Table 1. Predicted Structures and functions of ... · Table 1. Predicted Structures and functions...

Table 1. Predicted Structures and functions of hypothetical proteins in Mycobacterium tuberculosis KZN

1435 through comparative genomic approach

EGG Gene ID CDD-Blast Interproscan Pfam COGs PS2 structure

mtb:TBMG_00004 NO NO Bacterial chaperone

lipoprotein

(PulS_OutS)

NO NO

mtb:TBMG_00007 DNA polymerase III

subunits gamma and

tau; Validated

NO NO NO 2pziA- 14- 38- 0.003

mtb:TBMG_00008 NO NO RUN domain; VirB8

protein

NO NO

mtb:TBMG_00012 NO NO NO NO 2f23A-14 -38- 0.002

mtb:TBMG_00019 FHA [cd00060],

Forkhead associated

domain (FHA); found

in eukaryotic and

prokaryotic proteins.

Forkhead-

associated (FHA)

domain;

SMAD/FHA

domain

FHA domain FHA-domain-

containing

proteins

2ff4A-23 -101-6e-23

mtb:TBMG_00020 FHA [cd00060],

Forkhead associated

domain (FHA); found

in eukaryotic and

prokaryotic proteins.

Forkhead-

associated (FHA)

domain; Annexin;

SMAD/FHA

domain

FHA domain NO 1y0fB-14- 45-3e-05

mtb:TBMG_00025 Biofilm regulator BssS;

BssS (also known as

YliH) regulates

Escherichia coli K-12

biofilm formation

through quorum

sensing. BssS is also

involved in motility

regulation as it

represses motility 7

fold by decreasing

transcription of the

flagella and motility

loci.

NO Roadblock/LC7

domain ; NOSIC

(NUC001) domain

NO NO


BssS (also known as

YliH) regulates


biofilm formation

through quorum

sensing.

NO NO NO 1qvrA- 24- 42-2e-04

mtb:TBMG_00027 Proteins of 100

residues with WXG;

ESAT-6 is a small

protein appears to be of

fundamental

importance in virulence

and protective

immunity in

Mycobacterium

tuberculosis.

ESX-1 secretion-

associated protein

EspC

Plant invertase/pectin

methylesterase

inhibitor ; KIF-1

binding protein C

terminal ; FlgN

protein

NO NO

http://www.genome.jp/dbget-bin/www_bget?mtb:TBMG_00004









mtb:TBMG_00035 DinB superfamily; The

DinB family are an

uncharacterised family

of potential enzymes;

Wyosine base

formation; Some

proteins in this family

appear to be important

in wyosine base

formation in a subset of

phenylalanine specific

tRNAs. ; TIGR03084

family protein; This

family, like Pfam

family pfam07398,

belongs to the larger set

of probable enzymes

modeled by

TIGRFAMs family

TIGR03083.

tRNA wybutosine-

synthesis;

Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate

isomerase N-terminal

domain ; Wyosine

base formation

NO 2nsfA-14-132-9e-32

mtb:TBMG_00036 H+ Antiporter protein; Major facilitator

superfamily;

general substrate

transporter

Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

2cfqA-12-48-7e-06

mtb:TBMG_00038 NO NO PRA1 family protein NO NO

mtb:TBMG_00039 Probable lipoprotein

LpqN; This family is

conserved in

Mycobacteriaceae and

is likely to be a

lipoprotein.

Lipoprotein LpqT,

predicted

Probable lipoprotein

LpqN

NO NO

mtb:TBMG_00046 Helix-turn-helix

domains; A large

family of mostly alpha-

helical protein domains

with a characteristic

fold

Transcription

regulator PadR N-

terminal; Winged

helix-turn-helix

transcription

repressor DNA-

binding

Transcriptional

regulator PadR-like

family

Predicted

transcriptional

regulators

1yg2A-21-116-2e-27

mtb:TBMG_00048 NO NO LITAF-like zinc

ribbon domain

NO NO

mtb:TBMG_00050 NO; This is a putative

transmembrane protein

from bacteria

Uncharacterised

conserved protein

UCP010361,

membrane

NO NO 2a65A-14-30-0.008

mtb:TBMG_00051 Type 1 glutamine

amidotransferase

(GATase1)-like domain

found in a subgroup of

proteins similar to PfpI

from Pyrococcus

furiosus;

ThiJ/PfpI Putative

amidotransferase

Putative

intracellular

protease/amidas

e

3bhnA-20-165-7e-42

mtb:TBMG_00059 Macro domain,

Poa1p_like family. The

macro domain is a

high-affinity ADP-

ribose binding module;

Appr-1-p

processing

Macro domain Uncharacterized

ACR related to

the C-terminal

domain of

histone

macroH2A1

2dx6A-22-138-1e-33










mtb:TBMG_00074 Superfamily of metallo-

dependent hydrolases

(also called

amidohydrolase

superfamily);

Imidazolonepropionase

and related

amidohydrolases

[Secondary metabolites

biosynthesis, transport,

and catabolism]

Amidohydrolase 1;

Metal-dependent

hydrolase,

composite domain

Amidohydrolase

family

Imidazolonepro

pionase and

related

amidohydrolases

2qs8A-27-303-3e-83

mtb:TBMG_00079 NO NO Nucleotidyl

transferase of

unknown function

(DUF1814) ;

Homoserine

dehydrogenase, NAD

binding domain

NO 2ewrA-10-50-3e-07

mtb:TBMG_00080 NO NO NO NO 1n3gA-8-48-2e-06

mtb:TBMG_00081 Pyridoxine 5'-

phosphate (PNP)

oxidase-like proteins;

The PNPOx-like

superfamily is

composed of

pyridoxine 5'-

phosphate (PNP)

oxidases and other

flavin mononucleotide

(FMN) binding

proteins, which

catalyze FMN-

mediated redox

reactions.

FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

related

Pyridoxamine 5'-

phosphate oxidase

NO 3cp3A-29-118-5e-28

mtb:TBMG_00089 Ligand-binding

SRPBCC domain of an

uncharacterized

subfamily of proteins;

Polyketide

cyclase/dehydrase;

START-like

domain

Polyketide cyclase /

dehydrase and lipid

transport

NO 1xuvA-13-62-1e-10

mtb:TBMG_00091 Predicted membrane

protein (DUF2127)

NO Predicted membrane

protein (DUF2127)

Uncharacterized

membrane

protein

NO

mtb:TBMG_00094 Anti-sigma-K factor

rskA

NO Putative zinc-finger NO 2q1zB-23-37-0.007

mtb:TBMG_00095 HNH nucleases; HNH

endonuclease signature

which is found in viral,

prokaryotic, and

eukaryotic proteins.

HNH nuclease HNH endonuclease NO 2qgpB-17-36-0.010

mtb:TBMG_00096 NO NO MIF4G domain NO NO

mtb:TBMG_00099 FcoT-like thioesterase

domain

Long-chain fatty

acyl-CoA

thioesterase,

Rv0098-like

FcoT-like thioesterase

domain

NO 2pfcA-97-282-3e-77

mtb:TBMG_00101 Phosphopantetheine

attachment site; A 4'-

phosphopantetheine

prosthetic group is

attached through a

serine.

Phosphopantetheine

-binding; Acyl

carrier protein-like

Phosphopantetheine

attachment site

NO 1n8lA-28-35-0.003

mtb:TBMG_00105 effector domain of the

CAP family of

transcription factors

Cyclic nucleotide-

binding domain;

RmlC-like jelly roll

fold; NAD(P)-

binding domain;

Cyclic nucleotide-

Cyclic nucleotide-

binding domain

cAMP-binding

domains -

Catabolite gene

activator and

regulatory

subunit of

no













binding-like cAMP-

dependent

protein kinases

mtb:TBMG_00107 Cobalamin synthesis

protein cobW C-

terminal domain;

Putative GTPases (G3E

family)

Cobalamin (vitamin

B12) biosynthesis

CobW-like; C-

terminal

CobW/HypB/UreG,

nucleotide-binding

domain ; Cobalamin

synthesis protein

cobW C-terminal

domain

Putative

GTPases (G3E

family)

1nijA-15-187-2e-48

mtb:TBMG_00111 Rhomboid family; This

family contains integral

membrane proteins that

are related to

Drosophila rhomboid

protein.

Peptidase S54,

rhomboid domain

Rhomboid family Uncharacterized

membrane

protein

(homolog of

Drosophila

rhomboid)

3b44A-20-109-7e-25

mtb:TBMG_00117 L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

Uncharacterized

BCR

1zatA-19-129-8e-31

mtb:TBMG_00124 NO CopG-like DNA-

binding

Ribbon-helix-helix

protein, copG family

NO 1e4fT-30-35-0.004

mtb:TBMG_00128 Uncharacterized

protein, probably

involved in trehalose

biosynthesis

[Carbohydrate transport

and metabolism]

Aminoglycoside

phosphotransferase

Phosphotransferase

enzyme family

Uncharacterized

protein,

probably

involved in

trehalose

biosynthesis

no

mtb:TBMG_00131 NodN (nodulation

factor N) contains a

single hot dog fold

similar to those of the

peroxisomal Hydratase-

Dehydrogenase-

Epimerase (HDE)

protein, and the fatty

acid synthase beta

subunit.

MaoC-like

dehydratase

MaoC like domain Predicted acyl

dehydratase

2c2iA-100-182-3e-47

mtb:TBMG_00139 Nuclear transport factor

2 (NTF2-like)

superfamily

NO SnoaL-like domain NO 1nwwB-16-60-3e-10

mtb:TBMG_00141 NO NO NO Uncharacterized

BCR

3djmB-32-149-3e-37

mtb:TBMG_00143 endonuclease III;

includes endonuclease

III (DNA-(apurinic or

apyrimidinic site)

lyase), alkylbase DNA

glycosidases (Alka-

family) and other DNA

glycosidases; 3-

methyladenine DNA

glycosylase/8-

oxoguanine DNA

glycosylase [DNA

replication,

recombination, and

repair]

DNA glycosylase NO 3-

Methyladenine

DNA

glycosylase

1mpgA-16-152-1e-37

mtb:TBMG_00146 NO Leucine carboxyl

methyltransferase

Leucine carboxyl

methyltransferase

NO 2uyoA-47 -45-5e-06

mtb:TBMG_00147 Leucine carboxyl

methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-72-214-3e-56












methyltransferase,

putative

mtb:TBMG_00151 NO NO NO NO 2b5uA-22-35-0.004

mtb:TBMG_00164 4-hydroxybenzoyl-CoA

thioesterase (4HBT).

Thioesterase

superfamily

Thioesterase

superfamily

Predicted

thioesteras

2o5uA 43 138 9e-34


SRPBCC domain of an

uncharacterized

subfamily of proteins

Streptomyces

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2d4rA-18-95-7e-21

mtb:TBMG_00168 NO NO Permease ABC-type

toluene export

system,

permease

component

NO

mtb:TBMG_00176 NO NO Staphylococcus

haemolytic protein

NO NO

mtb:TBMG_00177 RDD family; This

family of proteins

contain three highly

conserved amino acids:

one arginine and two

aspartates

RDD RDD family NO NO

mtb:TBMG_00181 YhgE/Pip N-terminal

domain; ABC-2 type

transporter

NO NO Predicted

membrane

protein

3cniA-14-49-2e-06

mtb:TBMG_00182 Cupin domain; Pirin-

related protein

Pirin, N-terminal;

Cupin, RmlC-type;


fold

Pirin Pirin-related

protein

1tq5A-35-256-3e-69

mtb:TBMG_00189 SPW repeat; A short

repeat found in a small

family of membrane-

bound proteins. This

repeat contains a

conserved SPW motif

in the first of two

transmembrane helices.

SPW repeat SPW repeat ; Poly-

beta-hydroxybutyrate

polymerase N terminal

NO NO

mtb:TBMG_00191 Transcriptional

regulators CsoR

(copper-sensitive

operon repressor),

RcnR, and FrmR, and

related domains

NO Metal-sensitive

transcriptional

repressor

Uncharacterized

BCR

2hh7A-38-85-3e-18

mtb:TBMG_00192 The Major Facilitator

Superfamily (MFS) is a

large and diverse group

of secondary

transporters that

includes uniporters,

symporters, and

antiporters.; Arabinose

efflux permease


and metabolism]

Major facilitator

superfamily

domain, general

substrate transporter

Major Facilitator

Superfamily

Arabinose efflux

permease

1pw4A-13-86-1e-17


catalytic domain

L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

Uncharacterized

BCR

1zatA-16-136-7e-33

mtb:TBMG_00194 NO NO NO NO 1f06A-15-31-0.010

mtb:TBMG_00201 NO NO ABC transporter

transmembrane region

NO 2b5uA-20-37-0.007















mtb:TBMG_00202 NO NO Myb/SANT-like

DNA-binding domain

; 6-O-methylguanine

DNA

methyltransferase,

DNA binding domain;

Helix-turn-helix

domain

NO NO

mtb:TBMG_00205 NO Lysylphosphatidylg

lycerol synthetase

NO Predicted

integral

membrane

protein

NO

mtb:TBMG_00206 NO NO NO Predicted

permease

NO

mtb:TBMG_00208 LabA_like proteins NYN domain,

limkain-b1-type

NYN domain NO 2qipA-17-76-7e-15

mtb:TBMG_00210 NO NO Ribosomal protein

S11 ; Pox virus Ag35

surface protein

NO 1mkyA-17-42-3e-04

mtb:TBMG_00211 NO NO Transcriptional

activator TraM

NO 1mkyA-27-36-0.010

mtb:TBMG_00217 FkbR2 is a

Streptomyces

hygroscopicus protein

with a hot dog fold that

belongs to a conserved

family of proteins

found in prokaryotes

and archaea but not in

eukaryotes.

Thiol ester

hydratase, Rv0216,

predicted

MaoC like domain Predicted acyl

dehydratase

2bi0A-100-345-6e-96

mtb:TBMG_00219 Sulfite oxidase (SO)

family, molybdopterin

binding domain.

Oxidoreductase,

molybdopterin-

binding domain

Oxidoreductase

molybdopterin

binding domain

Uncharacterized

enzymes, related

to nitrate

reductase

1ogpA-21-131-2e-31

mtb:TBMG_00220 NO NO Major Facilitator

Superfamily

NO NO

mtb:TBMG_00222 Wax ester synthase-like

Acyl-CoA

acyltransferase dom;

acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

C-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 2jgpA- 13- 94- 4e-20

mtb:TBMG_00226 Glycosyltransferase

[Cell envelope

biogenesis, outer

membrane]

Glycosyl

transferase, family 1

Glycosyl transferase

4-like domain ;

Glycosyl transferases

group 1

Predicted

glycosyltransfer

ases

3c48A-23-268 1e-72

mtb:TBMG_00227 NO NO NO NO 2pziA-11-37-9e-05

mtb:TBMG_00236 NO NO Lipase maturation

factor

NO NO

mtb:TBMG_00237 NO Coagulation factor

5/8 C-terminal type

domain; Galactose-

binding domain-like

F5/8 type C domain NO NO

mtb:TBMG_00243 The hotdog fold was

initially identified in

the E. coli FabA (beta-

hydroxydecanoyl-acyl

carrier protein (ACP)-

dehydratase) structure

and subsequently in

4HBT (4-

hydroxybenzoyl-CoA

thioesterase) from

Pseudomonas.; enoyl-

CoA hydratase

MaoC-like

dehydratase; Fatty

acid synthase

Metal-binding domain

of MaoC dehydratase ;

MaoC like domain

Predicted acyl

dehydratase

1s9cG-17-198-9e-52
















mtb:TBMG_00248 NO Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

NO 2cfqA-9-43-1e-04

mtb:TBMG_00260 NO Tetracycline

transcriptional

regulator, TetR-

related, C-terminal

NO NO 2np3A-22-111-4e-26

mtb:TBMG_00261 Sirohydrochlorin cobalt

chelatase (CbiX) and

sirohydrochlorin iron

chelatase (SirB), C-

terminal domain; N-

terminal domain;

Sirohydrochlorin

ferrochelatase

[Inorganic ion transport

and metabolism]

Cobalamin (vitamin

B12) biosynthesis

CbiX

CbiX Family Uncharacterized

ACR

2jh3A-18-106-5e-24

mtb:TBMG_00265 Allophanate hydrolase

subunit 2; This domain

forms the second

subunit of allophanate

hydrolase.

Allophanate

hydrolase subunit 2

Allophanate hydrolase

subunit 2

Allophanate

hydrolase

subunit 2

NO

mtb:TBMG_00266 Allophanate hydrolase

subunit 1 [Amino acid

transport and

metabolism]

Cyclophilin-like

peptidyl-prolyl cis-

trans isomerase

domain;

Allophanate

hydrolase subunit 1;

Arginine repressor

C-terminal-like

domain

Allophanate hydrolase

subunit 1

Allophanate

hydrolase

subunit 1

2phcB-25-180-2e-46

mtb:TBMG_00270 Phd_YefM; This

domain complexes with

pfam06769.

Bacteriophage P1,

prevent-host-death

protein

Antitoxin Phd_YefM,

type II toxin-antitoxin

system

NO 2a6qA-30-55-1e-08

mtb:TBMG_00271 LigD_Pol_like_2:

Polymerase (Pol)

domain of bacterial

LigD proteins similar

to Pseudomonas

aeruginosa (Pae) LigD,

subgroup 2.

DNA primase,

small subunit

Eukaryotic and

archaeal DNA primase

small subunit

Predicted

eukaryotic-type

DNA primase

2iruA-31-334-2e-92

mtb:TBMG_00274 Dipeptidyl

aminopeptidases/acyla

minoacyl-peptidases

[Amino acid transport

and metabolism]

NO Alpha/beta hydrolase

family

NO 1k8qA-11-48-3e-06

mtb:TBMG_00276 N-terminal domain of

Sphingobium

chlorophenolicum 2,6-

dichloro-p-

hydroquinone 1,2-

dioxygenase (PcpA),

and similar proteins.;

Glyoxalase/Bleomycin

resistance

protein/Dioxygenase

superfamily;

Extradiol ring-

cleavage

dioxygenase, class I

/II;

Glyoxalase/fosfomy

cin

resistance/dioxygen

ase


resistance

protein/Dioxygenase

superfamily

Lactoylglutathio

ne lyase and

related lyases

1zswA-14-100-3e-22

mtb:TBMG_00283 PE family; The PE

family of proteins all

contain an amino-

terminal region of

about 110 amino acids.

PE-PGRS family,

N-terminal

PE family NO NO












methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-42-232-5e-62

mtb:TBMG_00287 The AAA+ (ATPases

Associated with a wide

variety of cellular

Activities) superfamily

represents an ancient

group of ATPases

belonging to the ASCE

(for additional strand,

catalytic E) division of

the P-loop NTPase

fold; type VII secretion

AAA-ATPase EccA

CbxX/CfqX;

ATPase, AAA+

type, core; Type VII

secretion system

AAA-ATPase,

EccA

ATPase family

associated with

various cellular

activities (AAA)

ATPases of the

AAA+ class

no

mtb:TBMG_00288 NO Type VII secretion

system EccB

NO NO 2b5uA-20-42-4e-06

mtb:TBMG_00289 P-loop containing

Nucleoside

Triphosphate

Hydrolases; type VII

secretion protein EccCa

Cell division

protein

FtsK/SpoIIIE;

ATPase, AAA+


secretion system

EccCa; Type VII

secretion system

EccCb

FtsK/SpoIIIE family DNA

segregation

ATPase

FtsK/SpoIIIE

and related

proteins

NO

mtb:TBMG_00294 NO NO EspG family NO NO

mtb:TBMG_00295 type VII secretion

integral membrane

protein EccD

Type VII secretion

system EccD

WXG100 protein

secretion system

(Wss), protein YukD

NO 2b5uA-17-42-3e-04

mtb:TBMG_00298 Esterases and lipases

(includes fungal

lipases, cholinesterases,

etc.); Alpha/beta

hydrolase family


family

Hydrolases of

the alpha/beta

superfamily

1l7aA-14-74-4e-14

mtb:TBMG_00300 Stf0 sulphotransferase;

Members of this family

are essential for the

biosynthesis of

sulpholipid-1 in

prokaryotes.

Sulphotransferase

Stf0, domain

Stf0 sulphotransferase NO 1texD-67-307-2e-84

mtb:TBMG_00302 PE family; The PE

family of proteins all

contain an amino-

terminal region of

about 110 amino acids.

PE-PGRS family,

N-terminal

PE family NO NO

mtb:TBMG_00303 NO CopG-like DNA-

binding

Ribbon-helix-helix


NO 2bj7B-27-34-0.009


GTPase

NO

mtb:TBMG_00312 PAP2_like_2 proteins.

PAP2 is a super-family

of phosphatases and

haloperoxidases.

Phosphatidic acid

phosphatase type

2/haloperoxidase;

chloroperoxidase,

N-terminal

PAP2 superfamily Membrane-

associated

phospholipid

phosphatase

2ipbA-17-72-1e-13


catalytic domain

L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

NO NO















2 (NTF2-like)

superfamily. This

family includes

members of the NTF2

family, Delta-5-3-

ketosteroid isomerases,

Scytalone

Dehydratases, and the

beta subunit of Ring

hydroxylating

dioxygenases.

NO SnoaL-like domain NO 2chcA-20-89-6e-19

mtb:TBMG_00316 Molecular chaperone

[Posttranslational

modification, protein

turnover, chaperones]

Heat shock protein

Hsp70

Hsp70 protein Molecular

chaperone

2v7yA-18-731-0.0

mtb:TBMG_00318 NO NO Thiamine

pyrophosphokinase C

terminal ; Chitin

synthesis regulation,

resistance to Congo

red

NO 2b5uA-22-42-1e-04

mtb:TBMG_00327 GlcNAc-PI de-N-

acetylase; Members of

this family are related

to PIG-L an N-

acetylglucosaminylpho

sphatidylinositol de-N-

acetylase (EC:3.5.1.89)

that catalyses the

second step in GPI

biosynthesis.

N-

acetylglucosaminyl

phosphatidylinositol

deacetylase;

Putative deacetylase

LmbE-like domain

GlcNAc-PI de-N-

acetylase

Uncharacterized

proteins, LmbE

homologs

2ixdA-23-180-1e-46

mtb:TBMG_00330 S-adenosylmethionine-

dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

2p8jB-16-58-2e-09


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

1xtpA 16 107 3e-24


domains; A large

family of mostly alpha-

helical protein domains

with a characteristic

fold; Transcriptional

regulator

DNA-binding HTH

domain, TetR-type;

Homeodomain-like;

Tetracycline

transcriptional

regulator, TetR-like,

C-terminal

Bacterial regulatory

proteins, tetR family

Transcriptional

regulator

3bhqA-15-87-3e-18

mtb:TBMG_00336 DinB superfamily;

uncharacterized

Actinobacterial protein

TIGR03083

MDMPI C-

terminal;

Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain ; MDMPI C-

terminal domain

NO 2nsfA-13-73-9e-14


2 (NTF2-like)

superfamily. This

family includes

members of the NTF2

family, Delta-5-3-

ketosteroid isomerases,

Scytalone

Dehydratases, and the

NO SnoaL-like domain NO 1nwwB-18-40-2e-04










beta subunit of Ring

hydroxylating

dioxygenases.

mtb:TBMG_00344 NO NO NO NO 2r56H -26- 37- 0.002

mtb:TBMG_00360 PaaI_thioesterase is a

tetrameric acyl-CoA

thioesterase with a hot

dog fold and one of

several proteins

responsible for

phenylacetic acid (PA)

degradation in bacteria.

Thioesterase

superfamily

Thioesterase

superfamily

NO 2ov9C-22-153-3e-38

mtb:TBMG_00363 Uncharacterized

homologs of Site-2

protease (S2P), zinc

metalloproteases

(MEROPS family

M50) which cleave

transmembrane

domains of substrate

proteins, regulating

intramembrane

proteolysis (RIP) of

diverse signal

transduction

mechanisms.

Peptidase M50 Peptidase family M50 Zn-dependent

proteases

3b4rA-17-64-2e-11

mtb:TBMG_00365 NO NO Dystroglycan

(Dystrophin-

associated

glycoprotein 1) ;

Cytochrome C and

Quinol oxidase

polypeptide I ; MacB-

like periplasmic core

domain ; Putative

lumazine-binding

NO 2r4iA-14-40-6e-04

mtb:TBMG_00369 Glycosyl hydrolase

family 76; Family of

alpha-1,6-mannanases.

Glycoside

hydrolase, family

76; Six-hairpin

glycosidase-like;

Predicted O-

glycosyl hydrolase

Glycosyl hydrolase

family 76

NO 2ahfA-14-57-1e-08


Nucleoside

Triphosphate

Hydrolases; Predicted

kinase

Zeta toxin domain Zeta toxin ABC-type

cobalamin/Fe3+

-siderophores

transport

systems,

ATPase

components

1ltqA-19-59-7e-10

mtb:TBMG_00390 Member of the

Rhodanese Homology

Domain superfamily,

subgroup 1. This CD

includes the putative

rhodanese-related

sulfurtransferases of

several uncharacterized

proteins.

Rhodanese-like Rhodanese-like

domain

Rhodanese-

related

sulfurtransferase

s

2fsxA-94-168-3e-43

mtb:TBMG_00396 NO NO PLD-like domain NO NO









mtb:TBMG_00404 Mycobacterium

membrane protein; This

family contains several

membrane proteins

from Mycobacterium

species.

Mycobacterium

membrane

Mycobacterium

membrane protein

NO NO

mtb:TBMG_00413 NO NO Four helix bundle

sensory module for

signal transduction

NO NO

mtb:TBMG_00427 NO NO Secretion system

effector C (SseC) like

family

NO NO

mtb:TBMG_00429 NO NO NO NO 1yr0A-21-52-2e-07

mtb:TBMG_00431 NO NO Potential Monad-

binding region of

RPAP3

NO NO


DinB family are an


of potential enzymes.

The structure of these

proteins is composed of

a four helix bundle.

NO MAS20 protein import

receptor

NO 3cexA-36-165-8e-42

mtb:TBMG_00445 Anti-sigma-K factor

rskA; This domain,In

Mycobacterium

tuberculosis the protein

positively regulates

expression of the

antigenic proteins

MPB70 and MPB83.

Anti-sigma K factor

RskA

Anti-sigma-K factor

rskA

NO NO

mtb:TBMG_00447 soprenylcysteine

carboxyl

methyltransferase

(ICMT) family; The

isoprenylcysteine o-

methyltransferase

(EC:2.1.1.100) family

carry out carboxyl

methylation of cleaved

eukaryotic proteins that

terminate in a CaaX

motif.

NO NO NO NO

mtb:TBMG_00450 Rossmann-fold

NAD(P)(+)-binding

proteins; A large family

of proteins that share a

Rossmann-fold

NAD(P)H/NAD(P)(+)

binding (NADB)

domain; Predicted

NAD/FAD-binding

protein

Amine oxidase Flavin containing

amine oxidoreductase

Predicted

NAD/FAD-

binding protein

1reoA-18-135-1e-32


membrane protein

Mycobacterium

membrane

Mycobacterium

membrane protein

NO NO

mtb:TBMG_00456 NO NO NO NO 1ihuA-15-37-0.003

mtb:TBMG_00465 NO NO Multidrug resistance

efflux transporter

NO NO

mtb:TBMG_00466 Carboxymuconolactone

decarboxylase family;

Carboxymuconolactone

decarboxylase (CMD)

EC:4.1.1.44 is involved

in protocatechuate

Carboxymuconolact

one decarboxylase

Carboxymuconolacton

e decarboxylase

family

Uncharacterized

ACR

2oyoA-19-102-3e-23














catabolism.


thioesterase (4HBT);

Acyl-ACP thioesterase

[Lipid metabolism]

Acyl-ACP

thioesterase

Acyl-ACP

thioesterase

Predicted

thioesterase

2ownB-18-213-3e-56

mtb:TBMG_00473 UbiA prenyltransferase

family;

UbiA

prenyltransferase

family

UbiA

prenyltransferase

family

1,4-dihydroxy-

2-naphthoate

octaprenyltransf

erase

NO

mtb:TBMG_00474 NO NO UbiA

prenyltransferase

family

NO NO


protein

transmembrane UME (NUC010)

domain

Uncharacterized

membrane

protein

1w3wA-14-38-0.003

mtb:TBMG_00479 NO NO PRA1 family protein ;

Dolichol-phosphate

mannosyltransferase

subunit 3 (DPM3);

Tripartite

tricarboxylate

transporter TctB

family; Prokaryotic

cytochrome b561 ;

Phospholipase_D-

nuclease N-terminal

NO NO

mtb:TBMG_00490 NO NO Putative bacterial

sensory transduction

regulator

NO 2plgA-20-39-6e-04

mtb:TBMG_00501 Ppx/GppA phosphatase

family; This family

consists of the N-

terminal region of

exopolyphosphatase

(Ppx) EC:3.6.1.11 and

guanosine

pentaphosphate

phospho-hydrolase

(GppA) EC:3.6.1.40.

Ppx/GppA

phosphatase

Ppx/GppA

phosphatase family

Exopolyphospha

tase

1u6zB-21-325-6e-90

mtb:TBMG_00502 NO NO Amino acid permease

; 7TM diverse

intracellular

signalling; Poxvirus

virion envelope

protein A14

NO 1jhnA-9-38-0.002

mtb:TBMG_00503 P endonuclease family

2; These endonucleases

play a role in DNA

repair; Sugar phosphate

isomerases/epimerases


and metabolism]

Xylose isomerase,

TIM barrel domain

Xylose isomerase-like

TIM barrel

Sugar phosphate

isomerases/epim

erases

2qulA-16-133-5e-32

mtb:TBMG_00504 Diacylglycerol kinase

catalytic domain;

Diacylglycerol (DAG)

is a second messenger

that acts as a protein

kinase C activator; The

hotdog fold was

initially identified in

the E. coli FabA (beta-

hydroxydecanoyl-acyl

Diacylglycerol

kinase, catalytic

domain

Thioesterase-like

superfamily

NO 3bbjA 25 186 3e-48











carrier protein (ACP)-

dehydratase) structure

and subsequently in

4HBT (4-

hydroxybenzoyl-CoA

thioesterase) from

Pseudomonas

mtb:TBMG_00506 Helix-Turn-Helix DNA

binding domain of

transcription regulators

from the MerR

superfamily

Excisionase/Xis,

DNA-binding

Helix-turn-helix

domain

NO NO

mtb:TBMG_00507 NO NO Mitochondrial domain

of unknown function

NO NO

mtb:TBMG_00509 Lysophospholipid

Acyltransferases

(LPLATs) of

Glycerophospholipid

Biosynthesis: MGAT-

like; Lysophospholipid

acyltransferase

(LPLAT) superfamily

member

Phospholipid/glycer

ol acyltransferase

Acyltransferase 1-acyl-sn-

glycerol-3-

phosphate

acyltransferase

1iuqA-11-70-1e-12

mtb:TBMG_00511 (R)-hydratase [(R)-

specific enoyl-CoA

hydratase]. Catalyzes

the hydration of trans-

2-enoyl CoA to (R)-3-

hydroxyacyl-CoA as

part of the PHA

(polyhydroxyalkanoate)

biosynthetic pathway.

MaoC-like

dehydratase

Metal-binding domain

of MaoC dehydratase

NO 2bi0A-15-69-7e-13


membrane protein

Mycobacterium

membrane

Mycobacterium

membrane protein

NO NO

mtb:TBMG_00515 Protein Disulfide

Oxidoreductases and

Other Proteins with a

Thioredoxin fold; The

thioredoxin (TRX)-like

superfamily is a large,

diverse group of

proteins containing a

TRX fold.

Glutaredoxin-like;

Thioredoxin-like

fold

Glutaredoxin-like

domain

Thiol-disulfide

isomerase and

thioredoxins

1wjkA-21-81-4e-17

mtb:TBMG_00523 Sulphate Transporter

and Anti-Sigma factor

antagonist) domain of

anti-anti-sigma factors,

key regulators of anti-

sigma factors by

phosphorylation; Anti-

anti-sigma factors play

an important role in the

regulation of several

sigma factors and their

corresponding anti-

sigma factors

Sulphate

transporter/antisigm

a-factor antagonist

STAS

STAS domain Anti-anti-sigma

regulatory factor

(antagonist of

anti-sigma

factor)

1th8B-22-44-2e-05

mtb:TBMG_00525 SGNH_hydrolase, or

GDSL_hydrolase, is a

diverse family of

lipases and esterases.

Esterase, SGNH

hydrolase-type

GDSL-like

Lipase/Acylhydrolase

family

Molecular

chaperone

2o14A-15-55-1e-08

mtb:TBMG_00526 Enterochelin esterase

and related enzymes


and metabolism]

Putative esterase;

Twin-arginine

translocation

pathway, signal

sequence

Putative esterase NO 3c8dB-19-107-5e-24










mtb:TBMG_00530 NO Deazaflavin-

dependent

nitroreductase

NO NO NO

mtb:TBMG_00532 Histidine phosphatase

domain found in

phosphoglycerate

mutases and related

proteins, mostly

phosphatases

Histidine

phosphatase

superfamily, clade-

1

Histidine phosphatase

superfamily (branch 1)

Fructose-2,6-

bisphosphatase

h2eA-24-102-9e-23

mtb:TBMG_00537 ParA and ParB of

Caulobacter crescentus

belong to a conserved

family of bacterial

proteins implicated in

chromosome

segregation; Type 1

glutamine

amidotransferase

(GATase1)-like

domain; cell division

ATPase MinD, archaeal

Cobyrinic acid a,c-

diamide synthase

AAA domain ATPases

involved in

chromosome

partitioning

1wcv1-24-171-3e-43


family A (GT-A)

includes diverse

families of glycosyl

transferases with a

common GT-A type

structural fold.

NO Putative cell wall

binding repeat 2

Uncharacterized

BCR

3cgxA-24-113-5e-26

mtb:TBMG_00547 NO NO Uncharacterized BCR NO 2b5uA-26-47-1e-05

mtb:TBMG_00550 NO NO ABC-2 family

transporter protein ;

Cytochrome b(N-

terminal)/b6/petB ;

Photosystem II protein

Y (PsbY)

NO NO

mtb:TBMG_00551 Phosphate transporter

family; This family

includes PHO-4 from

Neurospora crassa

which is a is a Na(+)-

phosphate symporter.

This family also

contains the leukaemia

virus receptor.

Phosphate

transporter

Phosphate transporter

family

Phosphate/sulph

ate permeases

NO

mtb:TBMG_00552 This domain

superfamily is found in

a variety of structurally

related metalloproteins,

including the type I

extradiol dioxygenases,

glyoxalase I and a

group of antibiotic

resistance proteins.;


resistance

protein/Dioxygenase

superfamily

NO Glyoxalase-like

domain

Lactoylglutathio

ne lyase and

related lyases

3bqxA-21-67-7e-13

mtb:TBMG_00574 NO Plasmid

maintenance

toxin/Cell growth

inhibitor

NO NO 2a7yA-61-109-3e-25

mtb:TBMG_00576 Phosphoribosyl

transferase domain;

Esterases and lipases

(includes fungal

Phosphoribosyltrans

ferase

Phosphoribosyl

transferase domain;

lpha/beta hydrolase

family

Predicted

phosphoribosyltr

ansferases

2o2gA-58-159-2e-39












etc.) ; Alpha/beta

hydrolase family

mtb:TBMG_00579 CapA and related

proteins,

metallophosphatase

domain; Putative

enzyme of poly-

gamma-glutamate

biosynthesis (capsule

formation) [Cell

envelope biogenesis,

outer membrane]

Capsule synthesis

protein, CapA

Bacterial capsule

synthesis protein

PGA_cap

Putative enzyme

of poly-gamma-

glutamate

biosynthesis

(capsule

formation)

2z1aA-20-66-1e-11


NAD(P)(+)-binding

proteins;

Monooxygenase,

FAD-binding;

Aromatic-ring

hydroxylase-like

FAD binding domain 2-polyprenyl-6-

methoxyphenol

hydroxylase and

related FAD-

dependent

oxidoreductases

2qa2A-17-176-6e-45

mtb:TBMG_00582 N-terminal domain of

Streptomyces griseus

SgaA (suppression of

growth disturbance

caused by A-factor at a

high concentration

under high osmolality

during early growth

phase);

NO Glyoxalase-like

domain

Predicted

enzyme related

to

lactoylglutathion

e lyase

3b59A-16-57-6e-09

mtb:TBMG_00586 NO Beta-grasp fold,

ferredoxin-type

Ub domain fused to

Mut7-C

Uncharacterized

ACR

NO

mtb:TBMG_00587 NO Rubromycin-type

polyketide

biosynthesis

protein,

GrhN/RubW,

predicted

NO NO NO


family 92; Members of

this family are alpha-

1,2-mannosidases,

enzymes which remove

alpha-1,2-linked

mannose residues from

Man(9)(GlcNAc)(2) by

hydrolysis; Putative

alpha-1,2-mannosidase


and metabolism]

Alpha-1,2-

mannosidase,

putative; Six-

hairpin glycosidase-

like; Glycosyl

hydrolase 92

Glycosyl hydrolase

family 92

Putative alpha-

1,2-mannosidase

NO

mtb:TBMG_00592 Predicted integral

membrane protein

Lysylphosphatidylg

lycerol synthetase

Protein kinase domain Predicted

integral

membrane

protein

NO


toluene export

system,

permease

component

NO










toluene export

system,

permease

component

NO

mtb:TBMG_00605 Predicted ATPase

(AAA+ superfamily)

NO AAA domain Uncharacterized

ATPases of the

AAA

superfamily

1in4A-18-52-1e-07

mtb:TBMG_00610 NO NO Peptidase propeptide

and YPEB domain

NO NO

mtb:TBMG_00621 SEC-C motif; The

SEC-C motif found in

the C-terminus of the

SecA protein, in the

middle of some SWI2

ATPases and also solo

in several proteins.

SEC-C motif SEC-C motif Preprotein

translocase

subunit SecA

(ATPase, RNA

helicase)

NO

mtb:TBMG_00630 NO NO zinc-ribbon domain ;

Alphaherpesvirus

glycoprotein E

NO NO

mtb:TBMG_00631 NO NO Double zinc ribbon NO NO

mtb:TBMG_00634 SNARE associated

Golgi protein; This is a

family of SNARE

associated Golgi

proteins. The yeast

member of this family

localises with the t-

SNARE Tlg2.

NO SNARE associated

Golgi protein

Uncharacterized

membrane-

associated

protein

NO

mtb:TBMG_00637 FIST N domain; The

FIST N domain is a

novel sensory domain,

which is present in

signal transduction

proteins from Bacteria,

Archaea and Eukarya.;

FIST C domain;

FIST domain, N-

terminal; FIST C

domain

FIST N domain ; FIST

C domain

NO NO

mtb:TBMG_00658 Aminoglycoside 3'-

phosphotransferase

(APH) and Choline

Kinase (ChoK) family;

Predicted unusual

protein kinase

Protein kinase,

catalytic domain;

ABC-1

ABC1 family Predicted

unusual protein

kinase

1o6yA-13-55-2e-08

mtb:TBMG_00678 NO NO P-loop containing

NTP hydrolase pore-1

NO NO


membrane protein

Mycobacterium

membrane

Mycobacterium

membrane protein

Cytochrome c

biogenesis

factor

NO

mtb:TBMG_00691 NO Winged helix-turn-

helix transcription

repressor DNA-

binding

MarR family NO 1ku9A-13-54-2e-08

mtb:TBMG_00692 NO NO F-actin binding NO NO














mtb:TBMG_00699 NO NO Short C-terminal

domain

NO NO

mtb:TBMG_00702 NO NO Glyoxalase-like

domain

NO NO

mtb:TBMG_00705 mycofactocin system

RPExFGAL protein;

Families TIGR03969

and TIGR03962

describe, respectively,

the putative

mycofactocin precursor

and its cognate radical

SAM peptide maturase.

NO NO NO NO

mtb:TBMG_00708 Creatinine

amidohydrolase;

Creatinine

amidohydrolase

(EC:3.5.2.10), or

creatininase, catalyses

the hydrolysis of

creatinine to creatine.

Creatininase/forma

mide hydrolase;

Creatininase,

actinobacteria

Creatinine

amidohydrolase

Uncharacterized

protein, putative

amidase

1v7zA-25-198-6e-52


binding domain of


from the MerR

superfamily; Helix-

turn-helix (HTH)

transcription regulator

MerR superfamily, N-

terminal domain.

NO NO NO 3c7jA-19-37-0.002

mtb:TBMG_00726 Formylglycine-

generating sulfatase

enzyme; This domain is

found in eukaryotic

proteins required for

post-translational

sulphatase modification

(SUMF1).

Formylglycine-

generating

sulphatase enzyme

domain; C-type

lectin fold

Formylglycine-


enzyme

Uncharacterized

BCR

2q17E-44-258-9e-70


methyltransferase;

Family of leucine

carboxyl

methyltransferases

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-43-203-5e-53

mtb:TBMG_00744 N-Acyltransferase

superfamily

GCN5-related N-

acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain

NO 2inrA-22-99-6e-22


methyltransferase;

Family of leucine

carboxyl

methyltransferases

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-41-231-1e-61

mtb:TBMG_00750 Predicted

transmembrane

transcriptional regulator

(anti-sigma factor)

[Transcription]

NO Putative zinc-finger NO 2q1zB-36-50-8e-07











mtb:TBMG_00752 DinB superfamily;

uncharacterized

Actinobacterial protein

TIGR03083

Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain

NO 2nsfA-14-58-2e-09


BssS (also known as

YliH) regulates


biofilm formation

through quorum

sensing.

NO GAF domain NO NO

mtb:TBMG_00759 helicase/secretion

neighborhood putative

DEAH-box helicase

NO NO NO NO

mtb:TBMG_00761 NO PE-PGRS family,

N-terminal

PE family NO NO

mtb:TBMG_00771 NO NO DASH complex

subunit Dad2

3,4-dihydroxy-

2-butanone 4-

phosphate

synthase

NO

mtb:TBMG_00774 HIT family: HIT

(Histidine triad)

proteins, named for a

motif related to the

sequence HxHxH/Qxx

(x, a hydrophobic

amino acid), are a

superfamily of

nucleotide hydrolases

and transferases, which

act on the alpha-

phosphate of

ribonucleotides.

Histidine triad

(HIT) protein,

conserved site

HIT domain Diadenosine

tetraphosphate

(Ap4A)

hydrolase and

other HIT

family

hydrolases

1y23B-29-159-2e-40


2 (NTF2-like)

superfamily.

NO SnoaL-like domain NO 2bngC-16-43-6e-05

mtb:TBMG_00782 NO DNA-binding HTH

domain, TetR-type;

Homeodomain-like;

Tetracycline

transcriptional


C-terminal



Transcriptional

regulator

3bjbB-22-83-2e-17


(includes fungal


etc.)

Twin-arginine

translocation

pathway, signal

sequence

Putative esterase Predicted

esterase

3c8dB-19-75-2e-14


domain, TetR-type;

Homeodomain-like;

Tetracycline

transcriptional


C-terminal



NO 2qkoB-21-56-5e-09

mtb:TBMG_00794 NO NO GXGXG motif NO NO












mtb:TBMG_00797 NO NO tRNA Pseudouridine

synthase II, C terminal

NO 2g9dA-29-34-0.009

mtb:TBMG_00799 Putative catalytic

domain of

uncharacterized

bacterial proteins from

the carbohydrate

esterase 4 superfamily;

Predicted deacetylase

NO NO Predicted

deacetylase

NO

mtb:TBMG_00801 Metallo-beta-lactamase

superfamily

Beta-lactamase-like Beta-lactamase

superfamily domain

Predicted Zn-

dependent

hydrolases of

the beta-

lactamase fold

1zkpA-13-60-2e-10



regulator

NO NO

mtb:TBMG_00806 Transglutaminase-like

superfamily; This

family includes animal

transglutaminases and

other bacterial proteins

Transglutaminase-

like

Transglutaminase-like

superfamily

Transglutaminas

e-like enzymes,

putative cysteine

proteases

2f4mA-16-53-5e-08

mtb:TBMG_00807 Flavin-utilizing

monoxygenases;

probable F420-

dependent

oxidoreductase,

Rv1855c family

Luciferase-like,

F420-dependent

oxidoreductase,

Rv2161c, predicted

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

2b81C-21-225-1e-59

mtb:TBMG_00809 Antibiotic biosynthesis

monooxygenase

Antibiotic

biosynthesis

monooxygenase;

Dimeric alpha-beta

barrel

Antibiotic

biosynthesis

monooxygenase

Uncharacterized

ACR

1y0hA-100-114-3e-27

mtb:TBMG_00813 Dyp-type peroxidase

family; This family of

dye-decolourising

peroxidases lack a

typical heme-binding

region.

Dyp-type

peroxidase; Dimeric

alpha-beta barrel

Dyp-type peroxidase

family

Predicted iron-

dependent

peroxidase

2gvkA-48-373-1e-104

mtb:TBMG_00815 Glyoxalase/Bleomycin

resistance

protein/Dioxygenase

superfamily;

NO Glyoxalase-like

domain

NO 2rbbA-19-41-2e-04

mtb:TBMG_00816 Acetyltransferases,

including N-acetylases

of ribosomal proteins

[Translation, ribosomal

structure and

biogenesis]

GCN5-related N-

acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain

Acetyltransferas

es, including N-

acetylases of

ribosomal

proteins

2fckA-23-119-5e-28

mtb:TBMG_00818 CAAX amino

terminal protease

CAAX protease self-

immunity

Predicted metal-

dependent

membrane

protease

NO

Abi super family,

CAAX amino terminal

protease self- immunity












mtb:TBMG_00819 Enterobacter aerogenes

GpdQ and related

proteins,

metallophosphatase

domain; Predicted

phosphohydrolases

Metallophosphoeste

rase domain

Calcineurin-like

phosphoesterase

Predicted

phosphohydrola

ses

2hy1A-88-205-7e-54

mtb:TBMG_00825 folate-binding protein

YgfZ; Predicted

aminomethyltransferase

related to GcvT

Glycine cleavage T-

protein, N-terminal;

C-terminal barrel;

YgfZ/GcvT

conserved site

Aminomethyltransfera

se folate-binding

domain; Glycine

cleavage T-protein C-

terminal barrel domain

Predicted

aminomethyltra

nsferase related

to GcvT

1vloA-20-68-5e-12

mtb:TBMG_00827 nitrobindin heme-

binding domain

Calycin-like NO NO 2fwvA-95-253-2e-68

mtb:TBMG_00828 NO Carbohydrate-

binding-like fold;

Carboxypeptidase,

regulatory domain

Bacterial Ig-like

domain (group 1) ;

FixH

NO NO

mtb:TBMG_00836 Cell envelope-related

transcriptional

attenuator domain

Cell envelope-

related

transcriptional

attenuator

Cell envelope-related

transcriptional

attenuator domain ;

LytR cell envelope-

related transcriptional

attenuator

Transcriptional

regulator

2pziA-7-33-0.001


domain, TetR-type;

Homeodomain-like;

Tetracycline

transcriptional


C-terminal


proteins, tetR family ;

Bacterial

transcriptional

repressor ; Glycosyl

hydrolase catalytic

core

NO 1ui5B-16-60-4e-10


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-42-2302e-61

mtb:TBMG_00862 Mechanosensitive ion

channel

Mechanosensitive

ion channel MscS;

transmembrane-2;

Like-Sm

ribonucleoprotein

(LSM)-related

domain;

Mechanosensitive

ion channel MscS,

C-terminal

Mechanosensitive ion

channel

Small-

conductance

mechanosensitiv

e channel

2oauA-17-212-8e-56


DinB family are an


of potential enzymes;

MDMPI C-

terminal;Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain ; MDMPI C-

terminal domain

NO 2nsfA-12-110-5e-25

MDR super family,

Medium chain

reductase/dehydrogenas

e (MDR)/zinc-

dependent alcohol

dehydrogenase-like

family;

mtb:TBMG_00869 NO NO NO PLP-dependent

aminotransferas

es

NO










mtb:TBMG_00871 Cellulase (glycosyl

hydrolase family 5)

Glycoside

hydrolase,

subgroup, catalytic

domain; putative

cellulase

Sugar-binding

cellulase-like

NO 1uuqA-13-73-6e-14

mtb:TBMG_00873 Acyl-CoA

dehydrogenase; Acyl-

CoA dehydrogenases

[Lipid metabolism]

Acyl-CoA

oxidase/dehydrogen

ase, central domain;

Acyl-CoA

dehydrogenase, N-

terminal; Acyl-CoA

dehydrogenase/oxid

ase C-terminal

Acyl-CoA

dehydrogenase, N-

terminal domain; C-

terminal domain

Acyl-CoA

dehydrogenases

2or0B-24-145-2e-35


BCR

NO

mtb:TBMG_00876 Patatins and

Phospholipases

Patatin/Phospholipa

se A2-related; Acyl

transferase/acyl

hydrolase/lysophos

pholipase

Patatin-like

phospholipase

NO 1qyrA-13-31-0.006

mtb:TBMG_00877 The band 7 domain of

flotillin (reggie) like

proteins; Membrane

protease subunits,

stomatin/prohibitin

homologs

[Posttranslational



Band 7 protein SPFH domain / Band

7 family

Membrane

protease

subunits,

stomatin/prohibi

tin homologs

3bk6A-13-44-4e-05


Acyl-CoA

acyltransferase domain;

Acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

C-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 2jgpA-14-62-2e-10


Acyl-CoA


Acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

C-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 1q9jB-10-49-2e-06

mtb:TBMG_00886 Nucleotidyl transferase NO Nucleotidyl

transferase;

Photosystem I reaction

centre subunit VI

NO 2ewrA-20-38-0.007


monoxygenases;

probable F420-

dependent

oxidoreductase,

Rv2161c family;

Luciferase-like,

F420-dependent

oxidoreductase,

Rv2161c

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

2b81C-20-164-2e-41

mtb:TBMG_00891 Pyrabactin resistance 1

(PYR1), PYR1-like

(PYL), regulatory

component of abscisic

acid receptors

(RCARs), and related

proteins

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2d4rA-20-46-4e-06











mtb:TBMG_00892 Pyruvate kinase (PK) Aldehyde-lyase

domain; Citrate

lyase, beta subunit;

Pyruvate/Phosphoe

nolpyruvate kinase

HpcH/HpaI

aldolase/citrate lyase

family

Citrate lyase

beta subunit

1u5hA-31-157-3e-39

mtb:TBMG_00893 HNH nuclease HNH endonuclease NO 1uzbA-25-38-0.005

HNH nucleases


BCR

NO


monoxygenases

Luciferase-like

domain

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

1lucA-15-93-3e-20

mtb:TBMG_00896 Uncharacterized ACR Nitrogen regulatory

protein PII/ATP

phosphoribosyltrans

ferase, C-terminal

Uncharacterized ACR Uncharacterized

ACR

2dclA-22-80-6e-16

mtb:TBMG_00902 Small Multidrug

Resistance protein

Small multidrug

resistance protein

family

Small Multidrug

Resistance protein

Membrane

transporters of

cations and

cationic drugs

NO

mtb:TBMG_00903 DoxX protein family

YphA

DoxX Predicted

membrane

protein

NO

mtb:TBMG_00913 NADPH-dependent

FMN reductase

NADPH-dependent

FMN reductase

NADPH-dependent

FMN reductase

Predicted

flavoprotein

1rttA-30-136-4e-33

mtb:TBMG_00929 NO NUDIX hydrolase

domain

NUDIX domain NO NO

mtb:TBMG_00931 Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

1vl5A-15-103-8e-23

S-adenosylmethionine-

dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

mtb:TBMG_00932 NO NO Methyltransferase

domain

SAM-dependent

methyltransferas

es

2qm3A-13-42-2e-04

mtb:TBMG_00934 FOG: WD40-like

repeat

Pyrrolo-quinoline

quinone repeat;

Quinonprotein

alcohol

dehydrogenase-like

PQQ-like domain Uncharacterized

proteins of

WD40-like

repeat family

1l0qA-15-59-1e-09

mtb:TBMG_00936 NO NO D-aminopeptidase ;

Bacterial Ig-like

domain (group 3)

NO NO

mtb:TBMG_00938 NO Glycoside

hydrolase, family

Glycosyl hydrolase

family 57

Uncharacterized

ACR

1ufaA-30-433-1e-122















57, N-terminal;

Glycoside

hydrolase/deacetyla

se, beta/alpha-barrel


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I;

tocopherol O-

methyltransferase

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

1p91A-22-135-9e-33


superfamily

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain

Uncharacterized

BCR, putative

hemolysin

1ro5A-16-95-3e-20


Acyltransferases

(LPLATs) of

Glycerophospholipid

Biosynthesis: AGPAT-

like

Phospholipid/glycer

ol acyltransferase


glycerol-3-

phosphate

acyltransferase

1iuqA-17-47-7e-06

mtb:TBMG_00955 CIMS - Cobalamine-

independent methonine

synthase, or MetE

Methionine

synthase, vitamin-

B12 independent

Cobalamin-

independent synthase,

Catalytic domain

NO 1u1jA-19-67-3e-12

mtb:TBMG_00957 ACT_MalLac-Enz CD

includes the N-terminal

ACT domain of

putative NAD-

dependent malic

enzyme 1, Bacillus

subtilis YqkI and

related domains

NO ACT domain ; Shal-

type voltage-gated

potassium channels

NO NO

mtb:TBMG_00962 MgtC family NO NO

SapB, Uncharacterized

membrane protein

NO


YphA

DoxX Predicted

membrane

protein

NO


NAD(P)(+)-binding

proteins; Phytoene

dehydrogenase and

related proteins



and catabolism]

NO NAD(P)-binding

Rossmann-like

domain

Phytoene

dehydrogenase

and related

proteins

1s3eA-14-61-3e-10


phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain; F420-

binding domain,

putative

Pyridoxamine 5'-

phosphate oxidase

Putative heme

iron utilization

protein

1rfeA-99 -194-6e-51











dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

NO Methyltransferase

domain

NO 1dusA-12-37-0.006

mtb:TBMG_00995 DAK2 domain; This

domain is the predicted

phosphatase domain of

the dihydroxyacetone

kinase family; DAK2

domain fusion protein

YloV

Dak phosphatase DAK2 domain Predicted kinase

related to

dihydroxyaceton

e kinase

2btdA-12-39-2e-04

mtb:TBMG_00996 DAK2 domain; DAK2

domain fusion protein

YloV

Dak phosphatase;

DAK2 domain-

containing protein

YloV

DAK2 domain;

Dihydroxyacetone

kinase family

Predicted kinase

related to

dihydroxyaceton

e kinase

1un8A-20-69-2e-12

mtb:TBMG_01001 Protein-disulfide

isomerase

[Posttranslational



Thioredoxin-like

fold

Thioredoxin Protein-disulfide

isomerase

1z6mA-15-80-5e-16

mtb:TBMG_01002 Vitamin K epoxide

reductase family

Vitamin K epoxide

reductase

Vitamin K epoxide

reductase family

NO NO

mtb:TBMG_01008 Predicted permease transmembrane Predicted permease Predicted

permeases

NO


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

FkbM

Methyltransferase

FkbM domain

SAM-dependent

methyltransferas

es

3ccfB-12-48-2e-06


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

FkbM

Methyltransferase

FkbM domain

SAM-dependent

methyltransferas

es

2yx1A-15-68-2e-12


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I


domain

SAM-dependent

methyltransferas

es

3ccfB-17-86-4e-18


NAD(P)(+)-binding

proteins

Saccharopine

dehydrogenase /

Homospermidine

synthase; NAD(P)-

binding domain

Saccharopine

dehydrogenase

Uncharacterized

ACR

1yxmA-16-53-1e-07

mtb:TBMG_01022 UTRA domain; It is

believed to modulate

activity of bacterial

transcription factors in

response to binding

small molecules.

NO NO 4-

Hydroxybenzoat

e synthetase

(chorismate

lyase)

2nwiA-24-154-9e-39












mtb:TBMG_01044 Mitochondrial ATP

synthase B chain

precursor (ATP-

synt_B); Cell division

initiation protein [Cell

division and

chromosome

partitioning]

NO DivIVA protein ; ATP

synthase B/B' CF(0)

Archaeal/vacuol

ar-type H+-

ATPase subunit

E

2i1jA-13-38-0.001

mtb:TBMG_01045 NO NO Uncharacterized ACR Predicted metal-

binding,

possibly nucleic

acid-binding

protein

NO

mtb:TBMG_01048 OsmC-like protein;

Osmotically inducible

protein C (OsmC) is a

stress -induced protein

found in E. Coli.

Peroxiredoxin,

OsmC-like protein;

K homology

domain-like,

alpha/beta

OsmC-like protein NO 2e8eA-19-84-6e-18

mtb:TBMG_01055 DEAD-like helicases

superfamily. A diverse

family of proteins

involved in ATP-

dependent RNA or

DNA unwinding;

Helicase superfamily c-

terminal domain;

associated with

DEXDc-, DEAD-, and

DEAH-box proteins,

yeast initiation factor

4A, Ski2p, and

Hepatitis C virus NS3

helicases; DNA or

RNA helicases of

superfamily II

[Transcription / DNA

replication,

recombination, and

repair]

Helicase, C-

terminal;

Helicase/UvrB

domain; DEAD-like

helicase

Type III restriction

enzyme, res subunit ;

Helicase conserved C-

terminal domain

DNA or RNA

helicases of

superfamily II

2va8B-16-100-7e-22

mtb:TBMG_01057 Metallo-dependent

hydrolases;

Imidazolonepropionase

and related

amidohydrolases



and catabolism]

Amidohydrolase 1 Amidohydrolase Imidazolonepro

pionase and

related

amidohydrolases

2p9bA-24-199-5e-52


2 (NTF2-like)

superfamily.

NO SnoaL-like domain NO 3b8lA-31-92-6e-20

mtb:TBMG_01064 NO K Homology,

prokaryotic type

KH domain Predicted RNA-

binding protein

(KH domain)

NO








mtb:TBMG_01067 Penicillin binding

protein transpeptidase

domain

Beta-

lactamase/transpepti

dase-like

Beta-lactamase

enzyme family

NO 2j9oD-18-192-7e-50

mtb:TBMG_01076 Possible lysine

decarboxylase;

Predicted Rossmann

fold nucleotide-binding

protein involved in

DNA uptake [DNA

replication,

recombination, and

repair / Intracellular

trafficking and

secretion]

DNA

recombination-

mediator protein A;

Winged helix-turn-

helix transcription

repressor DNA-

binding

DNA recombination-

mediator protein A

Predicted

Rossmann fold

nucleotide-

binding protein

involved in

DNA uptake

1wekA-17-42-2e-04

mtb:TBMG_01093 LysE type translocator Cytochrome c

assembly protein,

transmembrane

domain

Cytochrome C

biogenesis protein


NO NO


acetyltransferase

GCN5-related N-

acetyltransferase

(GNAT) domain;

FR47-like; Acyl-

CoA N-

acyltransferase

FR47-like protein Predicted

acetyltransferase

1p0hA-18-63-8e-11

mtb:TBMG_01108 NO NO Cell wall-active

antibiotics response

protein

NO NO


Nucleoside

Triphosphate

Hydrolases

Cobalamin (vitamin

B12) biosynthesis

CobW-like

CobW/HypB/UreG,

nucleotide-binding

domain

Ni2+-binding

GTPase

involved in

regulation of

expression and

maturation of

urease and

hydrogenase

2hf9A-27-66-2e-12


Nucleoside

Triphosphate

Hydrolases

Cobalamin (vitamin

B12) biosynthesis

CobW-like

CobW/HypB/UreG,

nucleotide-binding

domain

Ni2+-binding

GTPase

involved in

regulation of

expression and

maturation of

urease and

hydrogenase

2hf9A-30-135-2e-33

mtb:TBMG_01116 High-affinity nickel-

transport protein

Nickel/cobalt

transporter, high-

affinity, bacteria

High-affinity nickel-

transport protein

High-affinity

nickel permease

NO

mtb:TBMG_01118 Esterases and lipases;

Lysophospholipase

[Lipid metabolism]


family

Lysophospholip

ase

2q0xA-14-93-1e-19


superfamily

GCN5-related N-

acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain

Predicted

acyltransferases

1xebA-40-161-6e-41

mtb:TBMG_01128 Ferritin-like

superfamily of diiron-

containing four-helix-

bundle proteins

Ferritin-related no no 2ib0A -100- 155 -3e-

39












mtb:TBMG_01129 no Twin-arginine

translocation

pathway, signal

sequence

TAT (twin-arginine

translocation) pathway

signal sequence ;

Secretion system

effector C (SseC) like

family ; SpaB C-

terminal domain

no no

mtb:TBMG_01130 The eukaryotic Sm and

Sm-like (LSm)

proteins; Mitochondrial

ATP synthase g

subunit; ribosome

maturation protein

RimP; Reviewed

Ribosome

maturation factor

RimP

YhbC family Uncharacterized

BCR

1ib8A -18- 121 -2e-28

mtb:TBMG_01132 Ylxr homologs no no no 1g2rA -23 -81 -4e-17

mtb:TBMG_01137 Transmembrane

subunit (TM) found in

Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters

which generally bind

type 2 PBPs; ABC-type

sugar transport system,

permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

ABC-type sugar

transport

systems,

permease

components

2r6gF- 22- 262- 8e-71



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters




permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

Sugar permeases 2r6gG -25 -194- 1e-50

mtb:TBMG_01146 no no no no 1zelB -98 -536- 1e-153

mtb:TBMG_01147 Nucleotidyl transferase no Nucleotidyl

transferase

no no

mtb:TBMG_01149 CRISPR/Cas system-

associated RAMP

superfamily protein

Cas6

CRISPR-associated

protein, Cas6;

CRISPR-associated

protein Cas6

domain

no no no










associated protein

Cas10; Predicted

CRISPR-associated

polymerase [Defense

mechanisms]

Diguanylate

cyclase, predicted;

CRISPR-associated

protein Csm1; HD

domain

HD domain ;

CRISPR-associated

protein ; Vacuolar

sorting protein 39

domain 1

Predicted

hydrolase of the

HD superfamily

(permuted

catalytic motifs)

no


associated protein

Csm2

CRISPR-associated

protein, TM1810 C-

terminal

no no no


associated protein

Csm6

CRISPR-associated

protein Csm6

CRISPR-associated

protein (Cas_Csm6)

no no



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters




permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

Sugar permeases 2r6gG-25-194-1e-50

mtb:TBMG_01146 NO NO NO NO 1zelB-98-536-1e-153


transferase

NO


associated RAMP

superfamily protein

Cas6

CRISPR-associated

protein, Cas6

NO NO NO


associated protein

Cas10; Predicted

CRISPR-associated

polymerase [Defense

mechanisms]

Diguanylate

cyclase, predicted;

CRISPR-associated

protein Csm1; HD

domain

HD domain ;

CRISPR-associated

protein; Vacuolar

sorting protein 39

domain 1

Predicted

hydrolase of the

HD superfamily

(permuted

catalytic motifs)

NO


associated protein

Csm2

CRISPR-associated

protein, TM1810 C-

terminal

NO NO NO


associated protein

Csm6

CRISPR-associated

protein Csm6

CRISPR-associated

protein (Cas_Csm6)

NO NO


associated protein Cas1

CRISPR-associated

protein Cas1

CRISPR associated

protein Cas1

Uncharacterized

ACR

2yzsB-21-253-2e-68


associated protein Cas2

Translation

elongation factor

CRISPR associated

protein Cas2

Uncharacterized

ACR

1zpwX-39-67-7e-13













EFG/EF2, C-

terminal; Virulence-

associated protein D

/ CRISPR

associated protein

Cas2; CRISPR

associated protein

Cas2


Nucleoside

Triphosphate

Hydrolases; Type II

secretory pathway,

component ExeA

(predicted ATPase)

[Intracellular

trafficking and

secretion]

NO AAA domain General

secretion

pathway protein

A

2v1uA-15-43-7e-05

mtb:TBMG_01162 NO NO TFIIB zinc-binding;

putative Helix-turn-

helix domain of

transposase IS66;

HAMP domain

NO NO

mtb:TBMG_01165 NO NO Tautomerase enzyme NO NO

mtb:TBMG_01166 Integrase core domain Integrase, catalytic

core; Ribonuclease

H-like domain

Integrase core domain NO 2q5tA-9-40-7e-04

mtb:TBMG_01170 NO Ribbon-helix-helix;

Vibrio phage ICP1,

Orf50

NO NO 1y9bA-30-68-9e-13

mtb:TBMG_01173 PemK-like protein;

PemK is a growth

inhibitor in E. coli

known to bind to the

promoter region of the

Pem operon, auto-

regulating synthesis.

PemK-like protein;

Plasmid

maintenance

toxin/Cell growth

inhibitor

PemK-like protein Growth inhibitor 1ne8A-31-140-7e-35

mtb:TBMG_01176 NO NO Proteins of 100

residues with WXG

NO NO

mtb:TBMG_01177 Alpha/beta hydrolase NO Alpha/beta hydrolase NO 1tiaA-21-54-7e-10

mtb:TBMG_01179 metallophosphatase

superfamily,

metallophosphatase

domain; Predicted

phosphohydrolases

Metallophosphoeste

rase domain

Calcineurin-like

phosphoesterase

NO 1ii7A-14-46-9e-06










mtb:TBMG_01180 4'-phosphopantetheinyl

transferase superfamily;

Phosphopantetheinyl

transferase component

of siderophore

synthetase [Secondary

metabolites


and catabolism]

Enterobactin

synthetase-like,

component D; 4'-

phosphopantetheiny

l transferase

4'-

phosphopantetheinyl

transferase

superfamily

Phosphopanteth

einyl transferase

component of

siderophore

synthetase

2c43A-18-69-9e-13

mtb:TBMG_01187 CpaE_like, This protein

family consists of

proteins similar to the

cpaE protein of the

Caulobacter pilus

assembly and the orf4

protein of

Actinobacillus pilus

formation gene cluster;

Antiactivator of

flagellar biosynthesis

FleN, an ATPase [Cell

motility]; type VII

secretion AAA-ATPase

EccA

Cobyrinic acid a,c-

diamide synthase;

Tetratricopeptide-

like helical

CobQ/CobB/MinD/Pa

rA nucleotide binding

domain

ATPases

involved in

chromosome

partitioning

1wcv1-23-147-5e-36

mtb:TBMG_01193 2-Nitropropane

dioxygenase (NPD),

one of the nitroalkane

oxidizing enzyme

families, catalyzes

oxidative denitrification

of nitroalkanes to their

corresponding carbonyl

compounds and nitrites;

Nitronate

monooxygenase

2-nitropropane

dioxygenase, NPD;

Aldolase-type TIM

barrel

Nitronate

monooxygenase

Dioxygenases

related to 2-

nitropropane

dioxygenase

3bo9A-25-275-7e-75

mtb:TBMG_01196 START/RHO_alpha_C

/PITP/Bet_v1/CoxG/Ca

lC (SRPBCC) ligand-

binding domain

superfamily

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2d4rA-20-51-7e-08

mtb:TBMG_01197 metal-dependent

hydrolase

NO Predicted metal-

dependent hydrolase

Predicted metal-

dependent

hydrolase

2qzvA-23-36-0.008

mtb:TBMG_01203 NO NO Tetratricopeptide

repeat

NO 2fo7A-31-40-1e-04


FMN reductase

NADPH-dependent

FMN reductase

Multimeric

flavodoxin

WrbA

2arkA-25-95-9e-21

NADPH-dependent

FMN reductase;

mtb:TBMG_01210 Dienelactone

hydrolase

Dienelactone

hydrolase family

Dienelactone

hydrolase and

related enzymes

1zi8A-18-156-5e-39









Dienelactone hydrolase

family;

mtb:TBMG_01213 NO NO NO NO 2fx7H-17-34-0.010

mtb:TBMG_01223 Beta-lactamase-

like; RNA-

metabolising

metallo-beta-

lactamase

Metallo-beta-

lactamase

superfamily; RNA-

metabolising metallo-

beta-lactamase

Predicted

hydrolase of the

metallo-beta-

lactamase

superfamily

3bk2A-37-522-1e-151

Metallo-beta-lactamase

superfamily;

RNA-metabolising

metallo-beta-lactamase;

mRNA degradation

ribonucleases J1/J2

(metallo-beta-lactamase

superfamily)


structure and

biogenesis; Replication,

recombination and

repair]


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-23-140-4e-34


monooxygenase

Antibiotic

biosynthesis

monooxygenase;

Dimeric alpha-beta

barrel

Antibiotic

biosynthesis

monooxygenase

Uncharacterized

ACR

3bm7A-29-75-6e-15


Nucleoside

Triphosphate

Hydrolases; Ftsk

gamma domain; This

domain directs oriented

DNA translocation and

forms a winged helix

structure. Mutated

proteins with

substitutions in the

FtsK gamma DNA-

Cell division

protein

FtsK/SpoIIIE;

DNA translocase

FtsK gamma

FtsK/SpoIIIE family;

Ftsk gamma domain

DNA

segregation

ATPase

FtsK/SpoIIIE

and related

proteins

NO






recognition helix are

impaired in DNA

binding.

mtb:TBMG_01231 PspA/IM30 family;

This family includes

PspA a protein that

suppresses sigma54-

dependent

transcription.

PspA/IM30 PspA/IM30 family NO 2i1kA-15-37-0.003

mtb:TBMG_01233 NO NO YycC-like protein;

Gallidermin

NO NO


2 (NTF2-like)

superfamily.

Limonene-1,2-

epoxide hydrolase

Limonene-1,2-epoxide

hydrolase catalytic

domain

NO 2bngC-100-174-5e-45

mtb:TBMG_01237 Glycosyltransferases

catalyze the transfer of

sugar moieties from

activated donor

molecules to specific

acceptor molecules,

forming glycosidic

bonds; Glycosyl

transferases, related to

UDP-

glucuronosyltransferase


and metabolism /

Signal transduction

mechanisms]

UDP-

glucuronosyl/UDP-

glucosyltransferase;

Glycosyl

transferase, family

28, C-terminal

Glycosyltransferase

family 28 C-terminal

domain

Glycosyl

transferases,

related to UDP-

glucuronosyltran

sferase

1rrvA-22-143-5e-35

mtb:TBMG_01238 FhuF 2Fe-2S C-

terminal domain; This

family consists of

several bacterial ferric

iron reductase protein

(FhuF) sequences.

Ferric iron

reductase, C-

terminal

FhuF 2Fe-2S C-

terminal domain

NO NO

mtb:TBMG_01241 Phage protein

Gp37/Gp68;

Homologues of phage

proteins Gp37 and

Gp68 are found in

several bacteria.

Burkholderia phage

phiE125, Gp37

Phage protein

Gp37/Gp68

NO NO

mtb:TBMG_01244 NO NO NO NO 1z5hA-8-38-0.003

mtb:TBMG_01246 NO NO Multidrug resistance

efflux transporter

NO NO

mtb:TBMG_01247 Subunit B of Class III

Extradiol ring-cleavage

dioxygenases

NO NO NO NO

mtb:TBMG_01252 Integral membrane

protein TerC family

Integral membrane

protein TerC,

riboswitch-linked

Integral membrane

protein TerC family

Membrane

protein TerC,

possibly

involved in

tellurium

resistance

NO











mtb:TBMG_01253 LGFP repeat; protein

potentially involved in

peptidoglycan

biosynthesis [Cell


outer membrane]

LGFP LGFP repeat NO 2pziA-10-34-8e-04

mtb:TBMG_01255 Lysin domain, found in

a variety of enzymes

involved in bacterial

cell wall degradation.

This domain may have

a general peptidoglycan

binding function.

Peptidoglycan-

binding lysin

domain

LysM domain NO NO

mtb:TBMG_01257 nitrobindin heme-

binding domain;

Nitrobindin is a heme-

containing lipocalin

that may reversibly

bind nitric oxide.

Calycin-like NO NO 2fr2A-100-227-8e-61

mtb:TBMG_01258 Diaminopimelate

epimerase;Phenazine

biosynthesis-like

protein

Phenazine

biosynthesis

PhzC/PhzF protein

Phenazine

biosynthesis-like

protein

Predicted

epimerase,

PhzC/PhzF

homolog

1xubA-23-170-2e-43

mtb:TBMG_01260 PAC2 family; This

PAC2 (Proteasome

assembly chaperone)

family of proteins is

found in bacteria,

archaea and eukaryotes.

Transcription factor

IIA, alpha subunit,

N-terminal;

Proteasome

assembly chaperone

2

PAC2 family NO 2p90B-45-322-6e-89

mtb:TBMG_01266 NO NO Adenylate kinase,

active site lid

NO NO

mtb:TBMG_01267 Ribonuclease BN-like

family

NO Virulence factor BrkB Predicted

multitransmemb

rane protein

no


BCR

2o0qA-30-125-2e-30

mtb:TBMG_01269 YjgF_YER057c_UK11

4_like_6 , This group

of proteins belong to a

large family of

YjgF/YER057c/UK114

-like proteins present in

bacteria, archaea, and

eukaryotes

YjgF/Yer057p/UK1

14 family;

Endoribonuclease

L-PSP/chorismate

mutase-like

Endoribonuclease L-

PSP

Putative

translation

initiation

inhibitor

2ig8B-25-123-2e-29

mtb:TBMG_01274 NO NO Putative GTPase

activating protein for

Arf

NO NO











mtb:TBMG_01277 NO NO Chromatin protein

Cren7

NO NO

mtb:TBMG_01278 NO NO Alpha/beta hydrolase

family

NO 1q0rA-20-55-1e-08

mtb:TBMG_01279 RecG_wedge_OBF: A

subfamily of OB folds

corresponding to the

OB fold found in the

N-terminal (wedge)

domain of Escherichia

coli RecG.

Nucleic acid

binding protein,

Rv2694c

OB-fold nucleic acid

binding domain

NO 1gm5A-28-43-4e-05

mtb:TBMG_01283 Amino acid

transporters [Amino

acid transport and

metabolism]

Amino

acid/polyamine

transporter I

Amino acid permease Amino acid

transporters

2vl7A-11-33-0.002


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I;

TRAM domain; SAM-

dependent

methyltransferases

related to tRNA (uracil-

5-)-methyltransferase


structure and

biogenesis]

Deoxyribonuclease/

rho motif-related

TRAM; (Uracil-5)-

methyltransferase;

Nucleic acid-

binding, OB-fold-

like

TRAM domain;

Protein-L-

isoaspartate(D-

aspartate) O-

methyltransferase

(PCMT)

SAM-dependent

methyltransferas

es related to

tRNA (uracil-5-

)-

methyltransferas

e

1uwvA-19-352-6e-98

mtb:TBMG_01286 NO NO ABC-2 family

transporter protein;


family group 2

NO NO

mtb:TBMG_01288 Permease P (pink-eyed

dilution); Na+/H+

antiporter NhaD and

related arsenite

permeases [Inorganic

ion transport and

metabolism]

Arsenical pump

membrane protein,

ArsB; Divalent ion

symporter

Citrate transporter Na+/H+

antiporter NhaD

and related

arsenite

permeases

NO

mtb:TBMG_01289 Permease P (pink-eyed

dilution); Na+/H+

antiporter NhaD and

related arsenite

permeases [Inorganic

ion transport and

metabolism]

Arsenical pump

membrane protein,

ArsB; Divalent ion

symporter

Citrate transporter Na+/H+

antiporter NhaD

and related

arsenite

permeases

NO

mtb:TBMG_01290 The CBS domain,

named after human

CBS, is a small domain

originally identified in

cystathionine beta-

synthase and is

subsequently found in a

wide range of different

proteins.

Cystathionine beta-

synthase, core;

Aldolase-type TIM

barrel

CBS domain CBS domains 3ddjA-16-83-2e-17










mtb:TBMG_01292 DEDDy 3'-5'

exonuclease domain of

Ribonuclease D and

similar proteins;

Ribonuclease D


structure and

biogenesis]

Helicase/RNase D

C-terminal, HRDC

domain; 3'-5'

exonuclease

domain;HRDC-like;

Ribonuclease H-like

domain

3'-5' exonuclease ;

HRDC domain

Ribonuclease D 3cymA-34-253-4e-68

mtb:TBMG_01293 NO NO Bacteriophage lambda

minor tail protein

(GpG)

NO NO

mtb:TBMG_01297 Chlorite dismutase;

This family contains

chlorite dismutase

enzymes of bacterial

and archaeal origin.

Chlorite dismutase;

Dimeric alpha-beta

barrel

Chlorite dismutase Uncharacterized

ACR

1vdhA-21-258-1e-69


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

3bkwA-14-102-8e-23

mtb:TBMG_01302 Dihydrofolate reductase

(DHFR).

Bacterial

bifunctional

deaminase-

reductase, C-

terminal;

Dihydrofolate

reductase-like

domain

RibD C-terminal

domain

Pyrimidine

reductase,

riboflavin

biosynthesis

2b3zD-19-223-1e-59

mtb:TBMG_01303 AFG1-like ATPase ATPase, AFG1-like AFG1-like ATPase Predicted

ATPase

NO


superfamily; ribosomal-

protein-alanine

acetyltransferase

GCN5-related N-

acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) family

Histone

acetyltransferase

HPA2 and

related

acetyltransferase

s

1tiqA-22-166-1e-42

mtb:TBMG_01305 NO Twin-arginine

translocation

pathway, signal

sequence

Ubiquitinol-

cytochrome C

reductase Fe-S subunit

TAT signal

NO NO

mtb:TBMG_01308 NO NO Helix-turn-helix

domain of transposase

family ISL3

NO NO

mtb:TBMG_01309 NO NO Beta-ketoacyl

synthase, N-terminal

domain ;

Homeodomain-like

domain

NO NO

mtb:TBMG_01324 ParB-like nuclease

domain; ParB-like

partition proteins

ParB-like nuclease ParB-like nuclease

domain

Predicted

transcriptional

regulators

1vz0B-22-52-7e-08

mtb:TBMG_01326 NO NO NO NO 2vanA-47-36-0.002

mtb:TBMG_01327 NO NO Periplasmic binding

protein-like domain

NO NO

mtb:TBMG_01328 Low molecular weight Bile acid:sodium Sodium Bile acid Arsenite efflux 1jf8A-34-170-5e-43















phosphatase family;

Membrane transport

protein; Low molecular

weight phosphotyrosine

protein phosphatase

symporter;

Arsenical-resistance

protein ACR3;

Phosphotyrosine

protein phosphatase

I superfamily

symporter family ;

Low molecular weight

phosphotyrosine

protein phosphatase

pump ACR3 and

related

permeases

mtb:TBMG_01332 NO NO MerC mercury

resistance protein;

7TM diverse

intracellular signalling

Uncharacterized

BCR

NO






sigma factors by

phosphorylation

Sulphate


a-factor antagonist

STAS; Anti-sigma

factor antagonist

STAS domain NO 1th8B-17-123-1e-29


Golgi protein; This is a

family of SNARE

associated Golgi

proteins. The yeast

member of this family

localises with the t-

SNARE Tlg2.

SNARE associated

Golgi protein

SNARE associated

Golgi protein

Uncharacterized

membrane-

associated

protein

NO

mtb:TBMG_01335 Chloramphenicol (Cm)

phosphotransferase

(CPT). Cm-inactivating

enzyme

Chloramphenicol

phosphotransferase-

like

Chloramphenicol

phosphotransferase-

like protein

NO 1x6vB-16-45-2e-05

mtb:TBMG_01338 NO Haemerythrin/HHE

cation-binding

motif

Hemerythrin HHE

cation binding domain

NO 2p0nA-16-49-5e-07

mtb:TBMG_01339 NO NO NO NO 2fggA-100-118-2e-28

mtb:TBMG_01340 Crotonase/Enoyl-

Coenzyme A (CoA)

hydratase superfamily;

NO NO Uncharacterized

ACR

1uc2A-52-568-1e-163

mtb:TBMG_01341 Archease protein

family

Archease domain Archease protein

family

NO 1jw3A-19-152-3e-38

mtb:TBMG_01342 peptide chain release

factor 1; Provisional

NO eRF1 domain 3 Peptide chain

release factor

Erf1

1dt9A-16-140-8e-34

mtb:TBMG_01343 peptide chain release

factor 1; Provisional

NO eRF1 domain 3 Peptide chain

release factor

Erf1

1dt9A-16-140-8e-34

mtb:TBMG_01344 NO NO Alpha/beta hydrolase

family

NO 2z3zA-14-70-7e-13

mtb:TBMG_01345 CBS domain Cystathionine beta-

synthase, core;

CBS domain CBS domains 1y5hA-100-130-7e-32












Aldolase-type TIM

barrel

mtb:TBMG_01346 SpoIVFB Site-2

protease (S2P), a zinc

metalloprotease

(MEROPS family

M50B), regulates

intramembrane

proteolysis (RIP), and

is involved in the pro-

sigmaK pathway of

bacterial spore

formation;

CBS_pair_SpoIVFB_E

riC_assoc

Cystathionine beta-

synthase, core;

Peptidase M50

Peptidase family M50

; CBS domain

Zn-dependent

proteases

3b4rA-24-129-1e-30

mtb:TBMG_01347 Usp: Universal stress

protein family; Adenine

nucleotide alpha

hydrolases superfamily

including N type ATP

PPases, ATP

sulphurylases Universal

Stress Response protein

and electron transfer

flavoprotein (ETF).

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-27-172-7e-44


protein family.

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-90-210-3e-55

mtb:TBMG_01352 Cupin domain; This

family represents the

conserved barrel

domain of the 'cupin'

superfamily

Cupin, RmlC-type;


fold

Cupin domain Uncharacterized

ACR, double-

stranded beta-

helix domain

3d82A-17-39-4e-04


domains;


[Transcription]

Winged helix-turn-

helix transcription

repressor DNA-

binding

Helix-turn-helix

domain

NO 1i1gA-13-46-4e-06

mtb:TBMG_01354 NO NO DoxX NO NO

mtb:TBMG_01358 FHIT (fragile histidine

family): FHIT proteins,

related to the HIT

family carry a motif

HxHxH/Qxx (x, is a

hydrophobic amino

acid)

Histidine triad

(HIT) protein


tetraphosphate

(Ap4A)

hydrolase and

other HIT

family

hydrolases

1z84A-13-119-4e-28

mtb:TBMG_01362 Nudix_Hydrolase_26; NUDIX hydrolase

domain

NUDIX domain NO 1vcdA-25-75-2e-14

mtb:TBMG_01368 NO Integrase, N-

terminal zinc-

binding domain-like

Transcriptional

regulator

Uncharacterized

ACR

1konA-45-329-2e-91

mtb:TBMG_01372 NO NO Beta-ketoacyl


NO NO











domain

mtb:TBMG_01395 DNA repair photolyase

[DNA replication,

recombination, and

repair]

Elongator protein

3/MiaB/NifB;

Radical SAM

Radical SAM

superfamily

DNA repair

photolyase

1tv8A-14-37-0.005

mtb:TBMG_01396 metallophosphatase

superfamily,

metallophosphatase

domain;

phosphohydrolases;

Phosphodiesterase/alkal

ine phosphatase D


and metabolism]

Metallophosphoeste

rase domain; Twin-

arginine

translocation

pathway, signal

sequence; Purple

acid phosphatase-

like, N-terminal

Calcineurin-like

phosphoesterase

NO 1xzwB-19-185-2e-49

mtb:TBMG_01398 Putative neutral zinc

metallopeptidase

zinc

metallopeptidase

putative

Putative neutral zinc

metallopeptidase

Predicted

metalloprotease

NO


(PYR1), PYR1-like

(PYL), regulatory


acid receptors


proteins

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2ns9A-17-60-2e-10

mtb:TBMG_01402 membrane protein NO Fusaric acid resistance

protein-like

NO 2a01A-17-37-0.005

mtb:TBMG_01403 NO NO NO NO 2a1vA-20-36-0.003

mtb:TBMG_01404 Bacterial

transglutaminase-like

N-terminal region;


enzymes, putative

cysteine proteases


and metabolism]

Bacterial

transglutaminase-

like, N-terminal

Bacterial


N-terminal region ;


superfamily

Transglutaminas

e-like enzymes,

putative cysteine

proteases

2q3zA-19-96-1e-20

mtb:TBMG_01405 NO NO zinc-ribbon domain NO NO

mtb:TBMG_01406 NO NO A circularly permuted

ATPgrasp ; A

predicted alpha-helical

domain with a

conserved ER motif.

Uncharacterized

BCR

NO

mtb:TBMG_01407 Putative amidoligase

enzyme; Bacterial


N-terminal region;

Bacterial

transglutaminase-

like, N-terminal

Bacterial


N-terminal region ;


superfamily ; Putative

amidoligase enzyme

Transglutaminas

e-like enzymes,

putative cysteine

proteases

NO

mtb:TBMG_01408 Patatin-like

phospholipase domain

containing protein 6,

protein 7, and fungal

NTE1; effector domain

of the CAP family of

transcription factors

Cyclic nucleotide-

binding domain;

Lysophospholipase

patatin, conserved

site;

Patatin/Phospholipa

se A2-related;


Cyclic nucleotide-

binding domain;

Patatin-like

phospholipase

Predicted

esterase of the

alpha-beta

hydrolase

superfamily

1oxwC-16-131-4e-33












fold;

mtb:TBMG_01410 MacB-like periplasmic

core domain

Permease FtsX-like MacB-like

periplasmic core

domain ; FtsX-like

permease family

NO NO

mtb:TBMG_01412 NO NO integral membrane

protein

NO NO

mtb:TBMG_01414 NO Dimeric alpha-beta

barrel

Antibiotic

biosynthesis

monooxygenase

NO NO

mtb:TBMG_01415 NO Dimeric alpha-beta

barrel

Antibiotic

biosynthesis

monooxygenase

NO 1iujB-19-37-0.004

mtb:TBMG_01416 NO NO NO NO 2p6hA-33-117-1e-27

mtb:TBMG_01419 proteins similar to

Escherichia coli yceG

YceG-like YceG-like family Predicted

periplasmic

solute-binding

protein

2r1fA-21-269-5e-73

mtb:TBMG_01421 Type IV leader

peptidase family

Prepilin type IV

endopeptidase,

peptidase domain

Type IV leader

peptidase family

NO NO

mtb:TBMG_01424 NO NO Adenylate cyclase

associated (CAP) N

terminal ;

Tropomyosin like;

Basic region leucine

zipper; CorA-like

Mg2+ transporter

protein; Fusaric acid

resistance protein

family; Phage capsid

scaffolding protein

(GPO) serine

peptidase

NO NO

mtb:TBMG_01431 Alpha/beta hydrolase NO Alpha/beta hydrolase NO NO

mtb:TBMG_01432 NO ESX-1 secretion-

associated protein

EspC

NO NO 1wa8A-22-36-0-005











mtb:TBMG_01437 NO NO Silicon transporter;

Oligosaccharyl

transferase STT3

subunit

NO NO

mtb:TBMG_01444 ERCC4 domain; This

domain is a family of

nucleases; Lsr2; Lsr2 is

a small, basic DNA-

bridging protein present

in Mycobacterium and

related actinomycetes

ERCC4 domain;

Restriction

endonuclease, type

II-like; DNA repair

nuclease, XPF-

type/Helicase; Lsr2

Lsr2 NO 2bgwA-18-114-2e-26

mtb:TBMG_01447 Endo-N-

acetylmuramidases

(muramidases) are

lysozymes (also

referred to as

peptidoglycan

hydrolases) that

degrade bacterial cell

walls by catalyzing the

hydrolysis of 1,4-beta-

linkages between N-

acetylmuramic acid and

N-acetyl-D-

glucosamine residues.

Twin-arginine

translocation

pathway, signal

sequence

TAT (twin-arginine

translocation) pathway

signal sequence

NO 1sfsA-16-58-2e-09

mtb:TBMG_01450 M20 Dipeptidases;

Peptidase M20 family,

dipeptidase-like

subfamily;

Acetylornithine

deacetylase/Succinyl-

diaminopimelate

desuccinylase and

related deacylases


and metabolism]

Peptidase M20,

dimerisation

Peptidase family

M20/M25/M40;

Peptidase dimerisation

domain

Acetylornithine

deacetylase/Suc

cinyl-

diaminopimelate

desuccinylase

and related

deacylases

2zogA-26-441-1e-124

mtb:TBMG_01455 NO NO Sigma-70, region 4 NO 1s7oC-65-37-0.005

mtb:TBMG_01456 Helix-turn-helix XRE-

family like proteins.

Prokaryotic DNA

binding proteins

belonging to the

xenobiotic response

element family of

transcriptional

regulators;

Helix-turn-helix

type 3; Lambda

repressor-like,

DNA-binding

Helix-turn-helix

domain

Predicted Zn

peptidase

1y9qA-26-63-7e-11

mtb:TBMG_01457 PIN (PilT N terminus)

domain: Superfamily;

PIN_SF The PIN (PilT

N terminus) domain

belongs to a large

nuclease superfamily

with representatives

from eukaryota,

eubacteria, and archaea.

NO NO NO 2h1cA-18-42-6e-05

mtb:TBMG_01463 Permeases of the major

facilitator superfamily

Major facilitator

superfamily

domain, general

substrate

Vacuole effluxer

Atg22 like

Permeases of the

major facilitator

superfamily

1pw4A-14-81-3e-16









transporter;

Autophagy-related

protein 22-like

mtb:TBMG_01464 NO Mycobacterium

membrane

Mycobacterium

membrane protein

NO NO

mtb:TBMG_01481 lysine decarboxylase NO DNA recombination-

mediator protein A

Predicted

Rossmann fold

nucleotide-

binding protein

1wekA-25-137-1e-33


Acyl-CoA

acyltransferase domain

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 2jgpA-12-89-1e-18

mtb:TBMG_01495 SSB_OBF: A

subfamily of OB folds

similar to the OB fold

of ssDNA-binding

protein (SSB).

Primosome

PriB/single-strand

DNA-binding;

Single-strand DNA-

binding; Nucleic

acid-binding, OB-

fold

Single-strand binding

protein family

Single-stranded

DNA-binding

protein

1qvcA-19-90-3e-19


thioesterase (4HBT)

NO Thioesterase-like

superfamily

Predicted

thioesterase

1njkA-23-93-4e-20

mtb:TBMG_01500 NO NO Anti-sigma-K factor

rskA; HemX; Heavy-

metal resistance

NO NO

mtb:TBMG_01504 HNH nucleases; HNH

endonuclease signature

which is found in viral,

prokaryotic, and


HNH endonuclease;

HNH nuclease

HNH endonuclease Restriction

endonuclease

2qgpB-29-92-2e-19

mtb:TBMG_01505 NO NO Repair protein NO NO


Oxidoreductases and


Thioredoxin fold;

DSBA-like thioredoxin

domain

DSBA-like

thioredoxin domain;

Thioredoxin-like

fold

DSBA-like

thioredoxin domain

NO 2imfA-13-94-2e-20

mtb:TBMG_01529 Sodium:dicarboxylate

symporter family;

Na+/H+-dicarboxylate

symporters [Energy

production and

conversion]

Sodium:dicarboxyla

te symporter

Sodium:dicarboxylate

symporter family

Na+/H+-

dicarboxylate

symporters

2nwlC-28-326-6e-90

mtb:TBMG_01535 Phospholipid

methyltransferase

Isoprenylcysteine

carboxyl

methyltransferase

Phospholipid

methyltransferase

Putative protein-

S-

isoprenylcystein

e

methyltransferas

e

NO













CAP family of

transcription factors;


channel

Cyclic nucleotide-

binding domain;

Mechanosensitive

ion channel MscS;

Like-Sm

ribonucleoprotein

(LSM)-related

domain;

Mechanosensitive

ion channel MscS,

transmembrane-2;


fold; Cyclic

nucleotide-binding-

like


channel; Cyclic

nucleotide-binding

domain

Small-

conductance

mechanosensitiv

e channel

2oauA-14-224-3e-59



variety of cellular

Activities)

ATPase, AAA+

type, core; ATPase,

dynein-related,

AAA domain

AAA domain (dynein-

related subfamily)

MoxR-like

ATPases

3cf0A-17-87-5e-18

mtb:TBMG_01549 Protein containing von

Willebrand factor type

A (vWA) domain [

CoxE-like VWA domain

containing CoxE-like

protein

Von Willebrand

A-domain-

containing

protein

1yvrA-12-39-0.003


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I


domain

SAM-dependent

methyltransferas

es

3d2lC-17-123-4e-29

mtb:TBMG_01554 Oligomerisation

domain

Ribosome-

associated, Iojap-

like

Oligomerisation

domain

Uncharacterized

ACR (homolog

of plant Iojap

proteins)

2o5aA-34-135-3e-33

mtb:TBMG_01556 SGNH_hydrolase, or

GDSL_hydrolase, is a

diverse family of

lipases and esterases.

Esterase, SGNH

hydrolase-type

GDSL-like

Lipase/Acylhydrolase

family

NO 2o14A-12-47-7e-06

mtb:TBMG_01557 DegV family, The

structure of this protein

revealed a bound fatty-

acid molecule in a

pocket between the two

protein domains

DegV DegV family;

Hexokinase

Uncharacterized

BCR

2dt8A-31-280-2e-76


superfamily: Predicted

acetyltransferase

involved in intracellular

survival and related

acetyltransferases

GCN5-related N-

acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain;

Sterol carrier protein

domain

Histone

acetyltransferase

HPA2 and

related

acetyltransferase

s

2ozgA-21-289-7e-79




apyrimidinic site)


glycosidases (Alka-


glycosidases; Helix-

hairpin-helix motif;

The HhH domain is a

short DNA-binding

domain.

Helix-hairpin-helix

DNA-binding

motif, class 1;

Competence protein

ComEA, helix-

hairpin-helix

domain; RuvA

domain 2-like;

Soluble ligand

binding domain

SLBB domain; Helix-

hairpin-helix motif

DNA uptake

protein and

related DNA-

binding proteins

3bzcA-20-229-6e-61










mtb:TBMG_01560 Competence protein;

Predicted membrane

metal-binding protein

ComEC/Rec2-

related protein

Competence protein Predicted

multitransmemb

rane, metal-

binding protein

1rh1A-16-32-0.002

mtb:TBMG_01561 NO DNA polymerase

III, clamp loader

complex,

gamma/delta/delta

subunit, C-terminal;

DNA polymerase III,

delta subunit

NO 1jr3D-15-144-4e-35

mtb:TBMG_01563 A circularly permuted

ATPgrasp

NO A circularly permuted

ATPgrasp

Uncharacterized

BCR

2io8A-15-119-2e-29

mtb:TBMG_01564 A predicted alpha-

helical domain with a

conserved ER motif

NO A predicted alpha-

helical domain with a

conserved ER motif.

Uncharacterized

BCR

NO


superfamily; Bacterial


N-terminal region

Bacterial

transglutaminase-

like, N-terminal

Bacterial


N-terminal region;


superfamily

Transglutaminas

e-like enzymes,

putative cysteine

proteases

1x3zA-12-94-5e-20

mtb:TBMG_01568 The CBS domain,

named after human

CBS, is a small domain

originally identified in

cystathionine beta-

synthase and is

subsequently found in a

wide range of different

proteins.

Cystathionine beta-

synthase, core;

Aldolase-type TIM

barrel

CBS domain CBS domains 2rc3C-40-127-6e-31

mtb:TBMG_01569 PemK-like protein;

PemK is a growth

inhibitor in E. coli

known to bind to the

promoter region of the

Pem operon, auto-

regulating synthesis.

PemK-like protein;

Plasmid

maintenance

toxin/Cell growth

inhibitor

PemK-like protein NO 1ne8A-19-51-2e-07

mtb:TBMG_01572 Glycosyl hydrolases

family 15;

Glucoamylase and

related glycosyl

hydrolases


and metabolism]

Six-hairpin

glycosidase-like;

Glycoside hydrolase

family 15

Glycosyl hydrolases

family 15

Uncharacterized

ACR

1ulvA-13-321-2e-90



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs.

Binding-protein-

dependent transport

systems inner

membrane

component;

Sulphate ABC

transporter,

permease protein

CysT

Binding-protein-

dependent transport

system inner

membrane component

ABC-type

sulfate/molybdat

e transport

systems,

permease

components

2onkC-27-196-4e-51












Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs.

Binding-protein-

dependent transport

systems inner

membrane

component;

Sulphate ABC

transporter,

permease protein

CysT

Binding-protein-

dependent transport

system inner

membrane component

ABC-type

sulfate/molybdat

e transport

systems,

permease

components

2onkC-25-201-2e-52

mtb:TBMG_01580 OPT oligopeptide

transporter protein;

Oligopeptide

transporter OPT

superfamily

OPT oligopeptide

transporter protein

Uncharacterized

membrane

protein

1ciiA-29-34-8e-04

mtb:TBMG_01582 Sirohydrochlorin cobalt

chelatase (CbiX) and

sirohydrochlorin iron

chelatase (SirB), C-

terminal domain. SirB

catalyzes the ferro-

chelation of

sirohydrochlorin to

siroheme, the prosthetic

group of sulfite and

nitrite reductases.

Cobalamin (vitamin

B12) biosynthesis

CbiX

CbiX Uncharacterized

ACR

2jh3A-21-104-2e-23

mtb:TBMG_01585 NO NO 4Fe-4S binding

domain

NO NO


permease

NO

mtb:TBMG_01598 MbtH-like protein; This

domain is found in the

MbtH protein, as well

as at the N terminus of

the antibiotic synthesis

protein NIKP1.

MbtH-like protein MbtH-like protein Uncharacterized

BCR

2gpfA-44-126-8e-31

mtb:TBMG_01605 Regulator of polyketide

synthase expression

[Signal transduction

mechanisms /

Secondary metabolites


and catabolism]

NO PucR C-terminal

helix-turn-helix

domain

NO NO

mtb:TBMG_01609 This cd contains two

tandem repeats of the

cystathionine beta-

synthase (CBS pair)

domains associated

with the CorC_HlyC

domain; Transporter

associated domain;

Hemolysins and related

proteins containing

CBS domains

Cystathionine beta-

synthase, core;

Transporter-

associated domain;

CO dehydrogenase

flavoprotein-like,

FAD-binding,

subdomain 2

CBS domain;

Transporter associated

domain

Hemolysins and

related proteins

containing CBS

domains

1pvmB-12-61-9e-10

mtb:TBMG_01610 NO NO NO NO 2z3gB-19-49-4e-07



regulator

NO NO












residues with WXG

Type VII secretion

system ESAT-6-like

Proteins of 100

residues with WXG

NO 1wa8A-19-36-0.002


residues with WXG

Type VII secretion

system ESAT-6-like

Proteins of 100

residues with WXG

NO NO

mtb:TBMG_01630 NO NO Polymorphic PE/PPE

proteins C terminal

NO 1jhnA-30-34-0.004

mtb:TBMG_01633 Repair protein NO Repair protein Methyl-

accepting

chemotaxis

protein

1tr2B-17-49-3e-06

mtb:TBMG_01636 NO NO Iron-containing outer

mitochondrial

membrane protein N-

terminus

NO NO

mtb:TBMG_01640 Superfamily of

activating enzymes

(E1) of the ubiquitin-

like proteins

UBA/THIF-type

NAD/FAD binding

fold; Molybdenum

cofactor

biosynthesis,

MoeB; NAD(P)-

binding domain

ThiF family Dinucleotide-

utilizing

enzymes

involved in

molybdopterin

and thiamine

biosynthesis

family 2

1zud3-21-138-2e-33

mtb:TBMG_01641 NO NO Cobalamin synthesis

protein cobW C-

terminal domain

NO 2b67A-34-52-1e-07

mtb:TBMG_01647 Ferredoxin reductase

(FNR), an FAD and

NAD(P) binding

protein

NO NO Sulfite reductase

flavoprotein

subunit

1ddgA-24-169-2e-43

mtb:TBMG_01648 Molybdopterin-Binding

(MopB) domain of the

MopB superfamily of

proteins; sulfite

reductase [NADPH]

flavoprotein, alpha-

component;

NO NO Anaerobic

dehydrogenases,

typically

selenocysteine-

containing

2nyaA-17-54-8e-09


domains;

helix_turn_helix

multiple antibiotic

resistance protein;

Transcription

regulator HTH,

MarR-type; Winged

helix-turn-helix

transcription

repressor DNA-

binding

MarR family Transcriptional

regulators

2a61A-26-118-4e-28

mtb:TBMG_01654 Cobalt transport

protein;

ABC/ECF

transporter,

transmembrane

component

Cobalt transport

protein

ABC-type

cobalt transport

system,

permease

component

CbiQ and

related

transporters

NO












mtb:TBMG_01656 Amidinotransferase; N-

Dimethylarginine

dimethylaminohydrolas

e [Amino acid transport

and metabolism]

Amidinotransferase Amidinotransferase N-

Dimethylarginin

e

dimethylaminoh

ydrolase

2aafB-17-140-4e-34

mtb:TBMG_01659 Spore germination

protein; amino acid

transporter;

Amino

acid/polyamine

transporter I;

Amino acid

permease domain


transporters

NO

mtb:TBMG_01660 Adenine nucleotide

alpha hydrolases

superfamily including

N type ATP PPases,

ATP sulphurylases

Universal Stress

Response protein and

electron transfer

flavoprotein (ETF);

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold;

UspA

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-18-91-4e-19



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters;

ABC-type sugar

transport system,

permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component




Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters;

ABC-type sugar

transport system,

permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

ABC-type sugar

transport

systems,

permease

components

2r6gF-23-253-4e-68

mtb:TBMG_01664 Predicted Zn-dependent

proteases and their

inactivated homologs;

Putative modulator of

DNA gyrase

Peptidase U62,

modulator of DNA

gyrase


DNA gyrase

Predicted Zn-

dependent

proteases and

their inactivated

homologs

1vpbA-16-263-7e-73

mtb:TBMG_01665 Predicted Zn-dependent

proteases and their

inactivated homologs;


DNA gyrase

Peptidase U62,

modulator of DNA

gyrase


DNA gyrase

Predicted Zn-

dependent

proteases and

their inactivated

homologs

1vpbA-14-267-2e-72

mtb:TBMG_01666 NO NO Carboxymuconolacton

e decarboxylase

family

Uncharacterized

ACR

2oyoA-21-107-2e-24

mtb:TBMG_01668 ATP-dependent

exoDNAse

(exonuclease V), alpha

subunit - helicase

superfamily I member

[DNA replication,

recombination, and

repair]

NO Family description ATP-dependent

exoDNAse

(exonuclease V),

alpha subunit -

helicase

superfamily I

member

1w36D-18-42-1e-04

mtb:TBMG_01674 Transposase and Homeodomain-like; Helix-turn-helix NO 2ga1A-25-51-3e-07











inactivated derivatives

[DNA replication,

recombination, and

repair]

Winged helix-turn-

helix transcription

repressor DNA-

binding

domain


(includes fungal


etc.) These enzymes act

on carboxylic esters;

Alpha/beta hydrolase

family;


family

Hydrolases of

the alpha/beta

superfamily

2jbwB-16-90-3e-19

mtb:TBMG_01679 protein containing a

NRPS condensation

(elongation) domain

Condensation

domain

Condensation domain NO 2jgpA-13-245-1e-65

mtb:TBMG_01681 NO Plasmid

maintenance

toxin/Cell growth

inhibitor

Alpha-lytic protease

prodomain

NO 2a7yA-100-106-1e-24


superfamily;

Beta-lactamase-like Metallo-beta-

lactamase superfamily

Zn-dependent

hydrolases,

including

glyoxylases

1p9eA-18-161-1e-40

mtb:TBMG_01685 Aldo-keto reductases Aldo/keto

reductase; NADP-

dependent

oxidoreductase

domain

Aldo/keto reductase

family

Predicted

oxidoreductases

(related to aryl-

alcohol

dehydrogenases)

1pz1A-27-357-2e-99

mtb:TBMG_01690 Phosphorylase

superfamily

Nucleoside

phosphorylase

domain

Phosphorylase

superfamily

Nucleoside

phosphorylase

3bl6A-20-151-8e-38

mtb:TBMG_01691 Phosphorylase

superfamily

Nucleoside

phosphorylase

domain

Phosphorylase

superfamily

NO 1zosA -30- 59- 3e-10


Oxidoreductases and


Thioredoxin fold;

DSBA-like thioredoxin

domain

DSBA-like

thioredoxin domain

DSBA-like

thioredoxin domain

NO 1bedA-19-61-3e-10


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 1l5aA-14-44-5e-05

mtb:TBMG_01709 NO NO 2-keto-3-

deoxygluconate

permease

NO NO

mtb:TBMG_01710 NO NO SdpI/YhfL protein

family;

Exopolysaccharide

synthesis, ExoD

NO NO

mtb:TBMG_01715 Sulfotransferase family; Sulfotransferase

domain

Sulfotransferase

family

NO 1fmjA-16-69-9e-13

mtb:TBMG_01717 Major Facilitator

Superfamily;

Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

1pw4A-14-98-2e-21

mtb:TBMG_01718 Molecular chaperone

[Posttranslational



Heat shock protein

Hsp70

Hsp70 protein Molecular

chaperone

2v7yA-18-659-0.0


superfamily;



Zn-dependent

hydrolases,

1xm8A-26-204-8e-54
















including

glyoxylases



domain

Beta-


dase-like

Beta-lactamase Beta-lactamase

class C and

other penicillin

binding proteins

1ci9A-20-146-4e-36

mtb:TBMG_01726 NO Lysine-type

exporter protein

(LYSE/YGGA)

LysE type translocator NO NO


nucleases including

Short Patch Repair

(Vsr) Endonucleases,

archaeal Holliday

junction resolvases,

MutH methy-directed

DNA mismatch-repair

endonucleases, and

catalytic domains of

many restriction

endonucleases, such as

EcoRI, BamHI, and

FokI

Restriction

endonuclease, type

II-like

NO NO 1cw0A-18-39-0.001


domains; Regulator of

polyketide synthase

expression [Signal

transduction

mechanisms /



and catabolism]

NO PucR C-terminal

helix-turn-helix

domain

Regulator of

polyketide

synthase

expression

NO

mtb:TBMG_01740 NO NO CT1975-like protein NO NO

mtb:TBMG_01741 NO NO Histidine kinase-like

ATPase domain

NO NO

mtb:TBMG_01745 SURF1 superfamily.

Surf1/Shy1 has been

implicated in the

posttranslational steps

of the biogenesis of the

mitochondrially-

encoded Cox1 subunit

of cytochrome c

oxidase (complex IV).

Surfeit locus 1 SURF1 family Uncharacterized

ACR

NO

mtb:TBMG_01747 Haloacid dehalogenase-

like hydrolases;

phosphatases

Haloacid

dehalogenase-like

hydrolase

Haloacid

dehalogenase-like

hydrolase

Predicted

phosphatases

2ah5A-28-186-5e-48

mtb:TBMG_01749 Aspartate

aminotransferase

family

Aminotransferases,

class-I, pyridoxal-

phosphate-binding

site;

Aminotransferase,

class I/classII;

Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain

1; subdomain 2;

Pyridoxal

phosphate-

dependent

transferase, major

domain

Aminotransferase

class I and II

Histidinol-

phosphate

aminotransferas

e/Tyrosine

aminotransferas

e

2douA-22-171-1e-43










mtb:TBMG_01750 NIF3 (NGG1p

interacting factor 3)

NGG1p interacting

factor 3, NIF3

NIF3 (NGG1p

interacting factor 3)

Uncharacterized

ACR

2gx8C-32-283-7e-77

mtb:TBMG_01751 Putative zinc ribbon

domain; Structural

modelling suggests this

domain may bind

nucleic acids; Zn-

ribbon protein, possibly

nucleic acid-binding

NO Putative zinc ribbon

domain

NO 2i1jA-17-36-0.005

mtb:TBMG_01753 2OG-Fe(II) oxygenase

superfamily;

NO NO NO NO

mtb:TBMG_01754 CYTH-like (also

known as triphosphate

tunnel metalloenzyme

(TTM)-like)

Phosphatases; CHAD

domain; The CHAD

domain is an alpha-

helical domain

functionally associated

with the pfam01928

domains. It has

conserved histidines

that may chelate

metals.

CHAD; CYTH

domain

CYTH domain;

CHAD domain

NO 2pziA-11-32-0.004

mtb:TBMG_01761 RDD family RDD RDD family NO NO

mtb:TBMG_01762 NO NO Fatty acid desaturase NO NO

mtb:TBMG_01765 Predicted nucleoside-

diphosphate sugar

epimerase; atypical (a)

SDRs, subgroup 8

NAD-dependent

epimerase/dehydrat

ase; Sugar

nucleotide

epimerase YfcH,

putative

NAD dependent

epimerase/dehydratase

family

Predicted

nucleoside-

diphosphate

sugar

epimerases

(SulA family)

2p4hX-15-140-3e-34

mtb:TBMG_01769 cyclase homology

domain;

Adenylyl cyclase

class-3/4/guanylyl

cyclase

Adenylate and

Guanylate cyclase

catalytic domain

Adenylate

cyclase, family

3 (some proteins

contain HAMP

domain)

1y10C-25-229-6e-61

mtb:TBMG_01772 NO Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily; Ycf66

protein N-terminus

NO 1pw4A-11-65-3e-11

mtb:TBMG_01776 Glycerate kinase family Glycerate kinase,

flavodoxin-like

domain; Glycerate

kinase, restriction-

enzyme-like fold

domain

Glycerate kinase

family

Glycerate kinase 1to6A-27-297-3e-81

mtb:TBMG_01777 Iron-sulphur cluster

biosynthesis

FeS cluster

biogenesis; FeS

cluster insertion, C-

terminal, conserved

site

Iron-sulphur cluster

biosynthesis

Uncharacterized

ACR

2apnA-42-134-1e-32

mtb:TBMG_01782 Cytochrome c oxidase

subunit IV;

Cytochrome c

oxidase subunit IV,

bacteria

Cytochrome c oxidase

subunit IV

NO 1m56C-30-35-0.005


membrane protein;

Mycobacterium

membrane

Mycobacterium

membrane protein

NO 2b5uA-16-37-0.009

mtb:TBMG_01784 NO NO Copper resistance

protein D; Heme

exporter protein D

(CcmD)

NO NO















mtb:TBMG_01791 NlpC/P60 family; It is

found in several

lipoproteins.

NLP/P60 NlpC/P60 family Cell wall-

associated

hydrolases

(invasion-

associated

proteins)

2hbwA-21-118-1e-27

mtb:TBMG_01792 Peptidase Gluzincin

family (thermolysin-

like proteinases, TLPs)

includes peptidases M1,

M2, M3, M4, M13,

M32 and M36

(fungalysins);

NO Peptidase MA

superfamily

NO 3ciaA-16-46-5e-06


[Cell envelope

biogenesis, outer

membrane]

Glycosyl


Glycosyltransferase

Family 4; Glycosyl

transferases group 1

Predicted

glycosyltransfer

ases

2gekA-24-253-3e-68

mtb:TBMG_01795 NO NO Polyketide cyclase /

dehydrase and lipid

transport

NO 2ns9A-13-35-0.008


SRPBCC domain of an

uncharacterized

subfamily of proteins

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2d4rA-26-89-3e-19

mtb:TBMG_01797 ArsA ATPase

functionas as an efflux

pump located on the

inner membrane of the

cell; arsenite-activated

ATPase ArsA;

Arsenical pump

ATPase, ArsA/Get3

Anion-transporting

ATPase

Predicted

ATPase

involved in

chromosome

partitioning

1ihuA-20-208-1e-54

mtb:TBMG_01801 NO NO NO NO 1mhsA-8-37-0.006

mtb:TBMG_01802 NO NO Acetyltransferase

(GNAT) domain

NO NO

mtb:TBMG_01807 NO NO Helix-turn-helix

domain

NO NO

mtb:TBMG_01808 carotene biosynthesis

associated membrane

protein;

Carotene

biosynthesis-

associated

membrane protein,

type-1

NO NO 2b5uA-17-43-1e-06

mtb:TBMG_01812 NO GCN5-related N-

acetyltransferase

(GNAT) domain;

FR47-like; Acyl-

CoA N-

acyltransferase

FR47-like protein NO 2qecA-17-54-1e-08

mtb:TBMG_01816 NO NO HemX NO NO



domain; Penicillin-

binding Protein

dimerisation domain;

Cell division protein

FtsI/penicillin-binding

protein 2 [Cell


outer membrane]

Penicillin-binding

protein,

transpeptidase;

Penicillin-binding

protein,

dimerisation

domain; Beta-


dase-like

Penicillin-binding

Protein dimerisation

domain; Penicillin

binding protein

transpeptidase domain

NO 1mwxA-15-451-1e-

129


monoxygenases;

probable F420-

dependent

oxidoreductase,

Rv2161c family;

Luciferase-like,

F420-dependent

oxidoreductase,

Rv2161c

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

2i7gB-17-165-8e-42















related flavin-

dependent

oxidoreductases

mtb:TBMG_01821 NO Tetracycline

transcriptional

regulator, TetR-

related, C-terminal

NO NO 2hyjA-37-49-6e-07

mtb:TBMG_01822 NO Carboxymuconolact

one decarboxylase;

Alkylhydroperoxida

se AhpD core

Carboxymuconolacton

e decarboxylase

family

NO 2oyoA-19-135-1e-32

mtb:TBMG_01832 Multi-copper

polyphenol

oxidoreductase laccase;

Multicopper

polyphenol oxidase

(laccase) [Secondary

metabolites

biosynthesis, transport

and catabolism]

Multi-copper

polyphenol

oxidoreductase,

laccase; Cytotoxic

necrotizing factor-

like, catalytic

Multi-copper

polyphenol

oxidoreductase

laccase

Uncharacterized

ACR

1z9tA-34-316-2e-87

mtb:TBMG_01833 Type III Pyridoxal 5-

phosphate (PLP)-

Dependent Enzymes

Alanine racemase,

N-terminal

Alanine racemase, N-

terminal domain

Predicted

enzyme with a

TIM-barrel fold

3cpgA-31-241-1e-64

mtb:TBMG_01834 NO Cell division

protein SepF/SepF-

related

NO Uncharacterized

BCR

NO

mtb:TBMG_01835 YGGT family Ycf19 YGGT family NO NO

mtb:TBMG_01836 DivIVA domain; Plant

ATP synthase F0; Cell

division initiation

protein [Cell division

and chromosome

partitioning]

DivIVA DivIVA protein NO 1y4cA-17-36-0.009

mtb:TBMG_01837 NO NO Ca2+ regulator and

membrane fusion

protein; O-antigen

ligase like membrane

protein

NO NO


transferase (PRT)-type

I domain; Predicted

metal-dependent

hydrolase of the TIM-

barrel fold

Phosphoribosyltrans

ferase

Phosphoribosyl

transferase domain

Predicted

phosphoribosyltr

ansferases

1wd5A-43-183-4e-47

mtb:TBMG_01841 M20 Peptidase,

carboxypeptidase yscS-

like;

ArgE/DapE/ACY1/

CPG2/YscS,

conserved site;

Peptidase M20,

dimerisation

Peptidase dimerisation

domain

Acetylornithine

deacetylase/Suc

cinyl-

diaminopimelate

desuccinylase

and related

deacylases

2pokA-17-247-2e-66

mtb:TBMG_01842 PhosphatidylEthanolam

ine-Binding Protein

(PEBP) domain present

in bacteria and archaea

YbhB/YbcL;

Phosphatidylethanol

amine-binding

protein PEBP

Phosphatidylethanola

mine-binding protein

Phospholipid-

binding protein

1fuxA-46-172-6e-44


domain found in

phosphoglycerate

mutases and related

proteins, mostly

phosphatases;

Histidine

phosphatase

superfamily, clade-

1; Phosphomutase

MSMEG4193,

putative


superfamily

Fructose-2,6-

bisphosphatase

2a6pA-25-151-8e-38

mtb:TBMG_01847 NO NO Lactamase_B_4 NO NO














mtb:TBMG_01848 Phosphoinositide 3-

kinase (PI3K)-like

family, catalytic

domain;

NO Phosphatidylinositol

3- and 4-kinase

NO NO

mtb:TBMG_01849 Ribbon-helix-helix

protein, copG family;

CopG-like DNA-

binding

Ribbon-helix-helix


NO 2hzaA-27-34-0.010

mtb:TBMG_01852 NO NO YesK-like protein;

Positive regulator of

sigma(E), RseC/MucC

NO NO

mtb:TBMG_01855 PAC2 family; This

PAC2 (Proteasome

assembly chaperone)

family of proteins is

found in bacteria,

archaea and eukaryotes.

Proteasome

assembly chaperone

2

PAC2 family NO 2p90B-25-266-6e-72

mtb:TBMG_01860 membrane protein NO FtsH Extracellular ;

Glycine zipper 2TM

domain

NO NO


associated protein

Cas4; double-strand

break repair helicase

AddA,

alphaproteobacterial

type; AddAB, also

called RexAB,

substitutes for RecBCD

in several bacterial

lineages

Restriction

endonuclease, type

II-like

PD-(D/E)XK nuclease

superfamily

RecB family

exonuclease

1w36F-14-49-2e-06


BCR

1j27A-22-113-1e-26

mtb:TBMG_01868 Pup-ligase protein;

Pupylation is a novel

protein modification

system found in some

bacteria.

Pup

ligase/deamidase

Pup-ligase protein NO NO

mtb:TBMG_01869 Pup-like protein; Ubiquitin-like, Pup Pup-like protein NO NO

mtb:TBMG_01877 NO NO NO NO 2fhh1-63-63-2e-11

mtb:TBMG_01880 SWIM zinc finger; This

domain is found in

bacterial, archaeal and


Zinc finger, SWIM-

type

SWIM zinc finger NO NO

mtb:TBMG_01882 HNH nucleases HNH nuclease HNH endonuclease NO 2pziA-11-33-0.001

mtb:TBMG_01885 Pup-ligase protein Pup

ligase/deamidase

Pup-ligase protein NO NO

mtb:TBMG_01886 WYL domain; This

presumed domain is

around 170 amino acids

in length; Predicted


[Transcription]

NO WYL domain Predicted

transcriptional

regulator

1j5yA-18-48-2e-06

mtb:TBMG_01887 WYL domain; This

presumed domain is

around 170 amino acids

in length; Predicted


[Transcription]

NO WYL domain Predicted

transcriptional

regulator

2dbbB-18-39-0.001

mtb:TBMG_01889 Sec-independent

protein translocase

protein (TatC)

Sec-independent

protein translocase

TatC, bacterial-type

Sec-independent

protein translocase

protein (TatC)

Sec-independent

protein secretion

pathway

component TatC

NO

















mtb:TBMG_01891 NO NO Collagen triple helix

repeat (20 copies)

NO NO

mtb:TBMG_01899 NO NO NO Methyl-

accepting

chemotaxis

protein

2pziA-13-52-2e-09

mtb:TBMG_01902 Alpha/beta hydrolase; NO Alpha/beta hydrolase NO 1bu8A-18-37-7e-05

mtb:TBMG_01904 NO NO Antirestriction protein NO NO

mtb:TBMG_01905 NO NO Apolipoprotein CIII

(Apo-CIII)

NO NO

mtb:TBMG_01906 Catalytic domain of

uncharacterized

Mycobacterium

tuberculosis Rv2075c-

like proteins; C-type

lectin (CTL)/C-type

lectin-like (CTLD)

domain

Phospholipase C,

phosphatidylinositol

-specific , X

domain; PLC-like

phosphodiesterase,

TIM beta/alpha-

barrel domain

NO NO 2plcA-16-115-1e-26


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

type 12

Methyltransferase

domain

SAM-dependent

methyltransferas

es

3d2lC-15-100-5e-22


phosphate (PNP)

oxidase-like proteins

FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain; F420-

dependent enzyme,

PPOX class, family

Rv2061, putative

Pyridoxamine 5'-

phosphate oxidase

Predicted flavin-

nucleotide-

binding protein

structurally

related to

pyridoxine 5'-

phosphate

oxidase

1rfeA-19-55-8e-09

mtb:TBMG_01922 Helical backbone metal

receptor (TroA-like

domain)

ABC transporter,

metal-binding

lipoprotein

Periplasmic solute

binding protein family

ABC-type

Mn/Zn transport

system,

periplasmic

Mn/Zn-binding

(lipo)protein

(surface adhesin

A)

2o1eA-19-250-5e-67


(includes fungal


etc.)

Dienelactone

hydrolase

Dienelactone

hydrolase family

Dienelactone

hydrolase and

related enzymes

1zi8A-22-157-3e-39

mtb:TBMG_01929 YtcJ_like metal

dependent

amidohydrolases;

Predicted metal-

dependent hydrolase

with the TIM-barrel

fold

Metal-dependent

hydrolase,

composite domain;

Amidohydrolase 3

Amidohydrolase

family

Predicted metal-

dependent

hydrolase with

the TIM-barrel

fold

2puzA-15-71-6e-15

mtb:TBMG_01932 NO NO NYN domain NO NO

mtb:TBMG_01933 polyketide synthases

(PKSs); enoyl

reductase of polyketide

synthase; beta-ketoacyl

reductase (KR) domain

of fatty acid synthase

(FAS); Rossmann-fold

NAD(P)(+)-binding

Beta-ketoacyl

synthase; Acyl

transferase domain;

Phosphopantetheine

attachment site;

Acyl carrier

protein-like;

GroES-like;

Beta-ketoacyl


domain; Beta-

ketoacyl synthase, C-

terminal domain;

Acyl transferase

domain; Alcohol

dehydrogenase

Polyketide

synthase

modules and

related proteins

NO














proteins; Acyl

transferase domain;

Dehydratase domain in

polyketide synthase

(PKS) enzymes.;

Phosphopantetheine

attachment site;

Polyketide synthase

modules and related

proteins [Secondary

metabolites


and catabolism];

Enoylreductase;

Enoylreductase in

Polyketide synthases.

Alcohol

dehydrogenase, C-

terminal; Alcohol

dehydrogenase

GroES-like;

Polyketide

synthase, KR; Beta-

ketoacyl synthase,

N-terminal; Beta-

ketoacyl synthase,

C-terminal; Acyl

transferase/acyl

hydrolase/lysophos

pholipase; Malonyl-

CoA ACP

transacylase, ACP-

binding; Thiolase-

like, subgroup;

NAD(P)-binding

domain; Polyketide

synthase, beta-

ketoacyl synthase

domain; Polyketide

synthase,

phosphopantetheine

-binding; Polyketide

synthase,

enoylreductase;

GroES-like domain;

Zinc-binding

dehydrogenase; KR

domain;

Phosphopantetheine

attachment site


NAD(P)(+)-binding

proteins; PEP-utilising

enzyme, mobile domain

NAD-dependent

epimerase/dehydrat

ase; PEP-utilising

enzyme, mobile

domain; NAD(P)-

binding domain

NADH(P)-binding;

PEP-utilising enzyme,

mobile domain

Phosphoenolpyr

uvate

synthase/pyruvat

e phosphate

dikinase

NO

mtb:TBMG_01937 NO NO NO ABC-type

transport system

involved in

cytochrome c

biogenesis,

permease

component

NO


2 (NTF2-like)

superfamily.

Nuclear transport

factor 2

Nuclear transport

factor 2 (NTF2)

domain

NO 2a15A-27-73-5e-14



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters




permease component


and metabolism]

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

ABC-type sugar

transport

systems,

permease

components

2r6gF-24-272-7e-74



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component










permease component


and metabolism]

mtb:TBMG_01944 ExoU and VipD-like

proteins; Patatins and

Phospholipases;

Predicted esterase of

the alpha-beta

hydrolase superfamily

Patatin/Phospholipa

se A2-related; Acyl

transferase/acyl

hydrolase/lysophos

pholipase

Patatin-like

phospholipase

Predicted

esterase of the

alpha-beta

hydrolase

superfamily

1oxwC-14-117-4e-27

mtb:TBMG_01945 Mycothiol

maleylpyruvate


domain; MDMPI C-

terminal domain;

MDMPI C-

terminal;

Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain; MDMPI C-

terminal domain

NO 2nsfA-14-103-6e-23


SRPBCC domain of

Micromonospora

echinospora CalC and

related proteins

Activator of Hsp90

ATPase homologue

1-like; START-like

domain

Activator of Hsp90

ATPase homolog 1-

like protein

NO 1zxfA-26-147-9e-37

mtb:TBMG_01949 Nitro_FMN_reductase

super family

Nitroreductase-like Nitroreductase family NO 2iskA-12-39-0.001



I domain;

Erythromycin esterase;

Phosphoribosyltrans

ferase;

Erythromycin

esterase

Phosphoribosyl

transferase domain;

Erythromycin esterase

Erythromycin

esterase

homolog

2qgmA-20-370-1e-105

mtb:TBMG_01953 Adenine nucleotide

alpha hydrolases

superfamily including

N type ATP PPases,

ATP sulphurylases

Universal Stress

Response protein and

electron transfer

flavoprotein (ETF).

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

NO 2jaxA-25-173-2e-44


protein family.

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-50-219-7e-58

mtb:TBMG_01956 Cation efflux family;

Predicted Co/Zn/Cd

cation transporters


and metabolism]

Cation efflux

protein

Cation efflux family Predicted

Co/Zn/Cd cation

transporters

2qfiA-23-222-6e-59

mtb:TBMG_01960 NO NO Infectious salmon

anaemia virus

haemagglutinin

NO NO

mtb:TBMG_01961 Phage derived protein

Gp49-like

Addiction module

killer protein

Phage derived protein

Gp49-like

NO NO

mtb:TBMG_01963 Predicted helicase NO NO NO NO

mtb:TBMG_01964 NO NO Phage protein

Gp37/Gp68

NO NO

mtb:TBMG_01967 NO Homeodomain-like;

Winged helix-turn-

helix transcription

repressor DNA-

binding

Homeodomain-like

domain; Helix-turn-

helix domain

NO 2ga1A-18-42-2e-04














mtb:TBMG_01970 HNH nucleases; HNH endonuclease;

HNH nuclease

HNH endonuclease NO 2qgpB-18-52-3e-07

mtb:TBMG_01974 NO NO NO NO 2hh8A-13-115-6e-27


domains;

Transcriptional

regulators

[Transcription]

Winged helix-turn-

helix transcription

repressor DNA-

binding

MarR family Transcriptional

regulators

3bj6A-22-55-1e-08


Nucleoside

Triphosphate


ATPase (AAA+

superfamily)

Helix-turn-helix,

type 11

AAA domain; HTH

domain

Uncharacterized

ATPases of the

AAA

superfamily

1in4A-17-47-6e-06



nucleotide alpha



PPases, ATP




flavoprotein (ETF).

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-51-205-9e-54


Nucleoside

Triphosphate


kinase

Zeta toxin domain;

Protein kinase-like

domain

AAA domain Uncharacterized

BCR

1yj5B-12-66-1e-11


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

1vlmA-31-218-9e-58

mtb:TBMG_01985 Acyl-ACP thioesterase

[Lipid metabolism]

Acyl-ACP

thioesterase

Acyl-ACP

thioesterase

NO 2ownB-17-136-4e-33


NAD(P)(+)-binding

proteins; Pyridine

nucleotide-disulphide

oxidoreductase;

NO Pyridine nucleotide-

disulphide

oxidoreductase

NO 2vdcG-19-46-2e-07

mtb:TBMG_01987 Spore germination

protein; Amino acid

transporters [Amino

acid transport and

metabolism]; amino

acid transporter;

Amino

acid/polyamine

transporter I;

Amino acid

permease domain


transporters

NO

mtb:TBMG_01988 Members of the

ICL/PEPM enzyme

family catalyze either

P-C or C-C bond

formation/cleavage;

Phosphoenolpyruvate

phosphomutase

Aldolase-type TIM

barrel;

Pyruvate/Phosphoe

nolpyruvate kinase

Phosphoenolpyruvate

phosphomutase

PEP

phosphonomutas

e and related

enzymes

1zlpB-21-142-1e-34



nucleotide alpha



PPases, ATP




Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-42-182-8e-47













flavoprotein (ETF).

mtb:TBMG_01991 Hemerythrin (Hr) Haemerythrin/HHE

cation-binding

motif

Hemerythrin HHE

cation binding domain

NO 2p0nA-18-84-4e-17

mtb:TBMG_01999 RES domain; This

presumed domain

contains 3 highly

conserved polar groups

that could form an

active site.

RES RES domain NO NO

mtb:TBMG_02002 LysE type translocator; Lysine-type

exporter protein

(LYSE/YGGA); L-

lysine

exporter/arginine

exporter

LysE type translocator Lysine efflux

permease

NO


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I;

Methyltransferase

type 12

Methyltransferase

domain

SAM-dependent

methyltransferas

es

3d2lC-14-86-7e-18

mtb:TBMG_02013 Peptidase family M48; Peptidase M48 Peptidase family M48 Zn-dependent

protease with

chaperone

function

3c37A-15-111-1e-25

mtb:TBMG_02014 YacP-like NYN

domain;

NO YacP-like NYN

domain

NO NO

mtb:TBMG_02015 SCP_bacterial: SCP-

like extracellular

protein domain, as

found in bacteria and

archaea.

NO Cysteine-rich

secretory protein

family

NO 1smbA-17-50-3e-07

mtb:TBMG_02016 NO NO NO Succinyl-CoA

synthetase alpha

subunit

NO

mtb:TBMG_02018 NO NO PgaD-like protein NO NO

mtb:TBMG_02025 Permease NO Permease ABC-type

toluene export

system,

permease

component

NO

mtb:TBMG_02026 Permease NO Permease ABC-type

toluene export

system,

permease

component

NO

mtb:TBMG_02032 Ribbon-helix-helix

protein, copG family;

Putative addiction

module antidote

protein, CC2985;

Ribbon-helix-helix

NO Predicted

transcriptional

regulators

containing the

CopG/Arc/MetJ

DNA-binding

domain

NO

mtb:TBMG_02035 NO NO Preprotein translocase

subunit SecB

NO NO


GTPase

NO















mtb:TBMG_02047 HNH nucleases HNH endonuclease;

HNH nuclease


mtb:TBMG_02048 SEC-C motif; The

SEC-C motif found in

the C-terminus of the

SecA protein, in the

middle of some SWI2

ATPases and also solo

in several proteins;

preprotein translocase

subunit SecA;

Reviewed

SEC-C motif SEC-C motif Predicted metal-

binding protein

related to the C-

terminal domain

of SecA

2i9wA-23-43-9e-05

mtb:TBMG_02062 Type 1 glutamine

amidotransferase

NO Putative

amidotransferase

Putative

intracellular

protease/amidas

e

3bhnA-13-83-5e-17

mtb:TBMG_02063 TIGR03085 family

protein

Conserved protein

CHP03083,

actinobacterial-type

Mycothiol

maleylpyruvate


domain ; MDMPI C-

terminal domain

NO 2nsfA-12-48-1e-06

mtb:TBMG_02068 NO NO Las1-like; YtpI-like

protein

NO NO


Acyltransferases

(LPLATs) of

Glycerophospholipid

Biosynthesis

Phospholipid/glycer

ol acyltransferase


glycerol-3-

phosphate

acyltransferase

1iuqA-9-41-3e-04


(PYR1), PYR1-like

(PYL), regulatory


acid receptors


proteins

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 1fm4A-21-56-6e-09


superfamily



Zn-dependent

hydrolases,

including

glyoxylases

2cfuA-15-100-2e-22

mtb:TBMG_02082 PhosphatidylEthanolam

ine-Binding Protein

(PEBP) domain present

in bacteria and archaea

Phosphatidylethanol

amine-binding

protein PEBP

Phosphatidylethanola

mine-binding protein

Phospholipid-

binding protein

1fuxA-26-112-9e-26






sigma factors by

phosphorylation

Sulphate


a-factor antagonist

STAS; Anti-sigma

factor antagonist

STAS domain Anti-anti-sigma

regulatory factor

(antagonist of

anti-sigma

factor)

1th8B-21-124-9e-30

mtb:TBMG_02089 NO Membrane protein Membrane protein Predicted

membrane

protein

NO


Superfamily (MFS) is a

large and diverse group

of secondary

transporters that

includes uniporters,

symporters, and

antiporters; putative

sialic acid transporter;

Major Facilitator

Superfamily

Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

1pw4A-14-78-4e-15













mtb:TBMG_02094 NO Thiamin/hydroxym

ethyl pyrimidine-

binding protein-

like, putative

Phage head-tail

joining protein

Uncharacterized

ACR

1yqhA-33-90-7e-20


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-38-233-3e-62


dioxygenase (NPD)

2-nitropropane

dioxygenase, NPD;

Aldolase-type TIM

barrel

Nitronate

monooxygenase

Dioxygenases

related to 2-

nitropropane

dioxygenase

3bo9A-27-239-1e-63

mtb:TBMG_02100 NO NO Chlorosome envelope

protein C;

Enterobacterial EspB

protein

NO NO

mtb:TBMG_02103 YceI-like domain; E.

coli YceI is a base-

induced periplasmic

protein.

Lipid/polyisoprenoi

d-binding, YceI-like

YceI-like domain NO NO


methyltransferase

Leucine carboxyl

methyltransferase

Leucine carboxyl

methyltransferase

NO 2uyoA-63-61-6e-11



lC (SRPBCC) ligand-

binding domain

superfamily; SRPBCC

domains have a deep

hydrophobic ligand-

binding pocket

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

NO 2qpvA-18-39-3e-04

mtb:TBMG_02115 Superfamily of metallo-

dependent hydrolases

(also called

amidohydrolase

superfamily)

Amidohydrolase 2 Amidohydrolase NO 2qpxA-26-225-1e-59


Superfamily (MFS);

Ribosomal protein L13;

Major Facilitator

Superfamily;

helix_turn_helix

multiple antibiotic

resistance protein;

Tetracycline

resistance protein,

TetA/multidrug

resistance protein

MdtG; Sugar

transporter,

conserved site

Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

1pw4A-14-70-1e-14


phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain; FMN-

binding split barrel;

F420-binding

domain, putative

Pyridoxamine 5'-

phosphate oxidase

NO 2aq6A-25-159-2e-40

mtb:TBMG_02120 NO NO EthD domain NO 2ifxA-20-37-0.002

mtb:TBMG_02121 NO NO NO NO 2jekA-100-238-2e-64

mtb:TBMG_02123 NO Deazaflavin-

dependent

nitroreductase

NO NO 2hq9B-22-37-7e-04

mtb:TBMG_02124 NO DNA glycosylase NO NO 2jhnA-17-35-0.008
















NAD(P)(+)-binding

proteins

NAD(P)-binding

domain

NADH(P)-binding Nucleoside-

diphosphate-

sugar

epimerases

2hunA-15-107-5e-24

mtb:TBMG_02128 CoA-transferase family

III; Predicted acyl-CoA

transferases/carnitine

dehydratase [Energy

production and

conversion]

CoA-transferase

family III

CoA-transferase

family III

Predicted acyl-

CoA

transferases/carn

itine

dehydratase

NO

mtb:TBMG_02130 MOSC domain 3-alpha domain;

Molybdenum

cofactor sulfurase,

C-terminal;

Pyruvate kinase-

like, insert domain;

MOSC domain; 3-

alpha domain

Uncharacterized

BCR

1o65A-25-207-1e-54

mtb:TBMG_02131 CAAX protease self-

immunity

CAAX amino

terminal protease

CAAX protease self-

immunity

Predicted metal-

dependent

membrane

protease

NO

mtb:TBMG_02133 Transglycosylase

associated protein

Transglycosylase-

associated protein

Transglycosylase

associated protein

Predicted

membrane

proteins

1ciiA-27-43 -3e-05

mtb:TBMG_02134 Fibronectin-attachment

protein (FAP)

Fibronectin-

attachment

Fibronectin-

attachment protein

(FAP)

NO NO



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs; sulfate

transport protein

Binding-protein-

dependent transport

systems inner

membrane

component; NifC-

like ABC-type

porter; Molybdate

ABC transporter,

permease protein

Binding-protein-

dependent transport

system inner

membrane component

ABC-type

sulfate/molybdat

e transport

systems,

permease

components

3d31C-29-185-9e-48

mtb:TBMG_02147 PaaI_thioesterase is a

tetrameric acyl-CoA

thioesterase with a hot

dog fold and one of

several proteins

responsible for

phenylacetic acid (PA)

degradation in bacteria.

Phenylacetic acid

degradation-related

protein;

Thioesterase

superfamily

Thioesterase

superfamily

Uncharacterized

protein, possibly

involved in

aromatic

compounds

catabolism

NO

mtb:TBMG_02149 Peptidase family M48; Peptidase M48 Peptidase family M48 Zn-dependent

protease with

chaperone

function

3c37A-22-59-1e-09



cystathionine beta-

synthase (CBS pair)

domains associated

with the CorC_HlyC

domain; Transporter

associated domain;


proteins containing

CBS domains;


proteins containing

CBS domains

Cystathionine beta-

synthase, core;

Transporter-

associated domain;

CO dehydrogenase

flavoprotein-like,

FAD-binding,

subdomain 2

CBS domain;

Transporter associated

domain

Hemolysins and

related proteins

containing CBS

domains

2pliA-31-70-8e-13













cystathionine beta-

synthase (CBS pair)

domains associated

with the CorC_HlyC

domain; CBS domains

Cystathionine beta-

synthase, core;

Aldolase-type TIM

barrel

CBS domain Hemolysins and

related proteins

containing CBS

domains

2yvxA-20-52-1e-07

mtb:TBMG_02158 VWA ywmD type:Von

Willebrand factor type

A (vWA) domain was

originally found in the

blood coagulation

protein von Willebrand

factor (vWF)

von Willebrand

factor, type A

Bacterial extracellular

solute-binding protein;

von Willebrand factor

type A domain

NO 1amfA-16-62-4e-10

mtb:TBMG_02159 X-Pro dipeptidyl-

peptidase C-terminal

non-catalytic domain;

putative hydrolase,

CocE/NonD family

X-Pro dipeptidyl-

peptidase-like

domain;

CocE/NonD

hydrolase;

Galactose-binding

domain-like;

Peptidase

S15/CocE/NonD,

C-terminal

X-Pro dipeptidyl-

peptidase (S15 family)

; X-Pro dipeptidyl-


non-catalytic domain

Predicted acyl

esterases

1mpxA-20-345-1e-95


binding domain of

GlnR-like transcription

regulators; MerR HTH

family regulatory

protein

Transcription

regulator HTH,

MerR; DNA

binding domain,

putative

MerR HTH family

regulatory protein

Predicted

transcriptional

regulators

2dg6A-17-36-0.005

mtb:TBMG_02164 Bifunctional nuclease;

This family is a

bifunctional nuclease,

with both DNase and

RNase activity.

NO Bifunctional nuclease Uncharacterized

ACR

NO


binding domain of

MerR-like transcription

regulators; MerR HTH

family regulatory

protein;

Transcription

regulator HTH,

MerR; DNA

binding domain,

putative

MerR family

regulatory protein

Predicted

transcriptional

regulators

1r8eA-16-62-1e-10

mtb:TBMG_02166 Forkhead associated

domain (FHA)

Forkhead-

associated (FHA)

domain;

SMAD/FHA

domain


containing

proteins

2ff4A-27-104-9e-24

mtb:TBMG_02168 Uncharacterized protein

conserved in bacteria

NO NO 1c1gA-23-38-0.002

mtb:TBMG_02169 NO NO 7TM diverse

intracellular

signalling;

Mycoplasma MFS

transporter

NO NO

mtb:TBMG_02170 NO NO NO NO 2uv8G-9-39-0.002

mtb:TBMG_02173 Thiamine

pyrophosphate (TPP)

family,

BZL_OCoD_HPCL

subfamily, TPP-binding

module; Pyrimidine

(PYR) binding domain

of POX and related

proteins.; Thiamine

pyrophosphate enzyme,

central domain;

TPP-binding

enzyme, conserved

site; Thiamine

pyrophosphate

enzyme, C-terminal

TPP-binding;

Thiamine

pyrophosphate

enzyme, N-terminal

TPP-binding

domain

Thiamine

pyrophosphate

enzyme, N-terminal

TPP binding domain ;

Thiamine

pyrophosphate

enzyme, central

domain; Thiamine

pyrophosphate

enzyme, C-terminal

TPP binding domain

Thiamine

pyrophosphate-

requiring

enzymes

[acetolactate

synthase,

pyruvate

dehydrogenase

(cytochrome),

glyoxylate

carboligase,

2q28A-28-457-1e-129












phosphonopyruv

ate

decarboxylase]

mtb:TBMG_02177 NO Fumarate

reductase/succinate

dehydrogenase

flavoprotein, N-

terminal

FAD binding domain Succinate

dehydrogenase/f

umarate

reductase,

flavoprotein

subunits

1d4dA-25-305-2e-83

mtb:TBMG_02179 NO Peptidase

cysteine/serine,

trypsin-like

NO NO 2pfeA-21-100-4e-22



variety of cellular


represents an ancient

group of ATPases

belonging to the ASCE

(for additional strand,

catalytic E) division of

the P-loop NTPase

fold; type VII secretion

AAA-ATPase EccA

CbxX/CfqX;

ATPase, AAA+


secretion system

AAA-ATPase,

EccA;

Tetratricopeptide-

like helical

ATPase family

associated with

various cellular

activities (AAA)

ATPases of the

AAA+ class

NO


system protein

EccE

NO NO NO

mtb:TBMG_02200 Peptidase domain in the

S8 and S53 families

Peptidase S8/S53,

subtilisin/kexin/sed

olisin; Type VII

secretion system

peptidase S8A,

mycosin-1

Subtilase family Subtilisin-like

serine proteases

1r6vA-17-139-2e-35

mtb:TBMG_02201 Ubiquitin-like proteins Type VII secretion

system EccD

WXG100 protein

secretion system

(Wss), protein YukD ;

Plectrovirus spv1-c74

ORF 12

transmembrane

protein

NO 3c6xA-11-31-0.004

mtb:TBMG_02202 EspG family; This

family of proteins

contains the the EspG1,

EspG2 and EspG3

proteins from M.

tuberculosis.

NO EspG family NO 2hz7A-21-38-0.001


system EccB

NO NO 1m6bB-15-30-0.009

mtb:TBMG_02223 ANTAR domain;

ANTAR (AmiR and

NasR transcription

antitermination

regulators) is an RNA-

binding domain found

in bacterial

transcription

antitermination

regulatory proteins.

ANTAR domain;

Winged helix-turn-

helix transcription

repressor DNA-

binding; ANTAR

transcription anti-

termination

regulator

ANTAR domain NO NO

mtb:TBMG_02225 Zinc peptidases M18,

M20, M28, and M42.;

Predicted

aminopeptidases

Peptidase M28 Peptidase family M28 Predicted

aminopeptidases

2ek8A-16-239-7e-64











phosphate (PLP)-

Dependent Enzymes

Similar to D-Serine

Dehydratase and D-

Threonine Aldolase;

Predicted amino acid

aldolase or racemase


and metabolism]

Alanine racemase,

N-terminal


terminal domain

Predicted amino

acid aldolase or

racemase

2odoA-16-44-9e-05



Carboxymuconolact

one decarboxylase;

Alkylhydroperoxida

se AhpD core

Carboxymuconolacton

e decarboxylase

family

Uncharacterized

ACR, homolog

of gamma-

carboxymuconol

actone

decarboxylase

subunit

2q0tA-19-71-8e-14

mtb:TBMG_02229 Transcriptional

regulators CsoR

(copper-sensitive

operon repressor),

RcnR, and FrmR, and

related domains

NO Metal-sensitive

transcriptional

repressor

Uncharacterized

BCR

2hh7A-32-88-3e-19

mtb:TBMG_02231 HNH nucleases HNH endonuclease;

HNH nuclease


mtb:TBMG_02233 Putative heavy-metal-

binding

NO Putative heavy-metal-

binding

Uncharacterized

ACR

1y2iA-24-38-0.002


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 2jgpA-13-92-1e-19

mtb:TBMG_02241 EBNA-3B; Provisional NO NO NO 2vvzA-21-39-0.002


dehydrogenases and

related proteins

NO NO NO 2ho3D-15-34-0.009


NAD(P)(+)-binding

proteins

Monooxygenase,

FAD-binding;

Aromatic-ring

hydroxylase-like

FAD binding domain 2-polyprenyl-6-

methoxyphenol

hydroxylase and

related FAD-

dependent

oxidoreductases

2qa1A-22-210-5e-55

mtb:TBMG_02246 NO NO SecY translocase;

NfeD-like C-terminal,

partner-binding;

Branched-chain amino

acid transport system /

permease component

NO NO

mtb:TBMG_02247 NO NO Oxaloacetate

decarboxylase, gamma

chain ; Putative sensor

NO NO

mtb:TBMG_02251 NO NO Chorion protein NO 1ciiA-20-46-4e-06



antagonist domain of

SulP-like sulfate

transporters, plays a

role in the function and

regulation of the

transport activity;

Sulphate anion

transporter;

Sulphate


a-factor antagonist

STAS; Sulphate

transporter

Sulfate transporter N-

terminal domain with

GLY motif ; Sulfate

transporter family ;

STAS domain ;

Herpesvirus latent

membrane protein 1

(LMP1)

Sulfate

permease and

related

transporters

(MFS

superfamily)

2b5uA-16-35-3e-04














Sulfate transporter

family; Mutations in

human SLC26A2 lead

to several human

diseases; high affinity

sulphate transporter 1

mtb:TBMG_02257 NO NO CD80-like C2-set

immunoglobulin

domain

NO 2fggA-55-128-5e-31

mtb:TBMG_02260 The Tellurite-

resistance/Dicarboxylat

e Transporter (TDT)

family

C4-dicarboxylate

transporter/malic

acid transport

protein

C4-dicarboxylate

transporter/malic acid

transport protein

NO NO

mtb:TBMG_02261 The Tellurite-

resistance/Dicarboxylat

e Transporter (TDT)

family

C4-dicarboxylate

transporter/malic

acid transport

protein

C4-dicarboxylate

transporter/malic acid

transport protein

Tellurite

resistance

protein and

related

permeases

NO

mtb:TBMG_02262 2-oxoacid

dehydrogenases

acyltransferase

(catalytic domain)

2-oxoacid

dehydrogenase

acyltransferase,

catalytic domain;

Chloramphenicol

acetyltransferase-

like domain

2-oxoacid

dehydrogenases

acyltransferase

(catalytic domain)

Dihydrolipoami

de

acyltransferases

1b5sA-25-120-5e-29

mtb:TBMG_02264 Peroxiredoxin (PRX)-

like 1 family

Alkyl

hydroperoxide

reductase subunit C/

Thiol specific

antioxidant

AhpC/TSA family Thiol-disulfide

isomerase and

thioredoxins

2ywiA-54-256-2e-69

mtb:TBMG_02269 family protein Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain

NO 2nsfA-9-65-8e-12

mtb:TBMG_02271 Arsenical Resistance

Operon Repressor and

similar prokaryotic,

metal regulated

homodimeric

repressors; Helix-turn-

helix domains

Helix-turn-helix,

HxlR type; Winged

helix-turn-helix

transcription

repressor DNA-

binding

HxlR-like helix-turn-

helix

Predicted

transcriptional

regulators

2f2eA-31-118-9e-28

mtb:TBMG_02277 NO Aldolase-type TIM

barrel

NO Uncharacterized

ACR

3chvA-35-341-6e-95



conserved barrel


superfamily

Cupin, RmlC-type;


fold; Cupin 2,

conserved barrel

Cupin domain NO NO

mtb:TBMG_02279 Putative cyclase;

Proteins in this family

are thought to be

cyclase enzymes

Putative cyclase Putative cyclase Uncharacterized

ACR, predicted

metal-dependent

hydrolases

1r61A-22-176-3e-45











mtb:TBMG_02284 Pseudouridine

synthases are

responsible for the

synthesis of

pseudouridine from

uracil in ribosomal

RNA; S4/Hsp/ tRNA

synthetase RNA-

binding domain; 16S

rRNA uridine-516

pseudouridylate

synthase and related

pseudouridylate

synthases [Translation,

ribosomal structure and

biogenesis]

Pseudouridine

synthase,

RsuA/RluB/E/F;

RNA-binding S4;

Pseudouridine

synthase, RsuA and

RluB/C/D/E/F;

Pseudouridine

synthase, RsuA and

RluB/E/F,

conserved site;

Pseudouridine

synthase, catalytic

domain

S4 domain ; RNA

pseudouridylate

synthase

16S rRNA

uridine-516

pseudouridylate

synthase and

related

pseudouridylate

synthases

1kskA-32-265-9e-72

mtb:TBMG_02285 Putative transcriptional

regulators (Ypuh-like);

NO Putative

transcriptional

regulators (Ypuh-like)

Predicted

transcriptional

regulator

containing the

HTH domain

NO



antagonist domain of

SulP-like sulfate

transporters, plays a

role in the function and

regulation of the

transport activity;

Sulfate transporter

family; Mutations in

human SLC26A2 lead

to several human

diseases.

Sulphate


a-factor antagonist

STAS; Sulphate

transporter

Sulfate transporter N-

terminal domain with

GLY motif ; Sulfate

transporter family;

STAS domain

Sulfate

permease and

related

transporters

(MFS

superfamily)

1vc1A-20-57-8e-09

mtb:TBMG_02289 NO NO Permeases of the

major facilitator

superfamily

NO

mtb:TBMG_02294 HNH nucleases; 13E12

repeat family.

HNH nuclease NO NO NO

mtb:TBMG_02296 ADP-ribose

pyrophosphatase

(ADPRase) catalyzes

the hydrolysis of ADP-

ribose and a variety of

additional ADP-sugar

conjugates to AMP and

ribose-5-phosphate.

NUDIX hydrolase

domain; NUDIX

hydrolase domain-

like

NUDIX domain NTP

pyrophosphohyd

rolases

including

oxidative

damage repair

enzymes

1mk1A-92-191-8e-50

mtb:TBMG_02299 Thiamine

pyrophosphokinase C

terminal; membrane-

anchored protein

conserved in bacteria

Thiamin

pyrophosphokinase,

catalytic domain;

Thiamine

pyrophosphokinase

C-terminal

Thiamine

pyrophosphokinase C

terminal

NO 2omkA-16-97-9e-21








mtb:TBMG_02304 Tetratrico peptide

repeat

Tetratricopeptide-

like helical

Tetratrico peptide

repeat

NO 1w3bA-21-42-1e-04

mtb:TBMG_02309 ABC-2 type

transporter;

ABC transporter,

DrrB efflux protein;

ABC-2

ABC-2 type

transporter

ABC-type

multidrug

transport

system,

permease

component

1ciiA-24-36-0.009


domains

DNA-binding HTH

domain, TetR-type;

Homeodomain-like;

Tetracycline

transcriptional


C-terminal;

Transcription

regulator HTH,

TetR-type



Transcriptional

regulator

2np3B-32-115-8e-27

mtb:TBMG_02312 YMF19 super

family[cl07975], Plant

ATP synthase F0

DivIVA DivIVA protein NO 1ciiA-14-38-0.002

mtb:TBMG_02314 NMT1-like family NO ABC transporter,

phosphonate,

periplasmic substrate-

binding protein

Putative

phosphate/phosp

honate-binding

protein

1us5A-14-53-4e-08

mtb:TBMG_02318 Peroxiredoxin (PRX)-

like 2 family;

AhpC/TSA antioxidant

enzyme

Alkyl

hydroperoxide

reductase subunit C/

Thiol specific

antioxidant;

Thioredoxin-like

fold

AhpC/TSA family NO 2cx4A-14-121-8e-29


superfamily;


enzymes, putative

cysteine proteases


and metabolism]

Transglutaminase-

like


superfamily

Transglutaminas

e-like enzymes,

putative cysteine

proteases

2q3zA 13 56 2e-08

mtb:TBMG_02323 NO NO MerT mercuric

transport protein

NO NO


BCR

3djmB-27-109-3e-25

mtb:TBMG_02345 NO NO PAP2 superfamily C-

terminal

NO NO


domain; Adenylate

cyclase, family 3 (some

proteins contain HAMP

domain) [Signal

transduction

mechanisms]

Adenylyl cyclase

class-3/4/guanylyl

cyclase

Adenylate and

Guanylate cyclase

catalytic domain

Adenylate

cyclase, family

3 (some proteins

contain HAMP

domain)

1y10C-18-131-2e-31













(includes fungal


etc.)

Putative esterase Putative esterase NO 3c8dB-12-140-6e-34

mtb:TBMG_02355 Phage shock protein A

(IM30), suppresses

sigma54-dependent

transcription

[Transcription / Signal

transduction

mechanisms]

NO NO NO NO


superfamily;



Zn-dependent

hydrolases,

including

glyoxylases

1xm8A-22-210-2e-55


protein family.

Universal stress

protein A; UspA;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family;

Phosphate

acetyl/butaryl

transferase

Universal stress

protein UspA

and related

nucleotide-

binding proteins

1tq8A-85-107-2e-24

mtb:TBMG_02359 Dolichyl-phosphate-

mannose-protein

mannosyltransferase

no Dolichyl-phosphate-

mannose-protein

mannosyltransferase

no 2b5uA -21- 32- 0.003


Superfamily (MFS)

Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

1pw4A -12- 41- 7e-04

mtb:TBMG_02362 no no no Uncharacterized

ACR

2p12A- 58- 214- 6e-57

mtb:TBMG_02366 Rubredoxin-like zinc

ribbon domain;

Predicted nucleic-acid-

binding protein

containing a Zn-ribbon

rubredoxin-like zinc

ribbon domain, N-

terminal; OB-fold,

C-terminal

Rubredoxin-like zinc

ribbon domain

Predicted

nucleic-acid-

binding protein

containing a Zn-

ribbon

no

mtb:TBMG_02370 no membrane no Uncharacterized

BCR

2b5uA -18- 45- 2e-05

mtb:TBMG_02375 no Lysylphosphatidylg

lycerol synthetase

no Uncharacterized

BCR

2hqyA- 8- 41- 6e-04

mtb:TBMG_02378 no no FecCD transport

family ; Permease

family

no no

mtb:TBMG_02379 TM2 domain; TM2 TM2 domain Predicted

membrane

protein

no

mtb:TBMG_02384 Tryptophan-associated

transmembrane protein

(Trp_oprn_chp)

Trp biosynthesis

associated,

transmembrane

protein, Oprn/Chp

Tryptophan-associated

transmembrane

protein

(Trp_oprn_chp)

no no

mtb:TBMG_02387 Sodium/calcium

exchanger protein;

Ca2+/H+ antiporter


and metabolism]

Sodium/calcium

exchanger

membrane region

Sodium/calcium

exchanger protein

Ca2+/H+

antiporter

no

mtb:TBMG_02396 no Deazaflavin-

dependent

nitroreductase

no no no


NAD(P)(+)-binding

proteins; biotin

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

1vl5A -19 -122- 7e-29

















biosynthesis protein

BioC

mtb:TBMG_02401 Nudix hydrolase NUDIX hydrolase

domain

NUDIX domain ADP-ribose

pyrophosphatase

2fb1C -29- 227- 2e-60

mtb:TBMG_02402 Secretory lipase Lipase, secreted Secretory lipase no 2veoA- 26- 307- 2e-84

mtb:TBMG_02403 no no 7 transmembrane

sweet-taste receptor of

3 GCPR

no no

mtb:TBMG_02407 2'-5' RNA ligase

superfamily;

RNA ligase/cyclic

nucleotide

phosphodiesterase

2'-5' RNA ligase

superfamily

no 2d4gA -17 -61 -2e-10

mtb:TBMG_02411 no no Type IV conjugative

transfer system

lipoprotein (TraV)

no no

mtb:TBMG_02413 OpgC protein;

Acyltransferase family

Acyltransferase 3 Acyltransferase family Predicted

acyltransferases

2d3iA- 14 -32 0-.003


dependent

nitroreductase

no no 1rfeA -19- 35- 0.006



lC (SRPBCC) ligand-

binding domain

superfamily

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

no 2d4rA -20- 38- 8e-04


dioxygenase (NPD);

Nitronate

monooxygenase

2-nitropropane

dioxygenase, NPD;

Aldolase-type TIM

barrel

Nitronate

monooxygenase

Dioxygenases

related to 2-

nitropropane

dioxygenase

3bo9A -28 -231- 2e-61

mtb:TBMG_02445 PaaI_thioesterase Phenylacetic acid

degradation-related

domain;

Thioesterase

superfamily

Thioesterase

superfamily

Uncharacterized

protein, possibly

involved in

aromatic

compounds

catabolism

no



Carboxymuconolact

one decarboxylase

Carboxymuconolacton

e decarboxylase

family

Uncharacterized

ACR

2prrD -15 -106- 3e-24


family

Glycosyl



family 2

Glycosyltransfer

ases involved in

cell wall

biogenesis

2ffuA- 15- 88- 3e-18

mtb:TBMG_02459 Cytochrome C

biogenesis protein

transmembrane region;

no no no 2b5uA -17- 42- 3e-04


NAD(P)(+)-binding

proteins

no Methyltransferase

domain

SAM-dependent

methyltransferas

es

3d2lC -13- 93- 4e-20

mtb:TBMG_02462 WfgS and WfeV are

involved in O-antigen

biosynthesis

Glycosyl



family 2

Glycosyltransfer

ases involved in

cell wall

biogenesis

1xhbA -18 -57 -4e-09


NAD(P)(+)-binding

proteins

Methyltransferase

FkbM

Methyltransferase

FkbM domain

SAM-dependent

methyltransferas

es

3b3fA -15- 45- 1e-05


NAD(P)(+)-binding

proteins

Methyltransferase

FkbM

Methyltransferase

FkbM domain

SAM-dependent

methyltransferas

es

3b3fA-15-45-1e-05


NAD(P)(+)-binding

proteins;

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

2o57A-15-87-4e-18


NAD(P)(+)-binding

GDP-mannose 4,6-

dehydratase

NAD dependent

epimerase/dehydratase

GDP-D-

mannose

1n7hB-31-180-5e-47




















proteins; family dehydratase

mtb:TBMG_02470 NO NO NO NO 2b5uA-28-37-1e-04

mtb:TBMG_02472 WbqC-like protein

family;

WbqC-like protein

family

WbqC-like protein

family

NO NO


NAD(P)(+)-binding

proteins;

Methyltransferase

type 12

Methyltransferase

domain

SAM-dependent

methyltransferas

es

3d2lC-18-70-2e-13

mtb:TBMG_02474 Putative

Acyltransferase (AT),

Left-handed parallel

beta-Helix (LbH)

domain;

Bacterial transferase

hexapeptide repeat;

Trimeric LpxA-like;

Sialic acid O-

acyltransferase,

NeuD

Bacterial transferase

hexapeptide (six

repeats)

Acetyltransferas

es (the

isoleucine patch

superfamily)

3bfpA-17-137-1e-33

mtb:TBMG_02475 3-amino-5-

hydroxybenzoic acid

synthase family

(AHBA_syn).

AHBA_syn family

belongs to pyridoxal

phosphate (PLP)-

dependent aspartate

aminotransferase

superfamily (fold I).

DegT/DnrJ/EryC1/

StrS

aminotransferase;

Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain 1

DegT/DnrJ/EryC1/Str

S aminotransferase

family

Predicted

pyridoxal

phosphate-

dependent

enzyme

apparently

involved in

regulation of

cell wall

biogenesis

1mdoA-40-305-4e-84


aminotransferase

(AAT) superfamily

(fold type I) of

pyridoxal phosphate

(PLP)-dependent

enzymes.

DegT/DnrJ/EryC1/

StrS

aminotransferase;

Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain 1

DegT/DnrJ/EryC1/Str

S aminotransferase

family

Predicted

pyridoxal

phosphate-

dependent

enzyme

apparently

involved in

regulation of

cell wall

biogenesis

3bn1A-23-175-4e-45


families 32 and 68,

which for the clan GH-

J

Glycosyl hydrolase

family 43, five-

bladed beta-

propellor domain

BNR repeat-like

domain ; Glycosyl

hydrolases family 43

NO 1w2tA-19-123-4e-29


superfamily;

Phytanoyl-CoA

dioxygenase

Phytanoyl-CoA

dioxygenase (PhyH)

NO 2a1xA-15-99-6e-22

mtb:TBMG_02481 Dodecin; Dodecin is a

flavin-binding

protein,found in several

bacteria and few

archaea and represents

a stand-alone version of

the SHS2 domain.

Dodecin

flavoprotein

Dodecin NO 2ux9C-50-103-6e-24


Golgi protein;

SNARE associated

Golgi protein

SNARE associated

Golgi protein

Uncharacterized

ACR

NO

mtb:TBMG_02491 Coenzyme B12-

dependent-

methylmalonyl

coenzyme A (CoA)

mutase (MCM)-like

family;

Methylmalonyl-

CoA mutase,

alpha/beta chain,

catalytic;

Cobalamin (vitamin

B12)-dependent

enzyme, catalytic

subdomain

Methylmalonyl-CoA

mutase

Methylmalonyl-

CoA mutase, N-

terminal

domain/subunit

1reqA-44-72-2e-14












mtb:TBMG_02492 NO NO DoxX-like family ;

Virulence factor BrkB

NO NO

mtb:TBMG_02493 Band_7_stomatin_like:

A subgroup of the band

7 domain of flotillin

(reggie) like proteins

similar to stomatin and

podicin (two lipid raft-

associated integral

membrane proteins). ;

Membrane protease

subunits,

stomatin/prohibitin

homologs

[Posttranslational



Band 7 protein;

Stomatin

SPFH domain / Band

7 family

Membrane

protease

subunits,

stomatin/prohibi

tin homologs

3bk6A-36-181-2e-46

mtb:TBMG_02494 NfeD-like C-terminal,

partner-binding

Nodulation

efficiency, NfeD;

Nucleic acid-

binding, OB-fold

NfeD-like C-terminal,

partner-binding ;

Orthoreovirus

membrane fusion

protein p10

Membrane

protein

implicated in

regulation of

membrane

protease activity

3cp0A-43-67-1e-12

mtb:TBMG_02500 Von Willebrand factor

type A (vWA) domain

was originally found in

the blood coagulation


factor (vWF).

von Willebrand

factor, type A

Aerotolerance

regulator N-terminal ;


type A domain

Uncharacterized

BCR

2nvoA-13-81-4e-16

mtb:TBMG_02501 Von Willebrand factor

type A (vWA) domain

was originally found in

the blood coagulation


factor (vWF).

NO NO Uncharacterized

ACR

2nvoA-13-57-5e-09

mtb:TBMG_02505 NO NO TIR domain NO NO

mtb:TBMG_02516 This family has an

alpha/beta topology

NO NO Predicted metal-

sulfur cluster

biosynthetic

enzyme

1uwdA-31-104-9e-24

mtb:TBMG_02521 Hedgehog/Intein

domain, found in

Hedgehog proteins as

well as proteins which

contain inteins and

undergo protein

splicing; Intein/homing

endonuclease [DNA

replication,

recombination, and

SUF system FeS

cluster assembly,

SufBD; Hint

domain C-terminal;

Hint domain N-

terminal; Intein

DOD homing

endonuclease;

Intein splice site;

Hom-end-

Hom_end-associated

Hint

Predicted

membrane

components of

an

uncharacterized

iron-regulated

ABC-type

transporter SufB

NO









repair] associated Hint;

SUF system FeS

cluster assembly,

SufB

mtb:TBMG_02523 carotene biosynthesis

associated membrane

protein;

NO NO NO 1zcdA-18-34-0.001

mtb:TBMG_02527 NO NO NO NO 2fb9A-17-47-3e-06

mtb:TBMG_02531 PE family PE-PGRS family,

N-terminal

PE family NO NO


residues with WXG

NO Sensor protein DegS ;

Mitotic checkpoint

protein ; Biogenesis of

lysosome-related

organelles complex-1

subunit 2 ; Nsp1-like

C-terminal region ;

Tropomyosin like ;

Collagenase ;

Filoviridae VP35 ;

Reovirus sigma C

capsid protein ;

Baculovirus

polyhedron envelope

protein, PEP, C

terminus ;

Nucleopolyhedrovirus

P10 protein

ATPase

involved in

DNA repair

NO



lC (SRPBCC) ligand-

binding domain

superfamily

Polyketide

cyclase/dehydrase


dehydrase and lipid

transport

NO 1t17A-15-40-3e-04

mtb:TBMG_02541 Preprotein translocase

SecG subunit;

Preprotein

translocase SecG

subunit

Preprotein translocase

SecG subunit

NO 2akhA-20-45-1e-05


2 (NTF2-like)

superfamily.

NO SnoaL-like domain NO 2geyB-20-59-5e-10

mtb:TBMG_02547 NO NO NO NO 2b5uA-26-56-6e-09


catalytic domain;

L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

Uncharacterized

BCR

1zatA-16-135-2e-32

mtb:TBMG_02549 Transmembrane protein transmembrane Transmembrane

protein

NO 1up8A-13-32-0.002













polyketide synthase

expression [Signal

transduction

mechanisms /



and catabolism]

NO PucR C-terminal

helix-turn-helix

domain

Regulator of

polyketide

synthase

expression

NO


Acyltransferases

(LPLATs) of

Glycerophospholipid

Biosynthesis: MGAT-

like;

Phospholipid/glycer

ol acyltransferase


glycerol-3-

phosphate

acyltransferase

1iuqA-12-49-2e-06


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT;

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

NO 1q9jB-15-51-4e-07

mtb:TBMG_02557 Sporulation Regulator

WhiA N terminal

Sporulation

regulator WhiA, N-

terminal;

Sporulation

regulator WhiA, C-

terminal

Sporulation Regulator

WhiA N terminal ;


WhiA C terminal

domain

Uncharacterized

BCR

1dq3A-11-67-5e-12

mtb:TBMG_02558 YvcK_like LPPG:FO 2-

phospho-L-lactate

transferase

CofD/UPF0052

NO Uncharacterized

ACR

2o2zA-32-353-3e-98

mtb:TBMG_02559 P-loop ATPase protein

family; Predicted P-

loop-containing kinase

ATPase, P-loop-

containing

P-loop ATPase protein

family

Predicted P-

loop-containing

kinase

2iyvA-21-38-0.004

mtb:TBMG_02561 Ricin-type beta-trefoil;

Ricin-type beta-trefoil

lectin domain

Ricin B lectin Ricin-type beta-trefoil

lectin domain

NO 2d1zA-26-73-2e-14

mtb:TBMG_02563 NO NO Gram positive anchor NO NO


phosphate (PLP)-

Dependent Enzymes;

NO Putative serine

dehydratase domain

NO 1bd0A-16-48-1e-06


phosphate (PLP)-

Dependent Enzymes;

Alanine racemase,

N-terminal


terminal domain

NO 2dy3D-19-70-4e-13


Superfamily (MFS) ;

drug resistance

transporter,

EmrB/QacA subfamily

Sugar transporter,

conserved site;

Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

2gfpA-14-88-5e-20

mtb:TBMG_02579 YhhN-like protein YhhN-like YhhN-like protein Uncharacterized

membrane

protein

no

mtb:TBMG_02602 HNH nucleases HNH nuclease HNH endonuclease no 2qgpB-24-45-5e-05

mtb:TBMG_02604 no TfuA-like, core TfuA-like protein Uncharacterized

BCR

no

mtb:TBMG_02605 YcaO-like family; YcaO-like YcaO-like family Uncharacterized

ACR

2hfsA-15-40-0.001
















mtb:TBMG_02608 Chalcone and stilbene

synthases; Predicted

naringenin-chalcone

synthase [Secondary

metabolites


and catabolism]

Chalcone/stilbene

synthase, N-

terminal; Polyketide

synthase, type III;

Chalcone/stilbene

synthase, C-

terminal; Thiolase-

like, subgroup

Chalcone and stilbene

synthases, N-terminal

domain; Chalcone and

stilbene synthases, C-

terminal domain

Predicted

naringenin-

chalcone

synthase

1tedA-98-335-6e-93

mtb:TBMG_02609 Cytochrome b5-like

Heme/Steroid binding

domain; Fatty acid

desaturase [Lipid

metabolism]

Cytochrome b5;

Fatty acid

desaturase, type 1

Cytochrome b5-like

Heme/Steroid binding

domain ; Fatty acid

desaturase

no 1kbiA-30-91-6e-19



domain; Beta-lactamase

class C and other

penicillin binding

proteins [Defense

mechanisms]

Beta-


dase-like


class C and

other penicillin

binding proteins

1ci9A-29-274-1e-74

mtb:TBMG_02614 Serine/threonine

phosphatases, family

2C, catalytic domain;

Sulphate Transporter


antagonist domain;

Histidine kinase-like

ATPases; Anti-sigma

regulatory factor

(Ser/Thr protein kinase)

[Signal transduction

mechanisms]; PAS

fold; The PAS fold

corresponds to the

structural domain that

has previously been

defined as PAS and

PAC motifs. The PAS

fold appears in archaea,

eubacteria and eukarya.

PAS-associated, C-

terminal; Protein

phosphatase 2C-

like; Sulphate


a-factor antagonist

STAS; ATPase-

like, ATP-binding

domain; PAS fold-4

PAS fold ; Stage II

sporulation protein E

(SpoIIE) ; Histidine

kinase-like ATPase

domain ; STAS

domain

Serine

phosphatase

RsbU, regulator

of sigma subunit

1th8A-24-65-4e-11

mtb:TBMG_02615 no no Toprim domain; Anti-

sigma-K factor rskA ;

Alphaherpesvirus

tegument protein US9;

GspL periplasmic

domain ; VirB8

protein

no no

mtb:TBMG_02616 no no VirB8 protein ;

Apolipoprotein O

no no







mtb:TBMG_02621 EAL domain. Diguanylate

phosphodiesterase,

EAL domain

EAL domain EAL domain 2r6oA-37-285-9e-78


activating enzymes

(E1) of the ubiquitin-

like proteins; Proteins

of this family catalyze

the reduction of flavin

or nitrocompounds

using NAD(P)H as

electron donor in a

obligatory two-electron

transfer, utilizing FMN

or FAD as cofactor.

UBA/THIF-type

NAD/FAD binding

fold; Molybdenum

cofactor

biosynthesis,

MoeB; NAD(P)-

binding domain

ThiF family Dinucleotide-

utilizing

enzymes

involved in

molybdopterin

and thiamine

biosynthesis

family 2

1jw9B-18-255-2e-68

mtb:TBMG_02624 EAL domain.;

Diguanylate-cyclase

(DGC) or GGDEF

domain; GAF domain;

Diguanylate

phosphodiesterase,

EAL domain;

Adenylyl cyclase

class-3/4/guanylyl

cyclase; GAF

GAF domain ;

GGDEF domain ;

EAL domain

EAL domain 2r6oA-40-371-1e-103

mtb:TBMG_02631 Siderophore

biosynthesis protein

domain;

Acetyltransferase

(GNAT) domain;

Acyl-CoA N-

acyltransferase;

Siderophore

biosynthesis

protein, conserved

domain

Acetyltransferase

(GNAT) domain

Acetyltransferas

es, including N-

acetylases of

ribosomal

proteins

1yk3F-99-212-4e-56


superfamily;

no Beta-lactamase

superfamily domain

Metal-dependent

hydrolases of

the beta-

lactamase

superfamily III

1zkpA-25-196-5e-51

mtb:TBMG_02641 Rhomboid family; Peptidase S54,

rhomboid domain

Rhomboid family Uncharacterized

membrane

protein

(homolog of

Drosophila

rhomboid)

2nr9A-14-73-6e-14

mtb:TBMG_02644 Mpr1p, Pad1p N-

terminal (MPN)

domains with catalytic

isopeptidase activity

(metal-binding)

Mov34/MPN/PAD-

1

Prokaryotic homologs

of the JAB domain

Uncharacterized

ACR,

PAD1/JAB1-

related

1oi0A-18-79-3e-16

mtb:TBMG_02657 Methylmalonyl-CoA

epimerase (MMCE);


resistance

protein/Dioxygenase

superfamily;

Glyoxalase/fosfomy

cin

resistance/dioxygen

ase;

Methylmalonyl-

CoA epimerase


resistance

protein/Dioxygenase

superfamily

Lactoylglutathio

ne lyase and

related lyases

1jc4A-38-137-6e-34

mtb:TBMG_02659 no no no Predicted

nuclease of the

RecB family

no

mtb:TBMG_02677 no ATP synthase

protein I

ATP synthase I chain no no


protein

membrane Predicted membrane

protein

no 2dsjA-20-45-4e-05











mtb:TBMG_02693 Lysin domain, found in

a variety of enzymes

involved in bacterial

cell wall degradation.

This domain may have

a general peptidoglycan

binding function.;

Esterases and lipases

(includes fungal


etc.)

Putative esterase;

Peptidoglycan-

binding Lysin

subgroup;

Bacteriophage P2,

GpX

Phage Tail Protein X ;

LysM domain ;

Putative esterase

Predicted

esterase

1jjfA-18-144-3e-35


domains; Rrf2 family

protein

Transcription

regulator Rrf2-like

Transcriptional

regulator

Predicted

transcriptional

regulator

1ylfC-18-103-2e-23

mtb:TBMG_02697 Carbonic anhydrases

(CA)

Carbonic anhydrase Carbonic anhydrase Carbonic

anhydrase

1ylkA-100-202-2e-53



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs;

oligopeptide transporter

permease; Reviewed

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

ABC-type

dipeptide/oligop

eptide/nickel

transport

systems,

permease

components

no



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs

inding-protein-

dependent transport

systems inner

membrane

component

N-terminal TM

domain of

oligopeptide transport

permease C ; Binding-

protein-dependent

transport system inner

membrane component

ABC-type

dipeptide/oligop

eptide/nickel

transport

systems,

permease

components

no


Nucleoside

Triphosphate

Hydrolases

no AAA domain Recombinationa

l DNA repair

ATPase (RecF

pathway)

no

mtb:TBMG_02704 Mre11 nuclease, N-

terminal

metallophosphatase

domain; DNA repair

exonuclease [DNA

replication,

recombination, and

repair]

Metallophosphoeste

rase domain

Calcineurin-like

phosphoesterase

DNA repair

exonuclease

1ii7A-18-157-3e-39


domain found in

phosphoglycerate

mutases and related

proteins, mostly

phosphatases

Histidine

phosphatase

superfamily, clade-

1


superfamily (branch 1)

Phosphohistidin

e phosphatase

SixA

2rflH-28-119-3e-28

mtb:TBMG_02713 Peptidase family C39

mostly contains

bacteriocin-processing

endopeptidases from

bacteria;

Peptidase_C39 like

family;

Peptidase, cysteine

peptidase active site

Peptidase_C39 like

family

no no

mtb:TBMG_02719 HINT (histidine triad

nucleotide-binding

protein) subgroup

Histidine triad

(HIT) protein


tetraphosphate

(Ap4A)

hydrolase and

1y23B-33-144-2e-35











other HIT

family

hydrolases


dependent

nitroreductase

no no 2hq9B-21-35-0.005


NAD(P)(+)-binding

proteins

Monooxygenase,

FAD-binding;

Aromatic-ring

hydroxylase-like

FAD binding domain ;

Herpesvirus tegument

protein, N-terminal

conserved region

2-polyprenyl-6-

methoxyphenol

hydroxylase and

related FAD-

dependent

oxidoreductases

2r0cA-17-159-4e-40

mtb:TBMG_02722 Family-5 Uracil-DNA

glycosylases (UDG),

found in thermophilic

organisms

Uracil-DNA

glycosylase-like

Uracil DNA

glycosylase

superfamily

Uracil-DNA

glycosylase

2d3yA-48-237-2e-63

mtb:TBMG_02730 Family description;

This domain is found at

the C-terminus of a

wide variety of helicase

enzymes; DnaQ-like

(or DEDD) 3'-5'

exonuclease domain

superfamily; P-loop

containing Nucleoside

Triphosphate


nuclease (RecB family)

; Superfamily I DNA

and RNA helicases and

helicase subunits [DNA

replication,

recombination, and

repair]

exodeoxyribonuclea

se V alpha chain;

RecB family

nuclease, TM0106,

putative

RNase_H superfamily

; AAA domain

Superfamily I

DNA and RNA

helicases and

helicase

subunits

no


Superfamily (MFS);

drug resistance

transporter,

EmrB/QacA subfamily

Drug resistance

transporter

EmrB/QacA

subfamily; Major

facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

2gfpA-17-139-1e-35

mtb:TBMG_02732 no no Homeodomain-like

domain; Ubiquitinol-

cytochrome C

reductase Fe-S subunit

TAT signal ; EcsC

protein family

no no

mtb:TBMG_02742 magnesium/nickel/coba

lt transporter CorA;

Mg2+ and Co2+

transporters [Inorganic

ion transport and

metabolism]

Mg2+ transporter

protein, CorA-

like/Zinc transport

protein ZntB

CorA-like Mg2+

transporter protein

Mg2+ and Co2+

transporters

2iubF-25-232-1e-61



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters




Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component










permease component


and metabolism]



Periplasmic Binding

Protein (PBP)-

dependent ATP-

Binding Cassette

(ABC) transporters


type 2 PBPs.

Binding-protein-

dependent transport

systems inner

membrane

component

Binding-protein-

dependent transport

system inner

membrane component

ABC-type sugar

transport

systems,

permease

components

2r6gF-19-195-1e-50

mtb:TBMG_02747 no no Fatty acid desaturase no no

mtb:TBMG_02749 MgtE intracellular N

domain;

CBS_pair_Mg_transpor

ter; Mg/Co/Ni

transporter MgtE

(contains CBS domain)


and metabolism]

Cystathionine beta-

synthase, core;

Magnesium

transporter, MgtE

intracellular

domain; PRC-

barrel-like

MgtE intracellular N

domain; CBS domain

Mg/Co/Ni

transporter

MgtE (contains

CBS domain)

2yvxA-27-253-3e-68

mtb:TBMG_02751 Lytic Transglycosylase

(LT) and Goose Egg

White Lysozyme

(GEWL) domain;

Membrane-bound lytic

murein

transglycosylase B

[Cell envelope

biogenesis, outer

membrane]

Homeobox protein,

antennapedia type,

conserved site;

Lysozyme-like

domain

Transglycosylase SLT

domain

Membrane-

bound lytic

murein

transglycosylase

B

1qusA-18-118-3e-27

mtb:TBMG_02752 MRP (Multiple

Resistance and pH

adaptation) is a

homologue of the

Fer4_NifH

superfamily; ATPases

involved in

chromosome

partitioning [Cell

division and

chromosome

partitioning]

Mrp, conserved site;

ATPase-like,

ParA/MinD

ParA/MinD ATPase

like

ATPases

involved in

chromosome

partitioning

2ph1A-35-280-4e-76

mtb:TBMG_02753 Antitoxin Phd_YefM,


system

Bacteriophage P1,

prevent-host-death

protein

Antitoxin Phd_YefM,


system

no no

mtb:TBMG_02755 Bacterial PH domain no Bacterial PH domain Uncharacterized

ACR

no

mtb:TBMG_02756 Bacterial PH domain;

Predicted membrane

protein

no Bacterial PH domain no no

mtb:TBMG_02757 Haloacid dehalogenase-

like hydrolases;

Predicted sugar

phosphatases of the

HAD superfamily


and metabolism]

Haloacid

dehalogenase-like

hydrolase; HAD-

superfamily

hydrolase,

subfamily IIA;

Nitrophenylphospha

Haloacid

dehalogenase-like

hydrolase ; HAD-

hyrolase-like

Predicted sugar

phosphatases of

the HAD

superfamily

2oycA-27-239-3e-64










tase-like domain

mtb:TBMG_02765 ABC-2 type

transporter;

no ABC-2 family

transporter protein

Putative

exporter of

polyketide

antibiotics

2pziA-14-32-0.002


methyltransferase;

Isoprenylcysteine

carboxyl

methyltransferase

Phospholipid

methyltransferase

Putative protein-

S-

isoprenylcystein

e

methyltransferas

e

no

mtb:TBMG_02767 X-Pro dipeptidyl-


non-catalytic domain;

putative hydrolase,

CocE/NonD family

X-Pro dipeptidyl-

peptidase-like

domain;

CocE/NonD

hydrolase;

Galactose-binding

domain-like;

Peptidase

S15/CocE/NonD,

C-terminal;

Peptidase

S15/CocE/NonD,

C-terminal

X-Pro dipeptidyl-

peptidase (S15 family)

; X-Pro dipeptidyl-


non-catalytic domain

Predicted acyl

esterases

1ju3A-20-293-6e-80

mtb:TBMG_02773 DivIVA domain; This

model describes a

domain found in

Bacillus subtilis cell

division initiation

protein DivIVA, and

homologs, toward the

N-terminus

DivIVA domain IncA protein ; N-

terminal domain ;

DivIVA protein

no no

mtb:TBMG_02779 no no Tetratricopeptide

repeat

no no



polyketide synthase

expression [Signal

transduction

mechanisms /



and catabolism]

no PucR C-terminal

helix-turn-helix

domain

Regulator of

polyketide

synthase

expression

no


(includes fungal





family;

no Alpha/beta hydrolase

family

Predicted

hydrolases or

acyltransferases

(alpha/beta

hydrolase

superfamily)

1tcaA-16-121-2e-28


(includes fungal





family;


family

no 1va4A-22-232-5e-62









mtb:TBMG_02792 Alpha/beta hydrolase

family


family

Predicted

hydrolases or

acyltransferases

(alpha/beta

hydrolase

superfamily)

2psfA-20-114-3e-26



polyketide synthase

expression [Signal

transduction

mechanisms /



and catabolism]

no PucR C-terminal

helix-turn-helix

domain

Regulator of

polyketide

synthase

expression

no

mtb:TBMG_02798 PE-PPE domain; PE-PPE, C-terminal PE-PPE domain no 2czqA-15-37-0.005


Nucleoside

Triphosphate

Hydrolases; DNA or

RNA helicases of

superfamily II

[Transcription / DNA

replication,

recombination, and

repair]

Helicase, C-

terminal;

Helicase/UvrB

domain; DEAD-like

helicase

Type III restriction

enzyme, res subunit ;

Helicase conserved C-

terminal domain

DNA or RNA

helicases of

superfamily II

no

mtb:TBMG_02805 Virulence activator

alpha C-term; Helix-

turn-helix domains

Transcription

regulator PadR N-

terminal; Winged

helix-turn-helix

transcription

repressor DNA-

binding;

Transcription

regulator PadR, C-

terminal

Transcriptional

regulator PadR-like

family; Virulence

activator alpha C-term

Predicted

transcriptional

regulators

1yg2A-29-140-2e-34

mtb:TBMG_02810 no no Hemolysin-type

calcium-binding

repeat (2 copies)

no no

mtb:TBMG_02825 no Pistil-specific

extensin-like

protein

no no no




apyrimidinic site)


glycosidases (Alka-


glycosidases

HhH-GPD domain;

DNA glycosylase

HhH-GPD

superfamily base

excision DNA repair

protein

Predicted

EndoIII-related

endonuclease

1m3qA-20-48-8e-07


phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain

Pyridoxamine 5'-

phosphate oxidase

no 2aq6A-100-177-6e-46

mtb:TBMG_02828 no no no no 2hiyD-22-158-8e-40

mtb:TBMG_02833 HNH nucleases; HNH endonuclease;

HNH nuclease

HNH endonuclease no 2cfmA -12- 32- 0.004

mtb:TBMG_02834 DDE superfamily

endonuclease

no DDE superfamily

endonuclease

no no

mtb:TBMG_02835 no Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

2gs9A-22-59-1e-09















methyltransferase

Isoprenylcysteine

carboxyl

methyltransferase

Isoprenylcysteine

carboxyl

methyltransferase

(ICMT) family

Uncharacterized

BCR

no


protein

no 1a0cA-13-34-9e-04

mtb:TBMG_02854 HNH nucleases HNH nuclease HNH endonuclease no 2qgpB-13-40-0.002

mtb:TBMG_02856 no no Polyketide cyclase /

dehydrase and lipid

transport

no 1z6rA-17-37-0.004


Acyl-CoA


no Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA-16-45-3e-05


domain

Adenylyl cyclase

class-3/4/guanylyl

cyclase

Adenylate and

Guanylate cyclase

catalytic domain

Adenylate

cyclase, family

3 (some proteins

contain HAMP

domain)

1y10C-15-62-7e-11

mtb:TBMG_02863 Class III nucleotidyl

cyclases

Adenylyl cyclase

class-3/4/guanylyl

cyclase

Adenylate and

Guanylate cyclase

catalytic domain

no 1ybtB-33-39-2e-04

mtb:TBMG_02864 no no Orthopoxvirus protein no 2if6A-18-81-3e-16


monooxygenase

Antibiotic

biosynthesis

monooxygenase;

Dimeric alpha-beta

barrel

Antibiotic

biosynthesis

monooxygenase

Uncharacterized

ACR

2pd1A-22-78-1e-15

mtb:TBMG_02868 no no no Cell wall-

associated

hydrolases

(invasion-

associated

proteins)

2evrA-17-75-1e-14

mtb:TBMG_02872 Yip1 domain no Hydroxyethylthiazole

kinase family ; Yip1

domain

no no

mtb:TBMG_02883 pheromone autoinducer

2 transporter

no Predicted permease no no

mtb:TBMG_02899 Cis (Z)-Isoprenyl

Diphosphate Synthases

(cis-IPPS);

Undecaprenyl

pyrophosphate synthase

[Lipid metabolism]

Di-trans-poly-cis-

decaprenylcistransf

erase-like

Putative undecaprenyl

diphosphate synthase

Undecaprenyl

pyrophosphate

synthase

2vg1A-46-111-4e-26

mtb:TBMG_02903 TRX domain, SSP411

protein family; AGE

domain; N-acyl-D-

glucosamine 2-

epimerase domain;

Highly conserved

protein containing a

thioredoxin domain

[Posttranslational



Six-hairpin

glycosidase-like;

Thioredoxin-like

fold;

Spermatogenesis-

associated protein

20

N-acylglucosamine 2-

epimerase (GlcNAc 2-

epimerase)

Highly

conserved

protein

containing a

thioredoxin

domain

2zblB-15-155-3e-40

mtb:TBMG_02904 no no HAMP domain ;

Transmembrane

alpha-helix domain;

MacB-like

periplasmic core

domain

no no

mtb:TBMG_02537 no Sensor protein DegS;

Biogenesis of

lysosome-related

ATPase

involved in

DNA repair

no

















organelles complex-1

subunit 2; Filoviridae

VP35; Reovirus sigma

C capsid protein;

Myosin tail;

Baculovirus

polyhedron envelope

protein, PEP, C

terminus;

Proteins of 100

residues with WXG;



lC (SRPBCC) ligand-

binding domain

superfamily

Polyketide

cyclase/dehydrase


dehydrase and lipid

transport

no 1t17A-15-40-3e-04

mtb:TBMG_02541 Preprotein translocase

SecG subunit;

Preprotein

translocase SecG

subunit

Preprotein translocase

SecG subunit

no 2akhA-20-45-1e-05


2 (NTF2-like)

superfamily.

no SnoaL-like domain no 2geyB-20-59-5e-10


catalytic domain;

L,D-transpeptidase

catalytic domain

L,D-transpeptidase

catalytic domain

Uncharacterized

BCR

1zatA-16-135-2e-32


protein

no 1up8A-13-32-0.002



polyketide synthase

expression [Signal

transduction

mechanisms /



and catabolism]

no PucR C-terminal

helix-turn-helix

domain

Regulator of

polyketide

synthase

expression

no


Acyltransferases

(LPLATs) of

Glycerophospholipid

Biosynthesis: MGAT-

like

Phospholipid/glycer

ol acyltransferase;


glycerol-3-

phosphate

acyltransferase

1iuqA-12-49-2e-06


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 1q9jB-15-51-4e-07

mtb:TBMG_02557 Sporulation Regulator

WhiA N terminal;

Sporulation

regulator WhiA, N-

terminal;

Sporulation

regulator WhiA, C-

terminal


WhiA N terminal;


WhiA C terminal

domain

Uncharacterized

BCR

1dq3A-11-67-5e-12

mtb:TBMG_02558 YvcK_like; LPPG:FO 2-

phospho-L-lactate

transferase

CofD/UPF0052

no Uncharacterized

ACR

2o2zA-32-353-3e-98

mtb:TBMG_02559 P-loop ATPase protein

family; P-loop-

containing kinase

ATPase, P-loop-

containing

P-loop ATPase protein

family

Predicted P-

loop-containing

kinase

2iyvA-21-38-0.004












mtb:TBMG_02561 Ricin-type beta-trefoil;

Ricin-type beta-trefoil

lectin domain;

Ricin B lectin Ricin-type beta-trefoil

lectin domain

no 2d1zA-26-73-2e-14


binding domain of


from the MerR

superfamily

DNA binding

domain, putative;

Winged helix-turn-

helix transcription

repressor DNA-

binding

Helix-turn-helix

domain

NO NO

mtb:TBMG_02942 NO NO ImpE protein NO NO


transferase

NO NO



[Transcription]

NO NO NO NO

mtb:TBMG_02945 Trypsin-like serine

protease

Peptidase

cysteine/serine,

trypsin-like

Trypsin-like peptidase

domain

Trypsin-like

serine proteases,

typically

periplasmic,

contain C-

terminal PDZ

domain

1te0A- 21- 197-2e-51


ACR BeTs to 4

clades

NO

mtb:TBMG_02963 Septum formation

initiator

Septum formation

initiator

Septum formation

initiator

Septum

formation

initiator

NO

mtb:TBMG_02981 NO NO Beta-galactosidase NO 1qtwA- 16- 31- 0.007

mtb:TBMG_02985 Dolichyl-phosphate-

mannose-protein

mannosyltransferase;

Dolichyl-phosphate-

mannose--protein O-

mannosyl transferase

[Posttranslational



Glycosyl

transferase, family

39

Dolichyl-phosphate-

mannose-protein

mannosyltransferase

Dolichyl-

phosphate-

mannose--

protein O-

mannosyl

transferase

PMT1

1ciiA-26-34-0.001


superfamily

Oxoglutarate/iron-

dependent

oxygenase

2OG-Fe(II) oxygenase

superfamily

Alkylated DNA

repair protein

2iuwA-26-121-2e-28


CAP family of

transcription factors; N-

Acyltransferase

superfamily;

Acetyltransferases,

including N-acetylases

of ribosomal proteins


structure and

biogenesis]

GNAT domain;

Cyclic nucleotide-

binding domain;


fold; Acyl-CoA N-

acyltransferase;

Cyclic nucleotide-

binding, conserved

site

Cyclic nucleotide-

binding domain ;

Acetyltransferase

(GNAT) domain

Histone

acetyltransferase

HPA2 and

related

acetyltransferase

s

2qcsB-16-122-9e-29

mtb:TBMG_02993 no no no no 1jhnA-11-38-0.002

mtb:TBMG_02997 5-

formyltetrahydrofolate

cyclo-ligase family;

5-

formyltetrahydrofol

ate cyclo-ligase

5-

formyltetrahydrofolate

cyclo-ligase family

5-

formyltetrahydr

ofolate cyclo-

ligase

1wkcA-29-111-1e-25

mtb:TBMG_02998 Zinc ribbon domain;

putative regulatory

protein, FmdB family

Regulatory protein,

FmdB, putative

Zinc ribbon domain Uncharacterized

BCR

1m2kA-37-42-3e-05
















mtb:TBMG_02999 SAF domain; SAF domain SAF domain no no

mtb:TBMG_03001 Hydroxyneurosporene

synthase (CrtC)

Hydroxyneurospore

ne synthase; AttH-

like domain

Hydroxyneurosporene

synthase (CrtC)

no 2ichB-32-387-1e-108

mtb:TBMG_03012 no no no no 2pgfA -14-300.009

mtb:TBMG_03021 Thermus thermophilus

CsoR, a Cu(I)-sensing

transcriptional

regulator, and related

domains

Metal-sensitive

transcriptional

repressor

Metal-sensitive

transcriptional

repressor

Uncharacterized

BCR

2hh7A -100 -103 -5e-

24

mtb:TBMG_03022 no no Cell wall-active

antibiotics response

protein

no no

mtb:TBMG_03024 no no Methyltransferase

domain

no no

mtb:TBMG_03025 Alpha/beta hydrolase no Alpha/beta hydrolase no 1ljrA -16 -37- 0.005

mtb:TBMG_03030 no von Willebrand

factor, type A


type A domain

no 2nvoA- 10- 43- 1e-06

mtb:TBMG_03034 no no Transmembrane

Fragile-X-F protein

no no

mtb:TBMG_03035 no no Glycine rich protein

family

no no

mtb:TBMG_03038 Peptidase family M23; Duplicated hybrid

motif; Peptidase

M23

Peptidase family M23 Membrane

proteins related

to

metalloendopept

idases

1qwyA -26 -136 -3e-

33

mtb:TBMG_03040 Chorismate mutase

type II

Chorismate mutase,

high GC Gram-

positive

bacteria/archaeal

Chorismate mutase

type II

Chorismate

mutase

2vklA -98- 70-2e-13

mtb:TBMG_03042 Putative esterase no Putative esterase no 1f0nA- 40- 109 -8e-26



antagonist domain

found in the C-terminal

region of sulphate

transporters as well as

in bacterial and

archaeal proteins

involved in the

regulation of sigma

factors

Sulphate


a-factor antagonist

STAS

STAS domain no 1th8B- 22- 36 -0.005

mtb:TBMG_03063 conserved protein

related to

dihydrodipicolinate

reductase

Dihydrodipicolinate

reductase, N-

terminal; NAD(P)-

binding domain

Dihydrodipicolinate

reductase, N-terminus

Uncharacterized

ACR related to

dihydrodipicolin

ate reductase

1dihA -15 -78- 2e-15


FMN reductase

NADPH-dependent

FMN reductase

NADPH-dependent

FMN reductase

Multimeric

flavodoxin

WrbA

2fzvB- 15- 61- 2e-10

mtb:TBMG_03066 GGCT-like domains,

also called AIG2-like

family; This family

consists of a number of

bacterial and phage

proteins

Butirosin

biosynthesis, BtrG-

like; Gamma-

glutamylcyclotransf

erase

AIG2-like family no 3cryA- 26- 181- 2e-46


superfamily

GNAT domain;

Acyl-CoA N-

acyltransferase

Acetyltransferase

(GNAT) domain

Histone

acetyltransferase

HPA2 and

related

acetyltransferase

s

1wwzA- 18- 53- 4e-08



















mtb:TBMG_03071 no Ribbon-helix-helix;

Vibrio phage ICP1,

Orf50

no no 1y9bA -24- 75 -1e-14



lC (SRPBCC) ligand-

binding domain

superfamily;

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

no 2ns9A -17- 72 -1e-13

mtb:TBMG_03080 MT0933-like antitoxin

protein

no MT0933-like antitoxin

protein

no no



domain; Beta-lactamase

class C and other

penicillin binding

proteins [Defense

mechanisms]

Beta-


dase-like; Peptidase

S12, Pab87-related,

C-terminal


class C and

other penicillin

binding proteins

1ei5A- 18- 177- 5e-45


superfamily;

N-acyl-

phosphatidylethanol

amine-hydrolysing

phospholipase D

Beta-lactamase

superfamily domain

Predicted Zn-

dependent

hydrolases of

the beta-

lactamase fold

3bv6B -17 -153 -6e-38

mtb:TBMG_03088 Ribosomal protein

L4/L1 family

no no no no


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT;

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA- 16- 80 -8e-16


methyltransferase;

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-39-184-2e-47

mtb:TBMG_03100 Exonuclease-

Endonuclease-

Phosphatase (EEP)

domain superfamily;

Endonuclease/exon

uclease/phosphatase

Endonuclease/Exonucl

ease/phosphatase

family

no 1zwxA- 17- 182- 1e-

46

mtb:TBMG_03102 no no Disintegrin no no

mtb:TBMG_03105 Ferritin-like

superfamily of diiron-

containing four-helix-

bundle proteins

no P-aminobenzoate N-

oxygenase AurF

no 3chtA- 14- 220- 3e-58

mtb:TBMG_03108 no no 7TM diverse

intracellular signalling

no 2b5uA -23- 40- 2e-04

mtb:TBMG_03114 H+ Antiporter protein; Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

2cfqA- 12- 49- 3e-08

mtb:TBMG_03116 FIST N domain; FIST

C domain;

FIST domain, N-

terminal; FIST C

domain

FIST N domain ; FIST

C domain

no no

mtb:TBMG_03118 PE family; PE-PGRS family,

N-terminal

PE family no no


membrane

protein

no


SRPBCC domain

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

no 2rerA-18-74-2e-14



















SRPBCC domain

Streptomyces

cyclase/dehydrase


dehydrase and lipid

transport

no 2d4rA-18-92-2e-20


SRPBCC domain

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

no 2rerA-21-81-8e-17


Superfamily (MFS)

Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

2cfqA-15-73-1e-13

mtb:TBMG_03149 no no Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

no


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I;

Methyltransferase

type 11

Methyltransferase

domain

SAM-dependent

methyltransferas

es

3busA-25-141-2e-34

mtb:TBMG_03154 Nucleotidyl transferase no Nucleotidyl

transferase; Tungro

spherical virus-type

peptidase

no no

mtb:TBMG_03158 Nucleoside deaminases

include adenosine,

guanine and cytosine

deaminases.

CMP/dCMP

deaminase, zinc-

binding; Cytidine

deaminase-like

Cytidine and

deoxycytidylate

deaminase zinc-

binding region

Cytosine/adenos

ine deaminases

1z3aA-24-190-9e-50

mtb:TBMG_03162 no Carbohydrate-

binding-like fold;

Carboxypeptidase,

regulatory domain

Bacterial Ig-like

domain (group 1) ;

FixH

no no


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I;

Cyclopropane fatty acid

synthase and related

methyltransferases

[Cell envelope

biogenesis, outer

membrane]

no Methyltransferase

domain

SAM-dependent

methyltransferas

es

1wznA-18-103-2e-23

mtb:TBMG_03167 no no Transposase no no

mtb:TBMG_03171 Proteins of this family

catalyze the reduction

of flavin or

nitrocompounds using

NAD(P)H as electron

donor in a obligatory

two-electron transfer,

utilizing FMN or FAD

as cofactor.

Nitroreductase-like Nitroreductase family no 2iskA-10-45-2e-05

mtb:TBMG_03172 no Integrase, catalytic

core; Ribonuclease

H-like domain

Integrase core domain no 1c6vA-22-41-2e-04


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA-14-85-2e-17

mtb:TBMG_03174 Nitro_FMN_reductase

super family;

Nitroreductase-like Nitroreductase family no 2iskA-13-41-3e-04
















protein family.

Universal stress

protein A;

Rossmann-like

alpha/beta/alpha

sandwich fold

Universal stress

protein family

Universal stress

protein UspA

and related

nucleotide-

binding proteins

2jaxA-26-177-2e-45

mtb:TBMG_03185 no no EspG protein no no

mtb:TBMG_03209 found at the C-terminus

of proteins that contain

a transglutaminase core

domain

no no no no


dependent

nitroreductase

YlbE-like protein no 2hq9B-19-37-8e-04


domain: Superfamily

no PIN domain no 2fe1A-27-68-1e-12


domain: Superfamily;

no PIN domain no 2fe1A-27-68-1e-12



system

Bacteriophage P1,

prevent-host-death

protein

Antitoxin Phd_YefM,


system

Response

regulators

consisting of a

CheY-like

receiver domain

and a winged-

helix DNA-

binding domain

2odkD-26-44-2e-05

mtb:TBMG_03226 Phage derived protein Addiction module

killer protein

Phage derived protein

Gp49-like

no 1w1hB-29-40-8e-05

mtb:TBMG_03228 no no Helix-turn-helix no no

mtb:TBMG_03229 RES domain; RES RES domain no no


monoxygenases

Luciferase-like

domain

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

3c8nA-18-111-6e-26


ACR

no

mtb:TBMG_03236 MoeZ/MoeB domain no no no no


protein

no no no 2q83A-13-42-2e-04

mtb:TBMG_03251 no no no no 1hv5E-18-37-0.007

mtb:TBMG_03254 no Mycobacterium

membrane

Mycobacterium

membrane protein

no 1oqyA-24-38-0.001

mtb:TBMG_03255 tRNA-(MS[2]IO[6]A)-

hydroxylase (MiaE)-

like;

Ferritin/ribonucleoti

de reductase-like

tRNA-

(MS[2]IO[6]A)-

hydroxylase (MiaE)-

like

no 1otkA-11-36-0.009

mtb:TBMG_03257 no Quinonprotein

alcohol

dehydrogenase-like

PQQ-like domain no 1l0qA-24-42-1e-04

mtb:TBMG_03263 Diacylglycerol kinase

catalytic domain;

Sphingosine kinase and

enzymes related to

eukaryotic

diacylglycerol kinase

[Lipid metabolism /

General function

Diacylglycerol

kinase, catalytic

domain

Diacylglycerol kinase

catalytic domain

no 2bonA-17 -40-4e-34



















prediction only]

mtb:TBMG_03271 YbaK-like. The YbaK

family of deacylase

domains includes the

INS amino acid-editing

domain of the bacterial

class II prolyl tRNA

synthetase (ProRS),

and it's trans-acting

homologs, YbaK,

ProX, and PrdX.

no no no no

mtb:TBMG_03272 YbaK-like. The YbaK

family of deacylase

domains includes the

INS amino acid-editing

domain of the bacterial

class II prolyl tRNA

synthetase (ProRS),

and it's trans-acting

homologs, YbaK,

ProX, and PrdX.

YbaK/aminoacyl-

tRNA synthetase-

associated domain

YbaK / prolyl-tRNA

synthetases associated

domain

Uncharacterized

ACR

1dbuA-36-100-1e-22


ACR

2icuB-26-187-1e-48

mtb:TBMG_03281 acyltransferase,

WS/DGAT/MGAT

no no no no


Acyl-CoA


O-acyltransferase,

WSD1, N-terminal

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 1q9jB-12-41-2e-04


methyltransferase

NnrU NnrU protein Putative protein-

S-

isoprenylcystein

e

methyltransferas

e

no

mtb:TBMG_03289 RaiA ("ribosome-

associated inhibitor A",

also known as Protein

Y (PY), YfiA, and

SpotY, is a stress-

response protein that

binds the ribosomal

subunit interface and

arrests translation by

interfering with

aminoacyl-tRNA

binding to the

ribosomal A site.

Ribosomal protein

S30Ae/sigma 54

modulation protein

Sigma 54 modulation

protein / S30EA

ribosomal protein

Ribosome-

associated

protein Y (PSrp-

1)

2ywqC-34-90-2e-19



I domain; Predicted

amidophosphoribosyltr

ansferases

Phosphoribosyltrans

ferase

NADH

pyrophosphatase zinc

ribbon domain ;

Phosphoribosyl

transferase domain

Predicted

amidophosphori

bosyltransferase

s

1o57A-16-47-4e-06

mtb:TBMG_03302 2-polyprenyl-6-

methoxyphenol

hydroxylase and related

FAD-dependent

oxidoreductases

[Coenzyme metabolism

no NAD(P)-binding

Rossmann-like

domain

no 2r0cA-12-51-6e-07










/ Energy production

and conversion]

mtb:TBMG_03304 no no no no 1wiwB-17-65-3e-11

mtb:TBMG_03306 no no A20-like zinc finger no no

mtb:TBMG_03307 Possibl zinc metallo-

peptidase;

no Possibl zinc metallo-

peptidase

no no


transcriptional

attenuator domain;

LytR cell envelope-


attenuator; This family

appears at the C-

terminus of members of

the LytR_cpsA_psr

Cell envelope-

related

transcriptional

attenuator


transcriptional

attenuator domain;

LytR cell envelope-


attenuator

Transcriptional

regulator

no

mtb:TBMG_03316 AMP-binding enzyme; no AMP-binding enzyme Acyl-coenzyme

A

synthetases/AM

P-(fatty) acid

ligases

1mdbA-17-8- 3e-18

mtb:TBMG_03317 no no 60s Acidic ribosomal

protein

no no

mtb:TBMG_03319 Predicted Co/Zn/Cd

cation transporters


and metabolism]

Cation efflux

protein

Cation efflux family no 2qfiA-17-126-2e-30

mtb:TBMG_03320 CoA-transferase family

III; Predicted acyl-CoA

transferases/carnitine

dehydratase [Energy

production and

conversion]

CoA-transferase

family III

CoA-transferase

family III

Predicted acyl-

CoA

transferases/carn

itine

dehydratase

2g04A-26-322-8e-89

mtb:TBMG_03325 GtrA-like protein; GtrA-like protein GtrA-like protein Uncharacterized

membrane

protein

no

mtb:TBMG_03326 Bacterial PH domain;

diguanylate cyclase

AdrA;

no Bacterial PH domain ;

VIT family

no 2ahxB-22-44-3e-05

mtb:TBMG_03329 Acyl-CoA carboxylase

epsilon subunit

no Acyl-CoA

carboxylase epsilon

subunit

no no

mtb:TBMG_03340 no no Glyoxalase/Bleomycin

resistance

protein/Dioxygenase

superfamily

no 2rjbC-37-540-1e-154

mtb:TBMG_03342 found C-terminal to an

ATPase core family.

no Uncharacterized

ATPases of the AAA

superfamily

no no

mtb:TBMG_03352 GGCT-like domains,

also called AIG2-like

family.

AIG2-like;

Butirosin

biosynthesis, BtrG-

like; Gamma-

glutamylcyclotransf

erase

AIG2-like family no 3cryA-24-198-3e-52

mtb:TBMG_03360 Alpha/beta hydrolase

family


family

Predicted

hydrolases or

acyltransferases

(alpha/beta

hydrolase

superfamily)

2vf2A-19-91-3e-19
















mtb:TBMG_03378 Acetyl ornithine

aminotransferase

family;

Aminotransferase

class-III; Pyridoxal

phosphate-

dependent

transferase

Aminotransferase

class-III

Adenosylmethio

nine-8-amino-7-

oxononanoate

aminotransferas

e

2ordA-31-328-2e-90


Superfamily (MFS);

MFS transporter, sugar

porter (SP) family

Sugar/inositol

transporter; General

substrate

transporter; Major

facilitator

superfamily

domain, general


Sugar (and other)

transporter

Permeases of the

major facilitator

superfamily

2gfpA-12-74-7e-16

mtb:TBMG_03382 no no no no 2pziA-9-39-0.002

mtb:TBMG_03383 no no no Ribosomal

protein S7

no

mtb:TBMG_03387 acetoin dehydrogenase

E2 subunit

dihydrolipoyllysine-

residue

acetyltransferase


family

Predicted

hydrolases or

acyltransferases

(alpha/beta

hydrolase

superfamily)

1iupA-19-143-2e-35

mtb:TBMG_03406 no no FxsA cytoplasmic

membrane protein

no no



system

Bacteriophage P1,

prevent-host-death

protein

Antitoxin Phd_YefM,


system

Uncharacterized

ACR

2a6qA-44-106-7e-25

mtb:TBMG_03409 Plasmid stabilisation

system protein

no Plasmid encoded toxin

Txe

no 2a6sB-45-116-2e-27


domain (FHA)

Forkhead-

associated (FHA)

domain;

SMAD/FHA

domain


containing

proteins

1uhtA-22-79-2e-16

mtb:TBMG_03412 Pentapeptide repeats Pentapeptide repeat Pentapeptide repeats Uncharacterized

low-complexity

proteins

2bm5A-100-181-6e-47

mtb:TBMG_03414 no no Levivirus coat protein no no

mtb:TBMG_03416 Histidine kinase-like

ATPases; Signal

transduction histidine

kinase [Signal

transduction

mechanisms]

ATPase-like, ATP-

binding domain;

HAMP linker

domain

HAMP domain ;

Histidine kinase-,

DNA gyrase B-, and

HSP90-like ATPase

Signal

transduction

histidine kinase

no


N-terminal

PE family no no


phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain; F420-

dependent enzyme,

PPOX class, family

Rv3369, probable

Pyridoxamine 5'-

phosphate oxidase

no 2aq6A-25-78-9e-16

mtb:TBMG_03429 no Di-trans-poly-cis-

decaprenylcistransf

erase-like



no 1uehB-19-73-1e-13

mtb:TBMG_03445 no no Taq polymerase,

exonuclease

no 1g19A-27-78-1e-15

mtb:TBMG_03446 no no Ankyrin repeats

(many copies)

no no



















methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-39-229-6e-61


family 65 central

catalytic domain;

Glycosyl hydrolase

family 65, N-terminal

domain; Glycosyl

hydrolase family 65, C-

terminal domain;

Trehalose and maltose

hydrolases (possible

phosphorylases)


and metabolism]

Glycoside

hydrolase, family

65, C-terminal;

Glycoside

hydrolase, family

65, central catalytic;

Glycoside

hydrolase, family

65, N-terminal; Six-


like; Glycoside

hydrolase-type

carbohydrate-

binding; Maltose

phosphorylase/glyc

osyl

hydrolase/vacuolar

acid trehalase

Glycosyl hydrolase


domain ; Glycosyl

hydrolase family 65

central catalytic

domain ; Glycosyl

hydrolase family 65,

C-terminal domain

Trehalose and

maltose

hydrolases

(possible

phosphorylases)

no


aminotransferase

(AAT) superfamily

(fold type I) of

pyridoxal phosphate

(PLP)-dependent

enzymes;

DegT/DnrJ/EryC1/StrS

aminotransferase

family;

DegT/DnrJ/EryC1/

StrS

aminotransferase;

Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain

1; subdomain 2;

Pyridoxal

phosphate-

dependent

transferase, major

domain

DegT/DnrJ/EryC1/Str

S aminotransferase

family

Predicted

pyridoxal

phosphate-

dependent

enzyme

apparently

involved in

regulation of

cell wall

biogenesis

2po3A-26-243-5e-65


NAD(P)(+)-binding

proteins;

NAD(P)-binding

domain

FAD-NAD(P)-binding no 1q1rA 16 96 2e-20

mtb:TBMG_03455 Formyltransferase,

catalytic core domain

Formyl transferase,

N-terminal;

Methionine tRNA

Formyltransferase-

like

Formyl transferase Methionyl-

tRNA

formyltransferas

e

no

mtb:TBMG_03464 no no Vta1 like no no

mtb:TBMG_03466 no no no no 1hz4A-12-45-2e-05

mtb:TBMG_03472 Inactive homolog of

metal-dependent

proteases, putative

molecular chaperone

[Posttranslational



Peptidase M22,

glycoprotease

Glycoprotease family Inactive

homologs of

metal-dependent

proteases,

putative

molecular

chaperones

2a6aA -26-91-1e-19

mtb:TBMG_03478 no no Alcohol

dehydrogenase

GroES-associated

no no

mtb:TBMG_03481 B.subtilis YXKO

protein; YjeF-related

protein N-terminus;

carbohydrate

kinase-related;

YjeF-related

protein, N-terminal

YjeF-related protein

N-terminus ;

Carbohydrate kinase

Predicted sugar

kinase

2ax3A-27-393-1e-110











mtb:TBMG_03482 no no no Membrane

transporters of

cations and

cationic drugs

no

mtb:TBMG_03483 no no Tripartite

tricarboxylate

transporter TctB

family

no no

mtb:TBMG_03486 no no Alpha/beta hydrolase

family

no 2fx5A-19-78-2e-15

mtb:TBMG_03487 no no Proteins of 100

residues with WXG

no 1jhnA-27-37-0.010

mtb:TBMG_03494 type VII secretion-

associated protein,

Rv3446c family, C-

terminal domain

Type VII secretion

system Rv3446c

no no 2b5uA-17-37-0.007


system EccD

WXG100 protein

secretion system

(Wss), protein YukD

no 2b5uA-20-43-2e-04

mtb:TBMG_03498 bacterial membrane

proteins.

Type VII secretion

system EccB

no no no

mtb:TBMG_03502 Sodium:solute

symporter family

no no no 1vr5A-29-38-0.003


monoxygenases; F420-

dependent

oxidoreductase,

MSMEG_4879 family;

Luciferase-like,

F420-dependent

oxidoreductase

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

3c8nA-16-69-2e-12

mtb:TBMG_03514 associated to the N-

terminus of the HNH

endonuclease domain

no MIF4G domain no no

mtb:TBMG_03515 HNH nucleases;

associated to the N-

terminus of the HNH

endonuclease

HNH nuclease HNH endonuclease no 2qgpB-17-36-0.009



conserved barrel


superfamily

Cupin 1; Cupin,

RmlC-type; Cupin

2, conserved barrel;


fold

Cupin domain Mannose-6-

phosphate

isomerase

no


2 (NTF2-like)

superfamily

no SnoaL-like domain no 2chcA-98-166-1e-42

mtb:TBMG_03525 patatin-related protein; Patatin/Phospholipa

se A2-related; Acyl

transferase/acyl

hydrolase/lysophos

pholipase

Patatin-like

phospholipase

no no


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT;

O-acyltransferase,

WSD1, N-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA -27- 40- 8e-04


biogenesis protein


no membrane protein no no

mtb:TBMG_03529 LppP/LprE lipoprotein; no LppP/LprE lipoprotein no no



















transcriptional

attenuator domain;

LytR cell envelope-


attenuator;

Cell envelope-

related

transcriptional

attenuator


transcriptional

attenuator domain ;

LytR cell envelope-


attenuator

Transcriptional

regulator

1uhvA -14 -31 -0.006


YphA

DoxX Predicted

membrane

protein

no


domains;

Transcription

regulator PadR N-

terminal; Winged

helix-turn-helix

transcription

repressor DNA-

binding

Transcriptional

regulator PadR-like

family

Predicted

transcriptional

regulators

2eshA- 30- 89- 3e-19

mtb:TBMG_03538 no no Alphaherpesvirus

glycoprotein E ;

Central core of the

bacterial effector

protein AvrPto ; SepZ

no no


N-terminal

PE family no no

mtb:TBMG_03558 Acetoacetate

decarboxylase (ADC);

no Acetoacetate

decarboxylase (ADC)

no 3c8wA- 17- 128- 1e-

30

mtb:TBMG_03563 NHL repeat NHL repeat; Six-

bladed beta-

propeller, TolB-

like;

NHL repeat no 1rwiA-46-201-2e-52

mtb:TBMG_03387 acetoin dehydrogenase

E2 subunit

dihydrolipoyllysine-

residue

acetyltransferase;

Provisional


family

Predicted

hydrolases or

acyltransferases

(alpha/beta

hydrolase

superfamily)

1iupA-19-143-2e-35

mtb:TBMG_03406 no no FxsA cytoplasmic

membrane protein

no no



system;

Bacteriophage P1,

prevent-host-death

protein

Antitoxin Phd_YefM,


system

Uncharacterized

ACR

2a6qA-44-106-7e-25

mtb:TBMG_03409 Plasmid stabilisation

system protein;

Addiction module

toxin, Txe/YoeB

Plasmid encoded toxin

Txe

no 2a6sB -45-116-2e-27


domain (FHA)

Forkhead-

associated (FHA)

domain;

SMAD/FHA

domain


containing

proteins

1uhtA-22-79-2e-16

mtb:TBMG_03412 Pentapeptide repeats

containing protein

Pentapeptide repeat Pentapeptide repeats Uncharacterized

low-complexity

proteins

2bm5A-100-181-6e-47

mtb:TBMG_03414 no no Levivirus coat protein no no

mtb:TBMG_03416 Histidine kinase-like

ATPases; Signal

transduction histidine

kinase [Signal

transduction

mechanisms]

ATPase-like, ATP-

binding domain;

HAMP linker

domain

HAMP domain ;

Histidine kinase-,

DNA gyrase B-, and

HSP90-like ATPase

Signal

transduction

histidine kinase

no


N-terminal

PE family no no


















phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

like, FMN-binding

domain; IPR019966

F420-dependent

enzyme, PPOX

class, family

Rv3369

Pyridoxamine 5'-

phosphate oxidase

no 2aq6A-25-78-9e-16

mtb:TBMG_03429 no Di-trans-poly-cis-

decaprenylcistransf

erase-like



no 1uehB-19-73-1e-13

mtb:TBMG_03445 no no Taq polymerase,

exonuclease

no 1g19A-27-78-1e-15

mtb:TBMG_03446 no no Ankyrin repeats

(many copies)

no no


methyltransferase;

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-39-229-6e-61


family 65 central

catalytic domain;

Glycosyl hydrolase


domain; Glycosyl

hydrolase family 65, C-

terminal domain;

Trehalose and maltose

hydrolases (possible

phosphorylases)


and metabolism]

Glycoside

hydrolase, family

65, C-terminal;

Glycoside

hydrolase, family

65, central catalytic;

Glycoside

hydrolase, family

65, N-terminal; Six-


like; Glycoside

hydrolase-type

carbohydrate-

binding; Maltose

phosphorylase/glyc

osyl

hydrolase/vacuolar

acid trehalase

Glycosyl hydrolase


domain ; Glycosyl

hydrolase family 65

central catalytic

domain; Glycosyl

hydrolase family 65,

C-terminal domain

Trehalose and

maltose

hydrolases

(possible

phosphorylases)

no


aminotransferase

(AAT) superfamily

(fold type I) of

pyridoxal phosphate

(PLP)-dependent

enzymes;

DegT/DnrJ/EryC1/StrS

aminotransferase

family;

DegT/DnrJ/EryC1/

StrS

aminotransferase;

Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain

1; Pyridoxal

phosphate-

dependent

transferase, major

region, subdomain

2; Pyridoxal

phosphate-

dependent

transferase, major

domain

DegT/DnrJ/EryC1/Str

S aminotransferase

family

Predicted

pyridoxal

phosphate-

dependent

enzyme

apparently

involved in

regulation of

cell wall

biogenesis

2po3A-26-243-5e-65


NAD(P)(+)-binding

proteins;

NAD(P)-binding

domain

FAD-NAD(P)-binding no 1q1rA-16-96-2e-20









mtb:TBMG_03455 Formyltransferase,

catalytic core domain;

Formyl transferase,

N-terminal;

Methionine tRNA

Formyltransferase-

like

Formyl transferase Methionyl-

tRNA

formyltransferas

e

no

mtb:TBMG_03464 no no Vta1 like no 2e70A-23-47-4e-06

mtb:TBMG_03466 no no no no 1hz4A-12-45-2e-05

mtb:TBMG_03472 Inactive homolog of

metal-dependent

proteases, putative

molecular chaperone

[Posttranslational



Peptidase M22,

glycoprotease

Glycoprotease family Inactive

homologs of

metal-dependent

proteases,

putative

molecular

chaperones

2a6aA-26-91-1e-19

mtb:TBMG_03478 no no Alcohol

dehydrogenase

GroES-associated

no no

mtb:TBMG_03481 B.subtilis YXKO

protein; YjeF-related

protein N-terminus

carbohydrate

kinase-related;

YjeF-related

protein, N-terminal;

Carbohydrate

kinase, predicted,

conserved site

YjeF-related protein

N-terminus ;

Carbohydrate kinase

Predicted sugar

kinase

2ax3A-27-393-1e-110

mtb:TBMG_03482 no no no Membrane

transporters of

cations and

cationic drugs

no

mtb:TBMG_03483 no no Tripartite

tricarboxylate

transporter TctB

family

no no

mtb:TBMG_03486 no no Alpha/beta hydrolase

family

no 2fx5A-19-78-2e-15


residues with WXG

no 1jhnA-27-37-0.010

mtb:TBMG_03494 type VII secretion-

associated protein,

Rv3446c family, C-

terminal domain

Type VII secretion

system Rv3446c

no no 2b5uA-17-37-0.007

mtb:TBMG_03496 Ubiquitin-like proteins; Type VII secretion

system EccD

WXG100 protein

secretion system

(Wss), protein YukD

no 2b5uA-20-43-2e-04

mtb:TBMG_03498 no Type VII secretion

system EccB

no no no

mtb:TBMG_03502 Sodium:solute

symporter family;

no no no 1vr5A -29- 38- 0.003


monoxygenases; F420-

dependent

oxidoreductase,

MSMEG_4879 family

Luciferase-like,

F420-dependent

oxidoreductase,

MSMEG4141

Luciferase-like

monooxygenase

Coenzyme

F420-dependent

N5,N10-

methylene

tetrahydrometha

nopterin

reductase and

related flavin-

dependent

oxidoreductases

3c8nA-16-69-2e-12

mtb:TBMG_03514 associated to the N-

terminus of the HNH

endonuclease domain

no MIF4G domain no no

mtb:TBMG_03515 HNH nucleases;

associated to the N-

terminus of the HNH

endonuclease domain

HNH nuclease HNH endonuclease no 2qgpB-17-36-0.009


















mtb:TBMG_03519 Cupin domain; Cupin 1; Cupin,

RmlC-type; Cupin

2, conserved barrel;


fold

Cupin domain Mannose-6-

phosphate

isomerase

no


2 (NTF2-like)

superfamily

no SnoaL-like domain no 2chcA-98-166-1e-42

mtb:TBMG_03525 patatin-related protein Patatin/Phospholipa

se A2-related; Acyl

transferase/acyl

hydrolase/lysophos

pholipase

Patatin-like

phospholipase

no no


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

O-acyltransferase,

WSD1, C-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA-27-40-8e-04


biogenesis protein


no no no no

mtb:TBMG_03529 LppP/LprE lipoprotein; no LppP/LprE lipoprotein no no


transcriptional

attenuator domain;

LytR cell envelope-


attenuator;

Cell envelope-

related

transcriptional

attenuator


transcriptional

attenuator domain ;

LytR cell envelope-


attenuator

Transcriptional

regulator

1uhvA-14-31-0.006


YphA

DoxX Predicted

membrane

protein

no


domains

Transcription

regulator PadR N-

terminal; Winged

helix-turn-helix

transcription

repressor DNA-

binding

Transcriptional

regulator PadR-like

family

Predicted

transcriptional

regulators

2eshA-30 -89-3e-19

mtb:TBMG_03538 no no Alphaherpesvirus

glycoprotein E;

Central core of the

bacterial effector

protein AvrPto ; SepZ

no no


N-terminal

PE family no no

mtb:TBMG_03558 Acetoacetate

decarboxylase (ADC)

Acetoacetate

decarboxylase beta

barrel domain

Acetoacetate

decarboxylase (ADC)

no 3c8wA-17-128-1e-30

mtb:TBMG_03563 NHL repeat NHL repeat; Six-

bladed beta-

propeller, TolB-

like;

NHL repeat no 1rwiA-46-201-2e-52

mtb:TBMG_03567 no no O-methyltransferase no 1fp2A-22-37-0.005

mtb:TBMG_03568 Sulfotransferase family; Sulfotransferase

domain

Sulfotransferase

family

no 1texD-12-90-9e-19

mtb:TBMG_03581 SAV4209 is a

Streptomyces

avermitilis protein with

a hot dog fold that is

similar to those of (R)-

specific enoyl-CoA

hydratase, the

peroxisomal Hydratase-

Dehydrogenase-

no MaoC like domain no no

















Epimerase (HDE)

protein

mtb:TBMG_03582 (R)-hydratase [(R)-

specific enoyl-CoA

hydratase; Predicted

nucleic-acid-binding

protein containing a

Zn-ribbon

OB-fold, C-terminal Metal-binding domain

of MaoC dehydratase;

DUF35 OB-fold

domain

Predicted

nucleic-acid-

binding protein

containing a Zn-

ribbon

no


dependent

nitroreductase;

FMN-binding split

barrel-related

no no 2fg9A-11-42-1e-04

mtb:TBMG_03737 RDD family RDD RDD family Uncharacterized

membrane

protein/domain

no

mtb:TBMG_03741 Glutamate-cysteine

ligase family

no Glutamate-cysteine

ligase family 2(GCS2)

no 2gwdA-17-246-5e-66


dependent

methyltransferases

(SAM or AdoMet-

MTase), class I

Thiopurine S-

methyltransferase

Thiopurine S-

methyltransferase

(TPMT)

SAM-dependent

methyltransferas

es

2i6gB- 19 -95 -2e-20


aminotransferase

(AAT) superfamily

(fold type I) of

pyridoxal phosphate

(PLP)-dependent

enzymes

Aminotransferase,

class V/Cysteine

desulfurase;

Pyridoxal

phosphate-

dependent

transferase

Aminotransferase

class-V

Cysteine

sulfinate

desulfinase/cyst

eine desulfurase

and related

enzymes

1t3iA- 20- 507 -1e-144

mtb:TBMG_03746 Formylglycine-


enzyme;

Formylglycine-

generating

sulphatase enzyme

domain; C-type

lectin fold

DinB superfamily ;

Formylglycine-


enzyme

Uncharacterized

BCR

2q17E- 28 -232- 6e-62

mtb:TBMG_03748 PknH-like extracellular

domain

no PknH-like

extracellular domain

no no

mtb:TBMG_03758 no Restriction

endonuclease, type

II-like

no no 1cw0A-18-41-4e-04

mtb:TBMG_03760 YbaB/EbfC DNA-

binding family

no YbaB/EbfC DNA-

binding family

Uncharacterized

BCR

1pugA-37-97-1e-21



lC (SRPBCC) ligand-

binding domain

superfamily

Polyketide

cyclase/dehydrase;

START-like

domain


dehydrase and lipid

transport

no 2rerA-17-41-1e-04

mtb:TBMG_03763 FAD binding domain;

FAD/FMN-containing

dehydrogenases

[Energy production and

conversion]

FAD linked

oxidase, N-

terminal; FAD-

linked oxidase-like,

C-terminal

FAD binding domain FAD/FMN-

containing

dehydrogenases

1w1oA-19-199-8e-52


aminotransferase

(AAT) superfamily

(fold type I) of

pyridoxal phosphate

(PLP)-dependent

enzymes.

Pyridoxal

phosphate-

dependent

transferase;

Aminotransferase,

putative

Alanine-glyoxylate

amino-transferase

Transcriptional

regulators

containing a

DNA-binding

HTH domain

and an

aminotransferas

1vp4A-17-396-1e-111














e domain (MocR

family) and their

eukaryotic

orthologs

mtb:TBMG_03778 Members of the Nudix

hydrolase superfamily

catalyze the hydrolysis

of NUcleoside

DIphosphates linked to

other moieties, X.

Enzymes belonging to

this superfamily require

a divalent cation, such

as Mg2+ or Mn2+, for

their activity and

contain a highly

conserved 23-residue

nudix motif

(GX5EX7REUXEEXG

U, where U = I, L or

V), which functions as

a metal binding and

catalytic site.

NUDIX hydrolase

domain

NUDIX domain NTP

pyrophosphohyd

rolases

including

oxidative

damage repair

enzymes

1ktgA- 21 -92 -3e-20


Acyl-CoA


no Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no no

mtb:TBMG_03780 Adenosine specific

kinase;

Adenosine specific

kinase

Adenosine specific

kinase

Uncharacterized

ACR

1vggA-57-271-3e-74

mtb:TBMG_03782 no no Orbivirus outer capsid

protein VP5

no 2oauA-20-32-0.004


Acyl-CoA


acyltransferase,

WS/DGAT/MGAT

O-acyltransferase,

WSD1, N-terminal;

O-acyltransferase,

WSD1, C-terminal;

Acyltransferase,

WS/DGAT/MGAT

Wax ester synthase-

like Acyl-CoA

acyltransferase

domain

no 2jgpA-14-76-1e-14


BCR

no

mtb:TBMG_03793 no no YtkA-like no 3cj1A -28-33-0.010

mtb:TBMG_03794 no no PIN domain no no

mtb:TBMG_03798 putative tRNA

adenosine deaminase-

associated protein

tRNA adenosine

deaminase-

associated protein,

putative

no no no

mtb:TBMG_03800 Putative glycolipid-

binding

no Putative glycolipid-

binding

Uncharacterized

BCR

2h1tA-26-215-8e-57

mtb:TBMG_03805 no no SPW repeat no no

mtb:TBMG_03811 Photosystem II reaction

centre W protein

(PsbW);

Glycoside

hydrolase,

subgroup, catalytic

domain

Bacterial Ig-like

domain (group 4)

no 1jfxA-20-72-2e-13


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-43-220-2e-58















2 (NTF2-like)

superfamily

no SnoaL-like domain no 1oh0B-18-48-7e-07

mtb:TBMG_03814 no no Talin, middle domain ;

Mu B transposition

protein, C terminal

no no

mtb:TBMG_03818 no no Helix-turn-helix

domain

no no


protein

Mycothiol-

dependent

maleylpyruvate

isomerase, metal-

binding domain

Mycothiol

maleylpyruvate


domain

no 2nsfA- 12- 47- 5e-06

mtb:TBMG_03826 no no Cuticle protein 7

isoform family

no 2b5uA-21-37-1e-04

mtb:TBMG_03827 no no ubiquitin-like domain no no

mtb:TBMG_03832 no no no no 1wrbA-16-55-3e-08


family A (GT-A)

includes diverse

families of glycosyl

transferases with a

common GT-A type

structural fold.;

Peptidase family M23;

Glycosyltransferases

involved in cell wall

biogenesis [Cell


outer membrane]

Glycosyl

transferase, family

2; Duplicated

hybrid motif;

Peptidase M23


family 2 ; Peptidase

family M23

Membrane

proteins related

to

metalloendopept

idases

2gu1A-23-183-6e-47


methyltransferase;

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA- 38- 222- 5e-59

mtb:TBMG_03836 GtrA-like protein GtrA-like protein GtrA-like protein Uncharacterized

membrane

protein

no


superfamily;

no Beta-lactamase

superfamily domain

Metal-dependent

hydrolases of

the beta-

lactamase

superfamily III

1y44A -23- 133- 8e-32

mtb:TBMG_03849 Cutinase; Cutinase Cutinase no 2czqA-17-99-1e-21

mtb:TBMG_03854 PAP2_like proteins, a

super-family of

histidine phosphatases

and vanadium

haloperoxidases,

Phosphatidic acid

phosphatase type

2/haloperoxidase;

Phosphatidic acid

phosphatase/chloro

peroxidase, N-

terminal

PAP2 superfamily Membrane-

associated

phospholipid

phosphatase

1d2tA-16-82-1e-16

mtb:TBMG_03858 Peptidoglycan

recognition proteins

(PGRPs); LGFP repeat;

protein potentially

involved in

peptidoglycan

biosynthesis [Cell


outer membrane]

N-acetylmuramoyl-

L-alanine amidase

domain;

Peptidoglycan

recognition protein

family domain,

metazoa/bacteria;

LGFP

N-acetylmuramoyl-L-

alanine amidase ;

LGFP repeat

no 1yckA -29- 192- 2e-49
















biogenesis protein


no Prokaryotic

cytochrome b561

no no

mtb:TBMG_03869 PE-PPE domain; PE-PPE, C-terminal PE-PPE domain no 2czqA- 13- 42- 2e-04

mtb:TBMG_03878 no no Colicin V production

protein

no no

mtb:TBMG_03881 Septum formation; no Septum formation no no

mtb:TBMG_03882 Possibl zinc metallo-

peptidase

no Possibl zinc metallo-

peptidase

no 2ejqB -22- 38- 5e-04

mtb:TBMG_03885 no FMN-binding split

barrel-related

no no 2arzA-14-76-8e-15

mtb:TBMG_03889 no no Double zinc ribbon ;

Hydrogenase

expression/synthesis

hypA family

no no

mtb:TBMG_03890 no no Alphavirus core

protein

no no

mtb:TBMG_03893 no no Biotin and Thiamin

Synthesis associated

domain

no no

mtb:TBMG_03897 no no Conserved membrane

protein YqhR

Predicted

membrane

protein

no

mtb:TBMG_03898 Fimbrial protein Lambda repressor-

like, DNA-binding

Helix-turn-helix ;

ActA Protein

no 1b0nA-21-37-0.001

mtb:TBMG_03899 no no no no 1wdkB-25-36-0.007

mtb:TBMG_03900 no no no no 2b5uA-22-35-0.006

mtb:TBMG_03909 Antiactivator of



motility]

Cobyrinic acid a,c-

diamide synthase

AAA domain no 1ionA-19-156-5e-39

mtb:TBMG_03911 no Forkhead-

associated (FHA)

domain;

SMAD/FHA

domain; Lambda

repressor-like,

DNA-binding

FHA domain; Helix-

turn-helix

no 1uhtA-24-66-1e-11

mtb:TBMG_03913 WXG100 super family ESX-1 secretion-

associated protein

EspC;

no no no

mtb:TBMG_03914 ESX-1_EspG super

family

no EspG family no no

mtb:TBMG_03915 ESX-1_EspG super

family

no EspG family no no

mtb:TBMG_03916 AAA+ (ATPases


variety of cellular


CbxX/CfqX;

ATPase, AAA+

type, core; ATPase,

AAA-type, core

ATPase family

associated with

various cellular

activities (AAA)

ATPases of the

AAA+ class


system EccB

no no no


Nucleoside

Triphosphate


secretion protein

EccCa;

Cell division

protein

FtsK/SpoIIIE; Type

VII secretion

system EccCa


segregation

ATPase

FtsK/SpoIIIE

and related

proteins

2iutA- 19- 327- 4e-90


Nucleoside

Triphosphate


secretion protein

EccCb;

Cell division

protein

FtsK/SpoIIIE;

AAA+ ATPase

domain; Type VII

secretion system

EccCb


segregation

ATPase

FtsK/SpoIIIE

and related

proteins

2iusD-16-254-3e-68
























N-terminal

PE family no no


system EccD;

YukD-like

WXG100 protein

secretion system

(Wss), protein YukD

no 2b5uA-19-50-8e-09


system EccD;

YukD-like

WXG100 protein

secretion system

(Wss), protein YukD

no 2b5uA- 19- 50- 8e-09


residues with WXG

no 2pziA -11- 62- 4e-12

mtb:TBMG_03928 YbaB/EbfC DNA-

binding family

YbaB-like DNA-

binding protein

YbaB/EbfC DNA-

binding family

no 1pugA-18-44-1e-05

mtb:TBMG_03929 no no PPE family no 2pziA-9-38-0.004


system protein

EccE

no no no


system protein

EccE

Nuclear receptor

coactivator

no 1s5jA-9-31-0.005


system EccD;

YukD-like

WXG100 protein

secretion system

(Wss), protein YukD

no 2ojrA-30-35-3e-04

mtb:TBMG_03936 Antiactivator of



motility]

no AAA domain ATPases

involved in

chromosome

partitioning

1g3qA-17-164-2e-41

mtb:TBMG_03937 EspG family no EspG family no no


Nucleoside

Triphosphate


secretion protein

EccCa; type VII

secretion protein EccCb

Cell division

protein

FtsK/SpoIIIE; Type

VII secretion

system EccCa;

Type VII secretion

system EccCb


segregation

ATPase

FtsK/SpoIIIE

and related

proteins

no


system EccB

no no no

mtb:TBMG_03944 lysozyme_like domain Lytic

transglycosylase-

like, catalytic;

Lysozyme-like

domain

Transglycosylase SLT

domain

no no

mtb:TBMG_03947 no no YbaK / prolyl-tRNA

synthetases associated

domain

no 2pziA-8-43-1e-04

mtb:TBMG_03949 no no Anti-sigma-K factor

rskA; Thiamine

pyrophosphokinase C

terminal ; Wnt and

FGF inhibitory

regulator

no no

mtb:TBMG_03950 no no no no 2csbA-16-36-0.002

mtb:TBMG_03951 no no Baculovirus

polyhedron envelope

protein, PEP, C

terminus

no no

mtb:TBMG_03954 no no no no 1yo8A-25-73-2e-14

mtb:TBMG_03956 Diadenosine

hexaphosphate (Ap6A)

hydrolase is a member

of the Nudix hydrolase

superfamily

NUDIX hydrolase

domain

NUDIX domain NTP

pyrophosphohyd

rolases

including

oxidative

damage repair

enzymes

no





















mtb:TBMG_03957 no no Carboxypeptidase

regulatory-like

domain

no no

mtb:TBMG_03960 no no Anti-sigma-K factor

rskA

no no

mtb:TBMG_03964 no no no no 2cntA-25-37-0.003

mtb:TBMG_03970 Haemolytic domain no Haemolytic domain Uncharacterized

ACR

no

mtb:TBMG_03974 no no SPW repeat no no


methyltransferase

no no no 2uyoA- 29- 106 -1e-24

mtb:TBMG_03981 Tryptophan synthase

beta superfamily (fold

type II

no Mycothiol

maleylpyruvate


domain; SAM like

domain present in

kinase suppressor

RAS 1; 60s Acidic

ribosomal protein;

Putative RNA

methylase family;

YbaB/EbfC DNA-

binding family

Tryptophan

synthase beta

chain

no

mtb:TBMG_03985 no no no no

Phospholipid

methyltransferase


methyltransferase;

no no no 2uyoA- 32- 99- 2e-22


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA -43 -178 -1e-45

mtb:TBMG_04006 Histidine kinase,

Adenylyl cyclase,

Methyl-accepting

protein, and

Phosphatase (HAMP)

domain; Histidine

Kinase A

(dimerization/phosphoa

cceptor) domain;

Signal transduction

histidine kinase,

homodimeric

HAMP domain; GGL

domain; His Kinase A

(phospho-acceptor)

domain

Signal

transduction

histidine kinase

2c2aA- 39 -43 -1e-05

mtb:TBMG_04007 no Homeodomain-like;

Winged helix-turn-

helix transcription

repressor DNA-

binding

no Uncharacterized

ACR

2ga1A- 37 -71 -6e-14


Superfamily (MFS)

Major facilitator

superfamily

domain, general


Major Facilitator

Superfamily

Permeases of the

major facilitator

superfamily

1pw4A -19- 259- 8e-

70

mtb:TBMG_04013 Peptidase family M22 Duplicated hybrid

motif; Peptidase

M23

Peptidase family M22 Membrane

proteins related

to

metalloendopept

2hsiB -22 -112- 4e-26















idases

mtb:TBMG_04018 no no no no 2oo3A -26 -37- 0.010


N-terminal

PE family no no

mtb:TBMG_04026 no no Thiamine

pyrophosphokinase C

terminal

no no


Golgi protein

SNARE associated

Golgi protein

SNARE associated

Golgi protein

no no


Golgi protein

no no Uncharacterized

ACR

no

mtb:TBMG_04032 no Dimeric alpha-beta

barrel;

Transcription

regulator AsnC-

type, C-terminal

AsnC family no 2qz8A-23-43-2e-05

mtb:TBMG_04033 no no PEP-utilising enzyme,

N-terminal

no no

mtb:TBMG_04047 no no membrane protein no no

mtb:TBMG_04054 no no no no 2pziA-11-38-4e-05


methyltransferase

Leucine carboxyl

methyltransferase;

S-adenosyl-L-

methionine-

dependent

methyltransferase,

putative

Leucine carboxyl

methyltransferase

O-

Methyltransferas

e involved in

polyketide

biosynthesis

2uyoA-45-225-5e-60

mtb:TBMG_04060 Trm112p-like protein; no Trm112p-like protein Uncharacterized

BCR

2jnyA-52-75-4e-15

mtb:TBMG_04062 no no Transposase domain;

PT repeat

no no

mtb:TBMG_04067 Nucleotidyltransferase

(NT) domain of RelA-

and SpoT-like ppGpp

synthetases and

hydrolases.

RelA/SpoT Region found in RelA

/ SpoT proteins

Uncharacterized

BCR

2be3A- 20- 161 -1e-40


Nucleoside

Triphosphate

Hydrolases

AAA+ ATPase

domain

AAA ATPase domain ATP-dependent

Zn proteases

1in4A -16- 54- 3e-08

mtb:TBMG_04076 no no no no 1s7iA-23-41-7e-05

mtb:TBMG_04078 no no Lysosome-associated

membrane

glycoprotein (Lamp)

no no

mtb:TBMG_04080 found associated to the

N-terminus of the HNH

endonuclease domain

no no no no

mtb:TBMG_04085 no no HipA-like C-terminal

domain

no no

mtb:TBMG_04088 no ATPase, P-type,

K+-transporting, F

F subunit of K+-

transporting ATPase

no no




















subunit (Potass_KdpF)

mtb:TBMG_04093 no no no Lactoylglutathio

ne lyase and

related lyases

1twuA-27-37-0.002


phosphate (PNP)


FMN-binding split

barrel-related;

Pyridoxamine 5'-

phosphate oxidase-

related

Pyridoxamine 5'-

phosphate oxidase

no 3cp3A- 41- 107- 5e-25

mtb:TBMG_04101 no no Motilin/ghrelin no no

mtb:TBMG_04106 no PE-PGRS family,

N-terminal

PE family no no


N-terminal

PE family no no


N-terminal

PE family no no







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Table 1. Predicted Structures and functions of ... · Table 1. Predicted Structures and functions...

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