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explanation, suggested is that contamination mayhave escaped the cordon of precautions during arush period when there was an abnormal demandfor cream. Although the evidence is thus incompletethe report is full of instruction as to the methodstaken to track down the origin of an outbreak of thiskind. The incidence of paratyphoid fever in Londondates from the war period. It was anticipated thatthe return of overseas troops in 1918 and after wouldgive rise to such outbreaks, for the micro-organismsof the Salmonella group may be carried by patientslong after recovery and may be discharged by themintermittently over a long period of time. The
previous outbreak of 1927 in Hertfordshire was
traced to the infection of the milk-supply by twopersons on a farm suffering from the disease in anunrecognised form. Modern sanitation and constantvigilance on the part of sanitary authorities havecombined to keep in check the risks which are everpresent. Happily the condition favourable to thespread of the disease are generally absent whenaccidental infection by a carrier has occurred. An-appendix to the report makes short work of theshameless capital made of this outbreak by some ofthose who wished to see the food regulations revoked,for it shows that the prohibited preservative couldhave had no effect whatever upon the growth ofparatyphoid B ; when the organism was implantedin cream even 4 per cent. of boric acid failed to preventits growth.
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THE LEGAL ASPECT OF STERILISATION.
A RECENT episode at the Old-street police-court maysome day be hailed as the first tentative step towardsthe sterilisation of mental defectives by magisterialdirection. A young man having been charged withdrunkenness and assault, Dr. Williams, a member ofthe medical staff of the London County Council, statedthat he had examined him and was prepared to makean order concerning him under the Mental DeficiencyAct, 1913. The London County Council, he said, wasprepared to place the young man in an institution.Upon request being made on behalf of the relativesthat the accused should be allowed to remain at large,Mr. Clarke Hall, the police-court magistrate, answeredthat, if set at liberty, the young man might propagateother mental defectives. A brother gave the court.an assurance that the accused would not marry.Even so, rejoined the magistrate, he might havechildren. At this point the representative of therelatives is reported to have asked the brother if hewas prepared to have the accused " medicallytreated "—" medical treatment " apparently meaningsterilisation. The brother is reported to haveanswered in the affirmative, Dr. Williams observingthat " it would be rather a new process in thiscountry." After an adjournment the relatives werestill anxious that the defendant should remain atliberty, but his mother was not prepared to agree tothe suggested operation. The magistrate thereforemade an order for his detention in an institution ; " Ido not want," said Mr. Clarke Hall, " to turn out thismental defective of low grade to produce other mentaldefectives." Upon this incident a learned contempor-ary, the Solicitors Journal, makes the comment thatthe suggested operation would be entirely illegal. " Adoctor who performed this operation on a personmentally incapable of giving assent would, at the veryleast, be guilty of a serious assault or unlawfulwounding ; it may also be laid down with someconfidence that, even in the case of a person capableof giving assent and doing so, the operation wouldamount to an assault in a country where the lawforbids consent to that minor form of battery, withtemporary instead of permanent result, known as the" knock-out."
If sterilisation is volunteered on behalf of thedefendant to the magistrate as an alternative todetention and as a basis on which a charge shall bedisposed of, it may seem strange that there should beany element of illegality. Evidently, however, the law
as it stands to-day has its complications. One highauthority on criminal jurisprudence lays down theprinciple that people have a right to consent to theinfiiction upon themselves of bodily harm not amount-ing to maiming. He explains that injuries short ofmaiming are not criminal at common law unless theyare assaults, and an assault is inconsistent with theidea of consent. Maiming (or, to use the old legal term,9 9 mayhem") has a technical meaning. To maim aman, according to Coke upon Littleton, " signifietha corporal hurt whereby he loseth a member byreason whereof he is less able to fight-as by puttingout his eye, beating out his fore-teeth, breaking hisskull, striking off his arm, hand, or finger, cutting offhis leg or foot-or whereby he loseth the use of anyof his said members." Hawkins’ Pleas of the Crownspecially mentions castration as a maiming. Theelement of diminishing the victim’s value as a soldieris interesting if anachronistic. It can even besuggested, as an academic thesis, that the person whoconsents to sterilisation is guilty of the criminal offenceof self-maiming, because, in the language of theSolicitors Journal, " it may be suggested that theSovereign is entitled to rely on his subjects to ensuretheir continuance." There is a statutory offence ofwounding with intent to maim ; under Section 18 ofthe Offences against the Person Act, 1861, it is
punishable with penal servitude for life. A surgicaloperation, if it breaks the continuity of the outerskin, comes within the definition of a wound ; but,so far as Section 18 is concerned, the prosecution mustprove that the wound was inflicted " unlawfully andmaliciously." As for operations upon a personincapable of giving consent, it is clear that a parenthas a right to consent to an operation upon a childwho is too young to exercise a reasonable discretion.And if a patient is in such circumstances as to beincapable of giving consent to an operation-e.g., ifhe is rendered unconscious by a motoring accidentwhich makes it necessary to amputate a limb-it is nota crime to operate without his consent. But thesepropositions seem to presuppose that the operation isreasonably necessary for the saving of life or therepairing of bodily injury. As we indicated last week,certain American States have experimented with thelegalisation of sterilising the insane, and the Ministerof Health has said lately in Parliament that he thinksa proper scientific inquiry into the subject will someday be necessary. At present, however, he seems notto regard the matter as urgent. Our mental defec-tives are, he says, broadly the product of one-tenthof the population, and, out of that one-tenth, onlyone-tenth (or 1 per cent. of the whole) are themselvesdefinitely defectives. The others may be unrecognis-able as defectives, and thus sterilisation can scarcelybe an adequate and final solution of the problem.
THE CICATRISATION OF WOUNDS.
I IN the Presse JJfédicaZe for April 3rd Prof. R. Lerichemakes some suggestive observations on the processeswhich normally lead to the cicatrisation of a wound.Why, when an incision is made into the tissues,processes of repair should immediately be set in actionand the wound should heal has always been unex-plained. The question has a practical as well as aphilosophical bearing on the everyday work of thesurgeon, for if the inner nature of these processes wereknown it might be possible to hasten repair andthereby shorten convalescence after operations. Thesuggestions put forward from time to time, such asWeigert’s theory of the release of restraining tissuetension and the idea of a stimulus by the productsof the digestion of damaged cells, have none of thembeen really satisfactory. It is scarcely credible that asimple modification of tissue tension should be capableof making connective tissue, stabilised for many years,return to an embryonic state. And as for the secondhypothesis, a wound heals all the quicker by firstintention when disintegration is reduced to a minimum ;moreover, the normal changes happen at once,whereas
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proteolytic digestion takes considerable time. Thephenomena seen in aseptic wounds-namely, dilata-tion of vessels, margination of leucocytes, diapedesis,proliferation of fixed connective tissue cells, return to,an embryonic state, and formation of new vessels ygreatly resemble those of inflammation, so that it is6correct to speak of the reaction as traumatic inflamma-tion. The connective tissue takes the principal part’ Iin this. Regeneration may begin but onewly formed connective tissue slows it down andstops it, and eventually cicatrisation takes its place.
Leriche draws attention to the points of similaritybetween these phenomena and those which followevery sympathetic section, whether it concerns thelarge rami, the ganglionic centres, or the peripheralfibres. In each case there is active vaso-dilatation,hyperthermia, an increase in the amplitude of theplilse-wave, and a local leucocytosis. Indeed, everytrauma, contusion, or wound can be regarded as asympathetic injury which must be inevitably followedby an active vaso-dilatory action and an operativewound can be looked on as a series of sections ofthe sympathetic nerves which accompany the blood-vessels. In his view it is this hypersemic reaction whichleads to the changes in the connective tissue designatedtraumatic inflammation. In the hours which followa surgical operation the local temperature is raisedand it remains elevated for several days ; Leriche hasproved that this takes place after a radical cure ofhernia, excision of the elbow-joint, a cold appendec-tomy, suture of a ruptured biceps muscle, and menis-cotomy of the knee-joint. The hyperthermia isregional, but (particularly in the limbs) may spreadfor some distance from the site of operation. Locallyhe has been able to demonstrate a leucocytosis.Macroscopically the changes following surgical traumaare well known to all surgeons who have had occasionto intervene shortly after the first operation, for thewound is congested, there is a diffuse oedema, and afriability of the muscles. All these effects are seenafter an operation upon the sympathetic, whilstMorpurgo has shown experimentally what a greatinfluence the sympathetic innervation has upon thefate of wounds made in a rabbit’s ear. After cervicalsympathectomy he found that the wound will healmore quickly than a control wound on the oppositeneurally intact ear. The hastening of repair aftersympathectomy applies as much to epithelium andbone as to connective tissue. Another factor whichplays an important part in the normal growth oftissues is the hydrogen-ion concentration in the tissuejuice, the optimum pH lying between 7-4 and 7’8.Now sympathectomy and sympathetic section suppressthe acidity of wounds and bring the pH back to themost favourable point.These views on the healing processes, the result of
a good deal of study, deserve careful consideration.Leriche has certainly formulated a hypothesis whichsuffices to explain, in some way at all events, themysterious sequence of events after every surgicaloperation. There seems to be little doubt that sectionof sympathetic rami is one factor in the initiation ofthe healing process. More than this, he suggests thatpost-traumatic or post-operative hypereemia may bethe cause of the favourable results obtained bylaparotomy in tuberculous peritonitis, or the curiousamelioration of symptoms which explorative laparo-tomy so often brings about in cases of inoperablecarcinoma of the stomach. On this hypothesis thegastric mucosa, formerly anaemic, hypopeptic andhypoacid, becomes congested for a few days, furnishinga gastric juice richer in pepsin and hydrochloric acid,and from this arises the subjective impression of cure.
THE FREQUENCY OF UNDETECTED CANCER.THE accuracy of cancer statistics is considerably
impaired by the still appreciable proportion of casesin which cancer is overlooked as a cause of death,and, on the other hand, by the cases wrongly diagnosedas malignant. An interesting contribution to this
problem is made in Norsk Magazin for Laegeviden-skapen for April by Dr. F. G. Gade, who prefacesan account of his own investigations with a summaryof the observations of others. As he points out,Lubarsch’s study of 86,216 necropsies in variousGerman hospitals included 8557 cases of cancer,’among which there were 1131 cases (13 per cent.) inwhich the correct diagnosis had not been made beforedeath. In a still more recent work, dating from 1928,Kranzfeld, of Odessa, found that 15 8 per cent. of thecases found to be malignant post mortem had beenoverlooked. During the 20-year period 1908-27the Norwegian Committee for Cancer Research, Dr.Gade’s offspring, made a special study of the malignantpost-mortem findings of the pathological laboratoryof Ullevaal, Oslo’s communal hospital. Among the1618 necropsies on malignant cases (850 men,768 women), which included 211 cases of sarcoma,there were 183 (11-4 per cent.) in which the malignantdisease had hitherto been overlooked. This percentageof overlooked cases compares favourably with theGerman and Russian figures. But in 1915 it was ashigh as 29, and in 1926 as low as five, the average forthe last half of the 20-year period being 8-4 per cent.A remarkable inequality in the sex distribution ofthese undetected cases was observed, as great a
proportion as 67-8 per cent. being males, although thecomparative incidence of malignant disease in malesand females in Norway is as 52-5 to 47-5. Theaverage age of the persons whose malignant diseasehad been overlooked was somewhat higher than thatof the persons whose malignant disease had beendetected before death. Curiously enough, there wasonly one case on record in which a diagnosis of cancer(of the rectum) was proved post mortem to beincorrect, but Dr. Gade assumes that several similarcases must have escaped record. The most commondiagnosis in the cases of overlooked cancer was
" debilitas senilis." Another category which mustinclude many cases of cancer comes under the heading" deaths from unknown causes." In the north ofNorway (Finnmark) 16-7 per cent. of all the deaths in1925 were placed in this category. Assuming that theincidence of cancer is quite as high in this group asamong all the deaths from known causes, Dr. Gadecalculates that if the deaths from unknown causes beassumed to represent 2-7 per cent. of all the deathsin 1925, and an addition be made of 12 per cent. ofthe notified cases of cancer, to make good the propor-tion of overlooked cases, then the return of cancerdeaths in this year ought to be increased by 489,from 3259 to 3748-i.e., a supplement of 14-7 percent. Calculations such as these show that, high asare the figures indicating the mortality from cancerduring recent years, it is still seriously underestimated.
THE CASE FOR OPEN-AIR SCHOOLS.
THE recent decision of the Hornsey Town Councilto defer for two years a well thought-out scheme forestablishing an open-air school has led to the publicdiscussion of a matter which is of considerableimportance to the educational and public healthauthorities as well as to the pockets of the ratepayer.Unable to reach unanimity last October the Councilpostponed its decision for its newly appointed medicalofficer of health, Dr. R. P. Garrow, to report on thescheme. Dr. Garrow was able to draw on his specialexperience in Chesterfield where much advancedwork has been done in modern school construc-tion along open-air lines, and his adverse report onthe scheme as drawn up was based on the followingconsiderations :-
(1) The rapid evolution of the open-air principle in generalschools.
(2) The steadily diminishing incidence of the chiefcrippling diseases.
(3) The fact that bad orthopaedic cases can only be dealtwith in residential schools and hospitals.
(4) The undesirability of segregating cripples.(5) The desirability of centring effort in the child’s
home.