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Horizon 2020Innovation Action: BIOTEC-3-2014

Widening Industrial Application of Enzymatic Processes

Sustainable industrial processesbased on a C–C bond-forming

enzyme platform

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Horizon 2020 BIOTECH-3-2014INNOVATION  ACTION

CARBAZYMES GA 635595

Total Consortium Budget 9.2 M €

EU Maximum Grant Amount 8.2 M €

SME Funding (ca. 30%) 2.5 M €

Creation of New Jobs 14 ER, 6 ESR

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5 COUNTRIES

UK Spain Croatia Germany The Netherlands

6 SME´s 7 academic partners 1 large company

CARBAZYMES at a Glance

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Carboligation is of central importance in industrialsynthesis to create relevant new molecules

Implementation of biocatalytic carboligationprocesses remains largely unexplored due to: long development timelines lack of broader biocatalytic reaction platforms

CarbaZymes targets the “Valley of Death”with industry-suited carboligation enzymes for biocatalytic synthesis of industrial products

APIs (e.g. anti-cholesterol/-diabetes; >28 Mrd/yr market) bulk chemicals (polymer precursors)

CARBAZYMES Platform

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Aldolase 4-­‐OT Th-­‐DP

Transaminases

Scaff

old  by

C-­‐C  coup

ling

Op=

onal  

Mod

ifica=o

ns

Fine

 che

micals/APIs

Oxidoreductases Dehydratases Chemical

Deoxysugars

Chiral  building  blocks

Specialty  aminoacids

HHDH

Bulk  che

micals

Hydroxy  acids

Branchedacids

ω-­‐Amino  acidsCatalyst  Too

lbox

Enzyme  panels

Algorithms

Specific  enzymes

BROAD  RANGE  CARBOLIGATION  PLATFORM  DEM

O/M

ARK

ET

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Company Types in CARBAZYMES

Adapted from Festel Capital 2010OECD workshop "Outlook on Industrial Biotechnology”

high

DedicatedStart-ups

DedicatedSMEs

DedicatedMNEs

DiversifiedSMEs

DiversifiedMNEs

DedicatedMNEs

DiversifiedSMEs

DiversifiedMNEs

DedicatedSMEs

DedicatedStart-ups

Technology developmentCompany sizeC

omm

erci

al d

evel

opm

ent

Impo

rtan

ce o

f bio

tech

nolo

gy

low low

high

low highsmall large

Bridging the Gap between Lab and Industrial Scale

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15%15%

23%23%

36%36%

10%10%25% of overall PMs forbioprocess development,scale-up & demonstration

Work Packages & Schedule

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*Allowable cost contribution of : 0.01 €/kg

0.1€/kg

100€/kg

10 €/kg

1 €/kg

*Organic Process Research & Development 2011, 15, 266–274

The economic challenge

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CARBAZYMES products, procedures and servicesare expected to be commercialized in differentbusiness segments

Innovation, Exploitation, Impact

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Dissemination

General public

Academic community

Industry

Promoting societal awareness: Biocatalysis and biotechnology

as a sustainable tool for industrial syntheses

Help to bring CARBAZYMES products to market

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