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Induces Dbx1 cells Dbx2 cells Txn of Wnt Igf2 GLI-1 PDGFRα Ptc-1 Txn of Myc Axin CycD1 TGF-1 PPARγ CD44 MMP-7 etc. Vertebrates Fly DELTA1 DELTA2 DELTA3 DELTA4 JAGGED1 JAGGED2 CONTACTIN NB3 DELTA SERRATE LAG2 DSL1 C. elegans NOTCH NOTCH TACE NEXT LRP5/6 DALLY DALLY - LIKE MEGALIN HIP NICD NICD NICD CycC, cdk8 MAML HATS Hairless Act-Ci Cos2 SuFu SuFu SuFu SuFu SuFu Repressor Complex Fly Vertebrates Hes 1/3/5 PreTα Hey1/Hey2 MAG CNPase CBP, RBPjk (vertebrate) Su(H) (Fly) Lag 1 (C.elegans) +Fbw7/Sel10 Proteosomal degradation ? CtBP Slimb KIF Slimb Rep-Ci Fu Act-Ci Act-Ci Act-Ci Cos2 SuFu Fu cAMP PS1/PS2 PEN-2 APH -1 +shh -shh Smo Ptc Shh SKN GAS-1 Dhh Ihh Cadherin FZ P P P Ub UbUb Ub Proteosomal degradation Palmitate Cholesterol NCT WNT β-catenin β-catenin β-catenin β-catenin β-catenin α-catenin GBP/Frat p120 CK1 PP2A GSK3B PKA PKA CK1 5gg GSK3B Axin Pygo XSox17 BCC9 CtBP Groucho SKIP Syn3a CIR SMRT CtBP LEF/TCF LEF/TCF APC Wnt Cerberus WIF Dkk Frp AKT Dsh naked GLI-2 GLI-1 GLI-3 Groucho CtBP CSL P P P P P CSL CSL P P + Notch pathway shh pathway wnt/β-catenin pathway NUCLEUS Neurogenesis Signaling Pathways: Notch | Shh | β-catenin
