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T and B Cell Costimulation

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T and B Cell Costimulation. Robert H. Carter, MD [email protected] Div. Rheumatology, Dept. Medicine Dept. Microbiology Program in Cellular and Molecular Biology Program in Immunology University of Alabama at Birmingham. Germinal Center, WT CD19, SRBC Day 7. Red pulp. FDC. Germinal - PowerPoint PPT Presentation

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T and B Cell Costimulation Robert H. Carter, MD [email protected] Div. Rheumatology, Dept. Medicine Dept. Microbiology Program in Cellular and Molecular Biology Program in Immunology

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T and B Cell CostimulationRobert H. Carter, [email protected]. Rheumatology, Dept. MedicineDept. MicrobiologyProgram in Cellular and Molecular BiologyProgram in ImmunologyUniversity of Alabama at Birmingham
PNA Alexa 488 GreenCD35 Alexa 350 BlueKi-67 Alexa 555 RedIgD Bio SA-Cy5 goldGerminal Center, WT CD19, SRBC Day 7 CentralarterioleGerminalCenterMarginal Sinus Endothelial cellFDCMarginal zoneRed pulp
Structure of a Folliclehypermutation affinity maturationclass switch
Antigen Binding and Processing

CD40MHCClass II mIgMB cell
Resting T Cell

T cellT CellReceptor
Partial T-B Collaboration-Anergy
Priming of T Cell-CD40L

CD28T cell
T-B Collaboration-CD80

CD40
PrimedB CellCD28T-B Collaboration-CTLA4CD80
Collaboration blocked? AnergyBlocking AgentsCD80CD28T cellCD40Lanti-CD40LCTLA4IgB cell

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