Technology Transfer from the University of Oxford

Gurinder Punn &

Rakesh Roshan

Isis Innovation Ltd

Oxford Technology TransferIP, Patents, Licences, Spin-outs, Material Sales, Seed Funds, Isis Angels Network

Oxford ExpertiseConsulting, Services

Isis Consulting Business Technology Transfer and Innovation Management

A company 100% owned by the University of Oxford

Isis Innovation 2000 - 2009

Year Ending Mar: 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009

University Investment £m

£1m £1m £1m £1m £1m £1.2m £1.2m £1.2m £1.2m £2.5m

Staff 17 21 23 34 36 36 36 37 44 54

Open Projects 319 415 476 629 725 764 784 841 978 1112

Patents filed 55 63 82 65 52 55 57 49 68 64

Licence Deals 21 36 42 37 31 38 45 50 74 69

Consultancy 34 50 48 59 89 102 151

Spin-outs 6 8 8 7 3 4 6 7 4 4

Annual T/ O £ £0.9m 1.2m 1.7m 2.0m 2.3m 2.7m 2.9m 3.6m 4.8m 5.6m

Intellectual Property Policy

• University claims ownership of all employees’ and students’ IP rights resulting

from University research activities

• The University assists those researchers who wish to commercialise their

research

• by patenting, licences, spinout companies & consultancy

• Researchers share the benefits

• Royalty shares from licences

• Equity in spinout companies

• Income from personal consultancy

Steps to Commercialisation

Disclosure meeting IP forms & Invention record

Marketing

Market research

Commercial interest

Yes?

No?

Research Services Due diligence

University assigns IP to Isis

Type of deal?Negotiate termsLegalsFinalise deal!

Understand why:more research needed?reposition

IP protection Patents, copyright, database right

Licensing

• Choosing licencees: Need, Intent and Budget

• Licensing technology to industry: fosters new industrial links for the research group

• Negotiating appropriate deal terms and passing royalties back to the University for distribution to the Researcher, Department and University

Versatile Microwave Amplifier License

£50 X 10,000 = £0.5 m

Technology Licensing

Total net Researchers University Department Isis revenue personally General Fund Funds Innovationto £72k 61% 9%* 0% 30%

to £720k 31.5% 21% 17.5% 30%

over £720k 15.75% 28% 26.25% 30%

* pays National Insurance employment tax

• Licensing out of University of Oxford Intellectual Property Rights

• Isis currently manages 1,320 Patents & Patent Applications; and 330 active licensing deals

• Technologies marketed to Oxford Innovation Society Members and then other companies

• Licence partners selected on

• Resources and intent to develop technology to market

• In healthcare, awareness of access of final products to developing countries

• Exclusive & Non-exclusive, Geographical Territory and Technology Field controls

• Fees, milestones, running royalties appropriate to technology and marketplace

• Royalties• Patent budget £2.5m per annum & royalties• Isis pays patent costs & recovers these from royalties

Spin-out Companies

Occasionally a spin-out can be a more appropriate route to commercialisation as opposed to a licensing agreement

Successful spin-outs involve:• Significant time and effort• Business and management skills• Legal responsibilities which are potentially onerous• A measure of luck

Oxford Spin-outs (post 2000)

2000 7Third Phase, Mindweavers, Oxford BioSignals, Oxford BioSensors, TolerRx, OXIVA, Pharma DM

2001 7OxLoc, Oxford Bee Co, Oxford Ancestors, Novarc, Oxford ArchDigital, Natural Motion, Inhibox

2002 9Pharminox, Minervation, Oxford Biomaterials(Spinox), Zyentia, Oxitec, Oxford Immunotec, Oxford Risk, GlycoForm, BioAnalab

2003 4 Summit(Vastox)* , ReOx, Riotech, OCSI

2004 4 Avacta(OMD)* , G-Nostics, Surface Therapeutics, EKB Technology

2005 5Oxford Nanopore Technologies, Oxford RF Sensors, Oxbridge Pulsars, Celleron, Oxford Catalysts*

2006 7TDeltaS, Oxford Medistress, Particle Therapeutic, Aurox, Oxford Advanced Surfaces* , Cytox, OxTox

2007 4 Eykona Technologies, Clinox, Oxford Biodynamics, Crysalin

2008 4 Semmle, Oxford-Emergent TB Consortium, Navetas(ISE), Organox

2009 3 Oxford Financial Computing, Zyoxel, Oxford Yasa Motors

2010 [3] OxEms, Kepler Energy, IXO

Total external investment to date in 56 spin-outs since 2000: £268m £38m 1st round Seed/Business Angels – average amount invested £850k; 1/3rd > £1m invested.£230m follow-on Venture/Institution Capital * stock exchange listing

The Opportunity

Enough pipes and cables below ground in Britain to stretch to the Moon and back 10 times.

OxEmS Solution

OxEmS Limited offers a low cost, versatile and accurate solution for managing underground assets such as pipes and cables.

Lead academic Prof David Edwards - Engineering Science Department.

Bar Coding

(ISIS Innovation, 2009)

Tx Rx

• All “green technology” similar to photosynthesis.

• Screen printing process compatible with glass manufacturing.

• Wide range of colours and transparency options.

Oxford Photovoltaics Limited – Hybrid organic and inorganic

© Oxford Photovoltaics Ltd. - Confidential

OxEMA: MRI Quality Images at the price of Ultrasound

Simultaneous Ultrasound and EMA image

of a kidney: Calcium Carbonate nodule inclusion

Calcium carbonate nodule

Academic consultancy at Oxford

• The University’s strategic objective of engaging with society recognises that consultancy complements teaching and research

• Researchers may undertake up to 30 days of personal consultancy per year

• The University has statutes and guidelines governing researchers’ personal consultancy activities (e.g. approval & conflict of interest)

• The University endorses OUC as the preferred route for researchers to manage their consultancy activity…

http://www.admin.ox.ac.uk/rso/consultingactivity/

OUC - purpose

Purpose:

To provide a University endorsed service to researchers and departments to support their external consultancy & services work.

OUC - benefits

Benefits:

• Protecting your interests by aligning expectations and managing all contractual, IP & legal issues

• Providing you with insurance cover

• Negotiating & securing for you competitive rates & terms

• Addressing Governance requirements – University approval, conflicts of interest checks

• Handling client invoicing, consultant payment & client debt collection

• Helping to identify and develop consultancy opportunities through our strategic client relationships & support tender requests

Protecting interests & developing opportunities…

Helping external clients

• Acting as a gateway to the University - identifying for clients the right expertise or service to address their challenges & requirements

• Enabling clients to contract with a limited company & providing a professional administrative front end (ISO 9001)

• Providing reassurance that contractual & governance issues are addressed:

• Single point of contact throughout the lifecycle• Protecting interests – commercial confidentiality & IP ownership • University approval, conflicts of interest & insurance

Invoicing, fees & payment

• OUC invoices clients & chases debt, if required

• We charge a management fee of 15% of invoiced fees

• Fees can be disbursed, either:

•Directly to academics as ‘self-employed’ consultants or•To a departmental cost centre

Clients across all sectors

• OUC counts amongst its clients:

• Astra Zeneca• BASF• Bayer Schering Pharma• BBC• Capgemini• GlaxoSmithKline• Microsoft

• National Audit Office• Novartis• Becton Dickinson• Qinetiq• Sharp Laboratories of Europe• UN Development Programme• Unilever

• Expert Witness

• Discrete Problem Solving

• Technical Due Diligence

• Blue Sky Thinking

• Quality Assurance

• Literature Reviews

• Departmental Services

Consultancy Examples

Contact details

Oxford University ConsultingIsis Innovation LtdEwert HouseEwert PlaceSummertownOxford OX2 7SG

Gurinder PunnT: 0044 1865 280826F: 0044 1865 280828E: gurinder.punn@isis.ox.ac.uk

www.isis-innovation.comwww.isis-innovation.com/consulting/index.html