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Teachable Tidbit: Cell Signaling—Why should YOU Care?
Mountain West Summer InstituteAugust 3, 2012
Group 1: Cell Biology
Participants: Patrick Burns, Jacquelyn Duke, Diane Hartman, Pamela Harvey, Andrea Stith, and Mark Thomas
Facilitators: Renee Dawson and Robin Wright
Overview
• Topic: Cell signaling and cancer• Context:
– Week-long unit geared toward 100-level biology course for majors and non-majors.
– End of semester – 50 to 100 students
• Prior Knowledge:– Cell structure– Mitosis– Reading assignment on cell signaling
Unit Goals
• Understand that cell signaling regulates cell division
• Understand that defects in cell signaling underlie cancer
Tidbit: Outcomes & Activities
What do these people have in common?
• What IS cancer?
• Will there ever be a cure?
Cell Division and Cancer
Cell DivisionG
o
STOP
___Transduction Pathway___Nuclear Envelope___Plasma Membrane___Growth Factor Receptor___Growth Factor___Tumor Suppressor Gene
Cell DivisionAB
C
D
E
Go
STOP
F
Gene Protein Normal FunctionToo Much
ProteinToo Little
Protein
ErbB2 HER2 Growth Factor Receptor
PDGFR PDGFR Growth Factor Receptor
BRCA1,2 BRCA Tumor Suppressor
TP53 p53 Tumor Suppressor
CHEK-2 CHK2 Tumor Suppressor
Regulators of Cell Division
Summary Assessment Question
Jane recently was diagnosed with breast cancer. The oncologist performed a biopsy and laboratory analysis revealed an increase in HER2 receptors and decreased p53.
You work in a pharmaceutical company and are a genius at drug design. Brainstorm a way to treat Jane’s cancer.
Take home messages:
Appropriate cell signaling is required for normal cell division.
Cancers are caused by defects in cell signaling pathways.
Multiple defects magnify the severity.
Assessment, Alignment, & Diversity
Thank you!
Facilitators,Group Members &
National Academies Summer Institute for your contributions!
Website Citations
• 1 http://trussty-jasmine.blogspot.com/2012/03/stem-cells-can-repair-damaged-corneas.html#axzz22P5vt5SP
• 2 http://www.buyactivatedcharcoal.com/infected_wounds
• 3 http://en.wikipedia.org/wiki/Human_skeleton