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Supplementary Fig.1
0.02.04.06.08.0
10.012.014.0
DAOY D458Med
Med8A NCB
miR-182
miR-183
Native expression
Re
lativ
e e
xpre
ssio
nra
tio v
s. H
KsR
NA
sa
0
10
20
30
40
50
60
70
pCMX 182K1 182K2 183K1 183K2
Re
lativ
e e
xpre
ssio
nra
tio v
s. p
CM
X
DA
OY
Med
8AR
ela
tive
exp
ress
ion
ratio
vs.
pC
MX
Stable overexpression
b
0
20
40
60
80
100
120
140
pCMX 182K1 182K2 183K1 183K2
D45
8 M
ed
Re
lativ
e e
xpre
ssio
nra
tio v
s. p
CM
X
012345678
pCMX 182K1 182K2 183K1 183K2
Supplementary Fig.1
0.0
0.3
0.6
0.9
1.2
1.5
siCtrl si182 siCtrl si183
Re
lativ
e e
xpre
ssio
nra
tio v
s. s
iCtr
lR
ela
tive
exp
ress
ion
ratio
vs.
siC
trl
Transient knockdown
DA
OY
Med
8Ac
0.00.20.40.60.81.01.21.41.6
siCtrl si182 siCtrl si183
Re
lativ
e e
xpre
ssio
nra
tio v
s. s
iCtr
l
D45
8 M
ed
0.0
0.3
0.6
0.9
1.2
1.5
siCtrl si182 siCtrl si183
Supplementary Fig.2
Supplementary Fig.3
Molecular subgroup
miR-182 miR-183 miR-96
Supplementary Fig.4
Supplementary Fig. 5
Transient knockdown
0.5
1.0
1.5
2.0
2.5
3.0
3.5
1 2 3 4 5 6 7
DAOY-siCtrlDAOY-si183
DAOY-si182
0.5
1.0
1.5
2.0
2.5
3.0
1 2 3 4 5 6 7
M8A-siCtrl
M8A-si183
M8A-si182
Day
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
0.0
1.0
2.0
3.04.0
5.0
6.0
7.0
8.0
1 2 3 4 5 6 7
DAOY-pCMX
DAOY-183K1
DAOY-183K2
0.0
1.0
2.0
3.04.0
5.0
6.0
7.0
8.0
1 2 3 4 5 6 7
DAOY-pCMX
DAOY-182K1
DAOY-182K2
0.51.01.52.02.53.03.54.04.55.0
1 2 3 4 5 6 7
M8A-pCMXM8A-183K1M8A-183K2
0.51.01.52.02.53.03.54.04.55.0
1 2 3 4 5 6 7
M8A-pCMXM8A-182K1
M8A-182K2
Stable overexpression
Day Day
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
Me
tab
olic
act
ivity
, ra
tio v
s. D
ay1
DA
OY
Med
8A
*
*
**
Supplementary Fig. 6