Technology Development Support Center

University of Brasilia

CDT/UNB FACTS

CDT/UnB year of foundation: 1986.

NIT, year of foundation: 2007.

Our first Technology Transfer happened in 2006 - BIOMM Technology.

September 2014:

• 2 Technology Transfers.

• Up to 8 Technologies under negotiation.

The University of Brasília is looking for strategic partners in the industry to develop a joint work focused on finding solutions to real problems.

LIFESCIENCE NUMBERS

• 1.996 Professors;

• 1.184 Research lines;

• 147 Labs and Research Centers;

332 Protected Assets: 128 National Patents;

50 International Patents;

16 Cultivares;

78 Patents in Lifescience.

30 Technologies Brought to Bio Latin America:

THE POISON THAT HEALS

→ The technologies present new peptides with improved analgesic, antiepiletic and antidepressive activities concomitant with reduced side effects.

→ Industry for Neuropharmacology.

→ New studies are being conducted for Parkinson and Alzheimer.

BR 10 2014 020348 6, 18.08.2014 (Embrapa),

BR 10 2014 020352 4, 18.08.2014 (Embrapa),

BR 10 2014 020510 1, 21.08.2014 (Embrapa),

BR 10 2014 004728 0 (27.02.2014).

THE POISON THAT HEALS

→ The technologies present new peptides with improved analgesic, antiepiletic and antidepressive activities concomitant with reduced side effects.

→ Industry for Neuropharmacology.

→ New studies are being conducted for Parkinson and Alzheimer.

BR 10 2014 020348 6, 18.08.2014 (Embrapa),

BR 10 2014 020352 4, 18.08.2014 (Embrapa),

BR 10 2014 020510 1, 21.08.2014 (Embrapa),

BR 10 2014 004728 0 (27.02.2014).

KITS FOR DIAGNOSIS

1. Dengue, BR 10 2014 018609 3, 29.07.2014

→ Reduced false negatives and identification of early-stage disease;

→ Good reactivity to DENV-4.

2. Chagas Disease, PI 0603871 9 / PI 06038727, 08.2006

→ Better diagnosis of the disease stage.

3. LDL Diagnosis, BR 10 2012 025132 9, 10.2012 (USP, UFRGS)

→ Arterosclerosis Treatment;

→ Antinflamatory response.

FROM BIOMASS TO THE MARKET

Enzymes Production (BR 102012012193-0, 22.05.2012)

→ Application in many industries: chemical, textile, food, among others.

→ Increase up to 13x the production and secretion of cellulolytic and xylanolytic enzymes of fungi;

Macauba Feed (BR 102012029493-1, 20.11.2012)

→ Reduction in spending on animal feed, which represents up to 40% of the cost of production of meat and milk.

Capsules of Pequi Pulp (PI 0601631-6, 31.01.2006)

→ Vitamin supplement with antioxidant and antimutagenic properties;

FROM BIOMASS TO THE MARKET

Enzymes Production (BR 102012012193-0, 22.05.2012)

→ Application in many industries: chemical, textile, food, among others.

→ Increase up to 13x the production and secretion of cellulolytic and xylanolytic enzymes of fungi;

Macauba Feed (BR 102012029493-1, 20.11.2012)

→ Reduction in spending on animal feed, which represents up to 40% of the cost of production of meat and milk.

Capsules of Pequi Pulp (PI 0601631-6, 31.01.2006)

→ Vitamin supplement with antioxidant and antimutagenic properties;

• Derived from L latic acid polymerization;

• Expanding market: 2007 – U$ 1bi;

2020 – U$ 10bi;

POLY(LACTIC ACID) PRODUCTION FROM CRUDE GLYCEROL (BR1020120310522)

Glycerol P.A. Crude Glycerol Pichia pastoris

Advantages:

• High crude glycerol consumption;

• High cell densities;

• Easy genetic manipulation ;

• GRAS status;

Glycerol

Glycerol Dihydroxycetone

Glyceraldehyde 3-P

Pyruvate

Acetaldehyde

Ethanol Acetate

Acetyl-CoA

Lactic acid

TCA

Biomass

LDH

POLY(LACTIC ACID) PRODUCTION FROM CRUDE GLYCEROL (BR1020120310522)

INTRODUCTION OF LDH ACTIVITY IN PICHIA PASTORIS (BR1020120310522)

Enzyme activities

Fermentation profile of clone B5

PHOTODYNAMIC THERAPIES FOR CANCER TREATMENT

BR 102012028363-8, 06.11.2012

BR 102012021043-6, 22.08.2012

BR 10 2012 0210410, 10.2012

→ Biocompatibility;

→ Bioadhesiveness;

→ Facilitated transport;

→ Selectivity to tissue / target cell;

→ Photodynamic activity in biological environment in the red-infrared range after excitation with light at a specific wavelength;

→ Application on diagnosis and treatment of cancer lesions.

NANOFORMULATIONS FOR CANCER TREATMENT

PI 1100733 8 (USP, UFG)

BR 10 2012 02 1044 4, 10.2012

BR 10 2012 01 9716 2, 10.2012 (USP)

BR 10 2013 02 8596 0 – 10.2013

BR 10 2013 01 7103 0 - z0.2013 (UFMG)

→Reduce systemic toxicity and undesirable effects on the body in non-neoplastic cells;

→Bioadhesiveness, transport, tissue selectivity / target cell activity and activity to eliminate or reduce the microbial load;

→ Improved drug delivery;

→Dose Reduction;

→Improved cancer diagnosis;

→ Biocompatible and biodegradable nanoparcicles.

MYCOSIS TREATMENT Nanocoated Composition of Antifungal Immobilized in Polimeric Blend For Treatment Of

Mycoses (PI 1101309-5, 04.03.2011)

→ Greater therapeutic efficacy due to gradual and controlled drug release through nanostructuring of conventional drugs;

→ Decreased toxicity;

→ Medicated compositions in various vehicles such as ointments, creams, emulsions, injection and others;

Nanostructured Composition Based on the Immunoprotective Peptide P10 Immobilized in

Polimeric Blend For Treatment Of Mycoses (PI 1003192-8, 18.02.2010)

→ Efficiency and effectiveness in immune response;

→ Reduced side effects;

→ Need low-doses for results.

THE LATEX USE IN BIOMEDICAL ENGINEERING

Insoles for Diabetics feet care :

Damping (PI 1103692-3, 18.07.2011)

Sensorized (PI 1103691-5, 18.07.2011)

Healing (PI 1103690-7 , 18.07.2011)

Occluding Contact Lens derived from latex, focusing on the treatment of amblyopia in children (BR 102012007483-4, 02/04/2012).

Other researches with latex in progress: → Adhesive for diabetic foot. → Temperature analysis using Symbolic Dynamics in the prevention of

Esophageal Cancer. → Orthodontic prototype for mandibular pressure control. → Latex Glove for diabetic hand.

TECH PARK – PCTEC/UNB

→Created in July 2013; →1st Public Notice of Competition in Abril 2014.

TECH PARK – PCTEC/UNB

→Created in July 2013; →1st Public Notice of Competition in Abril 2014.

Thank You!

Camila Lisdalia D. Ferreira camila.dantas@cdt.unb.br

www.cdt.unb.br/vitrinetecnologica +55 61 3107 4116