emka TECHNOLOGIES telemetry.emka.fr

telemetry for small & large animals

ecg, eeg, emgrespiration

blood pressureaccelerationskin & core temperature

40°

37°

32°

emka TECHNOLOGIES

telemetry solutions from emka TECHNOLOGIES

iox acquires, analyzes, displays, controls and stores data generated during an experiment.

» one file per subject (can append data to same file during successive sessions) » subject file contains all information (configuration, calibration, protocol, event

and signal data) » real-time monitoring, on line or off line review » synchronized video signal stored in same file or in separate file (user option) » easily identified subjects with matching numbers on their jacket

studyDESIGNER is a high level tool to organize data recording, analysis, review and archiving on large toxicology or safety pharmacology studies.

During recording sessions, studyDESIGNER automatically drives iox and ecgAUTO software to record and analyze data and send calculated parameters to its data base.

» fast, reliable and in-depth analysis of ECG and non-ECG signals

» for all species, leads, normal and pathological morphologies

» pioneering shape-recognition techniques for powerful analysis

» synchronized video review

Powerful, fast, reliable ECG analysis » beat-by-beat , single, inter and multi lead analysis » detects arrythmias, isolated p-waves, abnormal events » full range of parameters (intervals, amplitudes, areas, …) » predifined or customized subject specific parameter (QTc) » extensive data review, edition, export modes » automated protocol and batch analysis of successive files

Large choice of analysis modules beyond ECG

» blood pressure or flow, ventricular pressure, action potential » respiration from conductive belts or whole body plethysmograph » EEG/EMG for sleep scoring, epilepsy detection, FFT measurements » NIBP oscillometric blood pressure from cuff

» defines subject and study structure » defines recording protocols and analysis configurations » reviews and edit analysis results » stores and archive results in database » generate on-demand/custom reports for any combination

of group, phase, subject and all parameters

ecgAUTO, advanced post-processing analysis

studyDESIGNER, data base tool for your studies

software suite for all your needs

iox, data acquisition and real-time analysis

GLP modules Available for all software

» electronic signature » audit trail » user access management » study management

service & support emka TECHNOLOGIES provides a full range of support services

» pre-installation audits to design optimal system setup, SOP » installation and training » hardware and software validation service » warranty extension, maintenance, and recalibration

emka TECHNOLOGIES

telemetry solutions from emka TECHNOLOGIES

emkaPACK4G, noninvasive telemetry for large animals

emkaPACK4G telemetry monitors the physiology of large animals noninvasively (no surgery).

It only takes a few minutes to equip the animals with emkaPACK4G using our custom-designed clothing.

The emkaPACK4G transmits ECG, lung volume, blood pressure, acceleration and temperature signals.

Each signal type is available as an optional add-on, so you buy only what you need and can upgrade at any time.

Strong

Up to 17 signals produced simultaneously

» 9 lead ECG » 2 respiration belts signals » 3 axis + total acceleration, to assess activity and posture » skin or core temperature » blood pressure from 3 methods:

- noninvasive with oscillometric cuff (NIBP) - semi invasive with vascular access port (VAP) - minimally invasive with batteryless implant (MIBP)

Smart

» only 1 receiver for 16 animals » only 1 Ethernet cable per receiver » 32 to 48 subjects per room, group or single housed » automated software configuration according to selected hardware » remote on/off of individual transmitters and measurement option » warning on lost electrode and low battery, with optional e-mail

emission

For large animals

» dogs, primates, pigs, sheep, rabbits

emkaPACK4G receiver

emkaPACK4G transmitter

transmitter technical characteristicsdimensions 106 x 61 x 25 mm

weight (with batteries) 170 g

transmission range 10 m

battery life 48 to 72 hours

sampling frequency up to 2kHz/signal

network

emkaPACK4G typical setup

NIBP oscillometric blood pressure module

RIP respiration option

Blood pressure (NIBP) measurement from noninvasive cuff:

» proven and validated noninvasive oscillometric cuff method » proprietary software for analysis and control » 60 to 90% of cycles provide reliable data » automated rejection of unstable cycles » only system to measure NIBP in ambulatory animals

bptVAP vascular access port blood pressure module temperature module

Blood pressure measurement via vascular access port (VAP):

» easy connection to implanted arterial VAP » no transducer drift, easy calibration » up to 2 measurement points per animal

» core temperature from implanted probe » skin temperature from thermistor

MIBP minimally invasvive blood pressure & core body temperature emkaPACK4G

transmitter

emkaPACK4G

receiver

implant

pressure catheter

temperature probe

carotid

inductive receiver

inductivetransmitter

implantMANAGER

available accessories » ECG calibrator » ECG signal simulator » AA batteries

» batteryless reusable implant » pressure tip measurement » core body temperature measured at thermistor tip » no crosstalk, unique frequency for each animal

» recalibrated by user prior implantation

Lung volume measurement via respiratory inductive plethysmography (RIP):

» thoracic and/or abdominal belt(s), fully adjustable and directly connected to main module » respiration flow derived from lung volume » all standard pulmonary parameters » phase shift computation for bronchoconstriction assessment » easy subject specific absolute calibration

» animal jackets & undershirts » skin electrodes » cuffs, belts

telemetry.emka.fr

Smart solution for noninvasive ECG

» transmitter is fitted with miniature ECG cable and skin electrodes

» transmitter is housed in pocket of custom design jacket

» records calibrated data in iox2, without the need of OpenART™ or acquisition card in computer

» contains its own ambient pressure transducer

In conjonction with Millar, emka TECHNOLOGIES

offers implantable telemetry solutions for animals 200g and over.

Telemeters are recharged by inductive energy transfer, while still in the animal.

Compact, light and powerful

» transmitter has a 22mm diameter and weighs 7g with batteries » 120 hours of continuous recording before replacing batteries » 5m transmission range » excellent noise-free EEG signal » fast acclimation, up to 40 animals per room without required

shielding

rodentPACK is a cost-effective telemetry system to study animals 200g and more, such as rats.

It acquires EEG, EMG, ECG and temperature, as well as acceleration and postural information, suitable for sleep and epilepsy studies, ECG recordings, heart rate variability assessment, etc.

During recording sessions, the miniature transmitter plugs into a connector surgically implanted to the subject’s head.

A single transmitter can be used with any implanted animal.

rodentPACK, telemetry for rodents

easyMATRIX, seamless link from telemetry implants to emkaTECHNOLOGIES software suite

implantable telemetryFull range of parameters

» pressure with solid state sensor (Millar) » biopotentials » SNA » temperature » tissue oxygen

easyMATRIX reads signal from DSI™ implants and only requires connection to existing receivers and to a computer through USB.

An ideal alternative to swivels or implants!

USB connection

easyMATRIX

easyMATRIX

Powerful!

» up to 16 implant receivers and 8 analog inputs connect to a single easyMATRIX

» perfect synchronization of all signals from receivers or analog inputs » handles cases with 1, 2 or 4 receivers used for each subject » up to 4 easyMATRIX can be connected to a single computer

Jacket for noninvasive ECG acquisition

emka TECHNOLOGIES

telemetry solutions from emka TECHNOLOGIES

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CONTACT US!for simple to very demanding projects, please call on us

europe emka TECHNOLOGIES SA59, bd. Général Martial Valin - 75015 Paris - France tel: +33 (0)1 40 60 76 00 - fax: +33 (0)1 40 60 65 55

emka@emka.fr

north america emka TECHNOLOGIES Inc.307 Annandale Road, suite 203 - Falls Church, VA 22042 - USA tel: +1 (703)237-9001 - fax: +1 (703)237-9006

emkatech@emkatech.com

chinaBeijing GYD Labtech Co Ltd Rm 935 Laho Studio, No.15-A1 East Jianguo Road Chaoyang District, Beijing 100024 tel: +86-(0)10-85376382 or +86-(0)13-031151180 or +86-(0)13-01151181fax:+86-(0)10-58208944info@bjgyd.com

emkaPACK4G was designed based on more than 10 years of pioneering experience by emka TECHNOLOGIES in the field of noninvasive telemetry.

There are many strong reasons to use emkaPACK4G large animal telemetry system.

Here are some of the features that make emkaPACK4G the gold standard in noninvasive large animal telemetry:

1- All signals are always available when you need them. In other products, measuring respiration means that you are restricted to only one ECG chest lead.

2- Only emkaPACK4G lets you adjust the hardware sampling frequency, for example, ECG at 500Hz, 1000Hz or even 2000Hz.

3- Respiration belts directly connect to the main transmitter and do not require any adjustments. In other systems you need to add a separate module, which requires manual gain adjustment and runs on a battery which is not user replaceable.

4- Respiration belts are made of inexpensive material very easily cut to the exact required length. Competing product uses predifined belt lengths with limited possible adjustments.

5- emkaPACK4G is the only system that provides 3 different methods to measure blood pressure:

» noninvasive by oscillometric cuff » through vascular access port » from minimally invasive batteryless implant that also

monitors core body temperature.

6- emkaPACK4G minimally invasive pressure implant uses a different frequency for each animal which makes crosstalk impossible in any condition. The competition admits that crosstalk might occur with group house animals.

7- 2-way communication between iox2 and emkaPACK4G

provides multiple possibilities to monitor and control the system:

» transmitters can remotely be turned on or off, a big advantage when an animal needs to be removed or reintroduced in the animal room. Competing product has been known to become unstable in such situation.

» In case of low battery, or if an ECG electrode comes off, or in case of other unwanted events, a specific warning is received by the software which can optionally be forwarded by e-mail to on-call staff members.

8 - emkaPACK4G and iox2 software allow to monitor up to 400 signals simultaneously, from anywhere a LAN connection is available. For example, even if you record 10 signals per subject, you may still monitor a whole 32 subject study with one single set-up.

8 compelling reasons to choose our emkaPACK4G telemetry system!