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Spontaneous Damage to DNA
Examples of DNA Damage Induced by Radiation and Chemicals
Examples of DNA Damage Induced by Radiation and Chemicals
Direct Repair of Thymine Dimers
Not in humans
A metiltransferase é gasta nesta reacção
Base-Excision Repair
Nucleotide-Excision Repair of Thymine Dimers
Xeroderma pigmentosum
•Autosomal recessive mutations in several complementation groups
•Extreme sensitivity to sunlight
•Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)
Nucleotide excision repair - Energéticamente ineficiente
Mismatch Repair in E. coli
Teste de Ames para agentes mutagenicos