0
0.02
0.04
0.06
0.08
12h
0
12h
TZPD24
h 0
24h
TZPD48
h 0
48h
TZPD
Supplementary Figure 1
IRF-1E
xpre
ssio
n re
lativ
e to
GA
PD
H
0
0.02
0.04
0.06
0
0.02
0.04
0.06
0.08
NHU1
NHU2
NHU3
FOXA1
Supplementary Figure 1
0
0.1
0.2
0.3
0.4
0.5
12h
0
12h
TZPD24
h 0
24h
TZPD48
h 0
48h
TZPD
0
0.1
0.2
0.3
0.4
0.5
10h
0
10h
TZ
10h
PD
10h
TZPD24
h 0
24h
TZ
24h
PD
24h
TZPD48
h 0
48h
TZ
48h
PD
48h
TZPD
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
10h
0
10h
TZ
10h
PD
10h
TZPD24
h 0
24h
TZ
24h
PD
24h
TZPD48
h 0
48h
TZ
48h
PD
48h
TZPD
NHU1
NHU2
NHU3
Exp
ress
ion
rela
tive
to G
AP
DH
Supplementary Figure 1
c-JunE
xpre
ssio
n re
lativ
e to
GA
PD
H (
x10-2
)
0
0.04
0.08
0.12
0.16
0
2
4
6
8
10
12
0
0.04
0.08
0.12
0.16
12h 0 12hTZPD
24h 0 24hTZPD
48h 0 48hTZPD
NHU1
NHU2
NHU3
Supplementary Figure 2
B
untreateduntreated
TZ+PD153035+200 nM siRNATZ+PD153035+200 nM siRNA200 nM siRNA200 nM siRNA
TZ+PD153035TZ+PD153035
A