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Supplementary Information S I J. Braz. Chem. Soc., Vol. 25, No. 6, S1-S15, 2014. Printed in Brazil - ©2014 Sociedade Brasileira de Química 0103 - 5053 $6.00+0.00 *e-mail: [email protected] Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine Sulfonyl Piperazine Derivatives Nadigar R. Mohan, a Swamy Sreenivasa,* ,a Karikere E. Manojkumar, a Tadimety M. C. Rao, b Boreddy S. Thippeswamy c and Parameshwar A. Suchetan a a Department of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India b Tadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur 572 168, Karnataka, India c Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur 572 102, Karnataka, India Figure S1. 1 H NMR spectrum (CDCl 3 , 399.6 MHz) of compound 3.
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Page 1: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Supplementary Information SIJ. Braz. Chem. Soc., Vol. 25, No. 6, S1-S15, 2014.

Printed in Brazil - ©2014 Sociedade Brasileira de Química0103 - 5053 $6.00+0.00

*e-mail: [email protected]

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine Sulfonyl Piperazine Derivatives

Nadigar R. Mohan,a Swamy Sreenivasa,*,a Karikere E. Manojkumar,a Tadimety M. C. Rao,b Boreddy S. Thippeswamyc and Parameshwar A. Suchetana

aDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India

bTadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur 572 168, Karnataka, India

cDepartment of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur 572 102, Karnataka, India

Figure S1. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 3.

Page 2: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S2

Figure S2. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 5.

Figure S3. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 6.

Page 3: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S3Vol. 25, No. 6, 2014

Figure S4. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 8.

Figure S5. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 9.

Page 4: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S4

Figure S6. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 11c.

Figure S7. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 11f.

Page 5: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S5Vol. 25, No. 6, 2014

Figure S8. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 11g.

Figure S9. 1H NMR spectrum (CDCl3, 399.6 MHz) of compound 11i.

Page 6: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S6

Figure S10. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 3.

Figure S11. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 5.

Page 7: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S7Vol. 25, No. 6, 2014

Figure S12. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 9.

Figure S13. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 11c.

Page 8: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S8

Figure S14. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 11f.

Figure S15. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 11g.

Page 9: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S9Vol. 25, No. 6, 2014

Figure S16. 13C NMR spectrum (CDCl3, 100.4 MHz) of compound 11i.

Figure S17. IR spectrum (KBr) of compound 3.

Page 10: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S10

Figure S18. IR spectrum (KBr) of compound 5.

Figure S19. IR spectrum (KBr) of compound 9.

Page 11: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S11Vol. 25, No. 6, 2014

Figure S20. IR spectrum (KBr) of compound 11c.

Figure S21. IR spectrum (KBr) of compound 11f.

Page 12: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S12

Figure S22. IR spectrum (KBr) of compound 11g.

Figure S23. IR spectrum (KBr) of compound 11i.

Page 13: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S13Vol. 25, No. 6, 2014

Figure S24. CHNS analysis of compound 11a. Figure S26. CHNS analysis of compound 11c.

Figure S25. CHNS analysis of compound 11b. Figure S27. CHNS analysis of compound 11d.

Page 14: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine J. Braz. Chem. Soc.S14

Figure S28. CHNS analysis of compound 11e. Figure S30. CHNS analysis of compound 11g.

Figure S29. CHNS analysis of compound 11f. Figure S31. CHNS analysis of compound 11h.

Page 15: Supplementary Information J. Braz. Chem. Soc. SIaDepartment of Studies and Research in Chemistry, Tumkur University, Tumkur 572 103, Karnataka, India bTadimety Aromatics Pvt. Ltd,

Mohan et al. S15Vol. 25, No. 6, 2014

Figure S32. CHNS analysis of compound 11i. Figure S33. CHNS analysis of compound 11j.


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