+ All Categories
Home > Documents > St. Marianna University School of Medicine -...

St. Marianna University School of Medicine -...

Date post: 23-Sep-2020
Category:
Upload: others
View: 0 times
Download: 0 times
Share this document with a friend
8
腓腖腐 膄膅腱膉腾膐膛膟臒臛 Vol. 37, pp. 125132, 2009 腕腗腜腝腙腡腉腀腂腍腘腚腇腛腅腈腜腝腟腠腊腖腞 腓腔腐腁腌腓腑腒腏腎腒腋 腄腃腆腓腔腐腋腦膩 腋腆腇腈 膚臅 腊腅腉腄 : 21 2 16 腅腁腇腃 腋腞腇腥腬膄膅腱膉腾膐膛腭膆腄腀腞膨腝膧腗腈腌腂腌腬腡腍腔腇腥膷膬臫 臱腞膪腏腠腈膑膝腞臤臱臟腝腰腙腂腔腕腊 腔腋腚腝臶腉膠臠腍腡腏臊膝膄膅腱膉腾膐膛 膟臒臛腞臙腯臕腮腑腘腂腔腕腈臊腡腙腞膷膬腞膞臉腌腑腘腂腔腕腈腡腏膥膶臷腞膫腝腨腫腒腍腘臵臥臝腞臸腝腨腪膎膥腝腨腫臘膺臬膲臁腝腟腁 腍腆腍臹臀腪腘腩膴腙腟膎膥臘臺腟膥臘 15 膊臲腯膥腝腮腐腆腝腫腥腞腞 腚腍腘膥臘腞臡腔腫膒腙腁腫腋腚腝腮腪腜 臯膘膦膛膐腟膎膥腝臊膾腛腞腨腃 腝膐腯腏腠腈腜腞腕腭腃腆1膻臑腡腙腞膎膥臷腚腉腝臣膄腀腴腀腝腖 腂腘2膩膎膥腝腏腫膛臝3臸臅膎膥 腏腫膛臝4膎膥腝腏腫膱膐膜腢臯膘膦腏腮膛腇膻臑腥膳腍腘腂腫膷膬 腼腀膄腀腞膑腖腙腁腫腝腖腂腘自腠腫腋腚腝腏腫1. 腍腎腆腂腄腋腌腒腔腏腗腊腀腉腀腈腕腑腃膄腀腴腀腚腟膥腞臑腦臏腞臢膔腏腫臗腚腍腘臮膐腇臷腝膖腏腫腥腞臞腌腬腘腈腔腇臊膾腟臃臣膨膕 腂腮腧腫臃膥臐: cytotoxic drugs 腕腊腙腜腉腺腢腥膤腣腞膠臤臻臗腵膡腞臗腌腩腝腟膗腑腞臗腚腍腘腡腙臂腂膞腜腪腖腖腁腫腋腚腯腟腎腤腝膭腍腘腅腈腔腂腜腇腩膻臑腞腚腋腭膎膥腝腅腊腫膄腀腴腀腟臑腍腜腂膻臑 CEA carcino- embryonic antigen1, 2CA19-9 3AFP a-fetopro- tein4CA72-4 5NCC-ST-439 6腜腛腇臉腌腬腘 腅腪臮腞至腙臕腌腬腘腂腫CEA 1965 腝腴腾腺腞 Gold Freedman 腝腨腪膸臨腌腬腆腩臎腥臂腉膝膙腌腬腘腈腔膄腀腴腀膶臋腞膑腖 腙腁腫腍腆腍膎膥腉腖CA19-9 腚腏腫腷腱膅膆腲腸 A 腵膆腀膂腞臌臃膹 CA 19-9CA50SPan-1腦腷腱膅膆 Tn 臃膹腵膆腀膂 CA72-4STnCA546腇臇腉膾腚腞腥臇腂腚腞臉腥腁腫腡腔CA72-4 NCC- ST-439 臸臅膎膥腙腞腇臇腉腞膄腀 腴腀腚腜腪膅膉膀腃腣膍腞膗腑腝腟腇臇腉腜腫 CEA CA19-9 腚腞腢臈腮腑腇腚臄腄腩腬膍腙腟 CEA, CA19-9AFP 腢臈腮腑腇膃膍腶臢腙腟 CA125 膖膙腚腌腬腘 腂腫腍腆腍膻臑腞腚腋腭臣膄腀腴腀腞腛腬腥 膎腒腞腂腉膇膃膆腝腍腘腂腫腚腟腂腂膩臷腝腟臲臯膘膡膓膶臋臚膯臷腇臧腙腁腪腣腍腭臩膩臷膍腞膖膑腦臩膾 腞膁腳膈腀腱腻膂腝臕腌腬腫腋腚腇臓腩腝腨腫 a4GnT 臖腯腹腀腶腻腽 腚腍腔膎膥腞臖臷膩臷膖膙腙腁腫膙 臻腆腩腟膓腌腬腘腂腫 7膎膥膕臏膻腍腘腂腫 G1cNAca1 4Ga1ß 臔膧腟膎膥 腙腥臇腽腧膻腍腘腂腫腋腚腯腖腈腚腤臌腟膎膥膣膧腨臌臃膹腞膑腖腚臞腌腬腘腂 腌腩腝G1cNAca1 4Ga1ß 臔膧腯臈臼腏腫 腨腣膍臆a4GnT 腟膎膥臏腙腥臇腽腧腁腫臜腝 a4GnTmRNA 膎膥臏 腴膍腁腫腂腟腴膍致腝膼膰腏腫膩膥腙 腒腬腓腬 80.0腇腈56.3腇腈腞臰腙膶臨腌腬膄膅腱膉腾膐膛膛膟 臯膘膦腏腮125 49
Transcript
Page 1: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

� � � ����������Vol. 37, pp. 125�132, 2009

����������� ����������������������� !"�����

������

������

� � :�� 21� 2 � 16��

����

�� �������������� ����������������������� �!�"�#$��%&� !'��()*�+,��-�./01��# 2& �����������3�45678*�+�2�)������9�4�:�78*�+��#;<=��>�?@�A�B C�8 DEF!�G"�?HI;�?@J#K��LMNO�KP@ �Q�RS$%&T)K I;J#UK';J#� 15�VW4(X );�6YQ�*@Z��[+-�8;J�\�@�])P@�-�,6H^* _�`ab���KI;�-� 2cd�?e��!4#$�^�+feQ1� gh�)�I;=.�-/�i/�jkj�l*8� 2� �AI;�-#@��F! 3� G�I;�-#@��F! 4� I;�-#@m012=.�_�`ab�n3��oghZp4�8*@��qj�j�%l)P@��l*8r$@�-�#@

1. ��� ���������������

i/�jkj-K �;�5hst6�u7�849v#@w:-�8 ;x�o=.�F!�y<#@Z�� -=z��8��o 2cK{i/>�*6|@{;}: cytotoxic drugs +,)^/?~:2F!Z����0 �w:s@�AB�w:���KCcCD�w:-�8�) E�*9��^HllP@�-4 K�X��F�8���*��^o�gh�-�fI;��,@ �2^

i/�jkjK5h�^* gh CEA carcino-embryonic antigen�1, 2� CA19-93� AFP a-fetopro-tein�4� CA72-45� NCC-ST-4396�^do�:��8�H ;x��)5<��8*@ CEAK 1965��k��� Gold- Freedman�?HB��� �1Q��Z�/G<��8���jkj<��%l)P@ �Q� I;'H�I�JK CA19-9 4KL-#@������ A��j��M�{� CA19-9 CA50 SPan-1� s���� Tn{���j�CA72-4 STn CA546� �No�/ Cc-�O�Z�*-��:ZP@ �� CA72-4 - NCC-ST-439KG�I;)�I�Jo�/F!��jkj-^HP@ ���Q@��CD�K �o�/^@ CEA - CA19-9 -�R��67oS�-���� n@�)K CEA, CA19-9 AFP �R��67o TUVu)K CA125 oS<-��8*@ �Q� gh�-�fi/�jkj�d�ZoWX�*/ ¡��Y�8*@-K**Z/ �A=.�KW[`a¢\£<� �¤¥=.o¦�)PH ��f§�]A=. @��S^s§c¨��©ª«j�¬��5<��@�-o_*m� `­��?@ a4GnT ®a~4¯j°¬±-��I;�?~=.o �A=.�S<)P@²A�Q�bc��8*@7� I;d³t6) �2��g�8*@G1cNAca1 4Ga1ß��K I;t6)Z�e��g�8*@�-4l�-X ��M�KI;�fM�{��%l-=z��8*@ ��� G1cNAca1 4Ga1ß ��4��#@M@�´g a4GnT KI;t6)Z�e��g4=X µhP@¶� a4GnTmRNA K I;t6odUP@*KdU·R¸�¹º#@�A;)Z C�»� 80.0�� 56.3���¼i)<��� I���������� ��� `ab�n3���

125

49

Page 2: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

��������������������� �� ��������������� �������������������������� ���������������� !"�#$ �pepsinogen; PG� �%&'�($)�*+�,*-�./'%&����*+���01��+��� *�*��� 23�45'67��8�� 59$:$ �;<��=��>�?@� ��� !"�#$��AB7�� C�D�EFG01��!H*,"���I���#$%���,�1��

2. ����������

�����&J�� ��'(�)* �m� KL�)*M+ �sm� ��NK�,����� O���,�'(�'$P-.QRS��-� /3�01T�O��?�� U�234K����������,5VW�?�6789�X5VW�)*67::EMR �endoscopic mucosal resection�����;1<�Y5Z�[S�89=\��]L�2004 3� ��^_�?@`>��L��89a

/bc/$�?�d EMR�?e�� @A�B,GCf�������� 2 cm g5�)*�����hD�O�� 19623?@ 19993K��iEjk$l�Fm@n�of�LG����� 3261;1�pHIq�,f��?r�� EMR ?e;1�fH� 8���Ts��� t3� 5VWuv�5VWwx��y�JK�?@LL�5VW�67:���X5VW�)*M+MN: �ESD: endoscopic sub-mucosal dissection�zE��� iEjk$l�Fm@n� O{|jk$l�G�}~P-��Q�89����]+��8, 9�� ,��jR�'�$�uZS^<�Y��T5Z�[�+,89����@� ���<�Y��T5ZU�� 4VW�uvGFX�*L ESD ���YK�+��10�� ESD�� �U+� EMR��C�@� 5VW����G�*+Z[���\��%G�5�D]^*_@�)*M+GMs`�89����� O��?@� a%� EMR ����67���b 2 cm ��]L��c*� 10 cm gd�,����@� S��[?�B,��e�?��:�f�p7��L� ��)*5��NK��������dS���f��-67?e�������r�� iEjk$l�[?�j��g@n�?��95%�&����

pHIq�?�d������h � )*��[�+� 3 cm g5���d@AiB,��e��f�H'$P-.Q� 0�� �95��CI: 0�0.3��� ��@�B,GCf��h ��S���f��-'$P-.Q� 0�� �95��CI: 0�0.4�����]L� ���)*M+�(*L������h � sm1jk �500mm�K�¡U� 3 cmg5���d 0�� �95��CI: 0�2.5������11�� O���T¢+G ESD �?e;1�*Lh � a%� EMR ��G������ 8���£s��]L� 28���K���O�lm*+[@� �����89�S�-¤¥T�O��m������ ���gn'$P-.Q��e� TY.Q��eG:4������LL�������¦U�]Lh � ���?e=\§����Go~+����1��

3. �������������

<�Y5Z�[S�po��D�89�� 67q��¨���cr��@s�� t3���bt2��>©ª����,��h@�po����@� «u�*+po��;1�cT�v:9�,*-�� ¬j<�?��^9�G�}~�*Lw^�89�����O��Af@������� 67q�po�¨����cT��^9��� x��89�­�$Ay��+��� zR����{|89}<[?�~��zE��+[�H� i5®����¯>�G°�*L���±�Fm� �median survival time: MST� �[[? 6�9²³��@� ���$%�>������ *�*��� O����^9��I*� "����53gd�Gs��+���2;1��T�O�,KL������ O���� ��89������ �^9��67q�po�¨�;1�c*+�����0����¢�v������1�����´N�?r�*+}<G��T¢����r�� 2004 3�µ&���^_�o*L��89a/bc/$�?�d� ���cT�{|��^9��*+� ¶·�4'¸­$ �5-FU ���!% c�$ �CDDP� G¹º�^9�������i5®����¯>���,����� &��­�$G��T�O������� ��]+���i5����¯�[�+t3��V���,���U� JCOG �Japan Clinical Oncology Group� ��� JCOG9912 ���¯�@� »3�i ASCO

��¼o126

50

Page 3: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

2007 �Chicago, US� ����������� A : 5FU ������� B : CPT-11�CDDP� C : S-1� 3 ������������� �!"#$� A : 2.9%&� B : 4.8%& �Hazard Ratio;0.69, p�0.001�� C : 4.2%& �Hazard Ratio; 0.75,p�0.0001� '��� B()* C �+,$ 5FU ��+,�-.�/0������� �12.�3�� 4�� 5��� �!"#$� A : 10.8%&�B : 12.3%& �Hazard Ratio; 0.85, p�0.05�� C :11.4%& �Hazard Ratio; 0.83, p�0.001�'��� B �678$9:��� �� C �;<=$

>?�� @A$ S-1+,�BC+,'.�DE�FGH�I��3F� .�.���� J�KLMNO$ S-1 ��)�P S-1�CDDP �QR,S�T�UVOWF'�XYPW�� Z5�FBC+,S�[\�$]^�3�312�� _`� abcdefghijO$� klm�nophqr� stuvgwx!y'.�lj,Sz{|�}~��3F�@A$��BC+,��:O��3�����OWF ������ ����� ����� ��� Q����/��������O$+,S��{�{���l��_O��3�3� �'x�4�� ���

� 1

� 1

�� ¡�+,�(¢F_£'¤�� ¡TS�¥� 127

51

Page 4: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

���������������� �������������������������������� � !��� 5FU �"#$%&'(#��)*+ CYP2A6� TSER� MTHFR� DPD �,-./� �SNP� +�0�113�� CDDP �(23'45��)*+ GSTP114�� CPT-11 �6789�5��)*+ UGT1A1� ABCB1� ABCC215�� SNP +�0�1:;<���=� ��:>�?�@�� �A���, ��=BCD EGFR E8F%GH#BI� �cetuximab� panitumumab� :��<�� ��A�)*� KRAS J���K���:L+�=M+:��N��=16�� ��� �OP��Q��A��RS=T��������U� +V�J���0!=,���UWX#��Q��=M+?�YZ[����=� <��� �O\�<�=M+�]�^_`_�a��bc�de�f!M+:g�+����� �

4. ����������

hi��!=j !��k"��l<�=��?� �mV 2 +nS�=� , ?� 2F7H�5

o+N��`_�k"#$� � , ?� pqr���Q_A�$�st=_t�k"#$��=�2F7H�5ouv+N�� wx�y%zH�H� &{|uv}~����uv���?��=k"'(��)!=�?�*��=� ��hi���k"�?&{|uv�]=�uuv:g����� �+q�+Q���N�,���+?��:_� �B��-�� B����&.pq�f�� �u��S��k"!=,����k"#$���&{|� ������$� �/���� �NBI: NarrowBand Imaging�:�=:sN�01k"�T���2=�?�Q�����hi$H H�6¡A�s��_t�k"#$?�¢]�lt���m_:£¤+N�¥���Q����� M�?01¦§� 0�3¨� 0�4©� 0�� 5xªp����f�«�¬�­��?¥��m����M+�®N��=� ¯°?<��,����±6���� 7:>� �²³´1� 8µ'�f����������������¶�·¸�u9!=M+:g���=�¹�?� M� 2 ��l�:º=»V� J���

2

;<¼�128

52

Page 5: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

���������� ������� ���� �� �������������������������� ���������� �� !��"#17�� ����������$����%��&�'#($�� )�*+�,$��-�.#���/0�"1� � ���234565 7DNA��89:����;���&�<�.#=�#8>?@A$���BCD�E#� � F� -�������������G��������H1I��J� ����;���G���������� H1�<�CD�� -���E#($G.� ����K1� LM�� Helicobacter Pylori NO$�-� !�PCD�E#18�21�� (DQ�R�GS�;���G89:���E#T HU�� �VNWX� YZ[\�]�� ^_�]�� �`G�a��#b�XGM��cCDdd"1� efgh5>5$���ij�kE�l��F� K�#�������������&��� mn� op.q���& MD rZ

s5tZGSuZ65� Jean-Pierre J Issa v��w�xyz{��{|}� !~������:52$$ ������22�, 23�� (����� 89:����ZNWX;��, H#�"&��($ H1��� 89:� DNA �#&�Z2:gDNA TQ��.#($G��� hf3r�f�� H1� DNA 89:������&op.#$E� ��"# �methylated genes genome-wideby hybridizing a CpG island microarray with am-

plicons obtained by the methylated CpG island

amplification technique: MCAM�� (�mn���.� ��������� ���Z2:�������� KE� �$�mn��&%#��  Z¡��¢Z£¤G¥&��K1� '¦§(¨)©`����89:�&mn.#($ H1� �{)� ª.#*«X� �]�m�Gb��"1� ��F�¨)�g5s58f¬� z��­���#�� 1������������&®+$�����¯°�±²³´$��� µ¶�,- �·� .� /

� 2

F�¸��¨) K�#¹º$»�¸����¼� 129

53

Page 6: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

�� ���������������� ����24�, 25�� ����������� DNA ����������������������� � � ��� pH1-3 ���� !��"�#��� DNA ��#�$%�&'� � �����(�)�*���+DNA�,-�� ����� � � �./01�����������2345��67845�9:;�<�=>� ��?�@A#��� BA�CDE�����)#������F)CD��G���H� I�����!"���)���CD�JKA�� ����#LM$���./%&�N)#OP�F� 'Q@A�� R�� 9:;�<(S#)*��+�J�� ����./01E� OP'Q@A�B������,-)� DNA �./)TU6VWXYZ[�\ �]0�)�01�)�� )*�123�����4�^5_�� ��J`�����67���*��a89M:� ��!b���;<�cde0"f=� g>�+?hi@A�B����@ABC�0"M:�j DRA#����>�����Rk� lE�����mFnGo=>

MCAM � ��A� 146mFnGo�� 8��*�p���#HI9DNA78qr,JI��st:u�[T53� 38mFnGo�K/)� �� 1�� BA��nGoL)� v5wxKM)���NOPQR DNA �n�6� �� yv5XYzNO�S ���DNA �n�6����#78qr,J�J�� 78qr{|q�0Tr)��+� ROC �Reciver Operating Characteristic� ��}���#U~�� �4� V\4� PPV, NPV ��H� jW9 5mFnGo�K/)� �� 2���BA� 5mFnGo���#� �� 153XY

�59q���PQRZ0��� DNA: T�20�� ���[@PQRZ0��� DNA: N�20�� ��������� DNA: W�20�� yv5XYz�S ����� DNA: EN�48�� yv5XYzS ��������DNA: EW�48����0\�J��� ]��!#�78qr{|q�0Tr)��+�ROC �Reciver Operating Characteristic� ��}���#U~�� �4� V\4� PPV, NPV ��H^��J�� �� 2� � 3����� ������M:)�DNAI�� ���Z0 2�� ./)�DNA� ���_�� R�[��XY� �GI���� @�� �MmF�)� 5nGo�78qr\ ��`4��aH� ��I MINT25 �j UA�����mFI� �4 �90���� V\4 �96���� AUC �0.961���)�� �bc�B�� Z0de������./)� gDNA ��78qr,J������#� 5mFnGo��#!�f�)#� ���������gaI��B��h��#���� ��./01E'Q)#���������� TU6VWXYZ[�\ ������B��@ g�I��B��\i@A� ���XY����-]���� _�j��XY�k����R�#��� �I���� �]� >I��¡l¢£m¤�� B�ni�o�p¥�r¦¤§¨2©qI� � ]EVªrs)#��26���tRI�� �J��� «]u��e�

�� ¬vwZ­x� yz®{1­x� |}~�1­x¯)#�r¦�°��£�3±Z²� ¥��d³5±��./R� ¡l¢£m¤�d� ���´�µ�£¤¶·� Zr¤¶·���¸­x� X¹�3m¤ MD z5w�º5�d³5±��»�£�Jean-Pierre J Issa �Z� Hyun Soo Kim �Z�

� 3

��¼J130

54

Page 7: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

Ryan J Castoro ���������

� �

1� Gold JM, Freedman SO, Gold P. Human anti-CEA antibodies detected by radioimmunoelec-

trophoresis. Nat New Biol 1972; 239: 60�62.2� Gold P, Shuster J, Freedman SO. Carcinoem-bryonic antigen �CEA� in clinical medicine: his-torical perspectives, pitfalls and projections.

Cancer 1978; 42: 1399�1405.3� Arakawa Y, Ariga H, Kano M, Matsuo Y,Honda T, Morita K. Determination and sig-

nificance of a new carbohydrate antigen CA19-

9 in digestive system cancers. Jpn J Med 1985;

24: 121�130.4� Masuzawa M, Lee PK, Kamada T, AkeyamaT, Abe H, Shimano T, Mori T, Morino H,

Ishiguro S. Carcinoembryonic antigen, alpha-

fetoprotein and carcinoplacental alkaline phos-

phatase in gastric carcinoma metastatic to the

liver. Cancer 1977; 39: 1175�1180.5� Byrne DJ, Browning MC, Cuschieri A. CA72-4: a new tumour marker for gastric cancer. Br

J Surg 1990; 77: 1010�1013.6� Ohkura H, Hattori N, Miyazaki I, Sawabu N,Tobe R, Kawai K, Abe O, Ishii M, Kawai T,

Kamano T,. �Clinical study of the NCC-ST-439 EIA kit using serum from patients with

various types of cancer and benign disease �1��.Gan To Kagaku Ryoho 1987; 14: 1901�1906.

7� Nakayama J, Yeh JC, Misra AK, Ito S, Kat-suyama T, Fukuda M. Expression cloning of a

human alpha1� 4-N-acetylglucosaminyltrans-ferase that forms GlcNAcalpha1� 4Galbeta� R, a glycan specifically expressed in the gas-tric gland mucous cell-type mucin. Proc Natl

Acad Sci U S A 1999; 96: 8991�8996.8� Kondo H, Gotoda T, Ono H, Oda I, Kozu T,Fujishiro M, Saito D, Yoshida S. Percutaneous

traction-assisted EMR by using an insulation-

tipped electrosurgical knife for early stage gas-

tric cancer. Gastrointest Endosc 2004; 59: 284�288.

9� Ono H, Kondo H, Gotoda T, Shirao K, Ya-

maguchi H, Saito D, Hosokawa K, Shimoda

T, Yoshida S. Endoscopic mucosal resection

for treatment of early gastric cancer. Gut 2001;

48: 225�229.10� Watanabe Y, Kato N, Maehata T, OkamotoM, Tsuda T, Hattori S, Yamauchi S, Fujita K,

Baba S, Nakaya S, Inaba H, Kitajima S,

Suzuki M, Niwa H, Itoh F. Safer endoscopic

gastric mucosal resection: preoperative proton

pump inhibitor administration. J Gastroen-

terol Hepatol 2006; 21: 1675�1680.11� Gotoda T, Yanagisawa A, Sasako M, Ono H,

Nakanishi Y, Shimoda T, Kato Y. Incidence

of lymph node metastasis from early gastric

cancer: estimation with a large number of cases

at two large centers. Gastric Cancer 2000; 3:

219�225.12� Wasaburo K, Tanabe S, Higuchi K, Sasaki T,

Nakayama N, Mihara S, Nakatani K,

Nishimura K, Shimoda T, Azuma M, Katada

C, Hanaoka N, Naruke A, Ryu T, Ishido K,

Saigenji K. �Clinical development of S-1 �TS-1�for advanced gastric cancer�. Gan To KagakuRyoho 2006; 33 Suppl 1: 57�63.

13� Ajani JA, Faust J, Ikeda K, Yao JC, Anbe H,Carr KL, Houghton M, Urrea P. Phase I phar-

macokinetic study of S-1 plus cisplatin in pa-

tients with advanced gastric carcinoma. J Clin

Oncol 2005; 23: 6957�6965.14� Pasello M, Michelacci F, Scionti I, HattingerCM, Zuntini M, Caccuri AM, Scotlandi K,

Picci P, Serra M. Overcoming glutathione S-

transferase P1-related cisplatin resistance in os-

teosarcoma. Cancer Res 2008; 68: 6661�6668.15� Corona G, Vaccher E, Sandron S, Sartor I,Tirelli U, Innocenti F, To#oli G. Lopinavir-

ritonavir dramatically a#ects the pharmacoki-

netics of irinotecan in HIV patients with Ka-

posi[s sarcoma. Clin Pharmacol Ther 2008; 83:

601�606.16� Di NF, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De DS, Mazzuc-

chelli L, Frattini M, Siena S, Bardelli A. Wild-

type BRAF is required for response to panitu-

�� �������������� ������ 131

55

Page 8: St. Marianna University School of Medicine - ˘ˇˆigakukai.marianna-u.ac.jp/idaishi/www/372/02-37... · 2009. 7. 1. · terol Hepatol 2006; 21: 1675 1680. 11 Gotoda T, Yanagisawa

mumab or cetuximab in metastatic colorectal

cancer. J Clin Oncol 2008; 26: 5705�5712.17� Watanabe Y, Toyota M, Kondo Y, Suzuki H,Imai T, Ohe-Toyota M, Maruyama R, Nojima

M, Sasaki Y, Sekido Y, Hiratsuka H, Shino-

mura Y, Imai K, Itoh F, Tokino T. PRDM5

identified as a target of epigenetic silencing in

colorectal and gastric cancer. Clin Cancer Res

2007; 13: 4786�4794.18� Ushijima T, Sasako M. Focus on gastric can-cer. Cancer Cell 2004; 5: 121�125.

19� Horii A, Nakatsuru S, Miyoshi Y, Ichii S,Nagase H, Kato Y, Yanagisawa A, Nakamura

Y. The APC gene, responsible for familial

adenomatous polyposis, is mutated in human

gastric cancer. Cancer Res 1992; 52: 3231�3233.20� Nanus DM, Kelsen DP, Mentle IR, Altorki N,Albino AP. Infrequent point mutations of ras

oncogenes in gastric cancers. Gastroenterology

1990; 98: 955�960.21� Maesawa C, Tamura G, Suzuki Y, OgasawaraS, Sakata K, Kashiwaba M, Satodate R. The

sequential accumulation of genetic alterations

characteristic of the colorectal adenoma-

carcinoma sequence does not occur between

gastric adenoma and adenocarcinoma. J Pa-

thol 1995; 176: 249�258.22� Estecio MR, Yan PS, Ibrahim AE, Tellez CS,Shen L, Huang TH, Issa JP. High-throughput

methylation profiling by MCA coupled to CpG

island microarray. Genome Res 2007; 17:

1529�1536.23� Estecio MR, Gharibyan V, Shen L, IbrahimAE, Doshi K, He R, Jelinek J, Yang AS, Yan

PS, Huang TH, Tajara EH, Issa JP. LINE-1

hypomethylation in cancer is highly variable

and inversely correlated with microsatellite in-

stability. PLoS ONE 2007; 2: e399.

24� Belinsky SA, Klinge DM, Dekker JD, SmithMW, Bocklage TJ, Gilliland FD, Crowell RE,

Karp DD, Stidley CA, Picchi MA. Gene pro-

moter methylation in plasma and sputum in-

creases with lung cancer risk. Clin Cancer Res

2005; 11: 6505�6511.25� Itzkowitz SH, Jandorf L, Brand R, RabeneckL, Schroy PC, III, Sontag S, Johnson D,

Skoletsky J, Durkee K, Markowitz S, Shuber

A. Improved fecal DNA test for colorectal

cancer screening. Clin Gastroenterol Hepatol

2007; 5: 111�117.26� Watanabe Y, Kim HS, Castoro R, Chung W,Estecio M, Kondo K, Guo Y, Ahmed S, Toy-

ota M, Itoh F, Suk K, Cho M, Shen L, Jelinek

J, Issa J. Sensitive and Specific Detection of

Early Gastric Cancer Using DNA Methylation

Analysis of Gastric Washes. Gastroenterology

2009; inpress.

����132

56


Recommended