE ENGINEERING Human Recombinant Chimeric Protein COMP-Ang1 Promotes Angiogenesis and Bone Regeneration in a Rat Mandible Bone Defect Model ........................................................................................................................................................................493
G. Bhattarai, S. B. Poudel, S. Kook, J. Lee
Engineered Polycaprolactone-magnesium Hybrid Porous Scaffold for Bone Regeneration .................................................................494K. W. K. Yeung, H. Wong, P. Chu, K. D. K. Luk, K. M. C. Cheung
Mechanical Improvement of Hyaluronic Acid (HA) Hydrogels and Incorporation of Polyethylene Glycol (PEG) ...........................495H. Lee, S. Jeong, J. Baek, J. Song, H. Kim
PCL Reinforcement of a Mineralized Collagen-GAG Scaffolds for In Vivo Implantation ...................................................................496D. W. Weisgerber, K. Erning, C. Flanagan, S. Hollister, B. A. Harley
Biodegradable Magnesium-Polymer Composite for Enhanced Corrosion Resistance and Mechanical Strength ..............................497D. Y. Shin, M. Kang, S. Kim, J. Song, H. Kim
Optimizing Mesenchymal Stem Cell Wound Healing Properties on Electrospun Silk with Selenium Nanoparticles........................498S. Chung, M. Stolzoff, P. Tran, B. Ercan, T. J. Webster
The Effect of Collagen Vitrigel Nanostructure on Stem Cell Derived Retinal Pigment Epithelial Maturation ..................................500X. Wang, J. Maruotti, J. Roman, H. Mao, D. J. Zack, J. H. Elisseeff
Microporous Biopolymer Cell Carriers Prepared by Microfluidic Device for Tissue Engineering .....................................................501J. Park, H. Lee, C. Han, H. Kim
Magnetite-doped Organic-inorganic Nanocomposite Scaffolds Stimulate Bone Cell Functions ..........................................................502J. Kim, K. Dashnyam, M. Kim, R. Perez, E. Lee, S. Seo, H. Kim
PEGylated Poly(Ester Amide) Elastomers with Tunable Physico-chemical, Mechanical and Degradation Properties ........................................................................................................................................................................................................503
Y. Xue, A. Patel, V. Sant, S. Sant
Feasibility of Novel Injectable Calcium Phosphate Cements Formulated with Bioactive Nanocomponent ........................................504S.-H. Shin, E.-F. Ahmed, R. Perez, D.-Y. Won, J.-H. Kim, S.-J. Seo, H.-W. Kim
Capturing Tissue Microenvironment on a Click-chemistry Based Biodegradable Polymer Membrane .............................................505C. Wang, J. Yang, W. P. Yau, Y. W. Lam, W. K. Yeung
Decellularized Lung Extracellular Matrix Electrospun with Poly-L-Lactic Acid for Tissue Engineering ..........................................506B. M. Young, R. A. Pouliot, B. A. Blakeney, B. P. Allen, G. E. Schreyak, R. L. Heise
Air-brushed Poly-DL-Lactic Acid Fiber Mats with Controllable Degradation for Tissue Engineering Applications .......................507W. Tutak, A. Behrens, J. E. Seppala, P. Kofinas, N. Hotaling
pH-Dependent Degradation of Poly(β-amino ester) Hydrogels ................................................................................................................508A. J. Chen, D. Puleo
BIOMATERIAL-TISSUE INTERACTION Modeling of Chronic Ventral Hernia in Rabbit ..........................................................................................................................................509
G. T. Hilas, M. S. Taylor, T. A. Pruitt, J. T. Corbett
PLLA Coated WE43 Magnesium with a Hydroxyapatite Interlayer for Enhanced Adhesion and Corrosion Resistance ........................................................................................................................................................................................................510
M. Kang, S. Kim, H. Kim, M. Diez
Clinical Biostability of Poly(Carbonate Urethane) Insulation in Neurostimulation Leads ...................................................................511G. Gallagher, C. Jenney
Medical Device Retrieval Programme : An Indian Initiative....................................................................................................................512J. Joseph, C. V. Muraleedharan, V. Ramanathan, A. Sabareeswaran, M. Mohanty
Bisphosphonate-Conjugated NIR Fluorophores for Bone-Specific Targeting and Imaging .................................................................513K. A. Nasr, S. L. Gibbs, H. S. Choi, K. Bao
Pore Formation Mediated by Polysaccharide Incorporation for 3D Skeletal Myotube Formation .....................................................514M. Rich, M. K. Lee, N. Marshall, J. Chen, Z. Mahmassani, M. Boppart, H. Kong
In Vivo Performance of Gellan Gum-based Structures: a Comparison Study Between Hydrogels and Spongy-like Scaffolds for Osteochondral Tissue Regeneration ......................................................................................................................................515
R. F. Canadas, D. R. Pereira, J. Silva-Correia, C. Viegas, A. Da Silva Morais, R. A. Sousa, A. P. Marques, R. L. Reis, J. M. Oliveira
Controlling Nano-Ferrofluid Permeability with Surface Engineering and Their Future Applications ...............................................516D. Shi, L. Sun, G. Mi, S. Bhattacharya, S. Nayar, T. Webster
Evaluation of Magnesium Alloys for Tracheal Stent Application ............................................................................................................517P. Saha, B. Lee, T. Yang, J. Waterman, T. Gilbert, P. Hebda, P. Kumta, J. Wu
Development of a Semi-Laparoscopic Cecal Abrasion Model for Peritoneal Adhesions in a Rat ........................................................518S. Mayes, S. Zawko, J. Ali, D. Peterson
Development of Tailored Bionanocomposites for Applications in Skin Tissue Regeneration ...............................................................519Y. S. Miranda Alarcón, A. M. Brown, I. A. Banerjee
Biocompatibility of the Intellirod System in an Ovine Posterior Lumbar Fusion Model ......................................................................520N. Russell, C. Christou, C. Tan, T. Wang, M. P. Pelletier, R. Eberle, W. R. Walsh
BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING Fluorenylmethyloxycarbonyl-based Peptide-Chitosan Hybrid Scaffolds for Potential Applications in Cartilage Tissue Regeneration .......................................................................................................................................................................................521
S. M. Romanelli, G. A. Knoll, I. A. Banerjee
ECM-mimic Coating of Biopolymer Scaffolds to Promote Bone Regeneration ......................................................................................522J.-E. Won, M.-H. Kim, H.-W. Kim
Biomimetic Collagen-Phosphorylcholine Hydrogels as Corneal Implants for High Risk Patients.......................................................523M. Islam, O. Buznyk, N. Pasyechnikova, M. Ljunggren, K. Meek, P. Lewis, S. Hayes, S. Iakymenko, J. Phopase, E. Alarcon, K. Merrett, W. Liu, P. Fagerholm, M. Griffith
Osteoblast Cellular Functions on Electron Beam Melting (EBM) Printed 3DTitanium Foam Structures as a Function of Porosity .......................................................................................................................................................................................524
K. Nune, D. Misra, L. Murr, S. Gaytan
Interpenetrating Collagen-Fibrin Hydrogels for Skeletal Muscle Regeneration ....................................................................................525S. Stagg, B. Pollot, C. R. Rathbone, A. Ong, T. Guda
BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING 2 Poly(ε-Caprolactone)/Gelatin Composite Electrospun Scaffolds with Porous Crater-like Structures for Tissue Engineering .....................................................................................................................................................................................................526
P. T. J. Hwang, R. Huiszoon, J. Ng, K. Murdock, G. Alexander, D. Lim, H. Jun
Characterizing Natural Hydrogel for Reconstruction of Three-dimensional Lymphoid Stromal Network to Model T-cell Interactions...........................................................................................................................................................................................527
J. Kim, B. Wu, S. Niedzielski, M. Hill, R. Coleman, A. Ono, A. Shikanov
Modulating MMP-2 Expression in HUVECs using PEG-conjugated Biomolecules ..............................................................................528J. A. Hammer, R. M. Schweller, J. L. West
In Situ Forming Gelatin-Poly(Ethylene Glycol)-Tyramine Hydrogels via Dual Enzyme of Horseradish Peroxidase and Gluose Oxidase ........................................................................................................................................................................................529
B. Y. Kim, J. W. Bae, K. D. Park
A Biomimetic Hydrogel Matrix Facilitates Evaluation of Cancer-associated Fibroblast Contributions to Tumor Angiogenesis ....................................................................................................................................................................................................530
S. Ali, J. L. West
Adhesive Peptide Sequences Regulate Valve Interstitial Cell Phenotypes and Collagen Deposition ...................................................531Y. Wu, K. J. Grande-Allen, J. L. West
Perfusable Biomimetic Scaffolds within Microfluidic Devices ..................................................................................................................532N. K. Virdone, N. A. Vera-Gonzalez, M. P. Cuchiara, J. L. West
Biomimetically Enhanced Demineralized Bone Matrices ..........................................................................................................................533S. Ravindran
Synthesis and Characterization of Chitosan Based Composite Scaffolds for Bone Tissue Engineering ..............................................534U. Adhikari, N. Bhattarai, N. Rijal, D. Pai
Optimizing Decellularization Detergents for Meniscus-derived Injectable Hydrogel............................................................................535J. Wu, Q. Ding, A. Dutta, Y. Hong
Hydrogels with Gradient Niche Cues Enhance Cartilage Regeneration with Zonal Organization ......................................................536F. Yang, D. Zhu
Optimization of Skeletal Myocyte Expansion for Potential Use in Cell Therapy for Stress Urinary Incontinence............................537Y. Hu, Y. Zhang, D. Zhang, H. Yi, Z. Wang, Y. Zhao, J. Yoo, A. Atala
Nano-hybrid Gel Scaffold for Biopharmaceuticals Delivery and Soft Tissue Engineering ...................................................................538H. Tan, M. Fan
BIO-NANOMATERIALS FOR CANCER THERANOSTIC TREATMENT Enhanced Radiation Therapy with Gold Nanoparticle-Loaded Multilayer Microdisks........................................................................539
A. D. Paro, P. Zhang, Y. Qiao, J. Xia, J. Guan, L. Ma, M. Su
Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells................................................................................................................................................................................540
R. J. Cavazos Jr., C. Morrison, J. Lampe, D. Nguyen, A. Harris, B. McFarlin, R. Petros
Biodegradable Thermal-Responsive Dual-Imaging Enabled Nanoparticles ...........................................................................................541Z. Xie, P. Jadeja, J. U. Menon, D. Thakore, N. Pandey, J. Yang, K. T. Nguyen
Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy .....................................................................................................................................................................542
J. Chen, Y. Bi, H. Gao, A. Lan, Y. Hu
BIOSENSING AND COMPLEX TISSUE REGENERATION Chemical Synthesis of Amine and Carboxyl Functionalized Polypyrrole Nanoparticles and Covalent Attachment of Antibody for Biosensing ............................................................................................................................................................................543
J. Mao, Z. Zhang
Functionalization of Gold Nanostars Sensors through Engineered Peptides for Bacterial Detection ..................................................544H. Yazici, T. J. Webster
A New Method for Molecular Detection and Identification in a Metallic Nanopore..............................................................................545S. Bearden, G. Zhang
Active Microrheology of Magnetically-aligned Fibrin Gel to Measure Stiffness Anisotropy................................................................546M. Keating, S. Riemenschneider, E. Botvinick, R. Tranquillo
Biocompatibility Evaluation of Skin-wearable Silver Nanowire Based Hydration Sensors ..................................................................547M. G. McCord, H. Ma, Y. Zhu
CARBON NANOMATERIALS 3D-Printed High-Content Graphene Composites for Tissue Engineering...............................................................................................548
R. N. Shah, A. E. Jakus, A. L. Rutz, S. W. Jordan
ATP-Responsive Hybrid DNA/Graphene Nanoassemblies for Anticancer Drug Delivery....................................................................549W. Sun, R. Mo, T. Jiang, Z. Gu
CARDIOVASCULAR BIOMATERIALS Cellular Responses of Smooth Muscle Cell to Zinc Ion..............................................................................................................................550
J. Ma, N. Zhao, D. Zhu
The Effects of Extracellular Magnesium Ion on Smooth Muscle Cells ....................................................................................................551J. Ma, N. Zhao, D. Zhu
Recapitulation of Myocardial Infarction Coupled with Patient-Specific iPSC-Derived Cardiomyocytes for Characterization of Chromosomal Mutation 9p21.....................................................................................................................................552
A. Kumar, K. P. Tenerelli, W. Ferguson, V. Lo Sardo, K. K. Baldwin, E. J. Topol, A. J. Engler
Biodegradable Polymer-Coated Drug-Eluting Stents with Improved Coating Stability Using Biodegradable Nano-Brushes.............................................................................................................................................................................................................553
T. M. I. Bedair, Y. Cho, Y. K. Joung, D. K. Han
Impacts of Manufacturing Processes and Temperature on the Water Absorption of a Siloxane-Based Polyurethane .....................554G. Gallagher, C. Jenney
Performance of OptimTM Insulation in an Accelerated In Vitro Model of Environmental Stress Cracking.......................................555A. Padsalgikar, G. Gallagher, E. Tkatchouk, C. Iacob, J. Runt
Image Modalities to Visualize Polyester Fabric in Endovascular Stent Grafts.......................................................................................556T. Yao, K. Mathews, I. Robertson, D. S. Lalush, L. W. Tse, G. Soulez, M. W. King
Characterization and Preparation of Bio-Tubular Scaffolds for Fabricating Artificial Vascular by Combining Electrospinning and 3D Printing System .....................................................................................................................................................557
S. J. Lee, D. N. Heo, Su A Park, I. K. Kwon
Suppression of Abdominal Aortic Aneurysms Using Targeted Nanoparticles That Deliver an MMP Inhibitor ...............................558A. N. Chowdhury, N. Nosoudi, N. Vyavahare
Heparin-mimicking Reverse Thermal Gel for the Treatment of Myocardial Ischemia.........................................................................559M. Laughter, B. P. Castellanos, D. J. Lee, A. L. Nelson, J. R. Bardill, D. Park
Microporous Textured Exterior Biointerface Prevents Stenosis in Arteriovenous Grafts ....................................................................561A. J. Marshall, A. Oda, B. Scanlan, M. G. Maginness
CELLS AND THEIR MICROENVIRONMENT: TRANSLATIONAL SCIENCES Pulsed Electrical Stimulation Activates Fibroblast Migration, Collagen Contraction, A-smooth Muscle Actin Expression and Smad 2/3 Phosphorylation .................................................................................................................................................562
M. Rouabhia, Z. Zhang, Y. Wang
Anisotropy Increases Myogenic Regulatory Factors and Regenerates Skeletal Muscle ........................................................................563M. J. McClure, D. J. Cohen, Y. C. Huang, M. Sunwoo, B. D. Boyan, B. D. Boyan, Z. Schwartz, Z. Schwartz
CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Effect of Crystal Lattice Modification of a-Cristobalite on Drug Adsorption and Release Kinetics ....................................................564
C. J. Trujillo, A. El-Ghannam
Development of Standardized Test Method for Evaluation of Nano-Crystalline Hydroxyapatite Forming Ability of Orthopedic, Dental and Craniofacial Device Materials .............................................................................................................................565
S. Brittain, P. Petrochenko, A. Kaiser, J. Johnson, L. Lo, J. Moreno, G. Kumar, A. Kaiser
Inkjet-printed Alumina Pattern for Improvement of the Activity of Periodontal Ligament Cells.......................................................566J. Kang, M. Lee, W. Seo, S. W. Lee, H. Choi
Effect of Coating and Pre-coating Techniques on the Compressive Strength of Fluorapatite Glass-ceramic Scaffolds...........................................................................................................................................................................................................567
O. Goudouri, J. Harless, I. Denry
Hydroxyapatite-PLGA-collagen Biomaterial for Bone Regeneration......................................................................................................568D. B. Bhuiyan, R. Tannenbaum, J. C. Middleton, T. Wick
MgO Nanoparticles Enhance Cell Functions and Reduce the Adhesion of Staphylococcus aureus on Hydroxyapatite-PLLA Nanocomposites for Orthopedic Tissue Engineering Applications ..................................................................569
D. J. Hickey, T. J. Webster
Fabrication and Characterization of Collagen/Apatite Scaffolds with Intrafibrillar Mineralized Collagen Fibers...........................570M. Wei, C. Hu
Cell Activity on the Alumina Microgroove Fabricated by Micro-molding Process................................................................................571J. Kang, S. Kim, M. Lee, W. Seo, S. W. Lee
CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Poly (Octanediol Citrate)/gallium-containing Bioglass Microcomposite Scaffolds.................................................................................572
E. Zeimaran, S. Pourshahrestani, I. Djordjevic, B. P. Murphy, N. A. Kadri, M. R. Towler
In-Vivo Performance of a Novel Bioabsorbable Suture Anchor in a Rabbit Femoral Model ...............................................................573O. Ortiz, K. Lahteenkorva
CHARACTERIZATION OF MICROENVIRONMENT OF IMMUNE CELLS IN WOUND HEALING M(IL-4) and M(IL-10) Induced Alterations in Gene and Protein Profiles of Rodent Wound Macrophages ......................................574
G. Bajpai, J. M. Durdik, J. Stenken
DELIVERY OF NUCLEIC ACIDS AND OTHER MOLECULES THAT MODULATE GENE EXPRESSION DNA Complex Release System by Injectable Auto-forming Alginate Gel Including Amorphous Calcium Phosphate .....................575
T. Ito, Y. Koyama
Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nano-Formulations...............................576T. A. Werfel, M. Miteva, C. Duvall
Surface Mediated Polymer Electrolyte and Nanostructured Calcium Phosphate Composite (NanoCaPs) Layers: Novel Approach to Non-Viral Gene Delivery ..............................................................................................................................................577
S. Shekhar, A. Roy, P. N. Kumta
Engineered RNA Nanorings for Efficient Delivery of siRNA....................................................................................................................578A. Koyfman, K. Afonin, A. Martins, E. Freed, W. Chiu, J. Rudra, B. Shapiro
The NanoAssemblrTM Platform - Microfluidic Manufacture of Nanomedicines for the Development of RNA Therapeutics....................................................................................................................................................................................................579
G. Heuck, C. L. Walsh, A. S. Ansari, A. White, K. Ou, A. Thomas, T. L. Leaver, E. C. Ramsay, P. R. Cullis, P. R. Cullis
One-pot Synthesis of Functional Poly(Amino Ester Sulfide)s and Utility in Delivering pDNA and siRNA ........................................580D. Siegwart, Y. Yan, L. Xue, J. Miller
DENTAL/CRANIOFACIAL Comparison of Electrospun and Lyophilized Gelatin + Chitin Whisker + Honey Membranes for Enhanced Periodontal Regeneration ..............................................................................................................................................................................581
A. E. Fetz, I. A. Rodriguez, B. W. Burger, G. L. Bowlin
Application of Stem Cells Derived from the Periodontal Ligament Or Gingival Tissue Sources for Tendon Tissue Regeneration ...................................................................................................................................................................................................582
S. Ansari, X. Xu, A. Moshaverinia, C. Chen, H. H. Zadeh, M. L. Snead, S. Shi
Composition Changes According to the Manufacturing Method of Dental Alloy Powder for Application of Selective Laser Melting System.....................................................................................................................................................................583
H. Lee, C. Lee, M. Kim, C. Lee, H. Kim
Observed of Change in the Hardness of Ni-Cr Alloy used to Dental Selective Laser Melting System .................................................584S. Choi, M. Hong, Y. K. Kim
Evaluation of the Effect of Early Bacterial Colonizers on the Surface of Retrieved Dental Healing Abutments ...............................585S. Sridhar, I. M. Gindri, P. Valderrama, T. G. Wilson Jr., D. C. Rodrigues
Cathepsin-K Targeting Nanotherapeutics for Regenerative Repair of Abdominal Aortic Aneurysms ...............................................586B. Jennewine, A. Ramamurthi
Preparation of Decellularized Mandible Bone with Periodontal Membrane for Periodontal Reconstruction ...................................587N. Nakamura, A. Ito, K. Nam, T. Kimura, T. Fujisato, T. Tsuji, A. Kishida
Correlation Between Rheological Behavior and Adhesion Properties of Denture Adhesives ...............................................................588N. Roohpour, S. Ghaderi
DRUG DELIVERY Nanogels of Hydrophobized Methylcellulose ..............................................................................................................................................589
M. Jamard, T. R. Hoare, H. Sheardown
Characterization of Crosslinked Gelatin Microspheres for Controlled Growth Factor Delivery ........................................................590P. A. Turner, J. P. Stegemann
Halloysite Nanotubes with Polyelectrolyte Nano-coatings Embedded with Rifampicin ........................................................................591W. R. Grimes Jr., D. K. Mills
Combinatorial Therapy of Rolipram and pNGF for Traumatic Brain Injury .......................................................................................592C. Macks, S.-J. Gwak, G. Temples, G. Korneva, J. Lee
Ricinoleic acid Encapsulation into Liposomal Matrix for Cutaneous Application.................................................................................593A. A. A. Nada, R. A. Abd El Azeem
DRUG DELIVERY 2 Incorporation of Protein-based Therapeutic Agents into Coaxial Electrosprayed Particles for Cardiac Regeneration ...................................................................................................................................................................................................594
M. Zamani, M. P. Prabhakaran, E. S. Thian, S. Ramakrishna
Combination of Cold Atmospheric Plasma and Nanoparticles Drug Delivery toward More Efficient Breast Cancer Therapy............................................................................................................................................................................................................595
W. Zhu, S. Lee, M. Keidar, L. G. Zhang
Controlled Release of Ophthalmic Therapeutics from Injectable, Resorbable Copolymer Scaffolds..................................................596G. Prosperi-Porta, B. Muirhead, H. Sheardown
Cell Membrane-mimetic Polymeric Micelles as Carriers for Drug Delivery ..........................................................................................597G. Liu, Y. Wang
Smart Hyperthermia Nanofiber Meshes With ‘On-Off’ Drug Release For Cancer Therapy ...............................................................598M. Ebara, E. Niiyama, K. Uto, C. M. Lee, T. Aoyagi
Hydroxyapatite-Calcium Sulfate Biphasic Microspheres As a Growth Factor Carrier for Sustainable Release ...............................599J. Baek, J. Song, H. Kim
Resorbable Bioactive Antimicrobial Implant for Bone Regeneration......................................................................................................600A. El-Ghannam, K. A. Aly Ahmed
PLGA/Chitosan based Composite Microspheres for Drug Delivery ........................................................................................................601S. Rahman, N. Bhattarai
An Accelerated Release Study to Evaluate Long-acting Levonorgestrel Contraception Dosage Forms..............................................602L. Wang, T. Lowe, S. Ananthula
The Effect of Induced Cell Alignment on the Endocytosis of Nanoparticles ...........................................................................................603P. Fattahi, P. J. Butler, J. L. Brown
Characterization of Pentagalloyl Glucose (PGG) loaded BSA Nanoparticles as Targeted Therapy for Abdominal Aortic Aneurysm (AAA) Regression ............................................................................................................................................................604
N. Nosoudi, A. Chowdhury, N. Vyavahare
Synthesis and Characteristics of PEI-based Copolymers and Nanoparticles for Potential Gene Delivery Applications.....................................................................................................................................................................................................605
C. Liu, M. Wang
DRUG DELIVERY FOR IMMUNOMODULATION Negatively Charged MRI Nanoprobes for Dendritic Cell Labeling and in Vivo Tracking ...................................................................606
H. Ai, C. Wu, L. Yang, Y. Xu, J. Wu, W. Zhu, C. Xia, Q. Gong, B. Song
Delivery of Indoleamine 2,3 Dioxygenase for the Induction of Immune Tolerance................................................................................607E. Bracho-Sanchez, A. Hassanzadeh, B. G. Keselowsky
In Vivo Macrophage Activation via Locally Delivered Dexamethasone ..................................................................................................608G. Keeler, J. Durdik, J. Stenken
Macrophage Response to Chitosan/poly-(γ-Glutamic Acid) Nanoparticles Carrying an Anti-inflammatory Drug...........................609R. M. Gonçalves, A. C. L. Pereira, I. O. Pereira, M. J. Oliveira, M. A. Barbosa
Less Phagocytosis of Biotinylated Polymeric Prodrug Micelles Using CD47-Streptavidin Fusion Protein.........................................610A. Sawdon, C. Peng
Tobramycin and Vancomycin Release from Local Delivery Devices .......................................................................................................611C. M. Wells, J. A. Jennings, W. O. Haggard, H. S. Courtney
ENGINEERING CELLS & THEIR MICROENVIRONMENTS Dynamically Stiffening Hydrogels Differentially Modulates Malignant Transformation of Mammary Epithelial Cells ..................................................................................................................................................................................................................612
S. Wei, J. Yang, A. Engler, M. Ondeck
Characterizing Effects of Microenvironments on Mechanical Properties of Cardiac Microtissues.....................................................613A. Desai, D. Dean
Heparin Cell Coating Effects on Cell Number During Mesenchymal Stem Cell Aggregate Culture with FGF-2..............................614J. Lei, E. Trevino, J. S. Temenoff
ENGINEERING TISSUE INTERFACES The Evaluation of Gold and Hydroxyapatite Nano-grafts in a Green Fluorescent Protein Porcine Model ........................................615
S. E. Smith, R. White, D. Grant, S. Grant
In Vitro Evaluation of Osteogenic Activity of Human Adipocyte Derived Stem Cells on Varied Scaffold Formulations ...................................................................................................................................................................................................616
A. V. Janorkar, P. Bierdeman, B. Gurumurthy
Tissue Regeneration of Tendon-Bone Junction: Evaluation of the Role of TgfbR2 Expressing Progenitor Cells on Multiphase Resorbable Braided Scaffolds...................................................................................................................................................617
H. Ramakrishna, T. He, T. Li, J. Temple, A. Spagnoli, M. King
Reconfigurable Substrate Topography for Tracking Cell Dynamics .......................................................................................................618P. Pholpabu, C. Bettinger, A. Balasubramanian, S. Kustra, H. Wu
HANDS-ON BIOMATERIALS RESEARCH Residual Volatiles Quantification for Novel Matrices ................................................................................................................................619
C. Culbreath, S. McCullen, C. Fitzwater, J. Corbett
Compositional Changes In Vitro for Two Glycolide Based Copolymers .................................................................................................620D. R. Ingram, J. T. Corbett, M. S. Taylor, S. D. McCullen
Building Scientific Confidence in BME Undergraduates via Inquiry-guided Biomaterials Laboratory .............................................621S. E. Stabenfeldt, C. Ankeny
Development of a 3-week Intensive Interdisciplinary Biomaterials Course for Non-engineering Majors...........................................622C. J. Wright, V. L. Turgeon
HARNESSING BIOMATERIALS TO ENGINEER THE ADAPTIVE RESPONSE FOR IMMUNITY OR TOLERANCE Immobilizing CD47 Polypeptide on Implantable Biomaterials.................................................................................................................623
C. M. Evaro, B. E. Mitchell, Z. Gu, M. W. King
HIGH-THROUGHPUT METHODS TO CONTROL CELL BEHAVIOR Microwell Arrays for High-throughput Investigation of Multi-species Biofilm Formation ..................................................................624
R. Hansen, C. Timm, S. Retterer
Engineering Hydrogels with Dual Gradients of Mechanical and Biochemical Cues to Decipher Stem Cell-Niche Interactions......................................................................................................................................................................................................625
X. Tong, J. Jiang, D. Zhu, F. Yang
Electrospun Photoclickble Thio-ene Poly(ethylene glycol) Hydrogel Microarrays for Stem Cell Fate Optimization........................626S. Sharma, M. Floren, W. Tan, S. Bryant
INJECTABLE BIOMATERIALS FOR TISSUE REGENERATION Composite Hydrogel Scaffold for Increased Fat Retention after Surgical Graft Procedure.................................................................627
C. M. Mahoney, D. Minteer, K. G. Marra, P. Rubin
Injectable Hydrogel based on Supramolecular Inclusion Complexes between Alginate-graft-Cyclodextrin and Polypropylene Glycol .....................................................................................................................................................................................628
T. Miao, S. L. Fenn, P. N. Charron, R. A. Oldinski
Degradation and Cell Survival in a Fast-Degrading Thio-Acrylate based Hydrogel .............................................................................629A. Emmakah, C. Lin, T-M. G. Chu
Injectable Enzymatically Crosslinked Hydrogels: A Unique Platform with Tunable Degradation Properties ..................................630S. V. Gohil, A. Padmanabhan, L. Nair
Development of a Novel Injectable Alginate-collagen-apatite Hydrogel for Bone Tissue Regeneration..............................................631S. Bendtsen, M. Wei
A Hydrogel for Local T Lymphocyte Delivery Towards Enhanced Cancer Immunotherapies............................................................632C. Ceccaldi, A. Monette, E. Assaad, R. Lapointe, S. Lerouge
Shear Strength of Thermogelling Scaffold for Intervertebral Disc (IVD) Tissue Engineering .............................................................633T. Mauriello, T. Christiani, P. Myers, D. Collins, A. Nitzl, E. England, C. Iftode, J. Kadlowec, A. J. Vernengo
Mechanically Enhanced Hyaluronic Acid-Based Hydrogels via Dual-Crosslinking Process ................................................................634J. Song, H. Kim, S. Jeong
Preparation of Poly(Ethylene Glycol)-B-Polyester Block Copolymers with Zwitterionic End Group for Thermo-Responsive Properties. ...................................................................................................................................................................................635
J. H. Park, D. Y. Kwon, B. K. Lee, C. H. Kim, M. S. Kim
In Vitro and in Vivo Evaluation of Chitosan-sotradecol Hydrogel, An Embolizing Sclerosing Agent for the Treatment of Endoleaks.................................................................................................................................................................................636
F. Zehtabi, A. Fatimi, A. Bertrand-Grenier, G. Soulez, S. Lerouge
Electrospinning of Alginate Micro-Beads ....................................................................................................................................................637N. Bhattarai, N. Rijal, R. Blount
Injectable Thermosensitive Chitosan Hydrogels with Enhanced Properties ..........................................................................................638E. Assaad, M. Maire, S. Lerouge
Extracellular Matrix Hydrogels from Decellularized Lung Tissue ..........................................................................................................639R. A. Pouliot, N. S. Mikhaiel, B. Wong, R. L. Heise
INNATE IMMUNITY AND INFLAMMATION IN BIOMATERIALS CONTEXTS Macrophage Polarization in Response to Self-Assembling Peptides ........................................................................................................640
R. De Loera, Y. Vigneswaran, J. Collier
Material-Modulated Polymorphonuclear Leukocyte Degranulation Affects Monocyte Adhesion on Endothelial Cells Under Shear Stress ...............................................................................................................................................................................641
T. J. Lieberthal, H. C. Cohen, J. Kao
In Vivo Effect of Locally-Delivered Modulators on Cytokine Production and Macrophage Activation .............................................642K. Alkhatib, G. D. Keeler, T. M. Poseno, J. M. Durdik, J. A. Stenken
Effects of Age-Related Changes in ECM Upon Macrophage Polarization ..............................................................................................643S. T. Lopresti, S. Patil, S. Dash, S. Bowers, L. Zhang, C. L. Dearth, B. N. Brown
LOCAL DELIVERY OF DRUGS AND GROWTH FACTORS FROM IMPLANT COATINGS Control of PLL/HA Multilayer Film Formation Via Crosslinkable Hyaluronic Acid Derivatives: The Differences Between Fast (Tyramine) and Slow (Aldehyde) Crosslinking Moieties ...................................................................................................644
H. Knopf-Marques, L. Wolfowa, S. Singh, V. Velebny, P. Schaaf, A. Ghaemmaghami, N. E. Vrana, P. Lavalle
Surface Modification of CoCr Alloy Using Vitamin-E for Cardiovascular Stents .................................................................................645E. Thiruppathi, J. Anderson, M. Larson, G. Mani
Model for Drug Partitioning in DAEMA Containing Poly(HEMA)-based Hydrogels using Coomassie Brilliant Blue ....................646R. Idziak, C. Kotanen, R. Sullivan, A. M. Wilson, D. R. Janagam, T. L. Lowe, A. Guiseppi-Elie
Biodegradable Antibiotic-releasing Implant Coatings to Prevent Orthopaedic Implant Infections ....................................................647A. A. Ashbaugh, J. Shahbazian, L. Miller, H. Mao, X. Jiang
In Situ Regeneration of Bioactive Coatings Using Evolved Staphylococcus Aureus Sortase A ............................................................648H. O. Ham, Z. Qu, E. Chaikof
MACROMOLECULAR DRUG DELIVERY Multifunctional SPIO Labeled Calcium Phosphate Microparticles for Localized Therapeutic Protein Delivery..............................649
A. E. B. Clements, C. S. Chamberlain, E. Aktas, R. Vanderby Jr., W. L. Murphy
Polymersomes: Towards Treatment of Neurodegenerative Disorders through Enzyme Replacement Therapy ...............................650J. Larsen, E. Pearce, D. Martin, M. Byrne
MATERIALS AND MATRICES FOR OSTEOCHONDRAL TISSUE ENGINEERING Cell-laden Nanofibrous Membrane Design for Osteochondral Repair ....................................................................................................651
J. Park, M. Kim, G. Jin, H. Kim
Analysis of Alkaline Phosphatase Expression and Tissue Mineralization in a Woven Tissue Engineering Test System ..............................................................................................................................................................................................................652
J. Gilmore, F. Yin, K. J. L. Burg
Fabrication of a TGF-β3 Encapsulated PLCL Scaffold by Supercritical CO2-HFIP Co-Solvent System ...........................................653S. H. Kim, S. H. Kim, Y. Jung
Collagen-Alginate-Hyaluronan Composite Hydrogels for Effective Culture and Maintenance of Chondrocytes..............................654H.-W. Kim, J. G. Zhen, C. Mahapatra
MECHANICAL CHARACTERIZATION OF BIOMATERIALS Finite Element Analysis of a Single Barbed Suture Using Beam Theory.................................................................................................655
M. Jeffries, J. S. Strenkowski, J. Cole, G. L. Ruff, M. W. King, H. Cong
Molecular Modulation of Long Lasting Absorbable Polymers for Compliance and Selective Degradation .......................................656J. A. Lilley, K. D. Gray, M. S. Taylor
The Stress-Relaxation Behaviors of Collagen-Depleted Heart Valve Tissues .........................................................................................657S. Huang, H.-Y. S. Huang
Biomechanical and Biochemical Study of Muscle-Tendon Junctions and Tendon-Bone Insertions ....................................................660B. Danley, X. Wu, M. Pankow, K. Peters, H.-Y. S. Huang
In Vivo Evaluation of Cervical Stiffness Evolution During Induced Ripening Using Shear Waves Elastography: Insight from an Animal Model......................................................................................................................................................................662
L. Peralta Pereira, E. Mourier, C. Richard, M. Tanter, G. Rus, P. Chavatte-Palmer, M. Muller
Multiple Length-Scale Spherical Indentation of PEG and Alginate-Based Hydrogels ..........................................................................663J. M. Shapiro, B. G. Bush, F. W. Delrio, R. F. Cook, C. A. Stratakis, M. L. Oyen
Tg and Fragility Determination of Glass-Forming Sugars using a Dynamic Mechanical Analyzer ....................................................664L. Weng, G. D. Elliott
MODULATING THE NEURAL MICROENVIRONMENT In Vitro Study of Astrocyte and Macrophage Response to Silicon Surface Modified with Cationic Microgels .................................665
E. Morin, S. Tang, K. Rogers, W. He
Magnesium Ferrite for Neural Applications ...............................................................................................................................................666Z. S. Thompson, N. Bhattarai
The Chronic FBR and Recording Performance in Aged Rat Cortex using High Density Silicon Recording Arrays ........................667M. B. Christensen, N. F. Nolta, P. A. Tresco
Markers of BBB Leakiness Correlate with Single Unit Recording Performance in High Density Penetrating Electrode Arrays Implanted Chronically in Rat Motor Cortex................................................................................................................668
N. F. Nolta, M. B. Christensen, P. A. Tresco
Controlling the Local Environment to Improve Schwann Cell Response ...............................................................................................669J. Stukel, W. Zhou, R. Willits
Transcranial Direct Current Stimulation (tDCS) Enhances Recovery From Motor Deficits Following Neonatal HIE Stroke.......................................................................................................................................................................................................670
C. L. Anderson, T. Demarse, M. Weiss, M. Douglas-Escobar, P. Carney, C. Rossignol
MOLECULAR MECHANISMS GOVERNING PROTEIN-SURFACE AND CELL-SURFACE INTERACTIONS The Role of Molecular Interaction Forces in Protein Adsorption Process on Materials Surfaces .......................................................671
S. Sakata, Y. Inoue, K. Ishihara
Crosstalk Between Integrin-β1 and BMPR1A Mediate Matrix Regulated MSC Osteogenesis ............................................................672R. Guo, S. Lu, J. M. Page, J. A. Sterling, S. A. Guelcher
The Effect of Network Properties on the Antifouling Properties of Amphiphilic Crosslinked Networks ...........................................673L. Villada, C. Kizilkaya, A. B. Brennan
MULTIFUNCTIONAL NANOMATERIALS FOR ENGINEERING COMPLEX TISSUES AND DRUG DELIVERY Targeted Drug Delivery Via Magnetic Nanoparticles: Novel Treatment for Canine Osteosarcoma ...................................................674
A. Kovach, T. Szasz, Z. Nelson, M. Cavalcanti, J. Gambino, L. Williams, J. Liao, R. Prabhu
High Surface Area Patterned Hydrogels for Drug Delivery or Tissue Engineering Applications ........................................................675M. Caldorera-Moore, L. Villermin
Polymeric Micelle as a Nucleic Acid Carrier for Axonal Regeneration in CNS .....................................................................................676S. Gwak, B. Green, C. Macks, K. Webb, J. S. Lee
Polymeric Micelle as a Drug and Gene Delivery Carrier for Brain Tumor ............................................................................................677B. Green, S. Gwak, G. Temples, J. S. Lee
Tumor-Targeting Upconversion–Nanoparticle-Based Unimolecular Micelles for Simultaneous Chemotherapy, Photodynamic Therapy, and Fluorescence Imaging ..................................................................................................................................678
G. Chen, L. Wang, S. Gong
MULTISCALE BIOMATERIAL DESIGN Encapsulating Hydrogels with Multi-Scale Porosity for Islet Transplantation to Treat Type 1 Diabetes...........................................679
P. Rios, X. Zhang, X. Luo, L. Shea
Effects of Processing on Glycoprene® 6829 Glycolide/Caprolactone/Trimethylene Carbonate Polyaxial Random Copolymer: A Preliminary Report ...............................................................................................................................................................680
C. Diruscio, G. Hilas, S. McCullen, M. S. Taylor
Mechanical Properties of Polypropylene-ePTFE Surgical Mesh Explanted After In Vivo Function...................................................681E. Casey, C. Hefner, K. Williams, A. Phillips, B. Heniford, A. Lincourt, M. Harman
Mechanically Tunable Hyaluronan-Based Hydrogels for Dental Pulp Stem Cell Growth....................................................................682S. Ananthula, K. B. Compton, D. R. Janagam, T. L. Lowe
MULTI-SCALE MATERIALS DESIGN FOR ABIOTIC-BIOTIC INTERFACES Anisotropic Supported Lipid Bilayers for Spatially Dynamic Surface Protein Presentation................................................................683
R. A. Meyer, M. P. Mathew, J. C. Sunshine, R. B. Shmueli, Q. Ren, K. J. Yarema, J. J. Green
NANOBIOMATERIAL AND DRUG DELIVERY STRATEGIES FOR DENTAL/CRANIOMAXILLOFACIAL REPAIR/REGENERATION Biosynthetic Materials Facilitate Effective Neurosurgical Closure ..........................................................................................................684
M. Macewan, T. Kovacs, W. Ray, M. Talcott
Random Acrylate Copolymer Surface Grafting to Poly(dimethyl siloxane) Elastomer Surfaces for Improved Anti-Biofouling ........................................................................................................................................................................................................685
C. Kuliasha, L. Villada, J. Royal, J. Finlay, M. Callow, J. Callow, A. Clare, A. Brennan, J. Chen
Evaluation of a Ciprofloxacin and Metronidazole Encapsulated Biomimetic Nanomatrix Gel on Enterococcus Faecalis and Treponema Denticola...............................................................................................................................................................686
S. Kaushik, T. Walker, J. Park, J. Scoffield, A. Andukuri, G. Alexander, B. Brott, P. Eleazer, H. Wu, N. Childers, H. Jun, K. Cheon
Controlled Release of Simvastatin from Anodized Ti Granules for Improving Its Antibacterial Effects ...........................................687Z. Gorgin Karaji, B. Houshmand, M. Jamadi Khiabani, S. S. Shafiei
Antimicrobial Effect of Calcium Phosphate Spheres Decorated with Ag nanodots on Periodontal Pathogens ..................................688T. B. Martin, D. A. V. Pulgarin, J. P. Babu, M. Shahbuddin, J. A. Jennings, J. D. Bumgardner, S. R. Mishra
NANOMATERIALS Surfactant Functionalization Induces Robust, Differential Adhesion of Tumor Cells and Blood Cells to Charged Nanotube-Coated Biomaterials Under Flow ...............................................................................................................................................689
M. J. Mitchell, C. Castellanos, M. King
Effect of Red Selenium Nanoparticles on Head and Neck Squamous Cell Carcinoma ..........................................................................690C. E. Hassan, T. Webster
Synthesis of Core/Shell Nanorod of Bismuth Doped Hydroxyapatite with Improved Antimicrobial Characteristics: a Facile Approach...........................................................................................................................................................................................692
M Selvakumar, S. K. Jaganathan, S. Chattopadhyay, G. B. Nando
Control of Clustered Iron Oxide Interparticle Spacing and Their Magnetic Properties.......................................................................693D. Wang, B. Lin, H. Ai
Synthesis and Characterization of CREKA-conjugated Iron Oxide Nanoparticles for Hyperthermia Applications ........................694A. K. Hauser, K. W. Anderson, Z. Hilt
Functional Clay Nanotube-Enzyme Biocomposites ....................................................................................................................................695J. Tully, R. Yendluri, Y. Lvov
Long Term Delivery of Nerve Growth Factor by Nano/microparticles for Enhancing Peripheral Nerve Regeneration ...................................................................................................................................................................................................696
A. D. Sharma, M. Uz, D. S. Sakaguchi, S. K. Mallapragada
Target-Specific Stimuli-Responsive Protoporphyrin IX Polysilsesquioxane Nanoparticles to Improve Photodynamic Therapy for Cancer Treatment...........................................................................................................................................697
J. L. Vivero-Escoto, Z. Lyles, D. L. Vega
Functionalized Polymersomes for Trapping the Ebola Virus ...................................................................................................................698C. Li, B. M. Geilich, T. J. Webster
Multifunctional Mesoporous Silica Nanoparticles for the Delivery of Cisplatin and Gemcitabine to Treat Cancer .........................699E. Fink, A. Hashemi, J. Pan, M. Alvarez-Berrios, J. Vivero-Escoto
Reducing Bacterial Adhesion on Surface Modified Titanium...................................................................................................................700H. Yazici, T. J. Webster, G. Bhardwaj
Shape and Surface Effects on the Cytotoxicity of Gold Nanospheres and Gold Nanostars...................................................................701P. M. Favi, M. Gao, L. J. S. Arango, S. P. O. Alvarez, M. M. Valencia, T. J. Webster
EDTA Loaded BSA Nanoparticles for Targeted Therapy to Reverse Vascular Calcification in Chronic Kidney Disease Animal Model ....................................................................................................................................................................................702
S. R. Karamched, N. Nosoudi, N. Vyavahare
Gellan-Gum Coated Gold Nanorods as Intracellular Drug Release System for Regenerative Medicine ............................................703S. Vial, S. Vieira, M. Carvalho, R. L. Reis, P. L. Granja, J. M. Oliveira
NANOTHERAPEUTICS FOR CARDIOVASCULAR APPLICATIONS Keratose as a Novel Drug Carrier for Drug Coated Balloons...................................................................................................................704
E. Turner, S. Tomblyn, L. Burnett, S. K. Yazdani
Multi-Functional Nanoparticle Development for Glycocalyx Heparan Sulfate Regeneration on Cultured Endothelial Cells .............................................................................................................................................................................................705
M. Cheng, H. Homayoni, R. Kumar, S. Sridhar, T. Webster, E. Ebong
Multifunctional Magnetic Nanoparticles to Restore Elastic Matrix Homeostasis in Abdominal Aortic Aneurysms .........................706B. Sivaraman, G. Swaminathan, L. Moore, M. Zborowski, A. Ramamurthi
NEXT GENERATION BIOMATERIAL AND DRUG DELIVERY TECHNOLOGIES FOR WOUND HEALING Microfluidic-based Generation of Protease-degradable PEG-MAL Microgels for Protein Delivery...................................................707
C. Gonzalez Garcia, D. Headen, M. Salmeron-Sanchez, A. J. Garcia
Nitric Oxide-Releasing Electrospun Polyurethane Wound Dressings......................................................................................................708B. V. Worley, R. J. Soto, M. H. Schoenfisch
Tunable Polyester Matrices Based On Sebacic Acid Using Crosslinking As A Strategy In Combinatorial Approach......................709Y. Chandorkar, G. Madras, B. Basu
High Moisture Vapor Transmission Rate and High Fluid Absorption Films for Wound Dressings....................................................710L. Miinea, P. Basone, A. Camardo, J. Baxter, E. Rohr, N. Marchant
Growth Factor Release from Poly(Ethylene Glycol) Diacrylate Hydrogels As a Treatment for Chronic Wound Healing .............................................................................................................................................................................................................711
P. Krzyszczyk, R. Olabisi
Effect of Polymer Architecture on Physical and Mechanical Properties of High Glycolide Content Polymers..................................712S. McCullen, C. Culbreath, J. E. Dixon, J. Corbett, M. S. Tayor
Biofunctionalized Hydrogels for Intestinal Epithelial Stem Cell Delivery...............................................................................................713R. Cruz-Acuna, A. E. Farkas, A. Nusrat, A. J. García
Bioresorbable Ureteral Stent Translation for in Vivo Model....................................................................................................................714A. A. A. Barros, C. Oliveira, E. Lima, R. A. C. Duarte, R. L. Reis
Delivery of Doxycycline from PLGA-Coated Hernia Meshes ...................................................................................................................715T. A. Q. Phan, D. A. Puleo, S. K. Ramineni, M. E. Brown, P. D. Fisher
Self-Assembling MMP-2 Cleavable Hydrogel Drug Delivery Systems; Neural Tissue Biocompatibility and Response ..........................................................................................................................................................................................................716
K. M. C. Koss, M. Churchward, K. Todd, L. D. Unsworth
Fabrication and Characterization of Hybrid Polymeric Scaffolds ...........................................................................................................717A. H. Najarzadeh, D. A. Puleo
Heparin-eluting Vascular Suture for Preventing Thrombosis and Stenosis ...........................................................................................719M. Dibalsi, S. Bae, J. S. Lee, G. Korneva, K. Kornev
Highly Elastic Nanofibrous Scaffolds for Skin Tissue Engineering Applications ...................................................................................720M. Mohiti-Asli, C. Molina, K. Rietzler, B. Pourdeyhimi, E. G. Loboa
In Vitro and In Vivo Degradation and Biocompatibility Evaluation of Chitosan Sponges and Paste..................................................721C. S. Rhodes, M. Whitaker, A. C. Parker, H. Doty, J. A. Jennings, W. O. Haggard
Arabinoxylan Sponges for Wound Healing Applications ..........................................................................................................................722D. C. Aduba Jr., A. Yeudall, H. Yang
OPHTHALMIC BIOMATERIALS Purification of an Acrylic IOL Dye Additive by a Solvent Washing Process – Effect of Precipitation Temperature ........................723
D. Urbaniak, M. D. Lowery, C. B. Hu
A Suspension of Porcine Cartilage Extra-cellular Matrix Exerts Anti-Angiogenic Effect in a Rabbit Corneal Model .....................724H.-W. Yun, S. Y. Kim, B. R. Song, T.-I. Kim, B. H. Choi, Y. J. Kim, S. R. Park, S.-H. Park, B.-H. Min
ORTHOPAEDIC BIOMATERIALS 2 Collagen Self-assembly on Orthopedic Magnesium Biomaterials Surface and Subsequent Bone Cell Attachment ..........................725
N. Zhao, J. Ma, D. Zhu
Effect of Poisson’s Ratio on the Intrinsic Mechanical Properties of Poly (Vinyl Alcohol) Hydrogels: Preliminary Results ..............................................................................................................................................................................................................726
M. A. Vaughn, K. J. L. Burg, J. T. Corbett
Structural Analysis of Gallium Based Glass Polyalkenoate Cements by Infrared Spectroscopy .........................................................727A. M. F. Alhalawani, D. Curran, M. Towler
Osteogenic and Antimicrobial Properties of Chitosan Treated Titanium Surface in a Co-Culture System of Peri-Operative Infection Model: An in Vitro Study ...........................................................................................................................................728
N. Ghimire, Y. Sun, Y. Deng
Microwave Processing of Amorphous Magnesium-Calcium Phosphate..................................................................................................729E. Babaie, Y. Ren, S. B. Bhaduri
Modularly Assembled Hyaluronic Acid Hydrogels with Tunable Stimuli Responsiveness ...................................................................730W. M. Gramlich
Patterning Bone Formation Using Proteins Derived from Seashell and Bone ........................................................................................731K. A. White, R. M. Olabisi
DC Stimulation for Spinal Fusion with a Piezoelectric Composite Material Interbody Implant: An Ovine Pilot Study ................................................................................................................................................................................................................732
L. Friis, N. Galvis, P. Arnold
Semi-resorbable Composite PMMA-Brushite Bone Cement for Spinal Augmentation ........................................................................733S. Aghyarian, E. Bentley, D. Rodrigues, J. Chari, I. Gindri, L. Rodriguez
Quantitative Assessment of Taper Damage and Head-Neck Moment Arm on Retrieved Total Hip Replacements with Modular Bore-Cone Taper Junctions..................................................................................................................................................734
C. M. Stamer, R. Taylor, P. Panigrahi, M. Harman
Role of Citric Acid on Apatite Nucleation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Aligned Nanofibers .........................................................................................................................................................................................735
D. Barati, S. R. Pajoum Shariati, S. Moeinzadeh, E. Jabbari
Effects of Heat Treatment on the Tensile Strength and Transition Temperature of Processed Collagen Devices .............................736M. Al-Rajhi, M. Diaz, A. Woodruff, G. Pomrink
Osteoblastic Stimulation Through Gene Silencing Approach Using Mesoporous Nanocarriers ..........................................................737J. Kim, M. Kang, T. Kim, S. Seo, H. Kim
PROTEINS & CELLS AT INTERFACES Extension, Locomotion, and Proliferation of Osteoblast-like Cells on Metals ........................................................................................738
P. Chen, Y. Tsutsumi, M. Ashida, H. Doi, T. Hanawa
Cellular and Gene Expression Responses in Osteoblast-like Cells to Metals ..........................................................................................739P. Chen, Y. Tsutsumi, M. Ashida, H. Doi, T. Hanawa
Bacterial Surface Display for Discovery and Study of Material Specific Peptides .................................................................................740B. L. Adams, M. Hurley, D. A. Sarkes, D. Stratis-Cullum
Nanotubular Composites Decorated on Titanium to Regulate Cell Responses.......................................................................................741H.-W. Kim, C. Mahapatra, J.-J. Kim, T.-H. Kim, K. D. Patel
RECENT ADVANCES IN SURFACE MODIFICATION OF BIOMATERIALS Methods and Reagents for Islet Surface Modification ............................................................................................................................... 742
R. R. Kane, C. Chang, J. M. Horton, M. A. Kanak, B. Naziruddin
Photoinduced and Self-initiated Grafting of 2-Methacryloyloxyethyl Phosphorylcholine to Poly(Ether-Ether-Ketone): Effects of Inorganic Salt for Shortening the Graft Polymerization Time ................................................................................743
K. Ishihara, T. Shiojima, M. Kyomoto
Surface Modification of CoCr Alloy Using Phosphoric and Phosphonoacetic Acids: Protein and Platelet Interactions......................................................................................................................................................................................................744
E. Thiruppathi, M. Larson, G. Mani
Surface Characterization and Corrosion Behavior of Silanized Magnesium Coated With Graphene for Biomedical Application ......................................................................................................................................................................................................745
M. P. Neupane, Y. K. Kim, J. H. Ji, I. S. Park, T. S. Bae, M. H. Lee
Biological Investigation of PEG-Containing Siloxane Materials by Metal-Free Click-Chemistry .......................................................746F. Lasowski, T. Rambarran, M. A. Brook, H. Sheardown
Hydroxyapatite Coating on PEEK: Material Processing, Analysis and Biocompatibility Study .........................................................747J. W. Durham III, A. Rabiei, M. J. Allen
Development of Nanoscale Hydrogel Coatings in High Speed Cell Sorting ............................................................................................748J. L. Lilly, B. J. Berron, G. Romero, W. Xu, H. Shin, V. Balasubramaniam
Light-sensitive Fluoropolymer Coated Surface for Control of Cell Adhesion Behavior........................................................................749M. Nakayama, T. Kanno, A. Kikuchi, T. Okano
Biological Tethering of N-Cadherin to Substrates Promotes Cell-Cell Adhesion ...................................................................................750J. C. M. Vega, M. K. Lee, D. E. Leckband, H. Kong
Effect of Micropattern Dimensions on Adhesion, and Nuclear Shape of Osteosarcoma Cells..............................................................751M. Ermis, D. Akkaynak, P. Chen, U. Demirci, V. Hasirci
SMALL MOLECULE DRUG DELIVERY Image-Guided Surgery for Pancreatic Neuroendocrine Tumors .............................................................................................................752
G. Park, J. H. Lee, H. S. Choi
Test Methodology of Characterizing the Behavior of Injectable Hydrogels: An In Vitro Model.........................................................753J. L. Isaacs, V. Binetti, K. Kita, A. Lowman, M. Marcolongo, G. W. Fussell
In Vivo Effects of Levonorgestrel Containing In Situ Gelling Drug Delivery Systems on Rat Pregnancy ..........................................754S. Ananthula, K. Chaudhry, D. R. Janagam, J. R. Johnson, T. Mandrell, T. L. Lowe
Conjugation of Bicyclol-Polymer Conjugates for Protecting Liver from Injury ....................................................................................755L. Wang, L. Wu, N. Li, K. Li, T. Lowe
STEM CELL AND BIOMATERIAL INTERACTIONS Assessing the Osteogenic Differentiation of Human Mesenchymal Stem Cells Co-Cultured with Human Vein Endothelial Cells on a Peptide Amphiphile Nanomatrix ...........................................................................................................................756
L. Deng, D. Patel, J. B. Vines, A. Javed, S. R. Gilbert, H. Jun
Hydrogel Microencapsulation Mimics Whole Body Response to Low Magnitude High Frequency Vibration ..................................757S. Mehta, R. M. R. Olabisi
Gold Nanoparticles Actuates Human Mesenchymal Stem Cell Differentiation Under Electric Field Stimulation ............................758G. Thrivikraman, G. Madras, B. Basu
Dynamic Extracellular Control of Mesenchymal Stem Cell Angiogenic Potential .................................................................................759A. Abdeen, J. Lee, K. Kilian
Matrix Rigidity-Modulated Cardiovascular Organoid Formation from Embryoid Bodies ..................................................................760A. Shkumatov, K. Baek, H. Kong
Susceptibility of Macroporous PHEMA Hydrogels for Growth of Mouse Embryonic Stem Cells ......................................................761O. Janouskova, M. Prádný, M. Dušková-Smrcková, K. Dušek, M. Šlouf, J. Michálek
Magnetic Field Triggered Osteogenic Differentiation of Human Mesenchymal Stem Cells on Ferromagnetic Substrates ........................................................................................................................................................................................................762
S. K. Boda, G. Thrivikraman, B. Basu
SURFACE CHARACTERIZATION & MODIFICATION Multi-Scale Surface Modification on Ti-6Al-4V Alloy by SPE process ...................................................................................................763
B. Moon, T. Jang, S. W. Kim, J. Song, H. Kim
Surface Response Model Characterizing and Predicting Selenium Nanoparticle Coatings on Medical Devices................................764M. Stolzoff, J. Bilsback, T. Webster
Comparative Study on Adsorbed and Grafted Fibronectin Coatings on Fluorocarbon Surfaces for Cardiovascular Applications.....................................................................................................................................................................................................765
V. Montaño-Machado, S. Díaz-Rodríguez, Jr., L. Hugoni, R. Tolouei, P. Chevallier, E. Pauthe, D. Mantovani
Evaluation of Protein Hydration by Vapor Sorption Methods .................................................................................................................766D. J. Burnett, M. Naderi, A. Kondor, M. Acharya
Mucoadhesive Surface Modification of PHEMA hydrogel for Ophthalmic Drug Delivery Application .............................................767L. Liu, H. D. Sheardown
A t-PA/Gold Nanoparticle Conjugate Based on Bio-affinity Ligation .....................................................................................................768Z. Tang, D. Li, H. Chen
Surface Characterization of Nanoparticles for Biomedical Applications ................................................................................................769Y. Wang, A. Rafati, D. G. Castner
Surface Modification using Polydopamine to adhere a novel anticoagulant Antithrombin-Heparin Complex to the surface of PDMS Oxygenators used as a Lung Assist Device for Neonates .............................................................................................770
D. Sandejas, J. Brash, C. Fusch, A. Chan, N. Rochow, G. Fusch, L. Berry, H. Atkinson, J. Leung, R. Cornelius, H. Matharoo, R. Selvaganapathy
TARGETED AND TARGET-ACTIVATED DRUG DELIVERY Selective Inhibition of MG-63 Osteosarcoma Cell Proliferation Induced By Curcumin-Loaded Self-assembled Arginine-Rich-RGD Nanospheres ................................................................................................................................................................771
R. Chang, L. Sun, T. J. Webster
Synthesis and In Vitro Assessment of Folate-targeted Polyamidoamine Dendrimer Gene Vector ......................................................772L. Xu, A. Yeudall, H. Yang
Folate-targeted Polyamidoamine Dendrimer for Head and Neck Cancer Gene Therapy .....................................................................773L. Xu, A. Yeudall, H. Yang
TECHNOLOGY DEVELOPMENT / NEW BIOMATERIALS FOR IMMUNE ENGINEERING Micro and Nano-patterned Surface Topographies for Control of Macrophage Form and Function ..................................................774
T. U. Luu, S. C. Gott, M. P. Rao, W. F. Liu
Self-assembled Glycopeptide Nanofibers As Synthetic Glycoprotein Mimetics to Modulate Lectin Bioactivity ................................775A. Restuccia Jr., G. A. Hudalla
THERANOSTIC NANOMATERIALS FOR IMAGE-GUIDED TREATMENTS Fibrin Glue Does Not Increase Drug Retention in the Spine.....................................................................................................................776
M. B. Giers, K. Cronk, Q. Lui, G. Ide, M. Preul, N. Theodore
Optimization of the Morphology of Multifunctional Mesoporous Silica Nanoparticles to Increase Therapeutic and Diagnostic Effects in Breast Cancer .............................................................................................................................................................777
A. L. Nelson, M. Intrator, D. Lee, J. Bardill, D. Park
Polymeric Nanoparticle-Based Enzymatically Activatable Near-Infrared Nanoprobes for Optical Detection of Cancer ..............................................................................................................................................................................................................779
T. Ozel, S. White, E. Nguyen, A. Moy, B. Choi, T. Betancourt
TISSUE ENGINEERING MC3T3 Cells Co-Cultured with Macrophages Demonstrate Enhanced Osteogenic Differentiation ...................................................780
F. Loi, R. Zhang, K. Barcay, H. Rogan, T. Lin, J. Pajarinen, C. Fan, T. Sato, J. Raphel, Z. Yao, S. Goodman
Multiple Layer Nerve Guide Using Carbon Nanotubes for Peripheral Nerve Regeneration................................................................781X. Lu, O. Yildiz, P. Bradford, M. W. King
New Bioactive Glass Fibers for Soft Tissue Regeneration .........................................................................................................................782M. T. Souza, O. Peitl, M. B. Puzzi, E. D. Zanotto
The Analysis of Residual Enzyme in the Cartilage Tissue After Partial Digestion ................................................................................783P. Lee, C. Chen, A. McNally, K. Sly, C. Chapman, S. Lin
Micro-Computed Tomography Technique to Study a Porouse Biphasic Scaffold .................................................................................784A. J. McNally, C. Chapman, K. Sly, L. Krengel, S. Lin
Microtopographical Effects on Differentiation of Embryonic Stem Cells into Cardiomyocytes ..........................................................785N. R. Patel, A. Whitehead, C. Tran, J. Newman, M. Caldorera-Moore
Protein Based Biocomposite Cryogels as Tissue Engineering Scaffolds ..................................................................................................786K. Kutuk, M. Ozmen, J. Patterson
New Blood Compatible Polymers for the Maintenance of Hepatocyte Functions to Develop Bioartificial Liver. ..............................787T. Hoshiba, T. Otaki, M. Tanaka
Effects of the Orientation of Anti-BMP2 Monoclonal Antibody Immobilized on Scaffold in Antibody Mediated Osseous Regeneration ....................................................................................................................................................................................788
H. Zadeh, S. Ansari, M. Freire, M. G. Choi, A. Tavari, A. Moshaverinia
Hybrid Nanofibers Designed to Deliver Oxygen Favorable for Cell Survival and Osteogenesis ..........................................................789H. Lee, J. Kim, S. Seo, H. Kim
Collagen Crosslinking Agent Injections to Reduce Soft Palate Vibrations in Equine Snoring .............................................................790S. Hunt, J. Kuo, T. Hedman
Strategic Design of Electrospun Fiber Scaffolds to Deliver Multiple Growth Factors for Bone Regeneration ..................................791M. S. Kang, J. J. Kim, H.-Y. Lee, J.-H. Kim, H.-W. Kim
Effect of Multi-layering of Endothelial Cell Seeded Electrospun Membranes for Vascularized Tissue Generation .........................792C. Hwang, S. Hong, H. Cho
Resveratrol Nanoparticle-incorporated Scaffolds to Modulate Inflammation and Promote Osteogenesis .........................................793K. E. Rutledge, E. Jabbarzadeh
Biomimetic Polymer Conduit for Nerve Guidance Following Peripheral Nerve Injury ........................................................................794D. J. Lee, P. Jenkins, M. R. Laughter, J. R. Bardill, A. L. Nelson, D. Park
Bioengineering Polycaprolactone Scaffolds for Growing Human Trabecular Meshwork Cells ...........................................................795J. R. Halman, K. Y. Torrejon, L. A. Beardslee, M. Bergkvist, S. T. Sharfstein, Y. Xie
VACCINE DELIVERY VEHICLES Hybrid Calcium Carbonate-Peptide Nanofiber Microparticles for Mucosal Antigen Delivery............................................................796
J. Snook, C. Chesson, A. Zloza, J. Rudra
Adjuvant Conjugated Microparticles for Vaccine Delivery: A Robust Method to Promote Immune Response ................................797K. Brink, M. V. Pishko
VASCULAR AND BLOOD CELLS RESPONSES TO NOVEL CARDIOVASCULAR BIOMATERIALS Effects of Magnesium on Endothelial Barrier Functions...........................................................................................................................799
N. Zhao, J. Ma, D. Zhu
Prohealing Multifunctional Endothelium Nanomatrix Coated Stents .....................................................................................................800G. Alexander, A. Andukuri, Y. Sohn, Y. Yoon, P. Anderson, J. Kim, B. Brott, H. Jun
Inhibition of Smooth Muscle Cell Growth by Paclitaxel Releasing Polyethylene Oxide films for Drug-Coated Balloons............................................................................................................................................................................................................801
J. Anderson, G. Mani
How Adsorbed Fibrinogen Conformation Affects Platelet Adhesion.......................................................................................................802B. J. Casey, L. Zhang, K. Vorvolakos, D. Galanakis, M. H. Rafailovich
An In Vitro Study on Early Inflammatory Response to Four Magnesium-Zinc-Strontium Alloys......................................................803A. F. Cipriano, A. Sallee, R. Guan, H. Liu
A Novel Metallic Scaffold that Promotes the Rapid Seeding of Endothelial Cells..................................................................................804M. Shayan, Y. Chun
Development of Biodegradable Elastomeric Polyurethanes with Low Initial Moduli ...........................................................................805Y. Hong, C. Xu
NaOH-etched PCLTA and mPEGA/PCLTA Networks for Regulating Smooth Muscle Cells .............................................................806X. Liu, J. Dou, S. Wang, T. Mickens
Albumin and Fibrinogen Adsorption, Platelet Adhesion and Activation on ePTFE and Electrospun PTFE .....................................807S. Lamichhane, T. Remund, M. Larson, P. Kelly, G. Mani
Hyaluronic Acid Modified Surfaces for the Reduction of the Inflammatory Response.........................................................................808J. E. Tengood, M. Reiss, J. Slee, B. Purcell, S. Caliari, R. J. Levy, J. Burdick, S. Stachelek
Fabrication and Characterization of Endothelialized Elastic Hollow Fiber Membranes As Small Diameter Vascular Grafts...............................................................................................................................................................................................809
A. E. Mercado Pagan, A. M. Stahl, M. Ramseier, A. Behn, Y. Yang
Fabrication of Human Serum Albumin Nano Films for Enhanced Hemocompatibility and Smooth Muscle Cell Response. .........................................................................................................................................................................................................810
A. Khanna, R. Burtovvy, M. Laberge, I. Luzinov, A. Simionescu
Author Index