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Technical Memorandum Supplemental Clean-Up Goal Evaluation

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Tetra Tech EC Inc 133 Federal Street Boston MA 02110

Submitted by Tetra Tech EC Inc on behalf of Jacobs - Tetra Tech EC Joint Venture Two Center Plaza Boston MA 02108-1906

2008-O-JV03-0008 | 1 1

Tetra Tech EC Inc Supplemental Clean-Up Goal Evaluation Silreslm Superfund Site

TABLE OF CONTENTS

L SITE CHRONOLOGYn REVISED AND UPDATED BENCHMARK ASSESSMENT VALUES AND CLEAN-UP GOALS

1 3

TABLES

Table 1 Chronology of Silresim Site Risk AssessmentManagement Activities Table 2 Non-Cancer Toxicity Data - OralDermal Table 3 Non-Cancer Toxicity Data - Inhalation Table 4 Cancer Toxicity Data - OralDermal Table 5 Cancer Toxicity Data - Inhalation Table 6 Determination of VolatiUty for Application of a Volatilization Factor for the Surface

and Subsurface Soil COCs Table 7 Adult Lead Model Assumptions and Calculations for the CommercialIndustrial Worker Table 8 Adult Lead Model Assumptions and Calculations for the Construction Worker Table 9 Adult Lead Model Assumptions and Calculations for the Trespasser Table 10 Summary of Site-Specific Benchmark Assessment Values (B AVs) and Recommended

Clean-up Goals (CUGs) Table 11 Summary of Site-Specific Benchmark Assessment Values (BAVs) and Recommended

Clean-Up Goals (CUGs) Table 12 Summary of Site-Specific Benchmark Assessment Values (BAVs) and Recommended

Clean-Up Goals (CUGs)

APPENDIX

Appendix A Sample Calculations of Benchmark Assessment Values (BAVs) for Carcinogenic and Non-Carcinogenic Health Effect Endpoints

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Tetra Tech EC Inc Supplemental Clean-Up Goal Evaluation Silresim Superfund Site

Supplemental Clean-Up Goal Evaluation Silresim Superfund Site

April 30 2008

This memorandum summarizes the completion of two additional tasks with regard to the Silresim Superftmd Site (the Site)

I) Developing a chronological summary of the principal risk assessment and risk management activities that have been conducted at or in relation to the Silresim Superfund Site (the Site) over the past few years and

II) Developing and describing revised site-specific risk-based Benchmark Assessment Values (BAVs) and recommended Clean-Up Goals (CUGs) for the Site that reflect a number of updated technical and policy considerations that have arisen since the submittal of the Explanation of Significant Differences (ESD) (USEPA September 2003)

These two tasks are discussed in the sections that follow

I Site Chronology

The Silresim Site has been undergoing active assessment and remedial actions for a number of years Aspects of the risk assessment and risk management approach have been adjusted over this period in response to new information about the Site new regulatory policies and new scientific information regarding contaminant dose-response and risk assessment These adjustments have been overseen by various Remedial Project Managers (RPMs) from the United States Enviroiunental Protection Agency (USEPA) Region 1 and Massachusetts Department of Enviroimiental Protection (MassDEP) On September 13 2005 the RPM requested that a chronology of Site-related risk assessment and risk management activities be compiled Table I presents this chronology The principal risk assessment activities associated with the Site are further highlighted below

Baseline human health and ecological risk assessments were completed in March 1990 as part of the Remedial Investigation (RI) The principal finding of this assessment was the potential risks projected for a number of current and anticipated fiiture users ofthe Site and adjacent properties A Record of Decision (ROD) was written in 1991 In addition vapor intrusion was subsequently identified as a topic to further evaluate relative to the occupied buildings on the Lowell Iron amp Steel (LIampS) property

The 5-Year ROD Review in 1999 identified and highlighted a number of important changes that occurred with respect to the Site that prompted a revision and updating of the Site management approach and the associated CUGs An initial set of revised CUGs was developed in 2001 (Foster Wheeler 2001) These modified CUGs were calculated specifically to be protective of CommercialIndustrial Workers Trespassers Construction Workers and Railroad Workers who may be exposed to impacted soil and groundwater associated with the Site (as applicable) Further discussion by the Site Managers identified additional modifications and adjustments that were warranted The Final Additional Site Investigation and Revision of Site Clean-up Goals issued in January 2002 (Foster Wheeler 2002) hereafter called 2002 CUG Report expanded the focus of the original risk assessments by addressing the potential risks to Child Recreational Users in response to a request from MassDEP The Explanation of Significant Difference (ESD) (USEPA September 2003a) document included a comparison ofthe 2002 CUGs to Site data Applicable or Relevant and Appropriate Requirements (ARARs) and the CUGs that were presented in the original ROD

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Subsequent to the 2002 CUG Report renewed interest in the potential risks to Utility Workers arose and the investigation of potential vapor intrusion into subsurface structures and buildings at the adjacent LIampS property continued In September of 2004 the potential for indoor inhalation and the associated risk to Utility Workers at the LIampS property was evaluated and CUGs were calculated for this receptor group (Tetra Tech FW Inc 2004) In 2005 USEPA Region 1 directed that recreational use of these properties by adults as well as by children also should be evaluated Simultaneously any updates to the toxicity values that were used in the CUG development and any changes associated with updated risk assessment guidance also were to be incorporated into the development of the new values A draft of these revised and updated CUGs was submitted to USEPA Region 1 and MassDEP in late 2005 (Tetra Tech FW Inc 2005a 2005b) Following review USEPA Region 1 transmitted a memo to TtEC (December 6 2007) containing comments and direction regarding revisions and updates to both the BAVs and the recommended CUGs (USEAP 2007b) The principal revisions and updates related to

1 Removing the vapor intrusion component from the BAV calculations for receptors at off-property locations where that potential pathway was an assumed contributor to risk - Additional investigation and evaluation by USEPA Region I was summarized in a Memorandum by J DiLorenzo former USEPA Remedial Project Manager on the Silresim Site (USEPA November 29 2007a) concluded that there is currently not a complete Silresim Site-related indoor air exposure pathway at the BampL Auto Parts location (ie the off-property location nearest and down-gradient of the groundwater contamination other than the LIS facility that was explicitly investigated relative to possible vapor intrusion) The April 14 2008 Property Use Assessment of the LIS property similarly concluded that indoor air migration is not a complete pathway at the multiple LIS facilities In addition this assessment suggested that a periodic review of property use be performed concurrent with the annual MassDEP groundwater sampling and no less than every 5 years by USEPA Subsequently USEPA Region 1 directed that this exposure pathway not be included in the BAV calculations for these off-property receptors

2 Evaluating inhalation risk using the Reference Concentration (RfC) and Inhalation Unit Risk (lUR) toxicity factors instead of the inhalation Reference Doses (RfDs) and inhalation Cancer Slope Factors (CSFs) - Supplemental federal guidance for Superfitnd inhalation risk assessment is currently being drafted to specify that this approach be applied to inhalation risk assessment at CERCLA sites In 1996 (USEPA 1996) and 2002 (USEPA 2002d) USEPA published and then updated the Soil Screening Guidance documents which implement the RfCIUR approach in developing risk-based Soil Screening Levels (SSLs) USEPA Region 1 has adopted this approach for use in inhalation risk assessments and in the development of risk-based clean-up goals The inhalation risk assessment components of the BAVs were borrowed from the corresponding components ofthe earlier baseline risk assessment which used the older approach

The remainder of this memorandum documents the cumulative set of actions that have been taken to revise and update the BAVs and CUGs since the submittal of the ESD docimient (USEPA September 2003)

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II Revised and Updated Benclimarlc Assessment Values and Clean-Up Goals

The CUGs previously established for the surface soil subsurface soil and groundwater at the Site (as described in the 2002 CUG Report and documented in the ESD (USEPA September 2003a) were further revised and updated in various modifications as indicated above Risk-based BAVs represent the starting point of the CUG specification process The contaminant-specific BAVs are the concentration of that contaminant in a particular exposure medium that is projected to correspond to a specified target risk level to an identified receptor group exposed to that medium now or during reasonably anticipated future uses BAVs were calculated for each chemical of potential concern (COPC) based on the potential for them to cause carcinogenic andor non-carcinogenic health effects endpoints The target excess lifetime cancer risk goal specified for individual carcinogenic COPCs was 1 x 10 and the target Hazard Index for non-carcinogenic COPCs was specified to be 1 These BAVs along with several other criteria and published standards will be considered by the Site Managers in the ultimate specification ofthe CUGs for the Site

The following summarizes the changes that were made to the inputs to our approach for calculating the BAVs as a result of the full set of cumulative comments and suggestions received from USEPA Region I during the period 2003 to 2007

1 Modification of the List of Target Receptors for the Site Relative to the Specification of CUGs

Summary Risk-based BAVs and recommended CUGs were calculated to be protective of CommercialIndustrial Workers Trespassers Construction Workers and Utility Workers relative to the Site The BAVs that were developed previously to be protective of Railroad Workers and Aduh and Child Recreational Users were not updated and were not considered in the subsequent updated CUG development process

Discussion In discussions with USEPA Region 1 and the Site Managers it was decided that the recreational scenario was no longer a valid basis on which to develop CUGs for the Site Therefore the BAVs that were calculated for Adult and Child Recreational Users of the Site were removed from the comparison that identified the most stringent BAV calculated for each COPC In addition the occasional risk posed to Raikoad Workers was believed to be adequately addressed by the consideration of Construction Workers and Utility Workers Therefore Railroad Workers also were removed from the basis ofthe revised BAVs and recommended CUGs Since the Utility Worker risk assessment effort (see Table 1) did not include the calculation of CUGs relative to this receptor CUG spreadsheets were developed for Utility Workers using the equations and methods defined in the 2002 CUG Report and the exposure assumptions assumed in the September 2004 Utility Worker risk calculations The evaluation of risk with respect to the Utility Worker considers potential exposures to soil and contaminated groundwater that may be encountered while working in either a trench or an open excavation enviroimient

2 Consideration of Additional Chemicals of Potential Concern (COPCs)

Summary Risk-based BAVs were calculated for 14-dioxane for each ofthe identified receptors relative to their potential exposure to impacted surface soil subsurface soil and groundwater

Discussion Based on the 5-Year Review conducted in 2004 USEPA requested that groundwater influent to the on-site groundwater treatment facility be analyzed for 14-dioxane This constituent was found to be present in the influent at levels above detection limits and therefore was subsequently included as a parameter in influent sampling In June of 2007 USEPA Region 1 determined that 14-dioxane should be included as a COPC for the Site and requested that BAVs and

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CUGs be developed for this COPC CUGs were calculated for 14-dioxane for both soil and groundwater during this current effort

3 Application of Updated Toxicity Values for the Oral and Dermal Pathways

Summary Updated published toxicity values or specific values provided by USEPA Region 1 for certain COPCs were used in the revised BAV calculations and all of the other toxicity values that were used in the previous CUG development effort were checked and updated (if necessary) to be current with the specified hierarchy of sources

Discussion To maintain consistency between the previous CUG evaluations and the current supplemental effort the same methodology and assumptions were used except for the updated toxicological information (see the 2002 CUG Report for the previous evaluation) The non-carcinogenic and carcinogenic toxicity values for each of the COPCs were revised to reflect the most current information and hierarchy of sources The preferred hierarchy currently is

(1) the USEPA Integrated Risk Information System (IRIS) (2) the USEPA Provisional Peer Reviewed Toxicity Values (PPRTVs) and (3) Other Sources (ie CaUfomia Environmental Protection Agency (CalEPA) Agency for

Toxic Substances and Disease Registrys (ATSDR) Minimal Risk Levels (MRLs) and the Health Effects Assessment Summary Tables (HEAST) in that order)

Discussions with the USEPA Region 1 Risk Assessor also provided direction as to which toxicity values should be applied in order to maintain consistency with USEPA Region I protocol The non-carcinogenic and carcinogenic toxicity values for each COPC were reviewed based on the above hierarchy and regional protocols Tables 2 and 4 contain the full set of updated toxicity values for the oral and dermal pathways that were applied in the CUG development It should be noted that these tables list all the constituents that were addressed in the various risk assessments Many of these constituents subsequently did not warrant the development of CUGs The following identifies which toxicity values have been revised relative to the values presented in the November 2005 Report (Note All changed values are shown in bold in Tables 2 and 4)

Non-Cancer Oral Dermal Toxicity Value Changes Since 2005

COPC New Source Chlorobenzene PPRTV n-Propylbenzene USEPA (Now Unquantified - No Value Supported) Toluene IRIS 111 -Trichloroethane IRIS 112-Trichloroethane IRIS 14-Dioxane IRIS (Now Unquantified - No Value Supported) Aluminum PPRTV Barium IRIS

NOTE TTie oraldermal Reference Doses (RfDs) for 11 COPCs had previously been updated in 2005 (Tetra Tech FW Inc 2005b) relative to the values that were used in the 2002 CUG Report These were Acetone Benzene 11shyDichloroethane 11-Dichloroethene 12-Dichloroethene (total) 12-Dichloropropane 1122-Tetrachloroethane Trichloroethene Xylene Thallium and alpha-BHC

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Cancer Oral Dermal Toxicity Value Changes Since 2005

COPC New Source Tetrachloroethene CalEPA Trichloroethene CalEPA and USEPA (2 values used) 14-Dioxane IRIS Cadmium (food) IRIS (Now Unquantified - No Value Supported) 2378-TCDD (Dioxin) CalEPA and Dioxin Reassessment

N O T E The oral Cancer Slope Factors (CSFs) for 8 COPCs had previously been updated in 2005 (Tetra Tech FW Inc 2005b) relative to the values that were used in the 2002 CUG Report These were Chloroform 11-Dichloroethene 12shyDichloropropane Methyl tert-Butyl Ether Trichloroethene 14-DichIorobenzene Cadmium and Lindane USEPA Region 1 suggested the use ofthe CalEPA values for the oral CSF for both tetrachloroethene and trichloroethene The carcinogenic toxicity values for continuous lifetime exposure during adulthood were verified as appropriate for this assessment for vinyl chloride by USEPA Region 1 (USEAP December 6 2007b)

4 Application of Updated Toxicity Values for the Inhalation Pathway

Summary As noted earlier (see also Item 5 below) current USEPA Region 1 policy is to evaluate inhalation exposure and risk using the airborne exposure approach and RfC and lUR toxicity values To reflect this policy this calculation approach was implemented and the RfDj and CSFi values were removed from Tables 3 and 5 and were replaced with the available RfCs and lURs

Discussion The row pertaining to the Vinyl Chloride value associated with lifetime exposure from birth was removed from both Tables 3 and 5 as suggested by USEPA within General Comments 4 and noted within Specific Comments for Table 5 The lUR value for TCE was entered as 20E-06 (CalEPA) and not 17E-06 (as noted within Specific Comments for Table 5) because this is the most updated value Chronic versus Subchronic values were also footnoted and referenced accordingly (Note All changed values are shown in bold in Tables 3 and 5)

Non-Cancer Inhalation Toxicity Value Changes Since 2005

COPC New Source Acetone ATSDR Chlorobenzene PPRTV Chloroform ATSDR 12-DichIoroethane ATSDR trans-12-Dichloroethene PPRTV Methylene Chloride ATSDR n-Propylbenzene (Now Unquantified - No Value Supported) Tetrachloroethene ATSDR Toluene IRIS 14-Dioxane (Now Unquantified - No Value Supported) 123-Trichlorobenzene NCEA 124-Trichlorobenzene NCEA Aluminum PPRTV Barium HEAST C10-C22 Aromatics MassDEP

NOTE 124-Trichloroben2ene was used as a surrogate for 123-Trichlorobenzene with respect to assigning toxicological values based on consultation with EPA Superflind Technical Support Center

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Cancer Inhalation Toxicity Value Changes Since 2005

COPC New Source 11 -Dichloroethene (Now Unquantified - No Value Supported) Bis(2-ethylhexyl)phthalate (Now Unquantified - No Value Supported) Tetrachloroethene CalEPA Trichloroethene CalEPA and USEPA (2 values used) 14-Dioxane CalEPA Nickel IRIS 44^-DDE CalEPA Lindane (gamma-BHC) (Now Unquantified - No Value Supported) 2378-TCDD HEAST

N O T E The carcinogenic toxicity value for vinyl chloride published for continuous lifetime exposure during adulthood was used for this assessment

5 Evaluation of Inhalation Risk On the Basis of Exposure Using RfC and lUR Toxicity Values

Summary As indicated earlier current USEPA Region 1 policy (USEPA 2007b) is to evaluate inhalation exposure and risk using the airborne exposure approach and RfC and lUR toxicity values To reflect this policy this calculation approach was implemented for both non-cancer and cancer equations for the appropriate surface soil subsurface soil and groundwater exposure pathways (as illustrated in Appendix A)

Discussion The inhalation intake equations were rewritten for all receptors assumed to have inhalation intake from the surface soil subsurface soil or groundwater The appropriate exposure-based toxicity values were incorporated into these new relationships

6 Modification of the Application of Particulate Emission Factors (PEFs) and Volatilization Factors (VFs) for the Soil-to-Air Pathways

Summary The updated approach for applying either a PEF or a VF (but not both) to address the potential inhalation risk due to COPCs via the soil-to-air exposure pathways was systematically apphed The decision as to whether to utilize a PEF or a VF was based on the COPCs Henrys Law Constant and Molecular Weight A default PEF value consistent with the USEPAs Soil Screening Guidance was applied for the Trespasser and the CommercialIndustrial Worker receptors while a published PEF more suitable to dusty conditions during construction and excavation was applied for the Construction Worker and Utility Worker receptors

Discussion VFs were calculated and applied for those constituents that were detected in the soil that are identified as sufficiently volatile in the Draft Subsurface Vapor Intrusion Guidance (USEPA 2002c) Table 1 This Guidance considers a chemical to be volatile if its Henrys Law Constant is greater than or equal to 1 x 10 atm- m mole and its Molecular Weight is less than 200 gramsmole If a VF value was calculated it was used in the intake estimation even if a PEF was also available as the volatilization mechanism generally leads to greater exposure than through particulate inhalation in these cases

Table 6 presents the assessment of whether a surface or subsurface soil COPC was sufficiently volatile (requiring the application of a VF) For those COPCs that did not meet these criteria receptor-specific PEFs were applied instead For Trespassers and CommercialIndustrial Workers

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the default USEPA PEF value of 132 x 10 m kg (USEPA 2002c) was used This value replaced the Site-specific PEF that was developed for the 2002 CUG calculations The calculated PEF value from 2002 was re-evaluated and judged to reflect an airborne dust scenario that is too conservative (ie too dusty) for the anticipated exposures of these two receptors A PEF of 170 x 10 mVkg was used for the Construction and Utility Workers This value the same as was used in the development ofthe 2002 CUGs was published by the US Department of Energy to apply to construction work in an envirotmient with a heavy dust loading (ie 600 ugm^) This PEF value remains comparable to other approaches used to address exposures associated with soil excavation

7 Updating of the Lead Exposure Analysis

Summary Regional rather than national input parameters were applied in the Adult Lead Model evaluations performed for Trespassers CommercialIndustrial Workers and Construction Workers and the potential exposure of Utihty Workers to lead in soil was reassessed in light of USEPAs Intermittent Exposure Guidance

Discussion The original (2002) calculations (Foster Wheeler 2002) performed using the Adult Lead Model made use of default assumptions for two input parameters based on a relatively unspecified homogeneous exposed adult population These two parameters were the geometric mean blood lead level in women of child-bearing age in the absence ofany Site exposure to lead and the corresponding geometric standard deviation of this blood lead concentration in this group More specific subpopulation characteristics are now available for these parameters These parameters may be specified by region ofthe US and by race or ethnicity

In accordance with USEPA Region 1 direction the values for these parameters identified for a Non-Hispanic White population in the Northeast Region of the United States were adopted for the reevaluation These substitutions resulted in more stringent BAVs for lead for CommercialIndustrial Workers (see Table 7) Construction Workers (see Table 8) and Trespassers (see Table 9) As the exposure frequency for Utility Workers was assumed to be only 5 days per year (ie less than the minimum 90 days required to apply the Adult Lead Model) the USEPA guidance Assessing Intermittent or Variable Exposure at Lead Sites (USEPA 2003b) was consulted The decision tree presented in Figure 1 of that Guidance Document indicated that the lead exposure to Utility Workers could not be considered appropriately using the Adult Lead Model and that the exposure was sufficiently short and intermittent that it did not warrant further evaluation

8 Application of Updated Guidance-Based Modeling Parameters and Regulatory Standards

SummaryDiscussion Since the development of the CUGs in 2002 and their revision in 2005 USEPA and MassDEP have released new or updated guidance or regulatory standards on a variety of exposure toxicity or risk assessment aspects Two examples are the USEPAs updated RAGS Part E (Dermal Guidance) and the Wave Two revisions to the MassDEP Massachusetts Contingency Plan (MCP) Method 1 Standards and Upper Concentration Limits The new or updated guidance or standards applicable to the CUG development were checked for modified parameter values or newly recommended assumptions and approaches Any identified differences from past site-specific protocols were discussed with the USEPA Region 1 Risk Assessor and were incorporated into the updated BAV calculations when directed

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After all of these modifications and refinements were incorporated into the linked BAV calculation spreadsheets new BAVs were generated for each receptor exposure pathway and exposure medium combination It should be emphasized that the exposure parameters for the evaluated receptors were not changed from their original values and the target individual chemical risk goals also were not changed (ie a target excess lifetime cancer risk of 1x10 and a target Hazard Index for non-carcinogens of I were applied)

Appendix A presents a set of sample calculations of the BAVs for carcinogenic and non-carcinogenic health endpoints for the following cases

bull BAVs for Benzo(a)pyrene in Surface Soil to be Protective of a CoimnercialIndustrial Worker bull BAVs for Trichloroethene in Subsurface Soil to be Protective of a Construction Worker bull BAVs for Trichloroethene in Groundwater (Open Excavation andor Trench) to be Protective of a

Construction Worker

Further details on these and the remaining COPCs exposure media receptors that were addressed for this Site can be foimd in the 2002 CUG Report (specifically in Appendices F and G) Tables 10 through 12 present the recalculated BAVs for each appropriate receptor for the surface soil subsurface soil and groimdwater respectively

Table 10 presents the surface soil BAVs calculated to be protective of Trespassers CommercialIndustrial Workers Construction Workers and Utility Workers with respect to both carcinogenic and non-carcinogenic health effect endpoints The lowest (ie most stringent) BAV that is projected to be protective of all of these receptors relative to the surface soil also is identified in Table 10 for each COPC as is the receptor and health effect type associated with the most stringent BAV The most stringent BAVs were all associated with either CommercialIndustrial Workers (9 of 17 COPCs) or Construction Workers (7 of 17 COPCs) Depending on the carcinogenistic toxicity value assumed for trichloroethene the most stringent BAV is either associated with the Commercial Industrial Worker or the Construction Worker It should be noted that two sets of BAV calculations are shown in Table 10 for trichloroethene and for 2378-TCDD reflecting different assumptions about toxicity

Table 11 presents the subsurface soil BAVs calculated to be protective of Construction Workers and Utility Workers with respect to both carcinogenic and non-carcinogenic health effect endpoints The lowest (ie most stringent) BAV that is projected to be protective of both of these receptors relative to the subsurface soil also is identified in Table 11 for each COPC as is the receptor and health effect type associated with the most stringent BAV Nearly all of the most stringent BAVs were all associated with Construction Workers (23 of 24 COPCs) Only one COPC (12-dichloroethane) had a more stringent BAV for the Utility Worker scenario Again it should be noted that two sets of BAV calculations are shown in Table 11 for trichloroethene and for 2378-TCDD reflecting different assumptions about toxicity

Table 12 presents the groundwater BAVs calculated to be protective of Construction Workers (in either a deep trench or an open excavation) and Utility Workers (in a trench) with respect to both carcinogenic and non-carcinogenic health effect endpoints The lowest (ie most stringent) BAV that is projected to be protective of all of these receptorexposure situation combinations relative to the groundwater also is identified in Table 12 for each COPC as is the receptor and health effect type associated with the most stringent BAV All of the most stringent BAVs were associated with Construction Workers (23 of 23 calculated COPC values) Two COPCs (cis-l2-dichIoroethene and lead) do not have calculated BAV values due to lack of available data Again it should be noted that two sets of BAV calculations are shown in Table 11 for trichloroethene reflecting different assumptions about toxicity

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Tables 10 through 12 also present additional chemical-specific information to provide a context for the calculated BAV values relative to the specification of CUGs Tables 10 and II for the surface and subsurface soil respectively present the site-specific background concentrations for COPCs in each medium There are no site-specific background data shown for groundwater in Table 12 Where available the mean 95 percent upper confidence limit on the mean and maximum detected concentrations of that COPC from the background soil data sets are shown The practical quantitation limits (PQLs) for each COPC in each exposure medium also are shown in Tables 10 through 12 In addition Tables 10 and 11 list relevant regulatory policy criteria for 2378-TCDD (dioxin) in soil

As was described in the 2002 CUG Report recommended site-specific CUGs were developed using the calculated BAVs through the following process

Step A The lowest (most stringent) BAV was identified for each COPC for each exposure medium in consideration of both carcinogenic andor non-carcinogenic health effect endpoints relative to all ofthe identified receptor scenarios for that exposure medium

Step B If the COPC was a naturally occurring or ubiquitous chemical in the vicinity of the site then the risk-based BAV identified in Step A was compared to the applicable background concentration of that COPC in that exposure medium (if available) If the risk-based BAV value identified in Step A was lower than the applicable background value the recommended CUG value was adjusted upward from the BAV value to match that background level Otherwise the risk-based BAV value from Step A was carried forward in the CUG development process [NOTE The mean background concentration was used as the applicable background concentration for this effort (as it was in the 2002 CUG Report) A more appropriate measure to use in the specification of the CUGs for naturally occurring COPCs like arsenic and lead would be an upper percentile estimate ofthe background concentration ofthe COPC in that medium (ie not the sampled mean or the 95 percent-ile estimate ofthe mean) This upper percentile value would likely be somewhat less than the available maximum detected background level shown]

Step C The recommended CUG value identified in Step B was then compared to the PQL for that COPC in that exposure medium Ifthe recommended CUG value identified in Step B was lower than the PQL the recommended CUG value was adjusted upward to match the PQL Otherwise the recommended CUG value from Step B was carried forward in the CUG specification process

Step D At this point certain policy criteria established for a COPC in a similar exposure setting were adopted as the recoimnended CUG value if directed by USEPA Region 1 This step only came into play for 2378-TCDD in soil Otherwise the recommended CUG value from Step C was carried forward in the CUG specification process

Step E The recommended CUG values identified in Step D for each soil COPC were then compared to their Massachusetts Contingency Plan (MCP) Upper Concentration Limits (UCLs) for soil in Tables 10 and 11 Due to the potential for groundwater at the site to discharge into nearby River Meadow Brook the recommended CUG values identified in Step D for each groundwater COPC were compared to their respective MCP groundwater UCLs and also to their respective MCP Method 1 GW-3 standards Table 12 presents the results of these comparisons The lowest value from either Step D or Step E was shown in Tables 10 through 12 as the Recommended Site-Specific CUG for that COPC

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The CUGs presented in the ESD Report (USEPA September 2003) also are shown in Tables 10 through 12 for purposes of comparison Since 2003 Table 10 shows that the Recommended Site-Specific CUG values increased for 4 COPCs decreased for 2 COPCs and did not change for 10 COPCs One new COPC 14-dioxane now has a recommended surface soil CUG Table 11 shows that the Recommended Site-Specific CUG values increased for 21 COPCs decreased for I COPC and did not change for I COPC Once again there is a newly developed Recommended Site-Specfic CUG for 14-dioxane in the subsurface soil Table 12 shows that the Recommended Site-Specific groundwater CUG values increased for 13 COPCs decreased for 7 COPC and did not change for 4 COPCs Again a new CUG was calculated for 14-dioxane in groundwater

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REFERENCES

Foster Wheeler 2001 Draft Additional Site Investigation and Revision of Site Clean-up Goals Silresim Superfund Site Lowell Massachusetts May

Foster Wheeler 2002 Final Additional Site Investigation and Revision of Site Clean-up Goals Sibesim Superfund Site Lowell Massachusetts January

Foster Wheeler 2003 Recommended Clean-Up Goals for the Silresim Superfund Site based on Discussions during the Sih-esim Site Meeting September

Tetra Tech FW Inc 2004 Risk Evaluation for the Ufility Worker on Lowell Iron amp Steel Property Assuming Worst-Case Contamination Conditions September 31

Tetra Tech FW Inc 2005a Draft Update ofthe Sikesim Superfiind Site Clean Up Goals (CUGs) June

Tetra Tech FW Inc 2005b Draft Update of the Silresim Superftmd Site Clean Up Goals (CUGs) November

Tetra Tech FW Inc 2006 2006 MCP Amendment Impacts and Comparison of EPAMassDEP Exposure Factors - Silresim Superfund Site April

USEPA 1996 Soil Screening Guidance Users Guide USEPA Office of Solid Waste and Emergency Response Publication 93554-23 EPA540R-960I8 July

USEPA 2002a Blood Lead Concentrations of US Adult Females Summary Statistics from Phases 1 and 2 ofthe National Health and Nutrition Evaluation Survey (NHANES III) OSWER 92857shy52 March

USEPA 2002b Draft Guidance for Evaluating the Vapor Intrusion to Indoor Air Pathway from Groundwater and Soils (Subsurface Vapor Intrusion Guidance) Federal Register November 29 2002 Volume 67 Number 230 Page 71169-71172

USEPA 2002c Draft Guidance for Evaluating the Vapor Intrusion to Indoor Air Pathway from Groundwater and Soils (Subsurface Vapor Intrusion Guidance) USEPA Office of Solid Waste and Emergency Response EPA 530-F-02-052 November

USEPA 2002d Supplemental Guidance for Developing Soil Screening Levels for Superfund Sites (1996 Soil Screening Guidance Revision) USEPA Office of Solid Waste and Emergency Response OSWER 93554-24 December

USEPA 2003a Explanation of Significant Differences for the Silresim Chemical Corporation Superfiind Site Lowell MA USEPA Region I - New England Boston MA September

USEPA 2003b Assessing Intermittent or Variable Exposures at Lead Sites USEPA Office of Solid Waste and Emergency Response EPA-540-R-03-008 OSWER 92857-76 November

USEPA 2007a Memorandum from Jim DiLorenzo USEPA Region 1 RPM to Site File through Bob Cianciarulo USEPA Region 1 Chief of MA Superftmd Section and Dan Keefe USEPA Region I RPM Assessment of the Vapor Intrusion Pathway and Related Inspection of BampL Used Auto Parts - Silresim Superfund Site Lowell MA December 3

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USEPA 2007b Memorandum from Chau Vu USEPA Region 1 Human Health Risk Assessor to Dan Keefe USEPA Region I RPM Comments on the Draft 2007 Supplemental Clean-Up Goal Evaluation for the Silresim Superfund Site (dated October 31 2007) December 6

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TABLES

TABLE 1 CHRONOLOGY OF SILRESIM SITE RISK ASSESSMENTMANAGEMENT ACTIVITIES

DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001

TITLE Emergency Response Remedial Action Emergency Response Remedial Action Emergency Response Remedial Action Emergency Response Remedial Action

Final Draft Remedial Investigation Report for the Silresim Superfund Site Lowell Massachusetts shyVolume I Chapter 700 Public Health Risk and Environmental Assessment

Record of Decision

ROD Remedy Review for the Silresim Superfund Site

Draft Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superfund Site

MADE Comments on the Draft Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superftmd Site

DESCRIPTION Fenced the Site perimeter and removed approximately 30000 drums and tanks containing waste Demolished on-site buildings aboveground tanks and capped the Site Crushed stone was placed over surficial soil contamination in three areas adjacent to the Site Extended the Site perimeter fencing in the southeastern comer to enclose an area of surficial soil contamination and placed cmshed stone over surficial soil contamination in other areas Baseline risk assessment Human health receptors considered were Residents Trespassers Commercial Workers Utility (sewer) Workers and BampM Railroad Workers Ecological receptors considered were River Meadow Brook East Pond and the BampM Railroad Area The results led to a focus on indoor air quality in the buildings on the Lowell Iron amp Steel Property

Record of Decision signed for the Silresim Superftmd Site In most cases the groundwater clean-up goals linked directly or indirectly to achieving drinking water standards Evaluation ofthe remedial actions taken at the Site since the 1991 Record of Decision Review highlighted issues and changes associated with groundwater use and groundwater value determination (as a non-drinking water supply) leaching potential activity and use limitations linked to land reuse refinements in vapor migration modeling updated extent of contamination (soil and groundwater) a new chemical of concern screening process updated toxicity values and updated risk assessment policies and procedures Implemented the findings ofthe 5-Year ROD Remedy Review Evaluated a CommercialIndustrial Worker (exposure to surface soil subsurface soil groundwater) Construction Worker (exposure to surface soil subsurface soil groimdwater) BampM Railroad Worker (exposure to surface soil) and Adolescent Trespasser (exposure to surface soil) Calculated risk-based clean-up goals for target risk levels of 1 x 10 and 01 No Utility Worker addressed in this analysis based on earlier EPAMADEP Site Manager discussions with representatives ofthe municipal utility

Reference to an USEPA and MADEP meeting on May 23 with a party who had shown interest in developing the Silresim property for recreational use Potential for recreational reuse considered to exist MADEP requested that USEPA revise the risk assessment to address this potential use Recreational Child receptor selected because of anticipated greater exposure than for a Recreational Adult receptor (Note Recreational land use clean-up levels were not included in the selection ofthe ultimate clean-up goals)

2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004

November 30 2004 June 29 and November 5 2005

TITLE USEPA Comments on the Draft Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superfiind Site Draft Results for the Surface Soil Benchmark Assessment Value Development for Recreational Land Use

Draft Final Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superfund Site USEPA Comments on the Draft Final Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superfund Site Final Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superftmd Site Memorandum on Summary of Teleconference Call on the Off-Silresim Non-VOC Soil Excavation Estimates and a Proposal to Refine the Excavation Boundaries and Quantities Using a Projected Residual Risk Calculation Approach Risk Calculation Tasks to Support the ROD Amendment (as discussed at the Project Meeting of 514shy152003)

Explanation of Significant Differences for the Silresim Chemical Corporation Superftmd Site Indoor Air Vapor Intmsion Assessment

Scope of Work

Draft Update ofthe Silresim Superfiand Site Clean-Up Goals

DESCRIPTION Included MADEP comments MADEP questioned why no risk-based clean-up goals were calculated for the Sewer Workers Potential redevelopment ofthe property for an energy facility was noted Clean-up goals were developed for surface soil assuming a child recreational receptor modeled after a possible fiiture user of an athletic field (Results incorporated into the revised Additional Site Investigation and Revision of Clean-up Goals for the Silresim Superftmd Site Report Incorporated the previously identified updates revisions

Included MADEP comments Minor comments to clarify aspects of the groundwater-to-surface water connection and the vapor intrasion modeling performed

Incorporated the previously identified updates revisions

Discussion of a risk-based approach for reducing the required excavation footprint

Various alternatives were to be explored (1) changing the risk-based clean-up goals to 1x10 and 10 (2) seeing what effect Activity and Use Limitations relative to excavation and the Constmction Worker would have on the ultimate clean-up goals and (3) seeing what effect Activity and Use Limitations relative to indoor air vapor intrasion and fhe CommercialIndustrial Worker would have on the ultimate clean-up goals Incorporated revised clean-up goals reflecting groundwater reclassification updated calculations and receptors (Note Recreational land use clean-up levels were not included in the selection ofthe clean-up goals) Summary exposure and risk evaluation using the results of the indoor air sampling performed in relation to the Lowell Iron amp Steel Buildings on July 21 1999 April 26 2000 April 20 2001 and April 17 2002 Update the clean-up goals using recently revised toxicity 1 values and EPA Region 1 policies Update ofthe revised clean-up goals to also consider the 1 exposure to a Utility Worker and Adult Recreational User updated toxicity values and reassessment ofthe factors in going from risk-based Baseline assessment values to cleanshyup goals

2008-O-JV03-0008

1


DATE December 3 2007

February 19 2008

TITLE Assessment ofthe Vapor Intmsion Pathway and Related Inspection of BampL Used Auto Parts - Silresim Superftmd Site Lowell MA

Supplemental Clean-Up Goal Evaluation

DESCRIPTION Documentation of an inspection ofthe BampL Used Auto Parts property Summary ofthe indoor airvapor intmsion assessments performed relative to the Silresim Site during the period 1999 to 2003 Concluded that current conditions did not warrant a ftill assessment of potential vapor intrasion at this facility Updated and revised the prior draft benchmark assessment values (BAVs) and clean-up goals to reflect current toxicity values removing the Railroad Worker as a target receptor adding 14-dioxane removing the vapor phase inhalation pathway updated lead modeling applying the inhalation exposure assessment approach other current risk assessment guidance and current regulatory criteria

2008-O-JV03-0008

TABLE 2 NON-CANCER TOXICITY DATA - ORALDERMAL

SILRESIM SUPERFUND SITE LOWELL MASSACHUSETTS

- shyChemical Chronic Oral RfD Oral RfD Oral to Dermal Adjusted Units

of Potential Subchronic Value Units Adjustment Factor (1) Dermal

Concern RfD (2)

Acetone Chronic 900E-01 MGKG-DAY 100 900E-01 MGKG-DAY

Benzene Chronic 400E-03 MGKG-DAY 100 400E-03 MGKG-DAY

2-Bulanone Chronic 600E-01 MGKG-DAY 100 600E-01 MGKG-DAY

Chlorobenzene Subchronic (19) 700E-02 MGKG-DAY 100 700E-02 MGKG-DAY

Chloroethane NA NA NA NA NA NA

Chloroform Chronic 100E-02 MGKG-DAY 100 1OOE-02 MGKG-DAY

11-Dichloroethane Chronic 200E-01 MGKG-DAY 100 200E-01 MGKG-DAY

12-Dichloroethane NA NA NA NA NA NA

11-Dichloroethene Chronic 500E-02 MGKG-DAY 100 500E-02 MGKG-DAY

12-Dichloroethene (total) Chronic 100E-02 MGKG-DAY 100 1OOE-02 MGKG-DAY

cis-12-Dichloroethene Chronic 100E-02 MGKG-DAY 100 1OOE-02 MGKG-DAY

trans-12-Dichloroethene Chronic 200E-02 MGKG-DAY 100 200E-02 MGKG-DAY

12-Dichloropropane Chronic 900E-02 MGKG-DAY 100 900E-02 MGKG-DAY

Ethylbenzene Chronic 1 OOE-01 MGKG-DAY 100 1OOE-01 MGKG-DAY

Hexachlorobutadiene Chronic 200E-04 MGKG-DAY 100 200E-04 MGKG-DAY

Isopropylbenzene Chronic 1OOE-01 MGKG-DAY 100 1OOE-01 MGKG-DAY

4-lsopropyltoluene Chronic 1OOE-01 MGKG-DAY 100 1OOE-01 MGKG-DAY

êthylene Chloride Chronic 600E-02 MGKG-DAY 100 600E-02 MGKG-DAY

4-Methyl-2-Pentanone (MIBK) Chronic 800E-02 MGKG-DAY 100 800E-02 MGKG-DAY

êthyl-tert-butyl ether NA NA NA NA NA NA

n-Propylbenzene NA NA NA NA NA NA

Styrene Chronic 200E-01 MGKG-DAY 100 200E-01 MGKG-DAY

1122-Tetrachloroethane Chronic 400E-02 MGKG-DAY 100 400E-02 MGKG-DAY

Tetrachloroethene Chronic 1 OOE-02 MGKG-DAY 100 1OOE-02 MGKG-DAY

Toluene Chronic 800E-02 MGKG-DAY 100 800E-02 MGKG-DAY

111 -Trichloroethane Chronic 200E+00 MGKG-DAY 100 200E+00 MGKG-DAY

112-Trichloroethane Chronic 400E03 MGKG-DAY 100 400E03 MGKG-DAY

Trichloroethene Chronic 300E-04 MKG-DAY 100 300E-04 MGKG-DAY

124-Trimethylbenzene Chronic 500E-02 MGKG-DAY 100 500E-02 MGKG-DAY


Vinyl Chloride Chronic 300E-03 MGKG-DAY 100 300E-03 MGKG-DAY

Xylene (total) Chronic 200E-01 MGKG-DAY 100 200E-01 MGKG-DAY

Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver

Liver Kidney and Whole Body

NA

NA

Red blood cells and Liver

Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined

UncertaintyModifying

Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807

2008-O-JV03-0008 Page 1 of 8 Tables 5amp6 07xlsTable51



1 Chronic Oral RfD Oral RfD Oral to Dermal Adjusted Units Primary Combined Sources of RfD Dates of RfD

Chemical Subchronic Value Units Adjustment Factor (1) Dermal Target UncertaintyModifying Target Organ Target Organ (3)

of Potential RfD (2) Organ Factors (MMDDYY)

Concern

Acenaphthylene Chronic 200E-02 MGKG-DAY 100 200E-02 MGKG-DAY Body weight 3000 IRIS (5) 091807

Benzo(a)anthracene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

Benzo(a)pyrene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

Benzo(b)fluoranthene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

3enzo(ghi)perylene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

3enzo(k)fluoranthene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

Bis(2-ethyihexyl)phthalate Chronic 200E-02 MGKG-DAY 100 200E-02 MGKG-DAY Liver 1000 IRIS 091807

Chrysene Chronic 300E-02 MGKG-DAY 100 300E-O2 MGKG-DAY Kidney 3000 IRIS (6) 091807

3ibenz(ah)anthracene Chronic 300E-02 MGKG-DAY 100 300E-O2 MGKG-DAY Kidney 3000 IRIS (6) 091807

Dibenzofuran NA NA NA NA NA NA NA NA NA NA

12-Dichlorobenzene Chronic 900E-02 MGKG-DAY 100 900E-02 MGKG-DAY None 1000 IRIS 091807

13-Dichlorobenzene NA NA NA NA NA NA NA NA NA NA

14-Dichlorobenzene NA NA NA NA NA NA NA NA NA NA 1 14-Oloxane NA NA NA NA NA NA NA NA NA NA

Hexachlorobenzene Chronic 800E-04 MGKG-DAY 100 800E-04 MGKG-DAY Liver 100 IRIS 091807

lndeno(123-cd)pyrene Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY Kidney 3000 IRIS (6) 091807

Isophorone Chronic 200E-01 MGKG-DAY 100 200E-01 MGKG-DAY Kidney 1000 IRIS 091807

2-Methylnaphthalene Chronic 200E-02 MGKG-DAY 100 200E-02 MGKG-DAY Body weight 3000 IRIS (5) 091807 1

4-Methylphenol NA NA NA NA NA NA NA NA NA NA

^Japhthalene Chronic 200E-02 MGKG-DAY 100 200E-O2 MGKG-DAY Body weight 3000 IRIS 091807

Phenanthrene Chronic 300E-01 MGKG-DAY 100 300E-01 MGKG-DAY None 3000 IRIS (7) 091807

Phenol Chronic 300E-01 MGKG-DAY 100 300E-01 MGKG-DAY Body weight 300 IRIS 091807

Pyridine Chronic 100E-03 MGKG-DAY 100 1 OOE-03 MGKG-DAY Liver 1000 IRIS 091807

123-Trichlorobenzene Chronic 1OOE-02 MGKG-DAY 100 1OOE-02 MGKG-DAY Kidney 1000 IRIS (10) 091807

124-Trichlorobenzene Chronic 1OOE-02 MGKG-DAY 100 1OOE-02 MGKG-DAY Kidney 1000 IRIS 091807


TABLE 2 NON-CANCER TOXICITY DATA ~ ORALDERMAL


Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium

Beryllium Cadmium (food)

Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane

4^ -DDE Endosulfan sulfate

-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Oral to Dermal Adjustment Factor (1)

100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ

Neurotoxicity Developmental

Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS

Autoimmune OrganBody weight

Selenosis

None NA

Eye Keratin Immune System




Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA

Dates of RfD Target Organ (3)

(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


TABLE 2 NON-CANCER TOXICITY DATA - ORAUDERMAL


Chemical Chronic Oral RfD Oral RfD Oral to Dermal Adjusted Units Primary Combined Sources of RfD Dates of RfD

of Potential Subchronic Value Units Adjustment Factor (1) Dermal Target UncertaintyModifying Target Organ Target Organ (3)

Concern RfD (2) Organ Factors (MMDDYY)

C I O - C 2 2 Aromatics Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-DAY NA NA MassDEP (15) 10312002

C19 -C3 6 Aliphatics Chronic 200E+00 MGKG-DAY 100 600E+00 MGKG-DAY NA NA MassDEP (15) 10312002

C5 - C8 Aliphatics Chronic 400E-02 MGKG-DAY 100 600E-02 MGKG-DAY NA NA MassDEP (15) 10312002

C 9 - C I O Aromatics Chronic 300E-02 MGKG-DAY 100 300E-02 MGKG-OAY NA NA MassDEP (15) 10312002

C 9 - C I 2 Aliphatics Chronic 1OOE-01 MGKG-DAY 100 600E-01 MGKG-DAY NA NA MassDEP (15) 10312002


NOTES BOLDED ENTRIES INDICATE A CHANGE SINCE THE NOVEMBER 2005 REVISION NA = Not Available signifies inadequate or unassessed inhalation data IRIS = Integrated Risk Infonnation System ATSDR = Agency for Toxic Substances and Disease Registry Minimal Risk Levels CalEPA = California Environmental Protection Agency Office of Environmental Health and Hazard Assessment Toxicity Criteria Database HEAST= Health Effects Assessment Summary Tables MassDEP= Massachusetts Department of Environmental Protection PPRTV = Provisional Peer Reviewed Toxicity Value USEPA = US Environmental Protection Agency (I) Refer to RAGS Part E Exhibit 41 (USEPA 2001)

^ laquo y D bdquo [ ^ ^ _ j J = laquo D o [ ^ ^ ^ J OraloDerbdquoAdjbdquosnebdquoFbdquoaor

(3) For IRIS values this is the date IRIS was searched For ATSDR values this is the date of MRL For CalEPA values this is the date CalEPA was searched For HEAST values this is the date of HEAST For PPRTV values this is the date of the provisional value was confirmed

(4) Isopropylbenzene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (5) Naphthalene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (6) Pyrene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (7) Anthracene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (8) Hexavalent Chromium toxicological information used (9) Mercuric chloride toxicological information used (10) 124-Trichlorobenzene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center ( I I ) Aroclor 1254 toxicological information used based on consultation with EPA Superfund Technical Support Center (12) Values obtained from EPA Superfund Technical Support Center (13) cis-12-Dichloroethene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (14) Endosulfan toxicological information used based on consultation with EPA Superfund Technical Support Center (15) MADEP 2002 Characterizing Risks Posed by Petroleum Contaminated Sites Implementation of MADEP VPHEPH Approach October 31 (16) Thallium(l)Sulfate used as a surrogate as per USEPA Risk Assessor (17) For trichloroethene the oral RfD value is from the EPAs Trichloroethylene Health Risk Assessment Synthesis and Characterization (External Review Draft) 2001 (18) For vinyl chloride the oral RfD value is the subchronic value for an adult

2008-O-JV03-0008 Page 4 of 8 Tables 5amp6_07xlsTable51

TABLE 3 NON-CANCER TOXICITY DATA - INHALATION


Chemical Value Primary Combined Sources of Dates of RfC of Potential Inhalation Target UncertaintyModifying RfCiRfD and RfD

Concern RfC(1) Organ Factors Target Organ Target Organ (2) (ugm3) (MMDDYY)

Acetona 130E04 CNS 100 ATSDR 122107 3enzene 300E-01 White BloocJ Cells 300 IRIS 121707 2-Butanone 500E+03 Developmental 300 IRIS 121707 Chlorobenzene SOOE-t-lll Liver Kidney 1000 PPRTV 91707

Chloroethane 100E04 Fetus Bones 300 IRIS 121707

Chloroform 992E+01 Liver 100 ATSDR 122107

11-Dichloroethane 500E-02 Kidney 1000 HEAST 073197

12Dichloroethlaquone 247E1-03 Liver 90 ATSDR 122107

11-Dichloroethene 2 OOE-02 Liver 30 IRIS 121707

12-Oichloroethene (total) NA NA NA NA NA

as-12-Dichloroethene NA NA NA NA NA

trangt-12-Dlchloroethene 600Elaquo01 Lungs 3000 PPRTV 091707

12-Dichloropropane 400E+00 Nose 300 IRIS 121707

ithylbenzene 1 OOE-03 Developmental 300 IRIS 121707

-texachlorobutadiene NA NA NA NA NA

sopropyltwnzene 400E02 Kklney 1000 IRIS 121707

4-lsopropyltoiuene 400E-02 Kidney 1000 IRIS (3) 121707

Methylene Chloride 106E-03 Liver 30 ATSDR 122107

4-Melhyl-2-Pentanone (MIBK) 3 00E03 Fetus 300 IRIS 121707

êthyl-tert-butyl ether 300E-03 Liver Kidney 100 IRIS 121707

1-Propylbenzene NA NA NA NA NA

Styrene 1OOE-03 CNS 30 IRIS 121707

1122-Totrachloroethane NA NA NA NA NA

Tetrachloroethene 2 76E-02 CNS 100 ATSDR 12212007

Toluene S O O E - F O J CNS 10 IRIS 121707

111-Trichloroethane 220E-03 Neurotoxicity NA PPRTV 051205

112-Trichloroethane NA NA NA NA NA

Trichloroethene 400E-01 NA NA USEPA (45) 051205

124-Trimethyltraquon2ene 600E-00 NA NA USEPA (4) 051205

135-Triniethylbenzene 600E-00 NA NA USEPA (4) 051205

Vinyl ChioricJe 1OOE-02 Liver 30 IRIS 121707

jxylene (total) 1OOE-02 Motor Coordination 300 IRIS 121707

Acenaphthylene 300E-00 Nose 3000 IRIS (6) 121707

3enzo(a)anthracene NA NA NA NA NA

3enzo(a)pyrene NA NA NA NA NA

3enzo(b)f1uoranthene NA NA NA NA NA

3enzo(ghi)perylene NA NA NA NA NA

Jenzo(k)fluoranthene NA NA NA NA NA 1 3is(2-ethylhexyl)phthalate NA NA NA NA NA

Chrysene NA NA NA NA NA

Dibenz(ah)anthracene NA NA NA NA NA

Dibenzofuran NA NA NA NA NA

200e-OOV03-0008 TablB3-12-24-07xlsTablB3



Chemical Value Primary Combined Sources of Dates of RfC of Potential Inhalation Target UncertaintyTôdifying RfCiFtfD and RfD

Concern RfC(1) Organ Factors Target Organ Target Organ (2) (ugfmS) (MMDOYY)

Whole Body - Decreased 12-Otchlorobenzene 200E-02 1000 HEAST 073197

Weight Gain

13-Dichlorobenzene NA NA NA NA NA 14-Dichlorobenzene 800E-02 Liver 100 IRIS 121707 14-Dloxane NA NA NA NA NA Hexachlorobenzene NA NA NA NA NA indeno(123-cd)pyrene NA NA NA NA NA sophorone NA NA NA NA NA 2-Methylnaphthalene 300E-00 Nose 3000 IRIS (6) 121707 4-Methylphenol NA NA NA NA NA Maphthalene 300E-00 Nose 3000 IRIS 121707 Phenanthrene NA NA NA NA NA Phenol NA NA NA NA NA Pyridine NA NA NA NA NA

123-Trichlorobenzena 4 OOE-00 Liver 1000 NCEA 100107

124-Trichlorobenzane 400E-00 Liver 1000 NCEA 100107

Aluminum 500E-00 Psychomotor 300 PPRTV 9172007 Antiriiony NA NA NA NA NA Arsenic NA NA NA NA NA Barium 500E-01 Fetus 1000 HEAST 12C107 Beryllium 2 OOE-02 Lung 10 IRIS 121707 Cadmium (food) NA NA NA NA NA Cadmium (water) NA NA NA NA NA Chromium (total) 1OOE-01 Lung 300 IRIS (7) 121707 Copper NA NA NA NA NA Lead NA NA NA NA NA Manganese 500E-02 CNS 1000 IRIS 121707 Mercury 300E-01 CNS 30 IRIS (8) 121707 Nickel 900E-02 Respiratory 30 ATSDR 090303 Selenium NA NA NA NA NA Thallium NA NA NA NA NA Vanadium NA NA NA NA NA

Arockir-1242 NA NA NA NA NA Arodor-1248 NA NA NA NA NA Aroclor-1254 NA NA NA NA tMA

Arockgtr-1260 NA NA NA NA NA

Aldrin NA NA NA NA NA alpha-BHC NA NA NA NA NA Deta-BHC NA NA NA NA NA

aelta-BHC NA NA NA NA NA 3htordane 700E-01 Liver 1000 IRIS 121707 4-4--DDE NA NA NA NA NA Endosulfan sulfate NA NA NA NA NA -leptachlor NA NA NA NA NA ieptachlor Epoxkte NA NA NA NA tltA

Jndane (gamma-BHC) NA NA NA NA NA

2378-TCDD NA NA NA NA NA

C10 - C22 Aromatics SOOE-rOI NA NA MassDEP (9) 103102 C19-C36 Aliphatics NA NA NA NA tÂ 5 - C8 Aliphatics NA NA NA NA NA

9 - C I O Aromatics NA NA NA NA NA

9 - C 1 2 Aliphatics NA NA NA NA NA

3 9 - C I 8 Aliphatics NA NA NA NA NA

NOTES BOLDED ENTRIES INDICATE A CHANGE SINCE THE NOVEMBER 2005 REVISION NA = Not Available signifies inadequate or unassessed inhalation data IRIS = Integrated Risk Information Systefn ATSDR = Agency for Toxic Substances and Disease Registry Minimal Risk Levels CalEPA = California Environmental Protection Agency Office of Environmental Healtti and Hazand Assessment Toxicity Critena Database HEAST= Health Effects Assessment Summary Tables MassOEP= Massachusetts Department of Environmental Pnatectkin NCEA = Nabonal Center for Environmental Technical Support Center PPRTV = Provisional Peer Reviewed Toxicity Value USEPA = US Environmental Pnatection Agency (1) All listed values relate to chronic exposure (2) For IRIS values this is the date IRIS was searched

For ATSDR values this is the date of MRL For CalEPA values this is the date CalEPA was searched For HEAST values this is the date of HEAST For NCEA values this ts the date of the article provkJed by NCEA For PPRTV values this is the date of the provisional value was confirmed

(3) Isopropyltjenzene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (4) Values obtained from EPA Superfurnj Technical Support Center (5) For trichloroethene the inhialation RfC value is from the EPAs Trichloroethylene Health Risk Assessment Synthesis and Ctiaracterizatkin (External Review Draft) 2001

(6) Napthtalene was used as a sunogate for toxicological values (7) Hexavalent chromium toxicological information used (6) Elemental nêrcury toxicological values were used (9) MADEP 2002 Characterizing Risks Posed by Petroleum Contaminated Sites Implemenlatkin of MADEP VPHEPH Approach October 31

200e-O-JV03-0008 Page 2 of 2 Table3-12-24-07xlsnable3

TABLE 4 CANCER TOXICITY DATA - OFiAUDERMAL


Chemical Oral Cancer Slope Factor Oral 10 Dermal Adjusted Dermal Source Date of Slope

of Potential Adjustment Cancer Slope Factor (1) Units Cancer Guideline Target Organ Factor (2)

Concern Factor Description (MMDDYY)

Acetone NA NA NA NA NA NA NA

Benzene 550E-02 100 550E-02 (MGKG-DAY)-1 A IRIS 091807

2-Butanone NA NA NA NA NA NA NA

Chlorobenzene NA NA NA NA D IRIS 091807

Chloroethane NA NA NA NA NA NA NA

Chloroform 1OOE-02 100 1 OOE-02 (MGKG-DAY)-1 B2 IRIS 091807

11-Dichloroethane NA NA NA NA C IRIS 091807

12-Dichloroethane 910E-02 100 9 iaE -02 (MGKG-DAY)-1 B2 IRIS 091807

11-Dichloroethene NA NA NA NA C IRIS 091807

12-Dichloroethene (total) NA NA NA NA D IRIS (3) 091807

cis-12-Dichloroethene NA NA NA NA D IRIS 091807

trans-12-Dichloroethene NA NA NA NA NA NA NA

12-Dichloropropane 360E-02 100 360E-02 (MGKG-DAY)-1 NA CalEPA 091907

Ethylbenzene NA NA NA NA D IRIS 091807

Hexachlorobutadiene 780E-02 100 780E-02 (MGKG-DAY)-1 C IRIS 091807

Isopropylbenzene NA NA NA NA D IRIS 091807

4-lsopropyltoluene NA NA NA NA D IRIS (4) 091807

Methylene Chloride 750E-03 100 750E-03 (MGKG-DAY)-1 B2 IRIS 091807

4-Methyl-2-Pentanone (MIBK) NA NA NA NA NA NA NA

Methyl-tert-butyl ether 180E-03 100 180E-03 (MGKG-DAY)-1 NA CalEPA 091907

n-Propylbenzene NA NA NA NA NA NA NA

Styrene NA NA NA NA NA NA NA

1122-Tetrachloroethane 200E-01 100 200E-01 (MGKG-DAY)-1 C IRIS 051305

Tetrachloroethene 540EO1 100 540E-01 (MGKG-DAY)-1 NA CalEPA 122107

Toluene NA NA NA NA NA NA NA

111-Trichloroethane NA NA NA NA D IRIS 3112005

112-Trichloroethane 570E-02 100 570E-02 (MGKG-DAY)-1 C IRIS 031105

Trichloroethene 130E42 100 130E02 (MGKG-DAY)-1 NA CalEPA (11) 122107

124-Trimethylbenzene NA NA NA NA NA NA NA


Vinyl Chloride 720E-01 100 720E-01 (MGKG-DAY)-1 A IRIS (5) 091807

Xylene (total) NA NA NA NA NA NA NA


TABLE 4 CANCER TOXICITY DATA - ORALDERMAL


Chemical Oral Cancer Slope Factor Oral to Dermal Adjusted Dermal Source Date of Slope



Acenaphthylene NA NA NA NA D IRIS 091807

3enzo(a)anthracene 730E-01 100 730E-01 (MGKG-DAY)-1 B2 IRIS (6) 091807

Benzo(a)pyrene 730E+00 100 730E+00 (MGKG-DAY)-1 B2 IRIS 091807

Benzo(b)fluoranthene 730E-01 100 730E-01 (MGKG-DAY)-1 B2 IRIS (6) 091807

Benzo(ghi)perylene NA NA NA NA IRIS 091807

Benzo(k)fluoranthene 730E-02 100 730E-02 (MGKG-DAY)-1 82 IRTS(6) 091807

Bis(2-ethylhexyl)phthalate 140E-02 100 140E-02 (MGKG-DAY)-1 B2 IRIS 091807

Chrysene 730E-03 100 730E-03 (MGKG-DAY)-1 82 IRIS (6) 091807

Dibenz(ah)anthracene 730E+00 100 730E+00 (MGKG-DAY)-1 82 IRIS (6) 091807

Dibenzofuran NA N7A NA NA D IRIS 091807

12-Dichlorobenzene NA NA NA NA D IRIS 091807


14-Dichlorobenzene 540E-03 100 540E-O3 (MGKG-DAY)-1 NA CalEPA 091907

14-Dioxane 110E-02 100 110E-02 (MGKG-DAY)-1 B2 IRIS 091807

Hexachlorobenzene 160E+00 100 160E+00 (MGKG-DAY)-1 B2 IRIS 091807

lndeno(123-cd)pyrene 730E-01 100 730E-01 (MGKG-DAY)-1 82 IRIS (6) 091807

Isophorone 950E-04 100 950E-04 (MGKG-DAY)-1 C IRIS 091807

2Methylnaphthalene NA NA NA NA NA NA NA

4-Methylphenol NA NA NA NA C IRIS 091807

Naphthalene NA NA NA NA C IRIS 091807

Phenanthrene NA NA NA NA D IRIS 091807

Phenol NA NA NA NA D IRIS 091807

[pyridine NA NA NA NA NA NA NA

123-Trichlorobenzene NA NA NA NA D IRIS (7) 091807

124-Trichlorobenzene NA NA N T A NA D IRIS 091807

Aluminum NA NA NA NA NA NA NA

Antimony NA NA NA NA NA NA NA

Arsenic 150E+00 100 150E+00 (MGKG-DAY)-1 A IRIS 091807

Barium NA NA NA NA D IRIS 091807

Beryllium NA NA NA NA B1 IRIS 091807

Cadmium (food) NA NA NA TA B1 IRIS 091807

Cadmium (water) NA NA NA NA B1 IRIS 091807

Chromium (total) NA NA NA NA A IRIS 091807

Copper NA NA NA NA D IRIS 091807

Lead NA IÂ NA NA 82 IRIS 091807

Manganese NA NA NA NA D IRIS 091807

Mercury NA NA NA NA C IRIS (8) 091807

Mickel NA NA NA NA NA NA NA

Selenium NA NA NA NA D IRIS 091807

Thallium NA NA NA NA D IRIS 091807

Vanadium NA NA NA NA NA NA NA 1

2008-O-JV03-0008 Page 6 of 8 Tables 5amp6 07 xlsTabie61



Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD

C I O - C 2 2 Aromatics

C19-C36 Aliphatics

C5 - C8 Aliphatics

C 9 - C I O Aromatics

C 9 - C I 2 Aliphatics


Oral Cancer Slope Factor

200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal

Cancer Slope Factor (1)

200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA

Dioxin Reassessment (10)

NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA

2008-O-JV03-00O8 Page 7 of 8 Tables 5amp6 07xlsTable61

TABLE 4 CANCER TOXICITY DATA ~ ORAUDERMAL


Chemical Oral Cancer Slope Factor Oral to Dermal Adjusted Dermal Source Date of Slope of Potential Adjustment Cancer Slope Factor (1) Units Cancer Guideline Target Organ Factor (2)


NOTES BOLDED ENTRIES INDICATE A CHANGE SINCE THE NOVEMBER 2005 REVISION NA = Not Available signifies inadequate or unassessed inhalation data IRIS = Integrated Risk Information System EPA Group ATSDR = Agency for Toxic Substances and Disease Registry Minimal Risk Levels A - Human carcinogen CalEPA = California Environmental Protection Agency Office of Environmental Health and Hazard Assessment Toxicity Criteria Database 81 - Probable human carcinogen - indicates that limited human data are available HEAST= Health Effects Assessment Summary Tables B2 - Probable human carcinogen - indicates sufficient evidence in animals and MassDEP= Massachusetts Department of Environmental Protection inadequate or no evidence in humans PPRTV = Provisional Peer Reviewed Toxicity Value C - Possible human carcinogen

D - Not classifiable as a human carcinogen (1) SFc [ V H kg - day j E - Evidence of noncarcinogenicity

SFr laquolaquo k g -day ) 1 ( j bdquo bdquo Ogrbdquo AdJuslmenI Factor

(2) For IRIS values this is the date IRIS was searched

For ATSDR values this is the date of MRL For CalEPA values this is the date CalEPA was searched For HEAST values this is the date of HEAST For PPRTV values this Is the date of the provisional value was confirmed

(3) cis-12-Dichloroethene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (4) Isopropylbenzene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (5) Value taken from the LMS method for continous lifetime exposure during adulthood (6) 8enzo(a)pyrene toxic equivalency factors applied to slope factor based on consultation with EPA Superfund Technical Support Center (7) 124-Trichlorobenzene used as a surrogate for toxicological values based on consultation with EPA Superfund Technical Support Center (8) Mercuric chloride toxicological information used (9) Value based on consultation with EPA Superfund Technical Support Center (10) Proposed value in USEPAs Draft Dioxin Reassessment 2000 (11) Tables 10 11 and 12 also calculate the BAV using the upper bound of the CSF range (40E-01 mgkg-day) from the EPAs Trichloroethylene Health Risk Assessment 2001 per request of Region 1 Risk Assessor (42108) (lisl


- laquo ^

TABLE 5

CANCER TOXICITY DATA ~ INHALATION


Chetnical Source Date of Unit of Potential Unit Risk Cancer Guideline Risk Factor (1)

Concern (ugm3)-1 Description (MMDDYY)

Acetone NA NA NA NA

Benzene 780E-06 A IRIS 121707

2-Butanone NA NA NA NA

Chlorobenzene NA NA NA NA

Chloroethane NA NA NA NA

Chloroform 230E-O5 B2 IRIS 121707

11-DichloTOethane NA NA NA NA

12-Dichloroethane 260E-05 B2 IRIS 121707

11-Oichlaroethene NA NA NA NA

ll 2-Dichloroethene (total) NA NA NA NA

cis-12-Dichloroethene NA NA NA NA

trans-12-Dichlon3ethene NA NA NA NA

12-Dichloropropane 100E-05 NA CalEPA 121707

Ethylbenzene NA NA NA NA

Hexachlorobutadiene 220E-a5 C IRIS 121707

Isopropylbenzene NA NA NA NA

4-lsopropyltoluene NA NA NA NA

Methylene Chloride 470E-07 B2 IRIS 121707

4-Methyl-2-Pentanone (MIBK) NA NA NA NA

Methyl-tert-butyl ether 260E-07 NA CalEPA 121707

n-Propylbenzene NA NA NA NA

Styrene NA NA NA NA

1122-Tetrachloroethane 580E-05 C IRIS 121707

Tetrachloroethene 590E-06 NA CalEPA 121707

Toluene NA NA NA NA

111 -Trichloroethane NA NA NA NA

112-Trichloroethane 160E-05 C IRIS 121707

Trichloroethene 200E-06 NA CalEPA (5) 121707

124-Trimethylbenzere NA NA NA NA

135-Trimethylbenzene NA NA NA NA

Vinyl Chloride 440E-06 A IRIS (2) 121707

Xylene (total) NA NA NA NA 1 Acenaphthylene NA NA NA NA 1 Ben20(a)anthracene NA NA NA NA

Benzo(a)pyrene NA NA NA NA

Benzo(b)fluoranthene NA NA NA NA

Benzo(ghi)perylene NA NA NA NA

Benzo(k)fluoranthene NA NA NA NA

Bis(2-ethyihexyl)phthaiate NA NA NA NA

Chrysene NA NA NA NA Dibenz(ah)anthracene NA NA NA NA

Dibenzofuran NA NA NA NA

12-Dichlorobenzene NA NA NA NA


14-Dichlorobenzene 110E-05 NA CalEPA 121707

14-Dioxane 770EO6 NA CalEPA 121707

Hexachlorobenzene 460E-04 B2 IRIS 121707

lndeno(123-cd)pyrene NA NA NA NA

Isophorone NA NA NA NA

2-Methylnaphthalene NA NA NA NA

4-Methylphenol NA NA NA NA

Naphthalene NA NA NA NA

Phenanthrene NA NA NA NA

Phenol NA NA NA NA

Pyridine NA NA NA NA

123-Trichlorobenzene NA NA NA NA

124-Trichlorobenzene NA NA NA NA j

2008-O-JV03-0008 Page 1 of 2 Table5-12-24-Q7xlsTable5

TABLE 5

CANCER TOXICITY DATA - INHALATION


Chemical Source Date of Unit of Potential Unit Risk Cancer Guideline Risk Factor (1)


Aluminum NA NA NA NA

Antimony NA NA NA NA

Arsenic 430E-03 A IRIS 121707

Barium NA NA NA NA

Beryllium 240E-03 B1 IRIS 121707

Cadmium (food) 18DE-03 B1 IRIS 121707

Cadmium (water) NA NA NA NA

Chromium (total) 120E-02 A IRIS (3) 121707

Copper NA NA NA NA

Lead NA NA NA NA

Manganese NA NA NA NA

Mercury NA NA NA NA

Nickel 240E-04 A IRIS 121707

Selenium NA NA NA NA

Thallium NA NA NA NA

Vanadium NA NA NA NA

Aroclor-1242 (particulates) 571 E-G4 B2 USEPA (4) 091807

Aroclor-1248 (particulates) 571 E-04 B2 USEPA (4) 091807



Aroclor-1242 (volatiles) 114E-04 B2 USEPA (4) 091807

Aroclor-1248 (volatiles) 114E-04 B2 USEPA (4) 091807 Aroclor-1254 (volatiles) 114E-04 82 USEPA (4) 091807

Aroclor-1260 (volatiles) 114E-04 B2 USEPA (4J 091807

Aldrin 490E-03 B2 IRIS 121707

alpha-BHC 180E-O3 B2 IRIS 121707

beta-BHC 530E^)4 C IRIS 121707

delta-BHC NA NA NA NA

Chlordane 100E-04 B2 IRIS 121707

44DDE 400E-05 B2 CalEPA 121707

Endosulfan sulfate NA NA NA NA

Heptachlor 13DE-03 B2 IRIS 121707

Heptachlor Epoxide 260E-03 B2 IRIS 121707

Lindane (gamma-BHC) NA NA NA NA

2378-TCDO 33E-05 B2 HEAST 122107

CIO-022 Aromatics NA NA NA NA

C19-C36 Aliphatics NA NA NA NA

C5 - C8 AliphaBcs NA NA NA NA

C9-CIO Aromatics NA NA NA NA

C9 - C12 Aliphatrcs NA NA NA NA

C9-C18Aliphatks NA NA NA NA

NOTES BOLDED ENTRIES INDICATE A CHANGE SINCE THE NOVEMBER 2005 REVISION NA = Not Available signifies inadequate or unassessed inhalation date IRIS = Integrated Risk Information Systen

CalEPA = California Environmental Protection Agency Office of Environmental Health and Hazard Assessment Toxicity Criteria Database HEAST= Health Effects Assessment Summary Tables USEPA = US Environmental Protection Agency (1) For IRIS values this is the date IRIS was searched

For ATSDR values this is the date of MRL For CalEPA values this is the date CalEPA was searched For HEAST values this is the date of HEAST For PPRTV values this is the date of the pnjvisional value was confirmed

(2) Value taken from the LMS method for continous lifetime exposure during adulthood (3) Hexavalent Chromium toxicological information used (4) Value taken from email from EPA Region 1 risk assessor with suggested toxicity values (5) Tables 10 11 and 12 also calculate the BAV using the upper bound of the CSF range (110 E-04 ugrr) from the EPAs Trichloroethylene Health Risk Assessment 2001 per request of Region 1 Risk Assessor (51407) (listed as the second row entry for TCE in Tables 10 11 and 12

2O08-O-JV03-0008 Page 2 of 2 Table5-12-24-07xlsTable5

TABLE 6

DETERMINATION OF VOLATILITY FOR APPLICATION OF A VOLATILIZATION FACTOR FOR THE SURFACE AND SUBSURFACE SOIL COCs

Sllrestm Superfund Site

1 DECISION FACTORS |

Chemical Henrys Law Henrys Law Molecular Is Henrys Law gt10E-05 Is molecular weight VF needed

of Potential Constant 11234) Constant (5) Weight (234) atm-m^mo1 lt200 g mde

Concern H H MW

unitless atm-m3mol g md

Benzene 22SE-01 556E-03 78 1 YES YES YES

Chlorobenzene 152E-01 371E03 1126 YES YES YES

Chtofotonn 150E01 366E-03 1194 YES YES YES

12-Dichk)rDethane 401E02 978E04 99 YES YES YES

11-Dichkraquooethene 107E00 261E02 969 YES YES YES

Ethyltjenzene 323EJ)1 788EJ)3 1062 YES YES YES

Methylene Chlonde 898E-02 219E^)3 8 4 9 YES YES YES

Styrene 1 13E-01 276E-03 104 1 YES YES YES

1122-TetracWoroettiane 141E-02 344E-04 1 6 7 9 YES YES YES

754E-01 184E^)2 1658 YES YES YES

Toluene 270E-O1 659E-03 921 YES YES YES

111-Trichloroethane 705E01 172E-02 1334 YES YES YES

112-Trichloroethane 374E^gt2 912E-CI4 1334 YES YES YES

Tnchloroethene 422E^)1 103E-02 1314 YES YES YES

124-Tnniethylbenzene 252E-01 615E03 120 2 YES YES YES

135-Trimethylbenzene 359E-01 876E-03 120 2 YES YES YES

^înyl chlonde 1 11E+00 2 71E-02 625 YES YES YES

Benzo(a)anthraoene 137E04 334E-06 228 3 NO NO NO

Benzolta)pyTene 463E05 113E-06 2523 NO NO NO

Benzoltb)fluoranthene 455E^)3 1 11E-04 2523 YES NO NO

Dibenzah)anlhracene 603E-07 147E-08 2784 NO NO NO

12-Dichlorobenzene 779E-02 190E-03 147 YES YES YES

14-Dioxane 196E04 478E-06 881 NO YES NO

Hexachlorobenzene 541EJJ2 132E-03 2848 YES NO NO

4aphtlialene 19eE02 483E-04 1282 YES YES YES

124-Tnchlorobenzene 580E02 141E03 1815 YES YES YES

ftreenpc 7 7 9 NO NO

Lead 207 2 NO NO -Mercury 2006 NO NO

237S-TCDD 204E-03 498E-05 3220 YES NO NO

ftrockx-1242 140E-02 341 E-04 2920 YES NO NO

Aroclor-1254 116E-02 2B3E-04 3264 YES NO NO

ftroclor-1260 137E-02 334E-04 3953 YES NO NO ftluminum Antimony

Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm

C I O - C 2 2 Aromatics 720E04 300E-02 150 YES YES YES

C 1 9 - C 3 6 Aliphatics YES NO No

C5 - c e Aliphatics 130E+00 540E-01 93 YES YES YES

C9-CIOAromat ics 792E-03 330E-01 120 YES YES YES

C 9 - C 1 2 Aliphatics 156E+00 6 50E+01 149 YES YES YES

C 9 - C I S Aliphatics 166E+00 690E+01 170 YES YES VES II

Footnotes

(1) EPA 2002 Supplemental Guidance for Developing Soil Screening Levels for Superlund Sites OSWER 93554-24 December Extiibit C-1

(2) EPA 2004 Risk Assessment Guidance for Superfund Volume I Human Health Evaluation Manual (Pari E) July Appendix 8

(3) Risk Assessment Information System (RAIS) tittpnskl5dornl govcgi-bintoxTOX_selectselect =csf Accessed September 26 2007

(4) Syracuse Research Corporation 2007 CHEUFATE Database httpwwwsyrTe3 comescefdbhtm Accessed September 26 2007

(5) EPA 1991 Henrys Law Constant (unitless) was converted to Henrys Lew Constant (atnn-mSmol) using the relationship presented in (he Superfund Exposure

Assessment Manual p 20 equation 2-13

H latm m^ mol] = H x R [atm m^ mol K] x T x K

200ampO-JV03-0008

TABLE 7 ADULT LEAD MODEL ASSUMPTIONS AND CALCULATIONS FOR THE COMMERCIAL INDUSTRIAL WORKER


Scenario Timeframe CurrentFuture Medium Soil Exposure Medium Surface Soil Exposure Point Silresim and Industrial Properties Surrounding Silresim Receptor Population CommercialIndustrial Worker Receptor Age Adult

Parameter Parameter Code Definition

BAV Calculated Risk-Based Cleanup Goal (or Lead

PbB fetal 095goal Goal for the 95th Percentile Fetal Blood Lead Concentration Among Fetuses Bonn to Women Having Exposures to the Site Soil

GSD i adult Individual Geometric Standard Deviation Blood Lead Level Among Women of Chjid-Bearing Age

R fetalmaternal Constant of Proportionality Between the Fetal Blood Lead Concentration at Birth and the Maternal Blood Lead Level

PbB adultO Typical Blood Lead Concentration in Adults (Women of Child-Bearing Age) in the Absence of Exposures to the Site Soil

BKSF Biolsinetic Slope Factor Relating Increase in Typical Adult Blood Lead Concentration to Average Daily Lead Uptake

IRs Combined Soil and Dust Intake Rate EF Exposure Frequency

AF Absolute Gastrointestinal Absorption Fraction for Ingested Lead in Soil

1 AT Averaging Time for Exposure

PbB fetal 0 95goal PbB adult central goal GSD^^y^^R felal

[PbB - PIgtBûio)-^T adub cen tral goa I BAV bull

BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days

Value Rationale Reference

808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name

Adult Lead Model (see Notes)

II

[1 ] USEPA 2003 Recommendations of the Technical Review Workgroup for Lead for an Approach to Assessing Risks Associated with Adult Exposures to Lead EPA-540-R-03-001 OSWER Directive 92857-54 value for protection of the fetus to the same level as children Recommended for estimating cleanup goals based on risk to the developing fetus

[2] USEPA 2002 Blood Lead Concenb-ations of US Adult Females Summary Statistics from Phases 1 and 2 of the National Health and Nutrition Evaluation Survey (NHANES III) Table 3a Values for Northeast Region Non-Hispanic White Subpopulatkgtn OSWER 92857-52 March 2002 [3] USEPA 2003 Table 1 - Default value based on Goyer (1990) and Graziano et al (1990)

[4] USEPA 2003 Table 1 - Default value derived from the study of Pocock et al (1983) which based the study between tap water lead concenb^tksns and blood lead concentrations in adult males and the analysis of Sherlock et al (1984)

[51 Set to soil ingestion rate listed in Table 6-19 of the Final Additional Site Investigation and Revision of Site Clean-up Goals (Foster Wheeler 2002)

[6] Regional value reflecting the amount of time soil would be covered by snow and ice Suggested value for worfters in non-contact intensive activities (USEPA 2001) (ie non-intrusive) - See USEPA Comment in Appendix A

[7] USEPA 2003 Table 1 - Default value based on an absorption factor for soluble lead of 020 and the relative bioavailability of Pb as 06 (soilsoluble)

[8] For continuing long tenn exposures Sufficient for blood lead levels to approach quasi-steady state

2008-O-JV03-0008 TD01-066 522008 Page 1 of 4 3-Tables789xlsCIW

TABLE 8 ADULT LEAD MODEL ASSUMPTIONS AND CALCULATIONS FOR THE CONSTRUCTION WORKER


Scenario Timeframe CurrentFuture Medium Soil Exposure Medium Surface Soil Exposure Point Any Industrial Property Discussed in ttie CSM Receptor Population Construction Worlter Receptor Age Adult

-Parameter Parameter Units Value Rationale Equation

Code Definition Reference Model Name

BAV PbB fetal 095goal

Calculated Risk-Based Cleanup Goal for Lead Goal for the 95th Percentile Fetal Blood Lead Concentration Among

Fetuses Bom to Women Having Exposures to the Site Soil

mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO

Individual Geometric Standard Deviation Blood Lead Level Among Women of Child-Bearing Age

Constant of Proportionality Between the Fetal Blood Lead Concentration at Birth and the Maternal Blood Lead Level

Typical Blood Lead Concentration in Adults (Women of Child-Bearing Age) in the Absence of Exposures to the SKe Soil

ugdL

dimensionless

ugdL

201

09

193

12]

131

12]

BKSF Biokinelic Slope Factor Relating Increase in Typical Adult Blood Lead Concentration to Average Daily Lead Uptake

ugdL per ugday 04 HI

IRs EF AF

AT

Combined Soil and Dust Intake Rate Exposure Frequency Absolute Gastrointestinal Absorption Fraction for Ingested

Lead in Soil Averaging Time for Exposure

gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes

P^fera l 0 95goat ^ aJtilr central goal GSD^y^^ ^ fetal

maternal

B K S F bull m bull A F E F

[1] USEPA 2003 Recommendations ofthe Technical Review Woritgroup for Lead for an Approach to Assessing Risks Associated with Adult Exposures to Lead EPA-540-R-03-001 OSWER Directive 92857-54 value for protection of the fetus to the same level as children Recommended for estimating cleanup goals based on risk to the developing fetus

[2] USEPA 2002 Blood Lead Concentrations of US Adult Females Summary Statistics from Phases 1 and 2 of the National Health and Nutrition Evaluation Survey (NHANES III) Table 3a Values for Northeast Region Non-Hispanic White Subpopulation OSWER 92857-52 March 2002 [3] USEPA 2003 Table 1 - Default value based on Goyer (1990) and Graziano et al (1990)

[4] USEPA 2003 Table 1 - Default value derived from the study of Pocock et al (1983) which based the study between tap water lead concentrations and blood lead concentrations in adult males and the analysis of Sheriock et al (1984) [5] Set to soil ingestion rate listed in Table 6-22 of the Final Additional Site Investigation and Revision of Site Clean-up Goals (Foster Wheeler 2002) [6j Typical construction project duration reflecting 5 days per week for 6 months (PAR 2001)


[8] Most appropriate averaging time for exposures expected to occur over a period less than 1 year Reflects the duration of the constmction activity As recommended by the Technical Review Wortt Group for Lead Guidance Document Frequently Asked Questions (FAQs) on the Adult Lead Model April 1999 Rev 0

2008-O-JV03-0008 TD01-066 522008 Page 2 of 4 3-Tables789xlsCW

TABLE 9 ADULT LEAD MODEL ASSUMPTIONS AND CALCULATIONS FOR THE TRESPASSER


Scenario Timeframe Cun^ntFuture Medium Soil Exposure Medium Surface Soil Exposure Point Any Industrial Property Discussed in the CSM Receptor Population Trespasser Receptor Age Adolescent

1 Parameter Parameter Units Value Rationale Equation


BAV Calculated Risk-Based Cleanup Goal for Lead mgkg 1010 Calculated Adult Lead Model (see Notes)

PbB fetal 095goal Goal for the 95th Percentile Fetal Blood Lead Concentration Among ugdL 10 [11 Fetuses Bom to Women Having Exposures to the Site Soil

GSD i adult Individual Geometric Standard Deviation Blood Lead Level Among ugdL 201 [21 Women of Child-Bearing Age

R fetalmatemal Constant of Proportionality Between the Fetal Blood Lead dimensionless 09 [31 Concentration at Birth and the Maternal Blood Lead Level

PbB adultO Typical Blood Lead Concentration in Adults (Women of Child-Bearing ugdL 193 |2] Age) in the Absence of Exposures to the Site Soil

BKSF Siokinetic Slope Factor Relating Increase in Typical Adult Blood Lead ugdL per ugday 04 [41 Concentration to Average Daily Lead Uptake

IRs Combined Soil and Dust Intake Rate gday 010 [51 EF Exposure Frequency daysyear 120 [6]

AF Absolute Gastrointestinal Absorption Fraction for Ingested dimensionless 012 mLead in Soil

AT Averaging Time for Exposure days 365 181

Notes

p bdquo P^^fe a 0 95gool ^ âduhcen l ra l goa l V 645 Z

l y j i J i adult) -Kfetal maternal

bdquo bdquo _ PbBbdquoî ^bdquobdquo ^ igbdquogi - P b B ^ ^ Q ] bull A T

B K S F bull IR bull A F bull E F

[11 USEPA 2003 Recommendations of the Technical Review Workgroup for Lead for an Approach to Assessing Risks Associated with Adult Exposures to Lead EPA-540-R-03-001 OSWER Directive 92857-54 value for protection of the fetus to the same level as children Recommended for estimating cleanup goals based on risk to the developing fetus

(21 USEPA 2002 Blood Lead Concentrations of US Adult Females Summary Statistics from Phases 1 and 2 of the National Health and Nutritbn Evaluation Survey (NHANES III) Table 3a Values for Northeast Region Non-Hispanic White Subpopulation OSWER 92857-52 March 2002 [3] USEPA 2003 Table 1 - Default value based on Goyer (1990) and Graziano et al (1990)

[4] USEPA 2003 Table 1 - Default value derived from the study of Pocock et al (1983) which based the study between tap water lead concentratbns and blood lead concentrations in adult males and the analysis of Sheriock et al (1984) [5] Set to soil ingestion rate listed in Table 6-26 of the Final Additional Site Investigation and Revision of Site Clean-up Goals (Foster Wheeler 2002)

[6] Set at 120 daysyear to match the original risk assessment assumption The shortest period of time for which the model is to be applied (Technkal Review Work Group for Lead Guidance Document Frequently Asked Questions (FAQs) on the Adult Lead Model April 1999 Rev 0) is 90 days An alternate plausible estimate would be based on total months in which direct contact with surface soil through trespassing is considered plausible (total of 6 monti^s) At 2 daysweek for 3 of the monttis and for 4 daysweek for the other 3 months = 72 daysyear [7] USEPA 2003 Table 1 - Default value based on an absorption factor for soluble lead of 020 and the relative bioavailability of Pb as 06 (soilsoluble) [8] For continuing long term exposures Sufficient for blood lead levels to approach quasi-steady state

2008-O-JV03-0008 TD01-066 522008 Page 3 of 4 3-Tables789xlsAT

1

TABLE 10 SUMMARY OF SITE-SPECIFIC BENCHMARK ASSESSMENT VALUES (BAVs) AND RECOMMENDED CLEAN-UP GOALS (CUGs)

FOR SURFACE SOIL (COMMERCIALINDUSTRIAL LAND USE) SILRESIM SUPERFUND SITE LOWELL MASSACHUSETTS

Calculated Benchmark Assessment Values (BAVs) for Various Receptor and Health Effects Types 1

i Trespasser Trespasser Commercial

Industrial Worker Commercial

Industrial Wortcer Construction

Worilter Construction Woriter Utility Wori(er Utility Worker Most Stringent Basis Practical

Quantitation Policy Recommended Site-Specific Basis

CUG in 2003 Basis

Chemicals of Potential (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic) BAV for Background Concentration (5) Limit (7) Criteria MCP UCL (4) Surface Soil CUG for ESD for Concern (mgkg) (mgkg) (mgkg) (mgkg) (mgkg) (mgkg) (mgg) (mgkg) (mgkg) Value (mgkg) (mgkg) (mgkg) (mgkg) (mgkg) Value (mgkg) Value

TR-C TR-NC CIW-C CIW-NC CW-C CW-NC UW-C UW-NC Mean 95 UCL Maximum 1 1122-Tetrachloroethane 29 57000 23 68000 140 39000 630 1000000 23 CIW-C NA NA NA 0005 400 23 CIW-C 20 RISK Trichloroethene 200 (9) 170 180 (9) 250 960 (9) 81 4700 (9) 5000 81 CW-NC NA NA NA 0005 - 10000 81 CW-NC 190 RISK Trichloroethene 4 (10) 170 31 (10) 250 18 (10) 81 88 (10) 5000 31 CIW-C - - - - - - - - - -124-Trimethylbenzene No Value (1) 180 No Value (1) 320 No Value (1) 73 No Value (1) 9500 73 CW-NC NA NA NA 0005 - 73 CW-NC 73 RISK 135-Trimethylbenzene No Value (1) 44 No Value (1) 76 No Value (1) 18 No Value (1) 4800 18 CW-NC NA NA NA 0005 - - 18 CW-NC 17 RISK Benzo(a )anthracene 75 28000 50 39000 660 21000 690 540000 50 CIW-C 27 79 79 033 - 3000 50 CIW-C 50 RISK Benzo(a)pyrene 75 28000 50 39000 66 21000 69 540000 50 CIW-C 16 57 40 033 - 300 50 CIW-C 5 RISK Benzo(b)fluoranthehe 75 28000 50 39000 660 21000 690 540000 50 CIW-C 40 18 14 033 - 3000 50 CIW-C 50 RISK Dlbenz(ah)anthracene 75 28000 50 39000 66 21000 69 540000 50 CIW-C 024 10 10 033 - 300 50 CIW-C 5 RISK 14Dioxane 320 No Value (1) 260 No Value (1) 4500 No Value (1) 4800 No Value (1) 260 CIW-C NA NA NA 033 - - 260 CIW-C - -Heicachlorobenzene 22 B10 15 1100 140 590 270 15000 15 CIW-C NA NA NA 033 - 300 15 CIW-C 15 RISK 124-Trichlorobenzene No Value (1) 370 NoVahie (1) 620 No Value (1) 150 No Value (1) 18000 150 CW-NC NA NA NA 033 - 9000 150 CW-NC 18 RISK Arsenic 49 380 30 480 270 270 280 7000 30 CIW-C 21 130 130 10 - 200 30 CIW-C 30 RISK Lead NoVahw (1) 1010 (6) No Value (1) 808 (6) No Value (1) 232 (6) No Value (1) No Value (11) 232 CW-NC 380 1554 1970 03 - 3000 380 BKGD 448 RISK Mercury No Value (1) 20 No Value (1) 34 No Value (1) 080 No Value (1) 100 080 CW-NC 077 42 42 004 - 300 080 CW-NC 08 RISK 2378-TCDD 000057 (2) NoVnIiifl (1) 000034 (2) No Value (1) 00048 (2) No Value (1) 0005 (2) No Value (1) 000034 CIW-C NA NA NA 000000052 0005 (8) 0003 0003 MCP-UCL 00002 MCP UCL 2378-TCDD 0000074 (3) No Value (1) 0000045 (3) No Value (1) 000063 (3) No Value (1) 0001 (3) No Value (1) 0000045 CIW-C - - - - - - - - - -Aroclor 1248 27 18 18 26 230 13 240 350 13 CW-NC NA NA NA 002 100 13 CW-NC 13 RISK Aroclor 1254 22 18 15 26 170 13 230 350 13 CW-NC NA NA NA 002 - 100 13 CW-NC 13 RISK

NOTES AND ABBREVIATIONS Italics Candidate CUGs in italic are greater than the MCP UCL Receptors TR = Traspassar CIW Commercitrilndustrial Wortcer CW = Constructk)n Worker UW = Utility Worker Health Effects Types 0 = Carcinooenic NC = Noncarcinoganic - = No Value Identified NA = Not Available CUG = Clean-Up Goal UCU = Upper CcnMsnoe Limit ESP = Explanatkxi of Significafrt Differences Report (September 2003) PQL = Practical Quantitatton Limit BK(3D = Established to be the Site background concentration RISK = Established based on the risk-based BAV POLICY = Established based on USEPA or Mass DEP policy MCP UCL = Established to be the Massachusetts Contingency Plan Upper Concentration Limit (1) BAV not calculated due to lack of pathway-specific toxicological factors (2) Current toxicological carcinogenic slope factor for dioxin published in CalEPA (3) Proposed toxicological carcinogenic slope factor for dioxin in USEPAs 2000 Dioxin Reassessment (4) MADEP UCLs taken from MCP Numerical Standards Spreadsheets - January 2008 http7wwwirtassgovdepseivicecomplianceriskasmthtm (5) 95 UCL calculated using the appropriate method Ijased on normaHtylognormality of data Maximum value shown when data is not normal or lognormal or if the calculated 95 UCL is greater than the maximum measured value (6) Value resulting from the application of the Adult Lead Model (ALM) used per comsspondance with Region 1 Risk Assessor (61107) (7) PQLs extracted from the MettKxi SW-646 References for the chemical family groupings or indnndual chemicals (8) USEPA 1998 Memorandum Approach for Addressing Dkjxin in Soil at CERCLA and RCRA Sites OWSER Directive 92004-26 April - Low-end value of 5 to 20 ppb range recommended for commercialindustrial exposure scenarios Used based on correspondance with Region 1 Risk Assessor (61107) (9) BAV based on CaiEPA toxicity value (2007) (10) BAV based on the upper bound of the CSF range from the EPAs Trichkgtroethylene Health Risk Assessment 2001 per request of Region 1 Risk Assessor (42108) (11) Exposure to lead by this receptor is too infrequent and intermittent to warrant asessment In accordance with Assessing Intermittent or Variable Exposure at Lead Sites (USEPA 2003)

200i-O-IV03-0(m 322008 Plaquogc2or3 total CUGs_0I-07-O8xlsss

TABLE 11 SUMMARY OF SITE-SPECIFIC BENCHMARK ASSESSMENT VALUES (BAVs) AND RECOMMENDED GLEAN-UP GOALS (CUGs) FOR SUBSURFACE SOIL (COMMERCIALINDUSTRIAL LAND USE) SILRESIM SUPERFUND SITE LOWELL MASSACHUSETTS

Calculated Benchmartc Assessment Values (BAVs) for Various Receptors and Health Effects Types 1 Construction Constrijctksn Most Practical Recommended

Wori(er Wortcer Utility Woricer Utility Worker Stringent Basis Quantitation Policy MCP UCL Site-Specific Basis CUG in Basis (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic) BAV for Background Concentration (5) Limit (7) Criteria (4) Subsurface Soil CUG for 2003 ESD for

Chemicals of Potential Concern (mgkg) (mgkg) (mgkg) (mgkg) (mgkfl) Value (mgkg) (mgkg) (mgkg) (mgkg) (mgkg) Value (mgkg) Value

CW-C CW-NC UW-C UW-NC Mean 95 UCL Maximum 1 Benzene 200 68 1000 8300 68 CW-NC NA NA NA 0005 - 9000 68 CW-NC 004 RISK Chtorobenzene No Value (1) 270 No Value (1) 35000 270 CW-NC NA NA NA 0005 - 10000 270 CW-NC 12 RISK Chkxofom 69 220 72000 26000 69 CW-C NA NA NA 0005 - 5000 69 CW-C 0015 RISK 12-Oichtofoethane 7600 8200 440 1000000 440 UW-C NA NA NA 0005 - 6000 440 UW-C 0031 RISK

No Value (1) 220 No Value (1) 29000 220 CW-NC NA NA NA 0005 10000 220 CW-NC 0005 RISK -EthyHwnzencopy No Value (1) 4500 No Value (1) 490000 4500 CW-NC NA NA NA 0005 - 10000 4500 CW-NC 12 RISK

3000 2100 14000 240000 2100 CW-NC NA NA NA 0005 - 10000 2100 CW-NC 056 RISK Styretie No Value (1) 11000 No Value (1) 1000000 11000 CW-NC NA NA NA 0005 - 10000 10000 MCP-UCL 290 RISK 1122-Tetiachloroethane 140 39000 630 1000000 140 CW-C NA NA NA 0005 - 400 140 CW-C 016 RISK Tetrachloroethene 210 560 660 59000 210 CW-C NA NA NA 0005 - 10000 210 CW-C 085 RISK Toluene No Value (1) 14000 No Value (1) 1000000 14000 CW-NC NA NA NA 0005 - 10000 10000 MCP-UCL 11 RISK 111-Trichloroethane No Value (1) 4000 No Value (1) 520000 4000 CW-NC NA NA NA 0005 - 10000 4000 CW-NC 13 RISK 112-Trichloroethane 240 3800 1200 100000 240 CW-C NA NA NA 0005 - 2000 240 CW-C 012 RISK Trichloroethene 960 (8) 81 4700 (8) 5000 81 CW-NC NA NA NA 0005 - 10000 81 CW-NC 025 RISK Trichloroethene 18 (9) 81 88 (9) 5000 18 CW-C - - - - - - - - shyVinyl ChkDride 110 130 990 560000 110 CW-C NA NA NA 0005 - 300 110 CW-C 00062 RISK 12-Dichlorobenzene No Value (1) 2500 No Value (1) 280000 2500 CW-NC NA NA NA 033 - 10000 2500 CW-NC 75 RISK 14-Dioxane 1600 No Value (1) 4800 No Value (1) 1600 CW-C NA NA NA 033 - - 1600 CW-C - -Hexachlorobenzene 140 590 270 15000 140 CW-C NA NA NA 033 - 300 140 CW-C 6 RISK Naphthalene No Value (1) 140 No Value (1) 18000 140 CW-NC 18 36 11 033 - 10000 140 CW-NC 16 RISK 124-Trichlorobenzene No Value (1) 150 No Value (1) 18000 150 CW-NC NA NA NA 033 - 9000 150 CW-NC 1 RISK Lead No Value (1) 232 (6) No Value (1) Not Assessed (10) 232 CW-NC 380 1554 1970 030 - 3000 380 BKGD 448 RISK Mercury No Value (1) 080 No Value (1) 100 080 CW-NC 077 42 42 0040 - 300 080 CW-NC 077 RISK 2378-TCDD 00048 (2) No Value (1) 0005 (2) No Value (1) 00048 CW-C NA NA NA 000000052 0005 0003 0003 MCP-UCL 00002 MCP UCL 2378-TCDD 000063 (3) No Value (1) 000065 (3) No Value (1) 000063 CW-C - - - - - - - - - -Aroclor 1242 150 13 220 350 13 CW-NC NA NA NA 0017 - 100 13 CW-NC 13 RISK

NOTES AND ABBREVIATIONS Italics Candidate CUGs in italics are greater than the MCP UCL Receptors TR = Trespasser CIW = CommercialIndustrial Wortcer CW = Construction Wortcer UW = Utility Wortcer Health Effecte Types C = Carcinogenic NC = Noncxircinogenic - = No Vdue Identified NA=NotAvailabte CUG Clean-Up Goal UCL bull Upper Confidenoe Limit ESD = Explanation of Signifkraquont Differences Report (September 2003) PQL = Practical Quantitation Limit BKGD = Established to be the Site background concentratkin RISK = Established based on the risk-based BAV POLICY = Established based on USEPA or Mass DEP policy MCP UCL= Established to be the Massachusetts Contingency Plan Upper Concentration Limit (1) BAV not calculated due to lack of pathway-specific toxicokgtgical factors (2) Curient toxicofcjgical cananogenic slope factor for dioxin published in CalEPA (3) Proposed toxicological carciriogenic slope factor for dioxin in USEPAs 2000 Dioxin Reassessment (4) MADEP UCLs taken from MCP Numerical Standards Spreadsheets - January 2008 httpwwwmassgovdepservicecomplianceriskasmthtm (5) 95 UCL calculated using the appropriate method based on normalitylognormality of data Maximum value shown when data is not normal or lognormal or if the calculated 95 UCL is greater than the maximum measured value (6) Value resulting from the application of the Adult Lead Model (ALM) used per correspondance with Region 1 Risk ssessor (61107 (7) PQLs extracted from the Method SW-846 References for the chemical family groupings or individual chemicals (8) BAV based on CalEPA toxicity value (2007) (9) BAV based on upper bound of the CSF range from the EPAs Trichloroethylene Health Risk Assessment 2001 per request of Region 1 Risk Assessor (42108) (10) Exposure to lead by this receptor is too infrequent and intermittent to warrant asessment in accordance with Assessing Intermittent or Variable Exposure at Lead Sites (USEPA 2003)

2008-CKJV03O008 Page 3 of 3 lolal CUGs_01-07-Oexlssb 522008

1

1


FOR GROUNDWATER (COMMERCIALINDUSTRIAL LAND USE) SILRESIM SUPERFUND SITE LOWELL MASSACHUSETTS

Calculated Benchmark Assessment Values (BAVs) for Various Receptors and Health Effects Types

Construction Constmction Wortcer Constmction Wortcer Wortcer (open Construction Wortcer Utility Wortcer

(trench) (trench) excavation) (open excavation) (trench) Utility Wortcer (trench) (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic) (carcinogenic) (noncarcinogenic)

Chemicals of Potential Concern (mgL) (mgL) (mgfl) (mgL) (mgL) (mgrt) CWt-C CWt-NC CWoe-C CWoe-NC UWt-C UWt-NC

Acetone No Value (1) 4100 No Value (1) 150000 No Value (1) 110000 Benzene 17 56 43 13 18 150 Chlorobenzene No Value (1) 14 No Value (1) 91 No Value (1) 350 Chloroform 93 20 180 54 10 520 12-Dichloroethane 77 780 64 27000 80 20000 11-Dichloroethene No Value (1) 47 No Value (1) 180 No Value (1) 1200 12-Dichloroethene (total) No Value (1) 58 No Value (1) 58 No Value (1) No Value (1) cis-12-Dichloroethene No Value (1) No Value (1) No Value (1) No Value (1) No Value (1) No Value (1) Ethylbenzene No Value (1) 67 No Value (1) 84 No Value (1) 1700 Hexachlorobutadiene 16 0041 18 0041 16 11 Methylene Chloride 350 240 1200 780 360 6200 1122-Tetrachloroethane 30 160 13 160 15 890 Tetrachloroethene 11 78 11 85 11 720 123-Trichlorobenzene No Value (1) 10 No Value (1) 37 No Value (1) 25 111-Trichloroethane No Value (1) 620 No Value (1) 4600 No Value (1) 16000 112-TrichlorDethane 11 21 59 21 12 560 Trichloroethene 67 (7) 087 160 (7) 093 69 (7) 23 Trichloroetfiene 2 (8) 087 5 (8) 093 21 (8) 23 Vinyl Chloride 79 15 94 28 83 390 14-Dioxane 37 No Vail m (1) 940 No Value (1) 38 No Value (1) Naphthalene No Value (1) 09 No Value (1) 11 No Value (1) 23 124-Trichlorobonzene No Value (1) 10 No Value (1) 36 No Value (1) 25 Arsenic 48 31 48 31 50 800 Cadmium (water) No Value (1) 26 No Value (1) 26 No Value (1) 67 Lead No Value (1) No Value (1) No Value (1) No Value (1) No Value (1) No Value (1) Nickel No Value (1) 410 No Value (1) 410 No Value (1) 11000

NOTES AND ABBREVIATIONS facs Candkiato CUGs in itoNcs are greater than the MCP UCL or the Method 1 GW3 Standard or both Receptors TR = Trespasser CIW = CommerdaVlndustrial Wortcer CW = Construction Wortcer UW = Utility Wortcer Health Effects Types 0 = Cardnoganic NC = Noocardrwgenic - = No Value Identified NA = Not Available CUG = Clean-Up Goal UCL = Upper Confidence Limit ESD = Explanation of SigniAcant Differences Report (September 2003) PQL = Pracitkal Quantitation Limit BKGD = Established to be the Site background concentration RISK = Established based on the nsk-based BAV POLICY = Established based on USEPA or Mass DEP policy MCP GW-3 = Established to be the Massachusette Contingency Plan Groundwater 3 Standard for the protection of ecological resources MCP UCL= Established to be the Massachusette Contingency Plan Upper Concentration Limit SOL = Solubility Limit (1) BAV not calcraquojlated due to lack of pathway-specific toxicological factore (2) BAV Concentration not calculated due to lack of chemical-spedfic data for Volatilzation Factor calculation (3) Limited data obtained from non-impacted wells (eg VOCs) Background concentrations not yet established (4) Solubilities from Soil Screening Guidance (USEPA 1996) or Risk Assessment Information System (RAIS) accessed September 10 2007 (5) MADEP Method 1 GW-3 and UCLs taken from MCP Numerical Standards Spreadsheets - January 2008 httpwwwmassgovdepservicecomplianceriskasmthtn (6) PQLs extracted from the Methcjd SW-846 References for the chemical family groupings or individual chemicals (7) BAV based on CalEPA toxicity value (2007) (8) CUG based on upper bound of the CSF range from the EPAs Trichloroethylene Health Risk Assessment 2001 per request of Region 1 Risk ssessor (42108)

Solubility (4) (mgL)

1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value

CWt-NC CWt-NC CWt-NC cwt-c cwt-c

CWt-NC CWt-NC

SOL CWt-NC CWt-NC CWt-NC cwt-c cwt-c

CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c

CWt-NC CWt-NC CWt-NC CWt-NC

CWt-NC

Background Concentration

(3) (mgL)

NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA

-NA NA NA NA NA NA NA NA

Practical Quantitation

Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040

Policy Criteria (mgL)

-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2

Recommended Site-Specific

Groundwater CUG (mgL)

50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC

MCP GW-3 cwt-c cwt-c

MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC

MCP GW-3 MCP GW-3 MCP GW-3 MCP GW-3

CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK

MCP GW-3 RISK RISK RISK RISK

MCP GW-3 RISK RISK RISK RISK RISK RISK

MCP GW-3 RISK RISK

-RISK

-RISK RISK


2008-O-JV03-000e Page 1 of 3 total CUGs_01-07-O8xlsgw S22008

APPENDIX A

Draft Sample Calculations of

Benchmark Assessment Values (BAVs) for Carcinogenic and Non-Carcinogenic

Health Effect Endpoints

2008-O-JV03-0008

Tetra Tech EC Inc Draft Sample Calculations

Of Benchmark Assessment Values (BAVs) For Carcinogenic and Non-Carcinogenic Health Effect Endpoints

1 Sample Calculations of the Benchmark Assessment Values for Benzo(a)pyrene in Surface Soil to be Protective of a Commerciaiyindustrial Worker

with respect to Non-Carcinogenic and Carcinogenic Health Effects

As presented in Appendix G ofthe 2002 CUG Report the BAVs for surface soil for this receptor assume exposure via incidental ingestion dermal absorption and inhalation of either particulates or volatiles The derivation of Equation INC (for non-carcinogenic COPCs) and Equation Ic (for carcinogenic COPCs) is presented in Appendix F-1 of that document

(INC) BAV bull

THI bull BW bull ATbdquo

EF ED ^^^bullIR^CFX^FlY[y^f^CFVAFÂBS^V bullSAY[y^^^^[yp^pOR y^^^VCF BW

INGESTION TER M DERMAL TER M INHALATION TERM

(Ic) TR BW ATc

BAV EF bull E D bull (SFo -IR bull C F F f ) + ( S F ^ CF ] bull AF ABS EV SA ) + lUR [ypEFOR y v F c F BW j

INGESTION TER M DERMAL TERM INHALATION TERM

The particulate emission factor for this receptor is given by

Q 3600 seel hr PEFshy

(2) 0036 bulli-vyi -^y ^ F)

The PEF for this receptor was taken as the default value from USEPA shown below This value was calculated using Equation 2 with the parameters matched to the characteristics of USEPAs defauh site and location

The volatilization factor for this receptor and the surface soil is given by

Q (314-D -rf^ VF bull C F (3)

(4) D A = p-K)+e^y9-H)

Kbdquo bull ^ o c bull fo i (5)

In general for this Site these three related parameters were calculated on a chemical-specific basis using these relationships when the COPC was determined to be volatile However benzo(a)pyrene does not meet the specified criteria for sufficiently volatile so only the particulate inhalation term (using the PEF) was used in the BAV calculations for benzo(a)pyrene

2008-O-JV03-0008



For benzo(a)pyrene in the surface soil for CommercialIndustrial Workers the following parameters were used

Parameter Description [units] Value

ABSd = Dermal Absorption Fraction [unitless] 013 AF = Adherence Factor of Soil-to-Skin [mgcm^-event] 007 ATc = Averaging Time (Carcinogenic Effects) [days] 25550 ATN = Averaging Time (Non-Carcinogenic Effects) [days] 9125 BW = Body Weight [kg] 70 CFl = Conversion Factor 1 [ 10 kgmg] 1x10-^ CF2 = Conversion Factor 2 [ugmg] 1x10^ CF3 = Conversion Factor 3 [m^cm^] 1x10-^ DA = Apparent Diffusivity [cm^sec] 287x10 (Calculated) Di = Diffiisivity in Air [cm^sec] 430x10^ Dw = Diffiisivity in Water [cmsec] 900x10^ ED = Exposure Duration [years] 25 EF = Exposure Frequency [daysyear] 150 EV = Event Frequency [eventsday] 1 FI = Fraction Ingested from Contaminated Source [unitless] 1 foe = Fraction of Organic Carbon Content of Soil [unitless] 00075 F(x) = Function Dependent on UmUt [unitless] USEPA Defauh PEF used H = Henrys Law Constant [unitless] 463x10^ IRs = Soil Ingestion Rate [mgday] 100 lUR = Cancer Inhalation Unit Risk [ugm^] Not Applicable Kd = Soil-Water Partition Coefficient [cmVg] 765x10^ (Calculated) Koc = Soil Organic Carbon-Water Partition Coefficient [cm^g] 102x10 n = Total Soil Porosity [unitless] 035 Pb = Dry Soil Bulk Density [gcm] 17 PEF = Particulate Emission Factor [m^kg] 132x10(USEPA Default) 0a = Air-Filled Soil Porosity [unitless] 015 0w = Water-Filled Porosity [unitless] 02 QC = Inverse of the Mean Concentration at Center of Square

Source [gm^-sec per kgm^] 487 (USEPA Default) RfC] = Inhalation Reference Concentration [ugm^] Not Applicable RfDo = Dermal Absorption Reference Dose [mgkg-day] 3x10^ RfDo = Oral Reference Dose [mgkg-day] 3x10^ SA = Skin Surface Area Available for Contact [cm^] 3300 SFD = Dermal Cancer Slope Factor [mgkg-day] 730x10deg SFo = Oral Cancer Slope Factor [mgkg-day] 730x10deg T = Exposure Interval [sec] 788x10^ THI = Target Hazard Index [unitless] 1 TR = Target Risk [unitless] 1x10^ Urn = Mean Annual Wind Speed [ms] USEPA Default PEF used U = Equivalent Threshold Value of Wind Speed at 10 m [ms] USEPA Defauh PEF used V = Fraction of Vegetative Cover [unitless] USEPA Defauh PEF used VFs = Soil-to-Air Volatilization Factor [mkg] Not Applicable

2008-O-JV03-0008 - 11



The calculation for Kj using Equation 5 is

llt-d = f oc yoc = 102x10cm^lg00075=765xl0^cm^lg (5)

DA is then calculated using Equation 4

9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)

plS^ bull43x10^ cm^lsec-463xl0-^]+()2deg^ -9x10^ cm^sec]

035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)

The application of a VFs is not appropriate for this COPC because B(a)P does not meet the criteria of being sufficiently volatile (ie having a Henrys Law Constant greater than or equal to 1x10^ atmshymVmole and a molecular weight less than 200 gramsmole) As such this calculation was included onlv for illustration

Equations INC and Ic were grouped into collections of related terms to allow for better presentation ofthe calculations For the non-carcinogenic BAV calculation

(INC) THI BW AT^ BAV = bull

EF ED y I R C F I F l U [ y CFIAF bullABSÊV bull S A U l y bull[yp^ÔR y VCF^^BW

INGESTION TERM DERMAL TERM INHALATION TERM

Incidental Ingestion Term = ynrp bull IRc bull CFI bull FI (6)

= y -lOOmgldaylxlO-kglmglO = 333xlOkglmg 3x10 mg I kg-day

Dermal Absorption Term = yV)r- bull CFl bull AF bull ABS^ bull EV bull SA y ^ D

(7)

= K laquo-2 1x10Jtgffg007ngcw^-evelaquor0131evenr(âv3300cm^ =10x10^ AgVwg i x lO mgkg-day =lt = = -

InhalationTerm= y^y^ bullVpppjCF^ bullBW (8)

= VM 7 -f k-^ r 9 3 |-1000-70tg=0 tgVwg N o Value [ 3 2 x W m f kg) ^ s i s

2008-O-JV03-0008 - I l l



Combining Equations INC 6 7 and 8 (INC)

THI BW AT^ BAV

EF ED y j ^ ^ ^ I R ^ C F l ^ F l ] y y ^ ^ C F l A F A B S E V S A J [ y j ^ ^ [ y ^ ^ O R y ^ y C F B W


1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k

For the carcinogenic BAV calculation (Ic)

TR BW AT BAV

EF bullED (SFa bullIRs bull C F ] F I ) + ( S F C F ^ AF bull ABS J bull EV bull S A ) + IUR IPEFOR yp ] cF BW I

INGESTION T E R M DERMAL TERM INHALATION TERM

Incidental Ingestion Term = SFo bull IR^ bull C F 1 bull F I (9) = 730x10deg [mglkg-dayY bulltOO mgday bullx0^kgmg bull]0 = 730x0kg^mg

DermalAbsorptionTerm = SF ^ bull CF bull AFbull ABS^ bull EVbull SA (]())

= 730x10deg [mg I kg - d a y ] bull 1x10 t g m g 007 mg cm -event 013 bullt event day -3300 cm ^ = 2 1 9 x 1 0 kg^ mg | h

InhalationTerm = IUR bull p ^ p ) - C F l bull BW (11)

= No Value bull V -f 0 bull 1000 bull 70 tg = 0 kg bull i mg

Combining Equations Ic 9 10 and 11 (Ic)

Î 32 xlO m ^ kg

TR BW ATlt BAV

EF ED (SFo IRs bull C F F I ) + ( S F bull C F ^ AF bull ABS J bull EV bull S A ) + IUR 1 BW [ypEFOi^ y v F ^ ^ ^ shy


xW bulllQkg^l5550days bdquo bdquoo bdquo r deg bull mdash mdash rmdash mdash (t= 502x10deg mgg

ISOâyx^T- 25^r-[(730x10 kg mg+ (219x10 kgmg+ (OAgV^^jj

2008-O-JV03-0008



2 Sample Calculations of the Benchmark Assessment Values for Trichloroethene (TCE) in Subsurface Soil to be Protective of a Construction Worker



(INC) THI bull BW bull ATbdquo

BAV = EF ED y ^ ^ ^ I R ^ ^ C F X ^ F I ] [ j j ^ bullCF V AF bull ABS j E V bullSA]-^ RfC PEF OR y bull CF bull BW

INGESTION TER M DERMAL TERM INHALATION TER M

TR BW AT^ (Ic)

BAV EF ED (SFa IRs C F I F I ) (SF^ bull CF I bull AF bull ABS bull EV bull SA )4 IUR V P E F OR^ 1 V F C F BW

INGESTION TER M DERMAL TER M INHALATION TER M


Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)

In general for this site the PEF for each receptor was taken as the default value from USEPA when the COPC was determined not to be sufficiently volatile to require the calculation of a volatilization factor However the COPC TCE does meet the specified criteria for sufficiently volatile (ie having a Henrys Law Constant greater than or equal to 1x10 atm- mVmole and a molecular weight less than 200 gramsmole) and so the PEF for this compound is not used in the BAV calculations This equation is included here for illustration purposes only


Q (314 D^ bull T f (3) VF = ^ bullCF3 C 2p-D)

(4) D A = shy pbKy+0bdquo+0H)

ôc fc (5) f^d = oc J oc

These three related parameters were calculated on a chemical-specific basis using these relationships when the COPC was determined to be volatile As discussed above TCE does meet the specified criteria for sufficiently volatile so the volatile inhalation term (using the calculated VF) was used in the BAV calculations for TCE and is illustrated below

2008-O-JV03-0008



For TCE in the subsurface soil for Construction Workers the following parameters were used


ABSd = Dermal Absorption Fraction [unitless] NA AF = Adherence Factor of Soil-to-Skin [mgcm^-event] 02 ATc = Averaging Time (Carcinogenic Effects) [days] 25550 ATN = Averaging Time (Non-Carcinogenic Effects) [days] 365 BW = Body Weight [kg] 70 CFl = Conversion Factor 1 [kgmg] 1x10^ CF2 = Conversion Factor 2 [ugmg] 1x10^ CF3 = Conversion Factor 3 [m^cm^] 1x10 DA = Apparent Diffiisivity [cm^sec] 205x10^ (Calculated) Di = Diffusivity in Air [cmVsec] 79x10^ Dw = Diffusivity in Water [cm^sec] 91x10^ ED = Exposure Duration [years] 1 EF = Exposure Frequency [daysyear] 130 EV = Event Frequency [eventsday] 1 FI = Fraction Ingested from Contaminated Source [unitless] 1 foe = Fraction of Organic Carbon Content of Soil [unitless] 00075 F(x) = Function Dependent on UnUt [unitless] Not Applicable H = Henrys Law Constant [unitless] 422x10 IRs = Soil Ingestion Rate [mgday] 200 IUR = Cancer Inhalation Unit Risk [ugm^] 200x10 Kd = Soil-Water Partition Coefficient [cm^g] 125x10deg (Calculated) Koc = Soil Organic Carbon-Water Partition Coefficient [cm^g] 166x10^ n = Total Soil Porosity [unitless] 035 71 = Mathematical Constant [unitless] 314159 Pb = Dry Soil Bulk Density [gcm^] 17 PEF = Particulate Emission Factor [mkg] Not Applicable 6a = Air-Filled Soil Porosity [unitless] 015 0w = Water-Filled Porosity [unitless] 02 QC = Inverse of the Mean Concentration at Center of Square

Source [gm^-sec per kgm^] 487 RfCi = Inhalation Reference Concentration [ugm^] 400x10 RfDD = Dermal Absorption Reference Dose [mgkg-day] 300x10 RfDo = Oral Reference Dose [mgkg-day] 300x10^ SA = Skin Surface Area Available for Contact [cm^] 3300 SFD = Dermal Cancer Slope Factor [mgkg-day] 130x10^ SFo = Oral Cancer Slope Factor [mgkg-day] 130x10^ T = Exposure Interval [sec] 315x10^ THI = Target Hazard Index [unitless] 1 TR = Target Risk [unitless] 1x10 Um = Mean Annual Wind Speed [ms] Not Applicable Ut = Equivalent Threshold Value of Wind Speed at 10 m [ms] Not Applicable V = Fraction of Vegetative Cover [unitless] Not Applicable VFs = Soil-to-Air Volatilization Factor [m^kg] 995x10

V I bull2008-O-JV03-0008



The calculation for Kltj using Equation 5 is

I d =ôc -foe = 166x10 c^Vg-00075 = 125x10deg cwV (5)


(4) DA =

p-K)+0^+0^H)

(015deg-79x10-cwVsec bull422x10)H-(02deg-91x10^ cwVsec)

035 = 205x10 cwVsec

(17 gcm bull 125x10deg CW Vg)+ 02 -1- (o 15 bull 422x10)

The volatilization factor (VF) is then calculated using Equation 3

(3) C 2 p D )

^ an t 2 3 (314-205xlGc77sec-315xlOsecr ^4 2 bdquo bdquo ^2 3 VF = 487g m - sec perkg I m-^ 3 oraquoc n-4 2 r ^ bull 10( cw)= 9-95x10mV^g

(2-17^cm -205x10 cm sec)


(INC) THI BW ATbdquo

BAV

EF ED ^^^bullIRsCFX^Flj^[y^^^CFXÂFÂBSÊV^SAy^y^^^[y^ÔRy^J^CF^BW


IncidentalIngestionTerm= Yufn IRs CFl FI (6) RfDo Rlô 1 bull 200 wgpoundaj-1x10 itgwg-10 = 667x10tgVwg ^3x10 mgkg-day

Dermal Absorption Term = Vrri bull CFl bull AF bull ABSJ -EV SA ty^D

= 1 bdquo 4 -IxlO^ kgmg bull02 mgcm -event bullNoValue bull I eventday 3300 cm =000 kg ymg (^) 3x lO mgkg-day

Inhalation Term = j ^ bull Vyp)- CFl bull BW (8)

= K n bull h ^ o m^ 3 lOOOMgmg-70^g = 176x10deg ^gVwg 4x10 mgKg-aoy 1^995x10 m kg J lt= c o 0 1 0

Combining Equations INC 6 7 and 8

2008-O-JV03-0008



(INC) THI BW bull AT

BAV

EF ED bull [yRfD^^-^^-y (XDC^-^^-^^^--^ bullYiRjc ypEpO yvF^^-] INGESTION TERM DERMAL TERM INHALATION TERM

bull70g-365cagt5 810x10ngtg

130poundav5vr-lgtr-[(667x10tg7ng)+(0tgVg)+(l-76x10degtgVg I


TR BW AT^ BAV

EF ED (SFo bull I R s ^ C F ^ F l ) + (SFj bull C F ^ AF bull ABS ^ bull EV bull S A ) + IUR bull | j ^ ^ f OR j ^ ^ c F bull BW


Incidental Ingestion Term = SFo bull IR^ bull CF bull Fl tlt)

= 130x10^ [ m g l k g - d a y Y 100 mgdaybullIxlO kgmg-10 = 160-^ k g m g

Dermal Absorption Term = SFbdquo bull CFl bull AF bull ABS^ bull EV bull SA j QN

= 130x10^ [mg^g-ltâv] bullXxlQ kg mg Olmg cm^ - event bull NoValue bull event day 3300 cm = 000 kg mg

InhalationTerm = IUR bull(IVF)-CF1^BW (11)

= 200x10 bullug m -f I bull 1000 ug mg bulllOkg = 41 xlO kg mg 995x10 m kg


TR BW AT BAV

EF ED (SFg IRs CF ^ F l ) + ( S F bull C F ^ AF bull ABS J EV bullSA)+ lUR bullypEF deg yvF]-^^ BW


1x10 bull 70 ^g bull 25550 pounday5 960x10 mgkg

UOdaysyr -lyr- [(260x10 kgymg)+ (0)tg 7^)+ (1-41x10 V^g)]

2008-O-A03-0008



3 Sample Calculation ofthe Benchmark Assessment Values for Trichloroethene (TCE) in Groundwater (Open Excavation andor Trench) to be Protective of a

Construction Worker with respect to Non-Carcinogenic and Carcinogenic Health Effects

As presented in Appendix G of the 2002 CUG Report the BAVs for groundwater for this receptor assume exposure via dermal absorption and inhalation of volatiles The derivation of Equation INC (for non-carcinogenic COPCs) and Equation Ic (for carcinogenic COPCs) is presented in Appendix F-1 of that document

T H I bull B W A T BAV

E F bull E D bull DA bull C F bull BW y RfD c -E^ - ^ ^ V W R J C VF

DERMAL TERM INHALATION TERM (INC)

(Ic) TR bull BW bull AT c

BAV

E F bull E D ( S F 0 bull DA E V bull SA ) + f IUR C F 2 bull B W event I Cgw VF

DERMAL TERM INHALATION TERM

The absorbed dose per dermal contact event per unit of groundwater concentration (DAeventcgw) for this receptor is calculated using three different equations depending on the volatility ofthe compound and the exposure event duration

For organic compounds

If tevent ^ t thcn

DAêcs = ^FA bull K^ bull CF4 bull j ^ ^ ^ - (2A) V TT

Iftevengttthen

--3B-t-3B DA^^^bdquo ^^FA-K^CF4- bull + 2r (2B)

1 + 5 l^Bf For inorganics or highly ionized organic compounds

D) - fC bull CFd t (2C)

The inhalation volatilization factor (VFglaquo) for this receptor is calculated according to two different exposure scenarios

Where VFgw for standing groundwater to breathing space in an excavation trench is defined as the following

VairD-CF2 VF gw (3A) E^-L

And VFg v for standing groundwater to breathing space in an open air excavation is defined as the following

Q- bull CF3 VF =^-pound (3B)

aveN

2008-O-JV03-0008 IX shy



For TCE in the groundwater at an open excavation for the Construction Worker the following parameters were used

Parameter

ATc ATN

B

BW = CF2 = CF3 = CF4 = D J J A ventCgw~

ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]

Averaging Time (Carcinogenic Effects) [days] Averaging Time (Non-Carcinogenic Effects) [days] Dimensionless Ratio ofthe Permeability Coefficient of a Compound Through the Stratum Comeum Relative to its Permeability Coefficient Across the Viable Epidermis [unitless] Body Weight [kg] Conversion Factor 2 [ugmg] Conversion Factor 3 [m^cm^] Conversion Factor 4 [1 Lcm^] Depth of Excavation Trench [m] Absorbed Dose Per Dermal Contact Event per Unit of Groundwater Concentration [mgcm^-event per mgL] Exposure Duration [years] Exposure Frequency [daysyear] Volatile Emission Rate Calculated Using the WATERS Model (USEPA 1995a) Normahzed to the Area ofthe Trench Bottom and the Dissolved Volatile Chemical Concentration in the Groundwater [(gsec-m^)(mgL)] Event Frequency [eventsday] Fraction Absorbed [unitless] Cancer Inhalation Unit Risk [ugm^] Volatile Emission Rate Calculated Using the WATERS Model (USEPA 1995a) Normalized to the Area ofthe Excavation Bottom and the Dissolved Volatile Chemical Concentration in the Groundwater [(gsec-m^)(mgL)] Dermal Permeability Coefficient of Compound in Water [cmhr] Length of Excavation Trench [m] Mathematical Constant [unitless] Inverse ofthe Mean Concentration at Center of Square Source [gm^-sec per kgm^] Inhalation Reference Concentration [ugm^] Dermal Absorption Reference Dose [mgkg-day] Skin Surface Area Available for Contact [cm ] Dermal Absorption Slope Factor [(mgkg-day)] Time to Reach Steady-State (24Teveiit) [hr] Event Duration [hrevent] Lag Time Per Event [hrevent] Target Hazard Index [unitless] Target Risk [unitless] Average Velocity ofthe Air Flow Through the Trench and Over the Standing Groundwater [ms] Groundwater Volatilization Factor for Standing Groundwater to Breathing Space in an Open Air

Value

25550 365

Not Applicable 70 1x10^ 1x10 1x10^ Not Applicable

191x10 1 130

Not Applicable Not Applicable 1 1 200x10

125x10

120x10^ Not Applicable 314159

487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy



Excavation [m L] 390x10 Since tlttevent for TCE the calculation for DAeventcgw using Equation 2A is

DA ert = ^FA bull K^ bull CFA bull I t l e ^ n T L ^

6 bull 057hr I event bull OSihr I event P^^ bdquo=2- l -1 20xl0 cm r - lx l0Î cm -J = 191x10^mgcm-evewrpermgL

VFg v is then calculated for an open excavation using Equation 3B

_QyCF3 _ 4S7gsec-m^permyi-IxlO^kgmg _ VFbdquo = 3 90xWmyL

oveN 125x10 g s ec -m permgL


THI bull BW AT BAV

EF bull ED XyDbdquo-^^~-c -^^ bull ^ bull ^ j M X y c X F ^ bullc^^-BH


Dermal Absorption Term = pyr- TgtA ( bull EV bull SA (4) RJ-D

= ^ bdquo bdquo bdquo 4 bull9x0~^ mgcm-event permg I L-eventday bull3300cm=2 0x0 kg-Lmg 300x10 mgkg-day

Inhalation Term = 1 ^ - i^^ | - CFl bull BW (5)

X00xl0gg-yayJiX90xl03Lj^deglaquo^^-^deg^ = - ^ ^^-^^

Combining Equations INCJ 4 and 5

THI bull BW AT BAY

E F bull ED y jD bdquo-^^trade -bull bull y y y R c X ^ ^ ^ ^ DERMAL TERM INHALATION TERM (INC)

l -70^g-365^qy5 935x10MgL

n0daysyr^yr-^2 0xW kg-Llmg)+[449x0- kg-Llmg)

2008-O-JV03-0008 - X I bull




TR - BW bull AT cBAV

E F bull ED ( s F bdquo bull DA bdquobdquo ^ bull E V bullSA ) + IUR bull y bull CF 2 bull BW


D e r m a l Absorpt ion Term = SF bull DA^bdquo ^ ^ E V ^ S A (6) = 10 x t O [mg I kg - day ]bull 191 x l O m g c m ^ - e v e n t permg L bulltevent day -3300 cm ^ = 8 1 8 x 1 0 t g - L m g

Inhalat ionTerm = IUR bull X bdquo - C F l bull BW (7)

= 2 0 0 x 1 0 ug I m Y -I I bull1000 ug I mg bull10 kg = 3 5 9 x 1 0 leg - L m g 3 90x10 m bull

Combining Equations Ic 6 and 7 (Ic)

TR bullBW bull AT BAV bdquo =

E F bull ED ( s F bdquo bull DA EV bull SA ) + IUR I bull ^Xrr C F 1 bull BW V F


lx10 bull 70 tg bull 25550 days = 161x10^ wgL

3^daysyr -lyr- [(818x10 kg - Lmg)+ (359x10 kg - Imgj]

2008-O-JV03-0008 - Xll shy

Tetra Tech EC Inc Supplemental Clean-Up Goal Evaluation Silreslm Superfund Site

TABLE OF CONTENTS

L SITE CHRONOLOGYn REVISED AND UPDATED BENCHMARK ASSESSMENT VALUES AND CLEAN-UP GOALS

1 3

TABLES

Table 1 Chronology of Silresim Site Risk AssessmentManagement Activities Table 2 Non-Cancer Toxicity Data - OralDermal Table 3 Non-Cancer Toxicity Data - Inhalation Table 4 Cancer Toxicity Data - OralDermal Table 5 Cancer Toxicity Data - Inhalation Table 6 Determination of VolatiUty for Application of a Volatilization Factor for the Surface

and Subsurface Soil COCs Table 7 Adult Lead Model Assumptions and Calculations for the CommercialIndustrial Worker Table 8 Adult Lead Model Assumptions and Calculations for the Construction Worker Table 9 Adult Lead Model Assumptions and Calculations for the Trespasser Table 10 Summary of Site-Specific Benchmark Assessment Values (B AVs) and Recommended

Clean-up Goals (CUGs) Table 11 Summary of Site-Specific Benchmark Assessment Values (BAVs) and Recommended

Clean-Up Goals (CUGs) Table 12 Summary of Site-Specific Benchmark Assessment Values (BAVs) and Recommended

Clean-Up Goals (CUGs)

APPENDIX

Appendix A Sample Calculations of Benchmark Assessment Values (BAVs) for Carcinogenic and Non-Carcinogenic Health Effect Endpoints

2008-O-JV03-0008 5108



April 30 2008





I Site Chronology




2008-O-JV03-0008 5108






2008-O-JV03-0008 5108











2008-O-JV03-0008 3 5108












2008-O-JV03-0008 5108











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy



April 30 2008





I Site Chronology




2008-O-JV03-0008 5108






2008-O-JV03-0008 5108











2008-O-JV03-0008 3 5108












2008-O-JV03-0008 5108











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy






2008-O-JV03-0008 5108











2008-O-JV03-0008 3 5108












2008-O-JV03-0008 5108











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy











2008-O-JV03-0008 3 5108












2008-O-JV03-0008 5108











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy












2008-O-JV03-0008 5108











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy











2008-O-JV03-0008 5 5108












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy












2008-O-JV03-0008 6 5108









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy









2008-O-JV03-0008 5108





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy





Construction Worker





2008-O-JV03-0008 8 5108









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy









2008-O-JV03-0008 5108



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy



2008-O-JV03-0008 10 5108


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy


REFERENCES
















2008-O-JV03-0008 l l 5108



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy



2008-O-JV03-0008 12 5108


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy


TABLES


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy


DATE 1978-1982

1983-1984

1984

1986

March 1990

September 19 1991

February 1999

May 2001

June 8 2001



Record of Decision







2008-O-JV03-0008


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy


DATE 1 August 13

2001

1 August 14 2001

November 2001

December 20 2001

January 2002

March 19 2003

May 14-15 2003

September 2003

October 2004





Scope of Work







2008-O-JV03-0008

1



February 19 2008




2008-O-JV03-0008





Concern RfD (2)

































Primary

Target

Organ

Kidney

White Blood Cells

Developmental

Liver

NA

Liver

None

NA

Liver

NA

NA

Liver

Liver

Liver and Kidney

Kidney

Kidney

Kidney

Liver


NA

NA


Respiratory

Liver

Kidney

Reduced Body

Weight

Liver

NA

NA

NA

Liver

Increased mortality

Combined


Factors

1000

300

1000

300

NA

100

None

NA

100

NA

NA

1000

1000

1000

1000

1000

1000

100

3000

NA

NA

1000

1000

1000

3000

1000

1000

NA

NA

NA

30

1000

Sources of RfD

Target Organ

IRIS

IRIS

IRIS

PPRTV

NA

IRIS

PPRTV

NA

IRIS

PPRTV (13)

PPRTV

IRIS

ATSDR

IRIS

HEAST

IRIS

IRIS (4)

IRIS

HEAST

NA

USEPA (12)

IRIS

ATSDR

IRIS

IRIS

IRIS

IRIS

USEPA (1217)

USEPA (12)

USEPA (12)

IRIS (18)

IRIS

Dates of RfD

Target Organ (3)

(MMDDYY)

091807

091807

091807

091707

NA

091807

091707

NA

091807

091707

091707

091807

051805

091807

073197

091807

091807

091807

073197

NA

5122005

091807

080196

091807

091807

042308

042308

051205

051205

051205

091807

091807







Concern




























Chemical

of Potential

Concern

A luminum

Antimony

Arsenic

Barium


Cadmium (water)

Chromium (total)

Copper

ead

Ulanganese Mercury

Mickel Selenium

rhallium Vanadium

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

3eta-BHC delta-BHC

Chlordane


-leptachlor

Heptachlor Epoxide

Jndane (gamma-BHC)

2378-TCDD

Chronic

Subchronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic

Chronic NA

NA

Chronic NA

Chronic

Chronic

Chronic

Chronic

NA

Oral RfD

Value

100E+00

400E-04

300E-04

200E-01

200E-03

100E-03 500E-04

300E-03

NA NA

140E-01

300E-04

200E-02

500E-03

800E-05

700E-03

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03

NA

NA 500E-04

NA 600E-03 500E-04

130E-05

300E-04

NA

Oral RfD

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA NA

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

NA MGKG-DAY

NA MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA


100

15

100

7

1

3

5 3 NA

NA

4

7

4 100

100

3

100

100

100

100

100

100 NA

NA

100 NA

100

100

100

100

NA

Adjusted

Dermal

RfD (2)

100E+00

600E-05 300E-04

140E-02

140E-05

250E-05

250E-05 750E-05

NA

NA 560E-03

210E-05

800E-04

500E-03 800E-05 182E-04

200E-05

200E-05

200E-05

200E-05

300E-05

800E-03 NA NA

500E-04

NA

600E-03

500E-04

130E-05

300E-04

NA

Units

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

NA NA

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY NA

NA

MGKG-DAY NA

MGKG-DAY

MGKG-DAY

MGKG-DAY

MGKG-DAY

NA

Primary

Target

Organ


Longevity

Skin

Kidney

Small Intestine

Proteinuria

Proteinuria None NA

NA

CNS


Selenosis

None NA





Liver

Liver

NA NA

Liver NA

Body weight

Liver

Liver

LiverKidney

NA

Combined


Factors

100

1000

3

300

300

10

10

900 NA

NA 1

1000 300

3

3000 100

300

300

300

300

1000

100 NA NA

300

NA

100

300

1000

1000

NA

Sources of RfD

Target Organ

PPRTV

IRIS

IRIS

IRIS IRIS

IRIS

IRIS

IRIS (8) NA

NA

IRIS

IRIS (9)

IRIS IRIS

IRIS (16) HEAST

IRIS (11)

IRIS (11)

IRIS

IRIS (11)

IRIS

ATSDR NA

NA IRIS

NA

IRIS (14)

IRIS

IRIS

IRIS

NA


(MMDDYY)

9172007

091807

091807

091807 091807

091807

091807 091807

NA

NA 091807

091807

091807 091807

091807

073197

091807

091807

091807

091807

091807

052405

NA

NA 091807

NA 091807

091807

091807

091807

NA


































































Weight Gain











































































































Chemical

of Potential

Concern

Aroclor-1242

Aroclor-1248

Aroclor-1254

Aroclor-1260

Aldrin

alpha-BHC

beta-BHC

delta-BHC

Chlordane

4-4-DDE

Endosulfan sulfate

Heptachlor

Heptachlor Epoxide

Lindane (gamma-BHC)

2378-TCDD

2378-TCDD


C19-C36 Aliphatics

C5 - C8 Aliphatics





200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350Y0V

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Oral to Dermal

Adjustment

Factor

100

100

100

100

100

100

100

NA

100

100

NA

100

100

100

100

100

NA

NA

NA

NA

NA

NA

Adjusted Dermal


200E+00

200E+00

200E+00

200E+00

170E+01

630E+00

180E+00

NA

350E-01

340E-01

NA

450E+00

910E+00

110E+00

130E+05

100E+06

NA

NA

NA

NA

NA

NA

Units

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

(MGKG-DAY)-1

NA

NA

NA

NA

NA

NA

Cancer Guideline

Description

B2

B2

B2

B2

82

82

C

D

82

82

NA

82

B2

82

-B2

NA

NA

NA

NA

NA

NA

Source

Target Organ

USEPA (9)

USEPA (9)

USEPA (9)

USEPA (9)

IRIS

IRIS

IRIS

IRIS

IRIS

IRIS

NA

IRIS

IRIS

CaiEPA

CalEPA


NA

NA

NA

NA

NA

NA

Date of Slope

Factor (2)

(MMDDYY)

051205

051205

051205

051205

091807

091807

091807

9182007

9182007

9182007

NA

9182007

091807

091907

091907

090100

NA

NA

NA

NA

NA

NA













- laquo ^

TABLE 5





Acetone NA NA NA NA





















Styrene NA NA NA NA



Toluene NA NA NA NA


























Phenol NA NA NA NA





TABLE 5








Barium NA NA NA NA





Copper NA NA NA NA

Lead NA NA NA NA


Mercury NA NA NA NA

















44DDE 400E-05 B2 CalEPA 121707





2378-TCDO 33E-05 B2 HEAST 122107












TABLE 6






Concern H H MW











754E-01 184E^)2 1658 YES YES YES



















237S-TCDD 204E-03 498E-05 3220 YES NO NO




Arsenic

3arium

Cadmium (food)

Chromium (total)

Copper

Lead

Manganese

kêrcury

ThattHjm







Footnotes








200ampO-JV03-0008
















BKSF - m - A F EF

Units

mgkg

ugdL

ugdL

dimensionless

ugdL

ugdL per ugday

gday daysyear

dimensionless

days


808 Calculated

10 i)

201 [2]

09 [31

193 [21

04 [4)

010 151 150 [6]

012 [7]

365 mdash m mdash

Equation

Model Name


II

















mgkg

ugdL

232 10

Calculated

11)


GSD 1 adult

R fetalmatemal

PbB adultO




ugdL

dimensionless

ugdL

201

09

193

12]

131

12]



IRs EF AF

AT



gday daysyear

dimensionless

days

020 130 012

182

[51 [61 [71

12

Notes


maternal






















Notes










1









CUG in 2003 Basis














1

1










1000000 1750 472

7920 8520 2250 NA

3500 169 323

13000 2970 200 300

1330 4420 1100 1100 2760

1000000 31 300 NA NA NA NA

Most Stringent

BAV (mgL)

4100 56 14 93 77 47 58

3500 67

0041 240 30 11 10 620 11

087

-79 37

089 10 31 26

410

Basis for

Value


CWt-NC CWt-NC


CWt-NC CWt-NC cwt-c

CWt-NC

_ cwt-c cwt-c


CWt-NC


(3) (mgL)




Limit (6) (mgL)

0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005 0005

-0005 025 001 0005 0010 0005

00030 0040


-------------------------

MCP Method 1

GW-3 Standard

(5) (mgL)

50 10 1 10 20 30

-50 4 3

-50 30

-20 50 5

-50

-20 50 09

0004 001 02

MCP UCL (5)

(mgL)

100 100 10 100 100 100 100 100 100 30 100 100 100

-100 100 50

-100

-100 100 9

005 015

2



50 56 1

93 77 30 58 50 4

0041 100 30 11 10 20 11

087

-79 37

089 10

090 0004 001 02

Basis for

Value

MCP GW-3 CWt-NC


MCP GW-3 CWt-NC

MCP GW-3 MCP GW-3

CWt-NC MCP-UCL

CWt-C CWt-C

CWl-NC MCP GW-3

CWt-C CWt-NC

-CWt-C cwt-c

CWt-NC CWt-NC


CUG in 2003 ESD

(mgL)

50 048 05 02 05

0015 120 50 34

0041 14

061 5

38 50 11 14

-013

-089 015 04 001 003 008

Basis for

Value

MCP GW-3 RISK



MCP GW-3 RISK RISK

-RISK

-RISK RISK



APPENDIX A




2008-O-JV03-0008






(INC) BAV bull




(Ic) TR BW ATc





(2) 0036 bulli-vyi -^y ^ F)




(4) D A = p-K)+e^y9-H)



2008-O-JV03-0008







2008-O-JV03-0008 - 11






9yyDrH)4pîyDj (4)

p -K ) + e^+(6-H)


035 ^ = 287x10 cm^ I sec

[l7gcm^ -765x10^ cm^g)--02+ [ol5-463x10-^)









(7)




2008-O-JV03-0008 - I l l




THI BW AT^ BAV



1 bull 70 g-9125^0^5 ^ _ _ _ ^ _ = 3 93x10w k


TR BW AT BAV









Î 32 xlO m ^ kg

TR BW ATlt BAV





2008-O-JV03-0008









TR BW AT^ (Ic)




Q 3600 secjhr PEF =

(2) ^ 0036^l-V^y^^^ -Fix)







2008-O-JV03-0008







V I bull2008-O-JV03-0008






(4) DA =

p-K)+0^+0^H)


035 = 205x10 cwVsec



(3) C 2 p D )


(2-17^cm -205x10 cm sec)



BAV









2008-O-JV03-0008




BAV





TR BW AT^ BAV










TR BW AT BAV





2008-O-A03-0008










BAV





If tevent ^ t thcn


Iftevengttthen









aveN

2008-O-JV03-0008 IX shy




Parameter

ATc ATN

B


ED EF EN =

EV FA IUR JaveN

Kp

L n QC

RfC RfDo SA SFD

t êvent

êvent

THI TR V bull V air

VF gw

Description [units]


Value

25550 365


191x10 1 130


125x10


487 400x10 300x10^ 3300 130x10^ 139 058 057 1 1x10

Not Applicable

2008-O-JV03-0008 X shy










THI bull BW AT BAV








THI bull BW AT BAY


l -70^g-365^qy5 935x10MgL


2008-O-JV03-0008 - X I bull
















2008-O-JV03-0008 - Xll shy

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