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Stem Cell Therapy in DogsA New Treatment for a New Decade
Presented by Vet-Stem
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What are Stem Cells?Stem Cells are primitive cells present in almost every tissue
• Self Renewing
• Able to become different tissue types
• Signal other cells to come in and rescue and repair
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What Do Adult Stem Cells Do?
10 million cells die in your body every minute of
every day.
Your stem cells replace them so you can continue living.
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Embryonic vs Adult Stem Cells
Embryonic Stem Cells
• Intended to form whole animal - not for repair• Can form tumors – UNPREDICTABLE• Ethical dilemma• Maybe someday
Adult Stem Cells – many sources
• Intended for self repair• No ethical dilemma• Do not form tumors when injected• Available now
Gruen L and Grabel L, Stem Cell 2006;24;2162-2169.
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Why Fat as Stem Cell Source?
• High healing cell count – No culturing
required
• 1000 times more stem cells than bone
marrow
• Family of healing cells
• Rapid, Easy to access
• Over 1700 peer reviewed papers published
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6
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What Do Stem Cells Do?
• Reduce Inflammation
• Reduce pain
• Differentiation into tissue
• Home in on injury sites
• Induce healing-regeneration
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The Injury Response Cascade
Time
Fibrosis
Inflammation
“Regeneration”
Acute InjuryAcute Injury Scar Complete
Ma
gn
itu
de
QUICK QUICK FIXFIX
Courtesy of Dr.Caplan, Case Western Reserve
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“Regeneration”
Acute InjuryAcute Injury Scar Reduced
Time
Ma
gn
itu
de
Inflammation
Fibrosis
Stem Cells in Injury Response
Courtesy of Dr. Caplan, Case Western Reserve
Stem CellsStem Cells
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Annie
Annie 9 yr LabX
Chronic elbow arthritis
Drugs not controlling pain
Stem Cell Therapy
Able to jump in and out of car; took 2 hour run in the woods 90 days after stem cell therapy
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Harley 6 yr Rat terrier
Pain in hips & knees since 6 months old
Pain killer medications (NSAIDS) for 12 months & still painful
Wouldn’t play ball or go up stairs
2 weeks after stem cells– Dramatic pain reduction
Plays ball and climbs stairs
Now NSAID free for >36 months
Harley
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Blinded Clinical Trial Participant
Cinnamon 10 yr Standard Poodle
Arthritis in both hips
Unable/unwilling to take medications
Owners considering euthanasia-got a new puppy
30 days after stem cell therapy he was playing, jumping, running and taking long walks
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Got Fat?
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Why Use Vet-Stem?
• Began treating horses in 2003
• Experienced-Over 3,500 horses & 2,000
dogs
• Safety-your pet’s own cells
• Strict quality standards
• Peer-reviewed, published controlled studies
• Global leader in veterinary stem cell therapy
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Horses:7/3,359 (0.2%) Only local swelling/pain
Dog: 2/1,695 (0.1%) Only local swelling/pain
*probable adverse events, through 6/1/09
Safety Profile*
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• Written standard operating procedures
• Independent Quality Assurance Unit
• Routine audits of all procedures
• Sample release criteria
• Formal training systems
Quality Standards
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Service Overview
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Vet-Stem Adipose Processing Lab
1. Immediate use
3. Lifetime supply by culture
2. Frozen for future
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Current Supported UsesDogs/Cats
• Osteoarthritis• Polyarthritis• Tendonitis• Ligament injury
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Pet w/ lameness or pain due to arthritis or a partial tear of a ligament or tendon
Pet does not require surgery – surgery first, if needed
No other major diseases (liver, kidney, heart)
No major spinal disease (spondylosis, spinal arthritis)
Not-responsive or can’t tolerate pain killers
Realistic expectations
Ideal Stem Cell Case
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Cruciate Ligament Disease & Stem Cells
• Surgery – always have surgery when required
• With surgery – helps to reduce inflammation and scar tissue
• After surgery – helps to treat inflammation and encourage cartilage repair
• Chronic ACL inflammation and synovitis is a good case
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Storm
Storm 9yr Catahoula Leopard Dog Mix
Arthritis in both hips and right stifle
Unable/unwilling to take medications
3 weeks after treatment started showing improvement
Later his left stifle was treated after surgical repair
Storm and owners happy that he is doing extremely well
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Real World Dog OA Cases
24
Average Veterinary Scores of Dogs in Regards to Pain, Lameness, and Range of Motion
2008 Commercial Clinical Data*
1.0
1.5
2.0
2.5
3.0
3.5
Pain(N=141, pre-tx)
Lameness(N=146, pre-tx)
Range Of Motion(N=141, pre-tx)
Ve
teri
na
ry S
co
re
Veterinary Scale:5=Extreme (considering euthanasia)4=Severe3=Moderate2=Mild1=Normal
*Voluntary responses from commercial cases.
Day 0 30 60 90 Day 0 30 60 90 Day 0 30 60 90
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Conclusion: According to a 2009 Owner Survey
• Greater than 33% of dogs discontinued the use of NSAIDs completely
• Greater than 28% of dogs decreased their dependency on NSAIDs
At 90 and 246 days after treatment
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Why Vet-Stem is the Only Choice for
Quality and Experience
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• Never collect fat again. Grow more cells as needed. Some clinics have to collect fat repeatedly.
• Precise cell counts. Some clinics inject unknown numbers of cells.
• Excellent safety record with thousands of dogs.
• Controlled lab for stem cell processing instead of processing in the clinic in the presence of hair and other potential contaminants.
• Vet-Stem implements FDA guidelines to ensure quality. Some in-clinic kits are labeled “kit to be used for research”.
Malibu
Before and After Video
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Media Coverage of Veterinary Medicine
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Questions?
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