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Stephen Holt MD-Nutraceuticals 2010

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    A REVOLUTION IN MEDICINE

    Questioning allopathic medicine

    Increased self-reliance of patients

    Portability of healthcare The pharmaceutical revolution

    DSHE Act, 1994

    Identifying the first line option

    Prevention vs. treatment

    Edutherapy

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    DIETARY SUPPLEMENTS

    Evidence-based

    Borrowed science Bioequivalence

    Pharmaceutical sciences Who owns the intervention?

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    PUBLIC HEALTH INITIATIVES

    The obesity pandemic

    Obesity-related disease

    The Metabolic Syndrome X Menopause management

    Osteoporosis

    Sleeplessness

    Digestive disorders

    Cancer prevention

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    THE OBESITY PANDEMIC

    Global

    Low carb diet craze

    Diabesity

    Obesity-related disease

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    DIABESITY

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    A LITANY OF DIETS

    ATKINS DIET

    ZONE DIET

    CARBOHYDRATE ADDICTS

    DIET

    SOUTH BEACH DIET SUGARBUSTERS DIET

    BEYOND ATKINS

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    ENHANCING LOW CARB DIETS

    Lifestyle change

    Exercise

    Behavior modification Rough calorie counting

    Dietary supplements that combat insulin

    resistance and components ofSyndrome X

    New diet revolution has health

    initiative

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    THE UNKNOWN EPIDEMIC

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    SYNDROME X PREVALENCE US

    ADULTS

    ATP 111, JAMA, Jan 16, 2002

    8814 Participants

    Data 1988-1994 with 2000 census data 47 million US residents with Syndrome

    X

    Forbes Magazine, August 6, 2001 70 million Americans with Syndrome X

    Children 2% prevalence ?

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    THE PUBLIC HEALTH RISK

    Syndrome X increases risk for :

    Maturity Onset DiabetesMellitus

    Cardiovascular Disease

    Cardiovascular Deaths

    Deaths from ALL CAUSESAm.J.Epidemiol, 148, 958, 1998.

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    INTEGRATED MEDICINE FOR

    SYNDROME X

    While proper management of the

    individual abnormalities of this

    syndrome can reduce morbidityand mortality, it seems unlikely that

    management of the individual

    abnormalities of this syndromeprovides better outcomes than a

    more integrated strategy, - CDC,

    Atlanta, Ga.

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    THE X FACTORS

    Insulin

    resistance

    Obesity High blood LDL

    Low blood HDL

    Slow clearance

    of fats from

    blood

    Cholesterol

    synthesis in the

    liver Blood clotting

    Adverse lifestyle

    Serum uric acid

    Homocysteine

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    GLUCOSE TOLERANCE WITH SOLUBLE FIBER

    THE PHYSIOLOGICAL BASIS OF THE GLYCEMIC

    INDEX

    Holt S, et al

    Effect of Gel

    Fiber

    Lancet,

    March 24th, 1979.

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    GLUCOSE TOLERANCE WITH SOLUBLE FIBER

    SLOW SUGAR ABSORBTION BY STOPPING

    STOMA

    CH EMPTYING

    Holt S, et al

    Effect of Gel

    Fiber

    Lancet,

    March 24th, 1979.

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    SUPER-SIZING AMERICA

    Americans exude

    complacency about

    their overweight status

    Obesity is part of ametabolic syndrome

    Syndrome X is under

    diagnosed and often

    mistreated by

    conventional medicine

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    SYNDROME X NUTRITIONAL FACTORS

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    SYNDROME X NUTRITIONAL FACTORS

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    MENOPAUSE MANAGEMENT

    47 million confused mature

    females

    Benefits of HRT outweighed byrisks

    Menopause does not fit disease

    model

    Nave notion of estrogen

    deficiency

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    HRT

    Cardiovascular risk

    Cancer promotion

    Cognitive decline

    Quality of life

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    EVIDENCE-BASED,

    COMBINATION SUPPLEMENT

    Black cohosh

    Soy isoflavones

    L-theanine Evening primrose oil

    Dong quai

    Chasteberry Gingko biloba

    Synergy: CombinationsReference:Annals of Internal Medicine,

    Vol. 137 No. 10, 2002

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    OSTEOPOROSIS

    Lifestyle

    Calcium is not enough

    Complex formulations for nutritionalsupport:

    calcium, soy isoflavones, ipriflavone,

    D3, zinc, copper, manganese, boron,

    antioxidants

    B6, B12, folic acid

    Action today for health tomorrow

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    SLEEP THE NATURAL WAY

    Lifestyle

    Hypnotic drugs are dangerous and

    addictive Nutritional support: Complex formulations

    Valerian, chamomile, passion flower, lemon

    balm, skullcap, hops, ashwagandha

    5 HTP, magnesium, melatonin, niacin, B6,

    folate

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    GI SUPPLEMENTS

    Pooping for health

    Enzymes

    Probiotics

    Prebiotics

    Detox

    Acid-related disorders

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    REAL ADVANCES IN GI

    Combining prebiosis,

    probiosis, detox with enzymes

    Biphasic neutralization or

    inhibition of acid secretion:

    natural acid neutralization,natural proton-pump inhibition

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    ZANASEC

    Patented, natural neutralization

    with fava bean flour, calcium,

    magnesium Proton-pump inhibition: Murakami

    S, et al Inhibition of gastric H+, K +

    - ATPase Planta Med, 57(1991)

    A

    nti-H. pylori

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    CANCER PREVENTION

    Antioxidants

    Lipo-hydro access

    Redox balance

    Independent power

    Green tea

    Ellagic acid

    Resveratrol

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    CONCLUSION

    Lifestyle change, good nutrition and well-

    planned dietary supplements or functional

    foods are first line options for prevention

    and, at least, complementary management

    of disease

    Advances in nutraceutical medicine may

    have more to offer than the next me-toodrug


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