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Structure Based Drug Designing for Mycoplasmal Pneumonia

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Page 1: Structure Based Drug Designing for Mycoplasmal Pneumonia

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U]XSE]SXC H@UCM MXSNMCUINLILN ODX BYEDZG@UB@G

ZLCSBDLI@

HF@_Y@ ASB@X UILNF 

:>0=53=:0: 

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 @HDS] MIUC@UC 

Byedzg`ub`g zlcsbdli` iu ` edbbdl e`sucdo 

`epsixcm zlcsbdli` iudg`}cm il e`}}gc ~i}f

Il 0956' Xicb`ll mcuexihcm }fc oixu} e`ucu do 

Byedzg`ub`g zlcsbdli` il b`l

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E`sucu

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Hce`suc }fc dxn`liub e`l hc cexc}cm oxdb}fc xcuzix`}dxy }x`e} odx ucvcx`g ~ccau `o}cx

}fc `es}c iloce}idl' iudg`}idl do }fc dxn`liubb`y ld} ilmie`}c `es}c iloce}idl,

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]@XNC] ZXD]CIL 

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}f`} edmc odx zxd}cil ~fduc ucpsclec ~cxcnxc`}cx }f`l0:: `bild `eim il gcln}f ~cxcucgce}cm ds} `uusbiln }f`} zxd}cil gcuu }f`l 0::`bild `eim il gcln}f ~c slgiacgy }d xczxcucl}

cuucl}i`g zxd}cil ~cxc cgibil`}cm suiln EM"FI] usi}c }d imcl}ioy }fc mszgie`}cu zxd}cilu ~i}fil}fc zxd}cdbc do Byedzg`ub`g zlcsbdli`

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BDMCGGILN DO ]@XNC] ZXD]CIL 

0, ]cbzg`}c `lm ]`xnc} Ucgce}idl

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IMCL]IOIE@]IDL DO uibig`x ZXD]CIL 

U]XSE]SXC  ]fc H`uie Gde`g @ginlbcl} Uc`xef ]ddg &HG@U]) oilmu xcnidlu do gde`g

uibig`xi}y hc}~ccl ucpsclecu, ]fc zxdnx`b edbz`xcu lsegcd}imc dxzxd}cil ucpsclecu }d ucpsclec m`}`h`ucu `lm e`gesg`}cu }fcu}`}iu}ie`g uinlioie`lec do b`}efcu, HG@U] e`l hc sucm }d ilocxosle}idl`g `lm cvdgs}idl`xy xcg`}idlufizu hc}~ccl ucpsclecu `u

~cgg `u fcgz imcl}ioy bcbhcxu do nclc o`bigicu, ]fc odggd~iln Hg`u} fi}u ~cxc xc}xicvcm ~fcl Hg`u}Z ~`u xsl `n`ilu}

zmh m`}`h`uc suiln Z>35=: zxd}cil `u }fc pscxy, ]fc }cbzg`}cf`viln ZMH"IM 0N@IT@ &88# imcl}i}y ~i}f }fc }`xnc} ucpsclec) f`uhccl ucgce}cm dl }fc h`uiu do b` uibig`xi}y ~i}f }fc }`xnc}xcpsixcm odx nclcx`}idl do }fc bdmcg

]fiu zxdnx`b nivcl ` zxd}cil pscxy xc}sxlu }fc bdu} uibig`x zxd}cilucpsclecu oxdb }fc zxd}cil m`}`h`uc }f`} }fc sucx uzceioy, Fcxc'Hg`u}Z zxdnx̀ b f`u hccl sucm }d xc}xicvc }fc bdu} uibig`x}cbzg`}cu do }fc }`xnc} zxd}cil suiln zxd}cil M`}` H`la zxd}cilu&zmh) m`}`h`uc

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UCGCE]IDL DO FDBDGDNDSU

UCPSCLEC 

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]fxcc ZMH ucpsclecu ufd~ vcxy uinlioie`l} uibig`xi}icu }d }fc }`xnc}ucpsclec ~i}f c"v`gscu cps`g }d ?,:'9,:'9,:'9,:xcuzce}ivcgy ) `lm`xc }fsu zd}cl}i`g }cbzg`}cu, 0N@IT@ iu ucgce}cm hce`suc do i}uhc}}cx exyu}`ggdnx`zfie xcudgs}idl &0,>:Ã) `lm finfcx dvcx`ggucpsclec imcl}i}y }d }fc }`xnc} ucpsclec &58#) `eedxmiln }dbdmcgcx, @gud i} ufd~u fdbdgdny ~i}f }fc }`xnc} ucpsclec,

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Bdmcg Nclcx`}idlBDMCGGCX

Odx fdbdgdny dx edbz`x`}ivc bdmcgiln do zxd}cil }fxcc"mibcluidl`g u}xse}sxcu ` }ddg$udo}~`xc l`bcm BDMCGGCXiu sucm fcxc,I} iu sucm }d hsigm }fc edbzgc}c 5M bdmcg do `l slald~l

zxd}cil u}xse}sxc do B,zlcsbdli` Zxd}cil BYE

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NCLCX@]CM BDMCG

zxd8,H9999:::0,zmh

zxd8,H9999:::8,zmh

zxd8,H9999:::5,zmhzxd8,H9999:::=,zmh

zxd8,H9999:::3,zmh

Ds} do 3 nclcx`}cm bdmcg I efduc dl ~i}f bilclcxny i,c, zxd8,H9999:::=,zmh "85?8=,69836

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zxd8,H9999:::0,zmh zxd8,H9999:::8,zmh zxd8,H9999:::5,zmh

zxd8,H9999:::=,zmh

zxd8,H9999:::3,zmh

Ds} do 3 nclcx }̀cm bdmcg I efduc dl ~i}f bil clcxny i,c, zxd8,H9999:::=,zmh "85?8=,69836

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Bdmcg Dz}ibi{`}idl suiln UZM_ 

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`ggd~cm xcnidl `lm edlu}`l}gy efceailn }fcxcusg}u }fxdsnf X`b`ef`lmx` zgd} `lm u`vcuucxvcx, Hcgd~ iu }fc X`b`ef`lmx` zgd} do dlc do }fc nclcx`}cm bdmcg ~i}f bil mdzc uedxc ~fief

iu ld} bdmcgcm ufd~iln udbc do xcuimsc ilmiu`ggd~cm xcnidl dl ~fief gddz bdmcgiln iuzcxodxbcm

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Zgd} do, Zxd8,H9999:::=,zmh ~i}f mdzc uedxc &"85?8=,69836) ~fief iu ld} bdmcgcm

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]fc xcusg}`l} bdmcg ~`u ufd~iln 6=,># xcuimsc il edxc xcnidl `lm :# il miu`ggd~cm xcnidlfclec i} iu o`ixgy nddm bdmcg,

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Gin`lm Ucgce}idl

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dlc dx bdxc fymxdncl `}dbu), Ld} bdxc }f`l 0: fymxdncl hdlm `eecz}dxu &li}xdncl dx dyncl `}dbu), @ bdgcesg`x ~cinf} slmcx 3:: n$bdg @ z`x}i}idl edcooieicl} gdn Z gcuu }f`l 3,

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Gin`lm Zxcz`x`}idl suiln EFCBUA]CEF }ddg

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}fcl gin`lm `lm }`xnc} hd}f ufdsgm hc il &ZMH) odxb`},

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MDEAILN

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Mdeailn `gndxi}fbu `xc `hgc }d nclcx`}c ` g`xnc lsbhcx do zduuihgcu}xse}sxcu

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@s}dMdea=@s}d Mdea iu ` usi}c do `s}db`}cm mdeailn }ddgu, I} iu mcuinlcm }d zxcmie}

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mdeailn `gndxi}fb iu GN@ &G`b`xeai`l Nclc}ie@gndxi}fb),

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MDEAILN XCUSG]U

Gin`lmu ]̀ hgc

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@ hcu} bdmcgcm 5M u}xse}sxc do zxd}cil ~`u mdeacm ~i}f }fc 0= gin`lmu, @bdln }fcucgin`lm n`vc }fc hcu} xcusg} ~i}f }fc bilibsb hilmiln clcxny "00,65 hs} ~`u ld}ucgce}cm `u zd}cl}i`g gin`lm hce`suc i} mdcu ld} odggd~ Giziluai xsgc do 3' fclec `ld}fcxgin`lm i,c, Gin`lm N@E Mi"fymxd @e`xhduc ~i}f hilmiln clcxny ">,6= ~`u ucgce}cm ds}

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]D]@G CLCXNY do  zxd}cil gin`lm edbzgcvHy suiln UZM_ }d}`g clcxny do zxd}cil gin`lm edbzgc ~`u e`gesg`}cm i,c, "05=?9,6?? C$a] sli}u

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