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EVALUATION OF TRADITIONAL PURIFICATION METHODS OF
KANDHAGAM
P. Rajalakshmi, K.L. Niraimathy, S. Moscow, M. Abeetha,
G.Victor Rajamanickam,
CARISM,SASTRA
Kandhagam (sulphur)Sulphur is an abundant, multivalent non-metal. Sulfur, in its native
form, is a yellow crystalline solid.
Classification of KandhagamGeneral Classification• Pirappu Kandagam• Kozhitalai Kandagam• VanaKenthi vaipu• Vaipu Kandagam
Based on Colour• White Kandagam – it cures all diseases• Parrot nose red Kandagam – used for calcinating 9 types of metals• Gold coloured (or) Gooseberry Kandagam – commonly used for
medicine• Black Kandagam – Rare type, Rejuvenator
Significance of Sulphur in Siddha
• It increases bile secretion, Laxative, Alterative, Antimicrobial, generally excreted by duct glands.
• It is used for curing Leucoderma, Hepatomegaly, Ascites, Peptic Ulcer, Eye disease, Cysts, Chronic venereal diseases and skin diseases.
• It is a potent drug used for the preparation of Rasayanam, Pills, Mezhugu and Bhasmas and Chenduram.
Sulphur toxicitySulphur is not an higlhy toxic substance. Improperly purified and irregularly prepared Sulphur medicine if consumed over a long period then it causes toxic effects.
The toxic feautures are– Yellowish discolouration of conjuctiva– Pallor of the face– Discolouration of the skin similar to the colour of ridged gourd flower– Disfigured and blackish teeth– Profuse hyperhidrosis with yellowish colour– Urine appears like goat’s urine– Faeces is dark yellow coloured– Bad breath (halitosis)– Dyspepsia– Flatulence– Distended abdomen with pain– Macules
Need for purification of Kandagam
• Detoxification implies removing the impurities inhibiting the potency of the medicine.
• Impurities of Kandagam should be removed with the detoxifying agent provided in Siddha literature.
• Four detoxifying agents are used for purification of Kandagam
• They are Milk, Henna, Banana stem, Peels of Tamarind fruit.
Process of Sulphur Purification
Melting of Butter Melting of Sulphur in Butter
Molten Sulphur poured into milk
Solidified sulphur in milk
This process is repeated for 30 times and the sample is analysed at initial, interim and final stages.
Chemical investigations
• Detoxified substance- Kandagam• Detoxifying agent – Milk
Parameters investigated• Estimation of Sulphur• Estimation of Calcium• Estimation of Phosphorous• Estimation of Lead• Estimation of Mercury
Investigated chemical parameters I SULPHUR II SULPHUR III SULPHUR I MILK II MILK III MILK
Sulphur % 39.132 46.02011 86.5871 1.860034 3.89373 4.213638
Calcium 140 140 120 160 140 100
Phosphorous 0.14535 0.18282 0.22601 0.14456 0.194306 0.23834
Mercury 0.082 0.00864 0.00942 0.00842 0.00662 0.00581
Lead 0.1157 0.3912 0.4235 0.4209 0.5741 0.3378
0
1
2
3
4
5
% O
F S
UL
PH
UR
I MILK II MILK III MILK
% OF SULPHUR IN MILK
0
20
40
60
80
100
Sul
phur
(%)
I SULPHUR II SULPHUR III SULPHUR
Percentage of Sulphur
110
115
120
125
130
135
140
CO
NC
EN
TR
AT
ION
IN
p
pm
I SULPHUR II SULPHUR III SULPHUR
LEVELS OF CALCIUM IN KANDAGAM
0
50
100
150
200
CO
NC
EN
TR
AT
ION
IN
p
pm
I MILK II MILK III MILK
LEVELS OF CALCIUM IN MILK
Calcium is a reducing agent, used for reducing metalsIt is also employed as a chelating agent (Calcium-EDTA)
0
0.05
0.1
0.15
0.2
0.25
% O
F P
HO
SP
HO
RO
US
I SULPHUR II SULPHUR III SULPHUR
LEVELS OF PHOSPHOROUS- KANDAGAM
0
0.05
0.1
0.15
0.2
0.25
% in
Pho
spho
rous
I MILK II MILK III MILK
LEVELS OF PHOSPHOROUS IN MILK
Phosphorous, a mineral, helps build strong bones and teeth.
Phosphorous is also involved in the release of energy from fat, protein, and carbohydrates during metabolism, and in the formation of genetic material, cell membranes, and many enzymes.
RDA - 800 milligrams for women and men 25 to 50 years
0
0.02
0.04
0.06
0.08
0.1
CO
NC
EN
TRA
TIO
N IN
pp
m
I SULPHUR II SULPHUR III SULPHUR
LEVELS OF MERCURY IN KANDAGAM
0
0.002
0.004
0.006
0.008
0.01C
ON
CE
NT
RA
TIO
N I
N
pp
m
I MILK II MILK III MILK
LEVELS OF MERCURY IN MILK
•The Food and Drug Administration (FDA) has set a maximum permissible level of 1 part of methyl mercury in a million parts (1 ppm).•Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus.
0.11
570.
3912
0.42
35
0
0.1
0.2
0.3
0.4
0.5
CO
NC
EN
TR
AT
ION
IN
p
pm
I SULPHUR II SULPHUR III SULPHUR
LEVELS OF LEAD IN KANDAGAM
0.42
09
0.57
41
0.33
78
0
0.1
0.2
0.3
0.4
0.5
0.6
CO
NC
EN
TR
AT
ION
IN
p
pm
I MILK II MILK III MILK
LEVELS OF LEAD IN MILK
Lead in dietary allowances.• Lead perturbs multiple enzyme systems. As in most heavy metals, any ligand with sulfhydryl groups is vulnerable. Perhaps the best-known effect is that on the production of heme.
• The FDA has set a maximum permissible level of 10 parts per million of
Need for Detoxification• Sulfur is present in all proteins, which makes it universally
available throughout the body for binding with mercury.
• Mercury has a particularly high affinity for thiol groups sulphur> amides> amines>carbon> phosphate.
Mercury-induced intracellular calcium modulated reactive oxygen species (ROS)
Cell apoptosis and necrosis Calcium antagonists abolished ROS production. (Kim et al.,2004 )
Calcium and lead are absorbed at the same site in the intestine (vitamin D receptor (VDR) gene )
It prefers calcium.
The ingested lead passes though the gastrointestinal tract and is excreted if there is also calcium present to prevent lead absorbtion.
As more calcium is consumed, less lead is able to get into the bloodstream.
The Centre for Disease Control guidelines for prevention of childhood lead poisoning recommends adequate dietary calcium and iron as measures to prevent lead toxicity
Uses of Sulphur – Siddha Literature
It is used for curing Leucoderma, Hepatomegaly, Ascites, Peptic Ulcer, Eye disease, Cysts, Chronic venereal diseases and skin diseases.
Uses of Lead – Siddha LiteratureIt is used for curing Leucoderma, Ascites, Peptic Ulcer, Eye disease, Chronic venereal diseases and skin diseases.
Uses of Mercury– Siddha LiteratureIt is used for curing Leucoderma, Peptic Ulcer, Eye disease, Chronic venereal diseases.
Conclusion
The Detoxification of Sulphur by traditional method involves removing of toxic substances both in the medicine and also safeguarding the body from heavy metal toxicity during the course of administration of the drug.
The nutritive value of the detoxifying agent-Milk also serves as a supplement for Balanced diet
ReferencesThyagara Mudaliyar,GunapadamThaathu Jeeva vaguppu, IIIrd Edn, Indian Medical Association, 1981.
P. Jeyaraj, Siddha Toxicology, Ist Ed. Department of Indian System of Medicine and Homeopathy, 1999.
Kuppusamy Mudaliyar, Siddha Vaithiya thiratu.
Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato S, Bindels RJ, Colle D Carmeliet P, Bouillon R, Carmeliet G Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13324-9.
Sang Hyun Kim and Raghubir P. Sharma Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling Toxicology and Applied Pharmacology Volume 196, Issue 1, 1 April 2004, 47-57.
Title 21—Food and Drugs Chapter I—Food and Drug Administration Department of Health and Human Services Subchapter D—Drugs for Human Use Code of federal regulations. United States Food and Drug Administration. Retrieved on 1 May 2007.
Preventing Lead Exposure in Young Children: A Housing-Based Approach to Primary Prevention of Lead Poisoning (2004) – Recommendations from the Advisory Committee on Childhood Lead Poisoning Prevention, 2004.