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Leon Pariente: Immediate implant placement and temporization, p. 10-11 1 Elian N, Cho SC, Froum S, Smith RB, Tarnow DP. A simplified socket classification and repair technique. Pract Proced Aesthet Dent. 2007 Mar;19(2):99-104 2 Kan JY, Roe P, Rungcharassaeng K, Patel RD, Waki T, Lozada JL, Zimmerman G.; Classification of sagit-tal root position in relation to the anterior maxillary osseous housing for immediate im-plant placement: a cone beam computed tomography study. Int J Oral Maxillofac Im-plants. 2011 Jul-Aug;26(4):873-6.

Scientific review: Straumann® Pro Arch, p. 14-16 Agliardi E, Panigatti S, Clerico M, Villa C, Malo P (2010). Clin Oral Implants Res 21(5):459-465. Babbush CA, Kanawati A, Kotsakis GA, Hinrichs JE (2014). Implant Dent 23(2):218-224. Baggi L, Pastore S, Di GM, Vairo G (2013). J Prosthet Dent 109(1):9-21. Balshi TJ, Wolfinger GJ, Slauch RW, Balshi SF (2014). J Prosthodont 23(2):83-88. Begg T, Geerts GA, Gryzagoridis J (2009). Int J Oral Maxillofac Im-plants 24(4):663-671. Bellini CM, Romeo D, Galbusera F, Agliardi E, Pietrabissa R, Zampelis A et al. (2009). Int J Prosthodont 22(2):155-157. Branemark PI, Hansson BO, Adell R, Breine U, Lindstrom J, Hallen O et al. (1977). Scand J Plast Reconstr Surg Suppl 16:1-132. Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL et al. (2004). J Dent Res 83(7):529-533. De BH, Raes S, Ostman PO, Cosyn J (2014). Periodontol 2000 66(1):153-187. Douglass CW, Shih A, Ostry L (2002). J Prosthet Dent 87(1):5-8. Dye BA, Li X., Beltrán-Aguilar ED (2012). CDC: Selected Oral Health Indicators in the United States, 2005-2008 . NHCF Data Brief. Emami E, de Souza RF, Kabawat M, Feine JS (2013). Int J Dent 2013:498305.

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Eurobarometer (2010). Oral Health. Report 330. Francetti L, Romeo D, Corbella S, Taschieri S, Del FM (2012). Clin Implant Dent Relat Res 14(5):646-654. iData Re-search Inc. (2015). U.S. Market for Dental Implants, Final Abutments and Computer Guided Surgery. Idata_Usdi15_Rpt. Ikarashi Y, Toyoda K., Kobayashi E, Doi H., Yoneyama T. (2005). Materials Transactions 46(10):2260-2267. Krekmanov L, Kahn M, Rangert B, Lindstrom H (2000). Int J Oral Maxillofac Implants 15(3):405-414. Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Bosshardt DD (2011). Clin Oral Implants Res 22(4):349-356. Mack F, Schwahn C, Feine JS, Mundt T, Bernhardt O, John U et al. (2005). Int J Prosthodont 18(5):414-419. Malo P, de Araujo NM, Lopes A, Francischone C, Rigolizzo M (2012). Clin Implant Dent Relat Res 14 Suppl 1:e139-e150. Malo P, de Araujo NM, Lopes A, Moss SM, Molina GJ (2011). J Am Dent As-soc 142(3):310-320. Malo P, Friberg B, Polizzi G, Gualini F, Vighagen T, Rangert B (2003a). Clin Implant Dent Relat Res 5 Suppl 1:37-46. Malo P, Rangert B, Nobre M (2003b). Clin Implant Dent Relat Res 5 Suppl 1:2-9. Malo P, Rangert B, Nobre M (2005). Clin Implant Dent Relat Res 7 Suppl 1:S88-S94. Meredith N (1998). Int J Pros-thodont 11(5):491-501. Mericske-Stern R, Worni A (2014). Eur J Oral Implantol 7 Suppl 2:S133-S153. Molly L (2006). Clin Oral Implants Res 17 Suppl 2:124-135. Moz-zati M, Arata V, Gallesio G, Mussano F, Carossa S (2013). Clin Implant Dent Relat Res 15(3):332-340. Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J et al. (2007). Int J Oral Maxillofac Implants 22(5):755-760. Patil MS, Patil SB (2009). Gerodontology 26(1):72-77. Peltzer K, Hewlett S, Yawson AE, Moynihan P, Preet R, Wu F et al. (2014). Int J Environ Res Public Health 11(11):11308-11324. Polzer I, Schimmel M, Muller F, Biffar R (2010). Int Dent J 60(3):143-155. Schwarz F, Ferrari D, Herten M, Mihatovic I, Wieland M, Sager M et al. (2007). J Periodontol 78(11):2171-2184. Singh AV, Singh S (2014). Int J Oral Implantol Clin Res 5(1):12-23. Weinstein R, Agliardi E, Fabbro MD, Romeo D, Francetti L (2012). Clin Implant Dent Relat Res 14(3):434-441. World Health Organization (2015). 10 facts on ageing and the life course.

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Why is the Straumann CEO hanging upside down from the ceil-ing?, p. 20-23 1 Wittneben JG, Buser D, Salvi GE, Bürgin W: Complication and failure rates with im-plant-supported fixed dental prostheses and single crowns: A 10 y retrospective study. Clin Implant Dent Relat Res 2013; (E-pub ahead of print).

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Abutment selection and long-term success, p. 10-11 1 Wittneben JG, Buser D, Salvi GE, Bürgin W, Hicklin S, Brägger U. Complication and failure rates with implant-supported fixed dental prostheses and single crowns: a 10-year retrospective study. Clin Implant Dent Relat Res. 2014 Jun;16(3):356-64. 2 Giglio GD. Abutment selection in implant-supported fixed prosthodontics. Int J Periodontics Restora-tive Dent 1999;19(3):233-241. 3 Welander M, Abrahamsson I, Berglundh T. The muco-sal barrier at implant abutments of different materials. Clin Oral Implants Res. 2008 Jul;19(7):635-41. 4 Zembic A, Kim S, Zwahlen M, Kelly JR. Systematic review of the sur-vival rate and incidence of biological, technical, and esthetic complications of single im-plant abutments supporting fixed prostheses. Int J Oral Maxillofac Implants(Suppl) 2014:99-116. 5 Wittneben JG, Buser D, Belser UC, Brägger U. Peri-implant soft tissue conditioning with provisional restorations in the esthetic zone: the dynamic compression technique. Int J Periodontics Restorative Dent. 2013 Jul-Aug;33(4):447-55. 6 Jung RE, Sailer I, Hämmerle CH, Attin T, Schmidlin P. In vitro color changes of soft tissues caused by restorative materials. Int J Periodontics Restorative Dent. 2007 Jun;27(3):251-7. 7 Ka-pos T, Ashy LM, Gallucci GO, Weber HP, Wismeijer D. Computer-aided design and computer-assisted manufacturing in prosthetic implant dentistry. Int J Oral Maxillofac Im-plants. 2009;24 Suppl:110-7. 8 Sailer I, Philipp A, Zembic A, Pjetursson BE, Hämmerle CH, Zwahlen M. A systematic review of the performance of ceramic and metal implant abutments supporting fixed implant reconstructions. Clin Oral Implants Res. 2009 Sep;20 Suppl 4:4-31. 9 Zembic A, Bösch A, Jung RE, Hämmerle CH, Sailer I. Five-year results of a randomized controlled clinical trial comparing zirconia and titanium abutments sup-porting single-implant crowns in canine and posterior regions.Clin Oral Implants Res. 2013 Apr;24(4):384-90. 10 Wismeijer D, Brägger U, Evans C, Kapos T, Kelly JR, Millen C, Wittneben JG, Zembic A, Taylor TD. 11 Consensus statements and recommended clin-ical procedures regarding restorative materials and techniques for implant dentistry. Int J Oral Maxillofac Implants. 2014;29 Suppl:137-40. 12 Klotz MW, Taylor TD, Goldberg AJ. Wear at the titanium-zirconia implant-abutment interface: a pilot study. Int J Oral Maxillofac Implants. 2011 Sep-Oct;26(5):970-5. 13 van Brakel R, Meijer GJ, Verhoeven JW, Jansen J, de Putter C, Cune MS. Soft tissue response to zirconia and titanium implant abutments: an in vivo within-subject comparison. J Clin Periodontol. 2012 Oct;39(10):995-1001. 14 Degidi M, Artese L, Scarano A, Perrotti V, Gehrke P, Piattelli A. Inflammatory infiltrate, microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri-implant soft tissues around titanium and zirconium oxide healing caps. J Periodontol. 2006 Jan;77(1):73-80. 15 Nakamura K, Kanno T, Milleding P, Ortengren U. Zirconia as a dental implant abut-ment material: a systematic review. Int J Prosthodont. 2010 Jul-Aug;23(4):299-309.

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Brand matters!, p. 24-25 1 Derks J, Håkansson J, Wennström JL, Tomasi C, Larsson M, Berglundh T, Dept. of Peri-odontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg. 2 Buser D et al Clin Implant Dent Relat Res. 10-year survival and success rates of 511 tita-nium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients. 2012 Dec;14(6):839-51. 3 Roccuzzo M et al Clin Oral Im-plants Res. Long-term results of a three arms prospective cohort study on implants in peri-odontally compromised patients: 10-year data around sandblasted and acid-etched (SLA) surface. 2014 Oct;25(10):1105-12. 4 van Velzen FJ et al Clin Oral Implants Res. 10-year survival rate and the incidence of peri-implant disease of 374 titanium dental im-plants with a SLA surface: a prospective cohort study in 177 fully and partially edentulous patients.2014 Nov 5. doi: 10.1111/clr.12499. [Epub ahead of print] 5 Fischer K et al Clin Implant Dent Relat Res. Prospective 10-year cohort study based on a randomized controlled trial (RCT) on implant-supported full-arch maxillary prostheses. Part 1: sand-blasted and acid-etched implants and mucosal tissue. 2012 Dec;14(6):808-15.

Restoration of a lateral maxillar incisor, missing due to aplasia, 36-37 1 Data on file. 2 Data on file. 3 Gahlert M et al. Clin Oral Implants Res. 2012 Mar;23(3):281-6. 4 Bormann KH et al. Clin Oral Implants Res. 2012 Oct; 23(10):1210-6. 5 Data on file.

Clinical Review of the Straumann® PURE Ceramic Implant, 38-39 1 Bennadi D, Reddy CV (2013). J Int Soc Prev Community Dent 3(1):1-6. Bhandari M, Peter M.Lewis, James P.Waddell (2011). Evidence-Based Orthopedics . Oxford, UK: Wiley-Blackwell. 2 Bidra AS, Rungruanganunt P (2013). J Esthet Restor Dent 25(3):159-176. 3 Bormann KH, Gellrich NC, Kniha H, Dard M, Wieland M, Gahlert M (2012). Clin Oral Implants Res 23(10):1210-1216. 4 Buser D, Janner SF, Wittneben JG, Bragger U, Ramseier CA, Salvi GE (2012). Clin Implant Dent Relat Res 14(6):839-851. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H (1991). J Biomed Mater Res 25(7):889-902.5 Degidi M, Artese L, Scarano A, Perrotti V, Gehrke P, Piattelli A (2006). J Periodontol 77(1):73-80. 6 den Hartog L., Slater JJ, Vissink A, Meijer HJ, Raghoebar GM (2008). J Clin Periodontol 35(12):1073-1086. 7 Dubruille JH, Viguier E, Le NG, Dubruille MT, Auriol M, Le CY (1999). Int J Oral Maxillofac Implants 14(2):271-277. 8 Fischer K, Stenberg T (2011). Clin Implant Dent Relat Res. 9 Gahlert M, Kniha H, Wein-gart D, Schild S, Gellrich NC, Bormann KH (2015). submitted. 10 Gahlert M, Roehling S, Sprecher CM, Kniha H, Milz S, Bormann K (2012). Clin Oral Implants Res 23(3):281-286.11 Gahlert M, Rohling S, Wieland M, Eichhorn S, Kuchenhoff H, Kniha H (2010).

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Clin Implant Dent Relat Res 12(4):297-305. 12 Institut Straumann AG (2011). Preclinical evaluation report. Data on file 13 Institut Straumann AG (2014b). Data on File. 14 Institut Straumann AG (2014c). Patient Survey. Data on File. 15 Jung RE, Holderegger C, Sailer I, Khraisat A, Suter A, Hammerle CH (2008). Int J Periodontics Restorative Dent 28(4):357-365. 16 Klages U, Bruckner A, Zentner A (2004). Eur J Orthod 26(5):507-514. 17 Kniha K (2014). ITI World Symposium, Geneva. 18 Lindquist LW, Carlsson GE, Jemt T (1996). Clin Oral Implants Res 7(4):329-336. 19 Lotvall J, et al. (2012). Allergy 67(4):449-450. 20 Montero J, Gomez-Polo C, Santos JA, Portillo M, Lorenzo MC, Alba-ladejo A (2014). J Oral Rehabil 41(10):768-782. 21 Pithon MM, Nascimento CC, Bar-bosa GC, Coqueiro RS (2014). Am J Orthod Dentofacial Orthop 146(4):423-429. 22 Roccuzzo M, Aglietta M, Bunino M, Bonino L (2008). Clin Oral Implants Res 19(2):148-152. 23 Schultze-Mosgau S, Schliephake H, Radespiel-Troger M, Neukam FW (2000). Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89(1):91-98. Shalabi MM, Wolke JG, Jansen JA (2006). Clin Oral Implants Res 17(2):172-178. Sicilia A, Cuesta S, Coma G, Arregui I, Guisasola C, Ruiz E et al. (2008). Clin Oral Im-plants Res 19(8):823-835. 24 Simpson CR, Newton J, Hippisley-Cox J, Sheikh A (2008). J R Soc Med 101(11):558-563. 25 Tete S, Mastrangelo F, Bianchi A, Zizzari V, Scarano A (2009). Int J Oral Maxillofac Implants 24(1):52-58. 26 Thyssen JP, Menne T (2010). Chem Res Toxicol 23(2):309-318. Welander M, Abrahamsson I, Berglundh T (2008). Clin Oral Implants Res 19(7):635-641.

Long-term clinical data shows: Roxolid® works!, p. 46-47 1 Kobayashi E, Matsumoto S, Doi H, Yoneyama T, Hamanaka H. Mechanical properties of the binary titanium-zirconium alloys and their potential for biomedical materials. J Bi-omed Mater Res. 1995 Aug;29(8):943-50. 2 Bernhard N, Berner S, de Wild M, Wieland M: The binary TiZr Alloy - a newly developed Ti alloy for the use in dental implants, Fo-rum Implantol., 2009, 5, 30 -39. 3 Data on file 4 Benic G.I., Gallucci G.O., Mokti M., Hämmerle C.H., Weber H.P., Jung R.E., Titanium-zirconium narrow-diameter versus tita-nium regular diameter implants for anterior and premolar single crowns: one-year results of a randomized controlled clinical study. Journal of Clinical Periodontology 2013; [Epub ahead of print] 5 Schwarz F., et al., Bone regeneration in dehiscence-type defects at chemically modified (SLActive®) and conventional SLA® titanium implants: a pilot study in dogs. J Clin. Periodontol. 34.1 (2007): 78---86 12 Lai H.C., Zhuang L.F., Zhang Z.Y., Wieland M., Liu X., Bone apposition around two different sandblasted, large-grit and acid-etched implant surfaces at sites with coronal circumferential defects: An experimental study in dogs. Clin. Oral Impl. Res. 2009; 20(3): 247---53. 6 Buser D., Wittneben J., Bornstein M.M., Grütter L., Chappuis V., Belser U.C., Stability of contour augmentation and esthetic outcomes of implant-supported single crowns in the esthetic zone: 3-year result of a prospective study with early implant placement post extraction. J. Periodontol. 2011 March; 82(3): 342---9. 7 Buser D., Chappuis V., Kuchler U., Bornstein M.M., Witt-

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neben J.G., Buser R., Cavusoglu Y., Belser U.C., Long-term stability of early implant placement with contour augmentation. J. Dent Res. 2013 Dec; 92 (12 Suppl.): 176S-82S. 8 Nicolau P., Reis R., Guerra F., Rocha S., Tondela J., Brägger U., Immediate and early loading of Straumann® SLActive implants: A Five-Year Follow-up. Presented at the 19th Annual Scientific Meeting of the European Association of Osseointegration --- 9 October 2010, Glasgow 10 International Diabetes Federation. http://www.idf.org/diabetesatlas/ 11 6 Bo Wen et al. The osseointegration behavior of titanium-zirconium implants in ovar-iectomized rabbits. Clin Oral Implants Res. 2013 Feb 21. 12 Schlegel K.A., Prechtl C., Möst T., Seidl C., Lutz R., von Wilmowsky C., Osseointegration of SLActive® implants in diabetic pigs Clin. Oral Implants Res. 2013 Feb; 24 (2): 128---34. 13 Reginster J.Y., Bur-let N., Osteoporosis: a still increasing prevalence. Bone. 2006 Feb; 38 (2 Suppl. 1): S4-9. 14 Mardas N., Schwarz F., Petrie A., Hakimi A.R., Donos N., The effect of SLActive® surface in guided bone formation in osteoporotic-like conditions Clin. Oral Implants Res. 2011 Apr; 22 (4): 406-15. 15 WHO: www.who.int/ageing/about/facts/en/index.html 16 iData Report, Dental Implants and Final Abutments, Europe 2012 17 iData Report, Dental Implants and Final Abutments, USA 2012 18 Rupp F., Scheideler L., Olshanska N., de Wild M., Wieland M., Geis-Gerstorfer J., Enhancing surface free energy and hy-drophilicity through chemical modification of microstructured titanium implant surfaces. Journal of Biomedical Materials Research A, 76(2): 323---334, 2006. 19 De Wild M., Superhydrophilic SLActive® implants. Straumann document 151.52, 2005 20 Katharina Maniura, Laboratory for Materials --- Biology Interactions Empa, St. Gallen, Switzerland, Protein and blood adsorption on Ti and TiZr implants as a model for osseointegration, EAO 22nd Annual Scientific Meeting, October 17---19 2013, Dublin 21 Schwarz F., et al., Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive®) and conventional SLA® titanium implants: an immuno-histochemical study in dogs. J. Clin. Periodontol. 35.1 (2008): 64---75. 22 Rausch-fan X., Qu Z., Wieland M., Matejka M., Schedle A., Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to tita-nium surfaces, Dental Materials 2008 Jan.; 24(1): 102-10. Epub 2007 Apr. 27. 23 Schwarz F., Herten M., Sager M., Wieland M., Dard M., Becker J., Histological and im-munohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA® titanium implants: Preliminary results of a pilot study in dogs. Clinical Oral Implants Research, 11(4): 481---488, 2007. 24 Lang, N.P., et al., Early os-seointegration to hydrophilic and hydrophobic implant surfaces in humans, Clin. Oral Implants. Res 22.4 (2011): 349---56. 25 Raghavendra S., Wood M.C., Taylor T.D.. Int. J. Oral Maxillofac. Implants. 2005 May---Jun; 20(3): 425---31. 26 Oates T.W., Valderrama P., Bischof M., Nedir R., Jones A., Simpson J., Toutenburg H., Cochran D.L., Enhanced implant stability with a chemically modified SLA® surface: a randomized pilot study. Int. J. Oral Maxillofac. Implants. 2007; 22(5): 755---760.

It’s just the beginning, p. 48-49

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1 Bosshardt, D. Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels J Clin Periodontol 2008;35(Suppl. 8):87-105. 2 Sculean et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 2008;35:817-824. 3 McGuire MK, Scheyer ET, Nunn M J Perio 2012. 4 Hammarström L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol. 1997 Sep;24(9 Pt 2):669-77. 5 Hammarström L. The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found Symp. 1997;205:246-55; discussion 255-60. 6 Jepsen et al. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part I: Study de-sign and results for primary outcomes. J Periodontol. 2004 Aug;75(8):1150-6. 7 Sanz M, Tonetti MS, Zabalegui I, Sicilia A, Blanco J, Rebelo H, Rasperini G, Merli M, Cortellini P, Suvan JE. Treatment of intrabony defects with enamel matrix proteins or barrier mem-branes: results from a multicenter practice-based clinical trial. J Periodontol. 2004 May;75(5):726-33.

Mucosal tissue thickening around bone-level implants, p. 56-58 1 The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial. Clin. Oral Impl. Res. 0, 2013 / 1---7. 2 Puisys A, Linkevicius T. Clin Oral Implants Res. 2015 Feb;26(2):123-9. doi: 10.1111/clr.12301. Epub 2013 Dec 9. The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial. 3 Puisys A, Linkevicius T, Maslova N, Vindasiute E. The influence of mucosal tissue thicken-ing on crestal bone stability around bone level implants. Poster presented at the 20th An-nual Scientific Meeting of the European Association of Osseointegration 13-15 Oct. 2011, Athens, Greece

IDS 2015 (GERMAN SPECIAL ISSUE)

„Landmark Study‘‘ belegt: Implantatsystem ist ein wichtiger Er-folgsfaktor, p. 16-17 1 Derks J, Håkansson J, Wennström JL, Tomasi C, Larsson M, Berglundh T, Dept. of Peri-odontology, Institute of Odontology, Sahlgrenska Academy, Universität Göteborg. 2 Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Bosshardt DD. Early osseointegration

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to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Implants Res. Apr. 2011;29(4):349-56. Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG. Enhanced bone apposition to a chemically modified SLA titanium surface, J Dent Res. 2004 Jul;83 (7):529---33.

Patientenwunsch „feste Zähne’’ --- Straumann® Pro Arch, p. 18-21 1 Vierte Deutsche Mundgesundheitsstudie (DMS IV). Institut der Deutschen Zahnärzte (IDZ) im Auftrag von Bundeszahnärztekammer und Kassenzahnärztlicher Bundesvereini-gung. Nov. (2006). 2 Papaspyridakos P, Chen CJ, Chuang SK, Weber HP. Implant load-ing protocols for edentulous patients with fixed prostheses: a systematic review and meta-analysis. Int J Oral Maxillofac Implants 2014; 29 (Suppl): 256-270. 3 Rohner D. Ver-schraubte Lösungen bei nicht erhaltungswürdigem Restzahnbestand. Starget 2014; 2: 50-53. 4 Klein MO, Schiegnitz E, Al-Navas B. Systematic review on success of narrow-diameter dental implants. Int J Oral Maxillofac Implants 2014; 29 (Suppl): 43-54. 5 VOCO Structur 2 SC/QM, VOCO GmbH, Anton-Flettner-Straße 1, 27472 Cuxhaven. 6 Fangmann R, Zinser F, Holz M. Transparenz eines digitalen Behandlungskonzeptes für alle Beteiligten. digital dentistry 2014; 2: 12-20 und Oralchirurgie Journal 2014; 4: 6

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Paving the way for a patient-friendly, minimally invasive ap-proach in alveolar ridge augmentation, p. 20-23 1 Gomes KU, Carlini JL, Biron C, Rapoport A, Dedivitis RA. Use of allogeneic bone graft in maxillary reconstruction for installation of dental implants. J Oral Maxillofac Surg. 2008 Nov;66(11):2335-8. 2 Urist MR: Bone: Formation by autoinduction. Science 150:893, 1965. 3 Urist MR: Bone morphogenetic protein induced bone formation in ex-perimental animals and patients with large bone defects, in Evered D, Barnett S (eds): Cell and Molecular Biology of Vertebrate Hard Tissue. London, CIBA Foundation, 1988. 4 Schlee M, Rothamel D. (2013). Ridge augmentation using customized allogenic bone blocks: proof of concept and histological findings. Implant Dent. 2013 Jun; 22(3):212-8. 5 Dr. Markus Schlee, Dr. Yasmin Buchäckert (2013). Augmentation with a customized milled bone graft. Digital Dental News 03/2013. 6 Michele Jacotti, Carlo Barausse,

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Pietro Felice (2014). Posterior atrophic Mandible rehabilitation with onlay allograft creat-ed with CAD-CAM procedure: a case report. Implant Dent. 2014 Feb;23(1):22-8

Unlocking the full potential, p. 30-36 SBC 1 Jensen SS, Bornstein MM, Dard M, Bosshardt DD, Buser D. Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs. J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):171-81. doi: 10.1002/jbm.b.31271. PMID:19085941 2 Jensen SS, Yeo A, Dard M, Hunziker E, Schenk R, Buser D. Evaluation of a novel biphasic calcium phos-phate in standardized bone defects: a histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res. 2007 Dec;18(6):752-60. Epub 2007 Sep 20. PMID: 17888014 EMD 1 Sculean A, Alessandri R, Miron R, Salvi GE, Bosshardt DD, Enamel Matrix Proteins and Periodontal Wound healing and Regeneration, Clin Adv Per-iodontics 2011; 1:101-117 2 Sculean A, Kiss A, Miliauskaite A, Schwarz F, Arweiler NB, Hannig M. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration J Clin Periodontol. 2008 Sep;35(9):817-24. 3 Ozcelik O, Haytac MC, Seydaoglu G. Immediate post-operative effects of different periodontal treatment modalities on oral health-related quality of life: a randomized clini-cal trial. J Clin Periodontol. 2007 Sep;34(9):788-96. 4 Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol. 1997 Sep;24(9 Pt 2):693-6. 5 Gurtner GC, Werner S, Barrandon Y, Lon-gaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. 6 Al-Hezaimi K, Al-Askar M, Al-Fahad H, Al-Rasheed A, Al-Sourani N, Griffin T, O'Neill R, Javed F. Effect of enamel matrix derivative protein on the healing of standardized epithelial wounds: a histomorphometric analysis in vivo. Int Wound J. 2012 Aug;9(4):436-41. 7 Grandin HM, Gemperli AC, Dard M. Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning. Tissue Eng Part B Rev. 2012 Jun;18(3):181-202 8 Aspriello SD, Zizzi A, Spazzafumo L, Rubini C, Lorenzi T, Marzioni D, Bullon P, Piemontese M. Effects of enamel matrix derivative on vascular endothelial growth factor expression and microvessel densi-ty in gingival tissues of periodontal pocket: a comparative study. J Periodontol. 2011 Apr;82(4):606-12. 9 Zeldich E, Koren R, Dard M, Nemcovsky C, Weinreb M. Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by in-hibiting caspase activation. J Cell Physiol. 2007 Dec;213(3):750-8. 10 Straumann Bro-chure “Make a difference in more indications” 11 Lyngstadaas SP, Wohlfahrt JC, Brookes SJ, Paine ML, Snead ML, Reseland JE., Enamel matrix proteins; old molecules for new applications. Orthod Craniofac Res. 2009 Aug;12(3):243-53. 12 Almqvist S, Kleinman HK, Werthén M, Thomsen P, Agren MS, Effects of amelogenins on angiogenesis-associated processes of endothelial cells. J Wound Care. 2011 Feb;20(2):68, 70-5.

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Taking primary stability to the next level, p. 40-45 1 Millennium Report, US Markets for Dental Implants 2013 2 Bernhard et al. 2009. iData Report Dental Implants & Final Abutments Europe 2013 3 Gottlow J, Dard M, Kjellson F, Obrecht M, Sennerby L. Evaluation of a new titanium-zirconium dental implant: a biome-chanical and histological comparative study in the mini pig. Journal of Clinical Implant Dentistry and Related Research 2012; 14: 538–545. 4 Barter S, Stone P, Brägger U.: A pilot study to evaluate the success and survival rate of titanium-zirconiumimplants in par-tially edentulous patients: results after 24 months of follow-up. Clin Oral Implants Res. 2012 Jul;23(7):873–81. 5 Ganeles et al. Clin. Oral Impl. Res. 2008;19:1119-1128 6 Bornstein et al. J Periodontol. 2010 Jun;81(6):809-819 7 Oates et al. The International Journal of Oral & Maxillofacial Implants. 2007;22(5):755-760

Restoring patients’ quality of life with solutions by Straumann, p. 46-49 1 Norm ASTM F67 (states min. tensile strength of annealed titanium). Data on file for Straumann cold-worked titanium and Roxolid® Implants 2 Freiberger I., Al-Nawas B., Non-Interventional Study on Success and Survival of TiZr Implants. European Association of Osseointegration 20th Annual Scientific Meeting, Copenhagen, Denmark, October 2012: Poster presentation. Other source: Database Non-interventional study, data on file. 3 Benic G.I., Gallucci G.O., Mokti M., Hämmerle C.H., Weber H.P., Jung R.E., Titanium-zirconium narrow-diameter versus titanium regular diameter implants for anterior and premolar single crowns: one-year results of a randomized controlled clinical study. Jour-nal of Clinical Periodontology 2013; [Epub ahead of print] 4 Schwarz F., et al., Bone regeneration in dehiscence-type defects at chemically modified (SLActive®) and conven-tional SLA® titanium implants: a pilot study in dogs. J Clin. Periodontol. 34.1 (2007): 78–86 5 Lai H.C., Zhuang L.F., Zhang Z.Y., Wieland M., Liu X., Bone apposition around two different sandblasted, large-grit and acid-etched implant surfaces at sites with coronal circumferential defects: An experimental study in dogs. Clin. Oral Impl. Res. 2009; 20(3): 247–53. 6 Buser D., Wittneben J., Bornstein M.M., Grütter L., Chappuis V., Belser U.C., Stability of contour augmentation and esthetic outcomes of implant-supported single crowns in the esthetic zone: 3-year result of a prospective study with early implant place-ment post extraction. J. Periodontol. 2011 March; 82(3): 342–9. 7 Buser D., Chappuis V., Kuchler U., Bornstein M.M., Wittneben J.G., Buser R., Cavusoglu Y., Belser U.C., Long-term stability of early implant placement with contour augmentation. J. Dent Res. 2013 Dec; 92 (12 Suppl.): 176S-82S. 8 Nicolau P., Reis R., Guerra F., Rocha S., Ton-dela J., Brägger U., Immediate and early loading of Straumann® SLActive implants: A Five-Year Follow-up. Presented at the 19th Annual Scientific Meeting of the European Association of Osseointegration – 6–9 October 2010, Glasgow 9 International Diabetes Federation. http://www.idf.org/diabetesatlas/ 10 Schlegel K.A., Prechtl C., Möst T., Seidl C., Lutz R., von Wilmowsky C., Osseointegration of SLActive® implants in diabetic

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pigs Clin. Oral Implants Res. 2013 Feb; 24 (2): 128–34. 11 Reginster J.Y., Burlet N., Osteoporosis: a still increasing prevalence. Bone. 2006 Feb; 38 (2 Suppl. 1): S4-9. 12 Mardas N., Schwarz F., Petrie A., Hakimi A.R., Donos N., The effect of SLActive® sur-face in guided bone formation in osteoporotic-like conditions Clin. Oral Implants Res. 2011 Apr; 22 (4): 406-15. WHO: www.who.int/ageing/about/facts/en/index.html iData Report, Dental Implants and Final Abutments, Europe 2012 13 iData Report, Dental Implants and Final Abutments, USA 2012 Rupp F., Scheideler L., Olshanska N., de Wild M., Wieland M., Geis-Gerstorfer J., Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. Journal of Biomedical Materials Research A, 76(2): 323–334, 2006. 14 De Wild M., Superhydro-philic SLActive® implants. Straumann document 151.52, 2005 15 Katharina Maniura, Laboratory for Materials – Biology Interactions Empa, St. Gallen, Switzerland, Protein and blood adsorption on Ti and TiZr implants as a model for osseointegration, EAO 22nd Annual Scientific Meeting, October 17–19 2013, Dublin 16 Schwarz F., et al., Bone re-generation in dehiscence-type defects at non-submerged and submerged chemically mod-ified 17 (SLActive®) and conventional SLA® titanium implants: an immunohistochemical study in dogs. J. Clin. Periodontol. 35.1 (2008): 64–75. 18 Rausch-fan X., Qu Z., Wie-land M., Matejka M., Schedle A., Differentiation and cytokine synthesis of human alveo-lar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces, Dental Materials 2008 Jan.; 24(1): 102-10. Epub 2007 Apr. 27. 19 Schwarz F., Herten M., Sager M., Wieland M., Dard M., Becker J., Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA® titanium implants: Preliminary results of a pilot study in dogs. Clinical Oral Implants Research, 11(4): 481–488, 2007. 20 Lang, N.P., et al., Early osseointegration to hydro-philic and hydrophobic implant surfaces in humans, Clin. Oral Implants. Res 22.4 (2011): 349–56. 21 Raghavendra S., Wood M.C., Taylor T.D.. Int. J. Oral Maxillofac. Implants. 2005 May–Jun; 20(3): 425–31. 22 Oates T.W., Valderrama P., Bischof M., Nedir R., Jones A., Simpson J., Toutenburg H., Cochran D.L., Enhanced implant stability with a chemically modified SLA® surface: a randomized pilot study. Int. J. Oral Maxillo-fac. Implants. 2007; 22(5): 755–760.

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More than simply doing more. A partner for life., p. 18-19 1 and 2 Buser D, Janner SF, Wittneben JG, Brägger U, Ramseier CA, Salvi GE. 10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched

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surface: a retrospective study in 303 partially edentulous patients. Clin Implant Dent Relat Res 2012; 14(6):839-851.

More than an implant. A sense of trust., p. 28-33 1 1 Oates TW. et al. ‘Enhanced implant stability with a chemically modified SLA® sur-face: a randomized pilot study.’ Int. J. Oral Maxillofac. Implants. 2007; 22(5):755–760. 2 Bornstein mm et al. ‘Early loading at 21 days of non-submerged titanium implants with a chemically modified sandblasted and acid-etched surface: 3-year results of a prospec-tive study in the posterior mandible’. J. Periodontol. 2010 Jun;81 (6):809–18. 3 Buser D. et al. ‚Enhanced bone apposition to a chemically modified SLA titanium surface.’ J. Dent. Res. 2004 Jul;83(7):529–33. 4 Schwarz F. et al. ‘Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA® titanium implants: Preliminary results of a pilot study in dogs.’ Clin. Oral Impl. Res. 2007;11(4):481–488. 5 Schwarz F, et al. ‘Histological and immunohistochemical analy-sis of initial and early subepithelial connective tissue attachment at chemically modified and conventional SLA® titanium implants. A pilot study in dogs.’ Clin. Oral Impl. Res. 2007;11(3):245–455. 6 Schwarz F, et al. ‘Effects of surface hydrophilicity and microto-pography on early stages of soft and hard tissue integration at non-submerged titanium implants: An immunohistochemical study in dogs.’ J. Periodontol. 2007;78(11):2171–2184. 7 Schwarz F,et al. ‘Bone regeneration in dehiscence-type defects at chemically modified (SLActive) and conventional SLA titanium: A pilot study in dogs.’ J. Clin. Perio-dontol. 2007;34(1):78–86. 8 Zöllner et al. ’Immediate and early non-occlusal loading of Straumann implants with a chemically modified surface (SLActive®) in the posterior man-dible and maxilla: interim results from a prospective multicentre randomized-controlled study.’ Clinical Oral Implants Research, 19(5), 442-450,2008. 9 Nicolau P. et al. ‘Imme-diate and early loading of chronically modified implants in posterior jaws: 3-year results from a prospective randomized study‘ Clin Implant Dent Relat Res. 2013 Aug;15(4):600-612 10 Lang, NP. et al. ‘Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans.’ Clin Oral Implants. Res 22.4 (2011): 349–56 11 Raghavendra S, et al. Int. J. Oral Maxillofac. Implants. 2005 May–Jun;20(3):425–31. 12 Norm ASTM F67 (states min. tensile strength of annealed titanium). 13 Data on file for Straumann cold-worked titanium and Roxolid® Implants. 14 Gottlow J et al. ‘Evaluation of a new titani-um-zirconium dental implant: a biomechanical and histological comparative study in the mini pig.’ Journal of Clinical Implant Dentistry and Related Research 2012; 14: 538-545 15 Wen B et al. ‘The osseointegration behavior of titanium-zirconium implants in ovariec-tomized rabbits.’ Clin Oral Implants Res. 2013 Feb 21. 16 Barter S et al. ‘A pilot study to evaluate the success and survival rate of titanium-zirconium implants in partially edentu-lous patients: results after 24 months of follow-up.’ Clin Oral Implants Res. 2012 Jul;23(7):873-81 17 Freiberger P, Al-Nawas B. ‘Non-interventional Study on Success and Survival of TiZr Implants.’ EAO 2012 Copenhagen; 305 Posters– Implant Therapy Out-

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comes, Surgical Aspects 18 Benic GI et al. ‘Titanium-zirconium narrow-diameter versus titanium regular-diameter implants for anterior and premolar single crowns: 1-year results of a randomized controlled clinical study.’ Journal of Clinical Periodontology 2013; [Epub ahead of print].

More than PURE esthetics. The natural and strong solution., p. 34-35 1 Patientenstudie Basel-München. Abschlussbericht: Verhaltensanalysen durch Prof. Dr. Henriette Engelhardt-Wölfler, Universität Bamberg. 2 Data on file. 3 Gahlert M et al. ‚ In vivo performance of zirconia and titanium implants: a histomorphometric study in mini pig maxillae.’ Clin Oral Implants Res. 2012 Mar;23(3):281-6 4 Bormann KH et al. ‚ Bio-mechanical evaluation of a microstructured zirconia implant by a removal torque com-parison with a standard Ti-SLA implant.’ Clin Oral Implants Res. 2012 Oct; 23(10):1210-6 5 Internal data

“Short implants often provide a completely different strategy for implant placement”, p. 42-43 1 Slotte Christer et al, Four-mm implants supporting fixed partial dentures in the posterior mandible. 5-year results from a multicenter study . Presented at the 20th Annual Scientific Meeting of the European Association of Osseointegration ,10-13 October 2012, Copen-hagen, Denmark

More efficiency – more connectivity – more options, p. 48-49 1 Wittneben JG, Buser D, Salvi GE, Bürgin W: Complication and failure rates with im-plant-supported fixed dental prostheses and single crowns: A 10 y retrospective study. Clin Implant Dent Relat Res 2013; (E-pub ahead of print). Intraoral scan with 3MTM True Definition, realization with CARES®, p. 54-57 1 Giménez B, Ozcan M, Martínez-Rus F, Pardíes G: Accuracy of a digital impression system based on active wavefront sampling technology for implants considering operator experience, implant angulation and depth. Clin Implant Dent Res. 2013 Jul 24. 2 Flügge TV, Schlager S, Nelson K, Nahles S, Metzger MC: Precision of intraoral digital impres-sions with iTero and extraoral digitization with the iTero and a model scanner. Am J Or-thod Dentofacial Orthop. 2013 Sep;144(3):471-8. 3 Akyalcin S, Cozad BE, English JD,

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Colville CD, Laman S: Diagnostic accuracy of impression-free digital models. Am J Or-thod Dentofacial Orthop. 2013 Dec;144(6):916-22. 4 Hwang Y, Park Y, Kim H, Hong Y, Ahn J, Ryu J: The evaluation of working casts prepared from digital impressions. Oper Dent. 2013 Apr 9. 5 Brawek PK, Wolfart S, Endres L, Kirsten A, Reich S: The clinical ac-curacy of single crowns exclusively fabricated by digital workflow – the comparison of two systems. Clin Oral Investig. 2013 Jan 31. 6 Scotti R, Cardelli P, Baldissara P, Mona-co C: Clinical fitting of CAD/CAM zirconia single crowns generated from digital intraoral impressions based on active wavefront sampling. J Dent. 2011 Oct 17. 7 Syrek A, Reich G, Ranftl D, Klein C, Cerny B, Brodesser J: Clinical evaluation of all-ceramic crowns fab-ricated from intraoral digital impressions based on the principle of active wvefront sam-pling. J Dent 2010 Jul;38(7):553-9. 8 Degidi M, Nardi D, Piattelli A: One abutment at one time: non-removal of an immediate abutment and ist effect on bone healing around subcrestal tapered implants. Clin Oral Implants Res. 2011 Nov;22(11):1303-7. 9 Koutouzis T, Koutouzis G, Gadalla H, Neiva R: The effect of healing abutment reconnec-tion and disconnection on soft and hard peri-implant tissues: a short-term randomized controlled clinical trial. Int J Oral Maxillofac Implants. 2013 May-Jun;28(3):807-14.

New components for fixed screw-retained full-arch restorations, p. 62-65 1 Norm ASTM F67 (states min. tensile strength of annealed titanium). Data on file for Straumann cold-worked titanium and Roxolid® Implants 2 Freiberger I., Al-Nawas B. Non-Interventional Study on Success and Survival of TiZr Implants. European Association of Osseointegration 20th Annual Scientific Meeting, Copenhagen, Denmark, October 2012: Poster presentation. Other Source: Data base Non-interventional study, data on file. 3 Benic GI, Gallucci GO, Mokti M, Hämmerle CH,Weber HP, Jung RE. Titanium-zirconium narrow-diameter versus titanium regular diameter implants for anterior and premolar single crowns: 1-year results of a randomized controlled clinical study. Journal of Clinical Periodontology 2013; [Epub ahead of print] 4 Schwarz, F., et al., Bone regen-eration in dehiscence-type defects at chemically modified (SLActive®) and conventional SLA® titanium implants: a pilot study in dogs. J Clin.Periodontol. 34.1 (2007): 78–86 5 Lai HC, Zhuang LF, Zhang ZY, Wieland M, Liu X. Bone apposition around two different sandblasted, large-grit and acid-etched implant surfaces at sites with coronal circumferen-tial defects: An experimental study in dogs. Clin. Oral Impl. Res. 2009;20(3):247–53. 6 Buser D, Wittneben J, Bornstein MM, Grütter L, Chappuis V, Belser UC. Stability of Contour Augmentation and Esthetic Outcomes of Implant-Supported Single Crowns in the Esthetic Zone: 3-Year Result of a Prospective Study With Early Implant Placement Post Extraction. J Periodontol. 2011 March; 82(3): 342-9. 7 Buser D, Chappuis V, Kuchler U, Bornstein MM, Wittneben JG, Buser R, Cavusoglu Y, Belser UC. Long-term Stability of Early Implant Placement with Contour Augmentation. J Dent Res. 2013 Dec;92(12 Suppl):176S-82S. 8 Nicolau P, Reis R, Guerra F, Rocha S, Tondela J, Brägger U. Imme-

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diate and early loading of Straumann® SLActive implants: A Five Year Follow-up. Pre-sented at the 19th Annual Scientific Meeting of the European Association of Osseointe-gration – 6-9 October 2010, Glasgow 9 International Diabetes Federation. http://www.idf.org/diabetesatlas/ 10 Schlegel KA, Prechtl C,Möst T, Seidl C, Lutz R, von Wilmowsky C. Osseointegration of SLActive® implants in diabetic pigs Clin Oral Implants Res. 2013 Feb;24 (2):128-34. 11 Reginster JY, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006 Feb;38(2 Suppl 1):S4-9. 12 Mardas N, Schwarz F, Petrie A, Hakimi AR, Donos N. The effect of SLActive® surface in guided bone formation in osteo-poroticlike conditions Clin Oral Implants Res. 2011 Apr;22(4):406-15. 13 WHO: http://www.who.int/ageing/about/facts/en/index.html 14 iData Report , Dental Im-plants and Final Abutments, Europe 2012 15 iData Report , Dental Implants and Final Abutments, USA 2012 16 Rupp F, Scheideler L, Olshanska N, deWild M,WielandM, Geis-Gerstorfer J. Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. Journal of Biomedical Materials Research A, 76(2):323-334, 2006. 17 DeWild M. Superhydrophilic SLActive® implants. Straumann document 151.52, 2005 18 Katharina Maniura. Laboratory for Materials – Biology Interactions Empa, St. Gallen, Switzerland Protein and blood adsorption on Ti and TiZr implants as a model for osseointegration. EAO 22nd Annual Scientific Meeting, October 17 – 19 2013, Dublin 19 Schwarz, F., et al., Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive®) and con-ventional SLA® titanium implants: an immunohistochemical study in dogs. J Clin.Periodontol. 35.1 (2008): 64– 75. 20 Rausch-fan X, Qu Z, Wieland M, Matejka M, Schedle A. Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces. Dental Materials 2008 Jan;24(1):102-10. Epub 2007 Apr 27. 21 Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early os-seous integration at chemically modified and conventional SLA® titanium implants: Pre-liminary results of a pilot study in dogs. Clinical Oral Implants Research, 11(4): 481-488, 2007. 22 Lang, N.P., et al., Early osseointegration to hydrophilic and hydrophobic im-plant surfaces in humans. Clin Oral Implants.Res 22.4 (2011): 349–56. 23 Raghavendra S, Wood MC, Taylor TD. Int. J. Oral Maxillofac. Implants. 2005 May–Jun;20(3):425–31. 24 Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, Toutenburg H, Cochran DL. Enhanced implant stability with a chemically modified SLA® surface: a ran-domized pilot study. Int. J. Oral Maxillofac. Implants. 2007;22(5):755–760.

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Setting new standards with a broadened implant portfolio, p. 4-6 1 Data on file, used for all Straumann® cold worked titanium and Roxolid® implants 2 Norm ASTM F67 (states min. tensile strength of annealed titanium) 3 Data on file 4 Gottlow et al. Evaluation of a new titanium-zirconium dental implant: a biomechanical and histological comparative study in the mini pig. Clin Implant Dent Relat Res 2012;14:538-545. 5 Wen B et al. The osseointegration behavior of titanium-zirconium implants in ovariectomized rabbits. Clin Oral Implants Res 2013. 6 Barter, S., P. Stone, and U. Bragger A pilot study to evaluate the success and survival rate of titanium-zirconium implants in partially edentulous patients: results after 24 months of follow-up Clin.Oral Implants.Res. (2011) 7 Freiberger I., Al-Nawas B. Non-Interventional Study on Success and Survival of TiZr Implants. European Association of Osseointegration 20th Annual Scientific Meeting, Copenhagen, Denmark, October 2012: Poster presentation. 8 Thoma DS et al. Tissue integration of a new titanium-zirconium dental implant: a com-parative histologic and radiographic study in canine. J Periodontol 2011;82;1453-1461 9 Saulacic N et al. Bone apposition to a titanium-zirconium alloy implant, as compared to two titanium-containing implants. Eur Cell mater 2012;23:273-286

“Immediate implantation with the NNC implant” by Joachim S. Hermann, p. 14-17 1 COCHRAN D L, HERMANN J S: The Biology of Implant Dentistry. In: Fundamentals of Periodontics. (Eds.) Wilson T G Jr., Kornman K S, Quintessence Publishing Company, Inc., Chicago, Berlin, London, Tokyo, São Paulo, Moscow, Prague, Warsaw, Copenha-gen; vol. 2:579-588 (2003). Biological Principles in Implant Dentistry - Review Part I 2 HERMANN J S, COCHRAN D L: Biologische Prinzipien in der oralen Implantologie [Biological Principles in Implant Dentistry]. Implantologie 13 (Suppl.):109-123 (2005). Biological Principles in Implant Dentistry - Review Part 2

Esthetics – redefined and evidence-based, p. 20-23 1 Filed 2 Gahlert et al In vivo performance of zirconia and titanium implants Clin. Oral Impl. Res. 23,2012;281–286 3 Gahlert M, Röhling S, Wieland M, Eichhorn S, Küchenhoff H, Kniha H. A comparison study of the osseointegration of zirconia and tita-nium dental implants. A biomechanical evaluation in the maxilla of pigs. Clin Implant Dent Relat Res. 2010 Dec;12(4):297-305. 4 Gahlert, Weingart, Bormann: A Prospective Open Label Single Arm Study to Evaluate the Performance of Straumann Monotype Full-Ceram (Zirconium dioxide) Implants in Single Tooth Gaps in the Maxilla and Mandible (ongoing).

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“Rehabilitation of an atrophic mandible with 3D planning” by Reiner Fangmann/Lars Steinke, p. 30-35 1 Cawood JL, Howell RA. A classification oft the edentulous jaws. Int J Oral Maxillofac Surg 1988;17:232-236. 2 Acteon Germany GmbH, Industriestraße 9, D-40822 Mett-mann 3 Chiriac G, Herten M, Schwarz F, Rothamel D, Becker J. Autogenous bone chips: influence of a new piezoelectric device (Piezosurgery) on chip morphology, cell viability and differentiation. J Clin Periodontol 2005;32:994-999. 4 Stübinger S, Landes C, Saldamli, Zeilhofer H-F, Sader, R. Piezoelektrische Osteotomie in der Oralchirurgie. Quintessenz 2008;59(5):515-519. 5 Meta Advanced Medical Technology, Reggio Emili-a, Italien 6 Fangmann R. Präimplantologische Augmentation der posterioren Mandibula mit Nut Feder-Technik – Ein Fallbericht. Implantologie 2012;20(3):337-344. 7 Fangmann R. Nut-Feder-Technik. Knochenaugmentation im Unterkieferseitenzahnbereich. ZWP spe-zial 2012;10:10-15. 8 Fangmann R. Nut-Feder-Technik. Knochenaugmentation im Un-terkieferseitenzahnbereich. Implantologie Journal 2013;17(4):18-23. 9 Miratray® Implant - Hager & Werken GmbH & Co. KG, Ackerstraße 1, D-47269 Duisburg, Germany, Email: info@hagerwerken.de. 10 Tetric EvoFlow® - Ivoclar Vivadent AG, Bendererstrasse 2, FL - 9494 Schaan, Liechtenstein, Email: info@ivoclarvivadent.de. 11 Impregum™ Duo-Soft™ und Quick Polyether Abformmaterial, 3M Deutschland GmbH, Carl-Schurz-Str. 1, D-41453 Neuss 12 N. C. Lawson, D. Cakir, L. Ramp, J. O. Burgess. Flow Profile of Regu-lar and Fast-Setting Elastomeric Impression Materials Using a Shark Fin Testing Device. Journal of Esthetic and Restorative Dentistry 2011; 23 (3): 171–176. 13 Happe A, Kör-ner G, Rothamel D. Zur Problematik von submukösen Zementresten bei implantologischen Suprastrukturen und der Indikation individueller Abutments. Implantologie Journal 2011;19(2):161-169. 14 Al-Amleh B, Lyons k, Swain M. Clinical trials in zirconia: a sys-tematic review, Journal of Oral Rehabiliatation. 2010; 37, 641-652. 15 Zembic A, Sailer I, Jung R, Hämmerle C. randomized-controlled clinical trial of customized zirconia and titanium implant abutment for singl-tooth implants in canine and posterior regions: 3-years results. Clinical Oral Implants Research. 2009; 20, 802-808. 16 Trim - PEMA Temporary Resin Acrylic, Harry J. Bosworth Company.

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“ Buccal bone dehiscencies in single periodontal infections” by Guido Rhemrev, p. 28-31 1 Hürzeler MB, Weng D. A single-incision technique to harvest subepithelial connective tissue graft from the palate. Int J Periodontics Restorative Dent. 1999 Jun; 19(3): 279-87.

“Treatment of a dehiscence-type defect around a dental implant” by Mario Kirste, p. 28-31 1 Mardas N, D'Aiuto F, Mezzomo L, Arzoumanidi M, Donos N. Radiographic alveolar bone changes following ridge preservation with two different biomaterials.lin Oral Im-plants Res. 2011 Apr;22(4):416-23. 2 Mardas N, Chadha V, Donos N. Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial. 3 Stricker A, Gutwald R, Metz-ger M, Schmelzeisen R, Schnitzer S, Sauerbier. Implant survival following vertical and horizontal bone augmentation with a synthetic biphasic calcium phosphate: long-term follow-up data.EA0 2009 4 Van Assche N, Michels S,Naert I, Quirynen M. Randomized controlled trial to compare two bone substitutes in the treatment of bony dehiscences. Clin Implant Dent Relat Res. 2012 Jan 11. [Epub ahead of print] 5 Zafiropoulos GG, Hoff-mann O, Kasaj A, Willershausen B, Weiss O, Van Dyke TE. Treatment of intrabony de-fects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta-tricalcium phosphate bone substitute or bovine-derived xenograft.J Periodontol. 2007 Nov;78(11):2216-25. 6 Schmitt CM, Doering H, Schmidt T, Lutz R, Neukam FW, Schlegel KA. Histological results after maxillary sinus augmentation with Straumann® BoneCeramic, Bio-Oss®, Puros®, and autologous bone. A randomized controlled clinical trial. Clin Oral Implants Res. 2012 Feb 13. [Epub ahead of print 7 Frenken JW, Bouwman WF, Bravenboer N, Zijderveld SA, Schulten EA, ten Bruggenkate CM. The use of Straumann Bone Ceramic in a maxillary sinus floor elevation procedure: a clinical, radiological, histological and histomorphometric evaluation with a 6-month heal-ing period.Clin Oral Implants Res. 2010 Feb;21(2):201-8 8 Kirmeier R, Payer M, Boss-hardt D, Wegscheider W, Jakse N.Bone formation after sinus floor elevation using Straumann® BoneCeramic with or without autogenous bone in humans. EA0 2009. 9 Artzi Z, Weinreb M, Carmeli G, Lev-Dor R, Dard M, Nemcovsky CE.Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autoge-nous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans. Clin Oral Implants Res. 2008 Jul;19(7):686-92. Clin Oral Implants Res. 2008 Jul;19(7):686-92. 10 Cordaro L, Bosshardt DD, Palattella P, Rao W, Serino G, Chiapasco M. Maxillary sinus grafting with Bio-Oss or Straumann Bone Ceramic: histo-morphometric results from a randomized controlled multicenter clinical trial.Clin Oral Im-plants Res. 2008 Aug;19(8):796-803. 11 Froum SJ, Wallace SS, Cho SC, Elian N, Tar-now DP. Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine

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bone for sinus augmentation: 6- to 8-month postsurgical assessment of vital bone for-mation. A pilot study. Int J Periodontics Restorative Dent. 2008 Jun;28(3):273-81.

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“Restoration of an anterior tooth with a Straumann® Bone Level Implant and Guided Bone Regeneration” by Gérard Aouate, p. 32-35 1 Abrahamsson I, Berglundh T. Effects of different implant surfaces and designs on mar-ginal bone-level alterations: a review. Clin Oral Implants Res. 2009;20 Suppl 4:207-15. Review. 2 Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants. 1986;1(1):11-25. 3 Aouate G, L’implantologie non-enfouie. Issy-Les-Moulineaux : Elsevier Masson, 2008.Page 167. 4 Buser D, Wittneben J, Bornstein MM, Grütter L, Chappuis V, Belser UC. Stability of contour augmentation and esthetic outcomes of implant-supported single crowns in the esthetic zone: 3-year results of a pro-spective study with early implant placement postextraction. J Periodontol. 2011;82(3):342-9. 5 Canullo L, Fedele GR, Iannello G, Jepsen S. Platform switching and marginal bone-level alterations: the results of a randomized-controlled trial. Clin Oral Implants Res. 2010;21(1):115-21. 6 Canullo L, Pellegrini G, Götz W, La Monaca G, An-nibali S, Dellavia S Soft tissues around long-term platform-switching implant restorations in humans: histological evaluation. EAO 2010, 6-9 October 2010, Glasgow, Abstract. 7 Carlsson GE, Thilander H, Hedegård B. Histologic changes in the upper alveolar process after extractions with or without insertion of an immediate full denture.Acta Odontol Scand. 1967;25(1):21-43. 8 Chen ST, Beagle J, Jensen SS, Chiapasco M, Darby I. Con-sensus statements and recommended clinical procedures regarding surgical techniques. Int J Oral Maxillofac Implants. 2009;24 Suppl:272-8. 9 Chiapasco M, Abati S, Romeo E, Vogel G. Clinical outcome of autogenous bone blocks or guided bone regeneration with e-PTFE membranes for the reconstruction of narrow edentulous ridges. Clin Oral Implants Res. 1999;10(4):278-88. 10 Enkling N, Boslau V, Klimberg T, et al. Platform switching: a randomized clinical trial- One year results. J Dent Res 2009; 88(Spec. Issue A):3394 11 Hagiwara Y. Does platform switching really prevent crestal bone loss around implants? Jpn Dent Sci Rev 2010;46:122-131. 12 Hermann JS, Buser D, Schenk RK, Schoolfield JD, Cochran DL. Biologic Width around one- and two-piece titanium implants. Clin Oral Im-

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plants Res. 2001;12(6):559-71. 13 Hermann JS, Schoolfield JD, Nummikoski PV, Buser D, Schenk RK, Cochran DL. Crestal bone changes around titanium implants: a methodo-logic study comparing linear radiographic with histometric measurements. Int J Oral Max-illofac Implants. 2001;16(4):475-85. 14 Jung RE, Jones AA, Higginbottom FL, Wilson TG, Schoolfield J, Buser D, Hämmerle CH, Cochran DL. The influence of non-matching implant and abutment diameters on radiographic crestal bone levels in dogs. J Periodon-tol. 2008;79(2):260-70. 15 Lazzara RJ, Porter SS. Platform switching: a new concept in implant dentistry for controlling postrestorative crestal bone levels. Int J Periodontics Re-storative Dent. 2006;26(1):9-17. 16 López-Marí L, Calvo-Guirado JL, Martín-Castellote B, Gomez-Moreno G, López-Marí M. Implant platform switching concept: an updated review. Med Oral Patol Oral Cir Bucal. 2009 1;14(9):e450-4. Review. 17 Nowzari H, Chee W, Yi K, Pak M, Chung WH, Rich S. Scalloped dental implants: a retrospective analysis of radiographic and clinical outcomes of NobelPerfect implants in 6 patients. Clin Implant Dent Relat Res. 2006;8(1):1-10. Prosper L, Redaelli S, Pasi M, Zarone F, Radaelli G, Gherlone EF. A randomized prospective multicenter trial evaluating the plat-form-switching technique for the prevention of postrestorative crestal bone loss. Int J Oral Maxillofac Implants. 2009;24(2):299-308. Quirynen M, Gijbels F, Jacobs R. An infected jawbone site compromising successful osseointegration. Periodontol 2000. 2003;33:129-44. 18 Zhao G, Schwartz Z, Wieland M, Rupp F, Geis-Gerstorfer J, Cochran DL, Boyan BD. High surface energy enhances cell response to titanium substrate microstructure. J Biomed Mater Res A. 2005 1;74(1):49-58.

“Preservation of alveolar bone in an extraction socket using Straumann® MembraGel in a flapless surgical procedure” by Beat Wallkamm, p. 36-39 1 Amler MH, Johnson PL, Salman I (1960). Histological and histochemical investigation of human alveolar socket healing in undisturbed extraction wounds. Journal of the American Dental Association 61, 32-44 2 Pietrokovski J, Massler M (1967). Alveolar ridge resorp-tion following tooth extraction. Journal of Prosthetic Dentistry 17, 21-27. 3 Schropp L, Wenzel A, Kostopoulos L, Karring T (2003). Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. International Journal of Periodontics and Restorative Dentistry 23, 313-323. 4 Araujo M, Linder E, Wennstrom J, Lindhe J (2008). The influence of Bio-Oss Collagen on healing of an extraction socket: an experimental study in the dog. International Journal of Periodon-tics and Restorative Dentistry 28, 123-135. 5 Darby I, Chen ST, Buser D (2009). Ridge preservation techniques for implant therapy. International Journal of Oral and Maxillofa-cial Implants 24 Suppl, 260-271.

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“Proven over time (STL 10 years’ data)”, p. 4-13 1 Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG. Enhanced bone apposition to a chemically modified SLA titani-um surface. J Dent Res 2004;83:529-533. 2 Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, Toutenburg H, Cochran DL. Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study. Int J Oral Maxillofac Implants 2007;22:755-760. 3 Schätzle M, Männchen R, Balbach U, Hämmerle CH, Toutenburg H, Jung RE. Stability change of chemically modified sandblasted/acid-etched titanium pala-tal implants. A randomized controlled clinical trial. Clin Oral Implants Res 2009;20:489-495. 4 Fischer K, Stenberg T. Prospective 10-year cohort study based on a randomized controlled trial (RCT) on implant-supported full-arch maxillary prostheses. Part 1: sand-blasted and acid-etched implants and mucosal tissue. Clin Implant Dent Relat Res 2011;[Epub ahead of print]:doi:10.1111/j.1708-8208.2011.00389.x. 5 Buser D, Jan-ner SFM, Wittneben J-G, Brägger U, Ramseier CA, Salvi GE. 10-year survival and suc-cess rates of 511 titanium implants with a sandblasted and acid-etched surface: a retro-spective study in 303 partially edentulous patients. Clin Implant Dent Relat Res 2012;[Epub ahead of print]:doi:10.1111/j.1708-8208.2012.00456.x.

“We want to make products better and safer in dental medical technology”, p. 14-22 1 Merz BR, Hunenbart S, Belser UC. Mechanics of the implant-abutment connection: an 8-degree taper compared to a butt joint connection. Int J Oral Maxillofac Implants. 2000;15(4):519-26. 2 Norton MR. An in vitro evaluation of the strength of an internal conical interface compared to a butt joint interface in implant design. Clin Oral Impl Res 1997: 8: 290-298 3 Dibart S, Warbington M, Fan Su M, Skobe Z. In vitro evaluation of the implant-abutment bacterial seal: the locking taper system. Int J Oral Maxillofac Im-plants 2005; 20: 732-737. 4 Stanford,C.M. Achieving and maintaining predictable im-plant esthetics through the maintenance of bone around dental implants. Com-pend.Contin.Educ.Dent. 2002;23(9 Suppl 2):13-20.

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“Roxolid®: a material for new strategies in oral implantology”, p. 30-39 1 Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG. Enhanced bone apposition to a chemically modified SLA titani-um surface. J Dent Res. 2004 Jul;83(7):529-33. 2 Buser D, Martin W, Belser UC. Opti-mizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations. Int J Oral Maxillofac Implants. 2004;19 Suppl:43-61. 3 Ferguson SJ, Broggini N, Wieland M, de Wild M, Rupp F, Geis-Gerstorfer J, Cochran DL, Buser D. Biomechanical evaluation of the interfacial strength of a chemically modified sandblasted and acid-etched titanium surface. J Biomed Mater Res A. 2006 Aug;78(2):291-7. 4 Fil-lion M, Aubazac D, Allegre M, Nicolas E « How implant therapy can improve oral health related quality of life ? A cohorte prospective study ». Poster 226. Clin Oral Impl Res. Vol 21 issue No 10. October 2010 5 Gottlow, J., et al. "Evaluation of a New Titanium-Zirconium Dental Implant: A Biomechanical and Histological Comparative Study in the Mini Pig." Clin.Implant.Dent.Relat Res. (2010). 6 Hallab NJ, et al. “Corrosion and bio-compatibility of orthopaedic Implants”. In: Yaszemski MJ, Trantolo DJ, Lewandrowski K-U, Hasirci K-U, Wise DL, Altobelli DE, editors. Biomaterials in Orthopedics. UK: Informa Health Care; 2003. p 65. 7 Luongo G, Oteri G. A noninterventional study documenting use and success of implants with a new chemically modified titanium surface in daily den-tal practice. J Oral Implantol. 2010;36(4):305-14. 8 Müller F. RCT comparing titanium grade 4 vs. titanium-zirconium alloy implants in edentulous mandibles. 2-year results from a double-blind, split-mouth design study. Academy of Osseointegration 26th Annual Meeting, Washington DC, March 2011; oral presentation. www.straumann.com/AO-Washington.pdf 9 Nicolau, P., et al. "Immediate and Early Loading of Chemically Modi-fied Implants in Posterior Jaws: 3-Year Results from a Prospective Randomized Multicenter Study." Clin.Implant.Dent.Relat Res. (2011). 10 Ninomii M, “Recent research and devel-opment in titanium alloys for biomedical applications healthcare goods”. Sci Technol Adv Mater, 2003; 4:445-454 11 Oates, T. W., et al. "Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study." Int.J.Oral Maxillo-fac.Implants. 22.5 (2007): 755-60. 12 Palmer RM, Howe LC, Palmer PJ, Wilson R. A prospective clinical trial of single Astra Tech 4.0 or 5.0 diameter implants used to support two-unit cantilever bridges: results after 3 years. Clin Oral Implants Res. 2011 Mar 28. 13 Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and im-munohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res. 2007 Aug;18(4):481-8. Epub 2007 Apr 30. 14 Wall I, Donos N, Carlqvist K, Jones F, Brett P. “Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro”. Bone. 2009 Jul;45(1):17-26. Inter-view: 1 Al-Nawas, B., et al. "Comparative histomorphometry and resonance frequency analysis of implants with moderately rough surfaces in a loaded animal model." Clin Oral

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Implants.Res 19.1 (2008): 1-8. 2 Storelli, S., et al. "Three-year follow-up of a random-ized, controlled, double-blind, clinical trial comparing two different implant alloys (titani-um grade IV vs. titanium zircon) in the edentulous mandibles in a split-mouth design”, EuroPerio Presentation RC 072, June 8 2012.

“Designed for optimal mechanical debridement of metal implant surfaces affected by peri-implantitis”, p. 40-43 1 Millennium Report Dental Implants & Final Abutments Europe 2006 (page 15) and 2011 (page 11) , Millennium Report Dental Implants & Final Abutments NAM 2006 (page 11) and 2011(page 23) Millennium Research Group and Straumann internal es-timates. 2 Koller B, Att W, Strub JR. Survival rates of teeth, implants, and double crown-retained removable dental prostheses: a systematic literature review. Int J Prosthodont. 2011 Mar-Apr;24(2):109-17. 3 Mombelli, A. "Microbiology and antimicrobial therapy of peri-implantitis," Periodontology 2000 2002;28:177–189 4 Data on file: Bench test of TiBrush – P1.245-001V 5 Compared to metal curettes 6 Frank Schwarz. More efficient and effective - Cleaning efficiency on contaminated titanium discs. Publication under re-view at Clin Oral Invest. (data on file: P1.245-008V).

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“Advances in periodontology and periodontal regeneration (In-terview with D. Cochran”, p. 4-15 1 American Academy of Periodontology Position Paper, Periodontal Regeneration, J Peri-odontal 2005; 76:1601-1622. 2 Yilmaz et al. Healing of two and three wall intrabony periodontal defects following treatment with an enamel matrix derivative combined with autogenous bone J Clin Periodontol 2010;37(6):544-50. 3 Aspriello et al. Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery. Clin Oral Investig 2011; 15(2):225-32. 4 Trombelli and Farina. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration J Clin Periodontol 2008;35(8Suppl):117-35. 5 Cochran et al. The effect of enamel matrix proteins on peri-odontal regeneration as determined by histological analyses. J Periodontol 2003;74:1043-1055. 6 Thoma et al. Angiogenic activity of an enamel matrix derivative

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(EMD) and EMD-derived proteins: an experimental study in mice J Clin Periodontol 2011;38(3):253-260. 7 Kauvar et al. In Vivo Angiogenic Activity of Enamel Matrix De-rivative. J Periodontol 2010:81(8)1196-201. 8 Johnson et al Cellular Effects of Enamel Matrix Derivative Are Associated With Different Molecular Weight Fractions Following Separation by Size-Exclusion Chromatography. J Periodontol 2009;80(4):648-656. 9 Emerton et al. Regeneration of Periodontal Tissues in Non-human Primates with rhGDF-5 and Beta-Tricalcium Phosphate J Dent Res 2011 90(12):1416-1421. 10 Cochran. Perio-dontology in the age of inflammation: a changing landscape. J Am Coll Dent 2009; 76(1):23-26; 11 Cochran. Inflammation and Bone Loss in Periodontal Disease J Perio-dontol 2008:79(8Sup):1569-1576. 12 Cochran et al. Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. Periodontol 2003;74:1269-1281. 13 Boyan et al. Porcine Fetal Enamel Matrix Derivative Enhances Bone Formation Induced by Demineralized Freeze Dried Bone Allograft In Vivo J Perio-dontol 2000 ; 71 :1278-1286. 14 Cochran et al. Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: A histometric study in the canine mandible J Biomed Mater Res 1998;40(1) :1-11 15 Trombelli L, Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol 2008;35 (Suppl 8):117 – 135. 16 Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardi-ovascular disease and stroke. A systematic review. Ann Periodontol. 2003 Dec:8(1):38-53. 17 RC Williams. Understanding and managing periodontal diseases: a notable past, a promising future. J Periodontol 2008 Aug, 79(8 Suppl.):1552-9. 18 Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007 Oct; 13 Suppl 4:30-10. 19 Alten-hoevel A, Norman K, Smoliner C, Peroz I. The impact of self perceived masticatory func-tion on nutrition and gastrointestinal complaints in the elderly. J Nutr Health Aging 2012 Feb; 16(2):175-8. 20 Teeuw W.J., Gerdes V.E.A., Loos B.G. (2010) Effect of Periodon-tal Treatment on Glycemic Control of Diabetic Patients. A systemic review and meta-analysis. Diabetes Care Vol. 33, No. 2 Feb 2010 421-427.

Jonathan Fleiner, Andres Stricker and Dirk Schulze: Straumann® coPeriodontiX™ – three-dimensional digital bone measurement using cross-sectional DVT image data in parodontological issues, p. 24-28 1 Eley, B. M. & Cox, S. W. Advances in periodontal diagnosis. 2 Traditional clinical methods of diagnosis, Br Dent J, 1998; 1: 12–16. 2 Pepelassi, E. A. & Diamanti-Kipioti, A. Selection of the most accurate method of conventional radiography for the assessment of periodontal osseous destruction, J Clin Periodontol, 1997; 8: 557–567. 3 Mol, A. Im-aging methods in periodontology, Periodontol 2000, 2004: 34–48. 4 Hashimoto, K. et

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al. A comparison of a new limited cone beam computed tomography machine for dental use with a multidetector row helical CT machine, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2003; 3: 371–377. 5 Scarfe, W. C., Farman, A. G. & Sukovic, P. Clinical applications of cone-beam computed tomography in dental practice, J Can Dent Assoc, 2006; 1: 75–80. 6 Vandenberghe, B., Jacobs, R. & Yang, J. Detection of periodontal bone loss using digital intraoral and cone beam computed tomography images: an in vitro assessment of bony and/or infrabony defects, Dentomaxillofac Radiol, 2008; 5: 252–260. 7 Akesson, L., Hakansson, J. & Rohlin, M. Comparison of panoramic and in-traoral radiography and pocket probing for the measurement of the marginal bone level, J Clin Periodontol, 1992; 5: 326–332. 8 Vandenberghe, B., Jacobs, R. & Yang, J. Diag-nostic validity (or acuity) of 2D CCD versus 3D CBCT-images for assessing periodontal breakdown, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007; 3: 395–401. 9 Misch, K. A., Yi, E. S. & Sarment, D. P. Accuracy of cone beam computed tomography for periodontal defect measurements, J Periodontol, 2006; 7: 1261–1266. 10 Mengel, R., Candir, M., Shiratori, K. & Flores-de-Jacoby, L. Digital volume tomography in the di-agnosis of periodontal defects: an in vitro study on native pig and human mandibles, J Periodontol, 2005; 5: 665–673. 11 Farman, A. G. & Farman, T. T. A comparison of 18 different x-ray detectors currently used in dentistry, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005; 4: 485–489. 12 Kasaj, A. & Willershausen, B. Digital volume to-mography for diagnostics in periodontology, Int J Comput Dent, 2007; 2: 155–168. 13 Sogur, E., Baksi, B. G. & Grondahl, H. G. Imaging of root canal fillings: a comparison of subjective image quality between limited cone-beam CT, storage phosphor and film radi-ography, Int Endod J, 2007; 3: 179–185. 14 Ludlow, J. B., Davies-Ludlow, L. E. & Brooks, S. L. Dosimetry of two extraoral direct digital imaging devices: NewTom cone beam CT and Orthophos Plus DS panoramic unit, Dentomaxillofac Radiol, 2003; 4: 229–234. 15 Hirsch, E., Wolf, U., Heinicke, F. & Silva, M. A. Dosimetry of the cone beam computed tomography Veraviewepocs 3D compared with the 3D Accuitomo in different fields of view, Dentomaxillofac Radiol, 2008; 5: 268–273. 16 Schulze, D., Heiland, M., Thurmann, H. & Adam, G. Radiation exposure during midfacial imaging using 4- and 16-slice computed tomography, cone beam computed tomography systems and conven-tional radiography, Dentomaxillofac Radiol, 2004; 2: 83–86. 17 Ludlow, J. B. & Ivanov-ic, M. Comparative dosimetry of dental CBCT devices and 64-slice CT for oral and maxil-lofacial radiology, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008; 1: 106–114. 18 Tsiklakis, K. et al. Dose reduction in maxillofacial imaging using low dose Cone Beam CT, Eur J Radiol, 2005; 3: 413–417. 19 Noujeim, M., Prihoda, T., Langlais, R. & Nummikoski, P. Evaluation of high-resolution cone beam computed tomography in the detection of simulated interradicular bone lesions, Dentomaxillofac Radiol, 2009; 3: 156–162. 20 Stratemann, S. A., Huang, J. C., Maki, K., Miller, A. J. & Hatcher, D. C. Com-parison of cone beam computed tomography imaging with physical measures, Den-tomaxillofac Radiol, 2008; 2: 80–93. 21 Brown, A. A., Scarfe, W. C., Scheetz, J. P., Silveira, A. M. & Farman, A. G. Linear accuracy of cone beam CT derived 3D images, Angle Orthod, 2009; 1: 150–157. 22 Fleiner, J., Hannig C., Schulze, D., Stricker, A.,

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Jacobs, R., Digital method for quantification of circumferential periodontal bone level us-ing cone beam CT, Clin Oral Investig, 2012; [Epub ahead of print].

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The Straumann® Standard Plus Narrow Neck Crossfit® Implant line, p. 6-15 1 Compared with the Straumann® Narrow Neck Portfolio. 2 Fischer K. ITI World Sympo-sium. 2010 15.-17. April, Geneva, Switzerland. 3 Gottlow J et al. Präklinische Daten vorgestellt beim 23. Jahreskongress der Academy of Osseointegration (AO), Boston, und beim 17. Wissenschaftlichen Jahreskongress der European Association for Osseointegra-tion (EAO), Warschau. 4 Barter S, Stone P, Brägger U. A pilot study to evaluate the suc-cess and survival rate of titanium-zirconium implants in partially edentulous patients: re-sults after 24 months of follow-up. Clin Oral Implants Res. 2011 Jun 24. doi: 10.1111/j.1600-0501.2011.02231.x 5 Al-Nawas B, A Double-Blind Randomized Con-trolled Trial (RCT) of Titanium-13Zirconium versus Titanium Grade IV Small-Diameter Bone Level Implants in Edentulous Mandibles – Results from a 1-Year Observation Period, Clinical Implant Dentistry and Related Research, 2011 Mar 17 6 Norm ASTM F67 (gibt Mindestzugfestigkeit von geglühtem Titan an) für alle Straumann Titan- und Roxolid-Implantate verwendet, Daten in Akten. 7 Biomechanische Tests durchgeführt gemäss ISO 14.801, Daten in Akten für Roxolid® und Roxolid® NNC. 8 Ganeles J, Zöllner A, Jackowski J, ten Bruggenkate C, Beagle J, Guerra F. Immediate and early loading of Straumann implants with a chemically modified surface (SLActive®) in the posterior man-dible and maxilla: 1-year results from a prospective multicenter study. Clin. Oral Impl. Res. 2008;19:1119–1128.

Frank Bröseler: Interview and clinical case report, p. 22-32 1 Friedmann A, Gissel K, Soudan M, Kleber B-M, Pitaru S, Dietrich T. Randomized con-trolled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound. J Clin Peridontol 2011; 38: 677–685. doi: 10.1111/j.1600-051X.2011.01738.x.2 Zitzmann NU, Naef R, Schärer P. Resorbable Versus Nonresorbable Membranes in Combination With Bio-Oss for Guided Bone Re-

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generation. JOMI 1997 Vol. 12, No. 6 (844 - 852). 3 Buddy Ratner. Biomaterials sci-ence: an introduction to materials in medicine. Elsevier Academic Press 2004, p.121. 4 Geurs NC, Korostoff JM, Vassilopoulos PJ, Kang T-H, Jeffcoat M, Kellar R, Reddy MS. Clinical and Histologic Assessment of Lateral Alveolar Ridge Augmentation Using a Syn-thetic Long-Term Bioabsorbable Membrane and an Allograft. J Periodontol 2008; 79(7): 1133-1140. 5 Dahlin C, Lekholm U, Becker W, Becker B, Higuchi K, Callens A, van Steenberghe D. Treatment of Fenestration and Dehiscence Bone Defects Around Oral Im-plants Using the Guided Tissue Regeneration Technique: A Prospective Multicenter Study. Int J Oral Maxillofac Implants 1995;10:312–318 6 Jovanovic SA, Spiekermann H, Rich-ter J. Bone Regeneration Around Titanium Dental Implants in Dehisced Defect Sites: A Clinical Study. INT J ORAL MAXILLOFAC IMPLANTS 1992;7; 233-245. 7 Jung, R.E., Hälg, G.A., Thoma, D.S., Hämmerle, C.H.F. (2009) A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants. Clin. Oral Impl. Res. 20: 162–168. Clinical case report: 1 Jung, R.E., Hälg, G.A., Tho-ma, D.S., Hämmerle, C.H.F. (2009) A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants. Clin. Oral Impl. Res. 20: 162–168. 2 Gottlow, J., Nyman, S., Karring, T., Lindhe, J. (1984) New attach-ment formation as the result of controlled tissue regeneration. Journal of Clinical Perio-dontology 11: 494–503. 3 Nyman, S.R., Lang, N.P. (1994) Guided tissue regeneration and dental implants. Periodontology 2000 4: 109–118. 4 Zitzmann, N.U., Naef, R., Schärer, P. (1997) Resorbable versus nonresorbable membranes in combination with Bio-Oss for guided bone regeneration. International Journal of Oral & Maxillofacial Implants 12: 844–852. 5 Hämmerle, C.H.F., Lang, N.P. (2001) Single stage surgery combining transmucosal implant placement with guided bone regeneration and bioresorbable mate-rials. Clinical Oral Implants Research 12: 9–18. 6 Jung, R.E., Glauser, R., Schärer, P., Hämmerle, C.H.F., Weber, F.E. (2003) The effect of rhBMP-2 on guided bone regenera-tion in humans. A randomized, controlled clinical and histomorphometric study. Clinical Oral Implants Research 14: 556–568. 7 Moses, O., Pitaru, S., Artzi, Z., Nemcovsky, C.E. (2005) Healing of dehiscence-type defects in implants placed together with different bar-rier membranes: a comparative clinical study. Clinical Oral Implants Research 16: 210–219. 8 Tietmann, C., Bröseler, F. (2009) Ridge Augmentation using bovine-derived Xen-ograft prior to Implant Placement in the Esthetic Zone. Journal of Clinical Periodontology 36 (Suppl. 9), 217 #683. 9 Working, P.K., Newman, M.S., Johnson, J., Cornacoff, J.B. (1997) Safety of poly(ethylene glycol) and poly(ethylene glycol) derivatives. In: Zalipsky SJ, Harris JM, editors. Poly(ethylene glycol), Chemistry and Biological Applications. Washington DC: American Chemical Society: 45–57. 10 Vaage, J., Donovan, D., Uster, P., Working, P. (1997) Tumour uptake of doxorubicin in polyethylene glycol-coated lipo-somes and their therapeutic effect against a xenografted human pancreatic carcinoma. British Journal of Cancer 75: 482–486. 11 Mettler, L., Audebert, A., Lehmann-Willenbrock, E., Schive, K., Jacobs, V.R. (2003) Prospective clinical trial of SprayGel as a barrier to adhesion formation: an interim analysis. Journal of the American Association of Gynecologic Laparoscopists 10: 339–344. 12 Cosgrove, G.R., Delashaw, J.B., Grotenhuis, J.A., Tew, J.M., Van Loveren, H., Spetzler, R.F., Payner, T., Rosseau, G.,

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Shaffrey, M.E., Hopkins, L.N., Byrne, R., Norbash, A. (2007) Safety and efficacy of a novel polyethylene glycol hydrogel sealant for watertight dural repair. Journal of Neuro-surgery 106(1): 52-58. 13 Jung, R.E., Zwahlen, R., Weber, F.E., Molenberg, A., van Lenthe, G.H. & Hämmerle, C.H.F. (2006) Evaluation of an in situ formed synthetic hydro-gel as a biodegradable membrane for guided bone regeneration. Clinical Oral Implants Research 17: 426–433. 14 Wechsler, S., Fehr, D., Molenberg, A., Raeber, G., Schense, J.C.,Weber, F.E. (2007) A novel, tissue occlusive poly(ethylene glycol) hydrogel material. Journal of Biomedical Materials Research 85A: 285–292. 15 Schwarz, F., Mihatovic, I., Golubovic, V., Hegewald A., Becker, J. (2011) Influence of two barrier membranes on staged guided bone regeneration and osseointegration of titanium implants in dogs: part 1. Augmentation using bone graft substitutes and autogenous bone. Clinical Oral Im-plants Research Apr. 25: doi: 10.1111/j.1600-0501.2011.02187.x

Interview with Anton Sculean, p. 34-39 1 Holm-Pedersen P, Lang NP, Mu¨ ller F. What are the longevities of teeth and oral im-plants? Clin. Oral Impl. Res. 18 (Suppl. 3), 2007; 15–19 2 Tonetti et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects - A multicentre randomized controlled clinical trial J Clin Periodontology 2002;29; 317-325 3 Cairo F, Pagliaro U, Nieri M. Treatment of gingival recession with coronally advanced flap procedures: a sys-tematic review. J Clin Periodontol 2008;35 (Suppl 8):136 – 162. 4 Sculean et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 2008;35: 817 – 824.

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Dental Explorer 3D, p. 46-51 (English version only) AMMANN, A. & MATTHIES, H.K. (2008). K-Space DentMed/Visual Library: Generating and Presenting Dynamic Knowledge Space for Dental Research, Education, Clinical and Laboratory Practice. Proc. of World Conference on Educational Multimedia, Hypermedia and Telecommunications 2008. 5542-5548. Chesapeake, VA: AACE.

The Straumann® Standard Plus Narrow Neck CrossFit® Implant

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1 GOTTLOW J et al. Preclinical data presented at the 23rd Annual Meeting of the Acad-emy of Osseointegration (AO) in Boston and at the 17th Annual Scientific Meeting of the European Association for Osseointegration (EAO) in Warsaw. 2 Standard ASTM F67 (states min. tensile strength of annealed titanium). Data on file, used for all Straumann® titanium and Roxolid® implants.

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Trend and innovation in bone regeneration, p. 21-25 1 Wissenschaftliche Datenlage zum synthetischen Knochenersatzmaterial Straumann® BoneCeramic (Stand: September 2009). Auszug aus einem Gutachten zur Frage der Eig-nung von Straumann® BoneCeramic als Knochenersatzmaterial vom 10. Juni 2009 erstellt durch Univ.-Prof. Dr. Dr. W. Wagner, Dr. Dr. M.O. Klein, Klinik für Mund-, Kiefer- und Gesichtschirurgie der Universität Mainz. Hinweis: Das Dokument kann bei der Institut Straumann AG in Basel/Schweiz angefordert werden. 2 S. J. FROUM, S. S. WALLACE, S.C. CHO, N. ELIAN, D. P.TARNOW. Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6- to 8- month postsurgical assessment of vital bone formation. A pilot study. Int. J. Periodontics Restorative Dent. 2008; 28: 273-281 3 DOROZHKIN SVEPPLE M. Die biologische und medizinische Bedeutung von Calciumphosphaten. Angewandte Chemie, 2002. 114: p. 3260-3277. 4 KOHRI M, MIKI K, WAITE DE, NAKAJIMA HOKABE T. In vitro stability of biphasic calci-um phosphate ceramics. Biomaterials, 1993. 14(4): p. 299-304. 5 DACULSI, G., WEISS, P., BOULER, J.M., GAUTHIER, O., MILLOT, F. & AGUADO, E. (1999a) Biphasic calcium phosphate/hydrosoluble polymer composites: a new concept for bone and dental substi-tution biomaterials. Bone 25 (2 Suppl): 59S–61S. 6 SCHOPPER, C., ZIYA-GHAZVINI, F., GORIWODA, W. MOSER, D., WANSCHITZ, F., 7 SPASSOVA, E., LAGOGIANNIS G., AUTERITH, A. & EWERS, R. (2005) HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation – a long-term histological study. Jour-nal of Biomedical Materials Research Part B: Applied Biomaterials 74: 458–467. 8 N. MARDAS ET AL. Socket preservation with synthetic bone substitute or bovine xenograft. 9 Poster IADR 2008 (study CR 03/05 data on file) G.-G. K. Zafiropoulos et al. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta tricalcium phosphate bone substitute or bovine-derived xenograft. Periodontol 2007; 78 : 2216-2225 10 CORDARO L. ET AL. Maxillary

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sinus grafting with Bio-Oss*® or Straumann® BoneCeramic: histomorphometric results from a randomized controlled multicenter clinical trial. Clin. Oral Impl. Res. 19, 2008; 796–803 11 Z. ARTZI ET AL. Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxylapatite/biphasic trical-cium phosphate graft materials: at 6 and 9 months in humans. Clin. Oral Impl. Res. 2008; 19: 686-692 13 ZAFIROPOULOS G.-G. K. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydrox-ylapatite/beta tricalcium phosphate bone substitute or bovine-derived xenograft. J. Perio-dontol 2007; 78: 2216-2225 12 N. VAN ASSCHE. Evaluation of bone fill in buccal de-hiscences around dental implants after augmentation with synthetic, biphasic calcium phosphate or bovine hydroxylapatite. Abstract 053, Short oral presentations EAO 2007 (Study CR 04/05. data on file) 13 LINDGREN C, MORDENFELD A, HALLMAN M. Clin Implant Dent Relat Res. 2010 May 11. A Prospective 1-Year Clinical and Radiographic Study of Implants Placed after Maxillary Sinus Floor Augmentation with Synthetic Biphasic Calcium Phosphate or Deproteinized Bovine.