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Why are Zinc Oxide Sunscreens the best?
cyberdermthe sunscreen company
Thursday, February 23, 2012
DERMATOLOGIC FIRST PRINCIPLES
• Topical agents should act locally and not achieve tissue or blood levels by absorption
• Ideal topical therapy should have zero risk for photo-allergy or photo-contact dermatitis
cyberdermthe sunscreen company
Thursday, February 23, 2012
THE MEDICAL BASIS FOR A SAFE AND EFFECTIVE SUNSCREEN
• Safety
• Exclude all active ingredients that are absorbed, i.e. those with a molecular weight < 500 Daltons
• Efficacy
• Provide broad spectrum UVA and UVB protection with the minimum number of active ingredients
• All ingredients should be photo-stablecyberdermthe sunscreen company
Thursday, February 23, 2012
EXCLUSION FACTOR #1: ABSORPTION
cyberdermthe sunscreen company
0
175
350
525
700
Oxybenzone Octisalate Avobenzone Octinoxate Mexoryl XLMexoryl SX Tinosorb S Tinsorb M
Molecular Weight (Daltons) of Commercially Available Active Ingredients
Min. Molecular Weight of 500 Daltons
Thursday, February 23, 2012
EXCLUSION FACTOR #2: PHOTO-ALLERGIC/ALLERGIC
Photo-Allergic
• Oxybenzone
• PABA
• Avobenzone (Parsol)
• Homosalate
• Octinoxate (Non-Encapsulated)
• Octisalate
cyberdermthe sunscreen company
In descending order of frequencyLevel of risk less than 1%
Allergic• Oxybenzone• Octyl PABA• Octinoxate (Non-Encapsulated)• Avobenzone• Octisalate
Thursday, February 23, 2012
ACTIVE INGREDIENTS THAT MEET THE SAFETY CRITERIA
• Zinc Oxide and Titanium Dioxide
• Tinosorb S and Tinosorb M
• Proprietary to Johnson and Johnson, limited availability,
• Requires adjunctive agents that do not meet the criteria
• Mexoryl SX and Mexoryl XL
• Proprietary to L’Oreal, limited availability,
• Requires adjunctive agents that do not meet the criteria
cyberdermthe sunscreen company
Thursday, February 23, 2012
EFFICACY: BROAD SPECTRUM PROTECTION*
•
Sample Sunscreen with 18% Zinc Oxide, SPF 30 Sample Sunscreen with 3% Avobenzone, 6%
Oxybenzone, 15% Homosalate, 5% Octisalate, 10% Octocrylene, SPF 100
Sample Sunscreen with 2% Avobenzone, 3% Mexoryl SX, 10% Octocrylene, TiO2 5%, SPF 45
cyberdermthe sunscreen company
*Source: Environmental Working Group Skin Deep Database
Thursday, February 23, 2012
CYBERDERM SUNSCREENS:COMING SUMMER 2012
Every Morning Sun Whip SPF 25
• 15 % Zinc Oxide
• 7.5% Encapsulated Octinoxate
cyberdermthe sunscreen company
Simply Zinc Sun Whip SPF 30
• 22% Zinc Oxide
Thursday, February 23, 2012