Table S1, SDC. Common deregulated genes between WS and S (L1 vs. L2)
Symbol Entrez Gene Name Group S
(Probesets)
S (Fold-
change)
Group WS (Probesets)
WS (Fold-
change)
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
203504_s_at -1.4 203505_at -1.3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
203196_at -1.4 203196_at -1.5
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
202850_at -1.4 202850_at -1.2
ADCY1 adenylate cyclase 1 (brain) 213245_at -2.0 213245_at -2.1 ADM adrenomedullin 202912_at 2.4 202912_at 2.0 ADORA3 adenosine A3 receptor 206171_at -1.6 206171_at -1.4 ADRB2 adrenoceptor beta 2, surface 206170_at 2.4 206170_at 2.2
AGO1 argonaute RISC catalytic component 1
218287_s_at -1.3 218287_s_at -1.3
ANAPC5 anaphase promoting complex subunit 5
208722_s_at -1.3 211036_x_at -1.3
APOLD1 apolipoprotein L domain containing 1
221031_s_at 2.8 221031_s_at 3.2
AREG amphiregulin 205239_at 4.7 205239_at 4.7
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
218098_at -1.7 218098_at -1.4
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
201878_at 1.4 201878_at 1.3
ARL2 ADP-ribosylation factor-like 2 202564_x_at -1.2 202564_x_at -1.3
ARL4C ADP-ribosylation factor-like 4C
202207_at 1.5 202207_at 1.7
ARMC8 armadillo repeat containing 8 203486_s_at -1.2 203486_s_at -1.3 ARRB1 arrestin, beta 1 43511_s_at -1.2 221861_at -1.1 ATF3 activating transcription factor 3 202672_s_at 11.9 202672_s_at 10.8 ATXN1 ataxin 1 203232_s_at -1.4 203232_s_at -1.5 AVL9 AVL9 homolog (S. cerevisiase) 212474_at -1.5 212474_at -1.4 BAG3 BCL2-associated athanogene 3 217911_s_at 3.3 217911_s_at 3.0 BCL2A1 BCL2-related protein A1 205681_at 4.5 205681_at 2.9 BCL3 B-cell CLL/lymphoma 3 204908_s_at 2.2 204908_s_at 1.8
BHLHE40 basic helix-loop-helix family, member e40
201170_s_at 3.0 201170_s_at 2.9
BIRC3 baculoviral IAP repeat containing 3
210538_s_at 7.3 210538_s_at 4.6
BMP2 bone morphogenetic protein 2 205290_s_at 2.1 205289_at 2.0
BTG2 BTG family, member 2 201236_s_at 2.5 201235_s_at 1.6 BTG3 BTG family, member 3 205548_s_at 1.9 205548_s_at 1.6
C14orf132 chromosome 14 open reading frame 132
218820_at -1.6 218820_at -1.7
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
202715_at -1.2 202715_at -1.5
CBX5 chromobox homolog 5 212126_at -1.6 212126_at -1.5
CCDC121 coiled-coil domain containing 121
220321_s_at -1.3 220321_s_at -1.3
CCDC93 coiled-coil domain containing 93
209688_s_at -1.5 209688_s_at -1.9
CCL20 chemokine (C-C motif) ligand 20
205476_at 10.8 205476_at 5.6
CCL3 chemokine (C-C motif) ligand 3
205114_s_at 4.5 205114_s_at 5.2
CCL4 chemokine (C-C motif) ligand 4
204103_at 7.5 204103_at 7.2
CD160 CD160 molecule 207840_at -1.5 207840_at -1.3
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
201925_s_at 2.2 201925_s_at 1.5
CD59 CD59 molecule, complement regulatory protein
212463_at -1.3 212463_at -1.4
CD83 CD83 molecule 204440_at 3.0 204440_at 2.6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
202284_s_at 2.7 202284_s_at 2.0
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
212501_at 1.5 212501_at 1.4
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
203973_s_at 2.0 203973_s_at 1.9
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
207980_s_at 2.2 207980_s_at 2.9
CKS2 CDC28 protein kinase regulatory subunit 2
204170_s_at 2.7 204170_s_at 3.1
CLCN3 chloride channel, voltage-sensitive 3
201732_s_at -1.5 201735_s_at -1.5
CLMN calmin (calponin-like, transmembrane)
213839_at -2.4 213839_at -2.4
CLTC clathrin, heavy chain (Hc) 200614_at -1.5 200614_at -1.4 COPB1 coatomer protein complex, 201359_at -1.4 201359_at -1.3
subunit beta 1 CPD carboxypeptidase D 201941_at -1.3 201941_at -1.3 CUL3 cullin 3 201370_s_at -1.4 201371_s_at -1.4
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
204470_at 4.6 204470_at 2.9
CXCL3 chemokine (C-X-C motif) ligand 3
207850_at 5.0 207850_at 3.6
CXCL8 chemokine (C-X-C motif) ligand 8
202859_x_at 12.2 202859_x_at 7.5
CXCR4 chemokine (C-X-C motif) receptor 4
217028_at 2.4 209201_x_at 1.6
CYR61 cysteine-rich, angiogenic inducer, 61
201289_at 3.1 201289_at 3.6
DCP2 decapping mRNA 2 212919_at -1.7 212919_at -2.0
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
218198_at -1.2 218198_at -1.2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
200666_s_at 3.8 200666_s_at 4.3
DPH5 diphthamide biosynthesis 5 222360_at -1.2 219590_x_at -1.2 DUSP10 dual specificity phosphatase 10 215501_s_at 2.0 215501_s_at 2.6 DUSP2 dual specificity phosphatase 2 204794_at 2.1 204794_at 1.8 DUSP3 dual specificity phosphatase 3 201536_at -1.3 201536_at -1.3 DUSP5 dual specificity phosphatase 5 209457_at 3.4 209457_at 4.0 EGR1 early growth response 1 201693_s_at 3.6 201693_s_at 3.6 EGR2 early growth response 2 205249_at 4.6 205249_at 4.5
EIF1 eukaryotic translation initiation factor 1
212130_x_at 1.3 212227_x_at 1.3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
210827_s_at 2.4 210827_s_at 2.2
ELL elongation factor RNA polymerase II
204096_s_at 1.2 204096_s_at 1.2
ELL2 elongation factor, RNA polymerase II, 2
214446_at 1.7 214446_at 1.5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
201329_s_at 2.3 201329_s_at 2.1
FAM172A family with sequence similarity 172, member A
212936_at -1.7 212936_at -1.7
FAM178A family with sequence similarity 178, member A
203482_at -1.5 203482_at -1.5
FAM46A family with sequence similarity 46, member A
221766_s_at 2.6 221766_s_at 1.8
FAM46C family with sequence similarity 220306_at 1.7 220306_at 1.6
46, member C
FANCC Fanconi anemia, complementation group C
205189_s_at -1.4 205189_s_at -1.4
FEM1C fem-1 homolog c (C. elegans) 213341_at 1.6 213341_at 1.8
FOS FBJ murine osteosarcoma viral oncogene homolog
209189_at 5.6 209189_at 5.5
FOSL2 FOS-like antigen 2 218880_at 2.8 218880_at 2.5 FZD4 frizzled class receptor 4 218665_at -1.5 218665_at -1.3
GADD45A growth arrest and DNA-damage-inducible, alpha
203725_at 1.9 203725_at 1.7
GADD45B growth arrest and DNA-damage-inducible, beta
209305_s_at 4.4 209305_s_at 4.5
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
212256_at -1.4 207357_s_at -1.2
GCLM glutamate-cysteine ligase, modifier subunit
203925_at 1.2 203925_at 1.3
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
212139_at -1.5 212139_at -1.5
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
208914_at -1.4 208914_at -1.3
GLUL glutamate-ammonia ligase 200648_s_at 1.5 200648_s_at 1.5 GPR183 G protein-coupled receptor 183 205419_at 3.3 205419_at 2.8
GTDC1 glycosyltransferase-like domain containing 1
219770_at -1.2 219770_at -1.2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
210164_at 1.8 210164_at 1.7
GZMK granzyme K (granzyme 3; tryptase II)
206666_at -1.6 206666_at -1.3
HBA1/HBA2 hemoglobin, alpha 1 217414_x_at 2.4 217414_x_at 2.7
HBEGF heparin-binding EGF-like growth factor
203821_at 2.5 203821_at 2.2
HCAR3 hydroxycarboxylic acid receptor 3
205220_at 3.3 205220_at 2.8
HDAC4 histone deacetylase 4 204225_at -1.3 204225_at -1.7
HILPDA hypoxia inducible lipid droplet-associated
218507_at 1.6 218507_at 1.4
HSPA1A/HSPA1B heat shock 70kDa protein 1A 202581_at 12.6 202581_at 11.4
HSPH1 heat shock 105kDa/110kDa protein 1
206976_s_at 2.7 208744_x_at 2.4
HTT huntingtin 202389_s_at -1.2 202390_s_at -1.2 ICAM1 intercellular adhesion molecule 202638_s_at 4.5 202638_s_at 3.1
1 IER2 immediate early response 2 202081_at 2.9 202081_at 2.1 IER3 immediate early response 3 201631_s_at 3.5 201631_s_at 2.2 IER5 immediate early response 5 218611_at 2.6 218611_at 2.1 IL1B interleukin 1, beta 39402_at 3.3 39402_at 3.1
IL1RN interleukin 1 receptor antagonist
212657_s_at 5.4 212657_s_at 5.0
IL6 interleukin 6 205207_at 2.8 205207_at 2.0 INHBA inhibin, beta A 210511_s_at 1.5 210511_s_at 1.5 IPO5 importin 5 211954_s_at -1.5 211954_s_at -1.4
ITPKC inositol-trisphosphate 3-kinase C
213076_at 1.9 213076_at 1.4
IVNS1ABP influenza virus NS1A binding protein
206245_s_at 1.6 206245_s_at 1.8
JMJD6 jumonji domain containing 6 212723_at 1.8 212722_s_at 1.6 JUN jun proto-oncogene 201466_s_at 5.4 201466_s_at 6.1 JUNB jun B proto-oncogene 201473_at 2.5 201473_at 2.1 JUND jun D proto-oncogene 203752_s_at 2.8 203752_s_at 3.4
KCNE4 potassium voltage-gated channel, Isk-related family, member 4
222379_at 2.1 222379_at 1.6
KHNYN KH and NYN domain containing
212356_at -1.4 212356_at -1.6
KIAA0100 KIAA0100 201729_s_at -1.8 201728_s_at -1.5 KLF2 Kruppel-like factor 2 219371_s_at 2.3 219371_s_at 2.2 KLF4 Kruppel-like factor 4 (gut) 221841_s_at 3.4 221841_s_at 3.1 KLF6 Kruppel-like factor 6 208961_s_at 4.0 208961_s_at 4.6 KLF9 Kruppel-like factor 9 203542_s_at 1.6 203542_s_at 1.7 KLHDC10 kelch domain containing 10 209256_s_at -1.8 209256_s_at -1.5
KRAS Kirsten rat sarcoma viral oncogene homolog
214352_s_at 1.3 214352_s_at 1.3
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
205269_at 1.7 205270_s_at 1.3
LINC00341 long intergenic non-protein coding RNA 341
219563_at -1.9 219563_at -2.1
LOC102724428/SIK1 salt-inducible kinase 1 208078_s_at 3.4 208078_s_at 4.2
LOC103344931 uncharacterized LOC103344931
213739_at -1.2 213739_at -1.3
LRPPRC leucine-rich pentatricopeptide repeat containing
211615_s_at -1.3 211615_s_at -1.3
LRRC37A3 (includes others)
leucine rich repeat containing 37, member A3
221740_x_at -1.4 221740_x_at -1.6
MAFF v-maf avian 36711_at 8.0 36711_at 5.0
musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A2 mannosidase, alpha, class 1A, member 2
217922_at -1.4 217922_at -1.3
MAP2K3 mitogen-activated protein kinase kinase 3
215498_s_at 1.5 215499_at 1.3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
205027_s_at 2.8 205027_s_at 3.0
MAP3K9 mitogen-activated protein kinase kinase kinase 9
213927_at -1.3 213927_at -1.5
MARCKS myristoylated alanine-rich protein kinase C substrate
201670_s_at 1.5 201670_s_at 1.9
METTL3 methyltransferase like 3 209265_s_at -1.4 209265_s_at -1.3
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
212098_at -1.2 212098_at -1.5
MIEF1 mitochondrial elongation factor 1
204594_s_at -1.6 204594_s_at -1.5
MORF4L1 mortality factor 4 like 1 217982_s_at -1.1 217982_s_at -1.1
MRPL3 mitochondrial ribosomal protein L3
208787_at -1.2 208787_at -1.2
MTDH metadherin 212248_at -1.4 212248_at -1.2
MYC v-myc avian myelocytomatosis viral oncogene homolog
202431_s_at 3.8 202431_s_at 3.7
NAMPT nicotinamide phosphoribosyltransferase
217739_s_at 1.5 217739_s_at 1.4
NF2 neurofibromin 2 (merlin) 218915_at -1.3 218915_at -1.3
NFIL3 nuclear factor, interleukin 3 regulated
203574_at 2.8 203574_at 2.6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
201502_s_at 2.3 201502_s_at 2.1
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
218133_s_at -1.3 218133_s_at -1.2
NOTCH2 notch 2 202443_x_at -1.6 202443_x_at -1.6
NR4A2 nuclear receptor subfamily 4, group A, member 2
216248_s_at 5.6 216248_s_at 7.1
NRBF2 nuclear receptor binding factor 2
221803_s_at 1.4 221803_s_at 1.5
OPA1 optic atrophy 1 (autosomal dominant)
212214_at -1.5 212214_at -1.4
PDK3 pyruvate dehydrogenase kinase, isozyme 3
206347_at -1.3 221957_at -1.2
PDXK pyridoxal (pyridoxine, vitamin 218019_s_at -1.8 218019_s_at -2.2
B6) kinase
PELI1 pellino E3 ubiquitin protein ligase 1
218319_at 2.3 218319_at 1.8
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
202464_s_at 3.2 202464_s_at 2.5
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
201080_at -1.4 201081_s_at -1.2
PLAUR plasminogen activator, urokinase receptor
210845_s_at 3.1 210845_s_at 1.9
PLK2 polo-like kinase 2 201939_at 3.0 201939_at 2.6
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
204285_s_at 2.9 204285_s_at 3.2
PNRC1 proline-rich nuclear receptor coactivator 1
209034_at 1.8 209034_at 1.6
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
201803_at -1.4 201803_at -1.4
PPAP2B phosphatidic acid phosphatase type 2B
209355_s_at 1.6 212226_s_at 1.4
PPARD peroxisome proliferator-activated receptor delta
37152_at 1.6 37152_at 1.4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
37028_at 2.0 37028_at 1.9
PPP1R7 protein phosphatase 1, regulatory subunit 7
201213_at -1.3 201213_at -1.3
PREPL prolyl endopeptidase-like 212217_at -1.8 212216_at -1.5
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
209799_at 1.3 209799_at 1.2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
204748_at 7.3 204748_at 5.7
PTP4A1 protein tyrosine phosphatase type IVA, member 1
200730_s_at 2.1 200730_s_at 3.0
RARS arginyl-tRNA synthetase 201330_at -1.2 201330_at -1.2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
204346_s_at 1.3 204346_s_at 1.4
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
216215_s_at -1.5 216215_s_at -1.4
RGS2 regulator of G-protein signaling 2
202388_at 2.9 202388_at 2.4
RHOB ras homolog family member B 212099_at 1.9 212099_at 2.2
RIPK2 receptor-interacting serine-threonine kinase 2
209545_s_at 1.8 209545_s_at 1.5
RND1 Rho family GTPase 1 210056_at 6.5 210056_at 4.4 RNF14 ring finger protein 14 201824_at -1.4 201824_at -1.4
RYBP RING1 and YY1 binding protein
201846_s_at 1.6 201846_s_at 1.5
SBNO1 strawberry notch homolog 1 (Drosophila)
218737_at -1.3 218737_at -1.3
SEC14L1 SEC14-like 1 (S. cerevisiae) 202083_s_at 1.5 202082_s_at 1.3 SEPHS1 selenophosphate synthetase 1 208940_at -1.3 208940_at -1.2 SEPT2 septin 2 200015_s_at -1.2 200015_s_at -1.2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
202627_s_at 4.7 202627_s_at 5.3
SGPL1 sphingosine-1-phosphate lyase 1
212321_at -1.6 212321_at -1.3
SKP1 S-phase kinase-associated protein 1
200719_at -1.2 200719_at -1.3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
201920_at 2.6 201920_at 2.3
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14
216236_s_at 2.4 216236_s_at 1.6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
202499_s_at 4.4 202499_s_at 2.8
SLC30A5 solute carrier family 30 (zinc transporter), member 5
218989_x_at -1.4 218989_x_at -1.3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
219911_s_at 1.5 219911_s_at 1.2
SMG5 SMG5 nonsense mediated mRNA decay factor
34868_at -1.3 212147_at -1.3
SOD2 superoxide dismutase 2, mitochondrial
215078_at 9.0 215078_at 9.1
SPRY2 sprouty homolog 2 (Drosophila)
204011_at 1.7 204011_at 1.5
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
219677_at 2.0 219677_at 1.7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
203217_s_at -1.2 203217_s_at -1.2
STK17B serine/threonine kinase 17b 205214_at 2.6 205214_at 1.7
TBC1D13 TBC1 domain family, member 13
44696_at -1.4 44696_at -1.3
TBC1D16 TBC1 domain family, member 222116_s_at -1.8 222116_s_at -1.9
16
TGIF1 TGFB-induced factor homeobox 1
203313_s_at 2.7 203313_s_at 2.6
TGIF2 TGFB-induced factor homeobox 2
218724_s_at 1.5 218724_s_at 1.4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
212665_at 2.9 212665_at 2.6
TMEM62 transmembrane protein 62 218776_s_at -1.2 218776_s_at -1.2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
202643_s_at 6.5 202643_s_at 6.0
TP53BP2 tumor protein p53 binding protein 2
203120_at 1.8 203120_at 1.7
TRAF3 TNF receptor-associated factor 3
221571_at -1.3 221571_at -1.6
TRAK2 trafficking protein, kinesin binding 2
202125_s_at -1.3 202125_s_at -1.3
TRIB1 tribbles pseudokinase 1 202241_at 3.2 202241_at 3.4
TSC22D2 TSC22 domain family, member 2
204094_s_at 3.2 204094_s_at 2.2
TTC23 tetratricopeptide repeat domain 23
219838_at -1.2 219838_at -1.2
TYMP thymidine phosphorylase 217497_at 1.8 217497_at 1.5
UBE2H ubiquitin-conjugating enzyme E2H
221962_s_at 1.6 221962_s_at 1.6
UBR5 ubiquitin protein ligase E3 component n-recognin 5
208883_at -1.6 208883_at -1.5
UGCG UDP-glucose ceramide glucosyltransferase
204881_s_at 1.6 221765_at 1.7
UNC119B unc-119 homolog B (C. elegans)
202365_at -2.1 202365_at -2.5
UNC13B unc-13 homolog B (C. elegans) 202893_at -1.4 202893_at -1.5 USP46 ubiquitin specific peptidase 46 203870_at -1.5 203870_at -1.3 VNN3 vanin 3 220528_at 2.7 220528_at 2.2 WDR37 WD repeat domain 37 211383_s_at -1.4 211383_s_at -1.6 WDR5B WD repeat domain 5B 219538_at -1.3 219538_at -1.5 WEE1 WEE1 G2 checkpoint kinase 212533_at 2.8 215711_s_at 2.3
WSB2 WD repeat and SOCS box containing 2
201760_s_at -1.4 201760_s_at -1.4
XK X-linked Kx blood group 206698_at -1.4 206698_at -1.4
ZBTB14 zinc finger and BTB domain containing 14
209724_s_at -1.4 209724_s_at -1.3
ZBTB43 zinc finger and BTB domain containing 43
204180_s_at 1.6 204180_s_at 1.4
ZC3H12A zinc finger CCCH-type 218810_at 3.0 218810_at 2.2
containing 12A
ZFAND5 zinc finger, AN1-type domain 5
217741_s_at 2.4 217741_s_at 2.6
ZFP36 ZFP36 ring finger protein 201531_at 2.9 201531_at 2.6
ZFYVE26 zinc finger, FYVE domain containing 26
213073_at -1.4 213073_at -1.4
ZHX3 zinc fingers and homeoboxes 3 217367_s_at -1.8 217367_s_at -1.6 ZNF331 zinc finger protein 331 219228_at 2.3 219228_at 2.5
ZSCAN26 zinc finger and SCAN domain containing 26
213218_at -1.3 213218_at -1.4
Table S2, SDC. Significant canonical pathways for common deregulated genes
Ingenuity Canonical Pathways z-score Molecules Glucocorticoid Receptor Signaling -- JUN,ADRB2,KRAS,HSPA1A/HSPA1B,CCL3,IL1B,P
RKAA1,IL6,NFKBIA,CXCL8,POLR2B,FOS,IL1RN,CEBPB,PTGS2,CDKN1A,CXCL3,SERPINE1,ICAM1
HGF Signaling 1.134 FOS,JUN,KRAS,MAP3K8,PTGS2,CDKN1A,IL6,ELF3,MAP3K9,ETS2
CD40 Signaling 0.816 FOS,JUN,TNFAIP3,PTGS2,MAP2K3,TRAF3,NFKBIA,ICAM1
IL-6 Signaling 3.162 FOS,JUN,KRAS,IL1RN,IL1B,CEBPB,MAP2K3,IL6,NFKBIA,CXCL8
NRF2-mediated Oxidative Stress Response
1.667 FOS,JUN,SOD2,KRAS,JUND,ABCC4,DNAJB1,MAP2K3,GCLM,CUL3,MAFF,JUNB
HMGB1 Signaling 3.000 FOS,JUN,KRAS,IL1B,RHOB,MAP2K3,SERPINE1,IL6,ICAM1,CXCL8
PPAR Signaling -2.333 FOS,JUN,PPARD,KRAS,IL1RN,IL1B,PTGS2,NFKBIA,CITED2
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
-- JUN,KRAS,CEBPD,IL1B,IL6,TRAF3,NFKBIA,FZD4,CXCL8,FOS,MYC,IL1RN,CEBPB,MAP2K3,ICAM1
IL-17 Signaling -- JUN,KRAS,PTGS2,CEBPB,CXCL1,MAP2K3,IL6,CXCL8
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
-- CCL3,IL1B,CXCL1,CCL4,IL6
IL-17A Signaling in Fibroblasts -- FOS,JUN,CEBPD,CEBPB,IL6,NFKBIA Role of IL-17A in Arthritis -- PTGS2,CXCL1,CCL20,MAP2K3,CXCL3,NFKBIA,C
XCL8 Acute Phase Response Signaling 3.317 FOS,JUN,SOD2,KRAS,IL1RN,IL1B,CEBPB,MAP2K
3,SERPINE1,IL6,NFKBIA Role of Tissue Factor in Cancer -- HBEGF,KRAS,CYR61,IL1B,PLAUR,CXCL1,EGR1,
CXCL8,ARRB1 TGF-β Signaling 2.449 FOS,JUN,KRAS,INHBA,TGIF1,MAP2K3,SERPINE1
,BMP2 IL-17A Signaling in Gastric Cells -- FOS,JUN,CXCL1,CCL20,CXCL8 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
-- CCL3,IL1RN,IL1B,CCL4,IL6,CXCL8
Role of IL-17A in Psoriasis -- CXCL1,CCL20,CXCL3,CXCL8 IL-10 Signaling -- FOS,JUN,IL1RN,IL1B,MAP2K3,IL6,NFKBIA TNFR2 Signaling 1.000 FOS,JUN,TNFAIP3,NFKBIA,BIRC3 Toll-like Receptor Signaling 1.633 FOS,JUN,IL1RN,IL1B,TNFAIP3,MAP2K3,NFKBIA TREM1 Signaling 2.646 CD83,CCL3,IL1B,CXCL3,IL6,ICAM1,CXCL8
Cholecystokinin/Gastrin-mediated Signaling
2.828 FOS,JUN,KRAS,IL1RN,IL1B,RHOB,PTGS2,MAP2K3
CD27 Signaling in Lymphocytes -- FOS,JUN,MAP3K8,MAP2K3,NFKBIA,MAP3K9 Granulocyte Adhesion and Diapedesis
-- CXCR4,CCL3,IL1RN,IL1B,CXCL1,CCL20,CXCL3,CCL4,ICAM1,CXCL8
PPARα/RXRα Activation -1.265 JUN,ADCY1,KRAS,IL1B,PRKAA1,ABCA1,MAP2K3,BCL3,IL6,NFKBIA
Hereditary Breast Cancer Signaling
-- POLR2B,KRAS,FANCC,CDKN1A,GADD45B,GADD45A,HDAC4,WEE1
Agranulocyte Adhesion and Diapedesis
-- CXCR4,CCL3,IL1RN,IL1B,CXCL1,CCL20,CXCL3,CCL4,ICAM1,CXCL8
ATM Signaling -- JUN,CBX5,CDKN1A,GADD45B,GADD45A,NFKBIA
Communication between Innate and Adaptive Immune Cells
-- CD83,CCL3,IL1RN,IL1B,CCL4,IL6,CXCL8
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
-- CCL3,IL1B,CXCL1,CCL4
GNRH Signaling 1.414 FOS,JUN,ADCY1,KRAS,MAP3K8,MAP2K3,EGR1,MAP3K9
NF-κB Signaling 1.000 KRAS,IL1RN,IL1B,TNFAIP3,MAP3K8,BMP2,TRAF3,NFKBIA,PELI1
Role of IL-17F in Allergic Inflammatory Airway Diseases
-- IL1B,CXCL1,CCL4,IL6,CXCL8
JAK/Stat Signaling 1.633 FOS,JUN,KRAS,CEBPB,CDKN1A,IL6 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
-- FOS,JUN,IL1RN,IL1B,MAP2K3,BMP2,IL6,NFKBIA,FZD4,BIRC3
TNFR1 Signaling 1.000 FOS,JUN,TNFAIP3,NFKBIA,BIRC3 Cell Cycle: G2/M DNA Damage Checkpoint Regulation
2.000 CDKN1A,SKP1,GADD45A,CKS2,WEE1
IL-8 Signaling 3.000 FOS,JUN,HBEGF,KRAS,RHOB,PTGS2,CXCL1,ICAM1,CXCL8
Molecular Mechanisms of Cancer -- JUN,KRAS,BMP2,NFKBIA,FZD4,BIRC3,FOS,ADCY1,MYC,RHOB,CDKN1A,MAP2K3,PMAIP1
Colorectal Cancer Metastasis Signaling
1.265 FOS,JUN,ADCY1,KRAS,MYC,RHOB,PTGS2,IL6,FZD4,ARRB1
Unfolded protein response -- HSPA1A/HSPA1B,CEBPD,CEBPB,PPP1R15A,HSPH1
ErbB Signaling -- FOS,JUN,HBEGF,KRAS,AREG,MAP2K3 PKCθ Signaling in T Lymphocytes -- FOS,JUN,KRAS,LCP2,MAP3K8,NFKBIA,MAP3K9 RANK Signaling in Osteoclasts -- FOS,JUN,MAP3K8,NFKBIA,MAP3K9,BIRC3 p53 Signaling -- JUN,TP53BP2,CDKN1A,GADD45B,GADD45A,PM
AIP1 Telomerase Signaling 2.000 KRAS,MYC,CDKN1A,HDAC4,ELF3,ETS2
IL-17A Signaling in Airway Cells -- CXCL1,CCL20,CXCL3,IL6,NFKBIA April Mediated Signaling -- FOS,JUN,TRAF3,NFKBIA B Cell Receptor Signaling -- JUN,KRAS,BCL2A1,MAP3K8,MAP2K3,EGR1,NFK
BIA,MAP3K9 Cardiac Hypertrophy Signaling 1.667 JUN,ADCY1,ADRB2,KRAS,RHOB,MAP3K8,MAP2
K3,IL6,MAP3K9 B Cell Activating Factor Signaling -- FOS,JUN,TRAF3,NFKBIA Neurotrophin/TRK Signaling 1.342 FOS,JUN,KRAS,SPRY2,MAP2K3 GADD45 Signaling -- CDKN1A,GADD45B,GADD45A LPS-stimulated MAPK Signaling 2.236 FOS,JUN,KRAS,MAP2K3,NFKBIA Pyridoxal 5'-phosphate Salvage Pathway
-- PRKAA1,MAP3K8,MAP2K3,PDXK,MAP3K9
MIF Regulation of Innate Immunity
2.000 FOS,JUN,PTGS2,NFKBIA
Chemokine Signaling 2.236 FOS,JUN,KRAS,CXCR4,CCL4 Prolactin Signaling 2.000 FOS,JUN,KRAS,MYC,CEBPB VDR/RXR Activation -- PPARD,CEBPB,CDKN1A,GADD45A,KLF4 CXCR4 Signaling 2.449 FOS,JUN,ADCY1,KRAS,CXCR4,RHOB,EGR1 Graft-versus-Host Disease Signaling
-- IL1RN,IL1B,IL6,GZMB
Atherosclerosis Signaling -- CXCR4,IL1RN,IL1B,IL6,ICAM1,CXCL8 Bladder Cancer Signaling -- KRAS,MYC,RASSF1,CDKN1A,CXCL8 HIPPO signaling -- NF2,RASSF1,TP53BP2,PPP1R7,SKP1 Adipogenesis pathway -- CEBPD,CEBPB,EGR2,HDAC4,BMP2,FZD4 Xenobiotic Metabolism Signaling -- KRAS,IL1B,MAP3K8,MAP2K3,HDAC4,IL6,CUL3,
MAP3K9,CITED2 Hepatic Cholestasis -- JUN,ADCY1,IL1RN,IL1B,IL6,NFKBIA,CXCL8 Role of Cytokines in Mediating Communication between Immune Cells
-- IL1RN,IL1B,IL6,CXCL8
Airway Pathology in Chronic Obstructive Pulmonary Disease
-- CXCL3,CXCL8
IL-1 Signaling 1.342 FOS,JUN,ADCY1,MAP2K3,NFKBIA SAPK/JNK Signaling -0.447 JUN,DUSP10,KRAS,GADD45A,MAP3K9 Thrombopoietin Signaling 2.000 FOS,JUN,KRAS,MYC Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
1.890 FOS,JUN,RHOB,MAP3K8,PPP1R7,NFKBIA,MAP3K9
ILK Signaling 1.890 FOS,JUN,MYC,RHOB,PTGS2,BMP2,PPAP2B Pathogenesis of Multiple Sclerosis -- CCL3,CCL4 ERK/MAPK Signaling 1.890 FOS,KRAS,MYC,PPP1R7,ELF3,DUSP2,ETS2 PCP pathway 1.000 JUN,JUND,FZD4,JUNB T Cell Receptor Signaling -- FOS,JUN,KRAS,LCP2,NFKBIA Aryl Hydrocarbon Receptor Signaling
1.633 FOS,JUN,MYC,IL1B,CDKN1A,IL6
Activation of IRF by Cytosolic Pattern Recognition Receptors
--
JUN,IL6,TRAF3,NFKBIA
ERK5 Signaling 2.000 FOS,KRAS,MYC,MAP3K8 Cell Cycle: G1/S Checkpoint Regulation
-- MYC,CDKN1A,SKP1,HDAC4
Glioblastoma Multiforme Signaling
0.816 KRAS,MYC,NF2,RHOB,CDKN1A,FZD4
TWEAK Signaling -- TRAF3,NFKBIA,BIRC3 Hepatic Fibrosis / Hepatic Stellate Cell Activation
-- IL1B,KLF6,CXCL3,SERPINE1,IL6,ICAM1,CXCL8
Protein Ubiquitination Pathway -- ANAPC5,USP46,HSPA1A/HSPA1B,UBE2H,DNAJB1,SKP1,HSPH1,BIRC3
Erythropoietin Signaling -- FOS,JUN,KRAS,NFKBIA G-Protein Coupled Receptor Signaling
-- ADCY1,ADRB2,KRAS,HCAR3,MAP3K8,RGS2,ADORA3,NFKBIA
Germ Cell-Sertoli Cell Junction Signaling
-- KRAS,RHOB,MAP3K8,MAP2K3,MAP3K9,PPAP2B
CCR5 Signaling in Macrophages -- FOS,JUN,CCL3,CCL4 Small Cell Lung Cancer Signaling -- MYC,PTGS2,TRAF3,NFKBIA STAT3 Pathway -- KRAS,MYC,CDKN1A,MAP3K9 p38 MAPK Signaling 1.342 DUSP10,MYC,IL1RN,IL1B,MAP2K3 Role of PKR in Interferon Induction and Antiviral Response
-- MAP2K3,TRAF3,NFKBIA
Corticotropin Releasing Hormone Signaling
-- FOS,JUN,ADCY1,JUND,PTGS2
Thyroid Cancer Signaling -- KRAS,MYC,CXCL1 Cyclins and Cell Cycle Regulation -- CDKN1A,SKP1,HDAC4,WEE1 Protein Kinase A Signaling -- DUSP10,ADCY1,ANAPC5,DUSP5,DUSP3,PTP4A1,
PTGS2,PPP1R7,NFKBIA,DUSP2 UVC-Induced MAPK Signaling -- FOS,JUN,KRAS Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
-- FOS,JUN,KRAS,NFKBIA
LXR/RXR Activation -1.342 IL1RN,IL1B,PTGS2,ABCA1,IL6 PI3K/AKT Signaling 1.342 KRAS,MAP3K8,PTGS2,CDKN1A,NFKBIA PDGF Signaling 2.000 FOS,JUN,KRAS,MYC Dendritic Cell Maturation -- CD83,IL1RN,IL1B,IL6,NFKBIA,ICAM1 P2Y Purigenic Receptor Signaling Pathway
1.342 FOS,JUN,ADCY1,KRAS,MYC
Huntington's Disease Signaling -- JUN,POLR2B,HSPA1A/HSPA1B,HTT,DNAJB1,CLTC,HDAC4
RAR Activation -- FOS,JUN,ADCY1,PNRC1,BMP2,CITED2 iNOS Signaling -- FOS,JUN,NFKBIA PI3K Signaling in B Lymphocytes -- FOS,JUN,KRAS,NFKBIA,ATF3 Altered T Cell and B Cell -- IL1RN,IL1B,IL6,TRAF3
Signaling in Rheumatoid Arthritis Endothelin-1 Signaling 2.449 FOS,JUN,ADCY1,KRAS,MYC,PTGS2 Sertoli Cell-Sertoli Cell Junction Signaling
-- JUN,KRAS,MAP3K8,MAP2K3,MAP3K9,PPAP2B
UVA-Induced MAPK Signaling -- FOS,JUN,TIPARP,KRAS Apoptosis Signaling -1.000 KRAS,BCL2A1,NFKBIA,BIRC3 IL-12 Signaling and Production in Macrophages
-- FOS,JUN,MAP3K8,CEBPB,JMJD6
Neuregulin Signaling 2.000 HBEGF,KRAS,AREG,MYC Chronic Myeloid Leukemia Signaling
-- KRAS,MYC,CDKN1A,HDAC4
IL-2 Signaling -- FOS,JUN,KRAS IGF-1 Signaling -- FOS,JUN,KRAS,CYR61 Lymphotoxin β Receptor Signaling -- CXCL1,TRAF3,NFKBIA ErbB2-ErbB3 Signaling -- JUN,KRAS,MYC Glioma Invasiveness Signaling -- KRAS,RHOB,PLAUR CDK5 Signaling 1.000 ADCY1,KRAS,PPP1R7,EGR1 Polyamine Regulation in Colon Cancer
-- KRAS,MYC
Induction of Apoptosis by HIV1 -- CXCR4,NFKBIA,BIRC3 Tumoricidal Function of Hepatic Natural Killer Cells
-- ICAM1,GZMB
Estrogen-mediated S-phase Entry -- MYC,CDKN1A Pancreatic Adenocarcinoma Signaling
2.000 HBEGF,KRAS,PTGS2,CDKN1A
Aldosterone Signaling in Epithelial Cells
-- KRAS,HSPA1A/HSPA1B,DNAJB1,PIP4K2B,HSPH1
Type I Diabetes Mellitus Signaling -- IL1B,MAP2K3,NFKBIA,GZMB Role of BRCA1 in DNA Damage Response
-- FANCC,CDKN1A,GADD45A
Salvage Pathways of Pyrimidine Ribonucleotides
-- PRKAA1,MAP3K8,MAP2K3,MAP3K9
Hypoxia Signaling in the Cardiovascular System
-- JUN,UBE2H,NFKBIA
Systemic Lupus Erythematosus Signaling
-- FOS,JUN,KRAS,IL1RN,IL1B,IL6
Gαs Signaling -- ADCY1,ADRB2,HCAR3,RGS2 Mitotic Roles of Polo-Like Kinase -- ANAPC5,PLK2,WEE1 Estrogen-Dependent Breast Cancer Signaling
-- FOS,JUN,KRAS
IL-15 Signaling -- KRAS,IL6,CXCL8 Renin-Angiotensin Signaling 1.000 FOS,JUN,ADCY1,KRAS Signaling by Rho Family GTPases -- FOS,JUN,RHOB,PIP4K2B,SEPT2,MAP3K9 IL-3 Signaling -- FOS,JUN,KRAS Role of MAPK Signaling in the -- KRAS,PTGS2,MAP2K3
Pathogenesis of Influenza GDNF Family Ligand-Receptor Interactions
-- FOS,JUN,KRAS
PEDF Signaling -- SOD2,KRAS,NFKBIA Role of NFAT in Regulation of the Immune Response
2.000 FOS,JUN,KRAS,LCP2,NFKBIA
CD28 Signaling in T Helper Cells -- FOS,JUN,LCP2,NFKBIA Renal Cell Carcinoma Signaling -- FOS,JUN,KRAS 4-1BB Signaling in T Lymphocytes
-- JUN,NFKBIA
Regulation of the Epithelial-Mesenchymal Transition Pathway
-- KRAS,MAP2K3,EGR1,NOTCH2,FZD4
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
-- IL1B,RIPK2,IL6,CXCL8
HER-2 Signaling in Breast Cancer -- KRAS,AREG,CDKN1A Phospholipase C Signaling 2.000 ADCY1,KRAS,LCP2,RHOB,HDAC4,MARCKS Role of NFAT in Cardiac Hypertrophy
1.342 ADCY1,KRAS,MAP2K3,HDAC4,IL6
Acute Myeloid Leukemia Signaling
-- KRAS,MYC,MAP2K3
BMP signaling pathway -- JUN,KRAS,BMP2 Ovarian Cancer Signaling -- KRAS,PTGS2,FZD4,ARRB1 Coagulation System -- PLAUR,SERPINE1 MIF-mediated Glucocorticoid Regulation
-- PTGS2,NFKBIA
Ceramide Signaling -- FOS,JUN,KRAS Complement System -- CD59,CD55 Prostate Cancer Signaling -- KRAS,CDKN1A,NFKBIA Relaxin Signaling -- FOS,JUN,ADCY1,NFKBIA OX40 Signaling Pathway -- JUN,TRAF3,NFKBIA Glutamine Biosynthesis I -- GLUL AMPK Signaling 2.000 ADRB2,PFKFB3,PRKAA1,MAP2K3 Death Receptor Signaling -- TIPARP,NFKBIA,BIRC3 Superpathway of Inositol Phosphate Compounds
-- DUSP10,PIP4K2B,PPP1R7,ITPKC,DUSP2
Melanoma Signaling -- KRAS,CDKN1A Virus Entry via Endocytic Pathways
-- KRAS,CLTC,CD55
Mouse Embryonic Stem Cell Pluripotency
-- KRAS,MYC,FZD4
Role of RIG1-like Receptors in Antiviral Innate Immunity
-- TRAF3,NFKBIA
Docosahexaenoic Acid (DHA) Signaling
-- IL1B,BCL2A1
Superoxide Radicals Degradation -- SOD2 G Beta Gamma Signaling -- ADCY1,HBEGF,KRAS cAMP-mediated signaling -0.447 ADCY1,ADRB2,HCAR3,RGS2,ADORA3 LPS/IL-1 Mediated Inhibition of RXR Function
2.000 JUN,IL1RN,ABCC4,IL1B,ABCA1
HIF1α Signaling -- JUN,KRAS,SLC2A3 Hematopoiesis from Pluripotent Stem Cells
-- IL6,CXCL8
3-phosphoinositide Biosynthesis -- DUSP10,PIP4K2B,PPP1R7,DUSP2 Rac Signaling -- JUN,KRAS,PIP4K2B Wnt/β-catenin Signaling -- JUN,PPARD,MYC,FZD4 Semaphorin Signaling in Neurons -- RHOB,RND1 UVB-Induced MAPK Signaling -- FOS,JUN Glutathione Biosynthesis -- GCLM Endometrial Cancer Signaling -- KRAS,MYC Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
-- KRAS,BMP2,FZD4
NGF Signaling -- KRAS,MAP3K8,MAP3K9 Actin Nucleation by ARP-WASP Complex
-- KRAS,RHOB
Androgen Signaling -- JUN,POLR2B,DNAJB1 Diphthamide Biosynthesis -- DPH5 NAD Biosynthesis III -- NAMPT Fc Epsilon RI Signaling -- KRAS,LCP2,MAP2K3 Myc Mediated Apoptosis Signaling
-- KRAS,MYC
Gα12/13 Signaling -- JUN,KRAS,NFKBIA 14-3-3-mediated Signaling -- FOS,JUN,KRAS EGF Signaling -- FOS,JUN EIF2 Signaling -- KRAS,AGO1,PPP1R15A,EIF1 Gαi Signaling -- ADCY1,KRAS,ADORA3 GM-CSF Signaling -- KRAS,BCL2A1 Prostanoid Biosynthesis -- PTGS2 Synaptic Long Term Potentiation -- ADCY1,KRAS,PPP1R7 Estrogen Receptor Signaling -- POLR2B,KRAS,RBFOX2 Breast Cancer Regulation by Stathmin1
-- ADCY1,KRAS,PPP1R7,CDKN1A
Granzyme B Signaling -- GZMB Glycogen Degradation II -- TYMP Selenocysteine Biosynthesis II (Archaea and Eukaryotes)
-- SEPHS1
Antiproliferative Role of Somatostatin Receptor 2
-- KRAS,CDKN1A
Angiopoietin Signaling -- KRAS,NFKBIA D-myo-inositol (1,4,5,6)- -- DUSP10,PPP1R7,DUSP2
Tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis
-- DUSP10,PPP1R7,DUSP2
Agrin Interactions at Neuromuscular Junction
-- JUN,KRAS
Non-Small Cell Lung Cancer Signaling
-- KRAS,RASSF1
Glycogen Degradation III -- TYMP Type II Diabetes Mellitus Signaling
-- PRKAA1,CEBPB,NFKBIA
Basal Cell Carcinoma Signaling -- BMP2,FZD4 Human Embryonic Stem Cell Pluripotency
-- INHBA,BMP2,FZD4
RAN Signaling -- IPO5 Uridine-5'-phosphate Biosynthesis -- CAD Fatty Acid α-oxidation -- PTGS2 Caveolar-mediated Endocytosis Signaling
-- CD55,COPB1
NF-κB Activation by Viruses -- KRAS,NFKBIA Cardiomyocyte Differentiation via BMP Receptors
-- BMP2
Salvage Pathways of Pyrimidine Deoxyribonucleotides
-- TYMP
Vitamin-C Transport -- SLC2A3 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell
-- ADCY1,ADRB2
Regulation of eIF4 and p70S6K Signaling
-- KRAS,AGO1,EIF1
D-myo-inositol-5-phosphate Metabolism
-- DUSP10,PPP1R7,DUSP2
3-phosphoinositide Degradation -- DUSP10,PPP1R7,DUSP2 VEGF Family Ligand-Receptor Interactions
-- FOS,KRAS
eNOS Signaling -- ADCY1,HSPA1A/HSPA1B,PRKAA1 Gαq Signaling -- RHOB,RGS2,NFKBIA Melanocyte Development and Pigmentation Signaling
-- ADCY1,KRAS
Role of JAK family kinases in IL-6-type Cytokine Signaling
-- IL6
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis
-- ITPKC
CTLA4 Signaling in Cytotoxic T Lymphocytes
-- LCP2,CLTC
Antiproliferative Role of TOB in T -- SKP1
Cell Signaling Crosstalk between Dendritic Cells and Natural Killer Cells
-- CD83,IL6
IL-15 Production -- IL6 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian)
-- ITPKC
TR/RXR Activation -- BCL3,KLF9 Factors Promoting Cardiogenesis in Vertebrates
-- BMP2,FZD4
Dopamine Receptor Signaling -- ADCY1,PPP1R7 Regulation of Actin-based Motility by Rho
-- RHOB,PIP4K2B
γ-glutamyl Cycle -- GCLM α-Adrenergic Signaling -- ADCY1,KRAS VEGF Signaling -- KRAS,EIF1 Glioma Signaling -- KRAS,CDKN1A Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
-- GZMB
Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism
-- ITPKC
CREB Signaling in Neurons -- ADCY1,POLR2B,KRAS Antioxidant Action of Vitamin C -- SLC2A3,NFKBIA IL-9 Signaling -- BCL3 Oncostatin M Signaling -- KRAS Circadian Rhythm Signaling -- BHLHE40 Cell Cycle Regulation by BTG Family Proteins
-- BTG2
Nucleotide Excision Repair Pathway
-- POLR2B
Amyotrophic Lateral Sclerosis Signaling
-- GLUL,BIRC3
Retinoate Biosynthesis I -- BMP2 D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis
-- PIP4K2B
Notch Signaling -- NOTCH2 iCOS-iCOSL Signaling in T Helper Cells
-- LCP2,NFKBIA
Sphingosine-1-phosphate Signaling
-- ADCY1,RHOB
mTOR Signaling -- KRAS,RHOB,PRKAA1 Inhibition of Angiogenesis by TSP1
-- JUN
Natural Killer Cell Signaling -- KRAS,LCP2 fMLP Signaling in Neutrophils -- KRAS,NFKBIA
Thrombin Signaling -- ADCY1,KRAS,RHOB PTEN Signaling -- KRAS,CDKN1A RhoA Signaling -- PIP4K2B,SEPT2 FcγRIIB Signaling in B Lymphocytes
-- KRAS
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
-- ETS2
Triacylglycerol Biosynthesis -- PPAP2B Assembly of RNA Polymerase II Complex
-- POLR2B
Autoimmune Thyroid Disease Signaling
-- GZMB
Pyrimidine Ribonucleotides De Novo Biosynthesis
-- CAD
CNTF Signaling -- KRAS FXR/RXR Activation -- IL1RN,IL1B Insulin Receptor Signaling -- KRAS,PPP1R7 Serotonin Receptor Signaling -- ADCY1 Cardiac β-adrenergic Signaling -- ADCY1,PPP1R7 Role of CHK Proteins in Cell Cycle Checkpoint Control
-- CDKN1A
Regulation of Cellular Mechanics by Calpain Protease
-- KRAS
Epithelial Adherens Junction Signaling
-- KRAS,NOTCH2
Wnt/Ca+ pathway -- FZD4 ErbB4 Signaling -- KRAS Role of JAK1 and JAK3 in γc Cytokine Signaling
-- KRAS
Axonal Guidance Signaling -- KRAS,CXCR4,BMP2,FZD4,RND1 Glutamate Receptor Signaling -- GLUL Tec Kinase Signaling -- FOS,RHOB Retinoic acid Mediated Apoptosis Signaling
-- TIPARP
Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
-- NFKBIA
Macropinocytosis Signaling -- KRAS Tight Junction Signaling -- FOS,JUN Gap Junction Signaling -- ADCY1,KRAS Cdc42 Signaling -- FOS,JUN PXR/RXR Activation -- IL6 T Helper Cell Differentiation -- IL6 Growth Hormone Signaling -- FOS GABA Receptor Signaling -- ADCY1 FLT3 Signaling in Hematopoietic -- KRAS
Progenitor Cells Ephrin B Signaling -- CXCR4 Dopamine-DARPP32 Feedback in cAMP Signaling
-- ADCY1,PPP1R7
Melatonin Signaling -- MAP2K3 Ephrin Receptor Signaling -- KRAS,CXCR4 Leptin Signaling in Obesity -- ADCY1 IL-4 Signaling -- KRAS RhoGDI Signaling -- RHOB,PIP4K2B Reelin Signaling in Neurons -- MAP3K9 Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza
-- FZD4
Eicosanoid Signaling -- PTGS2 tRNA Charging -- RARS Clathrin-mediated Endocytosis Signaling
-- CLTC,ARRB1
Allograft Rejection Signaling -- GZMB FGF Signaling -- MAP2K3 FAK Signaling -- KRAS PAK Signaling -- KRAS GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
-- ADCY1