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An Overview of Early Development modeled with Play-Dough
Fertilized egg
Totipotentstem cells
Totipotent: Can become any cell in body or placenta
Fate Decision
Pluripotentstem cells(3-5 days old)
Blastocyst
Pluripotent: Can become any cell in body
Implantation
Fate DecisionGastrulation (day 14) leads toPrimary Germ CellsEndoderm (inner)digestive tract, resp. trackMesoderm (middle)bones, blood cells, heartEctoderm (outer)skin, CNS
Multipotent: Can become any cell within a specific germ layer or cell lineage
Embryonic stem cells come from inner cell mass of blastocyst.
Implantation
Fate DecisionGastrulation (day 14) leads toPrimary Germ CellsEndoderm (inner)digestive tract, resp. trackMesoderm (middle)bones, blood cells, heartEctoderm (outer)skin, CNS
Multipotent: Can become any cell within a specific germ layer or cell lineage
Multipotent
Four-cell stage 2 days after fertilization
Source: Florida Institute for Reproductive Science and Technologies
Eight-cell stage3 days after fertilization
Courtesy: RWJMS IVF Program
Source: Florida Institute for Reproductive Science and Technologies
Morula 4 days after fertilization 16 cells
Source: Florida Institute for Reproductive Science and Technologies
Blastula5 days after fertilization
Courtesy: RWJMS IVF Program
Source: Florida Institute for Reproductive Science and Technologies
http://www.luc.edu/depts/biology/dev/urchindv.htm (courtesy of Dr. J. Hardin, Univ. of Wisconsin) http://www.exploratorium.edu/imaging_station/gallery.php?Asset=celldiv&Category=seaurchins&Type=video
Sea Urchin DevelopmentOne Cell to Blastula Stage