Stay Informed: November 2017 BOARD OF DIRECTORS PRESIDENT Mary Min-Chin Lee, MD Worcester, MA PRESIDENT-ELECT Philip Zeitler, MD, PhD Aurora, CO SECRETARY John S. Fuqua, MD Indianapolis, IN TREASURER Peter Lee, MD, PhD Hershey, PA PAST PRESIDENT Stephen Rosenthal, MD San Francisco, CA AT LARGE DIRECTORS Dorothy Shulman, MD Tampa, FL Madhu Misra, MD, MPH Boston, MA Michael Levine, MD Philadelphia, PA PES Management Team Executive Director Maureen Thompson Senior Association Manager Janice Wilkins Association Manager Brandi Walsh SAVE THE DATE for the PES annual Meeting! May 5-8, 2018 Toronto, Canada Greetings! The newsletter this month is full of news that is relevant for your work. Please note the consensus statements and other work produced by our highly productive committees below. While it seems as if we just finished the international meeting, our program committee has already planned a fantastic program for the upcoming meeting! Registration and housing are now open for the 2018 PAS/PES meeting in Toronto, Canada. Our “home hotel” is the Westin Harbour Castle Hotel. Don’t forget to submit your abstracts and register early to qualify for the early bird fees! We are so appreciative of the members who agreed to run for our elected positions and thank those of you who took time to vote. Election results are below--please congratulate your newly elected representatives to PES leadership positions! For those of you who follow US traditions and celebrated Thanksgiving last week, I hope you had a safe and enjoyable holiday with your family and friends. As we approach the busy holiday season, please remember to pay your PES dues. Along with paying your PES dues we ask you please consider making a tax deductable donation to support the work of the society. Important note: We have recently updated our demographic questionnaire that goes along with the dues renewal in order to know who you are so that we can make the most informed decisions when developing new programs and resources. Therefore, even if you are paying by check or if you are an emeritus or honorary member, please use the link below so that you can be sure your member information is up-to-date. During our strategic planning this past year, we realized that the field of pediatric endocrinology has undergone changes and our members' careers may have shifted in recent years. We would like to update and understand your current work settings and responsibilities to better tailor resources and initiatives to meet your needs. On behalf of the membership committee and the board of directors, we are requesting that you fill out the demographic questionnaire attached to your dues renewal so we have a more accurate picture of our members. PES 2018-2019 Election Results President-Elect: Erica Eugster, MD Secretary: Mitch Geffner, MD Director: Philippe Backeljauw, MD Welcome New Members First Name Last Name Organization Carmen Lucia Bustamante Escobar Jackson Memorial Hospital Rida Javaid UPMC Liya Kerem MGH Christine March Children's Hospital of Pittsburgh Kyle McNerney Washington University Abby Meyers NIH/CNMC Kate Millington Boston Children’s Hospital Rebecca Persky National Institutes of Health
Transcript
Stay Informed: November 2017 BOARD OF DIRECTORS
PRESIDENT Mary Min-Chin Lee, MD
Worcester, MA
PRESIDENT-ELECT Philip Zeitler, MD, PhD
Aurora, CO
SECRETARY John S. Fuqua, MD
Indianapolis, IN
TREASURER Peter Lee, MD, PhD
Hershey, PA
PAST PRESIDENT Stephen Rosenthal, MD
San Francisco, CA
AT LARGE DIRECTORS Dorothy Shulman, MD
Tampa, FL
Madhu Misra, MD, MPH
Boston, MA
Michael Levine, MD
Philadelphia, PA
PES Management Team Executive Director
Maureen Thompson
Senior Association Manager
Janice Wilkins
Association Manager
Brandi Walsh
SAVE THE DATE for the PES annual Meeting! May 5-8, 2018 Toronto, Canada
Greetings! The newsletter this month is full of news that is relevant for your work. Please note the consensus statements and other work produced by our highly productive committees below. While it seems as if we just finished the international meeting, our program committee has already planned a fantastic program for the upcoming meeting! Registration and housing are now open for the 2018 PAS/PES meeting in Toronto, Canada. Our “home hotel” is the Westin Harbour Castle Hotel. Don’t forget to submit your abstracts and register early to qualify for the early bird fees! We are so appreciative of the members who agreed to run for our elected positions and thank those of you who took time to vote. Election results are below--please congratulate your newly elected representatives to PES leadership positions! For those of you who follow US traditions and celebrated Thanksgiving last week, I hope you had a safe and enjoyable holiday with your family and friends. As we approach the busy holiday season, please remember to pay your PES dues. Along with paying your PES dues we ask you please consider making a tax deductable donation to support the work of the society.
Important note: We have recently updated our demographic questionnaire that goes along with
the dues renewal in order to know who you are so that we can make the most informed decisions
when developing new programs and resources. Therefore, even if you are paying by check or if
you are an emeritus or honorary member, please use the link below so that you can be sure your
member information is up-to-date.
During our strategic planning this past year, we realized that the field of pediatric endocrinology
has undergone changes and our members' careers may have shifted in recent years. We would
like to update and understand your current work settings and responsibilities to better tailor
resources and initiatives to meet your needs. On behalf of the membership committee and the
board of directors, we are requesting that you fill out the demographic questionnaire attached to
your dues renewal so we have a more accurate picture of our members.
PES 2018-2019 Election Results President-Elect: Erica Eugster, MD Secretary: Mitch Geffner, MD Director: Philippe Backeljauw, MD Welcome New Members
First Name Last Name Organization
Carmen Lucia Bustamante Escobar Jackson Memorial Hospital
Elizabeth Rosenfeld Children's Hospital of Philadelphia
Mohamed Saleh Children's Hospital of Pittsburgh
Physicians Recommend Individualized, Multi-disciplinary Care for Children Born 'Intersex' In conjunction with the Societies for Pediatric Urology, the American Association of Clinical Urologists, the American Association of Pediatric Urologists, and the Society of Academic Urologists, the Pediatric Endocrine Society has prepared a response to the recent Human Rights Watch on urological surgeries for children in the United States. The response affirms our belief in individualized, multi-disciplinary care for children born with DSD. The complete statement is available from the Societies for Pediatric Urology. http://spuonline.org/HRW-interACT-physicians-review/ Recommendations from D&T: GnRHa Statement A concern has been raised regarding prolonged QT interval occurring in men with prostate cancer being treated with GnRHa. Please read the recommendations of our D&T committee as it relates to pediatric endocrine patients receiving this therapy. https://www.pedsendo.org/education_training/healthcare_providers/consensus_statements/assets/Risk_of_Prolonged_QT_Interval_with_GnRHa.pdf T1DOP - Publication of Manuscript A committee of individuals representing each society with interest in Diabetes was formed over 2 years ago with the goal of “expanding the clinical and research goals that pertain to Diabetes.” After reviewing 100s of articles through a series of conference calls and in-person meetings, the committee came to the following definitions in the link below. To promote acceptance of these definitions, JDRF is working with several of the committee members and the FDA. Their goal is to embrace newer technologies and target goals that have been accepted by this committee to ensure that future research, drug development and technology uses the same criteria for better comparison. The publication can be found here. Publication of the consensus on T1D outcomes is a major milestone of the T1D Outcomes Program. But, there is more work to be done to ensure full adoption of the outcomes by decision-makers. Below are several areas where PES has been asked to help.
1. For any research you are a part of, please encourage utilization of the outcomes in clinical trials as defined in the publication.
2. For those organizations who issue clinical guidelines, we’ll be following up with you about incorporation of the outcomes in those guidelines.
3. When you have opportunities to speak publicly about the outcomes using the standardized slide decks (see final versions attached), please keep us informed about these engagements (workshops, conferences, etc.) so that we can track these activities for reference.
One of the keys to ensuring the success of this effort and effecting change is for these evidence based consensus outcomes to be recognized by decision-makers as the standard of care for patients with type 1 diabetes. For example, when outcomes such as hypoglycemia and time in range are being used to assess approval of a therapy or insurance coverage decisions, we want the information to reflect the consensus statement. The actions noted above will help achieve this as we continue to engage with decision-makers about adoption of the outcomes for the benefit of people with T1D. Spring retreat applications now open! The Spring Retreat is for first and second year fellows who are PES members. The Retreat is held annually in conjunction with the Pediatric Academic Sciences (PAS)/PES meeting. The goals of the Spring Retreat are to develop and practice critical thinking skills in clinical Pediatric Endocrinology, learn about different career options within the field, and network with other fellows and faculty. Fellows will present cases to an audience of faculty and peers, learn from nationally recognized faculty, and have fun in the process. Click here to apply Deadline: January 11, 2018 PES Travel Awards – Apply Now!
Click here to apply Deadline: March 15, 2018 PES International Scholar Award Do you know a young pediatrician or pediatric endocrinologist in a resource- limited country who would like to gain experience or specific skills in your clinic or lab? Are you interested in hosting such a person at your institution? The PES is now accepting applications for the PES International Scholar Award. The award is designed for pediatric colleagues interested in endocrinology to visit and work in the clinics and laboratories of PES members and to attend the PES annual meeting, with a particular goal of helping younger colleagues and individuals from countries with disadvantaged economies. The deadline for applications is April 1, 2018 for 2019 awards for the applicant to be in North America in the spring of 2019. Please visit the link below for details. https://www.pedsendo.org/research_awards/international_scholars/ If you have questions, please email the International Scholar Committee Chair: Jadranka Popovic MD, E-mail: [email protected] World Diabetes Day/Diabetes Month In honor of World Diabetes Day, Nov 14, 2017, we are highlighting the work of “Life for a Child USA”, a branch of the International Diabetes Foundation that trains local health care workers and provides insulin, syringes, strips, meters and educational material to approximately 18,000 youth with diabetes in 40 developing countries. In association with World Diabetes Day/Diabetes month, this organization is conducting a 1000 donor campaign, asking for 1000 donors to commit to a dollar/day allowing them to support diabetes-related needs for children in need. The web site lifeforachildusa.org/1000donors provides information about the campaign as well as details about this organization. Historic Tidbit provided by Dr. Alan D. Rogol Growth and the pituitary The pituitary’s role in growth was established in 1886 by the association of acromegaly with pituitary tumor [P Marie, Rev Med (Paris) 6:297]. S Crowe, et al. associated the cessation of growth with hypophysectomy in puppies [Bull Johns Hopkins Hosp 21:127, 1910]. Evans and Long [Anat Red 21:62, 1921] and noted increased growth in rats following injection of an extract of anterior lobes. PE Smith showed that normal growth required the anterior pituitary [Am J Anat 45:205, 1930 (renamed Developmental Dynamics in 1992)]. Daily anterior pituitary homeotransplants restored normal growth in hypophysectomized rats; but intraperitoneal injections of aqueous pituitary extracts had no effect on the atrophied reproductive organs. Growth hormone is water-soluble, but gonadotropins are not. Clinical Update Course Registration - Open Soon! Looking for the most up to date information on the care of transgender youth? Want to know more about fertility in survivors of childhood cancer? PES has partnered with our colleagues in the Canadian Pediatric Endocrine Group to bring you the 2018 Clinical Update and Case Discussion Course. The day will include key sessions on clinical areas of great relevance to your daily practice, and the frequently requested hot topics including: • Practical tips for starting patients on closed-loop insulin delivery systems • Management of type 2 diabetes beyond metformin • Clinical Genetics for the pediatric endocrinologist- what test, when and why? • and so much more! This year it will be a single day course on Friday, May 4, 2018 (7am-4:30pm) the day before the main PAS/PES meeting starts and will take place at the Westin Harbour Castle Hotel in Toronto. This course will be an excellent clinical practice complement to the research science presented at the main meeting, and we hope you can attend. Registration will open early December – please check the PES website for more information and schedule coming soon! Image of the month Solitary median maxillary central incisor syndrome (SMMCI) The SMMCI tooth erupts precisely in the midline of the maxillary dental arch in both primary and
permanent dentitions. Congenital nasal malformation (choanal atresia, midnasal stenosis or congenital pyriform aperture stenosis) and holoprosencephaly may be associated with SMMCI. Common congenital anomalies are intellectual disability, congenital heart disease, cleft lip and/or palate, microcephaly, hypopituitarism, hypotelorism, strabismus, esophageal and duodenal atresia, cervical hemivertebrae, cervical dermoid, scoliosis, and absent kidney. A missense mutation in the SHH gene at 7q36 may be associated with SMMCI (1). The 8 year old girl in the picture was delivered at 30 weeks gestation due to critical aortic stenosis in the mother. Her course was complicated by hypotension, hypothyroxinemia and hypoglycemia with mid-face hypoplasia leading to a diagnosis of pan- anterior hypopituitarism. She walks independently but does not speak.
Click here to view this month’s image. ICPE Guidelines-call for volunteers The Pediatric Endocrine Society is a member of the International Consortium of Pediatric Endocrinology (ICPE). One of ICPE’s roles is to facilitate the development of global practice guidelines, including worldwide input from Pediatric Endocrinology societies (PES, ESPE, SLEP, APPES, etc.). Recent examples of these guidelines have included updates on DSD and adolescent PCOS. We are currently looking for PES members to work with representatives from our global sister societies on new practice guidelines. The following topics are available:
Update on GnRH analogs for the treatment of precocious puberty Secondary adrenal insufficiency after long-term treatment with synthetic glucocorticoids,
including aspects pertaining to critical illness The management of endocrine problems of children and adolescents with beta
thalassemia Consensus statement on the management of the child born small for gestational age
through to adulthood Work on each of these guidelines should commence this spring and will likely continue for a year or more, with one or more face-to-face meetings. If you would like to nominate yourself or someone else to represent PES on any of these working groups, please send us the individual’s name and a paragraph describing his or her qualifications to work on the specific topic. Nominations are due by January 31, 2018. We will consider all submitted names and reach decisions on each topic by the end of February 2018. Please email [email protected]. HRP journal member survey summary and basic instructions on how to access the journal as a PES member As the initial three-year contract with Karger/Hormone Research in Paediatrics (HRP) approaches its December 31, 2017 endpoint, PES has undertaken an evaluation of the initial three-year relationship that has included an administrative review by Maureen Thompson from Degnon, a scientific review by Mitch Geffner and the members of the Communications (formerly Publications) Committee, and an analysis of a survey that was sent to the PES membership. The reviews and survey analysis were also vetted by the PES Board of Directors. The overall evaluation was quite favorable with several (mostly) administrative points that need to be addressed related to: (1) availability of the latest issue; (2) accessing articles through the log-in; (3) problems receiving the journal via e-mail and paper subscription renewal notifications; (4) details re succession of all editorial posts; (5) commissions re paid advertisements; and (6) the number of non-PES members needed for review of submitted manuscripts. Pediatric Endocrinology Papers of Interest The publications committee reviews and provides links to papers of interest quarterly. One article will be from a recent volume of Hormone Research in Paediatrics (HRP). The other article is selected from an outside journal. The two articles selected by the committee are listed below with links to the full article following the citation. HRP: Garcia-Filion P, Almarzouki H, Fink C, Geffner M, Nelson M, Borchert M. Brain malformations do not predict hypopituitarism in young children with optic nerve hypoplasia. Horm Res Paediatr 2017;88:251-257. Summary: Optic nerve hypoplasia (ONH), a leading cause of pediatric blindness, is associated with brain malformations and hypopituitarism in the constellation known as septo-optic dysplasia. Neuroimaging has historically been used to predict hypopituitarism. In a prospective neuro-imaging study of the association of hypopituitarism with brain malformations, hypopituitarism and brain malformations were highly prevalent, but had unrelated associations with ONH. Abnormal pituitary imaging predicted pituitary dysfunction in 100% (13 patients), however,
hypopituitarism was present in 87 of 133 patients with an intact pituitary on imaging. Thus, brain MRI in infants and toddlers with ONH is not a helpful screening tool for hypopituitarism risk. Click here to view the full article. Non-HRP: NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 2017;Oct 10. Summary: The aim of this paper was to estimate worldwide trends in mean body mass index (BMI) and develop a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare observed trends with those of adults. The results show that the increasing trends in children's and adolescents' BMI have plateaued in many high-income countries at high levels, but have accelerated in parts of Asia, with trends no longer correlated with those of adults. Click here to view the full article. Clinical Scholar and Research Fellowship Awards now open! Applications for the 2018 Research Fellowship Awards and Clinical Scholar Awards are now open! Please click on the links below to access the detailed instructions, requirements, and the applications. PES Research Fellowship Awards PES Clinical Scholar Awards The Deadline is January 16, 2018, 5:00 PM (Eastern) Registration and housing now open for the PES/PAS Meeting! Meeting May 5-8, 2018, Toronto, Canada Click here to register. Click here to secure lodging. Obituary - J.Rodman Seely
J.Rodman Seely, a founding member of the Lawson Wilkins Pediatric Endocrine Society, known for his career in both pediatric endocrinology and genetics died on 27th October in Oklahoma City at the age of 90 years. He was known and is remembered for his compassionate teaching and leadership style. He graduated from the University of Utah majoring in Biology and graduating with honors in 1950, from the University of Utah as Doctor of Medicine (MD), interned in pediatrics in Salt Lake City, and completed residency and fellowship in the Department of Pediatrics at the University of Utah College of Medicine at the Salt Lake General Hospital. He joined the Department of Pediatrics at the University of Washington School
of Medicine as Research Assistant Professor in 1958. He then completed his Doctor of Philosophy (PhD) thesis on “Adrenocortical Function in Newborn Humans: Methodology and Circulating Steroid Patterns”. In 1964 he was appointed Associate Professor in The Endocrinology and Metabolism Section in the Department of Pediatrics at the University of Oklahoma with adjunct appointments in Cytotechnology and Biochemistry. He is survived by his second wife Susan Holmes Seely of thirty-one years and his three daughters, Diana Decker; Lynn Seely Ditzler MD and Tricia Denison; and nine grandchildren. Lynn followed Rodman’s footsteps in pursuing a medical career graduating in 1985, completing her residency in internal medicine at Yale and her endocrinology fellowship at the University of California San Diego where she joined the faculty. We extend sympathy to the family for their loss.
Sincerely,
Mary Min-Chin Lee, MD Dorothy Shulman, MD
PES President PES Board Member
Pediatric Endocrine Society 6728 Old McLean Village Drive, McLean VA, 22101
