TCIASustainmentandScalability–PlatformsforQuantitativeImagingInformaticsinPrecisionMedicine

11/3/2017

FredPrior,PhDUniversityofArkansasforMedicalSciences

JoelSaltz,MD,PhDStonyBrookUniversity

Ashish Sharma,PhDEmoryUniversity

Overview• PrecisionMedicinerequirestheabilitytoclassifypatientsintospecializedcohortsthatdifferintheir

susceptibilitytodisease,inthebiologyand/orprognosisofthediseasestheydevelop,orintheirresponsetotherapy.Identifyingquantitativeimagingphenotypesacrossscalethroughtheuseofradiomic/pathomicanalysesisanevolvingapproachtocohortidentificationandtoimprovingourunderstandingofcancerbiology.Theseanalytictechniquesrequirelargecollectionsofwell-curateddataforalgorithmtestingandvalidation.

• Since2011theCancerImagingArchive(TCIA)hasencouragedandsupportedcancer-relatedopenscienceresearchbyacquiring,curating,hostingandmanagingcollectionsofmulti-modalinformation.ToremainrelevanttoitscurrentresearchcommunityTCIAmustundergocontinuousimprovementandexpansionofitcapabilitiesguidedbytheresearchcommunity.

• TheTCIAusercommunityhasidentifiedfourcriticalareasforimprovement:– expandedresourcesforintegrativeImage-Omics studies,– enhancedcapacitytoacquirehighqualitydatacollections,– resourcestosupportvalidationstudiesandResearchReproducibility,– increasedcommunityengagement.

SpecificAims• Aim1:DeployexpandedresourcesforIntegrativeImage-Omics Studies.– expandedcapabilitiesindatadriveninformationintegration,semanticquerycapabilityandfeaturemanagement

• Aim2:Increasecapacitytoacquirehighqualitydatacollections.– extendandautomatecurationprocessestoincreaseTCIA’scollectionsandaddnewtypesofdatabasedonprioritiesestablishedbyourResearchAdvisoryCommittee

– consolidatetheTCIAsoftwarestackintoasetofeasilydeployableentitiestoreduceTCIA’slong-terminternaloperationalcosts

• Aim3:Enhanceresourcestosupportvalidationstudiesandresearchreproducibility.– deployasetoftoolsandcapabilitiestodirectlysupportITCRimaginggrandchallenges

• AIM4:EmphasizeCommunityEngagement,CollaborationandDissemination.– ResearchAdvisoryCommitteewillbecreatedtoprovidedirectcommunityguidanceonTCIAenhancementandcollectionpriorities.

ResearchAdvisoryCommittee• ThisgroupofexpertswillprovidedirectcommunityguidanceonTCIAenhancementsandcollectionpriorities.

• Dr.TJFitzgeraldhasagreedtochairtheRACandthefollowingseniorscientistshaveagreedtoparticipate:– Dr.MichaelMcNitt-Gray(UCLA),– Dr.Jayashree Kalpathy-Cramer(Harvard),– Dr.Metin Gurcan (OSU),– Dr.SamuelAchilefu (WashingtonUniversity),– Dr.HugoAerts (Harvard).– NCIwillalsoprovidealiaisontotheRAC.

ImageDerivedFeatures

• Annotations,Segmentations,RadiomicsfeaturesetsarebeingsubmittedtoTCIA

• Currentmanagementmechanismsonlysupportdiscoveryanddownload

• Growingneedforafeatureontologyanda“featurebase”

EvolvingtheRepositoryArchitecture

TCIADistributedObjectStore

UAMS

AWS

Emory

Google

Stoneybrook

IndexingandSearchEngines AnalyticsEngines

GUIandVisualization(Clients)

DataAccessEngines

OtherRepositories

InSummary

ThesustainmentofTCIAandresearchcommunitydirectedexpansionofitscapabilitieswillensurethisvaluableresourcecontinuestopromoteresearchreproducibilityanddatareuseincancerprecisionmedicalresearch.