Date post: | 18-Dec-2014 |
Category: |
Health & Medicine |
Upload: | tariq-abdulla |
View: | 270 times |
Download: | 0 times |
Progress on Measurement in
Biology & Medicine:
Multiscale Systems Engineering
Ron Summers
Dept Electronic & Electrical Engineering, Loughborough University, UK
http://www-staff.lboro.ac.uk/~lsrs1
Outline
• Introduction to the Team
• Multiscale Modelling
Anatomic Level of Analysis
Cellular Level of Analysis
Protein Level of Analysis
Genome Level of Analysis
• Future Work
International Team
Multiscale Modelling
Context
Engineering Dimension
“…multiscale modelling is the field of solving
physical problems which have important
features at multiple scales, particularly
multiple spatial and (or) temporal scales”.
Wikipedia, accessed 2010
Scales of Measurement
Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9
Medical Dimension
• Why is it important to better understand
congenital heart defects ?
• What is the Tetralogy of Fallot from an
anatomical standpoint ?
• Which embryological processes are
involved in the formation of the Tetralogy
of Fallot ?
Why is it important to know more about the congenital
heart defect and particularly about the Tetralogy of Fallot ?
The prevalence of congenital heart defects,
the most common congenital anomaly
observed in newborns, has been reported to
be 5-10 per 1000 births
10% of the childhood mortality
Tetralogy of Fallot is the most common form
of cyanotic congenital heart disease.
It affects 9%-15% of all infants and children
with congenital heart disease (CHD) which
represents 55%-70% of all cyanotic
congenital malformations
We need to improve our knowledge about
this abnormality
Multiscale Modelling
Anatomic Level
Aorta
Pulmonary artery
Right
Ventricle
Anterior view Posterior view
Anatomy of the Normal Human Heart
Tetralogy of Fallot
Pulmonary Stenosis
Ventricular Septal Defect by
malalignment
Dextroposition of the Aorta
(aortic overriding)
Right ventricular hypertrophy
desaturation
Muscular
Septum
Membranous
Septum
Nature
Normal Anatomic Development
Multiscale Modelling
Cellular Level
Scales of Measurement
Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9
Epithelial to Mesenchymal Transition
Notch Delta
EMT Simulations
In vitro EMT
Wildtype Notch1 BMP2
L. Luna-zurita et al. “Integration of a Notch-dependent mesenchymal gene
program and Bmp2-driven cell invasiveness regulates murine cardiac
valve formation,” The Journal of Clinical Investigation, vol. 120, 2010.
Multiscale Modelling
Protein Level
Multiscale Modelling
Genome Level
Which embryological processes are involved
in the formation of the Tetralogy of Fallot ?
Scale of tissue and cells
Which embryological processes are involved in the
formation of the Tetralogy of Fallot ? Scale of gene regulation
Future Work
A lot of work remains…
• Information Issues • Scale-linking
• Biological Networks
• Methodological Issues • Multiscale Model Process
• Multiscale Model Validation
• Multiscale Visualization
• Software Issues • Multiscale Software Programming
• Patho-physiological Issues • Anatomic Definition of Tetralogy of Fallot
Thank you for your
attention
Optical Physiological Tomography: Concepts
Comprises biomedical photonics, microelectronics engineering, systems engineering, applied signal and image processing, and multiscale modelling/simulation
Fast Fast
digital digital
CameraCamera
USBUSB
MicroMicro--
electronicselectronics
Oxyg
en
level
O2%
Oxyg
en
level
H i g h
Low
Frequency
6 – 9 HzW
avelength
(400 –900nm
)
MultiMulti--
wavelengthwavelength
illuminatorilluminator
Electronic sub system
Photonics sub system
Biophotonics Imaging System