Annual Report 2014

2

Table of contents

3 Foreword 4 2014 Highlights 6 On the Road to a New Charité 12 2014 in Numbers 16 Health Services 17 Research 18 Education and Teaching | Training 19 Organizational Structure 20 Overview of Medical Facilities and Institutes Selected Publications 2014

Legal notice Publisher Corporate Communications Division, Charité – Universitätsmedizin Berlin

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Zentrale Mediendienstleistungen, Charité – Universitätsmedizin Berlin

Photos Wiebke Peitz, Zentrale Mediendienstleistungen, Charité – Universitätsmedizin Berlin

Beatrice Staib (page 4, middle left), Jens Jeske (page 4, middle right),

Randy Tarango (page 5, bottom left), Stephan Baumann (page 5, bottom left),

Schweger Architekten (page 8, top left),

Sabine Gudath (page 8, top right), picture alliance / dpa (page 10, top left)

Frontispiece: Construction work on the new façade of the main ward (CCM)

3

Professorial appointments, construction projects, the Ebola virus, staffing changes and positive

annual results: these are the keywords that best describe 2014 at the Charité – Universitätsme-

dizin Berlin.

By appointing numerous renowned doctors, the Charité has significantly strengthened its work

in cardiology, tumor and transplantation surgery, gynecology, and sports medicine. In addition,

Prof. Dr. Thomas Südhof, a laureate of the Nobel Prize in Physiology or Medicine, will be spending

three years with the Charité as an Einstein BIH Visiting Fellow at the Berlin Institute of Health.

There were also changes in key administrative departments. Evelyn Möhlenkamp replaced Hedwig

François-Kettner as Nursing Director in February. The Faculty Council elected Prof. Dr. Axel R. Pries

as Dean in December. He took over from Prof. Dr. Annette Grüters-Kieslich.

The Charité’s largest construction project began in January with the handing over of keys to the

general contractor. The project will fully renovate and modernize the main ward building, which

dates back to 1982. The cornerstone ceremony for the new building that will stand on the eastern

side of the 21-storey ward building was held in September. Berlin’s then mayor, Klaus Wowereit, was

in attendance. Once finished, the building will house operating theaters, intensive care medicine

and emergency medicine.

Campus Charité Mitte is not the only Charité location to be benefiting from building work. The

new emergency diesel generator at Campus Virchow-Klinikum has gone into operation, and the

1960s operating theaters on Campus Benjamin Franklin are undergoing extensive renovations.

The new rooms for the Department of Psychiatry and Psychotherapy have also been completed.

In response to the outbreak of Ebola in West Africa, the Charité has put numerous preparatory

measures in place. Doctors and nurses attended Germany’s biggest isolation unit at Campus

Virchow-Klinikum for intensive, regular training on how to handle a potential emergency.

For many years now, the Charité has been addressing its role in Germany’s National Socialist era.

The GeDenkOrt.Charité – Science and Social Responsibility project is part of these efforts. Last

year, six memorial columns were installed across three of the Charité’s four campuses, displaying

the biographies of employees who were forced into exile.

The Charité enjoyed a successful year in 2014. Focus magazine’s nationwide hospital ranking

crowned it Germany’s Best Hospital for the third year in a row. It also closed 2014 with a positive

operating result for the fourth year running. This year’s profits totaled €7.6 million. Given the in-

creasingly difficult financial situation facing university hospitals in Germany, we are very pleased

with this successful outcome. It would not have been possible without the spirit of cooperation

and the daily efforts of the some 16,800 employees working throughout the Charité. For this, we

would like to extend our warmest thanks. In 2015, our shared commitment will continue to be the

basis for developing the Charité further and securing its success.

Foreword

Prof. Dr. Karl Max Einhäupl Prof. Dr. Axel R. Pries Matthias Scheller Prof. Dr. Ulrich Frei Chairman of the Board Dean Hospital Director Medical Director

Health sector convenes for high-level meeting: The Charité attends the Medicine and Health congress in Berlin

New Nursing Director: Evelyn Möhlenkamp takes over from Hedwig François-Kettner

Health education for all: The Charité’s XXL Sunday lecture focuses on dementia, cancer, rheumatism and osteoarthritis

Comfort for parents of preemies: Dr. Eckart von Hirschhausen opens a new parents’ room in the neonatology department

Building in Mitte: Cornerstone ceremony marks the start of a new home for surgery, intensive care and emergency medicine

Makeover for the main ward façade: 2,068 aluminum elements give the building a bright new look

Christmas music on every campus: The CharitéBrass-Band plays Christmas songs for staff and patients

Unusual patients: Germany’s health minister, Hermann Gröhe, visits the stuffed toy clinic at the Charité

Germany’s biggest health study: The Charité opens the National Cohort’s Berlin-Mitte study center

Latest clinical diagnostics: High-resolution imaging with three new magnetic resonance imaging systems

Joining forces for university hospitals: The Charité participates in a nationwide campaign week

Charity for Charité: Benefit gala for children with serious chronic and rare diseases

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2014 was an eventful and groundbreaking year for the

Charité – Universitätsmedizin Berlin. Many topics and pro-

jects were initiated or continued and all of them helped to

move the Charité forward. Once again, for example, the

Charité succeeded in attracting renowned doctors and re-

searchers from around the world.

Top-Flight Doctors AppointedProf. Dr. Johann Pratschke became Director of the Depart-

ment for General, Visceral and Transplantation Surgery in

June. This puts Prof. Dr. Patschke, a specialist in tumor and

transplantation surgery, at the head of the largest depart-

ment in the Charité. The role involves leading and restructu-

ring the surgical departments at Campus Virchow-Klinikum

and Campus Charité Mitte.

The Department of Gynecology and the Breast Center also

underwent structural changes. Prof. Dr. Jens-Uwe Blohmer

became the new Director of the Department of Gynecology

at Campus Charité Mitte in September. He also heads the

Charité’s Breast Center at all three locations. The Depart-

ment of Gynecology at Campus Virchow-Klinikum and at

Campus Benjamin Franklin continues to be run by Prof. Dr.

Jalid Sehouli, who became a tenured professor in 2014.

This year also saw three world-renowned cardiologists leave

positions in Europe to take up roles at the Charité and bring

their expertise to its cardiovascular departments. Prof. Dr. Ulf

Landmesser became the new Director of the Department of

Cardiology at Charité Campus Benjamin Franklin in October.

The winter semester saw Prof. Dr. Volkmar Falk take up a pro-

fessorship for cardiac surgery at the Charité in cooperation

with the Deutsches Herzzentrum Berlin (DHZB). He is also

the DHZB’s new Medical Director and heads its Department

of Cardiothoracic and Vascular Surgery. Prof. Dr. Burkert

Pieske came to Berlin in November to serve as Director of

the Department of Cardiology at Campus Virchow-Klinikum

and Director of the Department of Cardiology at the DHZB.

These appointments are also very important from a research

perspective, as the professors will provide a major boost for

the clinical cardiovascular research being performed at the

Berlin Institute of Health. The cross-institutional collabora-

tion between Berlin’s new heart specialists, and closer links

between clinical and experimental research will strengthen

translational medicine in the German capital overall. In their

capacity as teachers, the cardiologists will also make an impor-

tant contribution to training the next generation of doctors.

Raising the Bar in Sports Medicine Olympic doctor Prof. Dr. Bernd Wolfarth was appointed Medical

Director of the new sports medicine department and university

outpatient clinic in September. This means the Charité is one

of the few hospitals in Germany to have an interdisciplina-

ry, clinically oriented university outpatient facility for sports

medicine. Prof. Dr. Wolfarth has also been professor of sports

medicine at Humboldt-Universität zu Berlin since 2014.

New Managers Last year saw further staffing changes at the managerial

level in the Charité. Evelyn Möhlenkamp became the new

Nursing Director and a member of the Charité’s Clinical Cen-

ter Management in February. She takes over from Hedwig

François-Kettner, who stepped down as planned after more

than 30 years in the role. Andrea Schmidt-Rumposch was ap-

pointed Deputy Nursing Director. Prof. Dr. Adelheid Kuhlmey,

Director of the Institute of Medical Sociology and Rehabili-

tation Science, became the new Vice Dean for Education in

May after a vote by the Faculty Council. She took over from

Prof. Dr. Claudia Spies after she stepped down. The exis-

ting Vice Dean for Research, Prof. Dr. Christian Hagemeier,

was confirmed in office. Prof. Dr. Axel R. Pries, Director of

the Institute of Physiology, was elected Dean by the Faculty

Council in December.

On the Road to a New Charité

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He took over from Prof. Dr. Annette Grüters-Kieslich, who had

served as Dean and a member of the Executive Board from

2008 until she stepped down at the end of 2014.

Driving Translation The Berlin Institute of Health (BIH) was set up by the Charité

and the Max Delbrück Center for Molecular Medicine Berlin-

Buch as a facility for pooling their translational research. The

institute is designed to promote the translation of research

findings into clinical application for the benefit of patients,

and to investigate clinical questions in the laboratory. This

makes it the first facility in Germany to adopt a holistic,

systems-medical approach. The BIH successfully launched

its first major research projects and a number of key in-

frastructure measures in 2014. Thanks to support from the

Private Excellence Initiative Johanna Quandt, whose funds

are managed by the Charité Foundation, Prof. Dr. Thomas

Südhof will be spending the next three years at the BIH as

an Einstein BIH Visiting Fellow. A Stanford professor and lau-

reate of the Nobel Prize in Physiology or Medicine, Prof. Dr.

Südhof will be working on a neuroscience project in which he

will investigate how neurons in the brain communicate with

one another and how diseases disrupt this communication.

Master-Plan Projects at all LocationsSome of the Charité’s key construction projects are part

of the master-plan that the Berlin Senate agreed in 2010.

The Senate has made a total of €376.5 million available for

renovating and improving critical structures.

The Charité launched its largest master-plan project in Ja-

nuary 2014 with a symbolic handing over of keys to the ge-

neral contractor, a consortium of Ed. Züblin AG and VAMED

Deutschland. The main ward building at the Mitte location will

be modernized and a new building erected for surgery, inten-

sive care medicine and emergency medicine. Work on gutting

the interior of the 21-story ward building started at the same

time as the removal of the old façade. Work on renovating the

20,500 m2 façade started later in the year, on time and as

planned. The bright new unitized façade features high-quality

insulation that makes for a more energy-efficient building.

The new building on the eastern side of the ward building

is also progressing on schedule and within budget. The cor-

nerstone ceremony was held in September. Some 100 guests

attended the celebrations, among them Klaus Wowereit,

the then mayor of Berlin, and Sandra Scheeres, chair of the

Supervisory Board at the Charité and senator for Education,

Youth and Science. The work on the main ward building also

includes replacing the bridge over Luisenstraße, which con-

nects the ward with the historic campus. The new bridge will

be made of steel and glass and will feature a light, transpa-

rent design. The whole master-plan project is expected to

be completed at the end of 2016.

Last year also saw a great deal of activity on construction

sites at the other locations. Construction teams are hard at

work extensively renovating the 1960s operating theaters on

Campus Benjamin Franklin. The project is being carried out

in two construction phases while work continues in the thea-

ters. This master-plan project, which is also on schedule and

within budget, should be complete in 2016. The new rooms for

the Department of Psychiatry and Psychotherapy on Campus

Benjamin Franklin – also part of the Charité’s master-plan –

were completed in December 2014 and went into use in Janu-

ary 2015. This meant that the Charité could give up another

external location and significantly improve its patient care

structure. The master-plan’s emergency diesel power project

at Campus Virchow-Klinikum was completed in December.

The state-of-the-art high-voltage switchgear is housed in

its own building and is equipped with two emergency diesel

generators that can be used to support the existing power

supply. The commissioning of the system is part of a project

to restructure the site’s entire electricity supply.

On the Road to a New Charité

417

100

Locations

Charité Centers

Hospitals and Institutesalmost

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Germany’s Best HospitalThe German magazine Focus awarded the title of Germany’s

Best Hospital to the Charité when it published its national

hospital ranking in September 2014. The Charité thus suc-

cessfully defended its title, which it has held for the past

few years, and at the same time set new quality standards

for the future. The Focus list is based on Germany’s most

comprehensive quality comparison, which reviews more than

1,000 hospitals across the country. The Charité achieved out-

standing results in most of the 16 areas included in the study.

The Family-Friendly CharitéIn June, the Charité was awarded familiengerechte hochschu-

le (Family-Friendly University) and berufundfamilie (Family-

Friendly Workplace) certification after it successfully completed

the corresponding audits. This was the third time in a row that

it had received the certification, in recognition of its sustainable

initiatives for helping staff combine working and family life. It

received particular praise for giving parents access to a wide

range of childcare options, even in unforeseen situations.

The Charité has expanded its commitment even further and

currently collaborates with six children’s day-care centers.

Flexible working hours for nurses, and formats such as job

sharing and working from home are also well established

at the Charité.

Partnership with VivantesThe Charité and Vivantes are expanding their partnership.

Once Labor Berlin had established itself as a successful joint

venture, work on building the radiotherapy center at the

Vivantes hospital in Friedrichshain also made swift progress.

The shell of the building was completed in December. This

means the project, which is expected to cost €9 million, is

on schedule and within budget. The building should be ready

for use by the middle of 2015. The new rooms will feature

state-of-the-art equipment and technology. The Charité will

be responsible for the medical management of the center.

The aim is to provide optimum patient care by combining a

municipal care structure with university expertise.

Outstanding Surgical AchievementSurgeons successfully reattached the arm of a 30-year-old

man in an operation that lasted around seven hours. The me-

dical team successfully performed a rare macroreplantation

of the right arm, which had been severed eight centimeters

above the elbow. The high quality of the emergency medical

care provided by the paramedics was key to the success of

the operation. The arm’s blood supply was restored just 3.5

hours after the accident. The patient has been making an

excellent recovery. To fully restore the functions of his hand

and fingers, surgeons will have to carry out further operations,

such as transplanting neural tracts. The doctors estimate that

it will take more than two years for the nerves to grow and for

the patient to regain full movement in his hand and fingers.

Robot SurgeonsThe Charité began using the latest generation of the da

Vinci robot for complex surgical interventions in January.

This makes it one of the few hospitals in Berlin and Branden-

burg to have access to this innovative surgical technology.

Numerous new features allow the system to perform opera-

tions with outstanding precision and the utmost safety. It can

drastically reduce the occurrence of unwanted side effects.

In contrast to conventional keyhole surgery, doctors using

the da Vinci system benefit from high-definition 3D vision

and instruments that allow complete freedom of movement.

When operating in tight spaces, such as in urological, thora-

cic and colorectal-cancer surgery, it is especially helpful for

surgeons to have three instrument arms at their disposal

and the ability to guide the camera themselves.

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First Mobile CT ScannerIn May, the Charité became the first hospital in Europe to

have a mobile computer tomography (CT) scanner. The

new device can scan patients while they are undergoing

neurosurgery – and even sitting up. This allows the surgeon

to update important diagnostic 3D data at any time during

surgery and check, for instance, whether a tumor has been

completely removed. The ring-shaped high-tech device also

means that the Charité can now produce 3D images of the

entire spine, and it is faster, gentler and more accurate

than other scanners. Before its arrival, surgery patients

had to be moved to a stationary scanner in the radiology

department before doctors could evaluate the outcome of

the operation.

Cardiac Arrest CenterEach year, over 75,000 people in Germany suffer cardiac

arrest and have to be resuscitated. Just 5,000 of them

survive this dangerous cardiac event. In order to improve

patients’ survival chances, the Charité opened the country’s

first center of excellence for cardiac arrests in July. It de-

livers fast, specialized treatment to those who have been

resuscitated after suffering a cardiac arrest. This involves

quickly identifying the cause of the arrest and rapidly re-

ducing the patient’s body temperature, as this has been

proven to reduce neurological damage. The aim is to use

standardized procedures and treatment in hospitals with

specialized cardiac arrest centers to significantly increase

the number of people who survive a cardiac arrest with a

good neurological prognosis.

Funding for Dedicated StudentsIn April 2014, the Charité awarded 40 new Germany Schol-

arships to selected students pursuing programs in medicine

and dentistry and other health-related fields. In addition to

their outstanding academic achievements, the recipients

also demonstrated a strong commitment to civil society.

They will each benefit from a monthly grant of €300 for

a period of at least one year. The grants are funded by

the German government and private sponsors, who each

provide half of the total.

National CohortThe Charité began participating in the National Cohort in

September, when it opened a study center in Berlin-Mitte.

Entitled “Joint Research for a Healthier Future”, the National

Cohort is Germany’s largest-ever national population study

and will examine around 200,000 people over the next 20

to 30 years. The large-scale project is receiving €210 million

in funding from the German government, the participating

states and the Helmholtz Association. The aim is to improve

research into widespread diseases such as cancer, diabetes

and cardiovascular diseases, so as to enhance their preven-

tion and therapy.

Powerful ResearchThe Charité proved once again in 2014 that it is a research

powerhouse. This was reflected in the decision of the Ger-

man Research Foundation (DFG) to extend two Collaborative

Research Centres / Transregios that are coordinated by the

Charité. The scientists involved are investigating how innate

or acquired immune responses can be used to treat pneu-

monia and cancer. The DFG also approved a new research

group that will spend the next three years investigating which

factors cause bones to heal more slowly in old age.

The faculty applied for DFG funding for five large-scale re-

search devices in 2014. The applications were approved and

the faculty received around €1.2 million from the DFG to

fund the devices.

The German Federal Ministry of Education and Research

(BMBF) is funding the national research group CAPSyS

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(Systems Medicine of Community-Acquired Pneumonia) for

three years. The financing totals €3.8 million. The Charité is

receiving €1.4 million of that for its research into how seri-

ous or fatal forms of pneumonia can be identified early and

what can be done to significantly improve the progression

of the disease.

The Charité is participating in the BMBF’s research network

on mental illnesses. It is involved in seven groups and coordi-

nates the addiction research group. The nationwide research

network is receiving €35 million in funding and will spend

the next four years doing intensive research into the causes,

diagnosis and treatment of mental illnesses.

As part of its nationwide research network, the BMBF is also

funding three large-scale collaborative projects on diseases

of the musculoskeletal system. They are being led by the

Charité. The projects aim to advance research, networking

between experts, and treatment options for conditions such

as rheumatism, osteoporosis and back pain.

The Charité submitted ten successful applications for the

EU’s “Horizon 2020” research and innovation program in

2014. The fields included the neurosciences, cardiology,

gastroenterology, rheumatology, and medical nanotech-

nology. It also received an ERC Starting Grant for medical

psychology.

The Ebola EpidemicThe Ebola epidemic in West Africa was a top issue for the

world and the Charité last year. The university hospital has

set up Germany’s largest isolation unit at Campus Virchow-

Klinikum. Numerous selected medical staff are undergoing

intensive, regular training there so that they will be able

to respond if an emergency does arise. In addition, several

doctors and nurses from the Charité helped treat Ebola pa-

tients in Hamburg and Frankfurt, while others have traveled

to West Africa to work with aid organizations on the ground.

The Ebola epidemic was also the subject of a symposium

that was held at the sixth World Health Summit in October

and organized in cooperation with Germany’s foreign office

and health ministry. International experts and the Ger-

man government’s special envoy for Ebola, Walter Lindner,

used the special event to call for a coordinated approach,

sustainable infrastructure on the ground, and support for

international aid workers. The World Health Summit was

held under the patronage of German chancellor Angela

Merkel, French president François Hollande, and European

Commission president José Manuel Barroso. Around 1,200

international representatives from academia, the private

sector, politics and civil society discussed strategies for

solving the medical challenges facing the world today.

GeDenkOrt.CharitéThe GeDenkOrt.Charité – Science and Social Responsibility

project addresses the role, past and present, of medicine

and science in society. The initiative is designed to help the

institution confront its own past and also to raise awareness

of current ethical dilemmas. Two important elements of this

project were initiated in 2014: the foundation Friede Springer

Stiftung will fund a Medical Humanities guest professorship

at the Charité, and the support organization Freundeskreis

der Charité is helping set up an Info Box to inform the public

about the origins and objectives of the GeDenk.Ort project.

In addition, two memorial columns have now been installed

at each of the hospital locations. The columns bear the na-

mes of the more than 180 employees who are known to

have been forced into exile during the National Socialist era

and provide more detailed information on the lives of six of

these individuals.

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120 Years of PediatricsThe Charité had an important event to celebrate in Novem-

ber: the 120th anniversary of Germany’s first chair for pe-

diatrics, which was established in Berlin in 1894. This date

has always been considered as marking the birth of modern

pediatric and adolescent medicine. Otto Heubner, Germany’s

first full professor of pediatrics, helped turn the field into an

independent academic discipline. Heubner was also director

of the Charité’s children’s hospital, which was founded in

1829. In collaboration with leading doctors and scientists

of his time, Heubner made significant progress in, among

other things, reducing infant mortality. To this day, children

benefit from the close links between research and care in

Berlin. All nine children’s departments at the Charité take a

multiprofessional, interdisciplinary approach to collaborating

on medical care and research.

A Thank-You for Generous Support The Charité relies on donations for many projects that go

beyond its legal obligations to provide medical care. In June,

as a way of expressing its thanks for the generosity of many

dedicated supporters, the Charité laid clinker bricks engraved

with donors’ names at the entrance to the children’s depart-

ments on Campus Virchow-Klinikum. They are designed to

symbolize the shared path to better children’s health. During

the ceremony, Prof. Dr. Karl Max Einhäupl personally thanked

everyone, on behalf of the Executive Board and the depart-

ments, who has helped the Charité in this way.

Help for Seriously Ill ChildrenImproving care for young patients who suffer from serious

chronic and rare diseases is a project that is very close to

the hearts of the staff working in the children’s departments

at the Charité. The Charité wants to do more in this area

and develop an appropriate care structure of a standard

that does not yet exist anywhere in Germany. Particularly

for children with rare diseases, the journey to a diagnosis

alone can be an odyssey that lasts many years and involves

numerous hospital stays and uncertainties. For the Charité’s

plans to succeed, its children’s departments need financial

support from dedicated donors.

The Charity for Charité benefit gala that was held in Decem-

ber raised over €100,000. Jörg Thadeusz was the host for the

evening, which featured a diverse program and a slogan that

called for “better health for our children”. The main event

of the gala was an auction run by lawyer and art enthusiast

Prof. Dr. Peter Raue. The guests included Eva Luise Köhler,

patron of the Alliance for Chronic Rare Diseases (ACHSE),

designer Jette Joop, and Jörg Woltmann, sole shareholder

of the Königliche Porzellan-Manufaktur Berlin (KPM).

Radio Berlin 88.8 also used its 2014 Christmas fundraising

campaign to help improve treatment for children with seri-

ous chronic and rare diseases. Its listeners donated a total

of €127,000 to the project. Anyone who donated €5 or more

took part in a prize draw to win one of 24 premium Berlin-

made products.

The Charité, designer Jette Joop, and KPM also launched

a joint project to support the children’s departments. Joop

created a special winged heart design for 101 KPM Cadre

vases and painted the first one herself. The profits will go to-

wards improving the lives of the Charité’s youngest patients.

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ProfitabilityThe Charité – Universitätsmedizin Berlin comprises around

100 departments and institutes spread across four loca-

tions: Campus Benjamin Franklin, Campus Berlin-Buch,

Campus Charité Mitte and Campus Virchow-Klinikum. The

Charité has a total of about 16,800 employees in medical

care, research and teaching, service, administration, and

third-party funding. This makes the Charité one of the big-

gest employers in the German capital.

In fiscal year 2014, the Charité generated total revenue of

more than €1.5 billion (including investment grants), with

revenue of €848.4 million coming from more than 139,000

inpatient and semi-inpatient cases and over 656,000 out-

patient cases.

On the expenses side, personnel costs represent the largest

item. They totaled €766.2 million, increasing €20.4 million

from the year before. The cost of materials rose €9.7 mil-

lion to €402.8 million. Other operating expenses stood at

€201.0 million, of which €69.4 million was for maintenance.

Net income for fiscal year 2014 was €7.6 million. It is the

fourth consecutive time that the Charité has posted po-

sitive results for the year, and another year of beating

the ambitious target set out in its business plan. It has

thus stayed the course of economic consolidation for yet

another year. The continued economic improvement of

the Charité is largely thanks to the outstanding dedica-

tion of all Charité employees in implementing the pro-

gram of reforms adopted several years ago.They have

enabled the implementation of a comprehensive port-

folio of structural improvements to achieve greater ef-

ficiency. As a result, the Charité managed to offset and

overcompensate for the effects of collective-bargaining

agreements and inflation as well as additional liabilities

resulting from extensive construction work.

InvestmentsThe Charité invested a total of €125.8 million in tangible

fixed assets and intangible fixed assets during the fiscal

year. These investments were funded in large part by the

state of Berlin, with €33.7 million in general investment sub-

sidies from the state being used for teaching, research and

medical care.

2014 in Numbers

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PROFIT AND LOSS STATEMENT

2013 2014 in T€ in T€

Revenue** 816,190 848,444

Changes in inventories -199 25

Subsidies from public funds 197,903 201,801

Other operating income 338,743 359,783

1.352,638 1.410,053

Personnel expenses 745,729 766,158

Cost of materials 393,127 402,802

Interim result 213,781 241,093

Result from subsidized items related to hospital operations 133,370 63,825

Depreciation, amortisation and write-downs 84,935 73,326

Other operating expenses 211,266 200,999

Interim result 50,950 30,594

Financial result -13,277 -16,941

Result from ordinary activities 37,673 13,653

Extraordinary expense 3,959 5,883

Result from taxes 2,588 -183

Net income for the year including special effect 36,303 7,587 of third party funding obligations

Net income for the year without special effect 1,593 7,587 of third party funding obligations

2014 in Numbers

** Revenue is defined as proceeds from hospital services, optional medical services, outpatient ser-vices, and revenues from elective procedures conducted by physicians.

* Figure without special effect; result 2013 including special effect of the dissolution of third party funding obligations: € 36.3 million

8.2 2008 2009 2010 5.2

1.6* 7.6

2011 2012 2013 2014

-19.2 -17,8

-56.6

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BALANCE SHEET

31 Dec 2013 31 Dec 2014 ASSETS in T€ in T€

A. Fixed assets

I. Intangible fixed assets 1,683 4,867

II. Tangible assets 1.129,961 1.161,660

III. Long-term financial assets 3,642 3,663

1.135,286 1.170,190

B. Current assets

I. Inventories 50,475 48,388

II. Receivables and other assets 252,305 257,092

III. Cash-in-hand, state central bank balances, bank balances 86,406 90,436

389,185 395,916

C. Deferred charges 3,862 3,860

1.528,333 1.569,966

EQUITY AND LIABILITIES

A. Equity

1. Capital 164,346 163,665

2. Revenue reserves 1,800 36,510

3. Accumulated losses brought forward -176,016 -174,424

4. Net income 36,303 7,587

26,432 33,339

B. Special reserves for financing fixed assets 930,390 959,539

C. Provisions 326,668 344,582

D. Liabilities 238,002 228,767

E. Deferred income 6,841 3,739

1.528,333 1.569,966

220 Professors4.135 Nursing staff13.100 Charité Staff members* of those

15

CHANGES IN STAFFING LEVELS

ø FT ø FT Development 2013 2014 of fte

Active full-time staff (FT) total 9,609.2 9,502.6 6.2

of those:

Medical services 2,075.7 2,059.6 -16.1

Nursing services 2,437.7 2,411.4 -26.3

Medical-technical services 2,465.7 2,408.4 -57.3

Functional services 1,125.2 1,128.7 3.5

Operating and supply services 369.1 372.8 3.7

Technical services 203.6 202.4 -1.2

Administrative services 778.4 759.6 -18.8

Special services 96.4 100.5 4.1

Staff training services 57.4 59.3 1,9

Inactive full-time staff 1,230.4 1,176.2 -54.3

Active full-time staff (externally funded) 1,548.4 1,554.6 6.2

Full-time staff total 12,388.1 12,233.4 -154.7

Students 302.2 306.1 4.0

Midwife trainees 38.7 37.3 -1.4

Trainees 91.6 91.4 -0.3

Interns 1.7 0.0 -1.7

Personnel

710Administrative staff3.700 Scientists and physicians

31%

69%

* including Berlin Institute of Health; all figures are rounded

16

Health services

2013 2014 total total

Number of officially authorized beds 3,011 3,011

Beds available 3,011 3,011

Utilization rate 83.4 83.4 (average number of available beds in %)

Average occupancy in days 6.05 6.05

Occupancy days 881,981 881,981

Inpatient cases 136,440 136,440

Outpatient cases 637,171 637,171

Memory

Adult autism

Polyposis syndrome

Amyotrophic lateral sclerosis (ALS)

Anaplastology Psoriasis

Muscle disease

Short bowel syndrome

Number of cases and casemix points, in thousands

Clinic Ranking(Focus 20|2014)

SpeCial CONSUlTiNG HOURS

number 1Charité

Age-related macular degenerationSclerodermia

Movement disorders

Early onset arthritis

Transplantation Surgery

Immunodeficiency

2015TOPNATIONALESKRANKENHAUS

DEUTSCHLANDS GRÖSSTER

KRANKENHAUS- VERGLEICH

Ataxia

Consultation for rare diseases

Consultation for rare diseases Hyperhidrosis

0

50

100

150

200

250

200

150

100

50

02005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Inpa

tien

t ca

ses

case

mix

po

ints

159 163174

182187

117127 130 130 133

193198

204

136 139 140

195

136

201

139

17

Research

Development of state consumption subsidies and external revenue

million

euros

300

250

200

150

100

50

0

47.6 million euros German Research Foundation (DFG)

27.7 million euros Industry

34.9 million euros Federal Ministry

13.1 million euros European Union

13.1 million euros Foundations

12.5 million euros Donations and Other1.9 million euros Land of Berlin

150.7 million euros

procured external

funding

Focus of research activities

• Immunological science

• Cardiovascular research

and metabolism

• Neuroscience

• Oncology

• Regenerative therapies

• Rare diseases and genetics

0

50

100

150

200

250

300

2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

255 258251

245 240229

216203

190177

184 189

8897 98

108101 105

116130 127

151 153 148154

195

stat

e gr

ants

exte

rnal

fun

ding

151

199

Collaborative Research Centers, including with host function

12

2Clinical Research Groups

5DFG ResearchGroups

2DFG Graduate Schools

3 Federal Research Ministry Competency Networks

7

53

Excellence projects, including with host function

18

* without Master

December December 2013 2014

Students, total 6,953 6,906

Number of degree courses 17 19

First-year students, total 1,389 1,461

of whom:

Medicine 697 709

Dentistry 102 100

Health science 66 64

Other 524 588

Graduates, total * 771 744

of whom:

Medicine 607 614

Dentistry 84 73

Health science 80 57

OCCUPATIONAL TRAINING Occupational training at the Health Academy

571 traineeships in 8 different healthcare professions Midwifery Healthcare and nursing Healthcare and pediatric nursing Surgical-technical assistant Nutrition assistant Logopedics Physiotherapy Autopsy and preparation assistants

Further qualified occupatients

Medical assistant Animal technician Administrative assistant Dental assistant Biology lab assistant Office assistant Information systems assistant

Education and teaching

Consumer Health Care

Public Health

Standard Medical Studies

Cerebrovascular MedicineDentistry

Health and Society:International Gender Studies Berlin

Medical Neurosciences – International Graduate Program

Molecular Medicine

Reformed Medical Curriculum

UNIVERSITY CURRICULUMEpidemiology Applied Epidemiology

BA in Health Science

Model Medicinal Studies

19

CC1 CC2 CC3 CC4 CC5 CC6 CC7 CC8 CC9

CC10 CC11 CC12 CC13 CC14 CC15 CC16 CC17

EXECUTIVE BOARDChairman of the Executive Board

Prof. Dr. Karl Max Einhäupl

Hospital DirectorMatthias Scheller

Medical DirectorProf. Dr. Ulrich Frei

DeanProf. Dr. Axel R. Pries

Executive Secretary of the BoardDr. Jan Steffen Jürgensen

Clinical Center ManagementMatthias Scheller (Hospital Director)Prof. Dr. Ulrich Frei (Medical Director)

Evelyn Möhlenkamp (Nursing Director)Dr. Helmar Wauer (Hospital Business Director)

Faculty BoardProf. Dr. Axel R. Pries (Dean)Prof. Dr. Christian Hagemeier

(Vice Dean for Research)Prof. Dr. Adelheid Kuhlmey (Vice Dean for Education)

Fabian Hempel (Faculty Business Director)

Research

Thomas Gazlig

Study Affairs

Burkhard Danz

Central Academic and International

Academic AffairsDr. Mathias John

Corporate Controlling

Roland Kurney

Strategic Corporate

DevelopmentMatthias

Wiemann (acting)

Human Resources

Christof Schmitt

Corporate Communications

Uwe Dolderer

IT

Helmut Greger

Legal Services

Christof Schmitt

Technologyand Operations

Toralf Giebe

Academy

Dr. Marianne RabeCarsta Prütz

Finance andPurchasing

Dr. Alexander Hewer

Buildings and Grounds Management

Christian Kilz

Office for Negotiations with Health Insurance

CompaniesCarsta Prütz

CHARITÉCENTERS

BUSINESS DIVISIONS

SPIN-OFFS AND HOLDINGSZTB Zentrum für Transfusionsmedizin und Zelltherapie Berlin gemeinnütziger GmbH

Labor Berlin – Charité Vivantes Services GmbH

Labor Berlin – Charité Vivantes GmbH

Charité CFM Facility Management GmbH

CRO Charité Research Organisation GmbH

Charité Healthcare Services GmbH

Charité Physiotherapie- und Präventionszentrum GmbH

Ambulantes Gesundheitszentrum der Charité GmbH

Medizinisches Versorgungszentrum der Charité Mitte GmbH

WHS Foundation GmbH

Medical Faculty SenateChairman: Prof. Dr. Peter-André Alt and Prof. Dr. Jan-Hendrik Olbertz

Office: Dr. Gerda Fabert

Supervisory BoardChairwoman: Sandra Scheeres

Office of the Supervisory Board: Dr. Jan Steffen Jürgensen

Faculty CouncilChairman:

Prof. Dr. Axel R. Pries

Office: Heike Stein

Organizational structures

CorporateGovernance

Marc Deffland

HospitalManagement

Marie le Claire

Last update:February 2015

Pharmacy

Dr. Susan Bischoff

20

Overview of the clinics and institutes

CC1 CharitéCenter for Health and Human Sciences Scientific Director Prof. Dr. Adelheid Kuhlmey +49 30 450 529 171 adelheid.kuhlmey@charite.de Managing Director Dr. Sabine Damm +49 30 450 529 181 sabine.damm@charite.de Director Institute of General Medicine Dr. Christoph Heintze (acting) Institute of Occupational Medicine Prof. Dr. Adelheid Kuhlmey (acting) Institute of the History of Medicine and Ethics in Medicine Prof. Dr. Volker Hess Institute of Healthcare Research TBA Institute of Health and Nursing Science Prof. Dr. Michael Ewers Institute of Medical Psychology Prof. Dr. Christine Heim Institute of Medical Sociology and Rehabilitation Science Prof. Dr. Adelheid Kuhlmey Institute of Sexology and Sexual Medicine Prof. Dr. Klaus Beier Institute of Social Medicine, Epidemiology and Health Economics Prof. Dr. Stefan Willich Berlin School of Public Health Prof. Dr. Jacqueline Müller-Nordhorn

CC2 CharitéCenter for Basic Sciences Scientific Director Prof. Dr. Britta Eickholt +49 30 450 539 121 britta.eickholt@charite.de Managing Director Thomas Gazlig +49 30 450 528 181 thomas.gazlig@charite.de Director Specialty Network: Anatomy Institute of Integrative Neuroanatomy Prof. Dr. Imre Vida Institute of Vegetative Anatomy Prof. Dr. Sebastian Bachmann Institute of Cell Biology and Neurobiology Prof. Dr. Victor Tarabykin (acting) Specialty Network: Biochemistry and Molecular Biology Institute of Biochemistry Prof. Dr. Britta Eickholt Institute of Molecular Biology and Bioinformatics Prof. Dr. Britta Eickholt (acting) Institute of Biochemistry and Molecular Biology Prof. Dr. Britta Eickholt Institute of Medical Physics and Biophysics Prof. Dr. Christian Spahn Specialty Network: Physiology Institute of Physiology Prof. Dr. Axel R. Pries Institute of Neurophysiology Prof. Dr. Jörg Geiger Institute of Vegetative Physiology Prof. Dr. Pontus B. Persson

CC3 CharitéCenter for Dental, Oral and Maxillary Medicine Scientific Director Prof. Dr. Paul-Georg Jost-Brinkmann +49 30 450 562 522 paul-g.jost-brinkmann@charite.de Managing Director Manfred Datta +49 30 450 562 001 manfred.datta@charite.de Director Institute for Dental, Oral and Maxilary Medicine Prof. Dr. Paul-Georg Jost-Brinkmann

CC4 CharitéCenter for Therapy and Research Scientific Director Prof. Dr. Josef Köhrle +49 30 450 524 021 josef.koehrle@charite.de Managing Director Thomas Gazlig +49 30 450 528 181 thomas.gazlig@charite.de Director Specialty Network: Pharmacology and Toxicology Institute of Clinical Pharmacology and Toxicology Prof. Dr. Ulrich Kintscher Institute of Pharmacology Prof. Dr. Reinhold Kreutz Specialty Network: Biometry, Epidemiology and Medical Computer Science Institute of Medical Biometrics and Clinical Epidemiology Prof. Dr. Josef Köhrle (acting) Institute of Medical Informatics Prof. Dr. Thomas Tolxdorff Institute of Theoretical Biology Prof. Dr. Hans-Peter Herzel Institute of Experimental Endocrinology Prof. Dr. Josef Köhrle Associated: Gender in Medicine (GIM) Prof. Dr. Vera Regitz-Zagrosek

CC5 CharitéCenter for Diagnostic Laboratory and Preventive Medicine Medical Director Prof. Dr. Rudolf Tauber +49 30 8445 2555 rudolf.tauber@charite.de Managing Director Sina Wesoly +49 30 450 569 392 sina.wesoly@charite.de Managing MTA Sigrid Kersten +49 30 450 525 189 sigrid.kersten@charite.de Director Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry Prof. Dr. Rudolf Tauber Institute of Microbiology and Hygiene Prof. Dr. Ulf Göbel Institute of Virology | CBF Prof. Dr. Regine Heilbronn Institute of Virology | CCM Prof. Dr. Detlev Krüger Institute of Legal Medicine and Forensic Sciences Prof. Dr. Michael Tsokos Institute of Forensic Psychiatry Prof. Dr. Hans-Ludwig Kröber Institute of Pathology Prof. Dr. Manfred Dietel Institute of Hygiene and Environmental Medicine Prof. Dr. Petra Gastmeier

CC6 CharitéCenter for Diagnostic and Interventional Radiology and Nuclear Medicine Medical Director Prof. Dr. Bernd Hamm +49 30 450 527 082 bernd.hamm@charite.de Managing Director Arne Weber +49 30 450 527 091 arne.weber@charite.de Managing MTRA Susanne Ortmann +49 30 450 557 071 susanne.ortmann@charite.de Director Institute of Radiology (including Pediatric Radiology and Neuroradiology) Prof. Dr. Bernd Hamm Department of Nuclear Medicine Prof. Dr. Winfried Brenner Institute of Neuroradiology Prof. Dr. Bernd Hamm (acting)

21

CC7 CharitéCenter for Anesthesiology and Intensive Care Medicine Medical Director Prof. Dr. Claudia Spies +49 30 450 531 012 claudia.spies@charite.de Managing Director Dr. Matthes Seeling +49 30 450 651 121 matthes.seeling@charite.de Nursing Director Timo Bechtel +49 30 450 577 048 timo.bechtel@charite.de Director Department of Anesthesiology and Operative Intensive Care Medicine | CCM | CVK Prof. Dr. Claudia Spies Department of Anesthesiology and Operative Intensive Care Medicine | CBF Prof. Dr. Christoph Stein

CC8 CharitéCenter for Surgery Medical Director Prof. Dr. Kurt Miller +49 30 8445 2575 kurt.miller@charite.de Managing Director Axel Köhler +49 30 450 522 001 axel.koehler@charite.de Nursing Director Annett Leifert +49 30 450 552 524 annett.leifert@charite.de Director Department of General, Visceral, Vascular and Thoracic Surgery | CCM Dr. Oliver Haase (acting) Department of General, Visceral and Transplantation Surgery | CVK Prof. Dr. Johann Pratschke Department of General, Visceral and Vascular Surgery | CBF Prof. Dr. Martin E. Kreis Department of Urology Prof. Dr. Kurt Miller

CC9 CharitéCenter for Orthopedics and Traumatology Medical Director Prof. Dr. Norbert Haas +49 30 450 552 012 norbert.haas@charite.de Managing Director Dipl.-Kfm. Gerald Linczak +49 30 450 552 728 gerald.linczak@charite.de Nursing Director Stefanie Bieberstein +49 30 450 577 051 stefanie.bieberstein@charite.de Director Department of Traumatology and Reconstructive Surgery Prof. Dr. Norbert Haas inculding Department of Orthopedic Surgery | CVK | CCM Julius Wolff Institut of Biomechanics and Musculoskeletal Regeneration Prof. Dr.-Ing. Georg Duda Department of Traumatology and Reconstructive Surgery | CBF Prof. Dr. Wolfgang Ertel Department of Oral and Maxillofacial Surgery Prof. Dr. Dr. Bodo Hoffmeister

CC10 Charité Comprehensive Cancer Center Medical Director Prof. Dr. Ulrich Keilholz (acting) +49 30 450 513 501 ulrich.keilholz@charite.de Managing Director Dr. Regina Jünger +49 30 450 540 011 regina.juenger@charite.de Director Charité Comprehensive Cancer Center Prof. Dr. Ulrich Keilholz (acting)

CC11 CharitéCenter for Cardiovascular Diseases Medical Director Prof. Dr. Gert Baumann +49 30 450 513 072 gert.baumann@charite.de Managing Director Dipl.-Kfm. Gerald Linczak +49 30 450 552 728 gerald.linczak@charite.de Nursing Director Stefanie Bieberstein +49 30 450 577 051 stefanie.bieberstein@charite.de Director Department of Cardiology | CBF Prof. Dr. Ulf Landmesser Department of Cardiovascular Surgery Prof. Dr. Wolfgang Konertz Medical Department, Division of Cardiology and Angiology | CCM Prof. Dr. Gert Baumann Medical Department, Division of Cardiology | CVK Prof. Dr. Burkert Pieske

CC12 CharitéCenter for Internal Medicine and Dermatology Medical Director Prof. Dr. Gerd-Rüdiger Burmester +49 30 450 513 061 gerd.burmester@charite.de Managing Director Fred Vock +49 30 450 513 201 fred.vock@charite.de Nursing Director Barbara Jung +49 30 450 677 026 barbara.jung@charite.de Director Medical Department, Division of Rheumatology and Clinical Immunology | CCM Prof. Dr. Gerd-Rüdiger Burmester (including Physical Medicine) | CBF | CCM Medical Department, Division of Infectiology and Pneumonology | CCM / | CVK Prof. Dr. Norbert Suttorp (including Outpatient Pneumology) Medical Outpatient | CCM Prof. Dr. Jürgen Scholze Department of Dermatology, Venerology and Allergology Prof. Dr. Torsten Zuberbier (acting) Institute of Medical Immunology Prof. Dr. Hans-Dieter Volk Medical Department, Division of Psychosomatic Medicine Prof. Dr. Matthias Rose

CC13 CharitéCenter for Internal Medicine with Gastroenterology and Nephrology Medical Director Prof. Dr. Bertram Wiedenmann +49 30 450 553 022 bertram.wiedenmann@charite.de Managing Director Volker Schnittger +49 30 450 513 181 volker.schnittger@charite.de Nursing Director Dagmar Hildebrand +49 30 450 577 368 dagmar.hildebrand@charite.de Director Specialty Network: Nephrology Medical Department, Division of Nephrology and Internal Intensive Care Medicine | CVK Prof. Dr. Achim Jörres (acting) Medical Department, Division of Nephrology | CCM Prof. Dr. Klemens Budde Department of Nephrology | CBF Prof. Dr. Walter Zidek

22

Specialty Network: Gastroenterology, Endocrinology and Metabolic Diseases Medical Department, Division of Hepatology and Gastroenterology | CVK | CBF Prof. Dr. Bertram Wiedenmann (including Metabolic Diseases) Department of Gastroenterology, Infectiology and Rheumatology | CBF Prof. Dr. Britta Siegmund (acting) (including Nutrition Medicine) Department of Endocrinology and Metabolic Diseases Prof. Dr. Joachim Spranger (including Division of Lipid Metabolism) Institute of Clinical Physiology TBA Emergency Department | CBF Prof. Dr. Rajan Somasundaram Emergency Departments | CVK | CCM Prof. Dr. Martin Möckel

CC14 CharitéCenter for Tumor Medicine Medical Director Prof. Dr. Bernd Dörken +49 30 450 553 111 bernd.doerken@charite.de Managing Director Dr. Felix Mehrhof +49 30 450 513 274 felix.mehrhof@charite.de Nursing Director Judith Heepe +49 30 450 577 098 judith.heepe@charite.de Director Medical Department, Division of Oncology and Hematology | CCM Prof. Dr. Hanno Riess Medical Department, Division of Hematology, Oncology | CBF Prof. Dr. Antonio Pezzutto Medical Department, Division of Hematology, Oncology and Tumor Immunology | CVK Prof. Dr. Bernd Dörken Department of Radiation Oncology and Radiotherapy | CCM | CVK Prof. Dr. Volker Budach Department of Radiation Oncology and Radiotherapy | CBF Prof. Dr. Volker Budach Institute of Immunology Prof. Dr. Thomas Blankenstein Institute of Transfusion Medicine Prof. Dr. Abdulgabar Salama

CC15 CharitéCenter for Neurology, Neurosurgery and Psychiatry Medical Director Prof. Dr. Matthias Endres +49 30 450 560 101 matthias.endres@charite.de Managing Director PD Dr. Uwe Reuter +49 30 450 560 274 uwe.reuter@charite.de Nursing Director Sinah Krueger +49 30 450 677 035 sinah.krueger@charite.de Director Department of Neurology with Experimental Neurology Prof. Dr. Matthias Endres Department of Psychiatry and Psychotherapy | CCM Prof. Dr. Andreas Heinz Department of Psychiatry and Psychotherapy | CBF Prof. Dr. Isabella Heuser-Collier Department of Neurosurgery with Pediatric Neurosurgery Prof. Dr. Peter Vajkoczy Institute of Neuropathology Prof. Dr. Frank Heppner

CC16 CharitéCenter for Audiology / Phoniatrics, Ophthalmology and Otolaryngology Medical Director Prof. Dr. Manfred Gross +49 30 450 555 401 manfred.gross@charite.de Managing Director Christoph Wigger +49 30 450 555 161 christoph.wigger@charite.de Nursing Director Diane Jetschmann +49 30 450 577 118 diane.jetschmann@charite.de Director Department of Ophthalmology Prof. Dr. Antonia Joussen Department of Otolaryngology Site Management CVK | CCM Prof. Dr. Heidi Olze Site Management CBF PD Dr. Minoo Lenarz Department of Audiology and Phoniatrics Prof. Dr. Manfred Gross

CC17 CharitéCenter for Gynecology, Perinatal, Pediatric and Adolescent Medicine with Perinatal Center and Human Genetics Medical Director Prof. Dr. Ulrike Lehmkuhl +49 30 450 566 202 ulrike.lehmkuhl@charite.de Managing Med. Director PD Dr. Uwe Reuter +49 30 450 566 321 uwe.reuter@charite.de Managing Director Juliane Kaufmann +49 30 450 566 341 juliane.kaufmann@charite.de Nursing Director Judith Heepe +49 30 450 577 098 judith.heepe@charite.de Sinah Krüger +49 30 450 677 035 sinah.krueger@charite.de Director Specialty Network: Perinatal Medicine Department of Obstetrics Prof. Dr. Wolfgang Henrich Department of Neonatology Prof. Dr. Christoph Bührer Further Facilities Department of Gynecology with Center for Oncological Surgery Prof. Dr. Jalid Sehouli Department of Gynecology with Breast Center of the Charité | CCM Prof. Dr. Jens-Uwe Blohmer Department of Gynecology | CV | CBF Prof. Dr. Jalid Sehouli (CBF acting) Specialty Network: Pediatrics and Youth Medicine Department of Pediatrics, Endocrinology and Diabetology Prof. Dr. Annette Grüters-Kieslich Department of Pediatrics Endocrinology, Gastroenterology and Metabolic Medicine Prof. Dr. Angelika Eggert (acting) Department of Pediatrics, Division of Cardiology Prof. Dr. Felix Berger Department of Pediatrics, Division of Pneumonology and Immunology Prof. Dr. Bodo Niggemann (acting) and Intensive Medicine including Emergency Department Department of Pediatrics, Division of Oncology and Hematology Prof. Dr. Angelika Eggert Department of Pediatrics, Division of Nephrology Prof. Dr. Uwe Querfeld Department of Pediatrics, Division of Neurology Prof. Dr. Christoph Hübner Department of Pediatric Surgery Prof. Dr. Karin Rothe Center for Social Pediatrics Dr. Theodor Michael Department of Child and Adolescent Psychiatry, Psychosomatic Medicine Prof. Dr. Ulrike Lehmkuhl and Psychotherapy Institute of Experimental Pediatric Endocrinology Prof. Dr. Heiko Krude Further Facilities Institute of Medical Genetics Prof. Dr. Bernhard Herrmann Institute of Medical Genetics and Human Genetics Prof. Dr. Stefan Mundlos

Last update: March 2015

23

Ausgewählte Publikationen 2014*Selected Publications 2014*

CC1 für Human- und Gesundheitswissenschaften

Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD. Maternal estriol (E3) concentrations in early gestation predict infant telomere length. Journal of Clinical Endocrinology & Metabolims. 2014 Oct 22:jc20142744.

Grabenhenrich L, Gough H, Reich A, Eckers N, Zepp F, Nitsche O, Forster J, Schuster A, Schramm D, Bauer CP, Hoffmann U, Beschorner J, Wag- ner P, Bergmann RL, Bergmann KE, Matricardi PM, Wahn U, Laus S, Keil T. Early life determinants of asthma from birth to age 20: a Ger-man birth cohort study. J Allergy Clin Immunol 2014;133(4):979-88.

Hess V, Mendelsohn A. Sauvages‘ paperwork: how disease classifi- cation arose from scholarly note-taking. Early Sci Med. 2014;19 (5):471-503.

Muckelbauer R, Barbosa CL, Mittag T, Burkhardt K, Mikelaishvili N, Müller-Nordhorn J. Association between water consumption und body weight outcomes in children and adolescents: a systematic review. Obesity. 2014; 22(12):2462-75.

Schauber SK, Schalk L. Matters of detail - does basic science content support future learning? Medical Education. 2014; 48 (7): 650-652.

CC2 für Grundlagenmedizin

Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJ, Mielke T, Ismer J, Hildebrand PW, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CM. Regulation of the mammalian elongation cycle by sub- unit rolling: a eukaryotic-specific ribosome rearrangement. Cell. 2014 Jul 3;158(1):121-31.

Frielingsdorf S, Fritsch J, Schmidt A, Hammer M, Löwenstein J, Siebert E, Pelmenschikov V, Jaenicke T, Kalms J, Rippers Y, Lendzian F, Zebger I, Teutloff C, Kaupp M, Bittl R, Hildebrandt P, Friedrich B, Lenz O, Scheerer P. Reversible [4Fe-3S] cluster morphing in an O(2)-tolerant [NiFe] hydrogenase. Nat Chem Biol. 2014 May;10(5):378-85.

Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M, Schrötter S, Eickholt BJ, van den Heuvel L, Casamina C, Stoltenburg-Didinger G, Ropers HH, Wienker TF, Hübner C, Kaindl AM. Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness. Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35.

Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo AL, Ackerman SL, Richards LJ, Tarabykin V. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. Nat Commun. 2014 Apr 17;5:3708.

Yamamoto H, Unbehaun A, Loerke J, Behrmann E, Collier M, Bürger J, Mielke T, Spahn CM. Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA. Nat Struct Mol Biol. 2014 Aug;21(8):721-7.

CC3 für Zahn-, Mund- und Kieferheilkunde

Radlanski RJ. An equilibrating splint combined with active orthodontic screw segments for the initial treatment of patients with a posterior forced bite. J of Craniomandibular Function. 2014; (6) 117-129.

Rafayelyan S, Meyer P, Radlanski RJ, Minden K, Jost-Brinkmann PG, Präger TM. Effect of methotrexate upon antigen-induced arthritis of the rabbit temporomandibular joint. J Oral Pathol Med. 2014 Sep 22.

Schwendicke F, Dörfer CE, Schlattmann P, Page LF, Thomson WM, Paris S. Socioeconomic inequality and caries: a systematic review and meta-analysis. J Dent Res. 2015 Jan;94(1):10-8.

Strietzel FP, Neumann K, Hertel M. Impact of platform switching on marginal peri-implant bone level changes. A systematic review and meta-analysis. Clin Oral Implants Res 2014. Epub 2014 Jan 20.

Walter MH, Marré B, Vach K, Strub J, Mundt T, Stark H, Pospiech P, Wöstmann B, Heydecke G, Kern M, Hartmann S, Luthardt R, Huppertz J, Wolfart S, Hannak W. Management of shortened dental arches and periodontal health: 5-year results of a randomised trial. J Oral Rehabil. 2014 Jul;41(7):515-22.

CC4 für Therapieforschung

Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium. Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA. 2014 Apr 23-30;311(16):1622-31.

Douros A, Schlemm L, Bolbrinker J, Ebinger M, Kreutz R. Insufficient anticoagulation with dabigatran in a patient with short bowel syndrome. Thromb Haemost. 2014 Aug;112(2):419-20.

Lauer D, Slavic S, Sommerfeld M, Thöne-Reineke C, Sharkovska Y, Hall-berg A, Dahlöf B, Kintscher U, Unger T, Steckelings UM, Kaschina E. Angiotensin type 2 receptor stimulation ameliorates left ventri-cular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor ß1 in the rat heart. Hypertension. 2014 Mar;63(3):e60-7.

Lück S, Thurley K, Thaben PF, Westermark PO. Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Rep. 2014 Oct 23;9(2):741-51.

Schweizer U, Schlicker C, Braun D, Köhrle J, Steegborn C. Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10526-31.

CC5 für diagnostische und präventive Labormedizin

Dernedde J, Weise C, Müller EC, Hagiwara A, Bachmann S, Suzuki M, Reutter W, Tauber R, Scherer H. Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear. PLoS ONE. 2014;9(11):e111917.

Hüser D, Gogol-Döring A, Chen W, Heilbronn R. Adeno-associated virus type 2 wild-type and vector-mediated genomic integration profiles of human diploid fibroblasts analyzed by third-generation PacBio DNA sequencing. J Virol. 2014 Oct;88(19):11253-63.

Loibl S, von Minckwitz G, Schneeweiss A, Paepke S, Lehmann A, Rezai M, ZahmDM, Sinn P, Khandan F, Eidtmann H, Dohnal K, Heinrichs C, Huober J, Pfitzner B, Fasching PA, Andre F, Lindner JL, Sotiriou C, Dykgers A, Guo S, Gade S, Nekljudova V, Loi S, Untch M, Denkert C. PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer. J Clin Oncol. 2014 Oct 10;32(29):3212-20.

Raftery MJ, Lalwani P, Krautkrämer E, Peters T, Scharffetter-Kochanek K, Krüger R, Hofmann J, Seeger K, Krüger DH, Schönrich G. Beta-2 integrin mediates hantavirus-induced release of neutrophil extracellular traps. J. Exp. Med. 2014 Jun 30; 211(7):1485-97.

Ruhnke M, Arnold R, Gastmeier P. Infection control issues in patients with haematological malignancies in the era of multidrug-resistant bacteria. Lancet Oncol 2014; 15:e606-19.

CC6 für diagnostische und interventionelle Radiologie und Nuklearmedizin

Braun J, Guo J, Lützkendorf R, Stadler J, Papazoglou S, Hirsch S, Sack I & Bernarding J. High-resolution mechanical imaging of the human brain by three-dimensional multifrequency magnetic resonance elastography at 7T. Neuroimage. 2014;90:308-14.

Elgeti T, Knebel F, Hättasch R, Hamm B, Braun J & Sack I. Shear-wave amplitudes measured with cardiac MR elastography for diagnosis of diastolic dysfunction. Radiology. 2014;271(3):681-7. 6,214.

Haeckel A, Appler F, Figge L, Kratz H, Lukas M, Michel R, Schnorr J, Zille M, Hamm B & Schellenberger E. XTEN-annexin A5: XTEN allows complete expression of long-circulating protein-based imaging probes as recombinant alternative to PEGylation. J Nucl Med. 2014;55(3):508-14.

Schilling R, Jastram B, Wings O, Schwarz-Wings D & Issever AS. Revi-ving the dinosaur: virtual reconstruction and three-dimensional printing of a dinosaur vertebra. Radiology. 2014;270(3):864-71.

Walther S, Schueler S, Tackmann R, Schuetz G.M, Schlattmann P & Dewey M. Compliance with STARD checklist among studies of coronary CT angiography: systematic review. Radiology. 2014;271(1):74-86.

CC7 für Anästhesiologie und Intensivmedizin

Feldheiser A, Hunsicker O, Krebbel H, Weimann K, Kaufner L, Wernecke KD & Spies C. Oesophageal Doppler and calibrated pulse contour analysis are not interchangeable within a goal-directed haemo-dynamic algorithm in major gynaecological surgery? Brit J Anaesth. 2014;1:4-5.

Kumpf O, Bloos F, Bause H, Brinkmann A, Deja M, Marx G, Kaltwasser A, Dubb R, Muhl E, Greim CA, Weiler N, Chop I, Jonitz G, Schaefer H, Felsenstein M, Liebeskind U, Leffmann C, Jungbluth A, Waydhas C,

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Pronovost P, Spies C, Braun JP & NeQuI-Group (Netzwerk Qualität in der Intensivmedizin). Voluntary peer review as innovative tool for quality improvement in the intensive care unit - a retrospective descriptive cohort study in German intensive care units. Ger Med Sci. 2014;12:Doc17.

Luetz A, Balzer F, Radtke FM, Jones C, Citerio G, Walder B, Weiss B, Wernecke KD, Spies C. Delirium, sedation and analgesia in the intensive care unit: a multinational, two-part survey among intensivists. PLoS One. 2014 Nov 14;9(11):e110935.

Nachtigall I, Tafelski S, Günzel K, Uhrig A, Powollik R, Tamarkin A, Wernecke KD & Spies C. Standard operating procedures for antibiotic therapy and the occurrence of acute kidney injury: a prospective, clinical, non-interventional, observational study. Crit Care. 2014;18(3):R120.

Schmidt M, Neuner B, Kindler A, Scholtz K, Eckardt R, Neuhaus P & Spies C. Prediction of long-term mortality by preoperative health-related quality-of-life in elderly onco-surgical patients. PLoS ONE. 2014;9(1):e85456.

CC8 für Chirurgische Medizin

Busch J, Seidel C, Goranova I, Erber B, Peters R, Friedersdorff F, Magheli A, Miller K, Grünwald V, Weikert S. Categories of response to first line vascular endothelial growth factor receptor targeted therapy and overall survival in patients with metastatic renal cell carcinoma. Eur J Cancer. 2014 Feb;50(3):563-9.

Friedersdorff F, Manus P, Miller K, Lein M, Jung K, Stephan C. Serum testosterone improves the accuracy of Prostate Health Index for the detection of prostate cancer. Clin Biochem. 2014 Jul;47 (10-11):916-20.

Gerlach UA, Atanasov G, Wallenta L, Polenz D, Reutzel-Selke A, Kloepfel M, Jurisch A, Marksteiner M, Loddenkemper C, Neuhaus P, Sawitzki B, Pascher A. Short-term TNF-alpha inhibition reduces short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation. Transplantation. 2014 Apr 15;97(7):732-739.

Struecker B, Raschzok N, Sauer IM. Liver support strategies: cutting-edge technologies. Nat Rev Gastroenterol Hepatol. 2014 Mar;11(3):166-176.

Zurbuchen U, Schwenk W, Junghans T, Modersohn D, Haase O. Vagus-preserving technique during minimally invasive esophagectomy: the effects on cardiac parameters in a swine model. Surgery. 2014 Jul;156(1):46-56.

CC9 für Orthopädie und Unfallchirurgie

Klatte-Schulz F, Gerhardt C, Scheibel M, Wildemann B, Pauly S. Relationship between muscle fatty infiltration and the biologi- cal characteristics and stimulation potential of tenocytes from rotator cuff tears. J Orthop Res. 2014 Jan;32(1):129-37.

Kleber C, Giesecke MT, Lindner T, Haas NP, Buschmann CT. Requirement for a structured algorithm in cardiac arrest following major trauma: epidemiology, management errors, and preventability of traumatic deaths in Berlin. Resuscitation. 2014 Mar;85(3):405-1.

Mihailescu R, Furustrand Tafin U, Corvec S, Oliva A, Betrisey B, Borens O, Trampuz A. High activity of fosfomycin and rifam-pin against methicillin-resistant Staphylococcus aureus (MRSA) biofilm in vitro and in experimental foreign-body infection model. Antimicrob Agents Chemother 2014; 58: 2547-53.

Pfitzner T, Abdel MP, von Roth P, Perka C, Hommel H. Small improve-ments in mechanical axis alignment achieved with MRI versus CT-based patient-specific instruments in TKA: a randomized clinical trial. Clin Orthop Relat Res. 2014 Oct;472(10):2913-22.

von Roth P, Abdel MP, Wauer F, Winkler T, Wassilew G, Diederichs G, Perka C. Significant muscle damage after multiple revision total hip replacements through the direct lateral approach. Bone Joint J. 2014 Dec;96-B(12):1618-22.

CC10 Charité Comprehensive Cancer Center

Berger A, Quast SA, Plötz M, Kuhn NF, Trefzer U, Eberle J. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-40.

Denkert C, von Minckwitz G, Brase JC, Sinn BV, Gade S, Kronen-wett R, Pfitzner BM, Salat C, Loi S, Schmitt WD, Schem C, Fisch K, Darb-Esfahani S, Mehta K, Sotiriou C, Wienert S, Klare P, André F, Klauschen F, Blohmer JU, Krappmann K, Schmidt M, Tesch H,

Kümmel S, Sinn P, Jackisch C, Dietel M, Reimer T, Untch M, Loibl S. Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy With or Without Carboplatin in Human Epidermal Growth Factor Receptor 2-Positive and Triple-Negative Primary Breast Cancers. J Clin Oncol. 2014 Dec 22.

Irving J, Matheson E, Minto L, Blair H, Case M, Halsey C, Swidenbank I, Ponthan F, Kirschner-Schwabe R, Groeneveld-Krentz S, Hof J, Allan J, Harrison C, Vormoor J, von Stackelberg A, Eckert C. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014 Nov 27;124(23):3420-30.

Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD. Mutational spectrum of adult T-ALL. Oncotarget. 2014 Jul 15.

Relógio A, Thomas P, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C. Ras-mediated deregulation of the circadian clock in cancer. PLoS Genet. 2014 May 29;10(5):e1004338.

CC11 für Herz-, Kreislauf- und Gefäßmedizin

Baldenhofer G, Zhang K, Spethmann S, Laule M, Eilers B, Leonhardt F, Sanad W, Dreger H, Sander M, Grubitzsch H, Baumann G, Stangl K, Stangl V, Knebel F. Galectin-3 predicts short- and long-term outcome in patients undergoing transcatheter aortic valve implantation (TAVI). Int J Cardiol. 2014 Dec 20;177(3):912-7.

Christ T, Grubitzsch H, Claus B, Konertz W. Long-term follow-up after aortic valve replacement with Edwards Prima Plus stentless bioprostheses in patients younger than 60 years of age. J Thorac Cardiovasc Surg. 2014 Jan;147(1):264-9.

Hewing B, Parathath S, Barrett T, Chung WK, Astudillo YM, Hamada T, Ramkhelawon B, Tallant TC, Yusufishaq MS, Didonato JA, Huang Y, Buffa J, Berisha SZ, Smith JD, Hazen SL, Fisher EA. Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):779-89.

CC12 für Innere Medizin und Dermatologie

Burmester GR, Kivitz AJ, Kupper H, Arulmani U, Florentinus S, Goss SL, Rathmann SS, Fleischmann RM. Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the ran-domised CONCERTO trial. Ann Rheum Dis. 2014 Feb 18.

Burmester GR, Feist E, Dörner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol. 2014 Feb;10(2):77-88.

Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci Transl Med. 2014 Jun 18;6(241):241ra80.

Rösel AL, Scheibenbogen C, Schliesser U, Sollwedel A, Hoffmeister B, Hanitsch L, von Bernuth H, Krüger R, Warnatz K, Volk HD, Thomas S. Classification of common variable immunodeficiencies using flow cytometry and a memory B-cell functionality assay. J Allergy Clin Immunol. 2015 Jan;135(1):198-208.e5.

Tabeling C, Scheer H, Schönrock S, Runge F, Gutbier B, Lienau J, Hamel- mann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzen- rath M. Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyper-responsiveness. Am J Respir Cell Mol Biol. 2014, 50:903-11.

CC13 für Innere Medizin mit Gastroenterologie und Nephrologie

Bücker R, Schulz E, Günzel D, Bojarski C, Lee IF, John LJ, Wiegand S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm M, Siegmund B, Troeger H, Schulzke JD. Alspha-Haemolysin of Escherichia coli in IBD: a potentiator of inflammatory activity in the colon. Gut. 2014 Dec;63(12):1893-1901.

Eickmeier I, Seidel D, Grün JR, Derkow K, Lehnardt S, Kühl AA, Hamann A & Schott E. Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation. J Hepatol. 2014;60(6):1143-50.

Göhrig A, Detjen KM, Hilfenhaus G, Körner JL, Welzel M, Arsenic R, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C. Axon guidance factor SLIT2 inhibits neural invasion and metastasis in pancreatic cancer. Cancer Res. 2014 Mar 1;74(5):1529-40.

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Sandek A, Swidsinski A, Schroedl W, Watson A, Valentova M., Herrmann R, Scherbakov N, Cramer L, Rauchhaus M, Grosse-Herrenthey A, Krueger M, von Haehling S, Doehner W, Anker SD & Bauditz J. Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia. J Am Coll Cardiol. 2014; 64(11):1092-102.

Seidel D, Eickmeier I, Kühl AA, Hamann A, Loddenkemper C & Schott E. CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice. Hepatology. 2014;59(2):601-11.

CC14 für Tumormedizin

Türkmen S, Binder A, Gerlach A, Niehage S, Theodora Melissari M, Inandiklioglu N, Dörken B, Burmeister T. High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS. Genes Chromosomes Cancer. 2014 Aug;53(8):650-6.

Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B, Bonifer C and Mathas S. Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. P. Natl. Acad. Sci. USA. 2014; 111(42):E4513-22.

Listopad J, Kammertoens T, Anders K, Silkenstedt B, Willimsky G, Schmidt K, Kühl A, Loddenkemper C and Blankenstein Th. Fas expression by tumor stroma is required for cancer eradication. Proc. Natl. Acad. Sci. USA 2013; 110: 2276-2281.

Oettle H, Riess H, Stieler JM, Heil G, Schwaner I, Seraphin J, Görner M, Mölle M, Greten TF, Lakner V, Bischoff S, Sinn M, Dörken B. and Pelzer U. Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. J. Clin. Oncol. 2014; 32(23):2423-9.

Willimsky G, Schmidt K, Loddenkemper C, Gellermann J and Blanken-stein Th. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J. Clin. Invest. 2013; 123: 1032-1043.

CC15 für Neurologie, Neurochirurgie und Psychiatrie

Erk S, Meyer-Lindenberg A, Schmierer P, Mohnke S, Grimm O, Garbusow M, Haddad L, Poehland L, Mühleisen TW, Wittt SH, Tost H, Kirsch P, Romanczuk-Seiferth N, Schott B, Cichon S, Nöthen MM, Rietschel M, Heinz A, Walter H (2014) Hippocampal and Frontolimbic Function as Intermediate Phenotype for Psychosis: Evidence from Healthy Relatives and a Common Risk Variant in CACNA1C. Biological Psychiatry. 2014; (76(6): 466-475.

Fuge P, Aust S, Fan Y, Weigand A, Gärtner M, Feeser M, Bajbouj M, Grimm S. Interaction of early life stress and corticotropin-releasing hormone receptor gene: effects on working memory. Biol Psychiatry. 2014 Dec 1;76(11):888-94.

Neumann WJ, Huebl J, Brücke C, Gabriëls L, Bajbouj M, Merkl A, Schnei-der GH, Nuttin B, Brown P and Kühn AA. Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder. MolPsych 2014 Feb 11.

Whelan R, Watts R, Orr CA, Althoff RR, Artiges E, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Carvalho FM, Conrod PJ, Flor H, Fauth-Bühler M, Frouin V, Gallinat J, Gan G, Gowland P, Heinz A, Ittermann B, Lawrence C, Mann K, Martinot JL, Nees F, Ortiz N, Paillère-Martinot ML, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Ströhle A, Schumann G, Garavan H; IMAGEN Consortium. Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature. 2014 Aug 14;512(7513):185-9.

Wingenfeld K, Kuehl LK, Janke K, Hinkelmann K, Dziobek I, Fleischer J, Otte C, Roepke S. Enhanced emotional empathy after mineralocorticoid receptor stimulation in women with borderline personality disorder and healthy women. Neuropsychopharmacology. 2014 Jul;39(8):1799-804.

CC16 für Audiologie/Phoniatrie, Augen- und HNO-Heilkunde

Göktas Ö, Solmaz M, Göktas G, Olze H. Long-term results in obstruc- tive sleep apnea syndrome (OSAS) after laser-assisted uvulo-palatoplasty (LAUP). PLoS One. 2014 Jun 30;9(6):e100211.

Haseleu J, Omerbašic D, Frenzel H, Gross M, Lewin GR. Water-Induced Finger Wrinkles Do Not Affect Touch Acuity or Dexterity in Handling Wet Objects. PLOS One; January 08, 2014; DOI: 10.1371/journal.pone. 0084949 2014; Volume:9 Issue:(1).

Klinghammer K, Raguse JD, Plath T, Albers AE, Joehrens K, Zakarneh A, Brzezicha B, Wulf-Goldenberg A, Keilholz U, Hoffmann J & Fichtner I. A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option. Int J Cancer 2014;1(1):1.

Lin J, Albers AE, Qin J & Kaufmann AM. Prognostic significance of overexpressed p16INK4a in patients with cervical cancer: a meta-analysis. PLoS ONE 2014;9(9):e106384.

CC17 für Frauen-, Kinder- und Jugendmedizin mit Perinatalzentrum und Humangenetik

Blumchen K, Beder A, Beschorner J, Ahrens F, Gruebl A, Hamelmann E, Hansen G, Heinzmann A, Nemat K, Niggemann B, Wahn U, Beyer K. Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy. J Allergy Clin Immunol. 2014 Aug;134(2):390-8.

Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, König L, Vetter B, Lenac-Rovis T, Jonjic S, Neitzel H, Hagemeier C, Wie-busch L. PUL21a-Cyclin A2interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry. PLoS Pathog. 2014 Nov 13;10(10): e1004514.

Kappel V, Lorenz RC, Streifling M, Renneberg B, Lehmkuhl U, Ströhle A, Salbach-Andrae H, Beck A. Effect of brain structure and function on reward anticipation in children and adults with attention deficit hyperactivity disorder combined subtype. Soc Cogn Affect Neurosci. 2014 Oct 22.

Schwarz JM, Cooper DN, Schuelke M, Seelow D. MutationTaster2: mutation prediction for the deep-sequencing age. Nat Methods. 2014;11(4):361-2.

Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, Graul-Neumann L, Doelken S, Ehmke N, Spielmann M, Oien NC, Schweiger MR, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R, Ardeshirdavani A, Moreau Y, Lewis SE, Haendel M, Smedley D, Horn D, Mundlos S, Robinson PN. Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Sci Transl Med. 2014 Sep 3;6(252):252ra123.

NWFZ Neurowissenschaftliches Forschungszentrum

Herman MA, Ackermann F, Trimbuch T, Rosenmund C. Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture. J Neurosci. 2014 Aug 27;34(35):11781-91.

Schmitz D, Breustedt J, Gundlfinger A. Retrograde signaling causes excitement. Neuron. 2014 Feb 19;81(4):717-9.

Watanabe S, Trimbuch T, Camacho-Pérez M, Rost BR, Brokowski B, Söhl-Kielczynski B, Felies A, Davis MW, Rosenmund C, Jorgensen EM. Clathrin regenerates synaptic vesicles from endosomes. Nature. 2014 Nov 13;515(7526):228-33.

MKFZ Molekulares Krebsforschungszentrum

Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S, Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature. 2013 Sep 19;501(7467):421-5.

Heinig K, Gätjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K, Niesner RA, Cseresnyes Z, Hauser AE, Lenz P, Hehlgans T, Brink R, Westermann J, Dörken B, Lipp M, Lenz G, Rehm A, Höpken UE. Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation. Cancer Discov. 2014 Dec;4(12):1448-65.

Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E,Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F. Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. Nat Med. 2014 Jan;20(1):87-92.

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Rehm A, Gätjen M, Gerlach K, Scholz F, Mensen A, Gloger M, Heinig K, Lamprecht B, Mathas S, Bégay V, Leutz A, Lipp M, Dörken B, Höpken UE. Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ. Nat Commun. 2014 Sep 30;5:5057.

Ullrich K, Blumenthal-Barby F, Lamprecht B, Köchert K, Lenze D, Hummel M, Mathas S, Dörken B, Janz M. The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells. Leukemia. 2014 Dec 9.

RCIS Research Center ImmunoSciences

Liu FD, Kenngott EE, Schröter MF, Kühl A, Jennrich S, Watzlawick R, Hoff- mann U, Wolff T, Norley S, Scheffold A, Stumhofer JS, Saris CJ, Schwab JM, Hunter CA, Debes GF, Hamann A. Timed action of IL-27 protects from immunopathology while preserving defense in influenza. PLoS Pathog. 2014 May 8;10(5).

Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Blei- enheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A. Ubiquitin-like protein ISG15 in host defense against heart failure in a mouse model of virus-induced cardiomyopathy. Circulation 2014; 130:1589-1600.

Schumann J, Stanko K, Woertge S, Appelt C, Schumann M, Kühl AA, Panov I, Schliesser U, Vogel S, Ahrlich S, Vaeth M, Berberich-Siebelt F, Waisman A, Sawitzki B. The mitochondrial protein TCAIM regulates activation of T cells and thereby promotes tolerance induction of allogeneic transplants. Am J Transplant. 2014 Dec;14(12):2723-35.

Syrbe U, Siegmund B. Bone marrow Th17 TNFα cells induce osteoclast differentiation and link bone destruction to IBD. Gut. 2014 Nov 12.

Weller, K., Groffik, A., Church, M. K., Hawro, T., Krause, K., Metz, M., Martus, P., Casale, T., Staubach, P., and Maurer, M. Development and validation of the urticaria control test – a patient reported outcome instru- ment for assessing urticaria control. J. Allergy Clin. Immunol. 2014. 133; 1365-1372.

CCR Center for Cardiovascular Research

Becker MO, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Schermuly RT, Nickel N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester GR, Dragun D*, Riemekasten G*. Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis. Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17. (*shared senior and corresponding authors)

Buschmann I, Hackbusch D, Gatzke N, Dülsner A, Trappiel M, Dagnell M, Ostman A, Hooft van Huijsduijnen R, Kappert K. Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats. J Mol Med (Berl). 2014 Sep;92(9):983-94.

Freise C, Querfeld U. Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34. Pharmacol Res. 2014 Jul;85:6-14.

Kararigas G, Dworatzek E, Petrov G, Summer H, Schulze TM, Baczko I, Knosalla C, Golz S, Hetzer R, Regitz-Zagrosek V. Sex-dependent regu- lation of fibrosis and inflammation in human left ventricular remo- delling under pressure overload. Eur J Heart Fail. 2014 Nov;16(11):1160-7.

Petrov G, Dworatzek E, Schulze TM, Dandel M, Kararigas G, Mahmoodzadeh S, Knosalla C, Hetzer R, Regitz-Zagrosek V. Maladaptive remodeling is associated with impaired survival in women but not in men after aortic valve replacement. JACC Cardiovasc Imaging. 2014 Nov;7(11):1073-80.

BCRT Berlin-Brandenburg Centrum für Regenerative Therapien

Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider C K. A road-map toward clinical translation of genetically-modified stem cells for treatment of HIV. Trends Mol Med. 2014 Nov;20(11):632-42.

Andreas K, Sittinger M, Ringe J. Toward in situ tissue engineering: chemokine-guided stem cell recruitment. Trends Biotechnol. 2014 Sep;32(9):483-92.

Duda GN, Grainger DW, Frisk ML, Bruckner-Tuderman L, Carr A, Dirnagl U, Einhäupl KM, Gottschalk S, Gruskin E, Huber C, June CH, Mooney DJ, Rietschel ET, Schütte G, Seeger W, Stevens MM, Urban R, Veldman A, Wess G, Volk HD. Changing the mindset in life sciences toward trans-lation: a consensus. Sci Transl Med. 2014 Nov 26;6(264):264cm12.

Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V, Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H, Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM, Nürnberg P, Siebert R, Manzke H, Mundlos S. Homozygous and compound-heterozygous mutations in TGDS cause Catel-Manzke syndrome. Am J Hum Genet. 2014 Dec 4;95(6):763-70.

Ringe J, Sittinger M. Regenerative medicine: Selecting the right biological scaffold for tissue engineering. Nat Rev Rheumatol. 2014 Jul;10(7):388-9.

ECRC Experimental and Clinical Research Center

Grunert M, Dorn C, Schueler M, Dunkel I, Schlesinger J, Mebus S, Alexi-Meskishvili V, Perrot A, Wassilew K, Timmermann B, Hetzer R, Berger F, Sperling SR. Rare and private variations in neural crest, apoptosis and sarcomere genes define the polygenic background of isolated Tetralogy of Fallot. Hum Mol Genet. 2014 Jun 15;23(12):3115-28.

Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izs-vák Z, Spuler S. Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest. 2014 Oct 1;124(10):4257-65.

Mensen A, Jöhrens K, Anagnostopoulos I, Demski S, Oey M, Stroux A, Hemmati P, Westermann J, Blau O, Wittenbecher F, Movassaghi K, Szyska M, Thomas S, Dörken B, Scheibenbogen C, Arnold R, Na IK. Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT. Blood. 2014 Aug 7;124(6):963-72.

Schleifenbaum J, Kassmann M, Szijártó IA, Hercule HC, Tano JY, Weinert S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader M, Jentsch TJ, Gollasch M. Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries. Circ Res. 2014 Jul 7;115(2):263-72.

Simaite D, Kofent J, Gong M, Rüschendorf F, Jia S, Arn P, Bentler K, Ellaway C, Kühnen P, Hoffmann GF, Blau N, Spagnoli FM, Hübner N, Raile K. Recessive mutations in PCBD1 cause a new type of early-onset diabetes. Diabetes. 2014 Oct;63(10):3557-64.

* Die Auswahl der Publikationen zeigt das breite Spektrum bio- medizinischer Forschung an der Charité. Eine vollständige Liste aller wissenschaftlichen Publikationen der Charité kann unter http://www.charite.de/forschung eingesehen werden.

* The selected publications reflect the wide range of biomedical research done at the Charité. For a comprehensive index of all scientific publications at the Charité please go to http://www.charite.de/forschung.