Sunday, October 1411:30 Registration and poster mounting13:00 Welcome: Otmar D. Wiestler 13:15 Welcome lecTURe Elaine Fuchs
Skin stem cells in homeostasis and cancer
Session 1 Leukemic STem ceLLS AND micro- eNviroNmeNT
Chair: Andreas Trumpp
14:15 Tariq Enver Genetic and epigenetic sources of hetero-geneity in childhood leukaemia
14:45 Shahin Rafii Angiocrine factors-derived from tumor-
specified vascular niche induce and maintain tumor initiating cells
15:15 Coffee break 15:45 Markus Müschen
oncogene signaling and negative feedback in leukemia
16:15 Catriona Jamieson malignant progenitor reprogramming:
Biologic and therapeutic implications16:45 Paul Frenette
Neural regulation of stem cell and cancer cell migration
17:15 David Lyden Tumor-derived exosomes educate bone
marrow progenitor cells to a pro-metastatic phenotype
17:45 Welcome reception
Monday, October 1509:00 Greeting address Philipp U. Heitz German Academy of Sciences leopoldina
Session 2 STem ceLLS oF SoLiD TumorS AND meTASTASiS
Chair: Varda Rotter
09:15 Thomas BrabletzemT, microRNAs and cancer stem cells
09:45 Michael Clarke Deregulation of stem cell self-renewal pathways in cancer
10:15 Coffee break 10:45 Andreas Trumpp circulating metastasis-initiating cells in
breast cancer 11:15 Thea Tlsty
cellular conversations that control malignancy
11:45 Luis Parada Genetic mouse models of glioma: Trans-
lational tools for therapeutic development
12:15 Lunch break 13:15 Gregory Driessens (short talk)
Defining the mode of tumor growth by clonal analysis
13:30 Beatriz Aranda-Orgilles (short talk)Regulation of stem cell self-renewal, differentiation and transformation by the ubiquitin-proteasome system
13:45 Michael Shen Stem cells and the origin of prostate cancer14:15 Owen Witte
Stem cells in prostate cancer initiation and progression
14:45 PoSTeR SeSSioN
16:30 KeYNoTe lecTURe Philip Beachy
Sonic hedgehog-expressing basal stem cells are the cell-of-origin for bladder cancer
17:30 Meet-the-speakers dinner, DKFZ
Tuesday, October 16
Session 3 BrAiN Tumor STem ceLLS
Chair: Michael Platten 09:00 Jürgen Knoblich Using Drosophila as a model system for
tumorigenesis and cancer stem cells09:30 Ana Martin-Villalba
The role of cD95 in tumor initiation and tumor progression
10:00 Hai-Kun Liu (short talk)Genetic dissection of self-renewal and differentiation in normal and malignant brain stem cells
10:15 Coffee break
10:45 KeYNoTe lecTURe Ronald McKay Stem cell technologies & human functional
genomics
11:45 PoSTeR AWARD
12:00 Lunch break
Session 4 reProGrAmmiNG AND STem ceLL PATHWAYS
Chair: Anthony Ho
13:15 Marius WernigUpdates on induced neuronal cell reprogramming
13:45 Jochen Utikal (short talk)induced pluripotency and cancer cells
14:00 Varda RotterThe role of p53 in the life of stem cells
14:30 Coffee break 15:00 Mariano Barbacid
cancer initiating cells in non-small-cell lung carcinoma
15:30 Joachim Wittbrodtexclusive multipotency in post-embryonic neural stem cells of the fish retina
16:00 KeYNoTe lecTURe Hans Clevers Wnt signaling, lgr5 stem cells and cancer
17:00 Farewell reception
Venue
German cancer Research centercommunication centerim Neuenheimer Feld 280D-69120 Heidelberg, Germanyphone: +49 (0) 6221 42-0www.dkfz.de/Scc2012
Conference office
Dagmar JarekRenate KimGerman cancer Research centerim Neuenheimer Feld 280D-69120 Heidelberg, Germanyphone: +49 (0) 6221 42-2841fax: +49 (0) 6221 42-2840e-mail: [email protected]
Sponsored by
Heinrich F. C. Behr-Stiftung, Heidelberg
Speakers
mariano Barbacid, madridPhilip Beachy, StanfordThomas Brabletz, Freiburg michael F. clarke, StanfordHans c. clevers, UtrechtTariq enver, londonPaul S. Frenette, New Yorkelaine Fuchs, New Yorkcatriona Jamieson, San DiegoJürgen A. Knoblich, ViennaHai-Kun liu, HeidelbergDavid c. lyden, New YorkAna martin-Villalba, HeidelbergRonald mcKay, Baltimoremarkus müschen, San Franciscoluis F. Parada, DallasShahin Rafii, New YorkVarda Rotter, Rehovotmichael m. Shen, New YorkThea Tlsty, San FranciscoAndreas Trumpp, HeidelbergJochen Utikal, Heidelbergmarius Wernig, StanfordJoachim Wittbrodt, Heidelbergowen Witte, los Angeles
organizers
Joe B. Harford, BethesdaRon mcKay, BaltimoreAndreas Trumpp, Heidelbergotmar D. Wiestler, Heidelberg
Fron
t cov
er: J
ürge
n A.
Kno
blic
h, V
ienn
a 7th International Heinrich F. C. Behr-Symposiumoctober 14 – 16, 2012German cancer research center (DkFZ), Heidelberg
STem ceLLS AND cANcer
2012
DKFZ main building
Main entrance
Communication Center
from B37 / A656 / Main station